CN102319258B - 5 percent glucose substitution liquid and preparation method thereof - Google Patents
5 percent glucose substitution liquid and preparation method thereof Download PDFInfo
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- CN102319258B CN102319258B CN2011102212754A CN201110221275A CN102319258B CN 102319258 B CN102319258 B CN 102319258B CN 2011102212754 A CN2011102212754 A CN 2011102212754A CN 201110221275 A CN201110221275 A CN 201110221275A CN 102319258 B CN102319258 B CN 102319258B
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- Prior art keywords
- glucose
- injection
- water
- displacement liquid
- milligrams
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 35
- 239000008103 glucose Substances 0.000 title claims abstract description 31
- 239000007788 liquid Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 238000006467 substitution reaction Methods 0.000 title abstract 5
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 title abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000008215 water for injection Substances 0.000 claims abstract description 31
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 22
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 14
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims abstract description 11
- 229940040526 anhydrous sodium acetate Drugs 0.000 claims abstract description 11
- XKPKPGCRSHFTKM-UHFFFAOYSA-L magnesium;diacetate;tetrahydrate Chemical compound O.O.O.O.[Mg+2].CC([O-])=O.CC([O-])=O XKPKPGCRSHFTKM-UHFFFAOYSA-L 0.000 claims abstract description 11
- 235000011056 potassium acetate Nutrition 0.000 claims abstract description 11
- 239000011780 sodium chloride Substances 0.000 claims abstract description 11
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims abstract description 11
- 235000010262 sodium metabisulphite Nutrition 0.000 claims abstract description 11
- 230000001954 sterilising effect Effects 0.000 claims abstract description 11
- 230000008569 process Effects 0.000 claims abstract description 6
- 238000006073 displacement reaction Methods 0.000 claims description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 14
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 5
- 238000007796 conventional method Methods 0.000 claims description 5
- 230000001186 cumulative effect Effects 0.000 claims description 5
- 238000005262 decarbonization Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 229940095491 glucose 5000 mg Drugs 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 238000007689 inspection Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 229960004109 potassium acetate Drugs 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 4
- 229940093181 glucose injection Drugs 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 230000035790 physiological processes and functions Effects 0.000 abstract description 2
- 230000009467 reduction Effects 0.000 abstract description 2
- 230000008859 change Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 238000007865 diluting Methods 0.000 abstract 1
- 229940097364 magnesium acetate tetrahydrate Drugs 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 229940001584 sodium metabisulfite Drugs 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 description 4
- 229940090044 injection Drugs 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of medical medicines, and particularly relates to 5 percent glucose substitution liquid and a preparation method thereof. By the substitution liquid, the problem that medicines are needed to be prepared specially due to reduction of a medicinal effect or discomfort in patients caused by some medicines and the conventional glucose injection compounding agent is solved. The preparation method for the 5 percent glucose substitution liquid comprises the following steps of: adding the following components: 5,000 milligrams of glucose, 573 milligrams of sodium chloride, 346 milligrams of anhydrous sodium acetate, 49 milligrams of potassium acetate, 32.2 milligrams of magnesium acetate tetrahydrate and 30 milligrams of sodium metabisulfite into 100 milliliters of water for injection, concentrating, diluting, filling and sterilizing. The 5 percent glucose substitution liquid can regulate the physiological functions of human bodies and change the fussy process of preparing reagents by nurses, and is convenient to use, high in safety and stable in curative effect.
Description
Technical field
The invention belongs to the medical drugs technical field, be specifically related to a kind of 5% glucose displacement liquid and preparation method thereof.
Background technology
When hospital infuses for the patient; The ingredients problem that often has multiple medicine; Some medicament be can not with the glucose injection of routine ingredients together; The therapeutic effect that uses glucose injection can influence medicine in other words perhaps causes subject discomfort, therefore just needs the nurse to make up a prescription separately, has reduced nurse's labor efficiency.
Summary of the invention
The present invention is primarily aimed at some medicine and has the drug effect reduction or cause that patient body is uncomfortable with conventional glucose injection ingredients; The problem that need make up a prescription specially, and provide a kind of and need not to make up a prescription specially, easy to use, good effect and 5% safe glucose displacement liquid.
Another object of the present invention provides the method for preparing of this displacement liquid.
The present invention solves the problems of the technologies described above the technical scheme that adopts to be:
A kind of 5% glucose replacement liquid prescription is in 100mL water for injection, to add following component: glucose 5000mg, sodium chloride 573mg, anhydrous sodium acetate 346mg, potassium acetate 49mg, Magnesium acetate (Mg(OAc)2) tetrahydrate 32.2mg, sodium pyrosulfite 30mg.
The method for preparing of the present invention's 5% glucose displacement liquid may further comprise the steps:
1) dense joining: get volume and be prescription water for injection cumulative volume 30～35%; Temperature is that 70～75 ℃ water for injection is in dense preparing tank; Add the glucose and the sodium chloride of formula ratio, stirring and dissolving is complete, adds active carbon again; Be incubated absorption 10～13 minutes down at 70～75 ℃, send into dilute preparing tank behind the decarbonization filtering;
2) rare joining: the anhydrous sodium acetate, potassium acetate, Magnesium acetate (Mg(OAc)2) tetrahydrate and the sodium pyrosulfite that in dilute preparing tank, add formula ratio successively; Stirred 15～20 minutes; Add again the injection water quantitatively arrive water for injection overall 99%; Using hydrochloric acid solution to regulate pH value then is 4.8～5.8, quantitatively arrives formula ratio with water for injection once more, sends into bulking system behind the mix homogeneously;
3) fill sterilization: after the conventional method bottling, sterilization is 15 minutes under 121 ℃ of conditions, after the lamp inspection packing, processes 5% glucose displacement liquid again.
Wherein the preferred active carbon addition of the present invention be in the dense preparing tank water for injection weight 0.1%.
The concentration of preferred hydrochloric acid solution is 0.1mol/L.
For showing the performance of the present invention's 5% glucose displacement liquid, done respective detection, specifically detect data and see table 1,
Table 1 5% glucose displacement liquid liquid test item and result
Testing result shows that the 5% glucose displacement liquid that the present invention produces meets the requirements fully, and its prescription can effectively be regulated human physiological functions, changes the loaded down with trivial details, easy to use, safe of nurse's ingredients, stable curative effect.
The specific embodiment
Embodiment 1
The prescription of present embodiment 5% glucose displacement liquid is in 100mL water for injection, to add following component: glucose 5000mg, sodium chloride 573mg, anhydrous sodium acetate 346mg, potassium acetate 49mg, Magnesium acetate (Mg(OAc)2) tetrahydrate 32.2mg and sodium pyrosulfite 30mg.
The concrete method for preparing of present embodiment may further comprise the steps:
1) dense joining: get volume and be prescription water for injection cumulative volume 30%; Temperature is that 70 ℃ water for injection is in dense preparing tank; Add the glucose and the sodium chloride of formula ratio, stirring and dissolving is complete, adds the active carbon of water for injection weight 0.1% in the dense preparing tank again; Be incubated absorption 10 minutes down at 70 ℃, send into dilute preparing tank behind the decarbonization filtering;
2) rare joining: the anhydrous sodium acetate, potassium acetate, Magnesium acetate (Mg(OAc)2) tetrahydrate and the sodium pyrosulfite that in dilute preparing tank, add formula ratio successively; Stirred 15 minutes; Add again the injection water quantitatively arrive water for injection overall 99%; Using concentration to regulate pH value as the hydrochloric acid solution of 0.1mol/L then is 4.8, quantitatively arrives formula ratio with water for injection once more, sends into bulking system behind the mix homogeneously;
3) fill sterilization: after the conventional method bottling, sterilization is 15 minutes under 121 ℃ of conditions, after the lamp inspection packing, processes 5% glucose displacement liquid again.
Embodiment 2
The prescription of present embodiment 5% glucose displacement liquid is in 100mL water for injection, to add following component: glucose 5000mg, sodium chloride 573mg, anhydrous sodium acetate 346mg, potassium acetate 49mg, Magnesium acetate (Mg(OAc)2) tetrahydrate 32.2mg and sodium pyrosulfite 30mg.
The concrete method for preparing of present embodiment may further comprise the steps:
1) dense joining: get volume and be prescription water for injection cumulative volume 32%; Temperature is that 73 ℃ water for injection is in dense preparing tank; Add the glucose and the sodium chloride of formula ratio, stirring and dissolving is complete, adds the active carbon of water for injection weight 0.1% in the dense preparing tank again; Be incubated absorption 12 minutes down at 73 ℃, send into dilute preparing tank behind the decarbonization filtering;
2) rare joining: the anhydrous sodium acetate, potassium acetate, Magnesium acetate (Mg(OAc)2) tetrahydrate and the sodium pyrosulfite that in dilute preparing tank, add formula ratio successively; Stirred 18 minutes; Add again the injection water quantitatively arrive water for injection overall 99%; Using concentration to regulate pH value as the hydrochloric acid solution of 0.1mol/L then is 5.2, quantitatively arrives formula ratio with water for injection once more, sends into bulking system behind the mix homogeneously;
3) fill sterilization: after the conventional method bottling, sterilization is 15 minutes under 121 ℃ of conditions, after the lamp inspection packing, processes 5% glucose displacement liquid again.
Embodiment 3
The prescription of present embodiment 5% glucose displacement liquid is in 100mL water for injection, to add following component: glucose 5000mg, sodium chloride 573mg, anhydrous sodium acetate 346mg, potassium acetate 49mg, Magnesium acetate (Mg(OAc)2) tetrahydrate 32.2mg and sodium pyrosulfite 30mg.
The concrete method for preparing of present embodiment may further comprise the steps:
1) dense joining: get volume and be prescription water for injection cumulative volume 35%; Temperature is that 75 ℃ water for injection is in dense preparing tank; Add the glucose and the sodium chloride of formula ratio, stirring and dissolving is complete, adds the active carbon of water for injection weight 0.1% in the dense preparing tank again; Be incubated absorption 13 minutes down at 75 ℃, send into dilute preparing tank behind the decarbonization filtering;
2) rare joining: the anhydrous sodium acetate, potassium acetate, Magnesium acetate (Mg(OAc)2) tetrahydrate and the sodium pyrosulfite that in dilute preparing tank, add formula ratio successively; Stirred 20 minutes; Add again the injection water quantitatively arrive water for injection overall 99%; Using concentration to regulate pH value as the hydrochloric acid solution of 0.1mol/L then is 5.8, quantitatively arrives formula ratio with water for injection once more, sends into bulking system behind the mix homogeneously;
3) fill sterilization: after the conventional method bottling, sterilization is 15 minutes under 121 ℃ of conditions, after the lamp inspection packing, processes 5% glucose displacement liquid again.
Claims (4)
1. a glucose displacement liquid is characterized in that the prescription of said 5% glucose displacement liquid is the following component of adding in 100mL water for injection: glucose 5000mg, sodium chloride 573mg, anhydrous sodium acetate 346mg, potassium acetate 49mg, Magnesium acetate (Mg(OAc)2) tetrahydrate 32.2mg and sodium pyrosulfite 30mg.
2. the method for preparing of the described 5% glucose displacement liquid of claim 1 is characterized in that may further comprise the steps:
1) dense joining: get volume and be prescription water for injection cumulative volume 30～35%; Temperature is that 70～75 ℃ water for injection is in dense preparing tank; Add the glucose and the sodium chloride of formula ratio, stirring and dissolving is complete, adds active carbon again; Be incubated absorption 10～13 minutes down at 70～75 ℃, send into dilute preparing tank behind the decarbonization filtering;
2) rare joining: the anhydrous sodium acetate, potassium acetate, Magnesium acetate (Mg(OAc)2) tetrahydrate and the sodium pyrosulfite that in dilute preparing tank, add formula ratio successively; Stirred 15～20 minutes; Add again the injection water quantitatively arrive water for injection overall 99%; Using hydrochloric acid solution to regulate pH value then is 4.8～5.8, quantitatively arrives formula ratio with water for injection once more, sends into bulking system behind the mix homogeneously;
3) fill sterilization: after the conventional method bottling, sterilization is 15 minutes under 121 ℃ of conditions, after the lamp inspection packing, processes 5% glucose displacement liquid again.
3. the method for preparing of 5% glucose displacement liquid according to claim 2, it is characterized in that described active carbon addition be in the dense preparing tank water for injection weight 0.1%.
4. the method for preparing of 5% glucose displacement liquid according to claim 2, the concentration that it is characterized in that described hydrochloric acid solution is 0.1mol/L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102212754A CN102319258B (en) | 2011-08-04 | 2011-08-04 | 5 percent glucose substitution liquid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102212754A CN102319258B (en) | 2011-08-04 | 2011-08-04 | 5 percent glucose substitution liquid and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102319258A CN102319258A (en) | 2012-01-18 |
| CN102319258B true CN102319258B (en) | 2012-10-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011102212754A Expired - Fee Related CN102319258B (en) | 2011-08-04 | 2011-08-04 | 5 percent glucose substitution liquid and preparation method thereof |
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| CN (1) | CN102319258B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103372022A (en) * | 2012-04-28 | 2013-10-30 | 徐连秀 | Glucose health-care oral solution and preparation method |
| CN105125487A (en) * | 2015-10-23 | 2015-12-09 | 广西裕源药业有限公司 | Production method for preventing liquid medicine turbidity of plastic bottled dextrose injection |
| CN109731008A (en) * | 2018-12-20 | 2019-05-10 | 江西润泽药业有限公司 | Children's electrolyte feeds injection and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209751A (en) * | 1996-01-25 | 1999-03-03 | 舍林股份公司 | Improved concentrated injection and infusion solutions for intravenous administration |
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2011
- 2011-08-04 CN CN2011102212754A patent/CN102319258B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209751A (en) * | 1996-01-25 | 1999-03-03 | 舍林股份公司 | Improved concentrated injection and infusion solutions for intravenous administration |
Non-Patent Citations (2)
| Title |
|---|
| 李瑞林.肠外营养支持及肠外营养配制与使用中的注意事项.《药学实践杂志》.2006,第24卷(第4期),第250-251页. |
| 肠外营养支持及肠外营养配制与使用中的注意事项;李瑞林;《药学实践杂志》;20061231;第24卷(第4期);第250-251页 * |
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| CN102319258A (en) | 2012-01-18 |
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Granted publication date: 20121031 Termination date: 20180804 |