CN102266377A - Chinese medicinal composition for treating arrhythmia and preparation method thereof - Google Patents
Chinese medicinal composition for treating arrhythmia and preparation method thereof Download PDFInfo
- Publication number
- CN102266377A CN102266377A CN 201010291044 CN201010291044A CN102266377A CN 102266377 A CN102266377 A CN 102266377A CN 201010291044 CN201010291044 CN 201010291044 CN 201010291044 A CN201010291044 A CN 201010291044A CN 102266377 A CN102266377 A CN 102266377A
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- chinese medicine
- medicine composition
- angelicae sinensis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a Chinese medicinal composition for treating arrhythmia. The Chinese medicinal composition is mainly prepared from raw medicinal herbs such as astragalus, angelica, ginseng, prepared common monkshood daughter root and the like and a pharmaceutically acceptable excipient in a certain weight ratio. The Chinese medicinal composition can be prepared into a formulation of any common oral preparations. The Chinese medicinal composition has the effects of promoting blood circulation, removing obstruction in channels, tonifying qi and consolidating the constitution. Clinical observation indicates that the Chinese medicinal composition has the effects of increasing coronary blood flow, lowering oxygen consumption of myocardium, regulating arrhythmia, improving microcirculation and the like, and can be used for treating arrhythmia.
Description
Invention field
The present invention relates to the ARR Chinese medicine composition of a kind of treatment, belong to the field of Chinese medicines.
Background technology
Arrhythmia is one of common disease clinically of cardiovascular disease, is meant the abnormal change of heart beat rhythm or speed, comprises tachycardia, excessively slow or irregular.Its cause of disease complexity of arrhythmia, clinical manifestation is various, and weight differs, and is mainly in coronary heart disease, myocarditis, hypertensive heart disease etc.Have statistics to show, sudden cardiac death 88% is caused by arrhythmia.At present, obtained major progress, as taked conduit intervene operation or methods such as implantable heart pacer, internal defibrillation device and rhythm of the heart synchronizer to reach prevention and therapeutic purposes though non-medicine mode is treated arrhythmia.But said apparatus costs an arm and a leg, and for the wound treatment is arranged; Part patient such as diabetics, vascular malformation person etc. are unsuitable for installing said apparatus simultaneously, have therefore limited its clinical practice.So antiarrhythmic drug remains the ARR main method of treatment.
This type of arrhythmia of western medical treatment mainly is an anti symptom treatment, based on anticholinergic agents, B-adrenergic receptor analeptic.Common drug is atropine, isoproterenol etc.These drug effect persistent period are short, easily recurrence after the drug withdrawal, and untoward reaction is very big, should not take for a long time.Therefore study that Chinese medicine is significant safely and effectively.
Arrhythmia belongs to categories such as Chinese medicine cardiopalmus, the thoracic obstruction, dizzy retarded pulse.Ancient medicine than system, has been done a large amount of useful work to this sick etiology and pathogenesis and treatment to the understanding of primary disease, and has screened some and have the ARR Chinese medicine of good resistance.So along with progress of science and technology, antiarrhythmic Chinese medicine has obtained everybody and has approved widely.At present the arrhythmia Chinese medicine research is more Radix Sophorae Flavescentis, Radix Ginseng, Rhizoma Coptidis, Cortex Moutan, Radix Glycyrrhizae, Plumula Nelumbinis, Cordyceps, Radix Et Rhizoma Nardostachyos etc., but research at present mostly be single medicinal material greatly, prescription is less, and the Chinese medicine disease is many based on prescription, along with the modern realization of Chinese medicine, the mechanism of action of clear and definite arrhythmia Chinese medicine is sought new action target spot of medicine or new medicine, will provide more wide development field for the Chinese medicine arrhythmia.Compare with Western medicine simultaneously, cheap, natural, the nontoxic or low toxicity untoward reaction of arrhythmia Chinese medicine, be convenient to long-term prescription, for these reasons, the inventor has researched and developed and has been used for the treatment of arrhythmia Chinese medicine composition of the present invention, this Chinese medicine composition has good antiarrhythmic effect, and clinical symptoms also has clear improvement when adjusting heart rate, has improved patient's life quality.
Summary of the invention
Purpose of the present invention aims to provide a kind of determined curative effect, reliable in quality and safe pure Chinese medicine composition, is used for the treatment of arrhythmia.
Another object of the present invention aims to provide a kind of preparation method of above-mentioned Chinese medicine composition.
The objective of the invention is to realize by following manner:
Chinese medicine composition of the present invention is selected Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis and Radix Aconiti Lateralis Preparata are made up by the certain part by weight proportioning, and described compositions can make each efficacy of drugs produce synergism, thereby can effectively treat the outbreak of arrhythmia disease.
The sweet temperature of the wherein selected Radix Astragali, return spleen, lung meridian, gas is thin and distinguish the flavor of densely, can rise and can fall, and the yang aspect of yang is the blood medicine in the gas, but QI invigorating nourish heart, promote blood vessels, strengthen heart rate; And Radix Angelicae Sinensis is sweet and oiliness, goes into heart channel, and the key medicine for enriching blood with blood can increase the supply of heart remarks, reduces myocardial oxygen consumption, and protecting myocardial cell is so the present invention share that blood is brought about the desired sensation and the speed life with the two, benefiting QI for activating blood circulation; And the big heat of Radix Aconiti Lateralis Preparata Da Xin, the current twelve regular channels, warm tonifying YANG gas is mended congenital greatly; Radix Ginseng is sweet and tepor is returned spleen, lung meridian, and the vigour of big spleen reinforcing lung is with Gu Houtian, with the same usefulness of Radix Aconiti Lateralis Preparata, then can the QI invigorating sun with YANG invigorating.The event compatibility can be played benefiting QI for activating blood circulation, the effect of the YANG invigorating of promoting blood circulation altogether, thus promote blood vessels make the blood stickiness be improved significantly, protecting myocardial cell and adjust heart rate is so can reach the effect for the treatment of arrhythmia.
In order to reach better therapeutic, the present composition also can will add the Radix Rehmanniae and Rhizoma Dioscoreae.Wherein Radix Rehmanniae sweetness and bitterness is cold, GUIXIN, liver, lung meridian, and big tonifying kidney-yin, beneficial essence are filled out marrow with high nourishing YIN blood, so have certain heart tonifying, the effect of diuresis, the while can prevent that Radix Ginseng, Radix Aconiti Lateralis Preparata are overheated; The Rhizoma Dioscoreae abnormal smells from the patient is gentle, go into lung, spleen channel, temperature compensation and not rapid, little perfume (or spice) and not dry is the good medicine of spleen invigorating QI invigorating, the function of tool antioxidation and adjusting immunity, so the two can make cloudy blood get above living reinforcing the heart, tonifying both YIN and YANG can help the above-mentioned medicine of respectively distinguishing the flavor of to play the merit of benefiting QI and nourishing blood, heart tonifying the kidney invigorating altogether, so can adjust heart rate, reach the merit of treatment arrhythmia.So all medicines share better efficacy, are treating both the principal and secondary aspects of a disease, are used for the treatment of the arrhythmia disease, have optimum curative effect.
The consumption of each crude drug component of Chinese medicine composition of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components is that (all in weight portion) has better curative effect in the following weight parts scope:
3～90 parts of the Radixs Astragali, 2～85 parts of Radix Angelicae Sinensis, 1～90 part of Radix Ginseng.
Be preferably 2～6 parts of 1～3 part of Radix Ginseng, 13～16 parts of the Radixs Astragali and Radix Angelicae Sinensis.
Most preferably be: 4 parts of 2 parts of Radix Ginsengs, 10 parts of the Radixs Astragali and Radix Angelicae Sinensis.
Chinese medicine composition of the present invention can also add Radix Aconiti Lateralis Preparata, and each crude drug component of Chinese medicine composition promptly of the present invention (all in weight portion) in the following weight parts scope has better curative effect:
1～20 part of 3～90 parts of the Radixs Astragali, 2～85 parts of Radix Angelicae Sinensis, 1～90 part of Radix Ginseng and Radix Aconiti Lateralis Preparata.
Be preferably: 1～3 part of 13～16 parts of the Radixs Astragali, 2～6 parts of Radix Angelicae Sinensis, 1～3 part of Radix Ginseng and Radix Aconiti Lateralis Preparata.
Most preferably be: 2 parts of 10 parts of the Radixs Astragali, 4 parts of Radix Angelicae Sinensis, 2 parts of Radix Ginsengs and Radix Aconiti Lateralis Preparata.
The preparation method of Chinese medicine composition of the present invention is as follows:
Take by weighing each crude drug by above-mentioned weight portion: the Radix Astragali, Radix Angelicae Sinensis, Radix Ginseng and Radix Aconiti Lateralis Preparata; Radix Ginseng and Radix Angelicae Sinensis are extracted 1～3 time with alcohol reflux, and each alcohol adding amount is 5～10 times, and each extraction time is 1～3 hour, and merge extractive liquid, filters, and filtrate is reclaimed alcohol, and concentrating under reduced pressure is clear paste, and is standby; With the Radix Astragali and Radix Aconiti Lateralis Preparata extracting in water 1～3 time, each amount of water is 5～8 times, and each extraction time is 1～3 hour, merge extractive liquid,, filter, the clear paste that filtrate adding Radix Ginseng, Radix Angelicae Sinensis mixed extraction obtain, concentrating under reduced pressure is a thick paste again, drying under reduced pressure, pulverize, drying promptly gets Chinese medicine composition active component of the present invention, the last an amount of excipient that suits that adds again is prepared into pharmaceutically various pharmaceutical preparatioies.
The crude drug of Chinese medicine composition of the present invention can also add the Radix Rehmanniae and Rhizoma Dioscoreae, and each crude drug component of Chinese medicine composition promptly of the present invention (all in weight portion) in the following weight parts scope has optimum curative effect:
2～90 parts of 3～90 parts of the Radixs Astragali, 2～85 parts of Radix Angelicae Sinensis, 1～90 part of Radix Ginseng, 1～20 part of Radix Aconiti Lateralis Preparata, 1～90 part in the Radix Rehmanniae and Rhizoma Dioscoreaes.
Be preferably: 3～7 parts of 8～16 parts of the Radixs Astragali, 2～6 parts of Radix Angelicae Sinensis, 1～3 part of Radix Ginseng, 1～3 part of Radix Aconiti Lateralis Preparata, 1～3 part in the Radix Rehmanniae and Rhizoma Dioscoreaes.
Most preferably be: 5 parts of 10 parts of the Radixs Astragali, 4 parts of Radix Angelicae Sinensis, 2 parts of Radix Ginsengs, 2 parts of Radix Aconiti Lateralis Preparata, 2 parts in the Radix Rehmanniae and Rhizoma Dioscoreaes.
Chinese medicine composition of the present invention can also prepare as follows and get:
Take by weighing each crude drug by above-mentioned weight portion; Radix Ginseng and Radix Angelicae Sinensis are extracted 1～3 time with alcohol reflux, and each alcohol adding amount is 5～10 times, and each extraction time is 1～3 hour, and merge extractive liquid, filters, and filtrate is reclaimed alcohol, and concentrating under reduced pressure is clear paste, and is standby; With the Radix Astragali, the Radix Rehmanniae, Rhizoma Dioscoreae and Radix Aconiti Lateralis Preparata extracting in water 1～3 time, each amount of water is 5～8 times, each extraction time is 1～3 hour, merge extractive liquid, filters, and concentrating under reduced pressure is a thick paste behind the clear paste of filtrate adding Radix Ginseng, Radix Angelicae Sinensis mixed extraction, drying under reduced pressure, pulverize, drying promptly gets the active component of Chinese medicine composition of the present invention; Add suitable excipient again and be prepared into pharmaceutical preparation.
The granule of Chinese medicine composition of the present invention can prepare as follows:
Take by weighing each crude drug by weight: 5 parts of 10 parts of the Radixs Astragali, 4 parts of Radix Angelicae Sinensis, 2 parts of Radix Ginsengs, 2 parts of Radix Aconiti Lateralis Preparata, 2 parts in the Radix Rehmanniae and Rhizoma Dioscoreaes; With 70% alcohol reflux 2 times, alcohol adding amount is 8 times for the first time, extracts 2 hours with Radix Ginseng and Radix Angelicae Sinensis, and the second time, alcohol adding amount was 6 times, extracted 1.5 hours, and merged the extracting solution of twice gained, filter, filtrate is reclaimed alcohol, is evaporated to relative density and is the clear paste of 1.08～1.10 (60 ℃), and is standby; With the Radix Astragali, the Radix Rehmanniae, Rhizoma Dioscoreae and Radix Aconiti Lateralis Preparata extracting in water 2 times, each amount of water is 6 times again, and each extraction time is 2 hours, merge extractive liquid,, filter, filtrate is evaporated to the thick paste that relative density is 1.25～1.30 (60 ℃), drying under reduced pressure after adding Radix Ginseng and Radix Angelicae Sinensis mixed extraction gained clear paste, pulverize, add suitable an amount of medicinal granule excipient, mixing is granulated, drying promptly gets the granule of Chinese medicine composition of the present invention.
The preferred Radix Ginseng Rubra of selected crude drug Radix Ginseng in the present composition, the preferred Radix Astragali of the Radix Astragali.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral formulations.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these raw materials decocting together, the condensed water decocting liquid is made then; Can also bring into play drug effect better for each raw material that makes this medicine, preferably Radix Ginseng in the crude drug etc. be carried out special extraction such as ethanol extraction etc.But these all can not be used to limit protection scope of the present invention.
The active component of medicine of the present invention can add various conventional excipients required when preparing different dosage form, as disintegrating agent, lubricant, binding agent etc., and be prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine, as pill, powder, tablet, capsule, granule and oral liquid etc.
Chinese medicine composition of the present invention has the effect that promoting blood circulation to remove obstruction in the collateral, QI invigorating consolidate, and clinical observation shows that the present invention can increase coronary flow, reduce myocardium keto consumption, can adjust arrhythmia and improve the effect etc. of plan circulation, can be used for treating the disease of arrhythmia.
The oral effective daily dose of the present invention is 20～105g raw medicinal herbs, divides and takes for 2～3 times.
In order to verify the drug effect of Chinese medicine composition of the present invention, the inventor has carried out the pharmacodynamic study of rat myocardial ischemia and reperfusion injury protection effect is tested to Chinese medicine composition of the present invention:
Materials and methods:
Laboratory animal: totally 50 of the Wistar rats that provides by Hu'nan Inst. of Plarmaceutical Industry, male and female half and half, body weight 240 ± 20g is divided into 5 groups at random.
Experimental drug: Chinese medicine composition 1 of the present invention (formulated), Chinese medicine composition of the present invention 2 (formulated) and Chinese medicine composition of the present invention 2 (10 parts of the Radixs Astragali, 4 parts of Radix Angelicae Sinensis, 2 parts of Radix Ginsengs, 2 parts of Radix Aconiti Lateralis Preparata, 2 parts in the Radix Rehmanniae and 5 parts of Rhizoma Dioscoreaes are formulated) by 10 parts of the Radixs Astragali, 4 parts of Radix Angelicae Sinensis, 2 parts of Radix Ginsengs and 2 parts of Radix Aconiti Lateralis Preparata by 10 parts of the Radixs Astragali, 4 parts of Radix Angelicae Sinensis and 2 parts of Radix Ginsengs.
Experimental technique: 1, myocardial ischemia-reperfusion Preparation of model: urethane anesthesia (1g/1kg), monitoring limb lead electrocardiogram.Separate trachea and intubate, open and go miniature artificial respirator positive pressure respiration behind the breast immediately, except that propping up following the not ligation of threading chamber, a normal control group arteria coronaria left side, prop up chambers, three groups of equal ligation arteria coronaria left sides in addition.With ECG ST section after the ligation obviously raise 〉=Q15mV is a ligation success standard.During ligation with a tiny latex pipe pad between blood vessel and ligature; Ligation was loosened after 30 minutes, and ligature is capable to be poured into 60 minutes again.When pine is pricked each group all with constant flow pump through normal saline, the present composition 1 or the present composition 2 normal saline solutions of capacity such as femoral vein average rate input (10ml/100g, 1.0ml/min); 2, cardiac muscular tissue's homogenized: pour into 60min again and take out heart immediately,, blot, weigh, make the normal saline homogenate of 10% cardiac muscular tissue with Potter-Elvehjem Tissue Grinders with the ice normal saline flushing; 3, measure: dabblingly again observe electrocardiogram simultaneously and write down the variation of respectively organizing arrhythmia generation and persistent period, perfusion 15 minutes and 60 minutes ST sections in 30 minutes.
Experimental result: occur severe arrhythmia after matched group pours into again very soon, the time that Chinese medicine composition group arrhythmia of the present invention occurs obviously postpones, the arrhythmia persistent period obviously shortens, VT, VF incidence rate significantly reduce, and the ST section is raised degree and all significantly is lower than matched group when irritating 15min and 60min again.See following table for details.
Chinese medicine composition of the present invention is to pouring into the influence of arrhythmia and ST section again
In order to verify the effectiveness of Chinese medicine composition of the present invention to human body, the inventor has carried out the clinical research test to Chinese medicine composition curative effect of the present invention:
The inventor utilizes granule 2 each 60 example of treatment cardiac arrhythmia of the granule 1 and embodiment 7 gained of embodiment 1 gained in the specific embodiment, compares with precious pill for curing 60 examples of the heart, tests as follows:
The inventor is in hospital in the intracardiac section in Hunan Inst of Traditional Chinese Medicine and reaches patient's 180 examples of having selected to meet following condition among the out-patient: clinical manifestation is cardiopalmus, uncomfortable in chest, dizzy, weak; Its heart rate of having an electro-cardiogram when checking is per minute and surpasses 1 minute person less than 55 times, persistent period.Wherein male 92 examples, women 88 examples, the age is 45～70 years old, the mean age is 60 years old.Take the table of random number method to be divided into three groups at random.Treat one group of (taking embodiment 1 granule) 60 example, male 31 examples, women 29 examples; Wherein protopathy has coronary heart disease 30 examples, myocarditis 15 examples and cardiomyopathy 7 examples, other 8 examples; Treat two groups of (taking embodiment 7 granules) 60 examples, male 27 examples, women 33 examples; Wherein protopathy has coronary heart disease 42 examples, myocarditis 7 examples and cardiomyopathy 9 examples, other 2 examples; Matched group 60 examples, male 34 examples, women 26 examples, protopathy have coronary heart disease 31 examples, myocarditis 12 examples and cardiomyopathy 10 examples, other 7 examples.Two groups of patients have comparability in the difference that compares aspect age, sex, the cause of disease that there are no significant.Cooperate conventional suiting the medicine to the illness to support and the protopathy treatment when inventor takes following Therapeutic Method to treat to three groups of patients, all treat a course of treatment, relatively three groups curative effect.
The treatment group: medicinal granule of the present invention, use warm boiled water, take 10g at every turn, every day 23 times, 2 weeks were 1 course of treatment.
Matched group: the precious ball (Guangdong Taiantang Pharmaceutical Co., Ltd) of the heart, 4/time, oral every day 3 times, 2 weeks were 1 course of treatment.
Criterion of therapeutical effect: with reference to national prevention and treatment in Chinese and western coronary heart disease and arrhythmia research forum revised standard in 1989.Produce effects: clinical symptoms is obviously improved or is disappeared, and the heart rate per minute is greater than 60 times, has an electro-cardiogram when checking electrocardiogram normally or normal substantially; Effectively: clinical symptoms alleviates to some extent, and heart rate per minute before increases by 5 to 10 times, and having an electro-cardiogram, electrocardiogram makes moderate progress before when checking; Invalid: clinical symptoms does not have improvement, the heart rate no change or change trickle be heart rate before the per minute increase be less than 5 times, electrocardiogram does not also have change.
Judge that according to above-mentioned curative effect diagnostic criteria the present composition is better to ARR curative effect.Therapeutic outcome sees the following form:
Treatment group and matched group curative effect be (p＜0.01) relatively
The specific embodiment
Embodiment 1, granule of the present invention
Take by weighing Radix Angelicae Sinensis 180g, Radix Astragali 440g, Radix Ginseng 90g, Radix Rehmanniae 90g, Rhizoma Dioscoreae 220g and Radix Aconiti Lateralis Preparata 90g respectively, as follows preparation cost invention granule:
A, with the Radix Ginseng that taken by weighing and Radix Angelicae Sinensis with 70% alcohol reflux 2 times, alcohol adding amount is 8 times for the first time, extracted 2 hours, alcohol adding amount is 6 times for the second time, extracted 1.5 hours, and merged the extracting solution of twice gained, filter, filtrate is evaporated to the clear paste that relative density is 1.08～1.10 (60 ℃) after reclaiming alcohol, and is standby;
B, the Radix Astragali, the Radix Rehmanniae, Rhizoma Dioscoreae and Radix Aconiti Lateralis Preparata extracting in water 2 times with being taken by weighing, each amount of water is 6 times, each extraction time is 2 hours, merge extractive liquid, filters, and filtrate adds above-mentioned A step gained clear paste, and be evaporated to the thick paste that relative density is 1.25～1.30 (60 ℃), drying under reduced pressure is pulverized, and gets dry extract;
C, B step institute got dry extract adds suitable an amount of medicinal granule excipient, granulates, and drying, subpackage promptly gets granule 1000 of the present invention and wraps.
Embodiment 2, tablet of the present invention
Take by weighing Radix Ginseng 45g, Radix Angelicae Sinensis 90g, Radix Astragali 700g, Radix Rehmanniae 45g, Rhizoma Dioscoreae 135g and Radix Aconiti Lateralis Preparata 45g respectively, as follows preparation cost invention tablet.
A, get the fixed Radix Ginseng of above-mentioned title and Radix Angelicae Sinensis powder is broken into coarse powder, 60% the ethanol that adds 8 times, 5 times, 5 times respectively, reflux, extract, 3 times, each extracted 1 hour, 1 hour and 0.5 hour, filter, merge three times extracting solution, filtrate is evaporated to the clear paste that relative density is 1.12～1.15 (60 ℃) after reclaiming alcohol, and is standby;
B, the Radix Astragali, the Radix Rehmanniae, Rhizoma Dioscoreae and the Radix Aconiti Lateralis Preparata that above-mentioned title is fixed add 8 times of water extraction 1 time, and extraction time is 3 hours, and extracting solution filters, filtrate adds above-mentioned A step gained clear paste and is evaporated to the thick paste that relative density is 1.35～1.40 (60 ℃), drying under reduced pressure is pulverized, and gets dry extract;
C, B step institute got dry extract adds suitable an amount of medicinal tablets excipient, granulation, and drying, tabletting promptly gets 1000 in tablet of the present invention.
Embodiment 3, medicine capsule of the present invention
Take by weighing Radix Ginseng 130g, Radix Astragali 350g, Radix Angelicae Sinensis 260g, Radix Rehmanniae 130g, Rhizoma Dioscoreae 310g and Radix Aconiti Lateralis Preparata 130g respectively, be prepared into granule as follows:
A, get the fixed Radix Ginseng of above-mentioned title and Radix Angelicae Sinensis powder is broken into coarse powder, add 75% alcohol reflux 2 times of 10 times and 5 times respectively, 3 hours for the first time, 1 hour for the second time, extracted twice liquid is merged filtration, and filtrate is concentrated into the clear paste that relative density is 1.10～1.12 (60 ℃), and is standby;
B, get the fixed Radix Astragali of above-mentioned title, the Radix Rehmanniae, Rhizoma Dioscoreae and Radix Aconiti Lateralis Preparata and add 5 times in water, 6 times and 8 times respectively and respectively extracted 1 hour, merge extractive liquid, filters, filtrate adds A step gained clear paste and is evaporated to the thick paste that relative density is 1.50～1.55 (60 ℃), drying under reduced pressure is pulverized, and gets dry extract;
C, B step institute got dry extract adds suitable an amount of glue,medicinal wafer excipient, granulates, and drying pours into gelatine capsule shell, gets 1000 of capsules of the present invention.
Embodiment 4, medicinal granule of the present invention
Take by weighing Radix Ginseng 135g, Radix Angelicae Sinensis 270g, Radix Astragali 450g respectively, preparation cost invention granule as follows: get the fixed Radix Ginseng of above-mentioned title, Radix Angelicae Sinensis and astragalus membranaceus powder and be broken into coarse powder, add 8 times and 10 times of water extraction respectively 2 times, each 2 hours, merge extractive liquid,, filter, filtrate decompression is condensed into dry extract, pulverizes drying, add suitable an amount of medicinal granule excipient, preparation cost invention granule 1000 bags.
Embodiment 5, medicine buccal tablet of the present invention
Take by weighing Radix Ginseng 50g, Radix Angelicae Sinensis 300g and Radix Astragali 400g respectively, as follows preparation cost invention buccal tablet:
Get fixed Radix Ginseng of above-mentioned title and Radix Angelicae Sinensis and add and 70% alcohol reflux of raw material equivalent 3 hours, extracting solution filters, and filtrate is reclaimed alcohol, will filter the notes concentrating under reduced pressure and become dry extract standby; The astragalus membranaceus powder that above-mentioned title is fixed is broken into coarse powder, adds 5 times and 8 times of water extraction respectively 2 times, extracts 2 hours for the first time, extracts 1 hour for the second time, merge extractive liquid, filters, and filtrate decompression is condensed into dry extract, pulverizes, drying adds suitable an amount of buccal tablet excipient, 1000 of preparation cost invention buccal tablets.
Embodiment 6, medicament pellet capsule of the present invention
Take by weighing Radix Ginseng 90g, Radix Angelicae Sinensis 180g and Radix Astragali 540g respectively, as follows preparation cost invention pellet capsule:
Get the fixed Radix Ginseng of above-mentioned title, Radix Angelicae Sinensis and astragalus membranaceus powder and be broken into coarse powder, add 10 times, 8 times and 5 times of water extraction respectively 3 times, extracted 2 hours for the first time, extracted 1 hour for the second time, extracted for the third time 1 hour, merge three times the gained extracting solution, filter, filtrate decompression is condensed into dry extract, pulverizes, dry, adopt conventional microsphere and its preparation, add an amount of suitable excipient, be prepared into the pastille micropill after, micropill is filled in the gelatine capsule 1000 of preparation cost invention pellet capsules.
Embodiment 7, granule of the present invention
Take by weighing Radix Angelicae Sinensis 270g, Radix Astragali 720g, Radix Ginseng Rubra 135g and Radix Aconiti Lateralis Preparata 135g respectively, as follows preparation cost invention granule:
A, with the Radix Ginseng that taken by weighing and Radix Angelicae Sinensis with 70% alcohol reflux 3 times, alcohol adding amount is 10 times for the first time, extracted 2 hours, for the second time and for the third time alcohol adding amount is 8 times respectively, each extracted 1 hour, merged the extracting solution of three gained, filtered, filtrate is evaporated to the clear paste that relative density is 1.10～1.15 (60 ℃) after reclaiming alcohol, and is standby;
B, with the Radix Astragali that taken by weighing and Radix Aconiti Lateralis Preparata extracting in water 2 times, each amount of water is 5 times, each extraction time is 3 hours, merge extractive liquid,, filter, filtrate adds above-mentioned A step gained clear paste and is evaporated to the thick paste that relative density is 1.45～1.50 (60 ℃), drying under reduced pressure, pulverize, get dry extract;
C, B step institute got dry extract adds suitable an amount of medicinal granule excipient, granulates, and drying, subpackage promptly gets granule 1000 of the present invention and wraps.
Embodiment 8, capsule of the present invention
Take by weighing Radix Angelicae Sinensis 160g, Radix Astragali 640g, Radix Ginseng 160g and Radix Aconiti Lateralis Preparata 80g respectively, add suitable an amount of glue,medicinal wafer excipient after pressing the dried cream of embodiment 6 preparation cost invention active component, granulate drying, pour in the gelatine capsule, promptly get 1000 of capsules of the present invention.
Embodiment 9, tablet of the present invention
Take by weighing Radix Angelicae Sinensis 180g, Radix Astragali 720g, Radix Ginseng 60g and Radix Aconiti Lateralis Preparata 120g respectively, press and add suitable an amount of medicinal tablets excipient behind the dried cream of embodiment 6 preparation cost invention active component, granulate, drying, tabletting promptly gets 1000 in tablet of the present invention.
Claims (10)
1. the ARR Chinese medicine composition of treatment is characterized in that described Chinese medicine composition mainly is made up of 3～90 parts of the following bulk drugs Radixs Astragali, 2～85 parts of Radix Angelicae Sinensis and 1～90 part of Radix Ginseng and/or the acceptable excipient of pharmacy.
2. Chinese medicine composition according to claim 1 is characterized in that the weight portion of described crude drug is respectively: 1～3 part of 8～16 parts of the Radixs Astragali, 2～6 parts of Radix Angelicae Sinensis and Radix Ginseng.
3. Chinese medicine composition according to claim 2 is characterized in that the weight portion of described crude drug is respectively: 2 parts of 10 parts of the Radixs Astragali, 4 parts of Radix Angelicae Sinensis and Radix Ginsengs.
4. the preparation method of each described Chinese medicine composition of claim 1～3, it may further comprise the steps:
A, by claim 1,2 or 3 described each weight portion weighting raw materials Radix Astragali, Radix Angelicae Sinensis and Radix Ginseng;
B, Radix Ginseng and Radix Angelicae Sinensis are extracted 1～3 time with alcohol reflux, each alcohol adding amount is 5～10 times, and each extraction time is 1～3 hour, and merge extractive liquid, filters, and filtrate is reclaimed alcohol, and concentrating under reduced pressure is clear paste, and is standby;
C, Radix Astragali extracting in water 1～3 time, each amount of water is 5～8 times, each extraction time is 1～3 hour, merge extractive liquid,, filter, filtrate adds above-mentioned B step gained clear paste and concentrating under reduced pressure is a thick paste, drying under reduced pressure, pulverize, drying promptly gets Chinese medicine composition active component of the present invention.
D, the Chinese medicine composition active component of the present invention of C gained is added suitable excipient be prepared into pharmaceutical preparation.
5. Chinese medicine composition according to claim 1 is characterized in that described Chinese medicine composition also has following bulk drugs: 1～20 part of Radix Aconiti Lateralis Preparata.
6. Chinese medicine composition according to claim 5 is characterized in that described Chinese medicine composition also has following bulk drugs: 2～90 parts of 1～90 part in the Radix Rehmanniae and Rhizoma Dioscoreaes.
7. Chinese medicine composition according to claim 6 is characterized in that described Chinese medicine composition is made up of 8～16 parts of the following bulk drugs Radixs Astragali, 2～6 parts of Radix Angelicae Sinensis, 1～3 part of Radix Ginseng, 1～3 part of Radix Aconiti Lateralis Preparata, 1～3 part in the Radix Rehmanniae and 3～7 parts of Rhizoma Dioscoreaes and/or the acceptable excipient of pharmacy.
8. Chinese medicine composition according to claim 7 is characterized in that the weight portion of described crude drug is respectively: 5 parts of 10 parts of the Radixs Astragali, 4 parts of Radix Angelicae Sinensis, 2 parts of Radix Ginsengs, 2 parts of Radix Aconiti Lateralis Preparata, 2 parts in the Radix Rehmanniae and Rhizoma Dioscoreaes.
9. the preparation method of claim 6 or 7 described Chinese medicine compositions, it may further comprise the steps:
A, according to claim 6 or 7 described each crude drug that take by weighing by weight;
B, Radix Ginseng and Radix Angelicae Sinensis are extracted 1～3 time with alcohol reflux, each alcohol adding amount is 5～10 times, and each extraction time is 1～3 hour, and merge extractive liquid, filters, and filtrate is reclaimed alcohol, and concentrating under reduced pressure is clear paste, and is standby;
C, the Radix Astragali, the Radix Rehmanniae, Rhizoma Dioscoreae and Radix Aconiti Lateralis Preparata extracting in water 1～3 time, each amount of water is 5～8 times, each extraction time is 1～3 hour, merge extractive liquid, filters, and filtrate adds above-mentioned B step gained clear paste and concentrating under reduced pressure is a thick paste, drying under reduced pressure, pulverize, drying promptly gets the active component of Chinese medicine composition of the present invention.
D, the Chinese medicine composition active component of the present invention of C gained is added suitable excipient be prepared into pharmaceutical preparation.
10. according to claim 1 to 9 a described Chinese medicine composition, it is characterized in that the granule of described Chinese medicine composition prepares as follows:
A, take by weighing each crude drug by weight: 5 parts of 10 parts of the Radixs Astragali, 4 parts of Radix Angelicae Sinensis, 2 parts of Radix Ginsengs, 2 parts of Radix Aconiti Lateralis Preparata, 2 parts in the Radix Rehmanniae and Rhizoma Dioscoreaes;
B, with Radix Ginseng and Radix Angelicae Sinensis with 70% alcohol reflux 2 times, alcohol adding amount is 8 times for the first time, extracted 2 hours, alcohol adding amount is 6 times for the second time, extracts 1.5 hours, merges the extracting solution of twice gained, filter, filtrate is reclaimed alcohol, is evaporated to relative density and is the clear paste of 1.08～1.10 (60 ℃), and is standby;
C, the Radix Astragali, the Radix Rehmanniae, Rhizoma Dioscoreae and Radix Aconiti Lateralis Preparata extracting in water 2 times, each amount of water is 6 times, each extraction time is 2 hours, merge extractive liquid,, filter, filtrate adds above-mentioned B step gained clear paste and is evaporated to the thick paste that relative density is 1.25～1.30 (60 ℃), drying under reduced pressure, pulverize, add suitable medicinal granule excipient, mixing is granulated, drying promptly gets the granule of Chinese medicine composition of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010291044 CN102266377A (en) | 2010-06-07 | 2010-09-17 | Chinese medicinal composition for treating arrhythmia and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010193290.8 | 2010-06-07 | ||
| CN201010193290 | 2010-06-07 | ||
| CN 201010291044 CN102266377A (en) | 2010-06-07 | 2010-09-17 | Chinese medicinal composition for treating arrhythmia and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102266377A true CN102266377A (en) | 2011-12-07 |
Family
ID=45048961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010291044 Pending CN102266377A (en) | 2010-06-07 | 2010-09-17 | Chinese medicinal composition for treating arrhythmia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102266377A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768172A (en) * | 2012-09-23 | 2014-05-07 | 季旭明 | Traditional Chinese medicine for improving cancer cachexia life quality and preparation method thereof |
| CN104758553A (en) * | 2015-04-17 | 2015-07-08 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating arrhythmia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1383846A (en) * | 2001-04-29 | 2002-12-11 | 王运景 | Heart-strengthening and blood circulation-promoting liquid medicine for treating heart diseases |
-
2010
- 2010-09-17 CN CN 201010291044 patent/CN102266377A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1383846A (en) * | 2001-04-29 | 2002-12-11 | 王运景 | Heart-strengthening and blood circulation-promoting liquid medicine for treating heart diseases |
Non-Patent Citations (2)
| Title |
|---|
| 《中国民族民间医药》 20090115 黎裕朝 中医药治疗缓慢性心律失常近况 50-51 1-10 , 第01期 * |
| 《河北中医》 19970527 徐文阁等 从肾论治缓慢性心律失常36例 27 1-10 第19卷, 第03期 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768172A (en) * | 2012-09-23 | 2014-05-07 | 季旭明 | Traditional Chinese medicine for improving cancer cachexia life quality and preparation method thereof |
| CN104758553A (en) * | 2015-04-17 | 2015-07-08 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating arrhythmia |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1970069B (en) | Chinese medicinal pill for treating coronary heart disease | |
| CN101104048B (en) | Compound medicine for pulse generating and treating coronary heart disease | |
| WO2007006203A1 (en) | A capsule formulation for treating hypertension and coronary heart disease and process for preparation thereof | |
| CN112641915A (en) | Traditional Chinese medicine ointment formula for treating palpitation and preparation method thereof | |
| CN101095768B (en) | Chinese traditional medicine capsule for treating primary hypertension for persons in middle and old age | |
| CN101088546A (en) | Heart-benefiting Yixinshu micropill and its prepn process | |
| CN101099775B (en) | Cardiac and cerebral vascular disease treating medicine | |
| CN102266377A (en) | Chinese medicinal composition for treating arrhythmia and preparation method thereof | |
| CN102293923B (en) | Application of Tibetan medicinal composition to preparation of medicament for preventing and treating osteoporosis | |
| CN1970050B (en) | Pharmaceutical composition for treating arrhythmia and preparation process thereof | |
| CN104707023A (en) | Traditional Chinese medicinal composition for treating polycystic ovary syndrome, and preparation method thereof | |
| CN108721572B (en) | A Chinese medicinal composition for treating hepatocarcinoma and liver cirrhosis | |
| CN102988938A (en) | Traditional Chinese medicine composition for treating arrhythmia or atrial fibrillation and preparation method thereof | |
| CN101757423B (en) | Traditional Chinese medicine composition for treating myocarditis and preparation method thereof | |
| CN100394947C (en) | Pharmaceutical composition and preparation method for treating cervical spondylosis | |
| CN101020002B (en) | Compound Chinese medicine preparation for assisting tumor radiotherapy and its preparation method | |
| CN101176751B (en) | Pharmaceutical composition of red sage root and cassia twig | |
| CN101721598A (en) | Traditional Chinese medicine composition for treating liver diseases and preparation method and application thereof | |
| CN109364113A (en) | A kind of composition and purposes of resveratrol and Chinese medical extract | |
| CN101152247A (en) | Pharmaceutical composition for cardiovascular and cerebrovascular diseases and method for preparing the same | |
| CN101658568B (en) | Application of Chinese medicinal composition in preparing medicament for treating pulmonary heart disease | |
| CN108114106A (en) | A kind of Chinese medicine composition of relaxing tendons and activating collaterals dispersing blood stasis analgesic and preparation method thereof | |
| CN105477384A (en) | Traditional Chinese medicine composition capable of reducing blood pressure and preparation method of composition | |
| CN106138795A (en) | Chinese medicine composition for the treatment of premature beat and preparation method thereof | |
| CN104435153A (en) | Traditional Chinese medicine composition for treating hypertension and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20111207 |