CN101983688B - Drug for treating diabetes and preparation method thereof - Google Patents
Drug for treating diabetes and preparation method thereof Download PDFInfo
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- CN101983688B CN101983688B CN2010102637317A CN201010263731A CN101983688B CN 101983688 B CN101983688 B CN 101983688B CN 2010102637317 A CN2010102637317 A CN 2010102637317A CN 201010263731 A CN201010263731 A CN 201010263731A CN 101983688 B CN101983688 B CN 101983688B
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Abstract
The invention discloses a drug for treating diabetes, which is characterized by being mainly prepared from the following raw materials by weight: 1-20 parts of roses, 1-20 parts of seville orange flowers, 1-20 parts of the root of straight ladybell, 1-20 parts of radix polygonati officinalis, 1-20 parts of radix ophiopogonis, 1-20 parts of shizandra, 1-20 parts of radix rehmanniae, 1-20 parts of gypsum, 1-20 parts of rhizoma anemarrhenae, 1-20 parts of pine pollen, 1-20 parts of dark plum, 1-20 parts of pulp of cornus, 1-20 parts of mantis egg-case, 1-20 parts of rhizoma coptidis, 1-20 parts of raw radix astragali and 1-20 parts of edible alcohol with content being more than 95%. The drug can be absorbed by the spleens and stomachs internally or absorbed by skins externally or absorbed internally and externally. The drug has reasonable components, simple compatibility and confirmed curative effect and treats both principal and secondary aspects of the diseases. The invention also provides a preparation method of the drug.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment diabetes of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Diabetes cause by the h and E factor interaction, to continue a kind of chronic general metabolic disease of hyperglycemia for its basic biochemical character.Mainly be since in the body insulin secretion definitely lack or owing to health increases the insulin relative deficiency that causes to the demand of insulin; Thereby cause with the carbohydrate metabolism disturbance is that a kind of syndrome
of main sugar
protein
fat metabolic disturbance can cause the complication
of histoorgans such as neural
blood vessel
kidney of eye
to cause the infringement of health multisystem along with the course of disease prolongs
; Be the incretion metabolism disease
of serious harm human body clinical be outstanding feature with the hyperglycemia, common sympton has polydipsia, polyuria, polyphagia and becomes thin etc.
Chinese patent CN200710010774.2 discloses a kind of Chinese medicine of treating diabetes, is to decoct formulated by Fructus Gardeniae, Herba Artemisiae Scopariae, Gypsum Fibrosum, Radix Bupleuri, Radix Gentianae, Herba Swertiae Mileensis, Fructus Schisandrae Chinensis, the Radix Astragali, Fructus Corni, Flos Lonicerae, Herba mesonae chinensis, Radix Puerariae, Radix Ginseng, Cordyceps.Chinese patent CN200710013828.0 discloses a kind of Chinese medicine preparation of treating diabetes, is processed by following materials of weight proportions: Stichopus japonicus, Radix Salviae Miltiorrhizae, Fructus Momordicae charantiae, Hirudo, xylitol.Its preparation method is that fresh Stichopus japonicus, Radix Salviae Miltiorrhizae, Fructus Momordicae charantiae, Hirudo are put into the freeze dryer lyophilizing, clays into power then, again with the xylitol proportional mixing.Chinese patent CN200410048002.4 discloses a kind of be used to the treat Chinese medicine preparation of diabetes and the method for this medication preparation thereof, is made up of the Rhizoma Anemarrhenae, Rhizoma Atractylodis, Rhizoma Coptidis, Pollen Typhae, Herba Euphorbiae Humifusae, is mainly used in treatment diabetes and concurrent syndrome thereof.
The Chinese medicine product of above-mentioned treatment diabetes is too much paid attention to regulating, and has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable; And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to be mostly powder, the decoction that boils or pill than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists; A kind of reasonable recipe is provided; Compatibility is simplified, the medicine of the treatment diabetes of determined curative effect, treating both the principal and secondary aspects of a disease, is main to control, and controls to support to combine; And this medicine can take orally through taste absorb again can external through skin absorbs, can also oral administration and externally used dual mode composite absorbent.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is following:
A kind of medicine of treating diabetes is characterized in that it mainly is to be processed by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Radix Adenophorae (Radix Glehniae), 1 ~ 20 part of Rhizoma Polygonati Odorati; 1 ~ 20 part of Radix Ophiopogonis, 1 ~ 20 part of Fructus Schisandrae Chinensis, 1 ~ 20 part in the Radix Rehmanniae, 1 ~ 20 part of Gypsum Fibrosum; 1 ~ 20 part of the Rhizoma Anemarrhenae, 1 ~ 20 part of Pollen Pini, 1 ~ 20 part of Fructus Mume, 1 ~ 20 part of Fructus Corni; 1 ~ 20 part of Ootheca Mantidis, 1 ~ 20 part of Rhizoma Coptidis, 1 ~ 20 part of Radix Astragali, content are 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Radix Adenophorae (Radix Glehniae), 15 ~ 20 parts of Rhizoma Polygonati Odorati; 15 ~ 20 parts of Radix Ophiopogonis, 15 ~ 20 parts of Fructus Schisandrae Chinensis, 15 ~ 20 parts in the Radix Rehmanniae, 15 ~ 20 parts of Gypsum Fibrosum; 15 ~ 20 parts of the Rhizoma Anemarrhenaes, 15 ~ 20 parts of Pollen Pinis, 15 ~ 20 parts of Fructus Mumes, 15 ~ 20 parts of Fructus Corni; 15 ~ 20 parts of Ootheca Mantidiss, 15 ~ 20 parts of Rhizoma Coptidis, 15 ~ 20 parts of Radix Astragali, content are 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Adenophorae (Radix Glehniae), Rhizoma Polygonati Odorati, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Rehmanniae, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Pollen Pini, Fructus Mume, Fructus Corni, Ootheca Mantidis, Rhizoma Coptidis and the Radix Astragali of said weight proportion; According to the conventional method for distilling of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds said weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrating sterilization, fill according to quantity must be treated the medicine of diabetes.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional method for distilling of said Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to Diabetes mellitus; Select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Adenophorae (Radix Glehniae), Rhizoma Polygonati Odorati, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Rehmanniae, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Pollen Pini, Fructus Mume, Fructus Corni, Ootheca Mantidis, Rhizoma Coptidis, Radix Astragali for use; With being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction, process to contain pure Chinese medicine extraction liquid.Employing is main to control, and control the bonded method of supporting, but not only also external of oral administration of the medicine of processing is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment diabetes of determined curative effect, treating both the principal and secondary aspects of a disease.
Radix Adenophorae (Radix Glehniae) meridian distribution of property and flavor, sweet, be slightly cold clearing lung and nourishing yin, reinforcing stomach reg fluid.Radix Ophiopogonis meridian distribution of property and flavor, sweet, little hardship is slightly cold, nourishing YIN and moistening the lung, reinforcing stomach reg fluid, relieving restlessness clears away heart-fire.Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Radix Astragali invigorating QI to consolidate the body surface resistance, hidroschesis detoxification, granulation promoting, diuresis, detumescent.Radix Rehmanniae nourishing YIN and clearing away heat; Removing heat from blood is enriched blood.Rhizoma Anemarrhenae nourishing YIN to lower pathogenic fire is moisturized laxation.Gypsum Fibrosum heat clearing away cooling, promoting the production of body fluid to quench thirst.Pollen Pini, Fructus Mume convergence are promoted the production of body fluid; Fructus Corni liver and kidney tonifying, essence astringing and desertion stemming; Ootheca Mantidis controlling nocturnal emission with astringent drugs reducing urination, reinforcing the kidney and supporting YANG.The Rhizoma Coptidis pathogenic fire purging, dampness, detoxifcation.
Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Astragali, the Radix Rehmanniae, the Rhizoma Anemarrhenae, Gypsum Fibrosum, Pollen Pini, Rhizoma Coptidis, Rhizoma Polygonati Odorati clearing away heat and strengthening QI to produce body fluid in the medicine of the present invention; Get Fructus Corni, Fructus Mume, Ootheca Mantidis again, sour and astringent convergence, and sour and sweet drugs can transforme into YIN and play the clear merit of cloudy re-heat, and medicine all is that quality makes moist, promoting the production of body fluid liquid are mended and not dry, grow and oiliness, keep Zhong Huayin, and too not cold and cool, do not hinder elevator, and be most suitable.According to clinical report and drug research, SHENGMAI SAN and Rhizoma Polygonati Odorati, the Radix Rehmanniae, Rhizoma Coptidis etc. all have the blood sugar lowering effect." augmented injection Bencao Congxin " record: " the sweet temperature of Pupa bombycis can be rushed down bladder fire mutually, draws on the clearing heat in QI system tide in mouth, only quenches one's thirst ".Diabetes there is curative effect preferably.And medicated diet brings out the best in each other with executing especially.Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two to be transferred, and the strength of eliminating turbid pathogen with aromatics, be amusing appetizing, regulating QI to relieve pain strengthens.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs.
Medicine of the present invention can also be smeared by whole body except for oral administration.Adopt oral administration and externally usedly, drug effect is more remarkable.
Medicine of the present invention is through clinical 70 routine patients' clinical verification, and curing number is 42 examples, and significant figure is 24 examples, and invalid number is 4 examples, and total effective rate reaches 94.3%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, to enumerate model case following at present:
Case 1: certain man, 61 years old, hospital diagnosis was not diabetes before the medication, show as: bulimia, thirsty frequent micturition, body weight alleviate to 70 kilograms from 78.5 kilograms unusually.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above disease was alleviated in 10 days, and diet desire and body weight begin to recover normal after 30 days.Pay a return visit weight recovery to 75 kilogram after 6 months, life is normal.
Case 2: certain woman, 57 years old, hospital diagnosis was not diabetes before the medication, shows as: feel hungry often with thirsty, urinate increase, body weight alleviates to 66 kilograms from 72 kilograms unusually.External medicine of the present invention is smeared whole body, and every day 2 times, each 10 milliliters, above disease was alleviated in 7 days, and diet desire and body weight begin to recover normal after 30 days.Pay a return visit weight recovery to 70 kilogram after 8 months, life is normal.
Case 3: certain man, 47 years old, hospital diagnosis was not diabetes before the medication, show as: eat meal every day five or six times, non-staple foodstuff can't satisfy appetite also than normal person showed increased, urinate increase, body weight alleviates to 69 kilograms from 78 kilograms unusually.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body, every day 2 times, each 10 milliliters.Oral and external was greatly alleviated after 6 days.Use continuously and recover normal after 30 days gradually.Pay a return visit weight recovery to 75 kilogram after 9 months, life is normal.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of Radix Adenophorae (Radix Glehniae), 16 parts of Rhizoma Polygonati Odorati, 16 parts of Radix Ophiopogonis; 16 parts of Fructus Schisandrae Chinensis, 16 parts in the Radix Rehmanniae, 16 parts of Gypsum Fibrosum, 16 parts of the Rhizoma Anemarrhenaes; 16 parts of Pollen Pinis, 16 parts of Fructus Mumes, 16 parts of Fructus Corni, 16 parts of Ootheca Mantidiss; 16 parts of Rhizoma Coptidis, 16 parts of Radix Astragali adopt the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and are subsequent use.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the treatment diabetes of oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, 19 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts of Radix Adenophorae (Radix Glehniae), 17 parts of Rhizoma Polygonati Odorati; 17 parts of Radix Ophiopogonis, 18 parts of Fructus Schisandrae Chinensis, 18 parts in the Radix Rehmanniae, 17 parts of Gypsum Fibrosum; 17 parts of the Rhizoma Anemarrhenaes, 18 parts of Pollen Pinis, 18 parts of Fructus Mumes, 18 parts of Fructus Corni; 18 parts of Ootheca Mantidiss, 17 parts of Rhizoma Coptidis, 18 parts of Radix Astragali, content are 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, 20 parts of CitrusaurantiumL.Var.amara Engl.s, 20 parts of Radix Adenophorae (Radix Glehniae), 20 parts of Rhizoma Polygonati Odorati; 19 parts of Radix Ophiopogonis, 18 parts of Fructus Schisandrae Chinensis, 19 parts in the Radix Rehmanniae, 18 parts of Gypsum Fibrosum; 18 parts of the Rhizoma Anemarrhenaes, 19 parts of Pollen Pinis, 19 parts of Fructus Mumes, 19 parts of Fructus Corni; 19 parts of Ootheca Mantidiss, 18 parts of Rhizoma Coptidis, 20 parts of Radix Astragali, content are 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 15 parts of Flos Rosae Rugosaes, 16 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts of Radix Adenophorae (Radix Glehniae), 19 parts of Rhizoma Polygonati Odorati; 18 parts of Radix Ophiopogonis, 18 parts of Fructus Schisandrae Chinensis, 16 parts in the Radix Rehmanniae, 16 parts of Gypsum Fibrosum; 19 parts of the Rhizoma Anemarrhenaes, 8 parts of Pollen Pinis, 16 parts of Fructus Mumes, 17 parts of Fructus Corni; 18 parts of Ootheca Mantidiss, 19 parts of Rhizoma Coptidis, 19 parts of Radix Astragali, content are 16 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts of Radix Adenophorae (Radix Glehniae), 16 parts of Rhizoma Polygonati Odorati; 17 parts of Radix Ophiopogonis, 19 parts of Fructus Schisandrae Chinensis, 18 parts in the Radix Rehmanniae, 19 parts of Gypsum Fibrosum; 16 parts of the Rhizoma Anemarrhenaes, 17 parts of Pollen Pinis, 16 parts of Fructus Mumes, 19 parts of Fructus Corni; 20 parts of Ootheca Mantidiss, 19 parts of Rhizoma Coptidis, 16 parts of Radix Astragali, content are 19 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of Radix Adenophorae (Radix Glehniae), 17 parts of Rhizoma Polygonati Odorati; 18 parts of Radix Ophiopogonis, 19 parts of Fructus Schisandrae Chinensis, 17 parts in the Radix Rehmanniae, 16 parts of Gypsum Fibrosum; 19 parts of the Rhizoma Anemarrhenaes, 17 parts of Pollen Pinis, 18 parts of Fructus Mumes, 20 parts of Fructus Corni; 19 parts of Ootheca Mantidiss, 17 parts of Rhizoma Coptidis, 18 parts of Radix Astragali, content are 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (1)
1. medicine of treating diabetes is characterized in that being processed by following method:
(1) takes by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of Radix Adenophorae (Radix Glehniae), 16 parts of Rhizoma Polygonati Odorati, 16 parts of Radix Ophiopogonis; 16 parts of Fructus Schisandrae Chinensis, 16 parts in the Radix Rehmanniae, 16 parts of Gypsum Fibrosum, 16 parts of the Rhizoma Anemarrhenaes; 16 parts of Pollen Pinis, 16 parts of Fructus Mumes, 16 parts of Fructus Corni, 16 parts of Ootheca Mantidiss; 16 parts of Rhizoma Coptidis, 16 parts of Radix Astragali adopt the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and are subsequent use;
(2) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use;
(3) above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the treatment diabetes of for oral administration or external carries out fill under aseptic condition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102637317A CN101983688B (en) | 2010-08-26 | 2010-08-26 | Drug for treating diabetes and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102637317A CN101983688B (en) | 2010-08-26 | 2010-08-26 | Drug for treating diabetes and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101983688A CN101983688A (en) | 2011-03-09 |
| CN101983688B true CN101983688B (en) | 2012-07-25 |
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| CN2010102637317A Expired - Fee Related CN101983688B (en) | 2010-08-26 | 2010-08-26 | Drug for treating diabetes and preparation method thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115530373B (en) * | 2022-10-11 | 2023-08-15 | 重庆深山生物科技有限公司 | Health food suitable for diabetics and preparation method thereof |
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2010
- 2010-08-26 CN CN2010102637317A patent/CN101983688B/en not_active Expired - Fee Related
Non-Patent Citations (7)
| Title |
|---|
| 南京中医药大学.玫瑰花 |
| 南京中医药大学.玫瑰花;玳玳花.《中药大辞典》.上海科学技术出版社,2006,1745-1748,2098. * |
| 张兆旺，等.中药合剂（含口服液） |
| 张兆旺,等.中药合剂(含口服液)渗透促进剂.《中药药剂学》.中国中医药出版社,2002,103-105,185-187. * |
| 渗透促进剂.《中药药剂学》.中国中医药出版社,2002,103-105，185-187. |
| 玳玳花.《中药大辞典》.上海科学技术出版社,2006,1745-1748，2098. |
| 高尚社.生脉胜甘汤.《常见疑难病中西医诊治精要》.民族出版社,2000,144. * |
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