CN101878819B - Baby formula milk powder containing adiponectin and preparation method thereof - Google Patents
Baby formula milk powder containing adiponectin and preparation method thereof Download PDFInfo
- Publication number
- CN101878819B CN101878819B CN2010102307196A CN201010230719A CN101878819B CN 101878819 B CN101878819 B CN 101878819B CN 2010102307196 A CN2010102307196 A CN 2010102307196A CN 201010230719 A CN201010230719 A CN 201010230719A CN 101878819 B CN101878819 B CN 101878819B
- Authority
- CN
- China
- Prior art keywords
- milk powder
- adiponectin
- premix
- vitamin
- baby formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Dairy Products (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to baby formula milk powder containing adiponectin and a preparation method thereof. The baby formula milk powder containing the adiponectin comprises the following components: 100 grams of raw material milk powder, 0.3 to 1.0 gram of vitamin premix, 0.8 to 2.0 grams of mineral premix, 0.01 to 0.10 gram of adiponectin, 0.01 to 0.05 gram of nucleotide, 0.2 to 0.8 gram of docosahexaenoic acid and 0.3 to 1.0 gram of arachidonic acid. The invention also comprises the preparation method of the baby formula milk powder containing the adiponectin. The baby formula milk powder of the invention can sensitize the effects of baby insulin, better regulate the body energy metabolism and reduce the risks of obesity, diabetes, coronary heart disease and the like after babies grow up, also comprises vitamins, minerals and other nutrient components, which are necessary for the babies in daily life, and can meet comprehensive nutritional requirements of the babies.
Description
Technical field
The present invention relates to a kind of baby formula milk powder and preparation method thereof, especially relate to a kind of baby formula milk powder that contains adiponectin and preparation method thereof.
Background technology
[0002]Breast milk be the baby grow up unique the most naturally, the safest, most complete natural food.Breast milk not only contains the various nutrients of infants growth and development needs, and contains multiple bioactie agent, can influence breast-feeding infant intestines and stomach, nerve, immune development, is the extension of placental function behind the baby due.Existing many recently scholars propose: baby's early nutrition is the important stimulus factor that causes the procedural change of adulthood metabolism; Can regulate and control the cardiovascular health of adult, human body is anti-infective and antianaphylactic ability and neural function, can also regulate and control autoimmune disease and the fat generations of adult such as type i diabetes, inflammatory bowel disease.Research shows that the probability that Chronic Non-Communicable Diseases such as obesity, diabetes, cardiovascular and cerebrovascular diseases took place after breast-feeding infant was grown up is lower.
For lacking special babies such as milk, premature or low birth weight infant, owing to can not sucking reason such as breast milk, a lot of mothers breast milk of having to abandon feeding.At this moment,, milk (or goat milk, soybean etc.) composition is changed, add various vitamins and trace element again, meet the baby digests and assimilates just becomes breast milk with the formula milk of nutritional need best substitute to greatest extent through simulation breast milk nutritional labeling.Although the production technology of various baby milk powders is being updated, only be nutritional labeling near breast milk, and aspect immunologic facilitation, still have weak point.Because existing various baby formula milk powders only are simulation breast milk nutritional labelings, lack the immunologic function factor and various growth factor that human milk (week of particularly giving a birth is with interior people's colostrum) is contained.And these active components reach the health after extremely growing up for regulating infant physical growth and growth, and are all significant.
Summary of the invention
The object of the present invention is to provide a kind of immunologic function good, can regulate the human body energy metabolism better, that reduces that child grows up that fat and diabetes, coronary heart disease equivalent risk take place in the back contains baby formula milk powder of adiponectin and preparation method thereof.
The objective of the invention is to realize through following technical scheme.
The present invention's the infant who contains adiponectin joins milk powder, comprises following component: raw material milk powder 100g, vitamin premix 0.3-1.0g, mineral substance premix 0.8-2.0g, adiponectin 0.01-0.10g, nucleotides 0.01-0.05g, DHA (DHA) 0.2-0.8g; ARA (arachidonic acid) 0.3-1.0g.
Preferred following component of said raw material milk powder and percentage by weight are mixed and form: desalted whey powder 32-50%; Vegetable oil 20-30%; Skimmed milk power 13-22%; Lactose 2-12%; Lecithin 0.2-1.0%;
Preferred following component of said vitamin premix and percentage by weight are mixed and form: L-SODIUM ASCORBATE 15-20%, vitamin E 40-50%, choline bitartrate 7-10%, inositol 6-9%, taurine 5-8%, nicotinic acid 1-2%, riboflavin 0.1-0.2%, Cobastab
60.1-0.2%, Cobastab
120.0001-0.0005%, biotin 0.003-0.008%, folic acid 0.02-0.05%, calcium pantothenate 0.5-1.0%, Vitazyme A 3-7%, vitamin K
10.1-0.3%, lactose 5-15%, beta carotene 0.03-0.15%;
Preferred following component of said mineral substance premix and percentage by weight are mixed and form: tricresyl phosphate hydrogen calcium 30-35%, potassium chloride 20-25%, magnesium sulfate 17-20%, ferric pyrophosphate 2-3%, zinc sulfate 0.5-0.8%, copper sulphate 0.05-0.1%, KI 0.002-0.008%, potassium dihydrogen phosphate 5-10%, sodium dihydrogen phosphate 5-10%, lactose 5-15%.
Said adiponectin can be natural adiponectin or reorganization adiponectin.Preferred natural adiponectin.
Said skimmed milk power can be skim milk powder or goat milk powder.
The preparation method of the present invention's the baby milk powder that contains adiponectin; May further comprise the steps: the raw material milk powder of vitamin premix, mineral substance premix, adiponectin, nucleotides, DHA, ARA and predetermined weight proportioning 4-10% is poured into carried out the one-level premix in the three-dimensional mixer earlier, the premix time is 15-25min; Then the material behind the one-level premix is crossed behind the 30-40 mesh sieve to add with remaining raw material milk powder and carry out secondary in high-speed mixer and do and mix, rotating speed 35-45 commentaries on classics/min, time 80-100s mixes; Change at last and move the powder car, vacuumize the filling inert gas and pack.
The present invention's baby formula milk powder also can adopt other any suitable methods to carry out processing and manufacturing.
Research shows that adiponectin is the rho factor of the biologically active of one type of fatty emiocytosis.Lasting adiponectin that exists and bleeding of the umbilicus sugar, the insulin level relation of being proportionate in the breast milk point out it in the breast-feeding infant metabolism is grown, to have potential meaning and " sequencing of metabolism influences " at a specified future date.Related data shows, contains the adiponectin of 3.0 micrograms-367.1 microgram of having an appointment in every liter of breast milk.Adiponectin in the breast milk can be worked in coordination with the maturation that promotes the insulin of not degrading in the per os absorption stomach to arrive small intestine and stimulate enteron aisle; Can be through the aliphatic acid in promotion body skeletal muscle, liver and the cardiac muscle and the oxidation of glucose; The biosynthesis that suppresses fat and glucose reaches the regulation and control to energetic supersession, is the important regulatory factor in the regulated and control network of lipid-metabolism and glycaemic homeostasis of body.Human body adiponectin level can indicate the development of type ii diabetes and coronary heart disease, and shows the potentiality of anti-diabetic, antiatherosclerosis and inflammation in clinical testing.
The present invention is through adding adiponectin-a kind of adipocyte factor in baby formula milk powder; Overcome breast milk factor disappearance in the existing baby formula milk powder; The shortcoming of immunologic facilitation insufficiency of function; Can sensitization infant insulin effect, regulate the human body energy metabolism better, reduce the risk that obesity and diabetes, coronary heart disease etc. take place after child grows up.
Baby formula milk powder of the present invention also contains the daily necessary vitamin of infant, mineral matter and other nutritional labelings, can satisfy the comprehensive nutritional need of infant.
The specific embodiment
Below in conjunction with embodiment the present invention is described further.
Embodiment 1
Present embodiment prescription: raw material milk powder 100g (containing desalted whey powder 46%, vegetable oil 26%, skim milk 17.7%, lactose 10.6%, lecithin 0.7%); Mineral substance premix 1.2g, vitamin premix 0.68g; Nucleotides 0.03g; Adiponectin 0.02g; DHA 0.46g; ARA 0.52g.
Said vitamin premix is mixed by following component and forms: L-SODIUM ASCORBATE 17.4%, vitamin E 43.5%, choline bitartrate 8.7%, inositol 8.3%, taurine 7.2%, nicotinic acid 1.4%, riboflavin 0.13%, Cobastab
60.15%, Cobastab
120.0003%, biotin 0.006%, folic acid 0.035%, calcium pantothenate 0.7%, Vitazyme A 4.5%, vitamin K
10.12%, lactose 7.74%, beta carotene 0.1187%.
Said mineral substance premix is mixed by following component and forms: tricresyl phosphate hydrogen calcium 32%, potassium chloride 21.5%, magnesium sulfate 18.5%, ferric pyrophosphate 2.5%, zinc sulfate 0.72%, copper sulphate 0.068%, KI 0.005%, potassium dihydrogen phosphate 7.86%, sodium dihydrogen phosphate 6.88%, lactose 9.967%.
Production technology: the raw material milk powder of vitamin premix, mineral substance premix, adiponectin, nucleotides, DHA, ARA and predetermined weight proportioning 4-10% is poured into carried out the one-level premix in the three-dimensional mixer earlier, the premix time is 15-25min; Then the material behind the one-level premix is crossed behind 30 mesh sieves to add with remaining raw material milk powder and carry out secondary in high-speed mixer and do and mix, rotating speed 35-45 commentaries on classics/min, time 80-100s mixes; Change at last and move the powder car, vacuumize the filling inert gas and pack.
Embodiment 2:
Present embodiment prescription: raw material milk powder 100g (containing desalted whey powder 47%, vegetable oil 25%, skim milk 17.8%, lactose 9.4%, lecithin 0.8%); Mineral substance premix 1.53g, vitamin premix 0.86g; Nucleotides 0.026g; Adiponectin 0.05g; DHA 0.52g; ARA 0.65g.
Said vitamin premix is mixed by following component and forms: L-SODIUM ASCORBATE 16.8%, vitamin E 45.2%, choline bitartrate 8.3%, inositol 7.2%, taurine 6.1%, nicotinic acid 1.6%, riboflavin 0.12%, Cobastab
60.145%, Cobastab
120.0003%, biotin 0.0053%, folic acid 0.04%, calcium pantothenate 0.78%, Vitazyme A 6.5%, vitamin K
10.205%, lactose 6.9%, beta carotene 0.1044g.
Said mineral substance premix is mixed by following component and forms: tricresyl phosphate hydrogen calcium 33.5%, potassium chloride 23%, magnesium sulfate 18.3%, ferric pyrophosphate 2.46%, zinc sulfate 0.72%, copper sulphate 0.065%, KI 0.005%, potassium dihydrogen phosphate 7.88%, sodium dihydrogen phosphate 7.5%, lactose 6.57%.
Production technology: with embodiment 1.
Animal feeding test: following animal feeding test has been described among the present invention adiponectin to sensitization rat insulin effect, regulates the lipid-metabolism of body and the effect of glycaemic homeostasis.
1 materials and methods
1.1 experimental animal: the newborn SPF level of 7 ages in days SD rat
1.2 test method: 150 experimental animal rats are divided into three groups at random, 50 every group.Group 1 is the breast-feeding control group, and group 2 is for adding the formula milk enteral feeding group of adiponectin, the regular convention formula milk powder enteral feeding group of group 3 for not adding adiponectin.Each organizes independent feeding.The nursing time was 3 weeks.Respectively at the 0th day, 3 days, 7 days, 10 days, 14 days, 21 days after on-test mensuration rat body weight, plasma insulin level and blood sugar level situations of change.
2 results: in whole experiment; Add adiponectin formula milk enteral feeding group and breast-feeding group rat body weight situation, blood sugar level and insulin level, the equal no significant difference of insulin sensitivity index, adiponectin formula milk rat insulin benefit is added in prompting, the energetic supersession regulation and control can reach the breast-feeding level; Prolongation along with the time of nursing; Do not add adiponectin the regular convention formula milk powder enteral feeding group later stage rat body weight, blood sugar level, insulin level apparently higher than adding adiponectin formula milk enteral feeding group (P＜0.05); Insulin sensitivity index is starkly lower than and adds adiponectin formula milk enteral feeding group (P＜0.05), and the regular convention formula milk powder rat insulin sensitiveness that adiponectin is not added in prompting is obviously lower.See the following form
Table 1 respectively organize mouse changes of weight (
, g)
Annotate: compare with adding adiponectin milk powder group,
※P≤0.05
Table 2 respectively organize the mouse blood sugar level variation (
, mg%)
Annotate: compare with adding adiponectin milk powder group,
※P≤0.05
Table 3 respectively organize the mouse insulin level variation (
, mU/ml)
Annotate: compare with adding adiponectin milk powder group,
※P≤0.05
Table 4 is respectively organized the variation of mouse insulin sensitivity index (ISI)
Annotate: compare with adding adiponectin milk powder group,
※P≤0.05
3, conclusion: can judge that from above-mentioned test the baby formula milk powder that adds adiponectin is to sensitization insulin effect, the biosynthesis that suppresses fat and glucose has positive effect, can obtain the level near breast milk.
Claims (2)
1. baby formula milk powder that contains adiponectin; It is characterized in that, constitute: raw material milk powder 100g, vitamin premix 0.3-1.0g, mineral substance premix 0.8-2.0g, adiponectin 0.01-0.10g, nucleotides 0.01-0.05g, DHA 0.2-0.8g by following component; Arachidonic acid 0.3-1.0;
Said raw material milk powder is mixed by following component and percentage by weight and forms: desalted whey powder 32-50%; Vegetable oil 20-30%; Skimmed milk power 13-22%; Lactose 2-12%; Lecithin 0.2-1.0%; Each constituent content sum is 100%;
Said vitamin premix is mixed by following component and percentage by weight and forms: L-SODIUM ASCORBATE 15-20%, vitamin E 40-50%, choline bitartrate 7-10%, inositol 6-9%, taurine 5-8%, nicotinic acid 1-2%, riboflavin 0.1-0.2%, Cobastab
60.1-0.2%, Cobastab
120.0001-0.0005%, biotin 0.003-0.008%, folic acid 0.02-0.05%, calcium pantothenate 0.5-1.0%, Vitazyme A 3-7%, vitamin K
10.1-0.3%, lactose 5-15%, beta carotene 0.03-0.15%;
Said mineral substance premix is mixed by following component and percentage by weight and forms: tricresyl phosphate hydrogen calcium 30-35%, potassium chloride 20-25%, magnesium sulfate 17-20%, ferric pyrophosphate 2-3%, zinc sulfate 0.5-0.8%, copper sulphate 0.05-0.1%, KI 0.002-0.008%, potassium dihydrogen phosphate 5-10%, sodium dihydrogen phosphate 5-10%, lactose 5-15%.
2. preparation method who contains the baby formula milk powder of adiponectin according to claim 1; It is characterized in that; May further comprise the steps: the raw material milk powder of vitamin premix, mineral substance premix, adiponectin, nucleotides, DHA, arachidonic acid and predetermined weight proportioning 4-10% is poured into carried out the one-level premix in the three-dimensional mixer earlier, the premix time is 15-25min; Then the material behind the one-level premix is crossed behind the 30-40 mesh sieve to add with remaining raw material milk powder and carry out secondary in high-speed mixer and do and mix, rotating speed 35-45 commentaries on classics/min, time 80-100s mixes; Change at last and move the powder car, vacuumize the filling inert gas and pack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102307196A CN101878819B (en) | 2010-07-20 | 2010-07-20 | Baby formula milk powder containing adiponectin and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102307196A CN101878819B (en) | 2010-07-20 | 2010-07-20 | Baby formula milk powder containing adiponectin and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101878819A CN101878819A (en) | 2010-11-10 |
| CN101878819B true CN101878819B (en) | 2012-02-01 |
Family
ID=43051072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102307196A Active CN101878819B (en) | 2010-07-20 | 2010-07-20 | Baby formula milk powder containing adiponectin and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101878819B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102181437B (en) * | 2011-02-28 | 2012-11-14 | 东莞市畜牧科学研究所 | gAd gene of porcine adiponectin globular structural domain protein and protein coded by gAd gene and application of gAd gene |
| CN102524420A (en) * | 2011-12-23 | 2012-07-04 | 香港雙爱生物科技有限公司 | Dry process for the production of immune system milk powder |
| CN104757123A (en) * | 2015-04-03 | 2015-07-08 | 长沙素加营养品有限公司 | Full dry-mixing infant formula milk powder and preparation method of full dry-mixing infant formula milk powder |
| NL2020159B1 (en) * | 2017-12-22 | 2019-07-01 | Ausnutria Hyproca B V | Method for production of a dairy product and system for composing a dairy product |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391353C (en) * | 2006-01-06 | 2008-06-04 | 石家庄三鹿集团股份有限公司 | Formula milk powder for babies |
| CN101415461A (en) * | 2006-01-09 | 2009-04-22 | 儿童医院医疗中心 | Adiponectin for treatment of various disorders |
| MX2008010888A (en) * | 2006-02-28 | 2008-09-03 | Squibb Bristol Myers Co | Use of dha and ara in the preparation of a composition for preventing or treating obesity. |
| CN101233874B (en) * | 2008-02-02 | 2010-12-01 | 内蒙古蒙牛乳业（集团）股份有限公司 | Liquid state milk suitable for baby from 12 to 36 months old |
| CN101278688A (en) * | 2008-05-22 | 2008-10-08 | 澳大利亚迪唯恩乳业有限公司 | Infant nutrition immunity formula milk powder and method of preparing the same |
-
2010
- 2010-07-20 CN CN2010102307196A patent/CN101878819B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101878819A (en) | 2010-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Segura et al. | The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements? | |
| CN110754530A (en) | Formula milk powder capable of effectively promoting height development of children and production method thereof | |
| CN107668211B (en) | Infant formula goat milk powder for enhancing immune function and preparation method thereof | |
| CN101878819B (en) | Baby formula milk powder containing adiponectin and preparation method thereof | |
| CN102422907A (en) | Brain-strengthening intelligence-improving blend oil | |
| CN102224845B (en) | Follow-up infant formula | |
| Gould | Complementary feeding, micronutrients and developmental outcomes of children | |
| CN105558059A (en) | Formula goat milk powder for infants and preparation method thereof | |
| CN110214941A (en) | A kind of full nutrition special medicine purposes formula nutritional powder of adult and preparation method thereof | |
| CN105410918A (en) | Total nutrient formula powder and preparation method thereof | |
| Lawrence | Maternal nutrition and supplements for mother and infant | |
| CN105432792A (en) | Basic nutrition milk powder for preschool children, nutrition milk powder suit and preparation methods | |
| CN112042759A (en) | Nutritional formula powder for pregnancy and lactating mothers and preparation method thereof | |
| CN106615229A (en) | Grease suitable for pregnant women and lactating women to eat, as well as application thereof | |
| CN102090544B (en) | Selenium-rich goose feed and method for improving organic selenium in goose bodies | |
| Handayani et al. | Effect of Katuk Leaves (Sauropus androgynus (L.) Merr) on Breast Milk Production | |
| Atinmo et al. | Trace element content of breastmilk from mothers of preterm infants in Nigeria | |
| CN102405975B (en) | Liquid dairy product for improving child anorexia and preparation method thereof | |
| An et al. | Effects of supplementing calcium, iron and zinc on the fetus development and growth during pregnancy | |
| CN113678898A (en) | Milk powder beneficial to development and growth of children and preparation method thereof | |
| CN115104731B (en) | Nutritional composition and food comprising said nutritional composition | |
| CN112841310A (en) | Newborn formula liquid milk and preparation method thereof | |
| CN109892495A (en) | A kind of selenium-rich, the production method of zinc and iron chicken feed and selenium-rich, zinc and iron egg | |
| Nadimin et al. | Nutritional intervention based on moringa leaf flour to prevent stunting in first 1000 days of life (1000 HPK): Review articles | |
| CN109874744A (en) | A kind of production method of pregnant woman wet nurse's richness trace nutrient fresh hen egg |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |