CN101971921A - Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof - Google Patents
Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof Download PDFInfo
- Publication number
- CN101971921A CN101971921A CN2010105410358A CN201010541035A CN101971921A CN 101971921 A CN101971921 A CN 101971921A CN 2010105410358 A CN2010105410358 A CN 2010105410358A CN 201010541035 A CN201010541035 A CN 201010541035A CN 101971921 A CN101971921 A CN 101971921A
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- Prior art keywords
- zinc
- lactobacillus
- deactivation
- rich
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims abstract description 148
- 239000011701 zinc Substances 0.000 title claims abstract description 147
- 229910052725 zinc Inorganic materials 0.000 title claims abstract description 147
- 241000186660 Lactobacillus Species 0.000 title claims abstract description 39
- 229940039696 lactobacillus Drugs 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 39
- 239000003795 chemical substances by application Substances 0.000 title abstract description 8
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 82
- 239000011787 zinc oxide Substances 0.000 claims abstract description 41
- 238000000855 fermentation Methods 0.000 claims abstract description 22
- 230000004151 fermentation Effects 0.000 claims abstract description 22
- 239000001963 growth medium Substances 0.000 claims abstract description 15
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000009849 deactivation Effects 0.000 claims description 61
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 28
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 21
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 21
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 21
- 241000186869 Lactobacillus salivarius Species 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 14
- 239000000377 silicon dioxide Substances 0.000 claims description 14
- 240000008042 Zea mays Species 0.000 claims description 11
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 claims description 11
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 11
- 235000009973 maize Nutrition 0.000 claims description 11
- 235000012054 meals Nutrition 0.000 claims description 11
- 150000003752 zinc compounds Chemical class 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 10
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 8
- 239000003223 protective agent Substances 0.000 claims description 8
- 238000001179 sorption measurement Methods 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 235000015097 nutrients Nutrition 0.000 claims description 6
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 6
- 229960001763 zinc sulfate Drugs 0.000 claims description 6
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 claims description 5
- 229920002261 Corn starch Polymers 0.000 claims description 5
- 239000008120 corn starch Substances 0.000 claims description 5
- 229940099112 cornstarch Drugs 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 239000011592 zinc chloride Substances 0.000 claims description 5
- 235000005074 zinc chloride Nutrition 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 235000020183 skimmed milk Nutrition 0.000 claims description 3
- 150000003751 zinc Chemical class 0.000 claims description 3
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims description 2
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims description 2
- 241000194035 Lactococcus lactis Species 0.000 claims description 2
- 235000014897 Streptococcus lactis Nutrition 0.000 claims description 2
- 229940004120 bifidobacterium infantis Drugs 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 abstract description 13
- 241001465754 Metazoa Species 0.000 abstract description 13
- 244000144977 poultry Species 0.000 abstract description 6
- 239000003674 animal food additive Substances 0.000 abstract description 2
- 231100000572 poisoning Toxicity 0.000 abstract description 2
- 230000000607 poisoning effect Effects 0.000 abstract description 2
- 241000282887 Suidae Species 0.000 abstract 2
- 244000144972 livestock Species 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000003912 environmental pollution Methods 0.000 abstract 1
- 210000003608 fece Anatomy 0.000 abstract 1
- 208000028774 intestinal disease Diseases 0.000 abstract 1
- 239000010871 livestock manure Substances 0.000 abstract 1
- 235000016804 zinc Nutrition 0.000 description 120
- 238000012360 testing method Methods 0.000 description 26
- 235000018291 probiotics Nutrition 0.000 description 24
- 239000006041 probiotic Substances 0.000 description 22
- 241000282898 Sus scrofa Species 0.000 description 19
- 230000002354 daily effect Effects 0.000 description 13
- 238000007792 addition Methods 0.000 description 12
- 230000003647 oxidation Effects 0.000 description 12
- 238000007254 oxidation reaction Methods 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 235000014590 basal diet Nutrition 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 8
- 230000002265 prevention Effects 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 239000002609 medium Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 241000186000 Bifidobacterium Species 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 4
- 235000021050 feed intake Nutrition 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 229910052720 vanadium Inorganic materials 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000010828 animal waste Substances 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- 244000144974 aquaculture Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000000536 complexating effect Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000002942 anti-growth Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940038879 chelated zinc Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000009374 poultry farming Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
- RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical group [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Fodder In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN2010105410358A CN101971921B (en) | 2010-11-12 | 2010-11-12 | Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof |
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CN2010105410358A CN101971921B (en) | 2010-11-12 | 2010-11-12 | Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof |
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CN101971921A true CN101971921A (en) | 2011-02-16 |
CN101971921B CN101971921B (en) | 2013-05-08 |
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Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103146611A (en) * | 2013-03-12 | 2013-06-12 | 通威股份有限公司 | Preparation method for composite-type lactobacillus microecological preparation |
CN103211143A (en) * | 2013-03-26 | 2013-07-24 | 胡文锋 | Inactivated lactobacillus effervescent tablets and preparation method thereof |
CN103283973A (en) * | 2013-03-20 | 2013-09-11 | 广州格拉姆生物科技有限公司 | A method for producing a probiotic agent of live Lactobacillus acidophilus |
CN103602707A (en) * | 2013-04-25 | 2014-02-26 | 胡文锋 | Bio-synthesis method of nano zinc oxide by utilizing lactic acid bacteria and nano zinc oxide composite feed addictive |
CN103750341A (en) * | 2014-01-13 | 2014-04-30 | 苏州万生源生物科技有限公司 | Inactivated bacteroid micro-ecological preparation and preparation method thereof |
CN103977025A (en) * | 2014-04-30 | 2014-08-13 | 南昌大学 | Bacteriostatic composition of lactobacillus plantarum fermentation liquid and nano zinc oxide |
CN103977032A (en) * | 2014-04-30 | 2014-08-13 | 南昌大学 | Novel bacteriostatic composition containing bifidobacteria fermented liquid |
CN104357360A (en) * | 2014-11-14 | 2015-02-18 | 湖南农业大学 | Pediococcus acidilactici liquid raw material fermentation medium for feed and fermentation method |
CN104721237A (en) * | 2013-12-22 | 2015-06-24 | 青岛碧水蓝天生物技术有限公司 | Lactobacillus microecological preparation used in intestinal tract disease treatment drugs |
CN104957373A (en) * | 2015-06-10 | 2015-10-07 | 山东省农业科学院畜牧兽医研究所 | Method for reducing heavy metal emission in livestock and poultry manure |
CN108841763A (en) * | 2018-07-20 | 2018-11-20 | 江苏微康生物科技有限公司 | A kind of preparation method of zinc dense plants lactobacillus additive |
CN109563473A (en) * | 2016-08-09 | 2019-04-02 | Cj第制糖株式会社 | Lactobacillus salivarius CJLS1511, the method added composition containing the animal feed of the bacterium or dead cell and produce dead cell |
CN109984260A (en) * | 2019-04-12 | 2019-07-09 | 生物源生物技术(深圳)股份有限公司 | A kind of inactivated lactobacillus microecological agent of Rich in Trace Element and preparation method thereof |
CN114574387A (en) * | 2022-03-03 | 2022-06-03 | 江南大学 | High-enrichment organic zinc animal bifidobacterium for promoting growth and reproductive development |
CN116491583A (en) * | 2023-04-27 | 2023-07-28 | 生物源生物技术(深圳)股份有限公司 | Microcapsule with gastrointestinal tract regulating function and preparation method and application thereof |
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CN101366448A (en) * | 2007-08-15 | 2009-02-18 | 胡文锋 | Environment-friendly acidulant |
CN101792720A (en) * | 2009-05-12 | 2010-08-04 | 广州市博善生物饲料有限公司 | Production method of selenium-enriched yeast culture |
CN101803684A (en) * | 2010-04-16 | 2010-08-18 | 胡文锋 | Enteric zinc oxide and method for preparing same |
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《中国优秀硕士学位论文全文数据库》 20091231 赵治平 富硒锌益生菌制剂研制及其在犬上的初步应用 27,35-36 1-10 , 第8期 * |
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Cited By (23)
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CN103146611A (en) * | 2013-03-12 | 2013-06-12 | 通威股份有限公司 | Preparation method for composite-type lactobacillus microecological preparation |
CN103283973A (en) * | 2013-03-20 | 2013-09-11 | 广州格拉姆生物科技有限公司 | A method for producing a probiotic agent of live Lactobacillus acidophilus |
CN103211143A (en) * | 2013-03-26 | 2013-07-24 | 胡文锋 | Inactivated lactobacillus effervescent tablets and preparation method thereof |
CN103602707A (en) * | 2013-04-25 | 2014-02-26 | 胡文锋 | Bio-synthesis method of nano zinc oxide by utilizing lactic acid bacteria and nano zinc oxide composite feed addictive |
CN103602707B (en) * | 2013-04-25 | 2015-11-18 | 胡文锋 | A kind of method and nano zine oxide composite feed additive utilizing lactic acid bacteria biological synthesis of nano-zinc oxide |
CN104721237A (en) * | 2013-12-22 | 2015-06-24 | 青岛碧水蓝天生物技术有限公司 | Lactobacillus microecological preparation used in intestinal tract disease treatment drugs |
CN103750341A (en) * | 2014-01-13 | 2014-04-30 | 苏州万生源生物科技有限公司 | Inactivated bacteroid micro-ecological preparation and preparation method thereof |
CN103977025A (en) * | 2014-04-30 | 2014-08-13 | 南昌大学 | Bacteriostatic composition of lactobacillus plantarum fermentation liquid and nano zinc oxide |
CN103977032A (en) * | 2014-04-30 | 2014-08-13 | 南昌大学 | Novel bacteriostatic composition containing bifidobacteria fermented liquid |
CN103977025B (en) * | 2014-04-30 | 2017-09-29 | 南昌大学 | Lactobacillus plantarum zymotic fluid and nano zine oxide bacteria inhibiting composition |
CN104357360B (en) * | 2014-11-14 | 2016-01-20 | 湖南农业大学 | A kind of feeding addicted to sour micrococcus liquid raw material fermentation substratum and fermentation process |
CN104357360A (en) * | 2014-11-14 | 2015-02-18 | 湖南农业大学 | Pediococcus acidilactici liquid raw material fermentation medium for feed and fermentation method |
CN104957373A (en) * | 2015-06-10 | 2015-10-07 | 山东省农业科学院畜牧兽医研究所 | Method for reducing heavy metal emission in livestock and poultry manure |
CN104957373B (en) * | 2015-06-10 | 2018-07-24 | 山东省农业科学院畜牧兽医研究所 | The preparation method of the feed of heavy metals emission in a kind of reduction feces of livestock and poultry |
US11382940B2 (en) | 2016-08-09 | 2022-07-12 | Cj Cheiljedang Corporation | Lactobacillus salivarius CJLS1511, animal feed additive composition comprising same bacterium or dead cells thereof, and method for producing same dead cells |
CN109563473A (en) * | 2016-08-09 | 2019-04-02 | Cj第制糖株式会社 | Lactobacillus salivarius CJLS1511, the method added composition containing the animal feed of the bacterium or dead cell and produce dead cell |
CN108841763A (en) * | 2018-07-20 | 2018-11-20 | 江苏微康生物科技有限公司 | A kind of preparation method of zinc dense plants lactobacillus additive |
CN109984260A (en) * | 2019-04-12 | 2019-07-09 | 生物源生物技术(深圳)股份有限公司 | A kind of inactivated lactobacillus microecological agent of Rich in Trace Element and preparation method thereof |
CN114574387A (en) * | 2022-03-03 | 2022-06-03 | 江南大学 | High-enrichment organic zinc animal bifidobacterium for promoting growth and reproductive development |
CN114574387B (en) * | 2022-03-03 | 2023-08-25 | 江南大学 | High-enrichment organic zinc animal bifidobacterium for promoting growth and reproductive development |
WO2023165607A1 (en) * | 2022-03-03 | 2023-09-07 | 江南大学 | Strain of high organic zinc enrichment bifidobacterium animalis for promoting growth and reproductive development |
CN116491583A (en) * | 2023-04-27 | 2023-07-28 | 生物源生物技术(深圳)股份有限公司 | Microcapsule with gastrointestinal tract regulating function and preparation method and application thereof |
CN116491583B (en) * | 2023-04-27 | 2024-06-18 | 生物源生物技术(深圳)股份有限公司 | Microcapsule with gastrointestinal tract regulating function and preparation method and application thereof |
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