CN102217589A - Perfusion preservation device for liver - Google Patents

Abstract

The invention relates to a liver perfusion preservation device, in particular to a liver perfusion preservation device. A liver perfusion preservation device, comprising a water bath box for storing the liver, the water bath box is perfused with a preservation solution, characterized in that the water bath box is respectively provided with a bile duct infusion tube connected to the bile duct, and a liver tube connected to the hepatic artery. The arterial infusion tube and the portal vein infusion tube connected with the portal vein, the ends of the bile duct infusion tube, the hepatic artery infusion tube, and the portal vein infusion tube are all connected to the liquid storage tank through pipelines, and the other end of the liquid storage tank is connected to the pressure-adjustable The hydraulic pump is connected, and the hydraulic pump is directly connected with the water bath box through a pipeline. The invention has the characteristics of being specially used for liver perfusion preservation, simple structure, convenient use, long storage time, ideal perfusion effect and the like.

Description

Liver Perfusion Preservation Device

technical field

The invention relates to a liver perfusion preservation device, in particular to a liver perfusion preservation device.

Background technique

As we all know, according to the report of the World Health Organization, there are currently about 350 million people in the world who are carriers of hepatitis B virus, about 45 million people die of liver cirrhosis every year, and 60 million people die of primary liver cancer. my country is the country with the most serious hepatitis B infection in the world, and about 140 million people are carriers of hepatitis B virus, accounting for one-third of the world. Among them, 30 million are chronic hepatitis, liver cirrhosis, and primary liver cancer, and as many as 300,000 people die of chronic liver disease every year. Zhejiang Province has always been a major province of liver disease, with an average of one in 10 people infected with hepatitis B virus. The prevailing alcohol culture and overloaded work, like a catalyst, promote the rapid progression of hepatitis to fulminant liver failure or liver cirrhosis, liver cancer. The province has lost a large number of economic elites and technological elites, and the average level of the province's labor force has also dropped significantly. Liver transplantation has become recognized as the most effective treatment for end-stage liver disease. Unfortunately, China's cultural traditions make it difficult to pass the brain death law in our country and it is very difficult to obtain cadaveric organs. The severe shortage of donors makes most recipients wait death. Therefore, living donor liver transplantation has achieved rapid development in several major domestic liver transplantation centers in recent years.

Therefore, how to make the isolated liver survive during the period from harvesting to clinical application has become the subject of current research. In the prior art, there are many methods for liver preservation, but recent research results show that the in vitro perfusion method has a better preservation effect, and the isolated liver can survive for 2-3 days. If a liver preservation and perfusion device is made according to the results of this study, time can be gained for long-distance acquisition of human liver. But at present, there is no such device dedicated to liver preservation and perfusion.

Contents of the invention

The present invention mainly aims at the above-mentioned technical problems existing in the prior art, and provides a liver perfusion preservation device which is specially used for liver perfusion preservation, has a simple structure, is convenient to use, and has a long storage time.

The above-mentioned technical problems of the present invention are mainly solved by the following technical solutions: a liver perfusion storage device, including a water bath box for storing the liver, the water bath box is perfused with a preservation solution, and it is characterized in that the water bath box A bile duct infusion tube connected to the bile duct, a hepatic artery infusion tube connected to the hepatic artery, and a portal vein infusion tube connected to the portal vein are respectively provided. The liquid tank is connected, and the other end of the liquid storage tank is connected with a pressure-adjustable hydraulic pump, and the hydraulic pump is directly connected with the water bath box through a pipeline. The bile duct infusion tube, hepatic artery infusion tube, and portal vein infusion tube are respectively connected to the bile duct, hepatic artery, and portal vein on the liver and perfused by a hydraulic pump. The hydraulic pump is directly connected to the water bath tank through another pipeline to continuously supply the water bath tank. pressure to ensure the circulation of the preservation solution in the water bath.

Preferably, the hepatic artery infusion tube and the portal vein infusion tube are respectively provided with a one-way hepatic artery infusion valve and a one-way portal vein infusion valve. In order to ensure one-way perfusion of the hepatic artery and portal vein, a one-way hepatic artery infusion valve and a one-way portal vein infusion valve are respectively set on the hepatic artery infusion tube and the portal vein infusion tube. Venous vascular output.

As a preference, the water bath box is connected with the oxygen pump through the air pipe. The oxygen pump can be used to continuously supply oxygen in the water bath to prolong the storage time.

As a preference, the water bath box is provided with a temperature controller, and the temperature controller is connected with the control chip provided in the water bath box. The water bath box is equipped with a temperature controller, which can control the temperature in the water bath box at about 15° to achieve the best preservation effect. It is easy to use and has strong practicability.

As a preference, the top of the water bath is provided with an upper cover for perfusing the preservation solution. The upper cover is a reversible opening structure. When the preservation solution needs to be filled, the upper cover can be opened, and the preservation solution can be directly filled from above.

As a preference, the lower part of the water bath box is provided with a drain port for replacing the storage solution. The drain port is used for replacing the storage solution, and it is more convenient and quick to drain the storage solution out of the water bath.

Therefore, the present invention has the characteristics of being specially used for liver perfusion preservation, simple structure, convenient use, long storage time, ideal perfusion effect and the like.

Description of drawings

Accompanying drawing 1 is a kind of structural representation of the present invention.

Detailed ways

The technical solutions of the present invention will be further specifically described below through the embodiments and in conjunction with the accompanying drawings.

Example 1:

As shown in Figure 1 of the description, a liver perfusion preservation device includes a water bath box 1 for storing the liver 3, the water bath box is filled with a preservation solution 2, and the water bath box is respectively provided with a bile duct infusion tube 4 connected to the bile duct, The hepatic artery infusion tube 5 connected with the hepatic artery and the portal vein infusion tube 6 connected with the portal vein, the ends of the bile duct infusion tube, the hepatic artery infusion tube, and the portal vein infusion tube are all connected to the liquid storage tank 7 through pipelines, and the other end of the liquid storage tank is connected to the available The pressure regulating hydraulic pump 12 is connected, and the hydraulic pump is directly connected with the water bath tank through a pipeline. The hepatic artery infusion tube and the portal vein infusion tube are respectively provided with a one-way hepatic artery infusion valve 8 and a one-way portal vein infusion valve 9 . The water bath box is connected with the oxygen pump 10 through the gas delivery pipe. The water bath box is provided with a temperature controller 11, and the temperature controller is connected with the control chip arranged in the water bath box. The top of the water bath box is provided with a loam cake 13 for filling the preservation solution. The lower part of the water bath box is provided with a drain port 14 for replacing the storage solution.

When using the present invention for preservation and perfusion, first open the upper cover 13, inject the preservation solution 2 from above, put the liver 3 into the preservation solution, and then communicate with the bile duct on the liver through the bile duct infusion tube, hepatic artery infusion tube and portal vein infusion tube respectively. , hepatic artery, and portal vein are connected and perfused by a hydraulic pump. The hydraulic pump is directly connected to the water bath box through another pipeline to continuously supply pressure to the water bath box to ensure the circulation of the preservation solution in the water bath box. Through the temperature controller set on the water bath box, the temperature in the water bath box is controlled at 15° to achieve the most ideal preservation effect. The oxygen pump is used to continuously supply oxygen in the water bath to prolong the storage time. In order to ensure one-way perfusion of the hepatic artery and portal vein, a one-way hepatic artery infusion valve and a one-way portal vein infusion valve are respectively set on the hepatic artery infusion tube and the portal vein infusion tube. Venous blood vessel 15 outputs.

It should be understood that this embodiment is only used to illustrate the present invention and is not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

Claims (6)

1. A liver perfusion preservation device, comprising a water bath box (1) for storing the liver (3), the water bath box is perfused with a preservation solution (2), characterized in that the water bath box is respectively provided with bile ducts The bile duct infusion tube (4), the hepatic artery infusion tube (5) connected with the hepatic artery, and the portal vein infusion tube (6) connected with the portal vein, the ends of the bile duct infusion tube, hepatic artery infusion tube, and portal vein infusion tube all pass through The pipeline is connected with the liquid storage tank (7), and the other end of the liquid storage tank is connected with the pressure-adjustable hydraulic pump (12), and the hydraulic pump is directly connected with the water bath tank through the pipeline. 2. The liver perfusion preservation device according to claim 1, characterized in that the hepatic artery infusion tube and the portal vein infusion tube are respectively provided with a one-way hepatic artery infusion valve (8) and a one-way portal vein infusion valve (9) . 3. The liver perfusion preservation device according to claim 1 or 2, characterized in that the water bath is connected to the oxygen pump (10) through an air tube. 4. The liver perfusion preservation device according to claim 1 or 2, characterized in that the water bath is provided with a temperature controller (11), and the temperature controller is connected to a control chip installed in the water bath . 5. The liver perfusion preservation device according to claim 1 or 2, characterized in that the top of the water bath is provided with an upper cover (13) for perfusion preservation solution. 6. The liver perfusion preservation device according to claim 1 or 2, characterized in that the lower part of the water bath is provided with a drain port (14) for replacing the preservation solution.

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