CN101971839A - Bactericidal composition containing cyproconazole - Google Patents
Bactericidal composition containing cyproconazole Download PDFInfo
- Publication number
- CN101971839A CN101971839A CN2010105520767A CN201010552076A CN101971839A CN 101971839 A CN101971839 A CN 101971839A CN 2010105520767 A CN2010105520767 A CN 2010105520767A CN 201010552076 A CN201010552076 A CN 201010552076A CN 101971839 A CN101971839 A CN 101971839A
- Authority
- CN
- China
- Prior art keywords
- cyproconazole
- bactericidal composition
- mancozeb
- zineb
- weight ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UFNOUKDBUJZYDE-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Chemical compound C1=NC=NN1CC(O)(C=1C=CC(Cl)=CC=1)C(C)C1CC1 UFNOUKDBUJZYDE-UHFFFAOYSA-N 0.000 title claims abstract description 97
- 239000005757 Cyproconazole Substances 0.000 title claims abstract description 97
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 31
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 80
- 239000005802 Mancozeb Substances 0.000 claims abstract description 48
- 239000011717 all-trans-retinol Substances 0.000 claims abstract description 40
- 235000019169 all-trans-retinol Nutrition 0.000 claims abstract description 40
- 241000221785 Erysiphales Species 0.000 claims abstract description 12
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 9
- 239000000375 suspending agent Substances 0.000 claims description 17
- 230000035613 defoliation Effects 0.000 claims description 3
- AMHNZOICSMBGDH-UHFFFAOYSA-L zineb Chemical compound [Zn+2].[S-]C(=S)NCCNC([S-])=S AMHNZOICSMBGDH-UHFFFAOYSA-L 0.000 claims description 2
- 241000219122 Cucurbita Species 0.000 claims 1
- 235000009852 Cucurbita pepo Nutrition 0.000 claims 1
- 235000012055 fruits and vegetables Nutrition 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 7
- 241000223600 Alternaria Species 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 239000012752 auxiliary agent Substances 0.000 abstract description 2
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 22
- -1 antifreeze Substances 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 238000012360 testing method Methods 0.000 description 13
- 240000008067 Cucumis sativus Species 0.000 description 11
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 230000003449 preventive effect Effects 0.000 description 11
- 239000002131 composite material Substances 0.000 description 10
- 230000001018 virulence Effects 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 239000006185 dispersion Substances 0.000 description 9
- 239000008187 granular material Substances 0.000 description 9
- ZEVCJZRMCOYJSP-UHFFFAOYSA-N sodium;2-(dithiocarboxyamino)ethylcarbamodithioic acid Chemical compound [Na+].SC(=S)NCCNC(S)=S ZEVCJZRMCOYJSP-UHFFFAOYSA-N 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- 229920002472 Starch Polymers 0.000 description 8
- 239000000575 pesticide Substances 0.000 description 8
- 229920005646 polycarboxylate Polymers 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 241000233679 Peronosporaceae Species 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 241000220223 Fragaria Species 0.000 description 5
- 235000016623 Fragaria vesca Nutrition 0.000 description 5
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 5
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 150000004996 alkyl benzenes Chemical class 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- 239000003899 bactericide agent Substances 0.000 description 4
- 210000000481 breast Anatomy 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 238000009313 farming Methods 0.000 description 4
- 230000000855 fungicidal effect Effects 0.000 description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 229920001732 Lignosulfonate Polymers 0.000 description 3
- 206010067482 No adverse event Diseases 0.000 description 3
- 240000003377 Shepherdia canadensis Species 0.000 description 3
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000000440 bentonite Substances 0.000 description 3
- 229910000278 bentonite Inorganic materials 0.000 description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 3
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 3
- 150000007942 carboxylates Chemical class 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 235000021003 saturated fats Nutrition 0.000 description 3
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 3
- 239000004563 wettable powder Substances 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 2
- 235000017060 Arachis glabrata Nutrition 0.000 description 2
- 244000105624 Arachis hypogaea Species 0.000 description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 description 2
- 235000018262 Arachis monticola Nutrition 0.000 description 2
- 235000016068 Berberis vulgaris Nutrition 0.000 description 2
- 241000335053 Beta vulgaris Species 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000002528 anti-freeze Effects 0.000 description 2
- 229940077388 benzenesulfonate Drugs 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 239000013530 defoamer Substances 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 235000020232 peanut Nutrition 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- JCUDAMKYTWVICI-UHFFFAOYSA-N 4-benzyl-2,3-dimethylphenol Chemical compound C1=C(O)C(C)=C(C)C(CC=2C=CC=CC=2)=C1 JCUDAMKYTWVICI-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- GIYOYTQPIBIOOJ-UHFFFAOYSA-N C(N)(=S)[Mn] Chemical compound C(N)(=S)[Mn] GIYOYTQPIBIOOJ-UHFFFAOYSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 229920005682 EO-PO block copolymer Polymers 0.000 description 1
- 241000510928 Erysiphe necator Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000221535 Pucciniales Species 0.000 description 1
- 241001515786 Rhynchosporium Species 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 241001533598 Septoria Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 241000317942 Venturia <ichneumonid wasp> Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- HEEYEDNZYXRUQB-UHFFFAOYSA-N benzene;carbamothioic s-acid Chemical class NC(S)=O.C1=CC=CC=C1 HEEYEDNZYXRUQB-UHFFFAOYSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- YKSNLCVSTHTHJA-UHFFFAOYSA-L maneb Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S YKSNLCVSTHTHJA-UHFFFAOYSA-L 0.000 description 1
- 229920000940 maneb Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000006365 thiocyanation reaction Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a bactericidal composition with synergistic effect. The effective active ingredients of the composition contain (A) cyproconazole and (B) one of zineb and mancozeb, wherein the weight ratio of the A to the B is 1:1-1:70. Auxiliary agents and excipients are added into the effective active ingredients to prepare water dispersible granules or suspension. The bactericidal composition is mainly used for preventing and controlling powdery mildew, anthracnose, ring spot and alternaria leaf spot.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains cyproconazole and zineb or mancozeb.
Technical background
Cyproconazole, (having another name called Cyproconazole) English name: Cyproconazole, molecular formula: C
15H
18ClN
3O, chemical name: 2-(4-chlorphenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl) fourth-2-alcohol.
Cyproconazole belongs to triazole bactericidal agent.Be sterol demethylation inhibitor, have prevention and therapeutic action.All effective to the Erysiphales on cereal crop, coffee, beet, fruit tree and the grape, Uredinales, the mould genus of genus spore, Rhynchosporium spp, Septoria, Venturia bacterium.Use with other bactericide, can fine cereal eye spot disease, leaf spot and the net blotch of preventing and treating.The control wheat rust lasting period was 4～6 weeks, and preventing and treating powdery mildew was 3～4 weeks.Cereal, fruit tree and grape powdery mildew, peanut, beet tops pinta, apple scab and peanut white rot.
Zineb (zineb), molecular formula are C
4H
6N
2S
4Zn, chemical name: zinc ethylenebisdithiocarbamate.
Zineb belongs to the benzene thiocarbamates; it is the protectant that a kind of foliage spray is used; to plant safety; the active ingredient chemical property is more active, easily is oxidized to different thiocyanation compound in water, to the cause of disease thalline contain-enzyme of SH base has had strong inhibitory effects; and the direct kill pathogens spore of energy; suppress the germination of spore, stop in the germ invaded plants body, but very little to the mycelial lethal effect of cause of disease in the invaded plants body.
Mancozeb (mancozeb) molecular formula: C
4H
6N
2S
4MnZn chemical name: the complex salt of two two thiocarbamoyl manganese of ethylene and zinc.
Mancozeb is the complex that maneb and zinc are formed, and belongs to the wider protective fungicide of fungicidal spectrum.It mainly is the oxidation that suppresses pyruvic acid in the thalline.Effective to multiple diseases such as the anthracnose on fruit tree, the vegetables, early blight, simultaneously its normal and systemic fungicide is mixed, and is used for the generation of delaying drug resistance.
No matter be cyproconazole, zineb (mancozeb) or other efficient germicides, long-term use separately makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.And a kind ofly do not have the novel pesticide of cross resistance to prevent and treat pathogen if want newly developed, and then need screen 10,000～1.5 ten thousand compounds, expensive 1～1.5 hundred million dollar, the construction cycle is 6～10 years.And that the active ingredient of the different mechanisms of action is carried out is composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.
Cyproconazole is different with zineb (mancozeb) mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about cyproconazole and zineb (mancozeb) do not see relevant report at present at home and abroad as yet.
Summary of the invention
The objective of the invention is to propose a kind of generation or delaying drug resistance speed that can prevent disease drug resistance, the bactericidal composition that use cost is low, preventive effect is good.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains cyproconazole, wherein cyproconazole and zineb or mancozeb weight ratio are 1: 1～1: 70.
The described bactericidal composition that contains cyproconazole, wherein the weight ratio of cyproconazole and zineb or mancozeb is 1: 3～1: 30.。
The described bactericidal composition that contains cyproconazole, wherein the weight ratio of cyproconazole and zineb or mancozeb is 1: 5～1: 10.
The described bactericidal composition that contains cyproconazole, wherein the weight ratio of cyproconazole and zineb or mancozeb is 1: 5～1: 7.
The described bactericidal composition that contains the cyproconazole connection, wherein the effective active component content accounts for 1～90% of gross weight, is preferably 10～80%.
The described bactericidal composition that contains cyproconazole is according to method known in those skilled in the art, adds corresponding additive and filler, make agricultural and go up any formulation that allows, more preferably as: water dispersible granules or suspending agent.
Described auxiliary agent has dispersant, wetting agent, disintegrant, binding agent, defoamer, antifreeze, thickener.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described binding agent is selected from: one or more in diatomite, starch, PVA, carboxymethyl (ethyl) cellulose.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, the glucose.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), farming breast 1600
#In (phenethyl phenol polyoxy ethyl polypropylene-base ether), the ethylene oxide-propylene oxide block copolymer one or more.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in control oomycetes order disease such as powdery mildew, anthracnose, ring spot, spot defoliation etc.
Beneficial effect of the present invention: (1) present composition effective active composition cyproconazole and zineb or mancozeb belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition shows good synergistic effect in given scope, and preventive effect is apparently higher than single agent, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, anthracnose, ring spot, the spot defoliation of vegetables and fruit tree.
Embodiment
To further instruction of the present invention, but the present invention is not limited thereto below in conjunction with embodiment.Percentage in following examples all is weight percentage.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one: cyproconazole and zineb (or mancozeb) are composite to the cucumber downy mildew Toxicity Determination
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament cucumber downy mildew.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively cyproconazole and zineb (or mancozeb) shared ratio in combination
A is a cyproconazole
B is zineb (or mancozeb)
Result of the test is as shown in the table:
Table 1 cyproconazole, zineb and composite toxicity test analysis of results table thereof to cucumber downy mildew
As shown in Table 1, cyproconazole, zineb are to the EC of cucumber downy mildew
50Be respectively 3.48mg/L and 39.36mg/L.The virulence of cyproconazole is higher than the virulence of zineb.The virulence of cyproconazole is apparently higher than the virulence of zineb.Cyproconazole and zineb were mixed in the scope at 1: 1～1: 70 and all show obvious synergistic effect.Wherein, both mixed synergies in 1: 3～1: 30 scope are comparatively desirable, and mixed synergies is particularly outstanding in 1: 5～1: 7 scope.
Table 2 cyproconazole, mancozeb and composite toxicity test analysis of results table thereof to cucumber downy mildew
As shown in Table 1, cyproconazole, mancozeb are to the EC of cucumber downy mildew
50Be respectively 3.84mg/L and 42.54mg/L.The virulence of cyproconazole is higher than the virulence of mancozeb.The virulence of cyproconazole is apparently higher than the virulence of mancozeb.Cyproconazole and mancozeb were mixed in the scope at 1: 1～1: 70 and all show obvious synergistic effect.Wherein, both mixed synergies in 1: 3～1: 30 scope are comparatively desirable, and mixed synergies is particularly outstanding in 1: 5～1: 7 scope.
Implementation of an application example two the implementation of Formulation Example
(1) cyproconazole zineb:
Embodiment 1 80% cyproconazole water dispersion granules agent of dithane
Cyproconazole 10%, zineb 70%, alkylphenol-polyethenoxy are phonetic 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, starch 5%, kaolin 5%, mixed 80% cyproconazole water dispersion granules agent of dithane.
Embodiment 2 70% cyproconazole water dispersion granules agent of dithane
Cyproconazole 10%, zineb 60%, polycarboxylate 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, starch 7%, kaolin 10%, the mixed 70% cyproconazole water dispersion granules agent of dithane that gets.
Embodiment 3 62% cyproconazole water dispersion granules agent of dithane
Cyproconazole 2%, zineb 60%, alkylphenol-polyethenoxy are phonetic 5%, dodecyl benzene sulfonate 3%, starch 18%, bentonite 22%, mixed 52% cyproconazole water dispersion granules agent of dithane.
Embodiment 4 40% cyproconazole zineb suspending agents
Cyproconazole 10%, zineb 30%, alkyl benzene sulfonate calcium salt 5%, Sodium Polyacrylate 2%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, phenyl phenol polyoxy ethyl ether 2%, deionized water adds to 100%, the mixed 40% cyproconazole zineb suspending agent that gets.
Embodiment 5 30% cyproconazole zineb suspending agents
Cyproconazole 5%, zineb 15%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, alkyl benzene calcium sulfonate 2%, deionized water adds to 100%, the mixed 30% cyproconazole zineb suspending agent that gets.
Embodiment 6 28% cyproconazole zineb suspending agents
Cyproconazole 4%, zineb 24%, polycarboxylate 2%, Nekal BX 2%, C10-20 saturated fat acid compounds 0.1%, polyethylene glycol 0.5%, ethylene glycol 4%, phenethyl phenol polyoxy ethyl polypropylene-base ether 1%, deionized water adds to 100%, the mixed 28% cyproconazole zineb suspending agent that gets.
(2) cyproconazole mancozeb
Embodiment 7 80% cyproconazole mancozeb water dispersible granules
Cyproconazole 20%, mancozeb 60%, alkylphenol-polyethenoxy are phonetic 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, starch 10%, mixed 80% cyproconazole mancozeb water dispersible granule.
Embodiment 8 60% cyproconazole mancozeb water dispersible granules
Cyproconazole 5%, mancozeb 55%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, starch 7%, kaolin 10%, the mixed 60% cyproconazole mancozeb water dispersible granule that gets.
Embodiment 9 48% cyproconazole mancozeb water dispersible granules
Cyproconazole 8%, mancozeb 40%, alkylphenol-polyethenoxy are phonetic 4%, DBSA 4%, starch 15%, diatomite 22%, mixed 48% cyproconazole mancozeb water dispersible granule.
Embodiment 10 40% cyproconazole mancozeb suspending agents
Cyproconazole 20%, mancozeb 20%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, alkyl benzene calcium sulfonate 2%, deionized water adds to 100%, the mixed 40% cyproconazole mancozeb suspending agent that gets.
Embodiment 11 36% cyproconazole mancozeb suspending agents
Cyproconazole 6%, mancozeb 30%, polycarboxylate 2%, Nekal BX 2%, C10-20 saturated fat acid compounds 0.1%, polyethylene glycol 0.5%, ethylene glycol 4%, phenethyl phenol polyoxy ethyl polypropylene-base ether 1%, deionized water adds to 100%, the mixed 36% cyproconazole mancozeb suspending agent that gets.
Embodiment 12 15% cyproconazole mancozeb suspending agents
Cyproconazole 5%, mancozeb 10%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, phenethyl phenol polyoxy ethyl polypropylene-base ether 1%, deionized water adds to 100%, the mixed 15% cyproconazole mancozeb suspending agent that gets.
Embodiment uses three bactericidal compositions that contain cyproconazole and prevents and treats the powdery mildew of strawberry test of pesticide effectiveness
This experimental establishment is in suburb, Fuping County, Shaanxi Province, test medicine is researched and developed, is provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% water dispersion granules agent of dithane (commercial), 80% mancozeb wettable powder (commercial), 10% cyproconazole suspending agent (commercial).
The investigation powdery mildew of strawberry state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated the powdery mildew of strawberry disease index respectively and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
Table 3 contains the bactericidal composition control powdery mildew of strawberry test of pesticide effectiveness of cyproconazole
As can be seen from Table 3, can effectively prevent and treat powdery mildew of strawberry after cyproconazole and zineb or mancozeb are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.
Implementation of an application example four: the bactericidal composition control cucumber anthracnose test of pesticide effectiveness that contains cyproconazole
This experimental establishment is at the Xian City, Shanxi Province Changan District, test medicine is researched and developed, is provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% water dispersion granules agent of dithane (commercial), 80% mancozeb wettable powder (commercial), 10% cyproconazole suspending agent (commercial).
Investigation cucumber anthracnose state of an illness radix before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 4 contains the bactericidal composition control cucumber anthracnose test of pesticide effectiveness of cyproconazole
As can be seen from Table 4, can effectively prevent and treat cucumber anthracnose after cyproconazole and zineb or mancozeb are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and powdery mildew of cucumber had good preventive effect, preventive effect reaches more than 90%.
Implementation of an application example five: the bactericidal composition control alternaria leaf spot of apple test of pesticide effectiveness that contains cyproconazole
This experimental establishment is in Liang Jia village, Liquan County, Shaanxi Province, test medicine is researched and developed, is provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% water dispersion granules agent of dithane (commercial), 80% mancozeb wettable powder (commercial), 10% cyproconazole suspending agent (commercial).
Investigation alternaria leaf spot of apple state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 5 contains the bactericidal composition control alternaria leaf spot of apple test of pesticide effectiveness of cyproconazole
As can be seen from Table 5, can effectively prevent and treat alternaria leaf spot of apple after cyproconazole and zineb are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and preventive effect reaches more than 89.36%.
Claims (8)
1. bactericidal composition that contains cyproconazole is characterized in that bactericidal composition effective active composition (A) cyproconazole and (B) weight ratio of zineb or mancozeb are 1: 1～1: 70.
2. the bactericidal composition that contains cyproconazole according to claim 1 is characterized in that: wherein (A) cyproconazole is 1: 3～1: 30 with the weight ratio of (B) zineb or mancozeb.。
3. the bactericidal composition that contains cyproconazole according to claim 2 is characterized in that: wherein (A) cyproconazole is 1～5: 1～7 with (B) weight ratio of zineb.
4. the bactericidal composition that contains cyproconazole according to claim 2 is characterized in that: wherein (A) cyproconazole is 1～5: 1～7 with (B) weight ratio of mancozeb.
5. the bactericidal composition that contains cyproconazole according to claim 1 is characterized in that: wherein the effective active component content accounts for 1～90% of gross weight.
6. the bactericidal composition that contains cyproconazole according to claim 4 is characterized in that: wherein the effective active component content accounts for 10～80% of gross weight.
7. the bactericidal composition that contains cyproconazole according to claim 1 is characterized in that: bactericidal composition is made water dispersible granules or suspending agent.
8. the bactericidal composition that contains cyproconazole and Carbatene according to claim 1 is used to prevent and treat powdery mildew, anthracnose, ring spot, the spot defoliation of gourd, fruit and vegetable.
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| CN105766957A (en) * | 2016-03-31 | 2016-07-20 | 太仓市东泾农场专业合作社 | Sterilization composition containing triazoles fungicide and mancozeb |
| EP3073826B1 (en) * | 2013-11-26 | 2019-10-30 | UPL Limited | A method for controlling soybean rust |
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| CN101384173A (en) * | 2006-02-14 | 2009-03-11 | 巴斯夫欧洲公司 | A method of using a micronutrient as safener for a triazole for controlling harmful fungi |
| CN101779677A (en) * | 2009-12-16 | 2010-07-21 | 陈章艳 | Sterilization composition containing penconazole |
| CN102334490A (en) * | 2010-07-23 | 2012-02-01 | 青岛奥迪斯生物科技有限公司 | High efficiency sterilization composition containing mancozeb and flusilazole |
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| CN101384173A (en) * | 2006-02-14 | 2009-03-11 | 巴斯夫欧洲公司 | A method of using a micronutrient as safener for a triazole for controlling harmful fungi |
| CN101779677A (en) * | 2009-12-16 | 2010-07-21 | 陈章艳 | Sterilization composition containing penconazole |
| CN102334490A (en) * | 2010-07-23 | 2012-02-01 | 青岛奥迪斯生物科技有限公司 | High efficiency sterilization composition containing mancozeb and flusilazole |
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| EP3073826B1 (en) * | 2013-11-26 | 2019-10-30 | UPL Limited | A method for controlling soybean rust |
| EP4014741A1 (en) * | 2013-11-26 | 2022-06-22 | UPL Ltd | A method for controlling rust |
| CN105766957A (en) * | 2016-03-31 | 2016-07-20 | 太仓市东泾农场专业合作社 | Sterilization composition containing triazoles fungicide and mancozeb |
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Address after: 715500 Pucheng County of Shaanxi Province agricultural base industrial park Applicant after: Shaanxi Meibang Pesticide Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Applicant before: Shaanxi Meibang Pesticide Co., Ltd. |
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Application publication date: 20110216 |