CN102217598A - Composition containing niclosamide and metaldehyde and compound suspension thereof - Google Patents
Composition containing niclosamide and metaldehyde and compound suspension thereof Download PDFInfo
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- CN102217598A CN102217598A CN2011100977906A CN201110097790A CN102217598A CN 102217598 A CN102217598 A CN 102217598A CN 2011100977906 A CN2011100977906 A CN 2011100977906A CN 201110097790 A CN201110097790 A CN 201110097790A CN 102217598 A CN102217598 A CN 102217598A
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Abstract
The invention discloses a composition containing niclosamide and metaldehyde and a compound suspension thereof. The niclosamide and the metaldehyde are used as active ingredients of the composition, and the mass ratio of the niclosamide to the metaldehyde is (1-50):(1-10). The composition can be applied to preparation of medicaments for preventing and treating trematodiasis. The aqueous suspension containing the niclosamide and the metaldehyde comprises 1-50 percent of niclosamide, 1-10 percent of metaldehyde, 1-5 percent of wetting agent, 1-20 percent of dispersant, 1-10 percent of anti-freezing agent, 0.1-1 percent of preservative, 0.1-1 percent of pH regulator, 0.1-1 percent of defoaming agent, 0.1-2 percent of thickening agent and the balance of deionized water which complements the volume to 100 percent. The aqueous suspension has the advantages of large prevention and treatment spectrum, good oncomelania killing effect, nonuse of an organic solvent, low volatility, low toxicity, safety to people, animals and environments, low granularity, high suspension rate, convenience in use and obvious comprehensive and economic benefits.
Description
Technical field
The invention belongs to the blood fluke prevention and control field, be specifically related to a kind of composition that contains the niclosamide and the methaldehyde with and aqueous suspension agent.
Background technology
The niclosamide and the methaldehyde are mainly used in popular with the prevention and control bilharziasis of mollusk extremely.Niclosamide stimulates the aerobic metabolism of oncomelania when low concentration, promote the escape of oncomelania and swash, and influences tricarbonic acid cycle during high concentration and causes oncomelania death; The methaldehyde also is a kind of application molluscacide very widely, and its outstanding advantage is can suppress oncomelania to swash, and is low to aquatile toxicity.
But the problem that both all exist medication difficulty and pesticide resistance to produce is difficult to effectively control the popular of schistosomiasis.And the two is the medicine that is insoluble in water, and its wetting powder drug effect is not high, and dosage is big, and dust easily drifts about, and easily contaminated environment is used inconvenient.
Summary of the invention
The objective of the invention is to overcome the drug resistance problem of existing niclosamide, a kind of Synergistic composition that contains the niclosamide and the methaldehyde is provided.
Another object of the present invention provides a kind of application of above-mentioned composition.
A further object of the invention provides the composite suspending agent of a kind of snail-killing medicine niclosamide.
Purpose of the present invention can reach by following measure:
A kind of composition that contains the niclosamide and the methaldehyde, said composition is an active component with the niclosamide and the methaldehyde, and wherein the mass ratio of the niclosamide and the methaldehyde is 1～50: 1～10, is preferably 1～50: 1～5, more preferably 1～50: 1, most preferably be 25～30: 1～5.
Said composition is an active component with the niclosamide and the methaldehyde, is aided with that acceptable auxiliary can be made into acceptable forms on the various agricultural chemicals on the agricultural chemicals, as emulsion, water dispersible granules or suspending agent.
The above-mentioned composition that contains the niclosamide and the methaldehyde can be applicable to preparation control bilharziasis medicine aspect, particularly is applied to the killing oncomelania aspect.
The present invention also provides a kind of aqueous suspension agent that contains the niclosamide and the methaldehyde, and it comprises following component:
Niclosamide 1～50%, the methaldehyde 1～10%, wetting agent 1～5%, dispersant 1～20%, antifreezing agent 1～10%, preservative 0.1～1%, pH regulator agent 0.1～1%, defoamer 0.1～1%, thickener 0.1～2%, deionized water complements to 100%.Wherein the content of niclosamide is preferably 1～50%, and methaldehyde content is preferably 1～5%, most preferably is 1%.
In the above-mentioned aqueous suspension agent, wetting agent is lauryl sodium sulfate, draw back one or more the compound uses in powder, alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether, aliphatic acid polyethenoxy ether, the alkyl glycoside.
Dispersant is one or more the compound uses among sodium methylene bis-naphthalene sulfonate, lignosulfonates, polycarboxylate sodium, alkylphenol polyoxyethylene phosphate, the SOPA (speed pool) 270.
Antifreezing agent is ethylene glycol, glycerine, urea, sodium chloride.Preservative is selected Sodium Benzoate, card pine, formaldehyde for use.The PH conditioning agent is benzoic acid, glacial acetic acid, citric acid, hydrochloric acid.Defoamer is organic silicone, polyethers, butanols.Thickener xanthans, gelatin, gum Arabic, bentonite, aluminium-magnesium silicate.
Above-mentioned each component is mixed the back can make aqueous suspension agent by being ground to 1～10um.
Experiment finds that the composition of this killing oncomelania has obvious role in synergism, can effectively overcome the drug resistance problem of oncomelania.The niclosamide that the present invention makes and methaldehyde aqueous suspension agent control spectrum further enlarges, and molluscicidal effect is good, and not with an organic solvent, volatility is little, toxicity is low, safe for human and animal and environment; Nonflammable explosive, storing safety.Fine size, general particle diameter 2～5um, the suspensibility height, drug effect is than wetting powder height; Can mix with arbitrary proportion with water, easy to use, have significantly comprehensive and economic benefit.
Embodiment
Embodiment 1:15% niclosamide+1% methaldehyde suspending agent
By percentage to the quality, niclosamide 15%, the methaldehyde 1%, aliphatic acid polyethenoxy ether 2%, sodium methylene bis-naphthalene sulfonate salt 5%, calcium lignosulfonate 5%, ethylene glycol 5%, benzoic acid 0.3%, organic silicone defoamer 0.5%, card pine 0.2%, xanthans 0.3%, deionized water complements to 100%.Each component mixes with the high-shear emulsifying dispersion machine with this ratio, is ground to 2～3um through multistage sand mill, makes 15% niclosamide+1% methaldehyde SC.
Embodiment 2:25% niclosamide+1% methaldehyde suspending agent
By percentage to the quality, niclosamide 25%, the methaldehyde 1%, lauryl sodium sulfate 2%, sodium methylene bis-naphthalene sulfonate salt 5%, calcium lignosulfonate 5%, ethylene glycol 5%, benzoic acid 0.3%, organic silicone defoamer 0.5%, card pine 0.2%, xanthans 0.3%, deionized water complements to 100%.Each component mixes with the high-shear emulsifying dispersion machine with this ratio, is ground to 2～3um through multistage sand mill, makes 25% niclosamide+1% methaldehyde SC.
Embodiment 3:30% niclosamide+1% methaldehyde suspending agent
By percentage to the quality, niclosamide 30%, the methaldehyde 1%, alkylphenol polyoxyethylene 2%, the polycarboxylate sodium 2%, sodium methylene bis-naphthalene sulfonate salt 3%, ethylene glycol 5%, benzoic acid 1%, organic silicone defoamer 0.5%, card pine 0.2%, xanthans 0.2%, be ground to 2～3um through multistage sand mill, make 30% niclosamide+1% methaldehyde SC.
Embodiment 4:45% niclosamide+1% methaldehyde suspending agent
By percentage to the quality, niclosamide 45%, the methaldehyde 1%, fatty alcohol-polyoxyethylene ether 3%, the polycarboxylate sodium 2%, SOPA (speed pool) 2703%, ethylene glycol 5%, benzoic acid 1%, organic silicone defoamer 0.5%, card pine 0.2%, xanthans 0.1%, it is qualified to grind through multistage sand mill, makes 45% niclosamide+1% methaldehyde SC.
Embodiment 5: spend coefficient together
Pour into the 100ml soup in the beaker respectively and be settled to 200ml, every beaker put into 3 bags in the spiral shell bag that contains 30 oncomelanias, and the soup degree of depth exceeds spiral shell bag 2～3cm, establishes clear water (dechlorination water) contrast simultaneously.Immerse behind the soup at the spiral shell bag and respectively to take out 1 bag behind 24h, the 48h and 72h, after clear water is cleaned and dried, raises the back through 72h convalescence and identify that with hammering method oncomelania is dead and the number of surviving.
Calculate the LD50 value of obtaining various single agent and different assembly with Finny (1952) probit value analytical method, calculate co-toxicity coefficient (CTC) according to Sun method (1960) then, co-toxicity effect with composite dose of CTC value judgement, be summation action about CTC value 80-120, being significantly less than at 80 o'clock is antagonism, is synergistic effect greater than 120 o'clock obviously.
From the data of table 1 as can be seen, after the niclosamide and the methaldehyde are composite, comparatively obvious synergistic effect is arranged.
The 72h co-toxicity effect of table 1 niclosamide-methaldehyde
| Group number | Pesticide species | Virulence regression equation | Co-toxicity coefficient |
| 1. | Niclosamide | Y＝7.7977+3.4980X | / |
| 2. | The methaldehyde | Y＝5.3103+1.6816X | / |
| 3. | Niclosamide: the methaldehyde (10: 1) | Y＝8.8075+4.3354X | 129 |
| 4. | Niclosamide: the methaldehyde (25: 1) | Y＝7.9559+2.7934X | 187 |
| 5. | Niclosamide: the methaldehyde (50: 1) | Y＝7.8788+3.1312X | 134 |
| 6. | Niclosamide: the methaldehyde (1: 1) | Y＝6.2037+1.5598X | 151 |
Embodiment 6: oncomelania effect is extremely soaked in the laboratory
The niclosamide that the laboratory obtains with embodiment 2 in the time of 25 ℃ and the composite suspending agent of the methaldehyde are configured to active ingredient concentration 0.5,0.25,0.125,0.0625 and 0.0313 mg/litre and soak and killed spiral shell 24 hours, 48 hours and 72 hours, compare test with 50% niclosamide ethanolamine salt wetting powder and 1% methaldehyde suspending agent.The composite suspending agent active ingredient of niclosamide methaldehyde concentration 0.125 mg/litre immersion oncomelania becomes spiral shell to kill spiral shell in the time of 24 hours can reach 100%, LC50 (24 hours) is 0.0625 mg/litre, the LC50 of 50% niclosamide ethanolamine salt wetting powder (24 hours) is 0.1250 mg/litre, the LC50 of 1% methaldehyde suspending agent (24 hours) is greater than 0.5 mg/litre, and the composite suspending agent of niclosamide has molluscicidal effect (table 2) preferably.
Oncomelania effect is extremely soaked in table 2 laboratory
Embodiment 7: oncomelania effect is extremely soaked at the scene
Select the Nanjing Xixia District to carry out on-the-spot spraying molluscicide,, choose oncomelania density＞10/frame (0.1m by the baseline investigation
2) the oncomelania breeding place, be divided into 5 sub-districts, the about 100m in each sub-district
2, removing is higher than the weeds of 5cm and shifts out the test region in the sub-district.Wherein 3 sub-districts are experimental group, get embodiment 3 products respectively by 4.0,2.0 and 1.0g/m
2Spraying medicine, 1 sub-district is medicine control group 50% niclosamide ethanolamine salt wetting powder 2.0g/m
2, 1 sub-district is the blank group.Execute back 1,3 and 7d approximately, with checkerboard type methods of sampling investigation oncomelania, extract 10 frames in each test region and check plot respectively, catch whole oncomelanias in the frame, with the frame is that unit wraps with paper bag, record number, catches spiral shell number etc., returns indoor flushing with clean water, after 48h recovers to raise, identify oncomelania death toll and survival number with hammering method.The result shows that composite suspending agent has molluscicidal effect (table 3) preferably.
The on-the-spot sprinkling of table 3 killed the spiral shell result of the test
Above result shows the effective dose calculating by the composite suspending agent of niclosamide, and suspending agent is using 2.0g/m
2The time (effective dose 1.0g/m
2), can reach 50% bayluscid 2.0g (is effective dose 1.0g/m
2) molluscicidal effect, promptly consumption reduces by half, and can reach equal effect.
Claims (10)
1. composition that contains the niclosamide and the methaldehyde, it is characterized in that: said composition is an active component with the niclosamide and the methaldehyde, wherein the mass ratio of the niclosamide and the methaldehyde is 1～50: 1～10.
2. the composition that contains the niclosamide and the methaldehyde according to claim 1 is characterized in that: the mass ratio of the described niclosamide and the methaldehyde is 25～30: 1～5.
3. the composition that contains the niclosamide and the methaldehyde according to claim 1 is characterized in that: said composition is an active component with the niclosamide and the methaldehyde, is aided with on the agricultural chemicals acceptable auxiliary and makes emulsion, water dispersible granules or suspending agent.
4. the described application of composition aspect preparation control bilharziasis medicine that contains the niclosamide and the methaldehyde of claim 1.
5. the described application of composition aspect killing oncomelania that contains the niclosamide and the methaldehyde of claim 1.
6. aqueous suspension agent that contains the niclosamide and the methaldehyde is characterized in that: the component that comprises following mass content:
Niclosamide 1～50%, the methaldehyde 1～10%, wetting agent 1～5%, dispersant 1～20%, antifreezing agent 1～10%, preservative 0.1～1%, pH regulator agent 0.1～1%, defoamer 0.1～1%, thickener 0.1～2%, deionized water complements to 100%.
7. the aqueous suspension agent that contains the niclosamide and the methaldehyde according to claim 6 is characterized in that: the content of described niclosamide is 1～50%, and described methaldehyde content is 1～5%.
8. the aqueous suspension agent that contains the niclosamide and the methaldehyde according to claim 6 is characterized in that: described wetting agent is selected from lauryl sodium sulfate, draws back powder, in the alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether, aliphatic acid polyethenoxy ether, alkyl glycoside one or more.
9. the aqueous suspension agent that contains the niclosamide and the methaldehyde according to claim 6 is characterized in that: described dispersant is selected from one or more in sodium methylene bis-naphthalene sulfonate, lignosulfonates, polycarboxylate sodium, alkylphenol polyoxyethylene phosphate, the speed pool 270.
10. the aqueous suspension agent that contains the niclosamide and the methaldehyde according to claim 6 is characterized in that: described antifreezing agent is selected from one or more in ethylene glycol, glycerine, urea, the sodium chloride; Described preservative is selected one or more in Sodium Benzoate, card pine, the formaldehyde for use; Described pH regulator agent is selected from one or more in benzoic acid, glacial acetic acid, citric acid, the hydrochloric acid; Described defoamer is selected from one or more in organic silicone, polyethers, the butanols; Described thickener is selected from one or more in xanthans, gelatin, gum Arabic, bentonite, the aluminium-magnesium silicate.
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| CN 201110097790 CN102217598B (en) | 2011-04-18 | 2011-04-18 | Composition containing niclosamide and metaldehyde and compound suspension thereof |
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| CN 201110097790 CN102217598B (en) | 2011-04-18 | 2011-04-18 | Composition containing niclosamide and metaldehyde and compound suspension thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583513A (en) * | 2013-12-03 | 2014-02-19 | 四川省化学工业研究设计院 | Suspending agent of chlorosalicylamide as snail control drug and preparation method thereof |
| CN103766345A (en) * | 2014-01-26 | 2014-05-07 | 江苏艾津农化有限责任公司 | Mollusk killing bait formulation containing niclosamide and application thereof |
| CN103891720A (en) * | 2012-12-27 | 2014-07-02 | 陕西汤普森生物科技有限公司 | Luokuwei-containing compound gastropod-killing composition |
| CN104115832A (en) * | 2014-08-12 | 2014-10-29 | 广州农密生物科技有限公司白云分公司 | Efficient snail controlling suspending agent and preparation method thereof |
| CN104970019A (en) * | 2014-12-02 | 2015-10-14 | 铜陵县明晋生产力促进中心有限公司 | Preparation method of insecticide killing schistosoma and eggs |
| CN104970046A (en) * | 2014-12-02 | 2015-10-14 | 肖哲西 | Pesticide for killing mollusk pests |
| CN104982436A (en) * | 2015-07-15 | 2015-10-21 | 广西农战士高工效农业技术有限公司 | Insecticidal composition containing niclosamide and neonicotinoid pesticide |
| CN104996452A (en) * | 2015-07-03 | 2015-10-28 | 天峨县科学技术情报研究所 | Pesticide composition containing niclosamide ethanolamine and thiacloprid |
| CN107006459A (en) * | 2017-05-19 | 2017-08-04 | 广东农密生物科技有限公司 | A kind of mollusk control water dispersible granules and preparation method thereof |
| CN112961527A (en) * | 2019-12-13 | 2021-06-15 | 徐州诺特化工有限公司 | Processing technology of metaldehyde and melamine modified urea-formaldehyde glue compounded ship body protective agent |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107027783A (en) * | 2017-05-26 | 2017-08-11 | 山东省农药科学研究院 | A kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103891720A (en) * | 2012-12-27 | 2014-07-02 | 陕西汤普森生物科技有限公司 | Luokuwei-containing compound gastropod-killing composition |
| CN103891720B (en) * | 2012-12-27 | 2016-02-17 | 陕西汤普森生物科技有限公司 | A kind ofly kill spiral shell composition containing the composite of the withered prestige of spiral shell |
| CN103583513A (en) * | 2013-12-03 | 2014-02-19 | 四川省化学工业研究设计院 | Suspending agent of chlorosalicylamide as snail control drug and preparation method thereof |
| CN103766345B (en) * | 2014-01-26 | 2015-11-18 | 江苏艾津农化有限责任公司 | A kind of containing niclosamide kill mollusk bait formulation and application thereof |
| CN103766345A (en) * | 2014-01-26 | 2014-05-07 | 江苏艾津农化有限责任公司 | Mollusk killing bait formulation containing niclosamide and application thereof |
| CN104115832A (en) * | 2014-08-12 | 2014-10-29 | 广州农密生物科技有限公司白云分公司 | Efficient snail controlling suspending agent and preparation method thereof |
| CN104970046A (en) * | 2014-12-02 | 2015-10-14 | 肖哲西 | Pesticide for killing mollusk pests |
| CN104970019A (en) * | 2014-12-02 | 2015-10-14 | 铜陵县明晋生产力促进中心有限公司 | Preparation method of insecticide killing schistosoma and eggs |
| CN104996452A (en) * | 2015-07-03 | 2015-10-28 | 天峨县科学技术情报研究所 | Pesticide composition containing niclosamide ethanolamine and thiacloprid |
| CN104982436A (en) * | 2015-07-15 | 2015-10-21 | 广西农战士高工效农业技术有限公司 | Insecticidal composition containing niclosamide and neonicotinoid pesticide |
| CN104982436B (en) * | 2015-07-15 | 2017-12-01 | 广西农战士高工效农业技术有限公司 | A kind of Pesticidal combination containing niclosamide and anabasine pesticide |
| CN107006459A (en) * | 2017-05-19 | 2017-08-04 | 广东农密生物科技有限公司 | A kind of mollusk control water dispersible granules and preparation method thereof |
| CN112961527A (en) * | 2019-12-13 | 2021-06-15 | 徐州诺特化工有限公司 | Processing technology of metaldehyde and melamine modified urea-formaldehyde glue compounded ship body protective agent |
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Denomination of invention: Composition containing niclosamide and metaldehyde and compound suspension thereof Effective date of registration: 20150323 Granted publication date: 20130828 Pledgee: Bank of Beijing, Limited by Share Ltd, Nanjing branch Pledgor: Jiangsu Aijin Agrochemical Co., Ltd. Registration number: 2015320000002 |
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Denomination of invention: Composition containing niclosamide and metaldehyde and compound suspension thereof Effective date of registration: 20190424 Granted publication date: 20130828 Pledgee: Hongwu Branch of Nanjing Bank Co., Ltd. Pledgor: Jiangsu Aijin Agrochemical Co., Ltd. Registration number: 2019320000196 |
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Address after: 65 shuangxiang Road, Xiongzhou street, Liuhe District, Nanjing City, Jiangsu Province, 210000 Patentee after: Jiangsu Aijin crop Technology Group Co., Ltd Address before: 211511, No. 58, Lane No. 2, Hongshan Fine Chemical Industrial Park, Liuhe District, Jiangsu, Nanjing Patentee before: JIANGSU ESSENCE AGROCHEMICAL Co.,Ltd. |
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