CN101843637B - External spray for preventing and treating beriberi and preparation method - Google Patents
External spray for preventing and treating beriberi and preparation method Download PDFInfo
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- CN101843637B CN101843637B CN2010101736404A CN201010173640A CN101843637B CN 101843637 B CN101843637 B CN 101843637B CN 2010101736404 A CN2010101736404 A CN 2010101736404A CN 201010173640 A CN201010173640 A CN 201010173640A CN 101843637 B CN101843637 B CN 101843637B
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- 206010047601 Vitamin B1 deficiency Diseases 0.000 title claims abstract description 19
- 208000002894 beriberi Diseases 0.000 title claims abstract description 19
- 239000007921 spray Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 38
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 24
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 15
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000001263 FEMA 3042 Substances 0.000 claims abstract description 13
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims abstract description 13
- LRBQNJMCXXYXIU-QWKBTXIPSA-N gallotannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@H]2[C@@H]([C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-QWKBTXIPSA-N 0.000 claims abstract description 13
- 229940033123 tannic acid Drugs 0.000 claims abstract description 13
- 235000015523 tannic acid Nutrition 0.000 claims abstract description 13
- 229920002258 tannic acid Polymers 0.000 claims abstract description 13
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 claims abstract description 12
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000004327 boric acid Substances 0.000 claims abstract description 12
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 12
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 11
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 11
- 229940043350 citral Drugs 0.000 claims abstract description 9
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 229960004365 benzoic acid Drugs 0.000 claims abstract description 5
- 229960002645 boric acid Drugs 0.000 claims abstract description 5
- 239000012153 distilled water Substances 0.000 claims description 12
- 239000006166 lysate Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 9
- 235000010338 boric acid Nutrition 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 229960000583 acetic acid Drugs 0.000 abstract description 10
- 210000004243 sweat Anatomy 0.000 abstract 2
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- WXBLLCUINBKULX-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 WXBLLCUINBKULX-UHFFFAOYSA-N 0.000 description 8
- 208000008454 Hyperhidrosis Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 208000013460 sweaty Diseases 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000010171 animal model Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- VHBSECWYEFJRNV-UHFFFAOYSA-N 2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1O.OC(=O)C1=CC=CC=C1O VHBSECWYEFJRNV-UHFFFAOYSA-N 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 241000219784 Sophora Species 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- -1 plays sterilization Chemical compound 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides an external spray for preventing and treating beriberi and a preparation method. The external spray takes alcohol, acetic acid, salicylic acid, tannic acid, boric acid, citral and benzoic acid as raw materials, and is prepared by dilution, mutual solubility and filling. The external spray has efficacies of preventing and treating beriberi, foot sweat and foot odor. The statistical result of the clinical trial shows that the total effective rate of preventing and treating beriberi, foot sweat and foot odor is 95.34%, and the external spray can be used as a spray or be used for external smearing control.
Description
Technical field
The present invention relates to a kind of externally applied spray and preparation method of preventing and treating beriberi.
Background technology
Beriberi, sweaty foot, foot odor are the common skin diseases that is caused by fungal infection, according to statistics, the people of 70-80% suffers from beriberi, sweaty foot, foot odor disease in various degree among the adult, general summer the sickness rate height, winter, sickness rate was low, easily recurrence also has the people not heal throughout the year, and it is perplexing people's productive life.At present common have daktarin, a Compound Flavescent Sophora and Salicylic Acid Powder etc., although these medicines all have curative effect in various degree to beriberi, sweaty foot, foot odor patient, use not too convenient, prevention effect is not too obvious.
Summary of the invention
The purpose of this invention is to provide a kind of externally applied spray that can effectively prevent and treat beriberi, sweaty foot, foot odor, to overcome the defective that prior art exists.In conjunction with the human physilogical characteristic, antibiotic and sterilizing, it is stronger to prevent and treat performance.
Purpose of the present invention realizes by following measure, and a kind of externally applied spray of preventing and treating beriberi comprises the raw material of following ratio of quality and the number of copies:
Ethanol 66-80 acetic acid 1-2 salicylic acid 5-7 benzoic acid 4-6
Tannic acid 2-4 boric acid 1-3 citral 0-1 distilled water 8-12
Above-mentioned externally applied spray, can select to form by the raw material of following ratio of quality and the number of copies:
Ethanol 70 acetic acid 2 salicylic acid 6 benzoic acid 4
Tannic acid 4 boric acid 3 citrals 1 distilled water 10
A kind of preparation method of preventing and treating the externally applied spray of beriberi, adopt following processing step production:
A. dilute alcohol: in the ethanol of getting ready, add distilled water gradually, till to be mixed with concentration be 88% ethanol;
B. prepare lysate: the acetic acid of getting ready is poured into carried out misciblely in 88% ethanol, be mixed with lysate;
C. dissolve: salicylic acid, benzoic acid, boric acid, tannic acid, the citral got ready are poured in the lysate dissolved (shady and cool place), place 7-10 days each material at normal temperatures and all dissolve each other;
D. fill: utilize filling machine medicament to be poured in the spraying bottle of making in advance, bottleneck is closed seal, add outer package and be product.
The preventive and therapeutic effect of each composition:
Salicylic acid (salicylic acid) mainly plays the effect of removing the necrotic tissue meat; Benzoic acid (benzoic acid) mainly plays antifungal and deodorization; Boric acid mainly plays sterilization, sterilization and analgesic activity; Tannic acid (tannin) plays the convergence wound, promotes that wound heals as early as possible; Citral has the undue diaphoresis of skin, conditioning enhancing nervous system immunity and the neural effect of releiving of preventing; Acetic acid (glacial acetic acid) plays the maintenance medicament and stablizes, prevents sedimentary effect; Ethanol (medical alcohol) is mainly done solvent usefulness, and certain sterilization is arranged.Owing to add an amount of tannic acid, the convergence wound, the good results are evident for wound healing, and the comprehensive function of this medicine is removing the necrotic tissue degerming, anti-inflammatory analgesic, convergence wound, the nerve of releiving.
During use, can be sprayed on the skin affected part, therapeutic effect is obvious; Also can be sprayed on the socks, preventive effect is obvious.
The present invention shows that by following three cutaneous safeties test it belongs to safe external used medicine:
(1) exsomatize and to select for use rabbit as experimental animal, observe the toxic reaction that is produced for 3 times on the one after giving medication on the complete and damaged depilation skin of rabbit, after every rabbit intact skin and damaged skin were embrocated this medicinal liquid, toxigenicity reacted;
(2) exsomatize and to select for use Cavia porcellus, after making guinea pig skin repeat to contact this medicinal liquid, observe body immune system and be reflected at performance on the skin, do not cause tangible skin hypersensitivity reaction as experimental animal;
(3) exsomatize and to select for use rabbit as experimental animal, observe rabbit intact skin and damaged skin and embrocate the irritant reaction that is produced behind this medicinal liquid, skin does not produce irritative response.
Through clinical statistics, beriberi, sweaty foot, foot odor patient clinical experiment situation:
From in July, 2009--in January, 2010, we utilize the time of half a year, and by 300 routine patients (male 196 examples, women 104 examples, age 9-80 year) the prevention effect analysis to clinical prevention, cure rate accounts for 68%; Improvement rate accounts for 27.34%; Inefficiency only accounts for 4.67%; Total effective rate reaches 95.34%.(efficacy assessment standard and the results are shown in Table 1, table 2):
Table 1 efficacy assessment standard
Table 2 clinical curative effect analysis
Show through above-mentioned animal pharmacodynamic experiment and patient's clinical statistics note result: the present invention is a kind of externally applied spray that can effectively prevent and treat beriberi, sweaty foot, foot odor really.
The specific embodiment
Embodiment 1: a kind of externally applied spray and preparation method of preventing and treating beriberi comprises the raw material of following ratio of quality and the number of copies:
Ethanol 70 acetic acid 2 salicylic acid 6 benzoic acid 4
Tannic acid 4 boric acid 3 citrals 1 distilled water 10
Adopt following processing step production:
A. dilute alcohol: adding distilled water in the ethanol of getting ready gradually, is 88% ethanol until being mixed with concentration, remains a little distilled water and outwells;
B. prepare lysate: the acetic acid of getting ready is poured into carried out misciblely in 88% ethanol, be mixed with lysate;
C. dissolve: salicylic acid, benzoic acid, boric acid, tannic acid, the citral got ready are poured in the lysate dissolved (shady and cool place), place 9 days each materials at normal temperatures and all dissolve each other;
D. fill: utilize filling machine medicament to be poured in the spraying bottle of making in advance and (quantitatively be 25 milliliters), bottleneck is closed seal, add outer package and be product.
Embodiment 2: a kind of externally applied spray and preparation method of preventing and treating beriberi comprises the raw material of following ratio of quality and the number of copies:
Ethanol 80 acetic acid 1.5 salicylic acid 5 benzoic acid 6
Tannic acid 2 boric acid 1 citral 0.2 distilled water 11
Adopt following processing step production:
A. dilute alcohol: adding distilled water in the ethanol of getting ready gradually, is 88% ethanol until being mixed with concentration, remains a little distilled water and outwells;
B. prepare lysate: the acetic acid of getting ready is poured into carried out misciblely in 88% ethanol, be mixed with lysate;
C. dissolve: salicylic acid, benzoic acid, boric acid, tannic acid, the citral got ready are poured in the lysate dissolved (shady and cool place), place 7 days each materials at normal temperatures and all dissolve each other;
D. fill: utilize filling machine medicament to be poured in the spraying bottle of making in advance and (quantitatively be 25 milliliters), bottleneck is closed seal, add outer package and be product.
Claims (3)
1. externally applied spray of preventing and treating beriberi is characterized in that being made up of the raw material of following ratio of quality and the number of copies:
Ethanol 66-80 acetic acid 1-2 salicylic acid 5-7 benzoic acid 4-6
Tannic acid 2-4 boric acid 1-3 0＜citral≤1 distilled water 8-12.
2. a kind of externally applied spray of preventing and treating beriberi according to claim 1, its feature is made up of the raw material of following ratio of quality and the number of copies:
Ethanol 70 acetic acid 2 salicylic acid 6 benzoic acid 4
Tannic acid 4 boric acid 3 citrals 1 distilled water 10.
3. preparation method of preventing and treating the externally applied spray of beriberi is characterized in that comprising following production stage:
A. dilute alcohol: in the ethanol of getting ready, add distilled water gradually, be mixed with concentration and be till 88% the ethanol;
B. prepare lysate: the acetic acid of getting ready is poured into carried out misciblely in 88% ethanol, be mixed with lysate;
C. dissolve: salicylic acid, benzoic acid, boric acid, tannic acid, the citral got ready are poured in the lysate dissolved, place 7-10 days each material at normal temperatures and all dissolve each other;
D. fill: utilize filling machine that medicament is poured in the quantitative spraying bottle, bottleneck is closed seal, add outer package and be product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101736404A CN101843637B (en) | 2010-05-17 | 2010-05-17 | External spray for preventing and treating beriberi and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101736404A CN101843637B (en) | 2010-05-17 | 2010-05-17 | External spray for preventing and treating beriberi and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101843637A CN101843637A (en) | 2010-09-29 |
| CN101843637B true CN101843637B (en) | 2011-12-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2010101736404A Active CN101843637B (en) | 2010-05-17 | 2010-05-17 | External spray for preventing and treating beriberi and preparation method |
Country Status (1)
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| CN (1) | CN101843637B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972270B (en) * | 2010-11-09 | 2012-07-25 | 石家庄乐足科技有限公司 | External powder for preventing and curing dermatophytosis |
| CN104258005A (en) * | 2014-09-10 | 2015-01-07 | 欧阳铭浩 | Botanical spray for treating beriberi |
| CN104258004A (en) * | 2014-09-10 | 2015-01-07 | 欧阳铭浩 | Preparation method of botanical spray for treating beriberi |
| CN104258003A (en) * | 2014-09-10 | 2015-01-07 | 欧阳铭浩 | Preparation method of spray for treating beriberi |
| CN104274670A (en) * | 2014-09-10 | 2015-01-14 | 欧阳铭浩 | Spray for treating beriberi |
| CN105832765A (en) * | 2016-05-12 | 2016-08-10 | 段泽恺 | External liquid medicine for preventing and treating beriberi and preparation method thereof |
| CN110859851A (en) * | 2019-11-29 | 2020-03-06 | 王江涛 | Antifungal spray and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559438A (en) * | 2004-03-02 | 2005-01-05 | 赵传宝 | Medicine for treating tinea pedis, and prepn. method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101172150A (en) * | 2006-10-31 | 2008-05-07 | 张茂林 | Externally used medicament for treating beriberi |
| CN101342190A (en) * | 2008-07-26 | 2009-01-14 | 王富才 | Medicament composition for treating beriberi |
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2010
- 2010-05-17 CN CN2010101736404A patent/CN101843637B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559438A (en) * | 2004-03-02 | 2005-01-05 | 赵传宝 | Medicine for treating tinea pedis, and prepn. method |
Non-Patent Citations (3)
| Title |
|---|
| 刘玉明等.怀氏酊配方的改进与疗效观察.《大连医学院学报》.1994,第16卷(第1期),第72页. * |
| 安秀梅.脚气药水的制备及临床应用.《基层医学论坛》.2007,第11卷(第1期),第12页. * |
| 麦国荣.脚癣药水配制方法的改进.《中国医院药学杂志》.1985,第5卷(第4期),第39页左栏倒数第14行－倒数第4行配方（1）. * |
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| CN101843637A (en) | 2010-09-29 |
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Inventor after: Duan Huaisuo Inventor after: Wang Boyun Inventor after: Qi Shengwei Inventor after: He Jianguo Inventor after: Liu Jingxin Inventor after: Ma Zichuan Inventor after: Yan Xingpo Inventor after: Duan Jie Inventor after: Gu Fengying Inventor before: Duan Huaisuo Inventor before: Wang Boyun Inventor before: He Jianguo Inventor before: Liu Jingxin Inventor before: Ma Zichuan Inventor before: Yan Xingpo Inventor before: Duan Jie Inventor before: Gu Fengying |
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