CN102284002A - Traditional Chinese medicine for treating lupus erythematosus - Google Patents
Traditional Chinese medicine for treating lupus erythematosus Download PDFInfo
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- CN102284002A CN102284002A CN2011102346161A CN201110234616A CN102284002A CN 102284002 A CN102284002 A CN 102284002A CN 2011102346161 A CN2011102346161 A CN 2011102346161A CN 201110234616 A CN201110234616 A CN 201110234616A CN 102284002 A CN102284002 A CN 102284002A
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Abstract
The invention provides a traditional Chinese medicine for treating lupus erythematosus, which comprises the following components in parts by weight: 25-35 parts of radix astragali, 12-18 parts of rhizoma polygonati, 25-35 parts of spatholobus stem, 25-35 parts of radix gentianae macrophyllae, 4-8 parts of black-tail snake, 25-35 parts of radix salviae miltiorrhizae, 8-16 parts of Plumula Nelumbinis, 6-12 parts of polygonatum, 4-8 parts of white ginseng, 12-18 parts of radix paeoniae alba, 12-18 parts of angelica, 25-35 parts of glossy privet fruit, 25-35 parts of radix rehmanniae preparata and 4-8 parts of coptis. The traditional Chinese medicine for treating lupus erythematosus has the advantages of favorable effect and low recurrence rate, can treat both the symptoms and root causes, and effectively relieves the patients of pains.
Description
Technical field
The present invention relates to a kind of Chinese medicine, more particularly, relate to a kind of Chinese medicine for the treatment of lupus erythematosus.
Background technology
Lupus erythematosus is a kind of many organs of health multisystem that involve, complicated clinical manifestation, course of disease delay autoimmune disease repeatedly.
The pathogenesis of lupus erythematosus is not illustrated as yet fully, studies show that in a large number primary disease is a kind of autoimmune disease, can involve health multisystem, many organs, can find multiple autoantibody in patient's blood and organ.Some have the lupus erythematosus patient of inherited genetic factors, under some external world or the effect of inside of human body factor, inspired an immunne response as viral infection, sunlight exposure, psychic trauma, medicine, gestation etc., thereby produce multiple antibody and the immune complex of resisting autologous tissue, cause the human body self tissue, as organ and tissues such as skin, blood vessel, the heart, liver, kidney, brains, malpractice is outbreak repeatedly easily, and each recurrence all might increase the weight of the state of an illness.The western medical treatment lupus erythematosus adopts hormone more, can't stablize control.Therapeutic effect is not obvious, and it is slow to take effect.Owing to can not get effective alleviation, lupus erythematosus patient stands skin lesion for a long time, arthropathy, and heart, respiratory system also can suffer damage.Clinical characteristics still can be involved vitals such as the heart, kidney simultaneously except that skin lesion is arranged, often with General Symptomies such as heating, joint aches.
Summary of the invention
Problem in view of above-mentioned prior art exists the purpose of this invention is to provide a kind of Chinese medicine for the treatment of lupus erythematosus, and it is at the comprehensive cause of disease of lupus erythematosus, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, and it is effective, relapse rate is low, treating both the principal and secondary aspects of a disease, has effectively removed patient's slight illness.
In order to address the above problem, the present invention by the following technical solutions: a kind of Chinese medicine for the treatment of lupus erythematosus, in weight portion, comprise following component: Radix Astragali 25-35, Rhizoma Polygonati 12-18, Caulis Spatholobi 25-35, Radix Gentianae Macrophyllae 25-35, Zaocys 4-8, Radix Salviae Miltiorrhizae 25-35, Plumula Nelumbinis 8-16, Rhizoma Polygonati Odorati 6-12, Radix Ginseng 4-8, Radix Paeoniae Alba 12-18, Radix Angelicae Sinensis 12-18, Fructus Ligustri Lucidi 25-35, Radix Rehmanniae Preparata 25-35, Rhizoma Coptidis 4-8.
The Analysis on Mechanism of Chinese medicine of the present invention:
The Radix Astragali: sweet, tepor.Return lung, spleen, liver, kidney channel.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer." the herbal speech that converges ":,,, control impairment caused by overstrain, longue meat so energy complement sun fills space between skin and muscles so specially reach table in edema caused by disorder of QI because of its flavor is light.The deficiency of vital energy and difficult antiperspirant person can send out, table is dredged and hyperhidrosis person can end.
Rhizoma Polygonati: sweet, flat.Return lung, spleen, kidney channel.The nourishing kidney lung moistening, invigorating the spleen and replenishing QI." herbal classic is met former ": Rhizoma Polygonati, the alleviating distention in middle-JIAO QI invigorating makes five to hide mediation, and muscle sufficiency, bone marrow are hard by force, all are the merits of nourishing YIN.
Caulis Spatholobi: bitter, sweet, temperature.Return liver, kidney channel.Enrich blood, invigorate blood circulation, collateral dredging.Join Herba Leonuri, blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving; Join Rhizoma Atractylodis, regulating QI to expel dampness, ward off dirty go turbid; Join the Cortex Eucommiae, invigorating the kidney and strengthening the bones, inducing menstruation to relieve menalgia; Join Radix Angelicae Sinensis, enrich blood and invigorate blood circulation." decoction pieces is newly joined ": blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, wind arthralgia due to stagnation of blood disease.
Radix Gentianae Macrophyllae: bitter, hot, be slightly cold.Return stomach, liver, gallbladder meridian.Expelling wind and removing dampness and blood Shujin, clearing away heat and promoting diuresis.The dispelling the wind and dampness pathogens arthralgia pain, the muscles and bones contracture, jaundice is had blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria." book on Chinese herbal medicine is just ": separate the pestilence pyretic toxicity, vaporization heat of bone, hectic fever excessive thirst and married woman's fetal heat in pregnancy, children's's infantile malnutrition with fever is thin and weak.
Zaocys: sweet, flat.Return Liver Channel.Dispel the wind collateral dredging, relieving convulsion.Be used for rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
Radix Salviae Miltiorrhizae: hardship, tepor.Go into the heart, Liver Channel.Blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus, pain relieving." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaking water, and cold and heat gather; Po Disorder removes abdominal mass, ends stuffy sensation with restlessness, QI invigorating.
Plumula Nelumbinis: hardship, cold.Go into the heart, lung, kidney three warps.Clear away heart-fire, reduce phlegm and internal heat, hemostasis, arresting seminal emission.Control vexedly, thirsty, spit blood seminal emission, conjunctival congestion and swelling pain." this leather is new again ": clearing away heart-fire, the suppressing the hyperactive liver fire, lung-fire falls in the purgation of spleen excess fire.The relieving restlessness of relieving summer heat is given birth to rule and is quenched the thirst, and controls the order redness.
Rhizoma Polygonati Odorati: sweet in the mouth is flat.Go into lung, stomach warp.Yin nourishing is moisturized, and relieving restlessness is quenched the thirst, invigorating the spleen and replenishing QI.Control the cloudy wound of calentura, the cough excessive thirst, deficient fever, rapid digestion of food are easily hungry, frequent micturition." herbal classic ": main apoplexy sudden high fever, can not shake, fall muscle knot meat, various symptoms and signs of deficiency.Clothes go to the dark complexion open country for a long time, and good color is moist.
Radix Ginseng: sweet little hardship, temperature.Go into spleen, lung meridian.Strongly invigorating primordial QI promotes the production of body fluid admittedly take off, and calms the nerves." pearl sac ": " nourish blood, mend gastric qi, eliminating heart-fire."
The Radix Paeoniae Alba: picric acid, cold.Go into liver, spleen channel.Nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia." herbal classic ": " main pathogen stomachache is removed arthralgia due to stagnation of blood, and is broken hard long-pending, controls cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.”
Radix Angelicae Sinensis: Gan Xin, temperature.Go into the heart, liver, spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving is moisturized laxation." Japan hanako materia medica ": control a wind cutting, all blood are mended all labor, and broken stagnant blood is supported fresh blood and main Disorder addiction.
Fructus Ligustri Lucidi: sweet, bitter, cold.Return liver, kidney channel.Nourishing the liver and kidney, black hair makes eye bright." book on Chinese herbal medicine is new again ": replenishing YIN to strengthen the kidney, QI invigorating soothing liver-QI.Control lumbago and skelalgia, stimulate the menstrual flow and blood.
Radix Rehmanniae Preparata: sweet in the mouth; Warm in nature.Return liver; Kidney channel.It is moist to enrich blood; The benefit essence is filled out marrow." book on Chinese herbal medicine is just ": Radix Rehmanniae Preparata is flat, and abnormal smells from the patient is pure quiet, thus can tonifying five ZANG-organs Kidney-Yin, and in many blood dirty for will, must non-taste why the survivor be arranged, gas and Tremella samguinea Peng through medicine that and madam.
Rhizoma Coptidis: hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication." not Lu ": main the five internal organs be cold and hot, let out down for a long time and debate pus and blood, only quench one's thirst, and are frightened, remove the water conservancy bone, transfer the thick intestinal of stomach, beneficial gallbladder, treatment aphtha.
According to the Chinese medicine of treatment lupus erythematosus of the present invention, in the principle of adjusting, balance internal organs, follow and ward off the dirty principle turbid, heat-clearing and toxic substances removing of going within its integrated use traditional Chinese medical science, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, mutual reinforcement between is for using.Plumula Nelumbinis, Rhizoma Coptidis, Radix Gentianae Macrophyllae in the side, merit is at heat-clearing and toxic substances removing, cool the blood dissipate blood stasis; Assistant is with the yin nourishing of enriching blood of Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Polygonati Odorati, Caulis Spatholobi, broken stagnant blood, stasis of blood person's pathogenic factor also, heresy goes to see Zhengan County, the stasis of blood then newborn ruton of dispelling; Radix Ginseng, Radix Salviae Miltiorrhizae, Rhizoma Polygonati blood circulation promoting and blood stasis dispelling make the power multiplication of heat-clearing and toxic substances removing, cool the blood dissipate blood stasis; Radix Astragali strengthening the body resistance, the immunoregulation effect that tool is two-way; Zaocys, Radix Gentianae Macrophyllae dispel the wind, and collateral dredging is from this radical cure systemic lupus erythematosus (sle).All medicine compatibilities dispel the wind, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors, and effect is remarkable, doublely takes stopgap measures this.
Chinese medicine preparation of the present invention can adopt dosage forms such as tablet, granule, pill, capsule, solution, oral liquid, buccal tablet, granule, electuary, powder, suspensoid, powder, preferably, can adopt solution, tablet, granule and capsule.
Result of use
The treatment group: select experimenter's 30 examples, 15 routine male wherein, 15 routine women, age 30-40 year, take Chinese medicine of the present invention twice sooner or later, continue 1 month.
Matched group: select experimenter's 30 examples, 15 routine male wherein, 15 routine women, age 30-40 year, treat with glucocorticoid, continue 1 month.
Judgment criteria:
1. cure: low grade fever disappears, and skin lesion is alleviated, disappeared; Arthralgia obviously alleviates, and focus alleviates, heart, renal system remission;
2. effective: low grade fever, skin lesion goes down, and arthralgia alleviates;
3. invalid: no change, symptom does not have mitigation.
Continued treatment is after 2 courses of treatment, and the result shows, healing number 16 people in the treatment group; Effective number 11 people; Invalid number 3 people, overall effective percentage reaches 90%.And healing number 12 people in the matched group; Effective number 14 people; Invalid number 4 people; Overall effective percentage is 86.7%, but there is the risk that causes side effect such as steroid diabetes and Cushing's syndrome in matched group.
The specific embodiment
In order to understand the present invention better, the present invention is described below by embodiment.
Embodiment 1
A kind of Chinese medicine for the treatment of lupus erythematosus in weight portion, comprises following component: the Radix Astragali 25, Rhizoma Polygonati 12, Caulis Spatholobi 25, Radix Gentianae Macrophyllae 25, Zaocys 4, Radix Salviae Miltiorrhizae 25, Plumula Nelumbinis 8, Rhizoma Polygonati Odorati 6, Radix Ginseng 4, the Radix Paeoniae Alba 12, Radix Angelicae Sinensis 12, Fructus Ligustri Lucidi 25, Radix Rehmanniae Preparata 25, Rhizoma Coptidis 4.
Its preparation method is:
In weight portion, get the Radix Astragali 25, Rhizoma Polygonati 12, Caulis Spatholobi 25, Radix Gentianae Macrophyllae 25, Zaocys 4, Radix Salviae Miltiorrhizae 25, Plumula Nelumbinis 8, Rhizoma Polygonati Odorati 6, Radix Ginseng 4, the Radix Paeoniae Alba 12, Radix Angelicae Sinensis 12, Fructus Ligustri Lucidi 25, Radix Rehmanniae Preparata 25, Rhizoma Coptidis 4; Above-mentioned Chinese medicine is cleaned, and decontamination is put into container and is added water and do not have medical material to soak, and after 30 minutes, big fire decocts to boiling, and slow fire was endured 1 hour slowly then; Medicine juice is leached, bag distribution packaging, one bag of 200ml sooner or later respectively obeys one bag, and the dual-purpose medicinal liquid cleans affected part, and 1 month is a course of treatment.
Embodiment 2
A kind of Chinese medicine for the treatment of lupus erythematosus in weight portion, comprises following component: the Radix Astragali 35, Rhizoma Polygonati 18, Caulis Spatholobi 35, Radix Gentianae Macrophyllae 35, Zaocys 8, Radix Salviae Miltiorrhizae 35, Plumula Nelumbinis 16, Rhizoma Polygonati Odorati 12, Radix Ginseng 8, the Radix Paeoniae Alba 18, Radix Angelicae Sinensis 18, Fructus Ligustri Lucidi 35, Radix Rehmanniae Preparata 35, Rhizoma Coptidis 8.
Its preparation method is:
In weight portion, get the Radix Astragali 35, Rhizoma Polygonati 18, Caulis Spatholobi 35, Radix Gentianae Macrophyllae 35, Zaocys 8, Radix Salviae Miltiorrhizae 35, the sub-heart 16, Rhizoma Polygonati Odorati 12, Radix Ginseng 8, the Radix Paeoniae Alba 18, Radix Angelicae Sinensis 18, Fructus Ligustri Lucidi 35, Radix Rehmanniae Preparata 35, Rhizoma Coptidis 8;
Cleaning, drying mix above-mentioned medical material, and per kilogram adds about 10L water, and 0.5-1 at a simmer hour, big fire was fried in shallow oil 1-2 hour; Get decocting liquid and cross 150 mesh sieves, the back is concentrated into the clear paste of relative density 1.10-1.20 with concentrator, gets 2/3 clear paste 120 ℃ of following spray dryinges, the clear paste powder, powder is mixed granulation with residue 1/3 clear paste; The packing of granule racking machine promptly gets granule.
Embodiment 3
A kind of Chinese medicine for the treatment of lupus erythematosus in weight portion, comprises following component: the Radix Astragali 30, Rhizoma Polygonati 15, Caulis Spatholobi 30, Radix Gentianae Macrophyllae 30, Zaocys 6, Radix Salviae Miltiorrhizae 30, Plumula Nelumbinis 12, Rhizoma Polygonati Odorati 9, Radix Ginseng 6, the Radix Paeoniae Alba 15, Radix Angelicae Sinensis 15, Fructus Ligustri Lucidi 30, Radix Rehmanniae Preparata 30, Rhizoma Coptidis 6.
Its preparation method is:
In weight portion, get the Radix Astragali 30, Rhizoma Polygonati 15, Caulis Spatholobi 30, Radix Gentianae Macrophyllae 30, Zaocys 6, Radix Salviae Miltiorrhizae 30, Plumula Nelumbinis 12, Rhizoma Polygonati Odorati 9, Radix Ginseng 6, the Radix Paeoniae Alba 15, Radix Angelicae Sinensis 15, Fructus Ligustri Lucidi 30, Radix Rehmanniae Preparata 30, Rhizoma Coptidis 6; Cleaning, drying mix above-mentioned medical material, and per kilogram adds about 10L water, and 0.5-1 at a simmer hour, big fire was fried in shallow oil 1-2 hour; Get decocting liquid and cross 150 mesh sieves, the back is concentrated into the clear paste of relative density 1.10-1.20 with concentrator, gets 2/3 clear paste 120 ℃ of following spray dryinges, the clear paste powder, powder is mixed granulation with residue 1/3 clear paste;
Add suitable adjuvant magnesium stearate, the tablet machine tabletting, coating promptly gets tablet.
Embodiment 4
A kind of Chinese medicine for the treatment of lupus erythematosus in weight portion, comprises following component: the Radix Astragali 30, Rhizoma Polygonati 15, Caulis Spatholobi 30, Radix Gentianae Macrophyllae 30, Zaocys 6, Radix Salviae Miltiorrhizae 30, Plumula Nelumbinis 12, Rhizoma Polygonati Odorati 9, Radix Ginseng 6, the Radix Paeoniae Alba 15, Radix Angelicae Sinensis 15, Fructus Ligustri Lucidi 30, Radix Rehmanniae Preparata 30, Rhizoma Coptidis 6.
Its preparation method is:
In weight portion, get the Radix Astragali 30, Rhizoma Polygonati 15, Caulis Spatholobi 30, Radix Gentianae Macrophyllae 30, Zaocys 6, Radix Salviae Miltiorrhizae 30, Plumula Nelumbinis 12, Rhizoma Polygonati Odorati 9, Radix Ginseng 6, the Radix Paeoniae Alba 15, Radix Angelicae Sinensis 15, Fructus Ligustri Lucidi 30, Radix Rehmanniae Preparata 30, Rhizoma Coptidis 6; Cleaning, drying mix above-mentioned medical material, and per kilogram adds about 10L water, and 0.5-1 at a simmer hour, big fire was fried in shallow oil 1-2 hour; Get decocting liquid and cross 150 mesh sieves, the back is concentrated into the clear paste of relative density 1.10-1.20 with concentrator, gets 2/3 clear paste 120 ℃ of following spray dryinges, the clear paste powder, powder is mixed granulation with residue 1/3 clear paste; Granule is made the 0.4g/ capsules with the capsule filler.
Claims (4)
1. a Chinese medicine for the treatment of lupus erythematosus is characterized in that, in weight portion, comprise following component: Radix Astragali 25-35, Rhizoma Polygonati 12-18, Caulis Spatholobi 25-35, Radix Gentianae Macrophyllae 25-35, Zaocys 4-8, Radix Salviae Miltiorrhizae 25-35, Plumula Nelumbinis 8-16, Rhizoma Polygonati Odorati 6-12, Radix Ginseng 4-8, Radix Paeoniae Alba 12-18, Radix Angelicae Sinensis 12-18, Fructus Ligustri Lucidi 25-35, Radix Rehmanniae Preparata 25-35, Rhizoma Coptidis 4-8.
2. Chinese medicine according to claim 1 is characterized in that, in weight portion, preferably comprises following component: the Radix Astragali 30, Rhizoma Polygonati 15, Caulis Spatholobi 30, Radix Gentianae Macrophyllae 30, Zaocys 6, Radix Salviae Miltiorrhizae 30, Plumula Nelumbinis 12, Rhizoma Polygonati Odorati 9, Radix Ginseng 6, the Radix Paeoniae Alba 15, Radix Angelicae Sinensis 15, Fructus Ligustri Lucidi 30, Radix Rehmanniae Preparata 30, Rhizoma Coptidis 6.
3. Chinese medicine according to claim 1 and 2 is characterized in that, described Chinese medicine adopts tablet, granule, pill, capsule, solution, oral liquid, buccal tablet, granule, electuary, powder, suspensoid, powder.
4. Chinese medicine according to claim 3 is characterized in that, described Chinese medicine adopts solution, tablet, granule and capsule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102346161A CN102284002A (en) | 2011-08-16 | 2011-08-16 | Traditional Chinese medicine for treating lupus erythematosus |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102346161A CN102284002A (en) | 2011-08-16 | 2011-08-16 | Traditional Chinese medicine for treating lupus erythematosus |
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| CN102284002A true CN102284002A (en) | 2011-12-21 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117752741A (en) * | 2023-12-30 | 2024-03-26 | 安徽中医药大学第一附属医院(安徽省中医院) | Qi-tonifying yin-nourishing stasis-removing compound traditional Chinese medicine for treating systemic lupus erythematosus-associated immune thrombocytopenia |
-
2011
- 2011-08-16 CN CN2011102346161A patent/CN102284002A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117752741A (en) * | 2023-12-30 | 2024-03-26 | 安徽中医药大学第一附属医院(安徽省中医院) | Qi-tonifying yin-nourishing stasis-removing compound traditional Chinese medicine for treating systemic lupus erythematosus-associated immune thrombocytopenia |
| CN117752741B (en) * | 2023-12-30 | 2024-09-06 | 安徽中医药大学第一附属医院(安徽省中医院) | Qi-tonifying yin-nourishing stasis-removing compound traditional Chinese medicine for treating systemic lupus erythematosus-associated immune thrombocytopenia |
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Application publication date: 20111221 |