CN101869103A - A kind of squalene plant acaricide and its application - Google Patents
A kind of squalene plant acaricide and its application Download PDFInfo
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- CN101869103A CN101869103A CN201010212508A CN201010212508A CN101869103A CN 101869103 A CN101869103 A CN 101869103A CN 201010212508 A CN201010212508 A CN 201010212508A CN 201010212508 A CN201010212508 A CN 201010212508A CN 101869103 A CN101869103 A CN 101869103A
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Abstract
本发明提供了一种以角鲨烯为主要原料，再加入溶剂、增溶剂和/或乳化剂制成的杀植物螨剂，是一种对人畜安全、环境友好型的和谐农药，对生态环境长远发展、人类的健康和病害的综合治理都具有深远的意义。本发明角鲨烯植物杀螨剂与传统的农药相比，具有以下的特点和优点：1、角鲨烯在自然界中大量存在，尤其是在植物、动物中含量较高，其毒性低，易降解，并对生态环境安全；2、角鲨烯提取方法较为简单，可通过超临界CO2萃取等工艺提取；3、角鲨烯也可通过人工合成，其成本低，易用于工业化大规模生产；4、角鲨烯由于其物理和化学特点，能溶于多种溶剂，易与其它杀螨成分混配制药，可起到提高杀螨效果的作用。The invention provides a plant acaricide made by taking squalene as the main raw material and adding solvent, solubilizer and/or emulsifier. It is a harmonious pesticide that is safe for humans and animals and friendly to the environment. The comprehensive management of long-term development, human health and diseases has far-reaching significance. Compared with traditional pesticides, the squalene plant acaricide of the present invention has the following characteristics and advantages: 1, squalene exists in a large number in nature, especially in plants and animals. 2. The extraction method of squalene is relatively simple, and can be extracted by supercritical CO2 extraction and other processes; 3. Squalene can also be artificially synthesized, and its cost is low, and it is easy to be used in large-scale industrialization Production; 4. Due to its physical and chemical characteristics, squalene can be dissolved in a variety of solvents, and it is easy to mix with other acaricidal ingredients to make pharmaceuticals, which can improve the acaricidal effect.
Description
Technical field
The present invention relates to the new purposes of a kind of squalene plant miticide and squalene.
Background technology
Squalene (Scopoletine) has another name called shark alkene, squalene, plain, the cod-liver oil terpene, 2,6,10,15,19 of dog-fish oil, 23-hexamethyl-2,6,10,14,18,22-tetracosa carbon six alkene; Molecular formula: C
30H
50Oily liquids; Little have a pleasant smell; To photaesthesia.Absorb oxygen and become stickiness such as flax oily; Be soluble in ether, dimethylbenzene, benzinum, acetone, carbon tetrachloride and other fat solvents, be slightly soluble in ethanol and glacial acetic acid, water-soluble hardly; Relative density 0.8584;-75 ℃ approximately of fusing points; 285 ℃ of boiling points; Index of refraction 1.4965; Viscosity (25 ℃) 12mPa/s; 200 ℃ of flash-points; Excitant is arranged.Squalene mainly is present in marine fishes and the vegetable fat, is widely used in fields such as medicine and cosmetics, has tumour cell, anti-cholesterol and the detoxication of inhibition, can improve human-body fatigue and release the pressure.There are some researches show that squalene can be as antibacterial agent, and have the effect of fiery ant of control and mosquito.But still there be not the application report of squalene in preparation plant resource miticide in the existing document; Still do not have at present a kind of good with environment compatibility, to the harmonious agricultural chemicals of mammalian safe.
Summary of the invention
The object of the invention is to disclose a kind of squalene plant miticide, and order of the present invention also is the new purposes of open squalene in the preparation plant acaricide.
The present invention seeks to be achieved through the following technical solutions:
The application of squalene in the preparation plant acaricide.
Squalene is added conventional auxiliary material, according to common process, make various forms of miticides: missible oil, suspending agent, pulvis or spray.
Wherein, auxiliary material is a solvent, can also add solubilizer and/or emulsifier.Solvent is benzinum, carbon tetrachloride, acetone, chloroform, benzene and/or dimethylbenzene, preferred dimethylbenzene; Solubilizer, emulsifier are spans, Tweens, glycol ester class, propylene glycol ester class and/or polyethylene glycol type non-ionic surface active agent.
Wherein, the raw material of missible oil consists of in the squalene miticide of the present invention:
Squalene 20-60 weight portion dimethylbenzene 30-70 weight portion emulsifier 5-15 weight portion.
The raw material of missible oil composition is preferably in the squalene miticide of the present invention:
Squalene 50 weight portion dimethylbenzene 40 weight portion emulsifier 10 weight portions.
The raw material of missible oil composition is preferably in the squalene miticide of the present invention:
Squalene 30 weight portion dimethylbenzene 60 weight portion emulsifier 10 weight portions.
The raw material of missible oil composition is preferably in the squalene miticide of the present invention:
Squalene 40 weight portion dimethylbenzene 50 weight portion emulsifier 10 weight portions.
Wherein, emulsifier is that the HLB value is 15 Tween-80.
The preparation method of missible oil is in the squalene miticide of the present invention: with the squalene xylene soluble, add emulsifier therein again, dissolving promptly can be used for mite extremely.
Wherein, described mite can be a Tetranychus cinnabarinus.
The invention provides a kind ofly, the comprehensive regulation of ecotope long term growth, human beings'health and disease is all had profound significance person poultry safety, environmentally friendly harmonious agricultural chemicals.Squalene plant miticide of the present invention is compared with traditional agricultural chemicals, and have following characteristics and advantage: 1, squalene exists in a large number at occurring in nature, and especially content is higher in plant, animal, and its toxicity is low, easily degraded, and to ecological environment security; 2, the squalene extracting method is comparatively simple, can pass through supercritical CO
2Technologies such as extraction are extracted; 3, squalene also can pass through synthetic, and its cost is low, is easy for large-scale industrialization production; 4, squalene can be dissolved in multiple solvent because its physics and chemical characteristic, easily kills the acaricidal composition pharmaceutical mixture with other, can play the effect of raising miticidal effect; 5, missible oil is solvent with dimethylbenzene in the squalene plant miticide of the present invention, can increase the solvability of squalene in water, and has the effect that promotes agricultural chemicals infiltration plant epidermis concurrently.
Compare with known plant resource acaricidal activity material, characteristics of the present invention are squalene except that having acaricidal activity, have the effect of bleeding agent and wetting agent concurrently.In addition, the acaricidal activity material of having reported at present mainly influences signal transduction system, causes Na
+, K
+, Ca
2+, Mg
2+ATPase is active to descend, and perhaps acts on acetylcholinergic receptor.Squalene does harm to the target spot difference of mite toxic action to agricultural: (1) external source is used squalene can suppress squalene synthetase and squalene cyclase activity in the Tetranychus cinnabarinus body, cause the cholesterol metabolic disorder, suppress the formation that evil mite cell membrane and hormone grade are produced thing.(2) external source is used squalene and can be activated the oxygenase activity, consumes NADPH in a large number, causes the disorder of lipid, fatty acid and nucleotide route of synthesis in the evil mite body.Therefore, squalene can carry out compositely with other acaricidal activity materials, reduces the chance that agricultural evil mite develops immunity to drugs.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Experimental example 1 squalene plant miticide of the present invention is to the inhibition experiment of Tetranychus cinnabarinus.
Prepare squalene plant acaricidal cream of the present invention according to the embodiment of the invention 1 described raw material and method, diluted concentration sees Table 1, carries out the inhibition experiment of Tetranychus cinnabarinus then.Experimental result sees Table 2 and table 3:
The table 1 concentration dilution multiple table of comparisons
Table 2 squalene missible oil is to the Tetranychus cinnabarinus effect (24 hours) of tagging
Table 3 squalene missible oil is to inhaling effect (24 hours) in the Tetranychus cinnabarinus
Experimental result shows that squalene plant miticide of the present invention has tag significantly effect and interior suction effect to Tetranychus cinnabarinus.
The screening experiment of experimental example 2 solvents of the present invention.
Dimethylbenzene, benzinum, acetone and 3 kinds of solvents of carbon tetrachloride are adopted in this experiment respectively, are that 32mg/mL tags and interior suction effect experiment according to table 1 preparation squalene content respectively.This experiment is intended to the optimum solvent of squalene is screened.Experiment adopts Tetranychus cinnabarinus to tag and systemic activity is measured, and the results are shown in Table 4 and table 5.The result shows that preferred solvent is a dimethylbenzene.
The squalene of table 4 different solvents is to the contact toxicity of the female one-tenth mite of Tetranychus cinnabarinus
Annotate: different lowercases represent to reach 5% horizontal significant difference in the same column.
The squalene of table 5 different solvents is to the systemic activity of the female one-tenth mite of Tetranychus cinnabarinus
Annotate: different lowercases represent to reach 5% horizontal significant difference in the same column.
Following embodiment all can realize the described effect of above-mentioned experimental example.
Embodiment
Embodiment 1: squalene plant acaricidal cream of the present invention
Squalene 50kg dimethylbenzene 40kg HLB value is 15 Tween-80 10kg.
With the squalene xylene soluble, add the HLB value therein again and be 15 Tween-80, add water-soluble separating again, can adopt spray pattern control Tetranychus cinnabarinus.
Embodiment 2: squalene plant acaricidal cream of the present invention
Squalene 30kg dimethylbenzene 60kg HLB value is 15 Tween-80 10kg.
With the squalene xylene soluble, add emulsifier therein again, dissolving can be adopted spray pattern control Tetranychus cinnabarinus.
Embodiment 3: squalene plant acaricidal cream of the present invention
Squalene 40kg dimethylbenzene 50kg HLB value is 15 Tween-80 10kg.
With the squalene xylene soluble, add emulsifier therein again, dissolving can be adopted spray pattern control Tetranychus cinnabarinus.
Embodiment 4: squalene plant of the present invention kills the mite suspending agent
Squalene added in the solvent acetone dissolve, add Arlacel-20 again, make squalene plant according to common process and kill the mite suspending agent, adopt the spraying mode to prevent and treat plant evil mite.
Embodiment 5: squalene plant of the present invention kills the mite pulvis
According to common process, add conventional auxiliary material, squalene is made pulvis, adopt the spraying mode to prevent and treat plant evil mite.
Embodiment 6: squalene plant of the present invention kills the mite spray
Squalene added in the solvent chloroform dissolve, add ethylene glycol again, make squalene plant according to common process and kill the mite spray, adopt the spraying mode to prevent and treat plant evil mite.
Claims (10)
1. squalene plant miticide is characterized in that this acaricidal raw material consists of:
Squalene 20-60 weight portion dimethylbenzene 30-70 weight portion emulsifier 5-15 weight portion.
2. miticide as claimed in claim 1 is characterized in that this acaricidal raw material consists of:
Squalene 50 weight portion dimethylbenzene 40 weight portion emulsifier 10 weight portions;
Or
Squalene 30 weight portion dimethylbenzene 60 weight portion emulsifier 10 weight portions;
Or
Squalene 40 weight portion dimethylbenzene 50 weight portion emulsifier 10 weight portions.
3. miticide as claimed in claim 1 or 2 is characterized in that wherein said emulsifier is that the HLB value is 15 Tween-80.
4. as the arbitrary described acaricidal preparation method of claim 1-3, it is characterized in that this method is:
With the squalene xylene soluble, add emulsifier therein again, dissolving promptly can be used for mite extremely.
5. prevent and treat application in the plant mites medicine as the arbitrary described miticide of claim 1-3 in preparation.
6. the application of squalene in the preparation plant acaricide.
7. as claim 5 or 6 described application, it is characterized in that wherein said plant mites is a Tetranychus cinnabarinus.
8. as claim 6 or 7 described application, it is characterized in that when the preparation plant acaricide, squalene being added conventional auxiliary material, according to common process, make various forms of miticides: missible oil, suspending agent, pulvis or spray.
9. application as claimed in claim 8 is characterized in that wherein said auxiliary material is a solvent: acetone, chloroform, benzene and/or dimethylbenzene.
10. application as claimed in claim 9 is characterized in that wherein said auxiliary material also adds solubilizer and/or emulsifier; Solvent is that solubilizer, emulsifier are spans, Tweens, glycol ester class, propylene glycol ester class and/or polyethylene glycol type non-ionic surface active agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010212508 CN101869103B (en) | 2010-06-22 | 2010-06-22 | Plant miticide of squalene and applications thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010212508 CN101869103B (en) | 2010-06-22 | 2010-06-22 | Plant miticide of squalene and applications thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101869103A true CN101869103A (en) | 2010-10-27 |
| CN101869103B CN101869103B (en) | 2013-07-10 |
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| CN 201010212508 Expired - Fee Related CN101869103B (en) | 2010-06-22 | 2010-06-22 | Plant miticide of squalene and applications thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101861860A (en) * | 2010-06-22 | 2010-10-20 | 北京农学院 | A kind of squalene plant fungicide and its application |
| CN102146014A (en) * | 2011-01-22 | 2011-08-10 | 李文东 | Method for extracting squalene by using camellia oleosa seeds as raw materials and tea oil and squalene soft capsules |
| CN103865689A (en) * | 2014-03-06 | 2014-06-18 | 张家界（中国）金驰大鲵生物科技有限公司 | Soap capable of inhibiting mites and preparation method thereof |
| JP2014133760A (en) * | 2009-02-10 | 2014-07-24 | Kochi Univ | Oviposition inhibitor for hemiptera pest, thysanoptera pest or acarina pest |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484599A (en) * | 1993-11-30 | 1996-01-16 | The President And Fellows Of Harvard College | Control of insect pests |
| JP2006008573A (en) * | 2004-06-25 | 2006-01-12 | Katayama Chem Works Co Ltd | Wood preservative and wood processing method using the same |
| US20080146444A1 (en) * | 2006-12-19 | 2008-06-19 | Polymer Ventures, Inc. | Method and compositions for improving plant growth |
| CN101861860A (en) * | 2010-06-22 | 2010-10-20 | 北京农学院 | A kind of squalene plant fungicide and its application |
-
2010
- 2010-06-22 CN CN 201010212508 patent/CN101869103B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484599A (en) * | 1993-11-30 | 1996-01-16 | The President And Fellows Of Harvard College | Control of insect pests |
| JP2006008573A (en) * | 2004-06-25 | 2006-01-12 | Katayama Chem Works Co Ltd | Wood preservative and wood processing method using the same |
| US20080146444A1 (en) * | 2006-12-19 | 2008-06-19 | Polymer Ventures, Inc. | Method and compositions for improving plant growth |
| CN101861860A (en) * | 2010-06-22 | 2010-10-20 | 北京农学院 | A kind of squalene plant fungicide and its application |
Non-Patent Citations (1)
| Title |
|---|
| EL-SAYED, N. H. ET AL.: "Flavonoids and other constituents from Bassia muricata and their insecticidal activities", 《REVISTA LATINOAMERICANA DE QUIMICA》, vol. 26, no. 3, 31 December 1998 (1998-12-31), pages 81 - 85, XP008003208 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014133760A (en) * | 2009-02-10 | 2014-07-24 | Kochi Univ | Oviposition inhibitor for hemiptera pest, thysanoptera pest or acarina pest |
| CN101861860A (en) * | 2010-06-22 | 2010-10-20 | 北京农学院 | A kind of squalene plant fungicide and its application |
| CN101861860B (en) * | 2010-06-22 | 2013-07-10 | 北京农学院 | Squalene plant fungicide and uses thereof |
| CN102146014A (en) * | 2011-01-22 | 2011-08-10 | 李文东 | Method for extracting squalene by using camellia oleosa seeds as raw materials and tea oil and squalene soft capsules |
| CN103865689A (en) * | 2014-03-06 | 2014-06-18 | 张家界（中国）金驰大鲵生物科技有限公司 | Soap capable of inhibiting mites and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101869103B (en) | 2013-07-10 |
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