CN101966225A - Preparation method of semifluid extract of motherwort - Google Patents
Preparation method of semifluid extract of motherwort Download PDFInfo
- Publication number
- CN101966225A CN101966225A CN 201010500567 CN201010500567A CN101966225A CN 101966225 A CN101966225 A CN 101966225A CN 201010500567 CN201010500567 CN 201010500567 CN 201010500567 A CN201010500567 A CN 201010500567A CN 101966225 A CN101966225 A CN 101966225A
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- CN
- China
- Prior art keywords
- motherwort
- herba leonuri
- hours
- filtrate
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 title abstract 7
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 title abstract 7
- 241000207925 Leonurus Species 0.000 title abstract 6
- 239000000706 filtrate Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000002156 mixing Methods 0.000 claims abstract description 8
- AOFUBOWZWQFQJU-SNOJBQEQSA-N (2r,3s,4s,5r)-2,5-bis(hydroxymethyl)oxolane-2,3,4-triol;(2s,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O AOFUBOWZWQFQJU-SNOJBQEQSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 abstract description 8
- 239000000047 product Substances 0.000 abstract description 6
- 239000006071 cream Substances 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 230000006378 damage Effects 0.000 abstract description 2
- 240000007890 Leonurus cardiaca Species 0.000 abstract 1
- 229960004903 invert sugar Drugs 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000002791 soaking Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 238000012797 qualification Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种益母草膏的制备方法，按如下步骤进行：①将切碎的益母草在水中浸润至少3小时；②加至5～8倍量水在80℃以下煎煮至少两次，每次煎2小时，过滤得滤液，合并滤液；③将步骤B中的滤液在80℃以下浓缩至相对密度为1.21-1.25的浸膏；④将所述浸膏与转化糖按1比2重量份的比例均匀混合即得益母草膏。本发明采用将浸膏与事先制备的转化糖进行均匀混合的方法，可避免在高温长时间煎煮过程中对益母草中有效成分的破坏，因此可使产品的合格率大为提高，以本发明方法制备的益母草膏按药典标准检测产品合格率大于98％。The invention discloses a preparation method of motherwort paste, which is carried out according to the following steps: ① Soak the chopped motherwort in water for at least 3 hours; Decoct for 2 hours, filter the filtrate, and combine the filtrates; ③concentrate the filtrate in step B below 80°C to an extract with a relative density of 1.21-1.25; The ratio of motherwort is evenly mixed to get motherwort cream. The present invention adopts the method of uniformly mixing the extract and the invert sugar prepared in advance, which can avoid the damage to the active ingredients in Motherwort during the long-term decoction at high temperature, so that the qualified rate of the product can be greatly improved. The motherwort ointment prepared by the method has a qualified rate of more than 98% according to the pharmacopoeia standard.
Description
Technical field:
The present invention relates to a kind of preparation method of Herba Leonuri paste.
Background technology:
Herba Leonuri is as raw material, the Chinese crude drug of medicine preparation, and its this product and manufactured goods can be used for treating gynaecopathia in clinical, as menoxenia, puerperal congestion, stomachache and other gynaecopathia.Herba Leonuri be the treatment above disease medical material in a kind of, clinical use is extensive, therapeutic effect is good, is traditional TCM Gynecology Chinese patent drug.The Herba Leonuri clinical effectiveness effective ingredient-stachydrine contained with it is closely related, has only content to reach under the Chinese Pharmacopoeia requirement situation, and its therapeutic effect just can reach assurance.At present, Herba Leonuri paste roughly adopts following preparation method production: the Herba Leonuri of chopping is decocted with water twice, each 2 hours, collecting decoction filters, under 80 ℃ of conditions, be the extractum of 1.21-1.25 with filtrate simmer down to relative density, dissolve in the ratio heating that per 100 gram extractum add 200 gram brown sugar, mixing, the relative density that is concentrated into regulation promptly, the drawback of its existence is: 1, the Herba Leonuri with chopping directly decocts with water, Herba Leonuri floats on the water surface, causes the active ingredient in the Herba Leonuri fully not extracted.2, become the operational approach in cream stage improper, directly decocting about 4 hours under 110 ℃ of conditions with brown sugar because of adopting extractum, cause in the Herba Leonuri effective ingredient-stachydrine destroyed, active constituent content reduces greatly.Provide though above preparation method is a pharmacopeia, according to said method be difficult to produce qualified Herba Leonuri paste, cause at present this product is in situation in short supply substantially on market.
Summary of the invention:
For overcoming the defective of prior art, the object of the present invention is to provide a kind of preparation method of Herba Leonuri paste, adopt the method in the process of preparation Herba Leonuri paste, the effective ingredient in the Herba Leonuri is not destroyed, improve product percent of pass greatly.
Technical solution problem of the present invention adopts following technical scheme:
A kind of preparation method of Herba Leonuri paste, carry out as follows:
A, with the chopping Herba Leonuri in water, soaked at least 3 hours;
B, add to 5～8 times of water gagings, fried in shallow oil 2 hours at every turn, filter to get filtrate merging filtrate decocting at least twice below 80 ℃;
C, the filtrate among the step B is being concentrated into the extractum that relative density is 1.21-1.25 below 80 ℃;
D, described extractum and Nulomoline are promptly got Herba Leonuri paste in the ratio uniform mixing of 1 to 2 weight portion.
Compared with the prior art, beneficial effect of the present invention is embodied in:
1, preparation method of the present invention is before producing the Herba Leonuri extracting solution, earlier Herba Leonuri was soaked into 3 hours in water at least, can avoid Herba Leonuri when extracting, to float on the phenomenon of the water surface like this, moreover, after long-time the infiltration, the cell wall of Herba Leonuri is lax, the cell hole expansion, and feasible extraction effect to its effective ingredient improves greatly.
2, becoming the cream stage, earlier brown sugar is prepared into qualified Nulomoline, and then make Herba Leonuri paste with the Herba Leonuri extractum uniform mixing, become for the Nulomoline with respect in the existing method extractum is decocted jointly (under 110 ℃ of conditions about 4 hours) with brown sugar, the destruction of effective ingredient in can avoiding in the long-time decoction process of high temperature Herba Leonuri, therefore the qualification rate of product is greatly improved, press standards of pharmacopoeia testing product qualification rate greater than 98% with the Herba Leonuri paste of the inventive method preparation.
The specific embodiment:
Embodiment 1: the preparation of present embodiment Herba Leonuri paste, carry out as follows:
A, elder generation soak into the Herba Leonuri of chopping 3 hours in the water of capacity;
B, Herba Leonuri continue to add water to 8 times of amounts after soaking into, and decoct twice at (under the condition of negative pressure) below 80 ℃, fry in shallow oil 2 hours at every turn, filter to get filtrate merging filtrate;
C, the filtrate with previous step in rapid are being concentrated into the extractum that relative density is 1.21-1.25 below 80 ℃;
D, extractum that above-mentioned steps is made and Nulomoline promptly get Herba Leonuri paste in the ratio uniform mixing of 1 to 2 (weight portion).
Embodiment 2: the preparation of present embodiment Herba Leonuri paste, carry out as follows:
A, elder generation soak into the Herba Leonuri of chopping 4 hours in the water of capacity;
B, Herba Leonuri continue to add water to 6 times of amounts after soaking into, and decoct twice at (under the condition of negative pressure) below 80 ℃, fry in shallow oil 2 hours at every turn, filter to get filtrate merging filtrate;
C, the filtrate with previous step in rapid are being concentrated into the extractum that relative density is 1.21-1.25 below 80 ℃;
D, extractum that above-mentioned steps is made and Nulomoline promptly get Herba Leonuri paste in the ratio uniform mixing of 1 to 2 (weight portion).
Embodiment 3: the preparation of present embodiment Herba Leonuri paste, carry out as follows:
A, elder generation soak into the Herba Leonuri of chopping 5 hours in the water of capacity;
B, Herba Leonuri continue to add water to 5 times of amounts after soaking into, and decoct twice at (under the condition of negative pressure) below 80 ℃, fry in shallow oil 2 hours at every turn, filter to get filtrate merging filtrate;
C, the filtrate with previous step in rapid are being concentrated into the extractum that relative density is 1.21-1.25 below 80 ℃;
D, extractum that above-mentioned steps is made and Nulomoline promptly get Herba Leonuri paste in the ratio uniform mixing of 1 to 2 (weight portion).
Claims (1)
1. the preparation method of a Herba Leonuri paste is characterized in that carrying out as follows:
A, with the chopping Herba Leonuri in water, soaked at least 3 hours;
B, add to 5～8 times of water gagings, fried in shallow oil 2 hours at every turn, filter to get filtrate merging filtrate decocting at least twice below 80 ℃;
C, the filtrate among the step B is being concentrated into the extractum that relative density is 1.21-1.25 below 80 ℃;
D, described extractum and Nulomoline are promptly got Herba Leonuri paste in the ratio uniform mixing of 1 to 2 weight portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010500567A CN101966225B (en) | 2010-09-30 | 2010-09-30 | Preparation method of semifluid extract of motherwort |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010500567A CN101966225B (en) | 2010-09-30 | 2010-09-30 | Preparation method of semifluid extract of motherwort |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101966225A true CN101966225A (en) | 2011-02-09 |
| CN101966225B CN101966225B (en) | 2011-12-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010500567A Expired - Fee Related CN101966225B (en) | 2010-09-30 | 2010-09-30 | Preparation method of semifluid extract of motherwort |
Country Status (1)
| Country | Link |
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| CN (1) | CN101966225B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302546A (en) * | 2011-08-26 | 2012-01-04 | 太极集团重庆涪陵制药厂有限公司 | Method for preparing motherwort herb paste |
| CN103933116A (en) * | 2014-04-01 | 2014-07-23 | 回音必集团安徽制药有限公司 | Preparation process of herba leonuri paste |
| CN104189071A (en) * | 2014-09-17 | 2014-12-10 | 上海海虹实业(集团)巢湖今辰药业有限公司 | Preparation method of flavored motherwort paste |
| CN106668141A (en) * | 2015-11-06 | 2017-05-17 | 庞锦霞 | Motherwort herb syrup |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985882A (en) * | 2006-12-14 | 2007-06-27 | 营口奥达制药有限公司 | Compound motherwort tablet and its preparing method |
-
2010
- 2010-09-30 CN CN201010500567A patent/CN101966225B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985882A (en) * | 2006-12-14 | 2007-06-27 | 营口奥达制药有限公司 | Compound motherwort tablet and its preparing method |
Non-Patent Citations (2)
| Title |
|---|
| 《中医药导报》 20100531 严优芍 益母草不同提取方法的比较研究 第109－110页 1 第16卷, 第5期 2 * |
| 《中国中医急症》 20070831 张师愚等 益母草中生物碱的提取与益母草膜剂的制备 第980－981页 1 第16卷, 第8期 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302546A (en) * | 2011-08-26 | 2012-01-04 | 太极集团重庆涪陵制药厂有限公司 | Method for preparing motherwort herb paste |
| CN103933116A (en) * | 2014-04-01 | 2014-07-23 | 回音必集团安徽制药有限公司 | Preparation process of herba leonuri paste |
| CN104189071A (en) * | 2014-09-17 | 2014-12-10 | 上海海虹实业(集团)巢湖今辰药业有限公司 | Preparation method of flavored motherwort paste |
| CN106668141A (en) * | 2015-11-06 | 2017-05-17 | 庞锦霞 | Motherwort herb syrup |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101966225B (en) | 2011-12-28 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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Granted publication date: 20111228 Termination date: 20130930 |