CN101816769B - Medicament for treating cardiac, cerebral and vascular diseases - Google Patents
Medicament for treating cardiac, cerebral and vascular diseases Download PDFInfo
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Abstract
The invention relates to a medicament for treating cardiac, cerebral and vascular diseases. A preparation method comprises the following steps of: uniformly mixing 160 to 200 parts of sanguisuga, 100 to 150 parts of dragon's blood, 120 to 160 parts of radix pseudo-ginseng, 1 to 2 parts of artificial musk, 100 to 150 parts of sandalwood, 80 to 120 parts of frankincense, 80 to 120 parts of myrrh, 100 to 150 parts of Chinese angelica, 100 to 150 parts of szechuan lovage rhizome, 120 to 160 parts of root of red-rooted salvia and 100 to 150 parts of radix curcumae, grinding the mixture into fine powder capable of passing a sieve of 80 to 100 meshes, sterilizing, and encapsulating to prepare the medicament. The medicament has the effects of nourishing Qi and activating blood, removing stasis and reducing turbidity, warming Yang and transfering Qi, moving Qi and dissipating binds, and refreshing brain and opening orifices, and mainly treats coronary heart disease, myocardial infarction, angina, hyperlipemia, high blood viscosity syndrome, cerebral thrombosis, cerebral infarction, and hemiplegia, facial paralysis, language disadvantage, limb numbness, weakness, ballism, encephalatrophy, senile dementia caused by cerebral hemorrhage sequela and other symptoms; Clinical application of 2,580 cases of patients with cardiac, cerebral and vascular diseases proves that the cure rate of the medicament is 78 percent; and the total effective rate of the medicament is 98.8 percent.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, particularly relating to a kind of is the medicine of the treatment cardiovascular and cerebrovascular disease of crude drug preparation with Chinese medicine.
Background technology
Modern's rhythm of life is accelerated, operating pressure increases, and it is irregular to live, and causes that the sickness rate of cardiovascular and cerebrovascular disease increases day by day, and is tending towards rejuvenation.Cardiovascular and cerebrovascular disease (traditional Chinese medical science is referred to as the apoplexy and the thoracic obstruction) comprises hypertension, hyperlipidemia, coronary heart disease, arteriosclerosis, cardiomyopathy, angina pectoris, premature beat, arrhythmia, atrial fibrillation, myocardial infarction, cerebral vasospasm, cerebral infarction, cerebral hemorrhage etc., it is a big persistent ailment that threatens human health, characteristics are that morbidity is dangerous, disability rate is high, case fatality rate is high, the first place that present sickness rate has occupied various diseases.
Modern medicine enriches for rescue and treatment level advanced person, the means of cardiovascular and cerebrovascular disease, but be not very good then seeming aspect the prevention of disease and the convalescent care, particularly the treatment for the disease sequela just lacks effective method and means especially.And the big potentiality of tool that Chinese medicine exactly has the incomparable superiority of western medicine in these areas and remains further to be excavated development.
The Chinese medicine cardiovascular and cerebrovascular disease is with a long history, because determined curative effect, toxic and side effects are little, at aspects such as prevention, treatment, rehabilitations clear superiority is arranged.Domestic medical worker makes great efforts to excavate motherland's pools of traditional Chinese medicine, succeeded in developing in succession as Chinese patent medicines such as FUFANG DANSHEN PIAN, SHANHAI PILL, XUESHUANXINMAINING, restorative bolus, ZHONGFENG HUICHUN WAN, XINNAOSHUTONG JIAONANG, Herba Erigerontis tablet, collateral dredging blood circulation promoting slice, NAOXUESHUAN PIAN, QINGKAILING, made the treatment of cardiovascular and cerebrovascular disease and prevention that new development arranged.Simultaneously, also have a lot, respectively have one's own knack, but also deficiency is arranged respectively about the patent application for the treatment of cardiovascular and cerebrovascular disease Chinese medicine.
Summary of the invention
The purpose of this invention is to provide a kind ofly have QI invigorating concurrently, invigorate blood circulation, the collateral dredging effect, the Chinese medicine medicine of outstanding effect treatment cardiovascular and cerebrovascular disease.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Hirudo 160～200 Sanguis Draxonis 100～150 Radix Notoginseng 120～160
Artificial Moschus 1～2 Lignum Santali Albi 100～150 Olibanums 80～120
Myrrha 80～120 Radix Angelicae Sinensis 100～150 Rhizoma Chuanxiongs 100～150
Radix Salviae Miltiorrhizae 120～160 Radix Curcumaes 100～150.
Said medicine can be made any peroral dosage form on the pharmaceutics, as tablet, pill, watered pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each component being made medicine capsule of the present invention is:
The above-mentioned raw materials medicine according to described parts by weight mix homogeneously, is ground into the fine powder by 80～100 mesh sieves, and sterilization is made in incapsulating.
Every of the capsule of more than making contains crude drug 1 gram, takes 3～4 at every turn, and is every day 3 times, oral.
Cardiovascular and cerebrovascular disease belongs to Chinese medicine " thoracic obstruction ", " pained " reaches " apoplexy " category, and see the earliest " interior ask the numbness opinion through element ": heart person arteries and veins is obstructed, tired then severe palpitation.Its etiology and pathogenesis is many by visceral dysfunction, or QI and blood deficiency, and to be worried angry in addition, and it is immoderate to indulge in excessive drinking, the surfeit delicious food, the overstrain internal injury, imbalance of YIN and YANG, so that essential resistance of turbid phlegm, qi depression to blood stasis, liver-wind stirring up internally, visceral dysfunction, QI-blood circulation is not smooth, and the stasis of blood hinders heart and brain and goes and wait into the danger of obturation.Chinese medicine is thought, " qi being the governor of blood ", and " the capable then blood of gas is capable ", " stagnation of QI is blood stasis then ", and blood stasis is the not normal pathological product of blood flow operation.
In the prescription of the present invention, Hirudo is longer than removing blood stasis by becoming silted up, and the diuretic antiinflammatory of stimulating the menstrual flow, and contain foreign preteins has anticoagulation, and blood fat reducing, to fall blood sticking, and the haemolysis embolism extinguishing promotes the effect of blood circulation, is main apoplexy, the good medicine of treatment heart and brain blood disorders disease; 5 with the pseudo-ginseng blood-circulation-invigovating blood stasis dispelling, subduing swelling and relieving pain, and auxilliary replenishing QI and blood, the enhancing body resistivity, to coronary heart disease, hypercholesterolemia disorders of blood and hyperlipemia disease all have curative effect preferably; Sanguis Draxonis restores menstrual flow and invigorates blood circulation, and eliminating stasis to stop pain is equipped with stasis in the Olibanum circulation of qi promoting, the stagnation of QI in the Myrrha promoting the circulation of blood, and blood circulation promoting and blood stasis dispelling, promoting blood circulation, in addition Lignum Santali Albi, Radix Curcumae the chest stuffiness relieving are regulated the flow of vital energy again, resolving depressionization stagnates, and Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis nourishing blood and promoting blood circulation are regulated the heart and brain blood flow; Artificial Moschus's awakening consciousness, promoting flow of QI and blood, blood stasis dispelling refreshment; Rhizoma Chuanxiong is a gas medicine in the blood, blood-activating and qi-promoting, and inducing menstruation to relieve menalgia, medicine carrying ends row, through sick institute; More than all medicines complement each other altogether, merit is not just being hindered, and does not capablely stay silt, to separate the danger of heart and brain stagnation of QI-blood, opens the hinge of blood circulation obturation.
Pharmic function benefiting QI for activating blood circulation of the present invention; the blood stasis dispelling the turbid descending; the warming YANG activating QI; promoting QI to circulate and dispersing the agglomeration of the pathogens, consciousness-restoring and orifice-opening, promoting blood circulation; the haemolysis embolism extinguishing; vessel softening, anticoagulation, blood fat reducing; reduce blood viscosity; promote the heart and brain blood circulation, blood flow increasing is opened stasis; blood is sticking; the heart and brain infraction that thrombosis causes; attack to mend and have both; two-ways regulation; protection heart and brain tissues hypoxic-ischemic promotes the cerebral nerve restore funcitons, cures mainly coronary heart disease; myocardial infarction; angina pectoris; hyperlipidemia; high blood viscosity disease; cerebral thrombosis; hemiplegia due to cerebral infarction and the apoplexy sequela; facial hemiparalysis; dysphonia; numb limbs and tense tendons; the weak and limp contraction of jerking; disease such as brain atrophy and senile dementia.
For further investigating the clinical efficacy and the safety of medicine of the present invention, select 2580 routine cardiovascular and cerebrovascular disease cases that the curative effect of medicine of the present invention is carried out clinical observation.
2580 routine MethodsThe cases enrolled all meet cardiovascular and cerebrovascular vessel diagnostic criteria also, make a definite diagnosis through the CT of hospital above county level, nuclear magnetic resonance, NMR, rheoencephalogram, electrocardiogram and various laboratory examination.
Cerebrovascular disease 1134 examples, cerebral thrombosis 456 examples wherein, cerebral infarction 381 examples, apoplexy sequela 294 examples, brain atrophy 13 examples.Male's 628 examples, women's 516 examples, maximum 71 years old age, minimal ages 40 years old.40～50 years old 268 examples, 51～60 years old 529 example, 61～71 years old 337 example.
Cardiovascular pathological changes 1446 examples, coronary atherosclerotic heart disease 636 examples wherein, myocardial infarction 389 examples, angina pectoris 421 examples.Male's 832 examples, women's 614 examples.The oldest 70 years old, minimum 38 years old.38～48 years old 232 examples, 49～59 years old 571 example, 60～70 years old 643 example.
Above case all gives medicine capsule of the present invention, every day 3 times, each 3～4, oral meal.Three months is a course of treatment, takes 2～3 courses of treatment continuously.
Curative effect determinate standard: according to country " clinical diagnosis is according to curing the improvement standard ".
Cure: after treating 2～3 courses of treatment, the positive sign of symptom and objective determination disappears, and has recovered normal work and viability, observes continuously and does not have recurrence more than 3 years.
Take a turn for the better: through treating 2～3 courses of treatment, positive Signs of symptom and objective determination and cardinal symptom disappear, and have recovered certain work and self care ability, observe continuously and do not have recurrence more than 2 years.
Invalid: through treat 2 the course of treatment symptom and sign do not have obvious improvement.
Observe therapeutic effect according to criterion of therapeutical effect, see attached list 1,2.
Table 1 treatment cerebrovascular disease 1134 routine curative effect statistics
Table 2 treatment cardiovascular pathological changes 1446 routine curative effect statistics
From 1998 so far, go through and 2580 routine cardiovascular and cerebrovascular vessel patient's clinical practices medicine capsule of the present invention treated in 12 years, and long term follow-up checking efficacy result, cure rate 78% obtained, the significant curative effect of total effective rate 98.8%.
The specific embodiment
Embodiment 1
Medicine is chosen most impurity, screening dry in the sun, after the oven dry, water intaking trematodiasis 360 gram, Sanguis Draxonis 240 grams, Radix Notoginseng 300 grams, artificial Moschus's 4 grams, Lignum Santali Albi 240 grams, Olibanum 180 grams, Myrrha 180 grams, Radix Angelicae Sinensis 240 grams, Rhizoma Chuanxiong 240 grams, Radix Salviae Miltiorrhizae 300 grams, Radix Curcumae 240 grams are evenly mixed, be ground into fine powder, extremely all by 100 mesh sieves, constant temperature drying was sterilized 1 hour, the Capsules of packing under the sterile working No. 0, every contains crude drug 1 gram, makes 2500 of capsules.
Hirudo 160～200 Sanguis Draxonis 100～150 Radix Notoginseng 120～160
Artificial Moschus 1～2 Lignum Santali Albi 100～150 Olibanums 80～120
Myrrha 80～120 Radix Angelicae Sinensis 100～150 Rhizoma Chuanxiongs 100～150
Radix Salviae Miltiorrhizae 120～160 Radix Curcumaes 100～150.
Embodiment 2
Medicine is chosen most impurity, screening dry in the sun, after the oven dry, water intaking trematodiasis 400 gram, Sanguis Draxonis 200 grams, Radix Notoginseng 300 grams, artificial Moschus's 4 grams, Lignum Santali Albi 200 grams, Olibanum 200 grams, Myrrha 200 grams, Radix Angelicae Sinensis 300 grams, Rhizoma Chuanxiong 200 grams, Radix Salviae Miltiorrhizae 240 grams, Radix Curcumae 300 grams are evenly mixed, be ground into fine powder, extremely all by 100 mesh sieves, constant temperature drying was sterilized 1 hour, the Capsules of packing under the sterile working No. 0, every contains crude drug 1 gram, makes 2500 of capsules.
Embodiment 3
Medicine is chosen most impurity, screening dry in the sun, after the oven dry, water intaking trematodiasis 320 gram, Sanguis Draxonis 300 grams, Radix Notoginseng 240 grams, artificial Moschus's 4 grams, Lignum Santali Albi 300 grams, Olibanum 240 grams, Myrrha 240 grams, Radix Angelicae Sinensis 200 grams, Rhizoma Chuanxiong 240 grams, Radix Salviae Miltiorrhizae 240 grams, Radix Curcumae 200 grams are evenly mixed, be ground into fine powder, extremely all by 100 mesh sieves, constant temperature drying was sterilized 1 hour, the Capsules of packing under the sterile working No. 0, every contains crude drug 1 gram, makes 2500 of capsules.
Claims (3)
1. medicine for the treatment of cardiovascular and cerebrovascular disease is to be that crude drug prepares by following parts by weight of traditional Chinese medicines:
Hirudo 160～200 Sanguis Draxonis 100～150 Radix Notoginseng 120～160
Artificial Moschus 1～2 Lignum Santali Albi 100～150 Olibanums 80～120
Myrrha 80～120 Radix Angelicae Sinensis 100～150 Rhizoma Chuanxiongs 100～150
Radix Salviae Miltiorrhizae 120～160 Radix Curcumaes 100～150.
2. the medicine of treatment cardiovascular and cerebrovascular disease according to claim 1 is characterized in that said medicine is made capsule.
3. the preparation method of the medicine of the described treatment cardiovascular and cerebrovascular disease of claim 2, be with the above-mentioned raw materials medicine according to described parts by weight mix homogeneously, be ground into fine powder by 80～100 mesh sieves, sterilization is made in incapsulating.
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| CN2010101746603A CN101816769B (en) | 2010-05-14 | 2010-05-14 | Medicament for treating cardiac, cerebral and vascular diseases |
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| CN2010101746603A CN101816769B (en) | 2010-05-14 | 2010-05-14 | Medicament for treating cardiac, cerebral and vascular diseases |
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| CN101816769B true CN101816769B (en) | 2011-09-07 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104888143A (en) * | 2015-06-29 | 2015-09-09 | 张保菊 | Traditional Chinese medicine prescription for treating angina |
| CN107412672A (en) * | 2017-05-19 | 2017-12-01 | 赵吉林 | A kind of Chinese medicine patch and its preparation method and application |
| CN107050191A (en) * | 2017-06-21 | 2017-08-18 | 许文成 | It is a kind of to treat medicine of senile dementia and preparation method thereof |
| CN107551139A (en) * | 2017-09-30 | 2018-01-09 | 苑学 | A kind of combined traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1660395A (en) * | 2004-12-27 | 2005-08-31 | 杨俭 | Formula of treating apoplexy |
| CN1943771A (en) * | 2005-10-08 | 2007-04-11 | 河北以岭医药研究院有限公司 | The pharmaceutical for treatment of vascular lesion through actions on the NEI network |
| CN101020034A (en) * | 2007-04-02 | 2007-08-22 | 李宏良 | Prepn process of medicine for treating cerebral apoplexy and its sequela |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1660395A (en) * | 2004-12-27 | 2005-08-31 | 杨俭 | Formula of treating apoplexy |
| CN1943771A (en) * | 2005-10-08 | 2007-04-11 | 河北以岭医药研究院有限公司 | The pharmaceutical for treatment of vascular lesion through actions on the NEI network |
| CN101020034A (en) * | 2007-04-02 | 2007-08-22 | 李宏良 | Prepn process of medicine for treating cerebral apoplexy and its sequela |
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