CN101972270B - External powder for preventing and curing dermatophytosis - Google Patents

Abstract

The invention provides an external powder for preventing and treating beriberi, which is prepared from zinc acetate, benzoic acid, salicylic acid, zinc sulfate and the like as raw materials. The agent has the effect of preventing and treating athlete's foot, foot sweat, and foot odor. According to the statistical results of clinical trials, the total effective rate is 96.87%. It can be used as a foot bath or footwear soaking to prevent and treat athlete's foot.

Description

A kind of external powder for preventing and treating beriberi

technical field

The invention relates to an external powder for preventing and treating beriberi.

Background technique

With the continuous improvement of people's living standards, it has become a fashion to pursue a high-grade lifestyle. Athlete's foot, foot sweat, and foot odor are common skin diseases caused by fungal infections. Generally, the incidence is high in summer and low in winter. , easy to relapse, and some people do not heal all the year round. It plagues people's production and life. At present, common medicines for the treatment of this chronic disease include foot light powder, foot light powder, etc. Although these medicines have different degrees of curative effect on patients with beriberi, foot sweat, and foot odor, the prevention and treatment effect is not obvious.

Contents of the invention

The purpose of the present invention is to provide a kind of powder for external use that can effectively prevent and treat athlete's foot, foot sweat and foot odor, so as to overcome the defects in the prior art.

The object of the present invention is achieved by the following measures, a kind of powder for external use of prevention and treatment of beriberi, comprising the raw materials of following mass and fraction ratio:

Zinc acetate 12-15 Benzoic acid 10-13 Salicylic acid 9-12 Zinc sulfate 5-8

The above-mentioned powder for external use can be selected to be composed of the following raw materials in the ratio of parts by mass:

Zinc acetate 15 Benzoic acid 13 Salicylic acid 9 Zinc sulfate 8

The external powder for preventing and treating beriberi is produced through the following process steps:

a. Ingredients: Weigh the raw materials according to the above mass/part ratio, put them into the prepared acid-resistant container and stir them, try to make them evenly mixed.

b. Pulverization: Pour the uniformly mixed material into a pulverizer for pulverization. The temperature during pulverization is 10-110°C, and the size of pulverization is controlled at about 100 mesh.

c. Stirring gong: Stir the crushed material evenly, and then carry out gong treatment to become the semi-finished material. the

d. Filling: use the filling machine to put the semi-finished material into the quantitative small bag or vial, seal the mouth well, and add the outer packaging to get the product.

Zinc acetate [(CH3COO)2Zn.2H2O] dissolves in water to form an excellent solvent to promote the dissolution of benzoic acid and salicylic acid in water; zinc sulfate (ZnSO4.7H2O) has the effect of astringent sweat glands; Benzoic acid (benzoic acid) mainly plays the role of inhibiting fungal growth and repelling odor; salicylic acid (salicylic acid) mainly plays the role of removing carrion. Due to the addition of zinc acetate, the solubility is improved, and organic acids such as benzoic acid and salicylic acid are dissolved in water as soon as possible, and the effectiveness of the composition is greatly improved, and the effects of antibacterial, sterilizing, deodorizing and sweat removal are more obvious.

When in use, take 5 small bags of the product of the present invention, pour it into a container filled with 2500 milliliters of warm water and dissolve it, and then make this solution, soak the foot with this solution for 10-15 minutes, and can prevent and treat athlete's foot, foot sweat, and foot odor; Or take 1 sachet of the product of the present invention, pour it into a container filled with 500 milliliters of warm water and dissolve it, and soak the footwear for 1-2 minutes with the solution to remove the peculiar smell of the footwear.

The present invention (the product name of the present invention is " full platinum ") shows that it belongs to safe externally used medicine by following three skin safety tests:

Tested product: get " pure platinum " powder (specification 5 grams/bag, batch number 20090615, plastic bag packaging) one pouch, pour into the container that fills 500 milliliters of distilled water and dissolve, be mixed with " pure platinum " solution. Usage and dosage: Dip the solution on cotton wool and rub the injured area (in the following three safety tests, we refer to the "Zu Platinum" solution as "medicine solution").

Toxicity test: In this test, rabbits were selected as experimental animals to observe the toxic reaction after administering the drug solution on intact and damaged depilated skin of rabbits three times a day. Take 8 healthy rabbits. 24 hours before the test, the hair on both sides of the back of each rabbit was firstly removed with a curved cut of about 150 cm ² , and then the hair was removed with 8% sodium sulfide solution. They were randomly divided into two groups (4 rats in each group), that is, the intact skin group and the damaged skin group. After 24 hours of depilation, the body weight of the rabbit was weighed and recorded (initial body weight). Fix the rabbits in the fixed frame. The rabbits in the intact skin group apply 6ml of the drug solution on the depilated epidermis, and fix it with non-irritating gauze and adhesive tape; the depilated epidermis of the damaged skin group are first sterilized with 75% ethanol. Then use a sterile needle to make network-like scratches until the blood oozes. Immediately apply 6ml/piece of the drug solution on the scratched and oozing epidermis, and fix it with non-irritating gauze and adhesive tape. After administration, the rabbits in the two groups were sent back to their respective cages, and free access to food and water resumed. Apply once every 4 hours and apply 3 times in a row. After 24 hours, wash off the liquid medicine with warm water for observation. Observe and record the skin, hair, eyes, mucous membrane, body weight of rabbits at 1, 24, 48, 72 hours and 4, 5, 6, 7 days after administration, as well as changes in respiration, circulation, central nervous system, limb activities, etc. . The rabbits in the intact skin group and the damaged skin group were treated with medicine three times a day, and observed continuously for 7 days. The damaged skin healed itself after 24 hours; no skin erythema, edema, hair, eyes, mucous membranes and breathing were found in the depilated skin of the two groups of rabbits. , circulation, central nervous system, and extremities were normal. The results showed that no toxic reaction occurred after the "Zu Platinum" liquid was applied to the intact skin and damaged skin of each rabbit (see attached table: acute toxicity test records).

Allergy test: Guinea pigs were selected as experimental animals in vitro, and the performance of the body's immune system on the skin was observed after the skin of the guinea pigs was repeatedly exposed to the liquid medicine. Select 30 white guinea pigs, weighing 250-300 g, half male and half male, and 24 hours before the administration, the hair on both sides of the back of the guinea pigs is removed, and the depilatory area is about 3×3cm ² on each side. Choose 2,4-dinitrochlorobenzene to make 1% sensitization solution with acetone and 0.1% excitation concentration as the positive sensitizer. The guinea pigs were randomly divided into 3 groups according to body weight and sex, 10 in each group (half male and half male). The first group was given the test drug solution; the second group was blank control (solvent: 50% ethanol); the third group was positive control (positive sensitizer).

For sensitization contact, take 0.2ml of the drug solution and apply it to the depilated area on the left side of the guinea pig, fix it with non-irritating gauze and adhesive tape, and continue for 6 hours, then wash off the drug solution with warm water. On the 7th and 14th day, repeat in the same way. The method of blank control group and positive control group is the same as above.

For stimulating contact, 14 days after the sensitization of the last drug solution, apply 0.2ml of the drug solution to the depilated area on the right side of the back of the guinea pig, and fix it with gauze and adhesive tape. After 6 hours, wash off the drug solution with warm water, observe immediately, and then Observe the skin allergic reaction again at 24, 48, and 72 hours, and score according to Table 1 (Appendix 1-Scoring Standards for Skin Allergic Reaction). The blank control group and the positive substance control method are the same as the test drug group.

After 3 sensitization exposures, mild erythema was seen in the positive control group, which subsided after 3 days; no erythema was seen in the drug treatment group and blank control group; after stimulation exposure, edematous erythema was seen in the positive control group, which was still visible after 72 hours ; There was no erythema and edema in the administration group and the blank control group. After the test results were scored according to the skin reaction scoring standard, according to the difference in the skin reaction of the guinea pigs between the test group and the control group, the nature of the allergic reaction of the medicinal solution to the skin was judged according to Table 1 (see Attached Table 3--Evaluation of the allergic reaction to the medicinal solution of "Foot Platinum") ). The sensitization rate is judged according to the classification in Attached Table 2 (see Attached Table 2--Evaluation of Skin Irritation Intensity). The sensitization rate is calculated by dividing the number of animals with skin erythema or edema (regardless of severity) by the total number of animals tested. The results showed that: "Zubaijin" liquid did not cause obvious skin allergic reaction.

Irritation test: In this test, rabbits are selected as experimental animals, and the irritation reaction produced after rubbing the liquid medicine on the intact skin and damaged skin of the rabbits is observed. Take 6 healthy rabbits, 24 hours before the test, first remove the hair on both sides of the back of each rabbit with a curved shear about 150cm ² , and then use 8% sodium sulfide solution to remove the hair, and divide them into 2 groups randomly (3 rabbits in each group), namely In the intact skin group and the damaged skin group, after 24 hours of depilation, the body weight of the rabbits was weighed and recorded. Before administration, the rabbits were fixed in a fixed frame. In the intact skin group, 1ml of the drug solution was applied to the left depilated epidermis, and dried naturally; the right depilated area was smeared with 0.9% sodium chloride solution as a blank control. The epidermis of rabbits in the damaged skin group was first sterilized with 75% ethanol, and then scratched in a network shape with a sterile needle until the blood oozes. Dry; the right side scratches and oozes the depilated epidermis and rubs 0.9% sodium chloride solution as a blank control. After fixing with non-irritating gauze and adhesive tape, the rabbits were sent back to their respective cages, and free eating and drinking resumed. After 24 hours, wash off the residual test drug with warm water for observation. Observe and record the rabbit skin erythema, edema and other phenomena as well as the recovery situation and time of these changes 1, 24, 48, 72 hours after removing the test substance. It was found that the rabbits in the intact skin group and the damaged skin group had no skin erythema and edema after taking medicine once a day, and the damaged skin healed itself after 24 hours. The test results of each rabbit were scored according to the skin irritation reaction, erythema and The edema score was all 0; the skin irritation intensity score was <0.5. Show that the medicinal solution is non-irritating to the skin (see Irritation Test Schedule 1, Schedule 2).

The statistical results of clinical patient trials show that the prevention and treatment effect of the drug is indeed very good:

The test drug—a powder for external use that can effectively prevent and treat beriberi, foot sweat, and foot odor is clinically used as "Zu Platinum", specification: 5 g/bag, batch number: 20091015, packed in plastic bags.

From November 2009 to May 2010, we used half a year to analyze the prevention and treatment effects of 480 clinical patients (323 males and 157 females, aged 10-76 years), 332 cases were cured and 133 cases improved ; Only 15 cases were invalid; the total effective rate was 96.87%. (See Table 1 and Table 2 for efficacy evaluation criteria and results):

The results of the above three skin safety tests and clinical patient statistics show that the present invention is indeed a powder for external use that can effectively prevent and treat beriberi, foot sweat and foot odor.

Detailed ways

Embodiment 1: a kind of powder for external use of prevention and treatment of beriberi and preparation method, comprise the raw material of following mass fraction ratio:

Zinc Acetate 15 Benzoic Acid 13 Salicylic Acid 10 Zinc Sulfate 5

Produced using the following process steps:

a. Ingredients: Weigh the raw materials according to the above mass/part ratio, put them into the prepared acid-resistant container and stir them, try to make them evenly mixed.

b. Pulverization: Pour the uniformly mixed material into a pulverizer for pulverization, the temperature during pulverization is 100°C, and the size of pulverization is controlled at 100 mesh.

c. Stirring gong: Stir the crushed material evenly, and then carry out gong treatment to become the semi-finished material. the

d. Filling: use the filling machine to put the semi-finished material into the quantitative vial, seal the mouth, and add the outer packaging to get the product.

Embodiment 2: a kind of powder for external use of prevention and treatment of beriberi and preparation method, comprise the raw material of following mass fraction ratio:

Zinc acetate12 Benzoic acid10 Salicylic acid12 Zinc sulfate8

Produced using the following process steps:

a. Ingredients: Weigh the raw materials according to the above mass/part ratio, put them into the prepared acid-resistant container and stir them, try to make them evenly mixed.

b. Pulverization: Pour the uniformly mixed material into a pulverizer for pulverization. The temperature during pulverization should not exceed 80°C, and the size of pulverization should be controlled at 90 mesh.

c. Stirring gong: Stir the crushed material evenly, and then carry out gong treatment to become the semi-finished material. the

d. Filling: Use the filling machine to put the semi-finished material into the quantitative small bag, seal the mouth, and add the outer packaging to get the product.

Claims (2)

1. an external powder for preventing and treating beriberi is characterized in that it is made up of the raw materials of following mass and fraction ratio: Zinc acetate 12-15 Benzoic acid 10-13 Salicylic acid 9-12 Zinc sulfate 5-8 Weigh the raw materials according to the above mass-to-part ratio, put them into the prepared acid-resistant container and mix them, after crushing, stirring, gongs, and filling, it is the product. 2. the powder for external use of a kind of prevention and treatment of beriberi according to claim 1, is characterized in that being made up of the raw material of following mass fraction ratio: Zinc acetate15 Benzoic acid13 Salicylic acid9 Zinc sulfate8.