General introduction
In some embodiments, provide the chewing gum composition that comprises first district and second district, described first district is the solid candy composition that comprises activating agent, and described second district comprises elastomer.
In some embodiments, described first district is anti-solid of chewing, as taffy, nougat, Fu Labei, the strange sugar of method or the like.
In some embodiments, described chewing gum composition is the form with piller, rod, ball, fragment, rope or herring bone, can also be circle, square, rectangle or trapeziform shape.
In other embodiments of the present invention, provide the chewing gum composition that comprises first district and second district, described first district comprises the solid central filler compositions that comprises active matter, and described second district comprises the elastomer adjacent to described first district.
Described second district can center on described first district fully.Further, described first district and second district can be distributed in the whole described chewing gum composition equably.Described center filler compositions can comprise that at least a active matter and one or more plant the composition of materials, described one or more plant materials and be selected from the group that, acesulfame potassium sweet by sweet taste material, flavor enhancement, sugar, high-fructose corn syrup, Abbas, gelatin, natural oil ﹠ fat are formed.In addition, described active matter can comprise caffeine.If desired, described first district can comprise anti-solid of chewing, and described anti-solid of chewing can be that the strange sugar of taffy, nougat, Fu Labei, method, infusion are sugared, the candy based on isomalt, particulate, powder, suspension, two or more are selected from any in the composition of the group of forming by anti-solid of chewing, infusion sugar, based on the candy and the particulate of isomalt.
In some embodiments, described first district can comprise solid suspension, and described solid suspension can comprise the particulate that is dispersed in the anti-solid of chewing.If desired, described particulate can be encapsulated, and can comprise by the particle of seasoning and/or increase sweet material.Described first district may further include coolant agent.Described first district can be partially filled or fully be filled.Described chewing gum composition can be various forms, comprises piller, rod, ball, sheet, fragment, rope, herring bone, square, rectangle or trapeziform form.Described composition may further include dressing.
In the present invention more again in other the embodiment, the method for making the chewing gum composition that solid central fills is provided, described method comprises step: the solid candy composition and the matrix sugar bodying agent that comprise active matter are provided; And described confectionery composition of coextrusion and described matrix sugar bodying agent, so that described solid candy composition is set within the described matrix sugar bodying agent.
In further embodiment of the present invention, the method for the chewing gum composition of making the solid central filling is provided, described method comprises step: at high temperature, confectionery composition is mixed with active matter to form the candy melt; Cool off described composition; Elastomer is provided; And described confectionery composition of coextrusion and elastomer, so that described confectionery composition is set within the described elastomer.Described method may further include the step that the chewing gum composition that the described solid candy center that is extruded is filled is cut into independent piece.
In other embodiments of the present invention, provide a dosage active matter is delivered to individual method, described method comprises step: the chewing gum that comprises solid central filler district is provided, and described solid central filler district comprises at least a active matter; Chew described matrix sugar; And with described active matter through port transmucosal and the two absorption of gastronintestinal system and enter in the individual whole body system.In some embodiments, described active matter can comprise caffeine.Described individuality can be chewed described chewing gum in any desired time span, and can chew described chewing gum at least 2 minutes.
More again in other the embodiment, provide the chewing gum composition that comprises first district and second district in the present invention, described first district comprises the solid central filler compositions, and described solid central filler compositions comprises sweet taste material and/or extender; At least a active matter; And local flavor thing; Described second district comprises elastomer.
In another embodiment, edible product external member (kit) is provided, described edible product external member comprises a plurality of edible of separating, described a plurality of edible is packaged, so that at least one first and one second is touched in the oral cavity basically simultaneously, wherein said first comprises the solid candy composition, and described solid candy composition comprises active matter, and described second comprises elastomer.
In other embodiments of the present invention, provide the method for making the chewing gum composition of filling at the solid candy center, described method comprises step: the solid candy that comprises active matter composition is provided; Elastomer is provided; And with described elastomer around described solid candy composition so that described solid candy composition is set within the described elastomer.In some embodiments, described active matter can comprise caffeine.
In other embodiments of the present invention, provide the method for the chewing gum composition of making the solid candy center filling that contains caffeine, described method comprises step: the solid candy that comprises at least a active matter composition is provided; Elastomer is provided; Described solid candy composition of coextrusion and described elastomer, thus described elastomer is around described solid candy composition; And the described composition that is extruded is cut into independent piece.In some embodiments, described active matter can comprise caffeine.
In other embodiment more of the present invention, provide and improve the individual notice and the method for absorbed force level, described method comprises step: the chewing gum that comprises the solid central fill area that contains caffeine is provided; Chew described chewing gum; With described caffeine through port transmucosal and the two absorption of gastronintestinal system and enter the whole body system of described individuality.In some embodiments, described individuality can be chewed described chewing gum at least 2 minutes.In other embodiment, the composition that described solid central is filled can be dispersed in whole described elastomer equably.
Described chewing gum composition may further include taste and shelters composition.The further embodiment of the present invention comprises having the chewing gum composition that taste is sheltered composition, described have taste and shelter the chewing gum composition of composition and comprise first district that comprises the solid candy composition and comprise elastomeric second district that described solid candy composition comprises active matter and fat.In some embodiments, described active matter can comprise caffeine.Described fat can exist with any desired amount, and exists with the amount from 1-15% of described first district's weight in one embodiment.In other embodiment, described fat exists with the amount from 0.5-10% of described chewing gum composition.
Further embodiment of the present invention comprises the method for sheltering the peculiar smell in the chewing gum, and described method comprises step: the solid candy composition that comprises active matter and fat is provided; Elastomer is provided; And with described elastomer around described solid candy composition so that described solid candy composition is set within the described elastomer.
Describe in detail
In some embodiments, chewing gum composition provide the active matter of a dosage (as caffeine) is delivered to as described in the chewing gum user, still keep it simultaneously and conform with the taste of expectation and the advantage of quality.
As used in this article, " comprise (comprising) " with the transitional term of " comprising (including) ", " comprising (containing) " or " it is characterized in that (characterized by) " synonym (also having comprises etc.), comprising property or opening, and do not get rid of key element or method step extra, not statement, the preamble or the main part that are used for claim with it are irrelevant.
As used in this article, term " type that froths matrix sugar (bubble gum) " and " chewing gum (chewing gum) " are used interchangeablely, and both's intention comprises any gum composition.
As used in this article, term " center filler " refers to the inner most district of described composition.Term " center filler " does not hint the symmetry of gum pieces, and just described " center filler " is in another district of gum pieces.In some embodiments, can there be center filler more than one.
As used in this article, term " solid candy composition " and " solid central filler compositions " refer to and do not flow freely, and the shape that can at room temperature keep it is up to the confectionery composition that applies external force thereon." solid " is not meant hard material or neither refers to not comprise the material of the air gap or other materials in composition.
Embodiment described herein provides the multi-region chewing gum composition, described multi-region chewing gum composition can comprise solid candy composition and the matrix sugar bodying agent that comprises caffeine, and described matrix sugar bodying agent is adjacent to described solid candy composition.In some embodiments, described confectionery composition can comprise the demixing zone of similar and different material.For example, described composition can comprise one or more chewing gum composition district, one or more solid candy composition district or its combination.In one embodiment, described composition can be flatly, vertically or diagonally with " sandwich " structure or side by side (side-by-side) structure by layering, all there is an outer surface in each district, and described outer surface is visible to small part by the user.
In one embodiment, described composition can comprise three or more to construct the layer of arranging side by side.In a specific embodiment, described composition can comprise first exterior layer of solid candy composition, the interior layer of chewing gum composition and second exterior layer of solid candy composition.In another embodiment, described composition can comprise first exterior layer of chewing gum composition, the interior layer of solid candy composition and second exterior layer of chewing gum composition.If desired, any desired structure can be merged in, and can comprise more than three layers or be less than three layers.Further, each district can be visible from the outside, and can comprise different colors or quality, so that the user can more easily distinguish different layers.Described different layer can form by any desired mode.For example, described layer can be so that structure be by coextrusion together side by side, and perhaps they can be configured after described district has formed.
Chewing gum composition
Described chewing gum composition can comprise matrix sugar bodying agent.Described matrix sugar bodying agent can comprise any known component in chewing gum field.These components can be water miscible, water-insoluble or its combination.For example, described matrix sugar bodying agent can comprise elastomer, extender, wax, elastomer solvent, emulsifying agent, plasticizer, filler and its mixture.
The elastomer (rubber) that adopts in matrix sugar bodying agent will depend on various factors and big change will be arranged, the denseness of the gum composition of matrix that described various factors is for example expected sugar bodying agent type, expectation and be used in other components in the described composition is to make the chewing gum final products.Described elastomer can be in any water-insoluble polymer known in the art, and comprises those the gummy polymer (gum polymer) that are used for chewing gum and froth type matrix sugar.The illustrative embodiment of the polymer that is fit in the matrix sugar bodying agent comprises natural and synthetic elastomer.For instance, those polymer that are suitable in matrix sugar bodying agent composition comprise, but be not limited to, (plant origin) natural materials, for example tunny gum, natural rubber, hat glue, red sandalwood glue, black apple glue, gelutong, tonka-bean natural gum, Niger's gutta-percha, Ka Sidela glue, balata, gutta-percha, Apocynaceae gumwood glue, sorva, gutta-percha (gutta kay) or the like with and composition thereof.Synthetic elastomeric embodiment include, but is not limited to SB (SBR), polyisobutene, isobutylene-isoprene copolymer, polyethylene, polyvinyl acetate or the like with and composition thereof.
The elastomeric amount that adopts in described matrix sugar bodying agent can depend on various factors and change, the denseness of the type of matrix that described factor is for example adopted sugar bodying agent, the gum composition of expectation and be used in other components in the said composition is to make the chewing gum final products.In general, described elastomer can desirably be present in the matrix sugar bodying agent from about 35% amount to about 40% weight with from about 10% to about 60% weight.
In some embodiments, described matrix sugar bodying agent can comprise wax or fat.Wax or fat can soften polymeric elastic body mixture, and improve the elasticity of described matrix sugar bodying agent.Wax that is adopted and/or fat can have about fusing point below 60 ℃ when existing, and described fusing point can drop between about 45 ℃ and about 55 ℃.In some embodiments, low-melting wax can be paraffin.Described fat and/or wax can with matrix sugar bodying agent weight from about 6% to about 10%, and amount that can from about 7% to about 9.5% is present in the matrix sugar bodying agent.Described matrix sugar bodying agent also can be no wax.
Except that described low melt wax, the wax with higher melt also can be used in the matrix sugar bodying agent with the amount up to about 5% of matrix sugar bodying agent weight.These high melting-point waxs comprise beeswax, vegetable wax, candelila wax, Brazil wax (carnubawax), most of pertroleum wax etc., and composition thereof.
Except that component set forth above, described matrix sugar bodying agent can comprise various other compositions, for example is selected from the component of elastomer solvent, emulsifying agent, plasticizer, filler and composition thereof.
Matrix sugar bodying agent can comprise elastomer solvent with auxiliary softening elastomeric component.Such elastomer solvent can comprise those elastomer solvents known in the art, for instance, terpinene resin (for example polymer of australene or nopinene), the methyl of rosin, glycerine and pentaerythritol ester and modified rosin, and for example hydrogenation, dimerization and rosin polymerization glue, and composition thereof.The embodiment that is applicable to elastomer solvent herein can comprise glyceride and the partially hydrogenated wood rosin and the gum rosin of glyceride, wood rosin and gum rosin of glyceride, the toll oil rosin of the wood rosin of glyceride, polymerization of the wood rosin of glyceride, part dimerization of pentaerythritol ester, the wood rosin of pentaerythritol ester, wood rosin and the gum rosin of partially hydrogenated wood rosin and gum rosin and gum rosin and gum rosin, and the partially hydrogenated methyl esters of wood rosin and gum rosin (wood and rosin) etc., and composition thereof.Elastomer solvent can with matrix sugar bodying agent weight from about 2% to about 15%, and amount that can from about 7% to about 11% is used for matrix sugar bodying agent.
Matrix sugar bodying agent can also comprise that emulsifying agent is distributed to immiscible component in the single stable system with auxiliary.Useful emulsifying agent comprises glycerin monostearate, lecithin, glycerine monofatty ester, two glyceride, propylene glycolmonostearate etc. among the present invention, and composition thereof.Described emulsifying agent can with matrix sugar bodying agent weight from about 2% to about 15%, and more specifically from about 7% to about 11% amount is used.
Matrix sugar bodying agent can also comprise plasticizer or quality and the denseness character of softening agent so that various expectations to be provided.Because the low-molecular-weight of these compositions, plasticizer and softening agent can penetrate the foundation structure of (penetrate) matrix sugar bodying agent, make described matrix sugar bodying agent become plastic and viscous more not.Useful plasticizer and softening agent comprise lanolin, palmitic acid, oleic acid, stearic acid, odium stearate, potassium stearate, triacetyl glycerine, glycerine lecithin (glyceryl lecithin), glycerin monostearate, propylene glycolmonostearate, acetylated monoglyceride, glycerine etc., and composition thereof.Wax also can be merged in the matrix sugar bodying agent, for example natural and synthetic wax of described wax, hydrogenated vegetable oil, pertroleum wax (for example polyurethane wax), Tissuemat E, paraffin, microwax, fatty wax (fatty wax), sorbitan monostearate, tallow, propane diols and composition thereof etc.Described plasticizer and softening agent usually with matrix sugar bodying agent weight up to about 20% amount, and more specifically be used to the matrix sugar bodying agent with from about 9% to about 17% amount of matrix sugar bodying agent weight.
Plasticizer also comprises hydrogenated vegetable oil, is for example adopted or make up the soya-bean oil and the cottonseed oil of employing separately.These plasticizer provide good quality and soft chew characteristics for matrix sugar bodying agent.These plasticizer and softening agent usually with matrix sugar bodying agent weight from about 5% to about 14%, and more specifically be used with from about 5% to about 13.5% amount of matrix sugar bodying agent weight.
The glycerine that comprises anhydrous glycerol also can be used as softening reagent employing, for example commercially available American Pharmacopeia of described glycerine (USP) level.Glycerine is the precursor syrup solution with sweet warm taste, and the sugariness that has is about 60% of a sucrose sweetness.Because glycerine is moisture absorption, in the whole process of preparation of described chewing gum composition, anhydrous glycerol can be maintained under the anhydrous condition.
In some embodiments, described matrix sugar bodying agent can also comprise the extender of effective dose, for example can serve as the mineral assistant (mineral adjuvant) of filler and quality improver (textural agent).Useful mineral assistant comprises calcium carbonate, magnesium carbonate, aluminium oxide, aluminium hydroxide, alumina silicate, talcum, tricalcium phosphate, Dicalcium Phosphate, calcium sulfate etc., and composition thereof.These fillers or assistant can be used in the described matrix sugar bodying agent composition with various amounts.When being used, the amount of described filler can with described matrix sugar bodying agent weight from about 15% to about 40%, and amount that can from about 20% to about 30% exists.
In described matrix sugar bodying agent, can comprise various traditional compositions with effective dose alternatively, for example flavouring agent and colouring agent, antioxidant, anticorrisive agent (preservative) etc.For instance, can utilize the titanium dioxide and other dyestuffs that are suitable for food, medicine and cosmetic applications (to be called as F.D.﹠amp; The C dyestuff).Can also comprise antioxidant, for example dibutyl hydroxy toluene (BHT), butylated hydroxy anisole (BHA), n-propyl gallate, vitamin E, and composition thereof.In described matrix sugar bodying agent, can also adopt other known conventional chewing gum sugar additives of chewing gum field those of ordinary skill.
Described chewing gum composition can comprise the additive of the routine of a tittle, and described additive is selected from by increasing the group that sweet reagent, plasticizer, softening agent, emulsifying agent, wax, filler, extender (carrier, extension agent, increment sweet taste material), mineral assistant, flavouring agent and staining reagent, antioxidant, acidulant, thickener, medicament, oral care actives or the like and composition thereof are formed.Described oral care actives, for example remineralizing agent, antimicrobial agents and brightener for tooth, (as the Application No. 10/901 of the common pending trial of assignee submitted on July 29th, 2004,511, be entitled as described in the patent of " Tooth Whitening Composition and Delivery Systems Thereof (dental whitening compositions and delivery system thereof) ", described patent is incorporated into this paper by integral body by reference).In these additives some can have more than one purposes.For example, in the sugar-free gum composition, sweet taste material such as maltitol or other sugar alcohols also can be used as extender and work.
Increment sweet taste material package is drawn together increment sweet taste material that contains sugar, sugar-free or the like, or its mixture.Increment sweet taste material exists with about 5% to about 99% amount of described chewing gum composition weight usually.
The suitable sugared sweet taste material that contains generally includes list-saccharide, two-saccharide and many-saccharide, for example (but being not limited to) sucrose (sugar), dextrose (dextrose), maltose, glucan, wood sugar, ribose, glucose, lactose, mannose, galactolipin, fructose (levulose (levulose)), invert sugar, FOS (fructo oligo saccharide) syrup, the starch of partial hydrolysis, sucromalt, corn syrup solids, isomaltoketose, and composition thereof.
The increment sweet taste material package of suitable sugar-free is drawn together sugar alcohol (or polyalcohol), the glucidtemns of the isomaltoketose (ISOMALT) of (but being not limited to) D-sorbite, xylitol, mannitol, galactitol, maltitol, hydrogenation, lactitol, antierythrite, hydrogenation for example, and composition thereof.
Suitable hydrogenated starch hydrolysate comprises that those are at U.S. Patent number 4, disclosed hydrogenated starch hydrolysate and the various hydrogenated glucose syrups and/or the powder that comprise D-sorbite, maltitol, hydrogenation dimerization saccharide, the senior poly saccharide of hydrogenation or its mixture in 279,931.Hydrogenated starch hydrolysate mainly prepares by the controlled catalytic hydrogenation to corn syrup.The hydrogenated starch hydrolysate of gained is mixture monomer, dimerization and saccharide poly.The ratio of the saccharide that these are different gives different hydrogenated starch hydrolysates different character.The mixture of hydrogenated starch hydrolysate also is useful, and the mixture of described hydrogenated starch hydrolysate is for example that produce by French Roquette Freres, commercially available product LYCASIN
With the SPI Polyols by Delaware State New Castle, Inc. is that produce, commercially available product HYSTAR
In some embodiments, high strength sweet taste material also can be used as sweetener and is included in the composition.Be not limited to specific sweet taste material, representational classification and embodiment comprise:
(a) water miscible sweetener, dihydrochalcone for example, not interior albumen, stevioside and stevia rebaudianum derived compounds, such as but not limited to Lai Baodi glycosides A (rebaudiocide A), different (iso-) momordica grosvenori glycoside V etc., Momordica grosvenori (lo han quo) and Momordica grosvenori derived compounds, glycyrrhizin, dihydroriboflavin, and sugar alcohol, D-sorbite for example, mannitol, maltitol, xylitol, antierythrite, and as U.S. Patent number 4,619, the amino chain acid ester acid amides of disclosed L-diamino dicarboxylic acid in 834, and composition thereof, the disclosure of above-mentioned patent is merged in this paper by reference;
(b) water-soluble artificial sweetening, for example soluble saccharin salt, i.e. the saccharin salt of sodium or calcium, cyclohexyl-n-sulfonate, 3,4-dihydro-6-methyl isophthalic acid, 2,3-Evil thiazine-4-ketone-2, the sodium salt of 2-dioxide, ammonium salt or calcium salt, 3,4-dihydro-6-methyl isophthalic acid, 2,3-Evil thiazine-4-ketone-2, and the sylvite of 2-dioxide (acesulfame potassium, Acesulfame-K), the free acid form of asccharin and composition thereof;
(c) based on the sweet taste material of dipeptides, for example from the aspartate-derived sweet taste material of L-, L-aspartyl-L-phenylalanine methyl esters (Aspartame) for example, N-[N-(3, the 3-dimethylbutyl)-L-α-aspartoyl]-L-phenylalanine 1-methyl esters (knob is sweet), and U.S. Patent No. 3,492, the material of describing in 131, L-α-aspartoyl-N-(2,2,4,4-tetramethyl-3-vulcanizes trimethylene)-D-alanimamides hydrate (alitame), L-aspartoyl-L-phenyl glycerine and L-aspartoyl-L-2, the methyl esters of 5-dihydro phenyl-glycine, L-aspartoyl-2,5-dihydro-L-phenylalanine; L-aspartoyl-L-(1-cyclohexene)-alanine and composition thereof;
(d) the water-soluble sweet taste material of deriving from naturally occurring water-soluble sweet taste material, the chlorinated derivatives of for example common sugar (sucrose), for example chloride deoxy sugar derivative (for example, for instance, with known name of product Sucralose or Splenda
TMChlorination deoxidation sucrose or the derivative of chlorination deoxidation sucralose); The embodiment of the derivative of chlorination deoxidation sucrose and chlorination deoxidation sucralose includes, but is not limited to: 1-chloro-1 '-deoxidation sucrose; 4-chloro-4-deoxidation-α-D-galactopyranose base-α-D-fructofuranoside, or 4-chloro-4-deoxidation sucralose; 4-chloro-4-deoxidation-α-D-galactopyranose base-1-chloro-1-deoxidation-β-D-fructose-furanoside, or 4,1 '-two chloro-4,1 '-the dideoxy sucralose; 1 ', 6 '-dichloro 1 ', 6 '-dideoxy sucrose; 4-chloro-4-deoxidation-α-D-galactopyranose base-1,6-two chloro-1,6-dideoxy-beta-D-fructofuranose glycosides, or 4,1 ', 6 '-three chloro-4,1 ', 6 '-three deoxidation sucralose; 4,6-two chloro-4,6-dideoxy-α-D-galactopyranose base-6-chloro-6-deoxidation-beta-D-fructofuranose glycosides, or 4,6,6 '-three chloro-, 4,6,6 '-three deoxidation sucralose; 6,1 ', 6 '-three chloro-6,1 ', 6 '-three deoxidation sucrose; 4,6-two chloro-4,6-dideoxy-α-D-gala-pyrans glycosyl-1,6-two chloro-1,6-dideoxy-beta-D-fructofuranose glycosides, or 4,6,1 ', 6 '-tetrachloro 4,6,1 ', 6 '-four deoxy-galactoses-sucrose; And 4,6,1 ', 6 '-four deoxidations-sucrose, and composition thereof;
(e) based on the sweet taste material of protein, for example the derivative of the extract of miraculin (miraculin), Synseplum dulcificum and extract, caper seed (mabinlin), curculin (curculin), in albumen, Bu Nazhen (brazzein), spray tower spit of fland (pentadin), the extract of Pentadiplandra brazzeana and the derivative of extract, Suo Matian, thaumati (thaumaoccous danielli) (sweet I of rope horse and II) and Tallin (talin);
(f) sweet taste material Mo Nating (monatin) (2-hydroxyl-2-(indol-3-yl methyl)-4-aminoglutaric acid) and derivative or isomers; And
(g) sweet taste material Momordica grosvenori (Lo han guo) (being also sometimes referred to as " Lo han kuo ").
Intense sweetener can be used with the physical form of many uniquenesses well known in the art, so that the initial prominent sweet feel of releasing (burst) and/or prolonging of sweet taste to be provided.Such physical form includes but not limited to the form of multiple free form, spray-dried forms, powdery form, pearl, entrapped form, and composition thereof.In one embodiment, described sweet taste material is a high strength sweet taste material, for example Aspartame, Sucralose and acesulfame potassium (for example, Ace-K or acesulfame-K).
In some embodiments, described sweet taste material can be a polyalcohol.Polyalcohol can include, but is not limited to glycerine, D-sorbite, maltitol, maltitol syrup, mannitol, isomalt, antierythrite, xylitol, hydrogenated starch hydrolysate, polydextrose alcohol (polyglycitol) syrup, polydextrose alcohol powder, lactitol with and combination.
Described sweet taste material can be the part of delivery system, and can use with the essential amount that gives sugariness.Usually, the powerful sweet taste material of effective dose can be utilized to provide the sweetness level of expectation, and this amount can change with selected sweet taste material.Described powerful sweet taste material can exist with from about 0.001% to about 3% amount of described chewing gum composition weight, depends on the combination of employed sweet taste material or sweet taste material.The definite scope of the amount of the sweet taste material of each type can be selected by those skilled in the art.
Local flavor thing (flavoring or flavouring agent) can be used in the described chewing gum composition.Described local flavor thing comprises the local flavor thing that those those of skill in the art are known, for example natural and artificial local flavor thing.These flavorings can be selected from synthetic local flavor oil and seasoning fragrance product and/or oil, the extract of oleoresin and plant-derived, leaf, flower, fruit or the like with and make up.Non-limiting representative local flavor oil comprises spearmint oil, cinnamon oil, wintergreen (gaultherolin), mentha piperita oil, Japanese peppermint oil, caryophyllus oil, oreodaphene, aniseed oil, eucalyptus oil, thyme linaloe oil, cedar leaves oil, mace oil, allspice, sage oil, mace (mace), almond oil and cassia oil.Same useful flavoring is artificial, natural and synthetic fruit-like flavour thing, as vanilla, and tangerine oil (comprising lemon, orange, bitter orange, grape fruit, yazu, sour tangerine), and fruit essence (comprising apple, pears, peach, grape, blueberry, strawberry, raspberry, cherry, plum, pineapple, watermelon, apricot, banana, muskmelon, apricot, plum, cherry, raspberry, blackberry, blueberry, torrid zone fruit, mango, mangosteen, pomegranate, pawpaw or the like).Other potential local flavor things comprise newborn local flavor thing, butter local flavor thing, cheesy flavor thing, cream local flavor thing and sour milk local flavor thing; The vanilla flavor thing; Tea or coffee local flavor thing is as green tea local flavor thing, oolong tea local flavor thing, tea local flavor thing, cocoa local flavor thing, chocolate flavouring thing and coffee flavor thing; Peppermint local flavor thing is as American mint local flavor thing, spearmint local flavor thing and cornmint local flavor thing; Pungent local flavor thing is as asafoetide local flavor thing, ajowan (ajowan) local flavor thing, anise local flavor thing, Radix Angelicae Sinensis local flavor thing, the fennel taste thing, allspice local flavor thing, Chinese cassia tree local flavor thing, camomile local flavor thing, mustard local flavor thing, cardamom local flavor thing, caraway local flavor thing, cumin local flavor thing, cloves local flavor thing, pepper local flavor thing, coriander local flavor thing, yellow camphor tree local flavor thing, savoury local flavor thing, Chinese prickly ash local flavor thing, purple perilla local flavor thing, gin local flavor thing, the flavor compounds in ginger thing, anistree local flavor thing, horseradish local flavor thing, thyme local flavor thing, tarragon local flavor thing, dill local flavor thing, capsicum local flavor thing, nutmeg local flavor thing, sweet basil local flavor thing, marjoram local flavor thing, rosemary, local flavor thing, basyleave local flavor thing and horseradish (wasabi) (Japanese horseradish) local flavor thing; Drinks local flavor thing, for example fruit wine flavor thing, whiskey local flavor thing, brandy local flavor thing, Rum local flavor thing, gin local flavor thing and ligueur local flavor thing; Flowers local flavor thing; With the vegetable flavor thing, as onion local flavor thing, garlic flavor thing, cabbage local flavor thing, carrot local flavor thing, celery local flavor thing, mushroom flavor thing and tomato flavor thing.These flavor enhancements can use with the liquid or solid form, and can use separately or with the form of mixture.Local flavor thing commonly used comprises pennyroyal, the American mint, menthol, spearmint, artificial vanilla, cinnamon derivative and the various fruit-like flavour thing that adopt as the form with independent or mixture.The local flavor thing can also provide the breath freshening characteristic, especially the peppermint local flavor thing when being used in combination with coolant agent.
The flavoring that other are useful comprises aldehydes and ester class, as cinnamyl acetate, cinnamic acid, citral diethyl acetal, acetic acid dihydro carvyl, formic acid cloves phenolic ester, right-methyl anisole (p-methylamisol) or the like.In general can use any as by flavoring or food additives described in " Chemicals Used in Food Processing (chemicals that uses in the food processing) " (publication 1274, the 63-258 page or leaf) of NAS.Described publication is merged in this paper by reference.
Further the embodiment of aldehydes flavoring includes, but is not limited to: acetaldehyde (apple), benzaldehyde (cherry, almond), anisic aldehyde (Radix Glycyrrhizae, anise), cinnamic acid (Chinese cassia tree), citral, it also is α-citral (lemon, bitter orange), neral, it also is neral (lemon, bitter orange), capraldehyde (orange, lemon), ethyl vanillin (vanilla, butterfat), the perfume flower, it also is piperonal (vanilla, butterfat), vanillic aldehyde (vanilla, butterfat), jasminal (the fruity local flavor thing that fragrant hot flavor is arranged), butyraldehyde (butter, cheese), valeral (butter, cheese), citronellal (modified product, polytype), capraldehyde (citrus fruit), aldehyde C-8 (citrus fruit), aldehyde C-9 (citrus fruit), aldehyde C-12 (citrus fruit), 2-ethyl butyraldehyde (berry fruits), hexenoic aldehyde, also promptly anti--2 (berry fruits), tolyl aldehyde (cherry, almond), veratraldehyde (vanilla), 2,6-dimethyl-5-heptenal, also be melonal (muskmelon), 2,6-dimethyl octanal (unripe fruit), and 2-laurylene aldehyde (citrus fruit, tangerine), cherry, grape, strawberry fruit juice jelly (shortcake), and composition thereof.
In some embodiments, described flavouring agent can be used with the form and/or the dry form of liquid.When later a kind of form is used, can use suitable drying mode, for example the described oil of spray-drying.Replacedly, described flavouring agent can be absorbed on the water-soluble material (for example cellulose, starch, sugar, maltodextrin, gum arabic etc.), perhaps can be encapsulated.The actual techniques of this dried forms of described preparation is well-known.
In some embodiments, described flavouring agent can be used with the physical form of many uniquenesses well known in the art, so that the initial prominent local flavor sense of releasing (burst) and/or prolonging of local flavor to be provided.This type of physical form includes but not limited to multiple free form, for example spray-dired, pulverous, the form of pearl, entrapped form, and composition thereof.
In chewing gum composition, flavouring agent usually with described composition weight from about 0.02% to about 5%, and more specifically from about 0.1% to about 4%, and even more specifically from about 0.8% to about 3% amount exist.
In some embodiments, described flavouring agent can be used with the physical form of many uniquenesses well known in the art, so that the initial prominent local flavor sense of releasing and/or prolonging of local flavor to be provided.This type of physical form includes but not limited to multiple free form, for example spray-dired, pulverous, the form of pearl, entrapped form, and composition thereof.
Provide the compound of tart flavour can comprise acidulant, for example acetate, adipic acid, ascorbic acid, butyric acid, citric acid, formic acid, fumaric acid, gluconic acid (glyconic acid), lactic acid, phosphoric acid, malic acid, oxalic acid, butanedioic acid, tartaric acid, and composition thereof.
Provide the compound of delicate flavour (umami) or delicious food (savory flavor) can comprise GLU list sodium (MSG), glutamic acid, glutamate, aspartate, free amino acid, IMP (disodium 5 '-inosine list phosphoric acid) and GMP (disodium 5 '-guanosine monophosphate), stimulate compound, mushroom flavor thing, fermented fish local flavor thing and the muscle local flavor thing (as beef, chicken, pork, ostrich meat, venison and buffalo meat) of T1R1 and T1R3 acceptor.
The material that gives pure and honest flavor (kokumi) can comprise and is selected from (1) gelatin and tropomyosin and/or tropomyosin peptide; (2) gelatin and paramyosinogen; And the mixture of (3) troponin and tropomyosin and/or tropomyosin peptide, the above-mentioned material of mentioning is as disclosed in the U.S. Patent number 5,679,397 of authorizing people such as Kuroda.
Provide the compound of saline taste can comprise common salt, as sodium chloride, calcium chloride, potassium chloride, 1-lysine and combination thereof.
Can adopt colouring agent with the amount of effective generation desired color.Described colouring agent can comprise pigment, and described pigment can be incorporated into about 6% amount up to described composition weight.For instance, titanium dioxide can be incorporated into about 2% amount up to described composition weight, and can be less than about 1%.Colorant can also comprise natural food colour and be applicable to the dyestuff of food, medicine and cosmetic applications.These colorants are called as F.D.﹠amp; C dyestuff and color lake.Acceptable material can be for water miscible in the aforementioned applications.Illustrative non-limiting example comprises and is called as F.D.﹠amp; C. blue No. 2 indigoid dye, it is 5, the disodium salt of 5-indigo disulfonic acid.Similarly, be called as F.D.﹠amp; C. green No. 1 dyestuff comprises triphenhlmethane dye, and is 4-[4-(N-ethyl-p-sulfonium benzylamino) diphenyl methylene]-single sodium salt of [1-(N-ethyl-N-p-sulfonium benzyl)-δ-2,5-cyclohexadiene imines].All F.D.﹠amp; C. the chemical constitution of the complete narration of colorant and their correspondences can be at Kirk-Othmer Encyclopedia of Chemical Technology (chemical technology encyclopaedia), the third edition, the 5th volume finds in the 857-884 page or leaf, and this text is merged in this paper by reference.
In some embodiments, described chewing gum composition can comprise realizable compound.Described realizable compound can comprise coolant agent, the agent of warm flavor, fiber crops thorn agent, effervescent agent and combination thereof.
Various known coolant agents can be used.For instance, in useful coolant agent, comprise xylitol, antierythrite, dextrose, D-sorbite, terpane, menthones, ketal, the menthones acetal, the peppermint glycerol ketals, replace the p-terpane, acyclic carboxamides, the thin lotus alcohol ester of glutaric acid, the Cyclohexamide that replaces, the hexamethylene formamide that replaces, the urea and the sulfanilamide (SN) that replace, the menthol that replaces, the hydroxymethyl derivative of methylol p-terpane and p-terpane, 2-sulfydryl-ring-decanone, hydroxycarboxylic acid with 2-6 carbon atom, Cyclohexamide, menthyl acetate, menthyl salicylate, N, 2,3-trimethyl-2-isopropyl butyramide (WS-23), N-ethyl-p-terpane-3-carboxylic acid amides (WS-3), N-[[5-methyl-2-(1-Methylethyl) cyclohexyl] carbonyl] glycine ethyl ester (WS5) and at the U.S. Patent number 7 of authorizing people such as Erman, 189, disclosed pure basically N-[[5-methyl-2-(1-Methylethyl) cyclohexyl in 760] carbonyl] ethyl ester (described patent is incorporated into this paper by integral body by reference) of glycine, isopulegol, peppermint oxygen base propane diols, 3-(1-peppermint oxygen base) the third-1, the 2-glycol, 3-(1-peppermint oxygen base)-2-methyl-prop-1, the 2-glycol, p-terpane-2, the 3-glycol, p-terpane-3, the 8-glycol, 6-isopropyl-9-methyl isophthalic acid, 4-dioxo spiro [4,5] decane-2-menthol, the butanedioic acid menthyl ester with and alkali salt, cyclonol, N-ethyl-2-isopropyl-5-hexahydrotoluene carboxylic acid amides, Japanese peppermint oil, mentha piperita oil, 3-(1-peppermint oxygen base) second-1-alcohol, 3-(1-peppermint oxygen base) third-1-alcohol, 3-(1-peppermint oxygen base) fourth-1-alcohol, 1-menthyl acetic acid N-acetamide, 1-menthyl-4-hydroxyl valerate, 1-menthyl-3-butyric ester, N, 2,3-trimethyl-2-(1-Methylethyl)-butyramide, n-ethyl-t-2-c-6 nonadiene acid amides, N, N-dimethyl menthyl succinamide, the p-terpane that replaces, the p-menthane carboxamides that replaces, 2-isopropyl-5-methyl ring ethanol (, after this being called " isopregol " from Hisamitsu Pharmaceuticals); Peppermint glycerol ketals (FEMA3807, trade name FRESCOLAT

The MGA type); 3-1-peppermint oxygen base the third-1,2-glycol (from Takasago, FEMA 3784); And menthyl lactate is (from Haarman﹠amp; Reimer, FEMA 3784, trade name FRESCOLAT
The ML type); WS-30, WS-14, eucalyptus extracts (p-menthyl-3,8 glycol), menthol (its natural or synthesis of derivatives), menthol PG carbonic ester, menthol EG carbonic ester, menthol glycerin ether, the N-tert-butyl group-p-terpane-3-carboxylic acid amides, P-terpane-3-short and long-chain acyl triglyceride molecules, methyl-2-isopropyl (isopryl)-two ring (2.2.1), heptane-2-carboxylic acid amides; Menthol methyl ether, menthyl 2-pyrrolidone-5-carboxylic acid ester; 2,5-dimethyl-4-(1-pyrrolidinyl)-3 (2H)-furanones; Ring-type alpha-keto-enamine, methyl cyclopentenyl ketone (cyclotene) derivative, cyclopentene class for example, comprise 3-methyl-2-(1-pyrrolidinyl)-2-cyclopentene-1-ketone and 5-methyl-2-(1-pyrrolidinyl)-2-cyclopentene-1-ketone, have the compound of following chemical formula:
Wherein B is selected from H, CH3, C2H5, OCH3,0C2H5; And OH; And wherein A is the part of general formula-CO-D, wherein D is selected from following part: (i)-and NR1R2, wherein R1 and R2 are independently selected from aliphatic series, alkoxyalkyl, hydroxy alkyl, araliphatic and the group of naphthene base of H and C1-C8 straight or branched, and perhaps the nitrogen-atoms that is connected of R1 and R2 and they forms the part of five or a hexa-member heterocycle that replaces alternatively together; (ii)-NIICH2COOCH2CH3 ,-NHCH2CONH2 ,-NHCH2CH2OCH3 ,-NHCH2CH2OH ,-NHCH2CH (OH) CH2OH and the part that (iii) is selected from the group of forming by following radicals:
Above-mentioned group and other are as disclosed in people's such as Bell PCT patent application WO2006/125334, and this PCT patent application is incorporated into this paper by integral body by reference.Other compounds are included in disclosed alpha-keto-enamine in the U.S. Patent number 6,592,884 of authorizing people such as Hofann, and this patent is incorporated into this paper by integral body by reference.These and other suitable coolant agent is further described in following United States Patent (USP), and all these patents are incorporated into this paper by integral body by reference: United States Patent (USP) 4,230,688,4,032,661,4,459,425,4,178,459,4,296,255,4,136,163,5,009,893,5,266,592,5,698,181,6,277,385,6,627,233,7,030,273.Other suitable coolant agent is further described in following U.S. Patent application 2005/0222256,2005/0265930 more again, and all these applications are incorporated into this paper by integral body by reference.
Some embodiments can comprise the agent of warm flavor, and described warm flavor agent can be selected from the compound of broad variety, and known being used for of these compounds provides warm sensory signal to individual user.These compounds give warm perception sensation (particularly in the oral cavity), and usually strengthen the impression of local flavor thing, sweet taste material and other organoleptic ingredients.Useful warm flavor agent comprises those with at least one pi-allyl vinyl component, and described pi-allyl vinyl component can be incorporated into the oral cavity acceptor.The embodiment of suitable warm flavor agent includes but not limited to: vanillic alcohol n-butyl ether (TK-1000 is by the supply of Tokyo TakasagoPerfumary Co., Ltd), the vanillic alcohol positive propyl ether, the vanillic alcohol isopropyl ether, the vanillic alcohol isobutyl ether, vanillic alcohol-n-amino ethers, the vanillic alcohol isoamyl ether, the vanillic alcohol n-hexyl ether, the vanillic alcohol methyl ether, the vanillic alcohol ether, zingiberol, salad oil, zingiberone phenol, zingerone, capsaicine, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, homodihydrocapsaicin, ethanol, isopropyl alcohol, isoamyl alcohol, phenmethylol, glycerine, chloroform, eugenol, cinnamon oil, cinnamic acid, its phosphate derivative and combination thereof.
The agent of fiber crops thorn can be utilized for the user fiber crops thorn flavor, sensation acupuncture or that make people's numbness are provided.The agent of fiber crops thorn includes but not limited to: golden button (jambu) oleoresin or golden button (para cress) (Spilanthes), and wherein active component is an affinin; Japan's Chinese pepper extract (Chinese prickly ash, Zanthoxylum peperitum) comprises being known as sanshool-I the composition of sanshool-II and sanshoamide (Sanshoamide); Perillartine (perillartine); 4-(1-peppermint oxygen ylmethyl)-2-phenyl-1, the 3-dioxolanes; Fructus piperis nigrum extract (pepper, piper nigrum) comprises active component chavicine and pipering; Echinacea (Echinacea) extract; The suterberry extract; Trans-pellitorine (trans-pellitorin) and hot red pepper oil resin.In some embodiments, can comprise from alkane acid amides such as the material extraction of golden button or Chinese pepper.In addition, in some embodiments, feel to cause by effervesce.This effervesce causes by combination basic matterial and acid material, both one of or the both can be encapsulated.In some embodiments, basic matterial can comprise alkali carbonate, alkali metal hydrogencarbonate, alkaline earth metal carbonate, alkali metal bicarbonates and composition thereof.In some embodiments, acid material can comprise acetic acid, adipic acid, ascorbic acid, butyric acid, citric acid, formic acid, fumaric acid, gluconic acid, lactic acid, phosphoric acid, malic acid, oxalic acid, butanedioic acid, tartaric acid and combination thereof." fiber crops thorn " but the embodiment of the sense of type is included in U.S. Patent number 6,780, those disclosed in 443,6,159,509,5,545,424 and 5,407,665, each described patent is included as a whole in this article by reference.
The oral cavity nursing agent that can be used comprises those active matters known to the skilled.Described active matter, for example (but being not limited to) surfactant, flavorants, antimicrobial, antiseptic, anticalculus agent, ascoxal, oral peculiar smell controlling agent, fluorine compounds, quaternary ammonium compound, remineralizing agent and combination thereof.Described gum composition may further include stimulus, activating agent or medicament.
Plasticizer discussed above, softening agent, mineral assistant, wax and antioxidant owing to be suitable for, also can be used for described chewing gum composition in described matrix sugar bodying agent.The embodiment of other operable conventional additives, comprise emulsifying agent, for example lecithin and glyceryl monostearate, adopt or combine the thickener of employing separately with other softening agents, (for example methylcellulose, alginate, carrageenan, xanthans, gelatin, angle beans (carob), tragacanth, locust bean gum and carboxymethyl cellulose), acidulant (for example malic acid, adipic acid, citric acid, tartaric acid, fumaric acid and composition thereof), and filler, (for example above those that under the classification of mineral assistant, discussed).
Other conventional matrix sugar additives that chewing gum field those of ordinary skill is known also can be used for described chewing gum composition.
Some embodiments expand to the method for preparing chewing gum products.Described product can prepare with standard technique well known by persons skilled in the art and equipment, the technology of described method generally comprises: melt described matrix sugar bodying agent, when mixing and batch of material is molded into independent chewing gum sugar, incorporate the composition of expectation into.Comprise chewing gum manufacturing known mixing in field and heater according to the useful device of embodiment described herein, and therefore the selection of described concrete device is obvious for the technical staff.For general chewing gum preparation technology, referring to the U.S. Patent number 4 of authorizing people such as Hopkins, 271,197, authorize people's such as Cherukuri U.S. Patent number 4,352,822 and authorize people's such as Cherukuri U.S. Patent number 4,497,832, each patent is incorporated into this paper by integral body by reference.
Independent chewing gum sugar can come moulding with the known standard technique in chewing gum field.For instance, the chewing gum sugar can prepare with sheet, piller, rod, center filler matrix sugar, rope, herring bone, fragment, ball, square, rectangle, irregular quadrilateral, (deposited) of cast, chewing gum or any other suitable form of compression.Filler district, center and chewing gum district can be combined together with any suitable method.For example, described two districts can be mixed together and become single agent.Alternately, described chewing gum district and candy district can form on basis side by side, or a district falls another inside, district.In one embodiment, described chewing gum district is around described solid candy district, but the present invention can expect other formation methods.Another embodiment comprises described solid candy composition and chewing gum, and described solid candy composition and chewing gum exist with the edible form of separating, and is packaged in together, and wherein, two pieces can both be chewed by the user simultaneously.
Described chewing gum composition can be the matrix sugar form of compression, for example, for instance, compressed tablets matrix sugar.Such embodiment can comprise the chewing gum bodying agent of particulate, and described embodiment can comprise compressible matrix sugar bodying agent composition and compressing tablet powder.The U.S. Provisional Patent Application of the common pending trial of assignee that the embodiment of the chewing gum of compression can submit on November 8th, 2005 number 60/734,680, be entitled as in the patent document of " Compressible Gum System (compressible matrix sugar system) " and find.
In some embodiments, described chewing gum composition can have the 3rd district.Described the 3rd district can form an outer surface on described chewing gum composition.When described the 3rd district formed outer surface, described the 3rd district can be known as dressing or dressing district.This chewing gum that is coated is commonly referred to as pellets matrix sugar.Described outside dressing can be hard or crisp.Any suitable coating material well known by persons skilled in the art can be used.Typically, described outer coatings can comprise D-sorbite, maltitol, xylitol, isomalt, antierythrite and other crystallizable polyalcohols; Also can adopt sucrose.In addition, described dressing can comprise several opaque layers, so that described chewing gum composition is invisible by dressing itself, described dressing can be covered by one or more other hyaline layer alternatively for the purpose of aesthetics, quality and protection.Described outer coatings can also comprise a spot of water and gum arabic.Described dressing can also further be coated by wax.Described dressing can be used by using dressing solution continuously in the mode of routine, wherein carries out drying between every layer of dressing.Along with the drying of dressing, it usually becomes opaque and usually is white, but can add other colorants.The polyalcohol dressing can further be coated by wax.Described dressing may further include colored thin slice or spot.If described composition comprises dressing, may in whole dressing, disperse one or more to plant active matter.If one or more another kinds of planting in active matter and the described active matter are incompatible in single-phase composite, this structure can be useful.Local flavor thing or realizable material can also be added in the described dressing with the further product feature that produces uniqueness.
Other materials may be added to described dressing to obtain the character of expectation.These materials can not add restrictedly and comprise, cellulosic (for example carboxymethyl cellulose), gelatin, xanthans and gum arabic.
Described dressing can be the particulate layer, for example Powdered sugar, particulate polyalcohol etc.Described particulate layer can be applied by any method known in the art, and described method comprises: breading adheres to described chewing gum or solid candy district with electrostatic force with described particulate floor; Or mix sand, adhesive (for example water) helps to adhere to described particulate layer.
Described coated composition can be used by any methods known in the art that comprise method described above.Described coated composition can with total chewing gum sugar weight from about 2% to about 60%, more specifically from about 25% to about 45% amount exists.
The solid candy composition
In some embodiments, described multi-region chewing gum composition comprises the confectionery composition district of solid form.Described confectionery composition district can be centered on various structure by an elastomer region at least in part, so that described chewing gum composition is the form of filling with the center that has described confectionery composition district at the center, with the form of the layering that has described confectionery composition district adjacent to elastomer region or between elastomer region, or the like.Described confectionery composition district can be, for example, and the form of particulate, powder, inflation, taffy, the strange sugar of method, Fu Labei, nougat, the foam that stirs, or other solids.Some embodiments of described center filler chewing gum composition also can comprise the 3rd district, and described the 3rd district forms an outer coatings or shell, and described fragility that provides when beginning to chew is provided usually for described outer coatings or shell.This outer coatings or shell can be hard candy shell, soft matrix sugar shell, particulate layer, or the dressing of any other expectation.Described outer coatings or shell can center on described multi-region chewing gum composition at least in part.In some embodiments, described candy can be at the inboard of product or in the outside of product, or described candy can be dispersed in the whole described gum region.
The described candy district of some embodiments is solid composites.Described solid composite can comprise sweet taste material, flavoring, sugar, oil, fat, breast, or other traditional candy manufactured materials.In some embodiments, described solid composite comprises caffeine, and can comprise other active components, and described other active components comprise stimulus, medicament, or replenishers.Active component refers generally to those compositions that is included in the final benefit that offers user's expectation in delivery system and/or the chewing gum composition.In some embodiments, active matter can comprise medicament, nutrients, nutrient drug (nutraceuticals), draft agent, nutritious supplementary pharmaceutical, medicine, medicine etc., and combination, shown in Table A.
The embodiment of useful medicine comprises the ace-inhibitor, the antianginal agent, anti-heart murmur agent, anti-asthmatic agent, anti-hypercholesterolemiccompounds agent (anti-cholesterolemics), analgestic, anesthetic, Anticonvulsants, antidepressant, antidiabetic, the anti diar rhea preparation, antidote, antihistaminic, antihypertensive, antiphlogistic, the agent of lipotropism matter, antimaniacal drugs, the emesis agent, the anti-stroke agent, antithyroid preparation, anticarcinogen, antivirotic, the acne medicine, alkaloid, amino acid preparation, antitussive, anti-hyperuricemia medicine (anti-uricemic drug), antiviral agent, the anabolism preparation, system and nonsystematic anti-infective, antitumor agent, the agent of anti-Parkinson disease, antirheumatic, appetite stimulator, the biological response improver, the blood improver, the bone metabolism regulators, cardiovascalar agent, the central nervous system stimulant, anticholinesterase, contraceptive, separate congested agent, dietary supplements, dopamine-receptor stimulant, mullerianosis controlling agent (management agent), enzyme, the erectile dysfunction therapeutic agent is (as at present with Viagra
TMThe citric acid silaenafil of selling), cause and educate agent, the stomach medicament, the therapeutic agent of taking advantage of a situation, hormone, hypercalcinemia and hypocalcemia controlling agent, immunomodulator, immunodepressant, the antimigraine preparation, the motion sickness therapeutic agent, muscle relaxant, obesity controller, the osteoporosis preparation, oxytocins, the parasympathetic nerve blocking agent, Parasympathomimetic, prostaglandin, the psychotherapy agent, breathe medicament, sedative, smoking cessation assistant (as bromocryptine or nicotine), sympathetic inhibitor, medicament trembles, the urinary tract medicament, vasodilator, laxative, antiacid, ion exchange resin, antipyretic, appetite inhibitor, expectorant, antianxiety agent, antiulcer agent, the anti-inflammatory thing, coronary vasodilator, the brain expander, the external perihaemal canal expander, psychopharmaceutical, stimulant, antihypertensive, vasoconstrictor, the migraine treatment agent, antibiotic, tranquillizer, major tranquilizer, anticarcinogen, anticoagulant, antithrombotic, hypnotic, antemetic, the emesis agent, Anticonvulsants, neuromuscular drug, height and hypoglycemia medicament, thyroid gland and antithyroid preparation, diuretics, convulsion relieving agent, atony of uterus agent (terine relaxant), antiadipositas drug, red blood cell generates medicine, anti-asthmatic agent, the cough suppressant, mucolytic, DNA and gene correction medicine, with and the combination.
The embodiment of the active component that expection is used comprises antiacid, H2-antagonist and analgestic.For instance, the antiacid batching can make up with the calcium carbonate composition or with magnesium hydroxide and/or aluminium hydroxide separately and prepare.In addition, antiacid can be used in combination with the H2-antagonist.
Analgestic comprises opiate and opium derivant, as Oxycontin
TM, brufen, aspirin, Paracetamol and combination thereof, described combination can comprise caffeine alternatively.
Other active constituents of medicine that are used for embodiment comprise that anti-diarrhea agents is (as Immodium
TMAD), antihistaminic, antitussive, separate congested agent, vitamin and flavorants.What expection was herein used also has antianxiety agent (as Xanax
TM); Major tranquilizer is (as Clozaril
TMAnd Haldol
TM), non-steroid antiinflammatory (NSAID ' s, as brufen, naproxen sodium, Voltaren
TMAnd Lodine
TM), antihistaminic is (as Claritin
TM, Hismanal
TM, Relafen
TMAnd Tavist
TM), antemetic is (as Kytril
TMAnd Cesamet
TM), bronchodilator is (as Bentolin
TM, Proventil
TM), antidepressant is (as Prozac
TM, Zoloft
TMAnd Paxil
TM), the anti-migraine agent is (as Imigra
TM), the ACE-inhibitor is (as Vasotec
TM, Capoten
TMAnd Zestril
TM), the anti-Alzheimer disease medicament is (as Nicergoline
TM) and the CaH-antagonist (as Procardia
TM, Adalat
TMAnd Calan
TM).
The welcome H2-antagonist that expection is used comprises Cimetidine, ranitidine hydrochloride, famotidine, nizatidine (nizatidien), Ebrotidine, Mifentidine, Roxatidine, pisatidine and aceroxatidine.
Active matter antiacid composition can include, but is not limited to following: aluminium hydroxide, Dihydroxyaluminum Aminoacetate, aminoacetic acid, aluminum phosphate, dihydroxy aluminium sodium carbonate, bicarbonate, bismuth aluminate, waltherite, basic bismuth carbonate, bismuth subgallate, basic bismuth nitrate, alkali formula salicylic acid (subsilysilate) bismuth, calcium carbonate, calcium phosphate, citrate ions (acid or salt), amion acetic acid, hydrazine aluminum sulfate acid magnesium (hydrate magnesium aluminate sulfate), magaldrate, Almasilate, magnesium carbonate, magnesium glycinate, magnesium hydroxide, magnesia, magnesium trisilicate, milk solid, single-or two alkali calcium phosphate aluminium (aluminum mono-ordibasic calcium phosphate), tricalcium phosphate, saleratus, sodium tartrate, sodium acid carbonate, Almasilate, tartaric acid and salt.
The various nutritious supplementary pharmaceuticals that comprise any vitamin or mineral matter in fact also can be used as active component.For instance, can use vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, Cobastab
6, Cobastab
12, thiamine, riboflavin, biotin, folic acid, nicotinic acid, pantothenic acid, sodium, potassium, calcium, magnesium, phosphorus, sulphur, chlorine, iron, copper, iodine, zinc, selenium, manganese, choline, chromium, molybdenum, fluorine, cobalt with and combination.
Can as the embodiment of the nutritious supplementary pharmaceutical of active component U.S. Patent Application Publication No. 2003/0157213A1,2003/0206993 and 2003/0099741A1 in illustrate, described patent is incorporated into this paper by integral body by reference for all purposes.
Various draft agent also can be used as active component, has the draft agent of various different pharmacy or meal supplement character as those.The draft agent generally is pharmaceutically to use or to be used for the fragrant plant of seasoning or plant part and/or its extract.Suitable draft agent can be used individually or with various different mixtures.The active component that is derived from herbaceous plant or autonomic drug source is known as phytochemical sometimes.The classification of phytochemical includes, but is not limited to Polyphenols, flavonoid class, flavanol compound, flavonols, flavanone, isoflavan ketone, anthocyan, pyrocatechol and flavanone (flavonones).Herbal medicine commonly used comprises Echinacea, groundraspberry, marigold, rosemary,, thyme, click (Kava Kava), aloe, bloodroot, grapefruit seed extract, black wool Liang (Black Cohosh), genseng, guarana (guarana), mossberry, ginkgo, St. john's wort, evening primrose oil, the yogimbine bark, green tea, EGCG (Epigallo-catechin gallate (EGCG) (epigallocatechin gallate)), Chinese ephedra, the agate card, cocoa polyphenol, cowberry, lutern with and the combination.
Some embodiments comprise caffeine in described candy district.Described caffeine can exist with any pharmaceutically effective dose, and has shown with the dosage from the about 30mg-150mg of each part it is effective.Present one effective OTC dosage is the about 100mg of each part.The size of traditional portion (serving) is about 1-5 piece chewing gum.
Table A-active matter
Component |
Amount |
I. realizable material |
|
A. coolant agent |
|
Menthol |
??10-500ppm |
Xylitol |
??5-95% |
Antierythrite |
??5-95% |
Terpane |
??10-500ppm |
Component |
Amount |
Menthones |
??10-500ppm |
Menthyl acetate |
??10-500ppm |
Menthyl salicylate |
??10-500ppm |
??WS-23 |
??10-500ppm |
??WS-3 |
??10-500ppm |
The butanedioic acid menthyl ester |
??10-500ppm |
Component |
Amount |
3,1-peppermint oxygen base the third-1,2-glycol |
??10-500ppm |
Glutarate |
??10-500ppm |
|
|
B. warm flavor agent |
|
The vanillic alcohol n-butyl ether |
??1-1500ppm |
The vanillic alcohol positive propyl ether |
??1-1500ppm |
The vanillic alcohol isopropyl ether |
??1-1500ppm |
The vanillic alcohol isobutyl ether |
??1-1500ppm |
Vanillic alcohol n-amino ethers |
??1-1500ppm |
The vanillic alcohol isoamyl ether |
??1-1500ppm |
The vanillic alcohol n-hexyl ether |
??1-1500ppm |
The vanillic alcohol methyl ether |
??1-1500ppm |
The vanillic alcohol ether |
??1-1500ppm |
Component |
Amount |
Zingiberol |
??1-1500ppm |
Salad oil |
??1-1500ppm |
Zingiberone phenol |
??1-1500ppm |
Zingerone |
??1-1500ppm |
Capsaicine |
??1-1500ppm |
Dihydrocapsaicin |
??1-1500ppm |
Nordihydrocapsaicin |
??1-1500ppm |
Homocapsaicin |
??1-1500ppm |
Homodihydrocapsaicin |
??1-1500ppm |
Ethanol |
??1-1500ppm |
Isopropyl alcohol |
??1-1500ppm |
Isoamyl alcohol |
??1-1500ppm |
Phenmethylol |
??1-1500ppm |
Component |
Amount |
Glycerine |
??1-1500ppm |
Chloroform |
??1-1500ppm |
Eugenol |
??1-1500ppm |
Cinnamon oil |
??1-1500ppm |
Cinnamic acid |
??1-1500ppm |
|
|
C. fiber crops thorn agent |
|
Herba Cancriniae lasiocarpae oleoresin or Herba Cancriniae lasiocarpae (para cress) |
??5-500ppm |
Japan's Chinese pepper extract |
??5-500ppm |
Fructus piperis nigrum extract |
??5-500ppm |
Echinacea (Echinacea) extract |
??5-500ppm |
Component |
Amount |
Suterberry (Northern Prickly Ash) extract |
??5-500ppm |
Component |
Amount |
The hot red pepper oleoresin |
??5-500ppm |
Effervescent agent |
??5-500ppm |
|
|
II. local flavor thing |
|
Spearmint oil |
??0.01-10.0% |
Cinnamon oil |
??0.01-10.0% |
Wintergreen |
??0.01-10.0% |
Mentha piperita oil |
??0.01-10.0% |
Caryophyllus oil |
??0.01-10.0% |
Oreodaphene |
??0.01-10.0% |
Aniseed oil |
??0.01-10.0% |
Eucalyptus oil |
??0.01-10.0% |
Thyme linaloe oil |
??0.01-10.0% |
Component |
Amount |
Cedar leaves oil |
??0.01-10.0% |
Mace oil |
??0.01-10.0% |
Allspice |
??0.01-10.0% |
Sage oil |
??0.01-10.0% |
Mace |
??0.01-10.0% |
Almond oil |
??0.01-10.0% |
Cassia oil (Cassia oil) |
??0.01-10.0% |
Vanilla |
??0.01-10.0% |
Lemon |
??0.01-10.0% |
Orange |
??0.01-10.0% |
Bitter orange |
??0.01-10.0% |
Grape fruit |
??0.01-10.0% |
Apple |
??0.01-10.0% |
Component |
Amount |
Pears |
??0.01-10.0% |
Peach |
??0.01-10.0% |
Grape |
??0.01-10.0% |
Strawberry |
??0.01-10.0% |
Raspberry |
??0.01-10.0% |
Cherry |
??0.01-10.0% |
Plum |
??0.01-10.0% |
Pineapple |
??0.01-10.0% |
Apricot |
??0.01-10.0% |
Chocolate |
??0.01-10.0% |
Laughable |
??0.01-10.0% |
Maple |
??0.01-10.0% |
Milk syrup (dulce de leche) |
??0.01-10.0% |
Component |
Amount |
Raisins (raisin) |
??0.01-10.0% |
Caramel |
??0.01-10.0% |
Cinnamyl acetate |
??0.01-10.0% |
Component |
Amount |
Cinnamic acid |
??0.01-10.0% |
Citral diethyl acetal |
??0.01-10.0% |
The acetic acid dihydro carvyl |
??0.01-10.0% |
Formic acid cloves phenolic ester |
??0.01-10.0% |
Right-the methyl anisole |
??0.01-10.0% |
Acetaldehyde |
??0.01-10.0% |
Benzaldehyde |
??0.01-10.0% |
Anisic aldehyde |
??0.01-10.0% |
Cinnamic acid |
??0.01-10.0% |
Component |
Amount |
Citral |
??0.01-10.0% |
Neral |
??0.01-10.0% |
Capraldehyde |
??0.01-10.0% |
Ethyl vanillin |
??0.01-10.0% |
Perfume flower (heliotrope) |
??0.01-10.0% |
Vanillic aldehyde |
??0.01-10.0% |
Jasminal |
??0.01-10.0% |
Butyraldehyde |
??0.01-10.0% |
Valeral |
??0.01-10.0% |
Citronellal |
??0.01-10.0% |
Capraldehyde |
??0.01-10.0% |
Aldehyde C-8 |
??0.01-10.0% |
Aldehyde C-9 |
??0.01-10.0% |
Component |
Amount |
Aldehyde C-12 |
??0.01-10.0% |
2-ethyl butyraldehyde |
??0.01-10.0% |
Hexenoic aldehyde |
??0.01-10.0% |
Tolyl aldehyde |
??0.01-10.0% |
Veratraldehyde |
??0.01-10.0% |
2,6-dimethyl-5-heptenal |
??0.01-10.0% |
2,6-dimethyl octanal |
??0.01-10.0% |
2-laurylene aldehyde |
??0.01-10.0% |
The strawberry fruit juice jelly |
??0.01-10.0% |
Pomegranate |
??0.01-10.0% |
Beef |
??0.01-10.0% |
Chicken |
??0.01-10.0% |
Cheese |
??0.01-10.0% |
Component |
Amount |
Onion |
??0.01-10.0% |
|
|
III. the sense of taste |
|
A. sweet taste material |
|
Sucrose |
??5-100% |
Dextrose (dextrose) |
??5-100% |
Maltose |
??5-100% |
Dextrin |
??5-100% |
Component |
Amount |
Wood sugar |
??5-100% |
Ribose |
??5-100% |
Glucose |
??5-100% |
Mannose |
??5-100% |
Component |
Amount |
Galactolipin |
??5-100% |
Fructose |
??5-100% |
Invert sugar |
??5-100% |
FOS syrup (fructo oligo saccharide syrups) |
??5-100% |
The starch of partial hydrolysis |
??5-100% |
Corn-syrup solids |
??5-100% |
D-sorbite |
??5-100% |
Xylitol |
??5-100% |
Mannitol |
??5-100% |
Galactitol |
??5-100% |
Maltitol |
??5-100% |
Isomalt |
??5-100% |
Lactitol |
??5-100% |
Component |
Amount |
Antierythrite |
??5-100% |
Hydrogenated starch hydrolysate |
??5-100% |
Stevia rebaudianum (stevia) |
??10-20,000ppm |
Dihydrochalcone |
??10-20,000ppm |
Not interior albumen |
??10-20,000ppm |
Stevioside |
??10-20,000ppm |
Glycyrrhizin |
??10-20,000ppm |
Dihydroriboflavin (dihydroflavenol) |
??10-20,000ppm |
The amino chain acid ester acid amides of L-diamino dicarboxylic acid |
??10-20,000ppm |
Asccharin sodium salt or asccharin calcium salt |
??10-20,000ppm |
Cyclohexyl-n-sulfonate |
??10-20,000ppm |
3,4-dihydro-6-methyl isophthalic acid, 2,3-Evil thiazine-4-ketone-2, the sodium salt of 2-dioxide, ammonium salt or calcium salt |
??10-20,000ppm |
Component |
Amount |
Acesulfame potassium |
??10-20,000ppm |
The free acid form of asccharin |
??10-20,000ppm |
Aspartame |
??10-20,000ppm |
Alitame |
??10-20,000ppm |
Knob is sweet |
??10-20,000ppm |
L-aspartoyl-L-phenyl glycerine and L-aspartoyl-L-2, the methyl esters of 5-dihydro phenyl-glycine |
??10-20,000ppm |
L-aspartoyl-2,5-dihydro-L-phenylalanine |
??10-20,000ppm |
L-aspartoyl-L-(l-cyclohexenyl group)-alanine |
??10-20,000ppm |
Sucralose (sucralose) |
??10-20,000ppm |
1-chloro-1 '-deoxidation sucrose |
??10-20,000ppm |
4-chloro-4-deoxidation-α-D-galactopyranose base-α-D-fructofuranoside |
??10-20,000ppm |
4-chloro-4-deoxidation sucralose |
??10-20,000ppm |
Component |
Amount |
Component |
Amount |
4-chloro-4-deoxidation-α-D-galactopyranose base-1-chloro-1-deoxidation-β-D-fructose-furanoside |
??10-20,000ppm |
4,1 '-two chloro-4,1 '-the dideoxy sucralose |
??10-20,000ppm |
1 ', 6 '-dichloro 1 ', 6 '-dideoxy sucrose |
??10-20,000ppm |
4-chloro-4-deoxidation-α-D-galactopyranose base-1,6-two chloro-1,6-dideoxy-beta-D-fructofuranose glycosides |
??10-20,000ppm |
4,1 ', 6 '-three chloro-4,1 ', 6 '-three deoxidation sucralose |
??10-20,000ppm |
4,6-two chloro-4,6-dideoxy-α-D-galactopyranose base-6-chloro-6-deoxidation-beta-D-fructofuranose glycosides |
??10-20,000ppm |
4,6,6 '-three chloro-, 4,6,6 '-three deoxidation sucralose |
??10-20,000ppm |
6,1 ' 6 '-three chloro-6,1 ', 6 '-three deoxidation sucrose |
??10-20,000ppm |
4,6-two chloro-4,6-dideoxy-α-D-gala-pyrans glycosyl-1,6-two chloro-1,6-dideoxy-beta-D-fructofuranose glycosides |
??10-20,000ppm |
Component |
Amount |
4,6,1 ', 6 '-tetrachloro 4,6,1 ', 6 '-four deoxy-galactoses-sucrose |
??10-20,000ppm |
4,6,1 ', 6 '-four deoxidation sucrose |
??10-20,000ppm |
Sweet I of rope horse and II |
??10-20,000ppm |
That booth not |
??10-20,000ppm |
|
|
B. tart flavour |
|
Acetic acid |
??0.00005-10% |
Adipic acid |
??0.00005-10% |
Ascorbic acid |
??0.00005-10% |
Butyric acid |
??0.00005-10% |
Citric acid |
??0.00005-10% |
Formic acid |
??0.00005-10% |
Fumaric acid |
??0.00005-10% |
Component |
Amount |
Gluconic acid |
??0.00005-10% |
Lactic acid |
??0.00005-10% |
Phosphoric acid |
??0.00005-10% |
Malic acid |
??0.00005-10% |
Oxalic acid |
??0.00005-10% |
Butanedioic acid |
??0.00005-10% |
Tartaric acid |
??0.00005-10% |
|
|
C. bitter taste/astringent taste |
|
Quinine |
??0.01-100ppm |
Naringin |
??0.01-100ppm |
Quassia |
??0.01-100ppm |
Phenylthiourea (Phenyl thiocarbamide (PTC)) |
??0.01-100ppm |
Component |
Amount |
-n-propylthiouracil (6-n-propylthiouracil (Prop)) |
??0.01-100ppm |
Alum |
??0.01-100ppm |
Salicin |
??0.01-100ppm |
Caffeine |
??0.01-100ppm |
Component |
Amount |
|
|
D. saline taste |
|
Sodium chloride |
??0.01-1% |
Calcium chloride |
??0.01-1% |
Potassium chloride |
??0.01-1% |
L-lysine |
??0.01-1% |
|
|
IV. function reagent |
|
A. surfactant |
|
Component |
Amount |
Be selected from by C
8-C
24The soap of the group of forming
|
??0.001-2% |
Palmitoleic acid |
??0.001-2% |
Oleic acid |
??0.001-2% |
Eleostearic acid |
??0.001-2% |
Butyric acid |
??0.001-2% |
Caproic acid |
??0.001-2% |
Sad |
??0.001-2% |
Capric acid |
??0.001-2% |
Laurate |
??0.001-2% |
Myristic acid |
??0.001-2% |
Palmitic acid |
??0.001-2% |
Stearic acid |
??0.001-2% |
Castor oil acid |
??0.001-2% |
Component |
Amount |
Arachidic acid |
??0.001-2% |
Mountain Yu acid |
??0.001-2% |
Lignoceric acid |
??0.001-2% |
Cerinic acid |
??0.001-2% |
Sulfated butyl oleate |
??0.001-2% |
Medium chain and long-chain fatty acid ester |
??0.001-2% |
Enuatrol |
??0.001-2% |
The salt of fumaric acid |
??0.001-2% |
Glomate potassium |
??0.001-2% |
The organic acid esters of mono-and diglycerides |
??0.001-2% |
Stearoyl list glycerine citrate |
??0.001-2% |
Amber stearin (succistearin) |
??0.001-2% |
Dioctyl sulfuration sodium succinate |
??0.001-2% |
Component |
Amount |
Glycerol tristearate |
??0.001-2% |
Lecithin |
??0.001-2% |
The hydroxylating lecithin |
??0.001-2% |
NaLS |
??0.001-2% |
Acetylated monoglyceride |
??0.001-2% |
Succinylated monoglycerides |
??0.001-2% |
The citrate monoglyceride |
??0.001-2% |
The ethoxylation mono-and diglycerides |
??0.001-2% |
Component |
Amount |
Arlacel-60 |
??0.001-2% |
Stearoyl-2-calcium lactate |
??0.001-2% |
Stearoyl lactate |
??0.001-2% |
Glycerine and 1, the lactic acid fatty acid ester of 2-propane diols |
??0.001-2% |
Component |
Amount |
??C
8-C
24The glycerine of aliphatic acid-newborn ester (lactoesters)
|
??0.001-2% |
??C
8-C
24The polyglycerol ester of aliphatic acid
|
??0.001-2% |
Propylene glycol alginate |
??0.001-2% |
Sucrose C
8-C
24Fatty acid ester
|
??0.001-2% |
The diacetyl tartaric acid of mono-and diglycerides and citrate |
??0.001-2% |
Glyceryl triacetate |
??0.001-2% |
Sarcosinate (sarcosinate) surfactant |
??0.001-2% |
Isethionate (isethionate) surfactant |
??0.001-2% |
Taurate (tautate) surfactant |
??0.001-2% |
Pluronics (pluronics) |
??0.001-2% |
The polyoxyethylene alkene condensate of alkyl phenol |
??0.001-2% |
The product that the condensation reaction of the product of ethylene oxide and propylene oxide and ethylenediamine is derived |
??0.001-2% |
Component |
Amount |
The ethylene oxide condensation product of fatty alcohol |
??0.001-2% |
The long-chain tertiary amine oxide |
??0.001-2% |
Long-chain oxidation tertiary phosphine |
??0.001-2% |
The long-chain dialkyl sulphoxide |
??0.001-2% |
|
|
B. flavorants |
|
Spearmint oil |
??0.001-10% |
Mentha piperita oil |
??0.001-10% |
Wintergreen |
??0.001-10% |
Sassafras oil |
??0.001-10% |
Chlorophyll oil |
??0.001-10% |
Citral oil |
??0.001-10% |
Geraniol oil |
??0.001-10% |
Component |
Amount |
Cardamom oil |
??0.001-10% |
Caryophyllus oil |
??0.001-10% |
Sage oil |
??0.001-10% |
The Sheep's-parsley carbolic oil |
??0.001-10% |
Eucalyptus oil |
??0.001-10% |
Cardamom oil |
??0.001-10% |
The bark of official magnolia (magnolia bark) is extracted oil |
??0.001-10% |
Marjoram oil |
??0.001-10% |
Cinnamon oil |
??0.001-10% |
Lemon oil |
??0.001-10% |
Limette oil |
??0.001-10% |
Oil of grapefruit |
??0.001-10% |
Orange oil |
??0.001-10% |
Component |
Amount |
Component |
Amount |
Cinnamic acid |
??0.001-10% |
Salicylide |
??0.001-10% |
Menthol |
??0.001-10% |
Carvol |
??0.001-10% |
??iso-garrigol |
??0.001-10% |
Anethole (anethole) |
??0.001-10% |
Zinc citrate |
??0.01-25% |
Zinc acetate |
??0.01-25% |
Zinc fluoride |
??0.01-25% |
The zinc sulfate ammonium |
??0.01-25% |
Zinc bromide |
??0.01-25% |
Zinc iodide |
??0.01-25% |
Component |
Amount |
Zinc chloride |
??0.01-25% |
Zinc nitrate |
??0.01-25% |
Zinc fluosilicate |
??0.01-25% |
ZnG |
??0.01-25% |
Zinc tartrate |
??0.01-25% |
Zinc succinate |
??0.01-25% |
Zinc formate |
??0.01-25% |
Zinc chromate |
??0.01-25% |
Zinc phenolsulfonate |
??0.01-25% |
Dithionic acid zinc |
??0.01-25% |
Zinc sulfate |
??0.01-25% |
Silver nitrate |
??0.01-25% |
Zinc salicylate |
??0.01-25% |
Component |
Amount |
Zinc glycerophosphate |
??0.01-25% |
Copper nitrate |
??0.01-25% |
Chlorophyll |
??0.01-25% |
Copper chlorophyll |
??0.01-25% |
Chlorophyllin |
??0.01-25% |
Cotmar |
??0.5-70% |
Chlorine dioxide |
??0.025-0.50% |
Beta-schardinger dextrin- |
??0.1-5% |
Zeolite |
??0.1-5% |
The silica-based material |
??0.1-5% |
Carbon-based material |
??0.1-5% |
Enzyme, for example laccase, papain, krill enzyme (krillase), amylase, glucose oxidase |
??0.1-5% |
|
|
Component |
Amount |
C. antimicrobial |
|
Cetylpyridinium Chloride (cetylpyridinium chloride) |
??0.01-1% |
Zinc compound |
??0.01-25% |
Copper compound |
??0.01-25% |
Component |
Amount |
|
|
D. antiseptic |
|
Chlorhexidine |
??0.0025-2% |
Alexidine |
??0.0025-2% |
Quaternary ammonium salt |
??0.0025-2% |
Benzethonium chloride (benzethonium chloride) |
??0.0025-2% |
Cetylpyridinium Chloride |
??0.0025-2% |
2,4,4 '-three chloro-2 '-hydroxyl-diphenyl ether (triclosan) |
??0.0025-2% |
|
|
Component |
Amount |
E. anticalculus agent |
|
Pyrophosphate |
??1-6% |
Triphosphate |
??0.1-10% |
Quadrafos |
??0.1-10% |
Polyphosphonate |
??0.1-10% |
Pyrophosphoric acid two alkali metal salts |
??1-6% |
Polyphosphoric acid four alkali metal salts |
??0.1-10% |
Tetrasodium pyrophosphate |
??1-6% |
Tetrapotassium pyrophosphate |
??1-6% |
Sodium phosphate trimer |
??0.1-10% |
|
|
F. antiplaque (plaque) agent |
|
Chlorhexidine |
??0.0025-2% |
Component |
Amount |
Triclosan |
??0.01-2% |
Hexetidine |
??0.01-2% |
Zinc citrate |
??0.01-25% |
Fluorones? |
??__%-__% |
Essential oil |
??0.001-10% |
NaLS |
??0.001-2% |
|
|
G. fluoride compound |
|
Sodium fluoride |
??0.01-1% |
Sodium monofluorophosphate |
??0.01-1% |
Stannous fluoride |
??0.01-1% |
|
|
H. quaternary ammonium compound |
|
Benzalkonium chloride (benzalkonium chloride) |
??0.01-1% |
Component |
Amount |
Benzethonium chloride |
??0.01-1% |
Cetalkonium chloride (cetalkonium chloride) |
??0.01-1% |
Cetrimonium bromide (cetrimide) |
??0.01-1% |
Bromine palm fibre trimethyl ammonium (cetrimonium bromide) |
??0.01-1% |
Cetylpyridinium Chloride |
??0.01-1% |
Chlorination glycidol trimethyl ammonium |
??0.01-1% |
Stearyl dimethyl benzyl ammonium chloride (stearalkonium chloride) |
??0.01-1% |
Component |
Amount |
|
|
I. remineralizing agent |
|
Phosphoeptide-amorphous calcium phosphate |
??0.1-5% |
Casein phosphoric acid albumen-calcium phosphate complex |
??0.1-5% |
The calcium phosphate of CPP stabilisation |
??0.1-5% |
|
|
Component |
Amount |
J. pharmaceutical actives |
|
Medicine or medicament |
??0.0001-10% |
Vitamin and other dietary supplements |
??0.0001-10% |
Mineral matter |
??0.0001-10% |
Caffeine |
??0.0001-10% |
Nicotine |
??0.0001-10% |
Fruit juice |
??2-60% |
|
|
K. micronutrient |
|
Vitamin A |
??0.0001-10% |
Vitamin D |
??0.0001-10% |
Vitamin E |
??0.0001-10% |
Vitamin K |
??0.0001-10% |
Component |
Amount |
Vitamin C (ascorbic acid) |
??0.0001-10% |
Vitamin(e) B group (thiamine or B1, riboflavin or B2, nicotinic acid or B3, pyridoxol or B6, folic acid or B9, cyanocobalamin or B12, pantothenic acid, biotin |
??0.0001-10% |
Sodium |
??0.0001-10% |
Magnesium |
??0.0001-10% |
Chromium |
??0.0001-10% |
Iodine |
??0.0001-10% |
Iron |
??0.0001-10% |
Manganese |
??0.0001-10% |
Calcium |
??0.0001-10% |
Copper |
??0.0001-10% |
Fluoride |
??0.0001-10% |
Potassium |
??0.0001-10% |
Component |
Amount |
Phosphorus |
??0.0001-10% |
Molybdenum |
??0.0001-10% |
Selenium |
??0.0001-10% |
Zinc |
??0.0001-10% |
The L-carnitine |
??0.0001-10% |
Choline |
??0.0001-10% |
Co-Q10 |
??0.0001-10% |
Alpha-lipoic acid |
??0.0001-10% |
Omega-3-fatty acid |
??0.0001-10% |
Pepsin |
??0.0001-10% |
Component |
Amount |
Phytase (phytase) |
??0.0001-10% |
Trypsase |
??0.0001-10% |
Component |
Amount |
Lipase |
??0.0001-10% |
Protease (proteases) |
??0.0001-10% |
Cellulase |
??0.0001-10% |
Ascorbic acid |
??0.0001-10% |
Citric acid |
??0.0001-10% |
Rosemary oil |
??0.0001-10% |
Vitamin A |
??0.0001-10% |
Vitamin E phosphate |
??0.0001-10% |
Tocopherol |
??0.0001-10% |
Two-alpha-tocopherol phosphate |
??0.0001-10% |
Tocotrienols |
??0.0001-10% |
Alpha lipoic acid |
??0.0001-10% |
Dihydrolipoic acid |
??0.0001-10% |
Component |
Amount |
Lutein |
??0.0001-10% |
Beta-cryptoxanthin |
??0.0001-10% |
Lycopene |
??0.0001-10% |
Lutern |
??0.0001-10% |
Zeaxanthin |
??0.0001-10% |
Beta carotene |
??0.0001-10% |
Carrotene |
??0.0001-10% |
The carotenoid (carotenoids) that mixes |
??0.0001-10% |
Polyphenol |
??0.0001-10% |
Flavonoids |
??0.0001-10% |
Carotenoid (cartotenoids) |
??0.0001-10% |
Chlorophyll |
??0.0001-10% |
Chlorophyllin |
??0.0001-10% |
Component |
Amount |
Fiber |
??0.0001-10% |
Anthocyanidin (anthocyanins) |
??0.0001-10% |
Cyanidin (cyaniding) |
??0.0001-10% |
Delphinidin |
??0.0001-10% |
Malvidin |
??0.0001-10% |
Pelargonidin |
??0.0001-10% |
Peonidin (peonidin) |
??0.0001-10% |
Morning glory pigment (petunidin) |
??0.0001-10% |
Flavanols |
??0.0001-10% |
Flavonols |
??0.0001-10% |
Catechol |
??0.0001-10% |
Epicatechol |
??0.0001-10% |
Epigallocatechin (Epigallocatechin) |
??0.0001-10% |
Component |
Amount |
Epigallo-catechin gallate (EGCG) (epigallocatechingallate) |
??0.0001-10% |
Component |
Amount |
Theaflavin |
??0.0001-10% |
Congo red element (thearubigin) |
??0.0001-10% |
OPC (proanthocyanin) |
??0.0001-10% |
Quercetin (quercetin) |
??0.0001-10% |
Kaempferol (kaempferol) |
??0.0001-10% |
Myricetin |
??0.0001-10% |
Isorhamnetin (isorhamnetin) |
??0.0001-10% |
Flavanone hesperetin (flavononeshesperetin) |
??0.0001-10% |
Naringenin (naringenin) |
??0.0001-10% |
Eriodictyol |
??0.0001-10% |
Component |
Amount |
Hesperetin (tangeretin) |
??0.0001-10% |
Flavones |
??0.0001-10% |
Apiolin (apigenin) |
??0.0001-10% |
Cyanidenon (luteolin) |
??0.0001-10% |
Lignanoid |
??0.0001-10% |
Phytoestrogen (phytoestrogen) |
??0.0001-10% |
Resveratrol |
??0.0001-10% |
Isoflavones (isoflavone) |
??0.0001-10% |
Daidzein (daidzein) |
??0.0001-10% |
Genistein (genistein) |
??0.0001-10% |
Isoflavones |
??0.0001-10% |
|
|
L. throat care agent |
|
Component |
Amount |
(1) analgesia, anesthesia, analgesic and antiphlogistic |
|
Menthol |
??10-500ppm |
Phenol |
??0.1-50% |
Hexylresorcinol |
??0.1-50% |
Benzocainum |
??0.1-50% |
Dyclonine hydrochloride |
??0.1-50% |
Phenmethylol |
??0.1-50% |
Saligenin (salicyl alcohol) |
??0.1-50% |
Paracetamol |
??0.1-50% |
Aspirin |
??0.1-50% |
Diclofenac |
??0.1-50% |
Diflonid |
??0.1-50% |
Etodolac |
??0.1-50% |
Component |
Amount |
Fenoprofen |
??0.1-50% |
Flurbiprofen |
??0.1-50% |
Brufen |
??0.1-50% |
Ketoprofen |
??0.1-50% |
Ketorolac (ketorolac) |
??0.1-50% |
Nabumetone (nabumetone) |
??0.1-50% |
Naproxen |
??0.1-50% |
Component |
Amount |
Piroxicam |
??0.1-50% |
Caffeine |
??0.0001-10% |
Lidocaine |
??0.1-50% |
Benzocainum |
??0.1-50% |
Phenol |
??0.1-50% |
Component |
Amount |
Dyclonine |
??0.1-50% |
Benzonatate (benzonotate) |
??0.1-50% |
(2) moderator (demulcent) |
|
Elm bark (slippery elm bark) |
??0.1-10% |
Pectin |
??0.1-10% |
Gelatin |
??0.1-10% |
(3) disinfectant (antiseptic) |
|
Cetylpyridinium Chloride |
??0.01-1% |
Domiphen bromide (domiphen bromide) |
??0.01-1% |
Dequalinium Chloride (dequalinium chloride) |
??0.01-1% |
(4) pectoral |
|
Chlophedianol hydrochloride (chlophedianol hydrochloride) |
??0.0001-2% |
Codeine |
??0.0001-2% |
Component |
Amount |
Codeine phosphate |
??0.0001-2% |
Codeine sulfate |
??0.0001-2% |
Dextromethorphan |
??0.0001-2% |
Dextromethorphan hydrobromide |
??0.0001-2% |
Diphenhydramine citrate |
??0.0001-2% |
Bagodryl hydrochloride |
??0.0001-2% |
Dextrorphan (dextrorphan) |
??0.0001-2% |
Diphenhydramine |
??0.0001-2% |
Hydrocodone |
??0.0001-2% |
Narcotine |
??0.0001-2% |
Oxycodone |
??0.0001-2% |
Pentoxyverine |
??0.0001-2% |
(5) the throat agent of releiving |
|
Component |
Amount |
Honey |
??0.5-90% |
Propolis (propolis) |
??0.1-10% |
Aloe (aloe vera) |
??0.1-10% |
Glycerine |
??0.1-10% |
Menthol |
??10-500ppm |
(6) cough suppressant |
|
Codeine |
??0.0001-2% |
Antihistaminic |
??0.0001-2% |
Dextromethorphan |
??0.0001-2% |
Isoprel |
??0.0001-2% |
(7) expectorant |
|
Ammonium chloride |
??0.0001-2% |
Component |
Amount |
Component |
Amount |
Croak Fen Naxin (guaifenesin) |
??0.0001-2% |
Fluid ipecac extract (ipecac fluid extract) |
??0.0001-2% |
KI |
??0.0001-2% |
(8) mucolytic agent (mucolytics) |
|
Acetylcysteine (acetylcycsteine) |
??0.0001-2% |
Ambroxol |
??0.0001-2% |
Bromhexine |
??0.0001-2% |
(9) antihistaminic (antihistamines) |
|
Acrivastine (Acrivastine) |
??0.05-10% |
Azatadine |
??0.05-10% |
Brompheniramine |
??0.05-10% |
Chlorphenamine (chlorpheniramine) |
??0.05-10% |
Clemastine (clemastine) |
??0.05-10% |
Component |
Amount |
Cyproheptadine (cyproheptadine) |
??0.05-10% |
Dexbrompheniramine |
??0.05-10% |
Dramamine |
??0.05-10% |
Diphenhydramine |
??0.05-10% |
Doxylamine |
??0.05-10% |
Hydroxyzine |
??0.05-10% |
Meclizine (meclizine) |
??0.05-10% |
Phenindamine |
??0.05-10% |
Phenyltoloxamine |
??0.05-10% |
Phenergan |
??0.05-10% |
Pyrilamine |
??0.05-10% |
Tripelennamine |
??0.05-10% |
Triprolidine (triprolidine) |
??0.05-10% |
Component |
Amount |
Astemizole |
??0.05-10% |
Cetirizine (cetirizine) |
??0.05-10% |
Ebastine (ebastine) |
??0.05-10% |
Fexofenadine (fexofenadine) |
??0.05-10% |
Loratadine (loratidine) |
??0.05-10% |
RMI 9918 |
??0.05-10% |
(10) nose decongestant |
|
Phenylpropanolamine |
??0.1-50% |
Pseudoephedrine |
??0.1-50% |
Ephedrine |
??0.1-50% |
Phyenlephrinium (phenylephrine) |
??0.1-50% |
Oxymetazoline |
??0.1-50% |
Menthol |
??0.1-50% |
Component |
Amount |
Camphor |
??0.1-50% |
Borneol |
??0.1-50% |
Ephedrine |
??0.1-50% |
Eucalyptus oil |
??0.001-10% |
Component |
Amount |
Mentha piperita oil |
??0.001-10% |
Gaultherolin |
??0.001-10% |
Bornyl acetate |
??0.001-10% |
Lavender oil |
??0.001-10% |
The horseradish extract |
??0.001-10% |
The horseradish extract |
??0.001-10% |
|
|
M. dental whitening/stain remover |
|
Component |
Amount |
Surfactant |
??0.001-2% |
Chelating agent |
??0.1-10% |
Rubbing agent |
??0.1-5% |
Oxidant |
??0.1-5% |
Hydrolytic reagent |
??0.1-5% |
|
|
N. physical promoting agent |
|
Caffeine |
??0.0001-10% |
Vitamin |
??0.0001-10% |
Mineral matter |
??0.0001-10% |
Amino acid |
??0.0001-10% |
Ginseng extract |
??0.0001-10% |
Ginkgo biloba extract |
??0.0001-10% |
Component |
Amount |
That takes (guarana) extract melon |
??0.0001-10% |
Green-tea extract |
??0.0001-10% |
Taurine |
??0.0001-10% |
Kola nut extract (kola nut extract) |
??0.0001-10% |
Ilex paraguarensis leaf (yerba mate leaf) |
??0.0001-10% |
Nicotinic acid |
??0.0001-10% |
Root of Rhodiola sachalinensis extract (rhodiola root extract) |
??0.0001-10% |
|
|
O. be absorbed in the power promoting agent |
|
Caffeine |
??0.0001-10% |
Ginkgo biloba extract |
??0.0001-10% |
Centella (gotu cola (centella asiatica)) |
??0.0001-10% |
German Chamomile (German chamomile) |
??0.0001-10% |
Component |
Amount |
Oat (avina sativa) |
??0.0001-10% |
Phosphatidylserine (phosphatidyl serine) |
??0.0001-10% |
Doctor's tea (aspalathus linearis) |
??0.0001-10% |
Pregnenolone |
??0.0001-10% |
Root of Rhodiola sachalinensis extract (rhodiola root extract) |
??0.0001-10% |
Theanine |
??0.0001-10% |
Vinpocetine |
??0.0001-10% |
|
|
P. appetite inhibitor |
|
Component |
Amount |
Caffeine |
??0.0001-10% |
That takes extract melon |
??0.0001-10% |
The inferior cactus (hoodia gordonii) of butterfly |
??0.0001-10% |
Component |
Amount |
Glucomannans |
??0.0001-10% |
Calcium |
??0.0001-10% |
HCA extract (garcinia cambogia extract) |
??0.0001-10% |
Positive acetyl tyrosine |
??0.0001-10% |
Soybean lecithin |
??0.0001-10% |
|
|
V. pigment |
|
Annatto extract (annatto extract) |
??0.5-20% |
Beta carotene |
??0.5-20% |
Canthaxanthin |
??0.5-20% |
Grape extract (grape color extract) |
??0.5-20% |
Turmeric oleoresin (turmeric oleoresin) |
??0.5-20% |
β-A Piao-8 '-carotenal (B-Apo-8 '-carotenal) |
??0.5-20% |
Component |
Amount |
Sugar beet powder |
??0.5-20% |
Caramel colorant |
??0.5-20% |
Carmine pigment (carmine) |
??0.5-20% |
Cochineal extract (cochineal extract) |
??0.5-20% |
Grape skin extract (grape skin extract) |
??0.5-20% |
Safflower (saffron) |
??0.5-20% |
Yellow ginger (tumeric) |
??0.5-20% |
Titanium dioxide |
??0.05-2% |
F.D.﹠C. blue No. 1 |
??0.05-2% |
F.D.﹠C. blue No. 2 |
??0.05-2% |
F.D.﹠C. green No. 1 |
??0.05-2% |
F.D.﹠C. red No. 40 |
??0.05-2% |
F.D.﹠C. red No. 3 |
??0.05-2% |
Component |
Amount |
F.D.﹠C. yellow No. 6 |
??0.05-2% |
F.D.﹠C. yellow No. 5 |
??0.05-2% |
Described solid candy composition is not limited to hard, saturated solid, and can comprise the solid that is exposed to inflation, foam that for example stirs (whips) and Fu Labei.Described solid composite also can comprise very sugar of method, nougat, taffy, or other moldable solids.Described solid composite may further include infusion sugar or based on the candy of isomalt.Further, described solid composite can still be free regardless of what compress with particulate or powder type.Described solid composite can be the combination of solid extraly, solid suspension for example, and wherein particulate is dispersed in anti-that chew or the infusion sugar solid.
Described solid candy can comprise entrapped sweet taste material or particulate, and these particulates can comprise extra local flavor thing or material, and this will be understood by those skilled in the art.For example, in the U.S. Patent number 4,911,934 of authorizing people such as Yang entrapped sweet taste material is disclosed.Described caffeine or other one or more active matters can be extraly by various encapsulant encapsulates, and described encapsulation agent comprises triglycerides, fatty ion exchange resin or other encapsulation agents arbitrarily.Can realize sealing by any known method, for example pass through spray shaping, the spraying cold quenching, cohesion, fluidized bed drying, absorption absorbs, and matrix is sealed, or any additive method.
Described solid composite may further include coolant agent as described above, the agent of warm flavor, or numb perverse dose.These local flavor things, coolant agent, the agent of warm flavor, perverse dose of fiber crops or the like can be encapsulated with caffeine or other active matters.Described solid central filler district can the described gum composition of complete filling the center, or it can partly fill the center of described gum composition.
Can become in the embodiment of liquid in some described solid central, described solid central can comprise the mixture of invertase and sucrose, and these invertases are done on sucrose in order to form liquid invert sugar, along with the time causes forming the liquid internal part.In some embodiments, described solid candy composition can be the fat with melting property, and described like this fat becomes liquid then for the solid melt under storage temperature under the manufacturing temperature.In some embodiments, described solid candy can comprise gelatin or the saccharose beads that liquid is filled, and described saccharose beads discharges liquid when breaking or rupture.
Known some active component has the offending taste of the user of allowing, and is called peculiar smell " off-taste ".Usually, this peculiar smell is the bitter taste of described active matter.In view of this peculiar smell, the composition in described candy district can provide enough taste masking effects, and suitable user exempts from disturbing of described active component peculiar smell.Described taste-masking effect can be sheltered making of composition by the taste of any appropriate and is used for realizing, for example fat.
As used herein, term " fat " refers to any matrix material, and can be solid or liquid.Suitable fat can comprise plant origin, those of animal origin, and composition thereof.Suitable plant fat can comprise soybean fat, cottonseed fat, corn fat, almond fat, peanut fat, sunflower fat, rapeseed fat, olive fat, palm fat, palm kernel fat, the mist ice grass grease fat, breast wood fruit fat, coconut fat, cocoa butter fat and composition thereof.To be understood that these plant fats can be as required by hydrogenation in various degree by those skilled in the art.Suitable animal tallow can comprise fat of dairy product, for example butter oil and butter.
The amount of the fat in the described candy district can provide enough tastes to shelter level.Can expect the fat of any amount.Described fat can exist with the amount of about 1-15% of described candy district weight.In some embodiments, the amount of the fat in the described candy district is about 2-14%, about 3-13%, about 4-12%, about 5-11%, about 6-10% or about 7-9%.In other embodiments, on the whole, described fat can exist with the amount of about 0.5-10% of described chewing gum composition weight.Also wanting in other embodiments, the amount of the fat in the described chewing gum composition is about 1-9%, about 1.5-8%, about 2-7%, about 2.5-6%, about 3-5% or about 3.5-4% on the whole.
In some embodiments, emulsifying agent can be added to described candy district.Suitable emulsifying agent can include, but not limited to lecithin or other phosphatide, poly-castor oil acid polyglycerol ester; monoglyceride, two glyceride, stearoyl (steoryl) sodium lactate, the citrate of single glycerine and two glycerine; the distillation monoglyceride, acetylated monoglyceride, C
16-C
20The mono-and diglycerides of aliphatic acid, glycerin monostearate for example, triacetyl glycerine, aliphatic acid, sucrose ester, and combination.
Described feature and advantage show more fully that by following embodiment described embodiment limits the present invention for the purpose of example is provided by any way and should not be construed as.
Embodiment
Embodiment 1:
Table 1: chewing gum composition
Component |
% weight |
Matrix sugar bodying agent |
??25.0 |
Lecithin |
??0.5 |
Sugar |
??61.5 |
High-fructose corn syrup |
??7.0 |
Glycerine |
??0.5 |
Peppermint local flavor thing blend |
??2.45 |
Free APM |
??0.07 |
Component |
% weight |
Free ACE-K |
??0.01 |
Entrapped APM |
??2.56 |
Entrapped ACE-K |
??0.51 |
Chewing gum composition is according to preparation of compositions described in the above table 1.
Table 2: anti-nougat solid candy composition of chewing
Component |
% weight |
Sugar |
??41.6 |
High-fructose corn syrup |
??41.6 |
Gelatin |
??1.89 |
Water |
??2.84 |
Fat |
??3.02 |
Caffeine |
??7.56 |
The local flavor thing |
??1.51 |
Anti-nougat confectionery composition of chewing is according to preparation of compositions described in the above table 2.
Chewing gum composition by at first under about 90 ℃ temperature fusion matrix sugar bodying agent prepare.In case fusion, filler is added in the bodying agent, and stirs about 0.5min.With sugar, high-fructose corn syrup and glycerine add, and mix 3.5min simultaneously then.Mixed and the interpolation of peppermint local flavor thing blend mixes 3.5min simultaneously.Add free APM, free ACE-K, entrapped APM and entrapped ACE-K, and mix 3.5min.Temperature is dropped to about 43 ℃.
Anti-nougat center filler compositions of chewing prepares by at about 60 ℃ gelatin being dissolved in the water.Sugar and corn syrup are heated to boiling in the pot that separates separately (pot) lining under about 130 ℃.Caffeine little by little is mixed in the infusion sugar, and adds gelatin solution when mixture reaches about 93 ℃.With fatty fusion, and be added in the batch of material lentamente with the local flavor thing.Mixture is transferred in the cooler pan.
Utilize routine techniques that resulting compound is shaped to the net shape of expectation then, routine techniques except other routine techniques, for example, is extruded, roll and cut into rod, and moulding becomes piller, and coats alternatively subsequently, perhaps tablet forming.When chewing, described product realizes providing the effect of a dosage caffeine, keeps the taste and the quality of pleasant simultaneously.
Embodiment 2:
Table 3: chewing gum composition
Component |
% weight |
Matrix sugar bodying agent |
??25.0 |
Lecithin |
??0.5 |
Sugar |
??61.5 |
High-fructose corn syrup |
??7.0 |
Glycerine |
??0.5 |
Sweet taste peppermint local flavor thing blend |
??3.31 |
Free APM |
??0.07 |
Free ACE-K |
??0.01 |
Entrapped APM |
??2.56 |
Entrapped ACE-K |
??0.51 |
Chewing gum composition is according to preparation of compositions described in the above table 1.
Table 4: anti-nougat center filler compositions of chewing
Component |
% weight |
Sugar |
??41.59 |
High-fructose corn syrup |
??41.59 |
Gelatin |
??1.89 |
Water |
??2.84 |
Fat |
??3.02 |
Caffeine |
??7.56 |
Component |
% weight |
The local flavor thing |
??1.51 |
Anti-nougat confectionery composition of chewing is according to preparation of compositions described in the above table 2.
Chewing gum composition is by at first preparing at about 90 ℃ temperature fusion matrix sugar bodying agent.In case fusion, filler are added in the described bodying agent, and stir about 0.5min.Sugar, high-fructose corn syrup and glycerine are added then, mix 3.5min simultaneously.Mix and interpolation sweet taste peppermint local flavor thing blend, mix 3.5min simultaneously.Then temperature is reduced to about 48 ℃, and adds free APM subsequently, free ACE-K, entrapped APM and entrapped ACE-K, and mix 3.5min.Temperature is dropped to about 43 ℃.
Anti-nougat center filler compositions of chewing prepares by at about 60 ℃ gelatin being dissolved in the water.Sugar and corn syrup are heated to boiling under about 130 ℃ in the pot that separates separately.Caffeine little by little is mixed in the described infusion sugar, and adds gelatin solution when described mixture reaches about 93 ℃.Fat is melted, and is joined in the batch of material with the local flavor thing lentamente.Mixture is transferred in the cooler pan.
Utilize routine techniques that resulting compound is shaped to the net shape of expectation then, routine techniques except other routine techniques, for example, is extruded, roll and cut into rod, and moulding becomes piller, and coats alternatively subsequently or tablet forming.When chewing, described product realizes providing the effect of a dosage caffeine, keeps the taste and the quality of pleasant simultaneously.
Multi-region chewing gum embodiment
The following examples have illustrated some embodiments, matrix sugar bodying agent wherein, and chewing gum, or the both is added in the sugar or sugar-free solid candy composition with active matter.In certain embodiments, described solid candy composition comprises hydrophilic colloid, gelatin for example, and described hydrophilic colloid can provide the benefit of quality.In some embodiments, described solid candy composition comprises fat, and described fat can provide taste to shelter benefit.
Embodiment 10-50 shown in the table 1 is at matrix sugar bodying agent composition, and the embodiment 100-140 shown in the table 2 is at chewing gum composition.Then, described matrix sugar bodying agent and chewing gum composition can assign to form multi-region chewing gum together with the elastomer group of embodiment 200-240 shown in table 3 and 4 and 300-340.
Table 1
Embodiment 10-50; Matrix sugar bodying agent
|
|
|
|
|
|
Quality adjusting control agent (polymer) |
|
|
|
|
|
Polyvinyl acetate |
??5-15 |
??10-30 |
??15-25 |
??10-20 |
??20-30 |
|
|
|
|
|
|
Emulsifying agent |
??3-8 |
??5-10 |
??3-8 |
??0-2 |
??2-5 |
Glyceryl triacetate |
|
|
|
|
|
Glycerin monostearate |
|
|
|
|
|
Lecithin |
|
|
|
|
|
|
|
|
|
|
|
Filler |
|
|
|
|
|
Calcium carbonate |
??30-40 |
??0-10 |
??10-20 |
|
|
Talcum |
|
|
|
??10-20 |
??10-20 |
|
|
|
|
|
|
Add up to: |
??100 |
??100 |
??100 |
??100 |
??100 |
Processing: elastomer is added in the pot of preheating, and mixes the temperature that reached 190F in 3 minutes up to described agglomerate under high shear.Described filler is added then and mixed 3 minutes.Next, rosin ester is added and is continued mixing 5 minutes lentamente.Then, following material is added in turn, continues simultaneously to mix: polyvinyl acetate, wax, hydrogenated vegetable oil and emulsifying agent.Final agglomerate was by blend and about 30 minutes.Final temperature should be in the range from 160F to 210F.The matrix sugar bodying agent of finishing then can be discharged from described pot, and is placed in the coating pan (coated pan).Extensions (de-panning) is preceding is allowed to cooling and hardens going to roll for the described matrix sugar bodying agent of finishing.
Table 2
Embodiment 100-140; Chewing gum
Composition |
??100 |
??110 |
??120 |
??130 |
??140 |
Sucrose |
??30%-70% |
??0 |
??25%-50% |
??30%-70% |
??0 |
Corn syrup |
??10%-30% |
??0 |
??10-30% |
??10%-30% |
??0 |
Hydrogenated starch hydrolysate |
??0 |
??0.1-10% |
??0.1-10% |
|
??0.1-10% |
D-sorbite |
??0 |
??30%-70% |
??10%-30% |
|
??30%-70% |
Antierythrite |
??0 |
??0-20% |
??1%-10% |
|
??0-20% |
Xylitol |
??0 |
??0-20% |
??0-10% |
|
??0-20% |
Maltitol |
??0 |
??0-60% |
??0-30% |
|
??0-60% |
Isomalt |
??0 |
??0-20% |
??0-10% |
|
??0-20% |
Matrix sugar bodying agent from embodiment 10 |
??40%-60% |
|
|
|
|
Matrix sugar bodying agent from embodiment 20 |
|
??10%-30% |
|
|
|
Matrix sugar bodying agent from embodiment 30 |
|
|
??20%-50% |
|
|
Matrix sugar bodying agent from embodiment 40 |
|
|
|
??30%-60% |
|
Matrix sugar bodying agent from embodiment 50 |
|
|
|
|
??10%-30% |
Composition |
??100 |
??110 |
??120 |
??130 |
??140 |
Glycerine |
??0.1-1% |
??0.1-15% |
??0.1-5% |
??0.1-1% |
??0.1-1% |
Lecithin |
??0.1-10% |
??0.1-10% |
??0.1-10% |
??0.1-10% |
??0.1-10% |
Vegetable oil |
??5-15% |
??0.1-5% |
??0.1-10% |
??0.1-5%% |
??5-15% |
The local flavor thing |
??2-5% |
??0.1-3% |
??0.1-3% |
??0.1-3% |
??2-5% |
Acid |
??0.1-10% |
??0.1-10% |
|
??0.1-10% |
|
Pigment |
??0.001-0.2% |
??.001-0.2% |
??0.001-0.2% |
??0.001-0.2% |
??0.001-0.2% |
Free sweet taste material |
|
??0.1-0.5 |
??0.01%-0.2 |
|
??0.01%-0.2 |
Entrapped sweet taste material |
|
??0.5-7% |
??0.1%-2% |
|
??0.1%-2% |
Cool flavor compound |
??0.01-0.25% |
??0.1-0.25% |
??0.1-0.25% |
??0.01-0.25% |
??0.1-0.25% |
Processing: matrix sugar bodying agent is placed in the blender, and is heated to about 65 ℃ temperature.Liquid and the mixed interpolation of pulverous increment sweet taste material, and mix up to the agglomerate of realizing homogeneous.Comprise the local flavor thing, acid, the less composition of pigment and sweet taste material was added during last 5-10 minute that mixes.The batch of material that is thoroughly mixed is discharged from from described blender then.
Table 3
Embodiment 200-240; Multi-region chewing gum with matrix sugar bodying agent and solid candy
Composition |
??200 |
??210 |
??220 |
??230 |
??240 |
The solid candy composition |
|
|
|
|
|
Sucrose |
??30%-60% |
|
??30%-50% |
|
??30%-60% |
Corn syrup |
??60%-30% |
|
??30%-50% |
|
??60%-30% |
Water |
??10%-20% |
??10-30% |
??10-25% |
??10-30% |
??10%-20% |
Fat |
??0%-8% |
|
??0%-8% |
|
??0%-8% |
Hydrophilic colloid |
|
|
??0%-8% |
|
??0%-8% |
Lecithin |
??0%-0.8% |
??0%-1% |
??0%-1% |
|
??0%-1% |
??GMS |
??0%-0.8% |
??0%-1% |
??0%-1% |
|
??0%-1% |
Hydrogenated starch hydrolysate |
|
??0%-10% |
|
|
|
D-sorbite |
|
??0%-60% |
|
|
|
Antierythrite |
|
|
??0%-15% |
??0%-25% |
|
Xylitol |
|
|
|
??0%-60% |
|
Maltitol |
|
|
|
??0-60% |
|
Composition |
??200 |
??210 |
??220 |
??230 |
??240 |
Isomalt |
|
??0%-80% |
??0%-30% |
|
|
Sweet mellow wine |
|
??0-25% |
|
|
|
The local flavor thing |
??0.5%-5.0% |
??0.3%-2.5% |
??0.3%-2.5% |
??0.3%-2.5% |
??0.3%-3.0% |
Acid |
??0.1%-3.0% |
|
??0.1%-3.0% |
|
??0.1%-3.0% |
Pigment |
??0%-0.2% |
??0%-0.2% |
??0%-0.2% |
??0%-0.2% |
??0%-0.2% |
Free sweet taste material |
|
??0.1%-0.5% |
??0.01-0.2% |
??0.01-0.2% |
|
Entrapped sweet taste material |
|
??0.5%-7% |
??0.1%-2% |
??0.1%-2% |
??0.1%-2% |
Cool flavor compound |
??0.01-0.25% |
|
??0.01-0.25% |
|
??0.01-0.25% |
Caffeine |
??0.5-5% |
|
|
|
|
Entrapped caffeine |
|
??0.5-10% |
|
|
|
Green-tea extract |
|
|
??0.1-5% |
|
|
Epigallo-catechin gallate (EGCG) |
|
|
|
??0.1-5% |
|
Composition |
??200 |
??210 |
??220 |
??230 |
??240 |
Vitamin B6 |
|
|
|
|
??0.001-1% |
Elastomeric component: |
|
|
|
|
|
Matrix sugar bodying agent from embodiment 10 |
??5%-40% |
|
|
|
|
Matrix sugar bodying agent from embodiment 20 |
|
??5%-40% |
|
|
|
Matrix sugar bodying agent from embodiment 30 |
|
|
??5%-40% |
|
|
Matrix sugar bodying agent from embodiment 40 |
|
|
|
??5%-40% |
|
Matrix sugar bodying agent from embodiment 50 |
|
|
|
|
??5%-40% |
Candy is made processing:
The prescription part of weighing sugar, corn syrup, D-sorbite, xylitol, antierythrite, maltitol, mannitol, the pure and mild water of isomaltoketose.
Begin to boil.
Add fat, lecithin, GMS when boiling, and mix
Boil the infusion temperature
Add hydrophilic colloid in the slurry form of dissolving in advance
Add local flavor thing, acid and pigment
Add active matter and thoroughly mixing
Multi-region chewing gum is made processing:
Heat matrix sugar bodying agent up to the melt molding multi-region chewing gum, by:
1. co-blended
A. the solid candy composition is mixed at 70 ℃-110 with matrix sugar bodying agent
B. on the conveyer belt or tempering on the platform (temper)
C. draw (Pull)/rub; Perhaps
2. fill at the center
A. with the bodying agent coextrusion of solid candy composition and matrix sugar so that described solid candy composition forms an interior zone; Perhaps
B. with the sugar bodying agent coextrusion of solid candy composition and matrix so that described matrix sugar bodying agent forms an interior zone
By chain type mould, revolving die, feed roller or cutting and parcel moulding
Described composition also can comprise the shape of walking stick sugar, rod, pipe, sheet or the like with the confectionery technological forming with generation.
Table 4
Embodiment 300-340; Multi-region chewing gum with chewing gum and/or matrix sugar bodying agent and solid candy
Chewing gum from embodiment 100 |
??50%-80% |
|
|
|
|
Chewing gum from embodiment 110 |
|
??50%-80% |
|
|
|
Chewing gum from embodiment 120 |
|
|
??50%-80% |
|
|
Chewing gum from embodiment 130 |
|
|
|
??48%-75% |
|
Chewing gum from embodiment 140 |
|
|
|
|
??48%-75% |
|
|
|
|
|
|
Add up to |
??100 |
??100 |
??100 |
??100 |
??100 |
Candy is made processing:
The prescription part of weighing sugar, corn syrup, D-sorbite, xylitol, antierythrite, maltitol, mannitol, the pure and mild water of isomaltoketose.
Begin to boil.
Add fat, lecithin, GMS when boiling, and mix
Boil the infusion temperature
Add hydrophilic colloid in the slurry form of dissolving in advance
Add local flavor thing, acid and pigment
Add active matter and thoroughly mixing
Multi-region chewing gum is made processing:
Heating matrix sugar bodying agent is up to fusion
Mix into chewing gum
The moulding multi-region chewing gum, by:
1. co-blended
A. solid candy composition and matrix sugar bodying agent and/or chewing gum are mixed for-110 times at 70 ℃
B. on the conveyer belt or tempering on the platform
C. draw/rub; Perhaps
2. fill at the center
A. with solid candy composition and matrix sugar bodying agent and/or chewing gum coextrusion so that described solid candy composition forms an interior zone; Perhaps
B. with solid candy composition and matrix sugar bodying agent and/or chewing gum coextrusion so that described matrix sugar bodying agent and/or chewing gum form an interior zone
On the conveyer belt or tempering on the platform
Draw/rub
Seal moulding by chain type mould, revolving die, feed roller or cutting and parcel
Described composition also can comprise walking stick sugar/rod/pipe/sheet or the like shape with generation with the confectionery technological forming.
Ensuing serial embodiment comprises the embodiment of soft sweets composition at described multi-region chewing gum.Embodiment 400-470 is at various soft sweets composition, and the embodiment 500-570 shown in the table 5 is at the multi-region chewing gum composition that comprises those soft sweets compositions.
Embodiment 400-creme caramel soft sweets
Water 9.43%w/w
White granulated sugar 14.12%
Brown sugar 14.12%
Dextrose syrup 20-25%
Condensed milk 25.73%
Hydrogenated vegetable fat 11.29%
Glycerin monostearate 0.71%
Salt 0.44%
Caffeine 1-10%
Described multiple composition is mixed to together, and slowly heats up to thorough dissolving and mixing.Continue heating and mix up to reaching to 118 ℃ of soft creme caramels, to 121 ℃ of medium creme caramels, and to the final temperature of 128 ℃ of hard card Bill Rammell sugar.Described agglomerate is discharged from precooker and cooling then, cutting and parcel.During cooling caffeine can be sneaked into.
The strange sugared soft sweets of embodiment 410-method
Condensed milk 41.36%w/w
Butter 11.69%
Granulated sugar 10-25%
Semi sweet chocolate 25.85%
Dextrose syrup 1.03%
Vanilla 0.42%
Epigallo-catechin gallate (EGCG) (EGCG) 0.5-10%
Condensed milk, sugar and butter are incorporated in the steam assorted pot, and add thermal agitation and reach 150F up to temperature.During this blend step, add vanilla.Continue to heat the temperature that reaches 238F up to agglomerate, turn off steam, and add chocolate powerful the stirring at this temperature spot.Next, stir interpolation dextrose syrup down.Described agglomerate stirs down, and cooling reaches the temperature of 180-190F up to it.During cooling EGCG is sneaked into.Described agglomerate is poured on the marble slab then, and processing is up to the crystallization/quality that reaches expectation.The strange sugar of described method is cut then and wraps up.
Embodiment 420-truffle chocolate soft sweets
Side dawn sugar 70-75%w/w
Cocoa slurry 8.80%
Condensed milk 17.70%
Vanilla to taste
Vitamin B6 0.001-1%
Side's dawn sugar 60-63 ℃ of following fusion, and is stirred cocoa slurry in the square dawn sugar of fusion.In the container that separates, condensed milk is heated to 93 ℃, stirs simultaneously preventing to burn, and keeps 15 minutes.Next, the milk side of the being added to dawn sugar/cocoa pulp mixture of heating, and thoroughly mix.Vitamin B6 is added and thoroughly mixes.Truffle chocolate (truffle) agglomerate then can be by moulding and packing.
Embodiment 430-cotton soft sweets soft sweets
Gelatin 2.03%w/w
Water 9.44%
Egg white 0.67%
Water 4.06%
Sugar 30-40%
Dextrose syrup 16.25%
Water 13.50%
Invert sugar 16.13%
The local flavor thing to taste
Entrapped caffeine 0.5-5%
Described gelatin is immersed in the water of first amount, makes its dissolving by the described mixture of slow intensification then.In the container of opening in a minute, described egg white similarly is immersed in the water of second amount, and makes its dissolving by the described mixture of slow intensification.Then that gelatin and egg white solution is admixed together.Dividually, sugar, the water of dextrose syrup and the 3rd amount is heated together so that dissolve, and boils 112 ℃ subsequently.Invert sugar is added to the sugar solution of infusion then, and is cooled to 71 ℃.The end of entrapped caffeine cooling cycle nearly is added.Then described sugar is added in the gelatin/egg white of mixing, and be inflated to 0.40 to 0.50 density.The agglomerate that is inflated then by moulding in starch, and before the demoulding and parcel 27 ℃ dry 16 to 24 hours down.
The anti-nougat soft sweets of chewing of embodiment 440-
Egg white 0.37%w/w
Water 3.13%
Sugar 6.59%
Water 2.00%
Sugar 34-48%
Dextrose syrup 36.63%
Water 14.65%
Dextromethorphan 0.0001-2%
Egg white is dissolved in the water of first amount, the sugar with first amount is dissolved in the water of second amount simultaneously.Described egg white and sugar solution are mixed together and inflate.In the container of opening in a minute, the sugar of second amount is dissolved in the water of the 3rd amount, and corn syrup is added mixing.This sugar solution is boiled 141 ℃ then.Described infusion sugar solution is added to described in beating egg white/sugar solution then with the thread form.Described agglomerate is poured on the cooling bench then, described agglomerate be cut and parcel wrap up in before described dextromethorphan add on this cooling bench.
Embodiment 450-starch jelly sugar soft sweets
Sugar 15-20%w/w
Dextrose syrup 23.34%
Invert syrup 4.50%
Water 23.63%
Rare starch 6.04% that boils
Water 23.63%
Citric acid 0.02%
The local flavor thing to taste
Pigment on demand
That takes extract 0.0001-10% melon
Sugar is dissolved in the water of first amount, and is mixed together, and boil to boiling with dextrose syrup and invert sugar.In the container of opening in a minute,, starch prepares starch slurry by being mixed with the water (cold) of second amount.Described starch slurry adds the described sugar solution that is seething with excitement to thread, and mixes.The mixture infusion reaches the solid of 76-78% up to it.That takes extract to add described melon when mixture cools off.Then with described agglomerate moulding in starch, and the demoulding and the parcel before, allow agglomerate solidify (set up).
Embodiment 460-gelatin jelly sugar soft sweets
Sugar 38-42%w/w
Dextrose syrup 30.25%
Water 16.80%
Gelatin 5.37%
Water 5.37%
Citric acid 0.84%
Water 0.84%
The local flavor thing to taste
Pigment on demand
Cactus (Hoodia) extract 0.0001-5%
Sugar and dextrose syrup are dissolved in the water of first amount together, and boil to 115 ℃.Dividually, gelatin is immersed in the water of second amount, and heats up subsequently with the dissolving gelatin.Sugar solution is cooled to 80 ℃, and gelatin is added in the described sugar.At last, add citric acid (being dissolved in the water of the 3rd amount) to described agglomerate with local flavor thing and pigment and Radix et Caulis Opuntiae Dillenii extract.Subsequently, product is molded to allow curing.In case candy has cured, it can be by the demoulding and packing.
The anti-candy of chewing of embodiment 470-sugar-free
Maltitol 25-35%w/w
Polydextrose 25-35%
Soluble Fiber 5-10%
Sucralose 0.001-0.05%
Vegetable oil 3-8%
Lecithin 0.5-1.2%
Gelatin 1-5%
Food acidity agent 5-15%
Food pigment on demand
Local flavor thing 0.5-2.3%
Maltitol side's dawn sugar 1.5-9%
Omega-fatty acid 0.01-10%
With maltitol, the water of polydextrose and Soluble Fiber and capacity mixes to dissolve described solid.Then, when vegetable oil and Sucralose are added, described mixture is heated to boiling.Continue heating up to the temperature that reaches 130 ℃.Along with stopping heating, add the gelatin of described pre-hydration, acid, omega-fatty acid and pigment, and mixed one minute.Described mixture is transferred to the tempering platform that is set at 65F, admix described local flavor thing and side's dawn sugar herein.Then, described mixture can be drawn up to obtaining desired quality.
Table 5
Embodiment 500-560; Have soft sweets and boil the candy matrix sugar of saccharide component
Isomalt |
|
??5-10 |
|
|
??5-30 |
|
|
??3-8 |
Soft sweets from embodiment 400 |
??20-80 |
|
|
|
|
|
|
|
Soft sweets from embodiment 410 |
|
??10-20 |
|
|
|
|
|
|
Soft sweets from embodiment 420 |
|
|
?25-50 |
|
|
|
|
|
Soft sweets from embodiment 430 |
|
|
|
?10-70 |
|
|
|
|
Soft sweets from embodiment 440 |
|
|
|
|
??30-90 |
|
|
|
Soft sweets from embodiment 450 |
|
|
|
|
|
??30-90 |
|
|
Soft sweets from embodiment 460 |
|
|
|
|
|
|
?30-90 |
|
Soft sweets from embodiment 470 |
|
|
|
|
|
|
|
??20-80 |
Elastomeric component |
|
|
|
|
|
|
|
|
Matrix sugar bodying agent from embodiment 10 |
|
|
?30-50 |
|
|
|
|
|
Matrix sugar bodying agent from embodiment 20 |
|
??50-10 |
|
|
|
??50-10 |
|
|
Isomalt |
|
??5-10 |
|
|
??5-30 |
|
|
??3-8 |
Matrix sugar bodying agent from embodiment 30 |
|
|
|
|
|
|
|
??30-70 |
Matrix sugar bodying agent from embodiment 40 |
|
|
|
|
??30-70 |
|
|
|
Matrix sugar bodying agent from embodiment 50 |
??15-70 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Chewing gum from embodiment 100 |
??5-8 |
|
|
|
|
|
|
|
Chewing gum from embodiment 110 |
|
|
|
|
|
|
?25-75 |
|
Chewing gum from embodiment 120 |
|
|
|
?30-90 |
|
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|
|
Chewing gum from embodiment 130 |
|
|
|
|
|
??10-70 |
|
|
Chewing gum from embodiment 140 |
|
??15-70 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Add up to |
??100 |
??100 |
?100 |
?100 |
??100 |
??100 |
?100 |
??100 |
Candy matrix sugar is made processing:
Heating matrix sugar bodying agent (if any) is up to fusion
Soft sweets and the matrix sugar bodying agent (if any) that active matter is arranged are mixed down at 70-110 ℃
1. co-blended
A. the soft sweets composition is mixed under 70-110 ℃ with matrix sugar bodying agent and/or chewing gum
B. on the conveyer belt or tempering on the platform
C. draw/rub; Perhaps
2. fill at the center
A. with soft sweets composition and matrix sugar bodying agent and/or chewing gum coextrusion, make described solid candy composition form interior zone like this;
B. with solid candy composition and matrix sugar bodying agent and/or chewing gum coextrusion, make described matrix sugar bodying agent and/or chewing gum form interior zone like this
Mix into chewing gum (if any)
On the conveyer belt or tempering on the platform
Draw/rub
By chain type mould, revolving die, feed roller or cutting and parcel moulding
A series of embodiment comprises the embodiment of coatings at the multi-region chewing gum composition down.
The embodiment that is coated
Coating can relate to the outer surface of handling confectionery composition.Can use diverse ways to handle described outer surface and use coated composition.These methods can comprise rolls extension, extrudes, soaks and hang and rotary drum coats (tumble coating), foldingly coats (fold coating), breading, mixes sand, and around confectionery composition, use coated composition, when it passes even bar device (rope sizer) of material string size or batch of material former (batch former).
Embodiment 1010-has the multi-region chewing gum of hard coatings
Step: as in embodiment 500, preparing multi-region chewing gum, and with the shape of single formation of lots for expectation, for example shape of pillow or ball.Described single piece is loaded in coating pan then, and cycles through repeatedly with rotary drum (tumbling) and dry air the isomalt solution spraying is used described isomalt dressing to the candy gum pieces.With coolant agent be added into the isomalt syrup once or more times use to incorporate described coatings into.In case desired dressing amount realizes, the candy gum pieces of described coating is shifted out from described coating pan.
Embodiment 1011-soaks the multi-region chewing gum of extension with boiled goods
Has the candy gum composition of hanging the food acidity agent in the composition soaking |
|
|
Composition |
Percetage by weight |
|
|
From the multi-region chewing gum of embodiment 540, solid candy district described in this embodiment and described chewing gum district mix |
??67.00 |
|
|
Isomalt |
??32.50 |
The food acidity agent |
??0.50 |
|
|
Add up to |
??100.00 |
Step: as in embodiment 540, preparing multi-region chewing gum, and with the shape of single formation of lots for expectation, for example shape of rod or sheet.Described single piece is placed to the transmission net element then, and passes machine (bottomer) at the bottom of the paste that is mounted with the isomalt syrup.The piece of being stuck with paste the end is vibrated removing excessive syrup, and can be transmitted through soak on-hook before through drying steps, soaking on-hook place, by the piece of back cover by adding the isomalt syrup curtain (curtain) of food acidity agent.Excessive isomalt syrup blows away with air or shakes off with vibration, and the described then piece that is soaked extension was dried before packing.
Embodiment 1012-multi-region chewing gum hard candy shell
Step:, and be loaded in first feed hopper of many hoppers extruder as preparation candy matrix sugar in embodiment 200.Sugar and corn syrup mix with the water of capacity to dissolve described sugar, boil the water capacity of expectation then.When it cooled off, the second local flavor thing was added to described sugar/corn syrup mixture, and the sugar/corn syrup of seasoning is loaded in second feed hopper of described extruder.Sugar/the corn syrup mixture of described candy matrix sugar and seasoning by coextrusion to form final product.