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CN102266473A - Chinese medicinal composition for treating systemic lupus erythematosus - Google Patents

Chinese medicinal composition for treating systemic lupus erythematosus Download PDF

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Publication number
CN102266473A
CN102266473A CN2011102346123A CN201110234612A CN102266473A CN 102266473 A CN102266473 A CN 102266473A CN 2011102346123 A CN2011102346123 A CN 2011102346123A CN 201110234612 A CN201110234612 A CN 201110234612A CN 102266473 A CN102266473 A CN 102266473A
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radix
parts
chinese medicine
lupus erythematosus
medicine composition
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CN2011102346123A
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Chinese (zh)
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谢培德
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Chengdu LVDI Technology Co Ltd
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Chengdu LVDI Technology Co Ltd
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Priority to CN2011102346123A priority Critical patent/CN102266473A/en
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Abstract

The invention relates to a Chinese medicinal composition for treating systemic lupus erythematosus. The Chinese medicinal composition comprises the following components in part by weight: 4 to 6 parts of fineleaf schizonepeta herb, 5 to 7 parts of divaricate saposhnikovia root, 8 to 12 parts of gentiana macrophylla, 12 to 18 parts of rehmannia root, 12 to 18 parts of Sinkiang arnebia root, 45 to 55 parts of buffalo horn, 8 to 12 parts of cortex moutan, 8 to 12 parts of red paeony root, 8 to 12 parts of common anemarrhena rhizome, 12 to 18 parts of tuber of multiflower knotweed, 9 to 15 parts of euonymus alatus and 8 to 12 parts of Chinese wolfberry. The Chinese medicinal composition for treating the systemic lupus erythematosus is good in an effect and low in relapse rate, and addresses both symptoms and root causes, and can relieve the pain in patients effectively.

Description

A kind of Chinese medicine composition of therapy system lupus erythematosus
Technical field
The present invention relates to a kind of Chinese medicine, more particularly, relate to a kind of Chinese medicine composition of therapy system lupus erythematosus.
Background technology
Lupus erythematosus is a kind of many organs of health multisystem that involve, complicated clinical manifestation, course of disease delay autoimmune disease repeatedly.
The pathogenesis of lupus erythematosus is not illustrated as yet fully, studies show that in a large number primary disease is a kind of autoimmune disease, can involve health multisystem, many organs, can find multiple autoantibody in patient's blood and organ.Some have the lupus erythematosus patient of inherited genetic factors, under some external world or the effect of inside of human body factor, inspired an immunne response as viral infection, sunlight exposure, psychic trauma, medicine, gestation etc., thereby produce multiple antibody and the immune complex of resisting autologous tissue, cause the human body self tissue, as organ and tissues such as skin, blood vessel, the heart, liver, kidney, brains, malpractice is outbreak repeatedly easily, and each recurrence all might increase the weight of the state of an illness.Western medical treatment systemic lupus erythematosus (sle) adopts hormone more, can't stablize control.Therapeutic effect is not obvious, and it is slow to take effect.Owing to can not get effective alleviation, lupus erythematosus patient stands skin lesion for a long time, arthropathy, and heart, respiratory system also can suffer damage.Clinical characteristics still can be involved vitals such as the heart, kidney simultaneously except that skin lesion is arranged, often with General Symptomies such as heating, joint aches.
Summary of the invention
Problem in view of above-mentioned prior art existence, the Chinese medicine composition that the purpose of this invention is to provide a kind of therapy system lupus erythematosus, it is at the comprehensive cause of disease of lupus erythematosus, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, it is effective, relapse rate is low, treating both the principal and secondary aspects of a disease, has effectively removed patient's slight illness.
In order to address the above problem, the present invention by the following technical solutions: a kind of Chinese medicine composition of therapy system lupus erythematosus, in weight portion, comprise following component: Herba Schizonepetae 4-6, Radix Saposhnikoviae 5-7, Radix Gentianae Macrophyllae 8-12, Radix Rehmanniae 12-18, Radix Arnebiae (Radix Lithospermi) 12-18, Cornu Bubali 45-55, Cortex Moutan 8-12, Radix Paeoniae Rubra 8-12, Rhizoma Anemarrhenae 8-12, winged euonymus 12-18, Radix Polygoni Multiflori 9-15, Fructus Lycii 8-12.
The Analysis on Mechanism of Chinese medicine of the present invention:
Herba Schizonepetae: suffering, tepor.Return lung, Liver Channel.The diffusing wind that induces sweat, rash, the skin ulcer that disappears, hemostasis.Be used for flu, measles is thoroughly sent out not smooth, has blood in stool, metrorrhagia, epistaxis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": control traumatic injury, and deposited skin infection.Control haematemesis.Herba Schizonepetae, all wind of last refresh oneself ends headache, makes eye bright, and separates lung, liver, throat burning pain, and detumescence removes all poison, disperses carbuncle sore.Treating hematochezia ends woman's sudden onset of metrorrhagia, pathogenic wind expelling heat, and logical lung qi nose key plug closes.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion is jerked surely." herbal classic ": main big dizziness due to wind pain, aversion to wind, ailment said due to cold or exposure, blindness does not have finding, is in fashion the whole body, arthralgia numbness, stuffy sensation with restlessness.
Radix Gentianae Macrophyllae: hot, bitter, be slightly cold.Return stomach warp, Liver Channel, gallbladder meridian.Eradicates rheumatism, Shujin network, clearind deficient heat.Be used for rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, infantile malnutrition heating.
The Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.
Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty.GUIXIN, Liver Channel.Removing heat from blood is invigorated blood circulation, the detoxifcation rash.Be used for that heat in blood poison is contained, purple black, the measles without adequate eruption of macule, skin infection, eczema, burn due to hot liquid or fire." detailed outline ": control macule, pox poison, promoting blood circulation and cooling blood, sharp large intestine.
Cornu Bubali: bitter salty, cold.Go into the heart, liver, spleen, stomach four warps.Heat clearing away, removing heat from blood, detoxifcation." Luchuan book on Chinese herbal medicine ": removing pathogenic heat from blood and toxic substance from the body, end nosebleed.Control the calentura stupor, numb pox macule is spitted blood epistaxis, heat in blood, dark coloured urine.
Cortex Moutan: cold in nature, bitter in the mouth; Cool; Be slightly cold.GUIXIN; Liver; Kidney; Lung meridian." must join book on Chinese herbal medicine ": Cortex Moutan, river cypress, the fire in all dewatering, a right clearing away dryness fire, one falls pathogenic fire, declares not to be harmonious.The lid the kidney being adverse to tryness, dry then water is not returned unit, should use Xin Yirun it, cold with clearly it, Cortex Moutan is a power; Kidney is desired hard, and then not hard with burn should be from its property to mend it, and the river cypress is for making.
Radix Paeoniae Rubra: hardship is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.
The Rhizoma Anemarrhenae: bitter, sweet, cold.Return lung, stomach, kidney channel.Clearing away heat-fire promotes the production of body fluid and moisturizes.Shennong's Herbal: main quenching one's thirst pined for, and removes pathogen limbs edema, following water, tonifying for the deficiency, QI invigorating.
Winged euonymus: hardship; Hot; Cold.Return Liver Channel.Removing blood stasis stimulates the menstrual flow; Removing toxic substances and promoting subsidence of swelling." not Lu ": main attacked by pestiferous factors stomachache, remove tapeworm, the skin pathogenic wind toxic that disappears is swollen, makes in the moon and separating.
Radix Polygoni Multiflori Preparata: sweet, puckery, tepor.Return liver, kidney channel.The liver benefiting that nourishes blood, the controlling nocturnal emission with astringent drugs kidney tonifying.
Fructus Lycii: property is flat, sweet in the mouth.Return liver; Kidney; Lung meridian.Nourishing the liver and kidney, replenishing vital essence to improve eyesight." explaining abstruseness of the canon of materia medica ": Fructus Lycii, the kidney invigorating and essence nourishing, the prosperous then bone of water is strong, and quench one's thirst, blurred vision, pain in the lumbar region gonalgia heal invariably.It is flat and not hot to press Fructus Lycii, the energy of moisturizing system fire is arranged, with the same merit of Radix Rehmanniae.
According to the Chinese medicine composition of therapy system lupus erythematosus of the present invention, in the principle of adjusting, balance internal organs, follow the principle of expelling wind and removing dampness, clear nourishing the liver and kidney within its integrated use traditional Chinese medical science, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, mutual reinforcement between are usefulness, the dampness blood stasis dispelling.Herba Schizonepetae, Radix Saposhnikoviae, Radix Gentianae Macrophyllae expelling wind and removing dampness in the side; The Radix Rehmanniae, Cornu Bubali, Cortex Moutan, Radix Paeoniae Rubra, Radix Arnebiae (Radix Lithospermi), the Rhizoma Anemarrhenae, winged euonymus heat clearing away Liang Ying: the Radix Polygoni Multiflori, Fructus Lycii liver-nourishing kidney-boosting, deficiency and excess is taken into account.All medicines are played strengthening vital QI to eliminate pathogenic factors altogether, the merit of dispeiling pathogenic wind and removing dampness, nourishing the liver and kidney, YIN and YANG balance regulating.The therapy system lupus erythematosus, effect is remarkable, double taking stopgap measures originally.
Chinese medicine preparation of the present invention can adopt dosage forms such as tablet, granule, pill, capsule, solution, oral liquid, buccal tablet, granule, electuary, powder, suspensoid, powder, preferably, can adopt solution, tablet, granule and capsule.
Result of use
The treatment group: select experimenter's 20 examples, 10 routine male wherein, 10 routine women, age 30-40 year, take Chinese patent medicine of the present invention twice sooner or later, continue 1 month.
Matched group: select experimenter's 20 examples, 10 routine male wherein, 10 routine women, age 30-40 year, treat with glucocorticoid, continue 1 month.
Judgment criteria:
1. cure: low grade fever disappears, and skin lesion is alleviated, disappeared; Arthralgia obviously alleviates, and focus alleviates, heart, renal system remission;
2. effective: low grade fever, skin lesion goes down, and arthralgia alleviates;
3. invalid: no change, symptom does not have mitigation.
Continued treatment is after 2 courses of treatment, and the result shows, healing number 10 people in the treatment group; Effective number 9 people; Invalid number 1 people, overall effective percentage reaches 95%.And healing number 10 people in the matched group; Effective number 7 people; Invalid number 3 people; Overall effective percentage is 85%, but there is the risk that causes side effect such as steroid diabetes and Cushing's syndrome in matched group.
The specific embodiment
In order to understand the present invention better, the present invention is described below by embodiment.
Embodiment 1
A kind of Chinese medicine composition of therapy system lupus erythematosus in weight portion, comprises following component: Herba Schizonepetae 4, Radix Saposhnikoviae 5, Radix Gentianae Macrophyllae 8, the Radix Rehmanniae 12, Radix Arnebiae (Radix Lithospermi) 12, Cornu Bubali 45, Cortex Moutan 8, Radix Paeoniae Rubra 8, the Rhizoma Anemarrhenae 8, winged euonymus 12, the Radix Polygoni Multiflori 9, Fructus Lycii 8.
Its preparation method is:
In weight portion, get Herba Schizonepetae 4, Radix Saposhnikoviae 5, Radix Gentianae Macrophyllae 8, the Radix Rehmanniae 12, Radix Arnebiae (Radix Lithospermi) 12, Cornu Bubali 45, Cortex Moutan 8, Radix Paeoniae Rubra 8, the Rhizoma Anemarrhenae 8, winged euonymus 12, the Radix Polygoni Multiflori 9, Fructus Lycii 8; Above-mentioned Chinese medicine is cleaned, and decontamination is put into container and is added water and do not have medical material to soak, and after 30 minutes, big fire decocts to boiling, and slow fire was endured 1 hour slowly then; Medicine juice is leached, bag distribution packaging, one bag of 200ml sooner or later respectively obeys one bag, and the dual-purpose medicinal liquid cleans affected part, and 1 month is a course of treatment.
Embodiment 2
A kind of Chinese medicine composition of therapy system lupus erythematosus in weight portion, comprises following component: Herba Schizonepetae 6, Radix Saposhnikoviae 7, Radix Gentianae Macrophyllae 12, the Radix Rehmanniae 18, Radix Arnebiae (Radix Lithospermi) 18, Cornu Bubali 55, Cortex Moutan 12, Radix Paeoniae Rubra 12, the Rhizoma Anemarrhenae 12, winged euonymus 18, the Radix Polygoni Multiflori 15, Fructus Lycii 12.
Its preparation method is:
In weight portion, get Herba Schizonepetae 6, Radix Saposhnikoviae 7, Radix Gentianae Macrophyllae 12, the Radix Rehmanniae 18, Radix Arnebiae (Radix Lithospermi) 18, Cornu Bubali 55, Cortex Moutan 12, Radix Paeoniae Rubra 12, the Rhizoma Anemarrhenae 12, winged euonymus 18, the Radix Polygoni Multiflori 15, Fructus Lycii 12; Cleaning, drying mix above-mentioned medical material, and per kilogram adds about 10L water, and 0.5-1 at a simmer hour, big fire was fried in shallow oil 1-2 hour; Get decocting liquid and cross 150 mesh sieves, the back is concentrated into the clear paste of relative density 1.10-1.20 with concentrator, gets 2/3 clear paste 120 ℃ of following spray dryinges, the clear paste powder, powder is mixed granulation with residue 1/3 clear paste; The packing of granule racking machine promptly gets granule.
Embodiment 3
A kind of Chinese medicine composition of therapy system lupus erythematosus in weight portion, comprises following component: Herba Schizonepetae 5, Radix Saposhnikoviae 6, Radix Gentianae Macrophyllae 10, the Radix Rehmanniae 15, Radix Arnebiae (Radix Lithospermi) 15, Cornu Bubali 50, Cortex Moutan 10, Radix Paeoniae Rubra 10, the Rhizoma Anemarrhenae 10, winged euonymus 15, the Radix Polygoni Multiflori 12, Fructus Lycii 10.
Its preparation method is:
In weight portion, get Herba Schizonepetae 5, Radix Saposhnikoviae 6, Radix Gentianae Macrophyllae 10, the Radix Rehmanniae 15, Radix Arnebiae (Radix Lithospermi) 15, Cornu Bubali 50, Cortex Moutan 10, Radix Paeoniae Rubra 10, the Rhizoma Anemarrhenae 10, winged euonymus 15, the Radix Polygoni Multiflori 12, Fructus Lycii 10; Cleaning, drying mix above-mentioned medical material, and per kilogram adds about 10L water, and 0.5-1 at a simmer hour, big fire was fried in shallow oil 1-2 hour; Get decocting liquid and cross 150 mesh sieves, the back is concentrated into the clear paste of relative density 1.10-1.20 with concentrator, gets 2/3 clear paste 120 ℃ of following spray dryinges, the clear paste powder, powder is mixed granulation with residue 1/3 clear paste; Add suitable adjuvant magnesium stearate, the tablet machine tabletting, coating promptly gets tablet.
Embodiment 4
A kind of Chinese medicine composition of therapy system lupus erythematosus in weight portion, comprises following component: Herba Schizonepetae 5, Radix Saposhnikoviae 6, Radix Gentianae Macrophyllae 10, the Radix Rehmanniae 15, Radix Arnebiae (Radix Lithospermi) 15, Cornu Bubali 50, Cortex Moutan 10, Radix Paeoniae Rubra 10, the Rhizoma Anemarrhenae 10, winged euonymus 15, the Radix Polygoni Multiflori 12, Fructus Lycii 10.
Its preparation method is:
In weight portion, get Herba Schizonepetae 5, Radix Saposhnikoviae 6, Radix Gentianae Macrophyllae 10, the Radix Rehmanniae 15, Radix Arnebiae (Radix Lithospermi) 15, Cornu Bubali 50, Cortex Moutan 10, Radix Paeoniae Rubra 10, the Rhizoma Anemarrhenae 10, winged euonymus 15, the Radix Polygoni Multiflori 12, Fructus Lycii 10; Cleaning, drying mix above-mentioned medical material, and per kilogram adds about 10L water, and 0.5-1 at a simmer hour, big fire was fried in shallow oil 1-2 hour; Get decocting liquid and cross 150 mesh sieves, the back is concentrated into the clear paste of relative density 1.10-1.20 with concentrator, gets 2/3 clear paste 120 ℃ of following spray dryinges, the clear paste powder, powder is mixed granulation with residue 1/3 clear paste; Granule is made the 0.4g/ capsules with the capsule filler.

Claims (4)

1. the Chinese medicine composition of a therapy system lupus erythematosus is characterized in that, in weight portion, comprise following component: Herba Schizonepetae 4-6, Radix Saposhnikoviae 5-7, Radix Gentianae Macrophyllae 8-12, Radix Rehmanniae 12-18, Radix Arnebiae (Radix Lithospermi) 12-18, Cornu Bubali 45-55, Cortex Moutan 8-12, Radix Paeoniae Rubra 8-12, Rhizoma Anemarrhenae 8-12, winged euonymus 12-18, Radix Polygoni Multiflori 9-15, Fructus Lycii 8-12.
2. Chinese medicine composition according to claim 1 is characterized in that, in weight portion, preferably comprises following component: Herba Schizonepetae 5, Radix Saposhnikoviae 6, Radix Gentianae Macrophyllae 10, the Radix Rehmanniae 15, Radix Arnebiae (Radix Lithospermi) 15, Cornu Bubali 50, Cortex Moutan 10, Radix Paeoniae Rubra 10, the Rhizoma Anemarrhenae 10, winged euonymus 15, the Radix Polygoni Multiflori 12, Fructus Lycii 10.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that, described Chinese medicine composition adopts tablet, granule, pill, capsule, solution, oral liquid, buccal tablet, granule, electuary, powder, suspensoid, powder.
4. Chinese medicine composition according to claim 3 is characterized in that, described Chinese medicine composition adopts solution, tablet, granule and capsule.
CN2011102346123A 2011-08-16 2011-08-16 Chinese medicinal composition for treating systemic lupus erythematosus Pending CN102266473A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103263570A (en) * 2013-06-18 2013-08-28 河南中医学院 Chinese medicinal composition for treating systemic lupus erythematosus
CN103920071A (en) * 2014-03-19 2014-07-16 罗金 Subacute cutaneous lupus erythematosus treatment traditional Chinese medicine composition
CN104623388A (en) * 2015-03-13 2015-05-20 南京中医药大学 Traditional Chinese medicine composition for treating systemic lupus erythematosus and preparation method of traditional Chinese medicine composition
CN105125715A (en) * 2015-08-27 2015-12-09 河南中医学院 Traditional Chinese medicinal decoction for treating systemic lupus erythematosus

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103263570A (en) * 2013-06-18 2013-08-28 河南中医学院 Chinese medicinal composition for treating systemic lupus erythematosus
CN103263570B (en) * 2013-06-18 2014-08-06 河南中医学院 Chinese medicinal composition for treating systemic lupus erythematosus
CN103920071A (en) * 2014-03-19 2014-07-16 罗金 Subacute cutaneous lupus erythematosus treatment traditional Chinese medicine composition
CN104623388A (en) * 2015-03-13 2015-05-20 南京中医药大学 Traditional Chinese medicine composition for treating systemic lupus erythematosus and preparation method of traditional Chinese medicine composition
CN104623388B (en) * 2015-03-13 2018-08-21 南京中医药大学 A kind of Chinese medicine composition of systemic lupus erythematosus and preparation method thereof
CN105125715A (en) * 2015-08-27 2015-12-09 河南中医学院 Traditional Chinese medicinal decoction for treating systemic lupus erythematosus
CN105125715B (en) * 2015-08-27 2018-08-24 河南中医学院 A kind of traditional Chinese herbal decoction for systemic lupus erythematosus

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Application publication date: 20111207