CN101263900B - Preparation of corn filament soft capsule - Google Patents
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Abstract
本发明的玉米花丝软胶囊及其制备方法属于功能食品加工的技术领域。玉米花丝软胶囊由囊化液和囊壳胶膜组成,组分包括玉米花丝粉、明胶、甘油、植物油、蜂蜡、维生素E、维生素C、色素、对羟基苯甲酸甲酯等。制备方法是以玉米花丝粉为主料;经玉米花丝粉制备、囊化液调配、囊壳胶膜制备、软胶囊丸制备的过程制得玉米花丝软胶囊。本发明有效利用玉米花丝资源,制得的玉米花丝软胶囊不但含有玉米花丝黄酮类、糖类、甾醇类等功效成分及其功效特性,而且还兼顾了软胶囊保健食品剂型所具有的饮用方便、贮藏方法简单、保质期长等特点,市场前景广阔。The corn silk soft capsule and the preparation method thereof of the present invention belong to the technical field of functional food processing. Corn silk soft capsule is composed of encapsulation liquid and capsule shell film, and its components include corn silk powder, gelatin, glycerin, vegetable oil, beeswax, vitamin E, vitamin C, pigment, methyl p-hydroxybenzoate, etc. The preparation method uses corn silk powder as the main ingredient; the corn silk soft capsule is prepared through the processes of preparation of corn silk powder, formulation of encapsulation solution, preparation of capsule shell film and preparation of soft capsule pills. The present invention effectively utilizes corn silk resources, and the prepared corn silk soft capsules not only contain corn silk flavonoids, sugars, sterols and other functional components and functional properties, but also take into account the convenience of drinking, the health food dosage form of soft capsules, The storage method is simple, the shelf life is long, etc., and the market prospect is broad.
Description
技术领域 technical field
本发明属于功能食品加工的技术领域,特别涉及玉米花丝赋型于软胶囊保健食品剂型的生产技术。 The invention belongs to the technical field of functional food processing, and in particular relates to the production technology of forming corn silk into the dosage form of soft capsule health food. the
背景技术 Background technique
玉米花丝是传统中药,含有甾醇类、糖类、黄酮类、有机酸、维生素、生物碱、皂苷、肌醇、隐黄质、尿囊素等多种功效成分,其药用价值主要体现在以下几个方面: Corn silk is a traditional Chinese medicine, which contains sterols, sugars, flavonoids, organic acids, vitamins, alkaloids, saponins, inositol, cryptoxanthin, allantoin and other functional ingredients. Its medicinal value is mainly reflected in the following several aspects:
(1)降血糖、降血压、降血脂作用 (1) Lowering blood sugar, lowering blood pressure, lowering blood fat
《中药大辞典》记载,民间应用玉米花丝治疗糖尿病取得了较好的疗效。动物实验表明,玉米花丝多糖能够调节糖尿病小鼠的糖代谢,促进糖异生,对四氧嘧啶所至的血糖升高有明显降糖作用;玉米花丝总皂苷具有较好的降糖活性,对抗病因性糖尿病模型的胰岛损伤具有明显的保护作用,也是玉米花丝降糖的主要活性成分之一。此外,玉米花丝水提物对高血压具有明显的降压作用,而对血压正常者无影响。 "Dictionary of Chinese Medicine" records that the folk application of corn silk to treat diabetes has achieved good curative effect. Animal experiments have shown that corn silk polysaccharides can regulate glucose metabolism in diabetic mice, promote gluconeogenesis, and have a significant hypoglycemic effect on the increase in blood sugar caused by alloxan; corn silk total saponins have good hypoglycemic activity and can resist The islet injury of etiological diabetes model has obvious protective effect, and it is also one of the main active ingredients of corn silk for hypoglycemic effect. In addition, corn silk water extract has obvious antihypertensive effect on hypertension, but has no effect on normal blood pressure. the
(2)免疫调节作用 (2) Immunomodulatory effect
医学研究表明:机体组织细胞的凋亡、疾病的发生或多或少都与机体免疫系统的结构组成和免疫功能有关。如果正常机体的免疫系统不能对细胞的凋亡进行调控,相应组织器官就会发生病变,如肿瘤、肝炎。玉米花丝中含有的多糖、黄酮等功效成分安全无毒,具有较好免疫活性和抗氧化能力,能显著提高机体免疫力。主要表现为,缓解疲劳,抗肿瘤,抗衰老。 Medical research shows that the apoptosis of body tissue cells and the occurrence of diseases are more or less related to the structural composition and immune function of the body's immune system. If the immune system of the normal body cannot regulate the apoptosis of the cells, the corresponding tissues and organs will have pathological changes, such as tumors and hepatitis. The functional ingredients such as polysaccharides and flavonoids contained in corn silk are safe and non-toxic, have good immune activity and antioxidant capacity, and can significantly improve the body's immunity. The main performance is to relieve fatigue, anti-tumor, and anti-aging. the
(3)清热利胆作用 (3) The effect of clearing heat and promoting gallbladder
玉米花丝多糖能明显增强胆汁分泌量,促进胆囊收缩,降低胆囊重量,具有明显的清热利胆作用。 Corn silk polysaccharides can significantly increase bile secretion, promote gallbladder contraction, reduce gallbladder weight, and have obvious heat-clearing and choleretic effects. the
(4)利尿、通便,抑制结石作用 (4) Diuretic, laxative, and stone-inhibiting effects
玉米花丝水提物能延长胃排空时间,使肠蠕动加速,排便次数增加;降低肾草酸含量并抑制草酸钙结晶的形成,从而抑制草酸盐类结石的产生。 The aqueous extract of corn silk can prolong the gastric emptying time, accelerate intestinal peristalsis, and increase the frequency of defecation; reduce the content of oxalic acid in the kidney and inhibit the formation of calcium oxalate crystals, thereby inhibiting the generation of oxalate stones. the
此外,《中药大辞典》记载,玉米花丝低毒;美国食品药物管理局确认玉米花丝为安全、无毒的物质,且玉米花丝提取物所制药品也确认为非处方药。玉米花丝在美国已公认是安全的。 In addition, the "Dictionary of Traditional Chinese Medicine" records that corn silk is low in toxicity; the US Food and Drug Administration has confirmed that corn silk is a safe and non-toxic substance, and the medicine made from corn silk extract is also confirmed as an over-the-counter drug. Filigree corn has been recognized as safe in the United States. the
目前,国内外市场上还没有以玉米花丝为主要原料开发研制的软胶囊产品。 At present, there is no soft capsule product developed with corn silk as the main raw material in the domestic and foreign markets. the
发明内容 Contents of the invention
本发明要解决的技术问题是:公开一种玉米花丝软胶囊的组分及各组分含量,公开制备玉米花丝软胶囊的方法。本发明所研制的玉米花丝软胶囊不但含有玉米花丝黄酮类、糖类、甾醇类等功效成分及其功效特性,而且还兼顾了软胶囊保健食品剂型所具有的饮用方便、贮藏方法简单、保质期长等特点。 The technical problem to be solved by the invention is to disclose the components and the content of each component of a corn silk soft capsule, and disclose a method for preparing the corn silk soft capsule. The corn filament soft capsule developed by the present invention not only contains corn filament flavonoids, sugars, sterols and other functional components and their functional properties, but also takes into account the convenience of drinking, simple storage method and long shelf life of the soft capsule health food dosage form. Features. the
本发明采用的技术方案如下: The technical scheme that the present invention adopts is as follows:
一种玉米花丝软胶囊,由囊化液和囊壳胶膜组成,其特征在于,以玉米花丝粉为主料,所述的囊化液各组分及其含量的质量份计为:玉米花丝粉9~20份、植物油80~91份、蜂蜡2~7.5份、维生素E 0.2~0.5份、维生素C 0~0.5份;所述的囊壳胶膜各组分及其按质量份计为:明胶2份、水0.2~0.3份、甘油0.6~1.5份、色素0.015~0.025份、对羟基苯甲酸甲酯0.005~0.015份。 A corn silk soft capsule, which is composed of an encapsulation liquid and a capsule shell film, is characterized in that corn silk powder is used as the main ingredient, and the mass parts of the components of the encapsulation liquid and their contents are: corn silk 9 to 20 parts of powder, 80 to 91 parts of vegetable oil, 2 to 7.5 parts of beeswax, 0.2 to 0.5 parts of vitamin E, and 0 to 0.5 parts of vitamin C; the components of the capsule shell film and their parts by mass are: 2 parts of gelatin, 0.2-0.3 parts of water, 0.6-1.5 parts of glycerin, 0.015-0.025 parts of pigment, 0.005-0.015 parts of methyl p-hydroxybenzoate. the
所述的玉米花丝粉,是玉米花丝经筛选、浸泡、清洗、烘干、粉碎得到的,颗粒度控制在70~200目。 The corn silk powder is obtained by screening, soaking, washing, drying and pulverizing the corn silk, and the particle size is controlled at 70-200 mesh. the
玉米花丝软胶囊的制备方法,以玉米花丝粉为主料;经玉米花丝粉制备、囊化液调配、囊壳胶膜制备、软胶囊丸制备的过程制得玉米花丝软胶囊; The preparation method of the corn silk soft capsule is based on the corn silk powder; the corn silk soft capsule is prepared through the processes of preparation of corn silk powder, formulation of encapsulation solution, preparation of capsule shell film, and preparation of soft capsule pills;
所述的玉米花丝粉制备过程,是将玉米花丝剔除霉变部分,用水浸泡再流水冲洗反复操作2~4次,采用烘干粉碎或者湿料粉碎烘干至颗粒度在70~200目; The preparation process of the corn filament powder is to remove the moldy part of the corn filament, soak it in water and then rinse it with running water for 2 to 4 times, and then use drying and crushing or wet material crushing and drying until the particle size is 70 to 200 mesh;
所述的囊化液调配过程,是将蜂蜡在70~90℃融化,按质量比例加入玉米花丝粉、植物油、维生素E、维生素C,在20~50℃搅拌使物料混合均匀,再经过胶体磨5~10次,20~50℃保温; The preparation process of the encapsulation solution is to melt beeswax at 70-90°C, add corn silk powder, vegetable oil, vitamin E, and vitamin C according to the mass ratio, stir at 20-50°C to mix the materials evenly, and then pass through the colloid mill 5~10 times, keep warm at 20~50℃;
所述的囊壳胶膜制备过程,是按各组分质量比例明胶2份、水2份、甘油0.6~1.5份、色素0.015~0.025份、对羟基苯甲酸甲酯0.005~0.015份备料,先将明胶和水投入至真空溶胶桶中,经5~40分钟的浸泡使明胶膨胀,在50~80℃下搅拌溶解,再加入甘油、色素、对羟基苯甲酸甲酯,混匀后再通过软胶囊主机控制下制得囊壳胶膜; The preparation process of the capsule shell film is to prepare materials according to the mass ratio of each component: 2 parts of gelatin, 2 parts of water, 0.6 to 1.5 parts of glycerin, 0.015 to 0.025 parts of pigment, and 0.005 to 0.015 parts of methyl p-hydroxybenzoate. Put the gelatin and water into the vacuum sol barrel, soak the gelatin for 5-40 minutes to expand the gelatin, stir and dissolve at 50-80°C, then add glycerin, pigment, methyl p-hydroxybenzoate, mix well and pass through the soft The capsule shell film is prepared under the control of the capsule host;
所述的软胶囊丸制备过程,是利用软胶囊机制备玉米花丝软胶囊丸,经定型、洗丸、晾丸、拣丸的过程制得成品。该过程于现有的胶囊丸剂食品的制丸过程相同。 The preparation process of the soft capsule pills is to use a soft capsule machine to prepare corn silk soft capsule pills, and to obtain finished products through the processes of setting the shape, washing the pills, drying the pills, and sorting the pills. This process is the same as the pill-making process of existing capsule pill food. the
在玉米花丝粉制备过程中,一般要浸泡冲洗2~4次,这是以农药残留各项指标控制在国家规定允许范围内为控制浸泡冲洗操作技术要点的;玉米花丝粉碎方式中,可以选用烘干粉碎或者选用湿料粉碎烘干的方式,至水分含量在3%~5%;若选用烘干粉碎时烘干温度应该控制在50℃~90℃,若选用湿料粉碎烘干时,烘干温度应该控制在40℃~80℃。 In the preparation process of corn silk powder, it is generally necessary to soak and rinse 2 to 4 times. This is to control the technical points of the soaking and washing operation by controlling the indicators of pesticide residues within the allowable range of national regulations; Dry crushing or wet material crushing and drying, until the moisture content is 3% to 5%; if drying and crushing is used, the drying temperature should be controlled at 50°C to 90°C; if wet material is crushed and dried, the drying temperature should be The drying temperature should be controlled between 40°C and 80°C. the
在囊化液调配过程中,胶体磨之后还可以进行7~15Mpa均质处理,使各组分混合得更均匀。 During the preparation process of the encapsulation solution, after the colloid mill, 7-15Mpa homogenization treatment can be carried out, so that the components can be mixed more evenly. the
在软胶囊丸制备过程中,更具体的可以是,利用软胶囊机制备玉米花丝软胶囊丸,输送至定型转炉中定型8~18小时;定型后浸于浓度为75%~95%乙醇中洗丸10~30秒;在相对湿度为35~45%、温度为21~25℃环境下晾丸10~24小时,之后检丸。检丸时,要剔除软胶囊丸形不均匀、不饱满的软胶囊丸。 In the soft capsule pill preparation process, it may be more specific to use a soft capsule machine to prepare corn silk soft capsule pills, and transport them to a shaping converter for shaping for 8 to 18 hours; Take the pills for 10-30 seconds; dry the pills for 10-24 hours in an environment with a relative humidity of 35-45% and a temperature of 21-25°C, and then check the pills. When inspecting the pills, the soft capsules with uneven and unfull shape should be rejected. the
吉林省是主要玉米产区,年种植面积达4000余万亩,除玉米及其精深加工产品研究开发外,对玉米须(玉米花丝)资源尚未有效利用,一般采取烧掉或废弃处理。所以,本发明开发玉米花丝软胶囊产品,能够将吉林省每年90余万吨玉米花丝作为功能食品新资源进行规模开发和利用,这将产生巨大的经济效益和社会效益。 Jilin Province is a major corn producing area, with an annual planting area of more than 40 million mu. Except for the research and development of corn and its deep-processing products, corn silk (corn silk) resources have not been effectively utilized, and are generally burned or discarded. Therefore, the invention develops the corn filament soft capsule product, which can use more than 900,000 tons of corn filament in Jilin Province as a new resource of functional food for large-scale development and utilization, which will generate huge economic and social benefits. the
本发明有效的利用了玉米花丝资源,所制得的玉米花丝软胶囊产品,不但含有玉米花丝黄酮类、糖类、甾醇类等功效成分及其功效特性,而且还兼顾了软胶囊保健食品剂型所具有的饮用方便、贮藏方法简单、保质期长等特点,真正体现出玉米花丝精深加工蕴涵的经济效益和社会效益,市场前景极其广阔。 The present invention effectively utilizes corn filament resources, and the prepared corn filament soft capsule product not only contains corn filament flavonoids, sugars, sterols and other functional ingredients and their functional properties, but also takes into account the health food formulations of soft capsules. It has the characteristics of convenient drinking, simple storage method and long shelf life, which truly reflects the economic and social benefits of deep processing of corn filigree, and has an extremely broad market prospect. the
具体实施方式 Detailed ways
实施例1: Example 1:
取干玉米花丝剔除霉变部分,用水浸泡再流水冲洗反复操作2次,烘干至水分含量3%,粉碎至颗粒度90目;烘干时温度控制在80~90℃。 Take the dried corn filaments and remove the mildewed parts, soak them in water and rinse them with running water twice, dry them until the moisture content is 3%, and crush them to a particle size of 90 mesh; the temperature during drying is controlled at 80-90°C. the
将12g蜂蜡在70℃融化,加入玉米花丝粉80g、植物油320g、维生素E 2g,在50℃搅拌使物料混合均匀,再经过胶体磨10次,50℃保温,得到软胶囊的囊 化液。 Melt 12g of beeswax at 70°C, add 80g of corn silk powder, 320g of vegetable oil, and 2g of vitamin E, stir at 50°C to mix the materials evenly, then pass through a colloid mill 10 times, and keep warm at 50°C to obtain the encapsulation liquid of the soft capsule. the
将明胶80g、水80g投入至真空溶胶桶中,经40分钟的浸泡使明胶膨胀,在80℃下搅拌溶解,再加入甘油40g、对羟基苯甲酸甲酯0.2g、亮黑色素0.6g混合均匀,再通过软胶囊主机控制下制备囊壳胶膜。 Put 80g of gelatin and 80g of water into a vacuum sol bucket, soak the gelatin for 40 minutes to swell, stir and dissolve at 80°C, then add 40g of glycerin, 0.2g of methyl p-hydroxybenzoate, and 0.6g of bright melanin and mix evenly. Then the capsule shell film is prepared under the control of the soft capsule host. the
利用软胶囊机制备玉米花丝软胶囊丸,定型18h后,浸于75%乙醇中洗丸10秒后取出,并在21℃晾丸,控制相对湿度为45%,晾至24h后,剔除软胶囊丸形不均匀、不饱满的即为玉米花丝软胶囊成品。 Use a soft capsule machine to prepare corn silk soft capsule pills. After setting the shape for 18 hours, wash the pills in 75% ethanol for 10 seconds, take them out, and dry the pills at 21°C. Control the relative humidity at 45%. After drying for 24 hours, remove the soft capsules The ones with uneven and unfull shape are the finished corn silk soft capsules. the
实施例2 Example 2
取干玉米花丝60g,剔除霉变部分,用水浸泡再流水冲洗反复操作4次,烘干至水分含量5%,粉碎至颗粒度200目;烘干时温度控制在60~70℃。 Take 60g of dried corn filaments, remove the mildewed parts, soak in water and rinse with running water for 4 times, dry to a moisture content of 5%, and crush to a particle size of 200 mesh; the drying temperature is controlled at 60-70°C. the
将10g蜂蜡在90℃融化,加入玉米花丝粉40g、植物油358g、维生素E 1g、维生素C 1g,在40℃搅拌使物料混合均匀,再经过胶体磨8次,40℃保温,得到软胶囊的囊化液。 Melt 10g of beeswax at 90°C, add 40g of corn silk powder, 358g of vegetable oil, 1g of vitamin E, and 1g of vitamin C, stir at 40°C to mix the materials evenly, and then pass through the colloid mill 8 times, keep warm at 40°C, and obtain the capsule of the soft capsule liquid. the
先将明胶100g和水200g投入至真空溶胶桶中,经30分钟的浸泡使明胶膨胀,在60℃下搅拌溶解,再加入甘油50g、亮黑色素0.4g、对羟基苯甲酸甲酯0.6g,混匀后再通过软胶囊主机控制下制备囊壳胶膜。 First put 100g of gelatin and 200g of water into the vacuum sol bucket, soak the gelatin for 30 minutes to swell, stir and dissolve at 60°C, then add 50g of glycerin, 0.4g of bright melanin, 0.6g of methyl p-hydroxybenzoate, mix After uniformity, the capsule shell film is prepared under the control of the soft capsule host. the
利用软胶囊机制备玉米花丝软胶囊丸,定型8h后,浸于95%乙醇中洗丸30秒后取出,并在25℃晾丸,控制相对湿度为35%,晾至10h后,剔除软胶囊丸形不均匀、不饱满的即为玉米花丝软胶囊成品。 Use a soft capsule machine to prepare corn silk soft capsule pills. After setting the shape for 8 hours, soak the pills in 95% ethanol for 30 seconds, take them out, and dry the pills at 25°C. Control the relative humidity at 35%. After airing for 10 hours, remove the soft capsules The ones with uneven and unfull shape are the finished corn silk soft capsules. the
实施例3 Example 3
取干玉米花丝100g,剔除霉变部分,用水浸泡再流水冲洗反复操作3次,选用湿料粉碎烘干,颗粒度控制在100目,烘干温度应该控制在60℃。 Take 100g of dried corn filaments, remove the moldy part, soak in water and rinse with running water for 3 times, use wet materials to crush and dry, the particle size should be controlled at 100 mesh, and the drying temperature should be controlled at 60°C. the
将20g蜂蜡在70℃融化,加入玉米花丝粉60g、植物油380g、维生素E 2g、维生素C 2.2g,在40℃搅拌使物料混合均匀,再经过胶体磨5次,40℃保温,得到软胶囊的囊化液。 Melt 20g of beeswax at 70°C, add 60g of corn silk powder, 380g of vegetable oil, 2g of vitamin E, and 2.2g of vitamin C, stir at 40°C to mix the materials evenly, then pass through the colloid mill for 5 times, keep warm at 40°C, and obtain the soft capsule cystic fluid. the
先将明胶50g和水120g投入至真空溶胶桶中,经5分钟的浸泡使明胶膨胀,在80℃下搅拌溶解,再加入甘油50g、棕黄色素0.2g、对羟基苯甲酸甲酯0.3g,混匀后再通过软胶囊主机控制下制备囊壳胶膜。 First put 50g of gelatin and 120g of water into the vacuum sol bucket, soak the gelatin for 5 minutes to swell, stir and dissolve at 80°C, then add 50g of glycerin, 0.2g of buffy yellow pigment, and 0.3g of methyl p-hydroxybenzoate. After mixing evenly, the capsule shell film is prepared under the control of the soft capsule host. the
利用软胶囊机制备玉米花丝软胶囊丸,定型12h后,浸于85%乙醇中洗丸 20秒后取出,并在23℃晾丸,控制相对湿度为40%,晾至12h后,剔除软胶囊丸形不均匀、不饱满的即为玉米花丝软胶囊成品。 Use a soft capsule machine to prepare corn silk soft capsule pills. After setting the shape for 12 hours, soak the pills in 85% ethanol for 20 seconds, take them out, and dry the pills at 23°C with a relative humidity of 40%. After airing for 12 hours, remove the soft capsules The ones with uneven and unfull shape are the finished corn silk soft capsules. the
实施例4 Example 4
取干玉米花丝200g,剔除霉变部分,用水浸泡再流水冲洗反复操作4次,选用湿料粉碎烘干,颗粒度控制在80目,烘干温度应该控制在80℃。 Take 200g of dried corn filaments, remove the moldy part, soak in water and rinse with running water for 4 times, use wet materials to crush and dry, the particle size should be controlled at 80 mesh, and the drying temperature should be controlled at 80°C. the
将100g蜂蜡在80℃融化,加入玉米花丝粉150g、植物油1200g、维生素E5g、维生素C4g,在20℃搅拌使物料混合均匀,再经过胶体磨10次,20℃保温,得到软胶囊的囊化液。 Melt 100g of beeswax at 80°C, add 150g of corn silk powder, 1200g of vegetable oil, 5g of vitamin E, and 4g of vitamin C, stir at 20°C to mix the materials evenly, then pass through the colloid mill for 10 times, keep warm at 20°C, and obtain the encapsulation liquid of the soft capsule . the
先将明胶100g和水200g投入至真空溶胶桶中,经20分钟的浸泡使明胶膨胀,在50℃下搅拌溶解,再加入甘油30g、棕黄色素0.9g、对羟基苯甲酸甲酯0.8g,混匀后再通过软胶囊主机控制下制备囊壳胶膜。 First put 100g of gelatin and 200g of water into the vacuum sol bucket, soak the gelatin for 20 minutes to swell, stir and dissolve at 50°C, then add 30g of glycerin, 0.9g of brown yellow pigment, and 0.8g of methyl p-hydroxybenzoate. After mixing evenly, the capsule shell film is prepared under the control of the soft capsule host. the
利用软胶囊机制备玉米花丝软胶囊丸,定型10h后,浸于95%乙醇中洗丸30秒后取出,并在25℃晾丸,控制相对湿度为45%,晾至10h后,剔除软胶囊丸形不均匀、不饱满的即为玉米花丝软胶囊成品。 Use a soft capsule machine to prepare corn silk soft capsule pills. After setting the shape for 10 hours, soak the pills in 95% ethanol for 30 seconds, take them out, and dry the pills at 25°C. Control the relative humidity at 45%. After airing for 10 hours, remove the soft capsules The ones with uneven and unfull shape are the finished corn silk soft capsules. the
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