CN101795686A - 治疗口腔干燥的洁齿剂组合物 - Google Patents
治疗口腔干燥的洁齿剂组合物 Download PDFInfo
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- CN101795686A CN101795686A CN200880106037A CN200880106037A CN101795686A CN 101795686 A CN101795686 A CN 101795686A CN 200880106037 A CN200880106037 A CN 200880106037A CN 200880106037 A CN200880106037 A CN 200880106037A CN 101795686 A CN101795686 A CN 101795686A
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Abstract
本发明包括用于治疗或预防口干的口腔用组合物，该组合物具有下列益处：抗菌/抗真菌功效、低刺激性和水分保持。这些组合物可以是牙膏、口腔漱洗液或喷雾剂，并包括一种或多种非离子表面活性剂作为起泡剂，一种或多种广谱抗微生物成分例如氯己定和氯化十六烷基吡啶鎓，及一种或多种口腔表面粘着多糖，该多糖可捕获阳离子活性剂，以帮助该活性剂沉积并保持在口腔表面，从而提供抗微生物功效。
Description
发明背景
口干，临床上称为口腔干燥，被定义为口的干燥主观感觉。它主要由唾液分泌的减少引起，但是该减少的根本机理在患者与患者之间会变化。根据其严重性，口干可引起不适并导致病理状况，例如龋齿和真菌感染，特别是口腔念珠菌病。
因此，对洁齿剂组合物存在需求，该组合物具有口腔卫生及口干预防和治疗性质，以及具有用作此类疾病治疗的能力。
因此，本发明描述了用于口干减轻的口腔用组合物，该组合物具有下列益处：抗菌/抗真菌性质；低刺激性；和水分保持。
发明概述
本发明包括洁齿剂组合物，所述组合物用于治疗或预防口干及至少一种相关病症，此类组合物包含一种或多种表面活性剂；一种或多种抗微生物剂；一种或多种粘合剂。这些洁齿剂组合物具有口腔卫生治疗能力，以及关于口干、牙周病和龋齿的预防作用。
因此，在一个实施方案中，本发明包括治疗或预防口干和至少一种相关病症的方法，该方法包括给予有需要的受试者有效量的口腔护理组合物，该组合物包含一种或多种非离子表面活性剂；一种或多种抗微生物剂；一种或多种粘合剂。
发明详述
本发明包含抗微生物剂和水分保持剂的组合，该组合物具有提供减轻口干的性质。令人惊奇的是，已发现本文所描述的洁齿剂组合物可通过形成笼状结构使阳离子抗微生物活性剂在空间上固定化，以维持活性剂的生物利用度，从而向口腔粘膜提供有效的释放。由于本发明组合物的表面粘着性质和表面涂覆，改善的粘膜相互作用可提供给消费者感觉得到的品质。抗微生物剂在表面的另外物理包埋可产生更实质性的性能。
本发明包括洁齿剂组合物，该组合物用于减轻或预防口腔干燥(即口干)及相关的口腔病症。
如本文使用，术语“洁齿剂”或“多种洁齿剂”指停留在口腔中相对短的时间的产品，其中它们基本上与牙齿的所有表面充分地接触，然后被除去。此类产品的非限制性实例包括牙膏、预防性糊剂、牙齿抛光剂、凝胶剂、专业凝胶剂和其他相关的专业产品，以及口腔洗液、喷雾剂、口腔漱洗剂、牙线、口香糖、锭剂、片剂、可食用食品等。
在一个实施方案中，本发明的洁齿剂组合物是牙膏、口腔漱洗剂、口腔喷雾剂和牙用溶液剂。在另一个实施方案中，该组合物是牙膏或口腔漱洗剂，在另一个实施方案中，该洁齿剂组合物是牙膏。
现在发现，口干和包括洞和感染的相关口腔病症，可以通过给予口腔护理洁齿剂组合物来治疗或预防，该组合物含一种或多种非离子表面活性剂；一种或多种抗微生物剂和一种或多种粘着多糖。
因此，在治疗口干和除去牙斑和牙结石的洁齿剂制剂和组合物中，本发明的口腔护理洁齿剂组合物是有用的。虽然不打算受任何特定理论的束缚，但是似乎口腔护理洁齿剂组合物可根本上减少，甚至阻止口干以及牙斑和牙结石(牙垢)的积聚。也似乎口腔护理洁齿剂组合物可阻止龋齿的脱矿物质作用并消除细菌引起的口腔疾病，而不会有害地影响口腔中的正常微生物菌丛。
本发明的洁齿剂组合物包括一种或多种表面活性剂或相容性表面活性剂的混合物。合适的表面活性剂是在整个宽的pH范围内适当稳定的那些，例如阴离子、阳离子、非离子或两性离子表面活性剂。在示例性的实施方案中，表面活性剂是可用作起泡剂的非离子表面活性剂。
合适的表面活性剂例如在Agricola等的美国专利号3,959,458；Haefele的美国专利号3,937,807和Gieske等的美国专利号4,051,234中有更详细的描述，这些专利通过引用结合到本文中。
在某些实施方案中，在本文中有用的阴离子表面活性剂包括烷基硫酸盐的水溶性盐，该烷基硫酸盐在烷基中具有10-18个碳原子；及磺化的脂肪酸甘油单酸酯的水溶性盐，该脂肪酸具有10-18个碳原子。十二烷基硫酸钠、月桂酰肌氨酸钠和椰子甘油单酸酯磺酸钠是该类型的阴离子表面活性剂的实例。也可采用阴离子表面活性剂的混合物。
在某些实施方案中，本发明包括使用非离子或两性离子表面活性剂，例如普卢兰尼克(pluronic)中代替SLS的甜菜碱。据报道，与SLS相比，这些表面活性剂也具有更低的口腔粘膜刺激性，这可能有益于口干患者。
在另一个实施方案中，可用于本发明的阳离子表面活性剂可以是脂族季铵化合物的衍生物，该季铵化合物具有一个含8-18个碳原子的长烷基链，例如十二烷基三甲基氯化铵、氯化十六烷基吡啶鎓、十六烷基三甲基溴化铵、二-异丁基苯氧基乙基二甲基苄基氯化铵、椰子烷基三甲基亚硝酸铵、十六烷基氟化吡啶鎓及其混合物。
示例性的阳离子表面活性剂有Briner等的美国专利号3,535,421中描述的季铵氟化物，该专利通过引用结合到本文中。某些阳离子表面活性剂也可在组合物中用作杀菌剂。
可用于本发明组合物中的示例性的非离子表面活性剂可以是通过环氧烷基团(在性质上是亲水性的)与有机疏水性化合物缩合制备的化合物，该疏水性化合物在性质上可以是脂族或烷基芳族的。合适的非离子表面活性剂的实例包括但不限于普卢兰尼克、烷基苯酚的聚环氧乙烷缩合物、衍生自环氧乙烷与环氧丙烷和乙二胺反应产物的缩合的产物、脂肪醇的环氧乙烷缩合物、长链叔胺氧化物、长链叔膦氧化物、长链二烷基亚砜及此类物质的混合物。
在某些实施方案中，可用于本发明的两性离子合成表面活性剂可以是脂族季铵、磷鎓和锍化合物的衍生物，其中脂族基团可以是直链或支链的，且其中脂族取代基之一含8-18个碳原子，一个含阴离子水增溶性基团，例如羧基、磺酸根、硫酸根、磷酸根或膦酸根。适用于包含到组合物中的表面活性剂的示例性实例包括但不限于烷基硫酸钠、月桂酰肌氨酸钠、椰油酰胺丙基甜菜碱和聚山梨醇酯20及其组合。
基于总组合物计，表面活性剂或相容性表面活性剂的混合物可以约0.1％-约5.0％的量存在于本发明的组合物中，在另一个实施方案中为约0.3％-约3.0％，在另一个实施方案中为约0.5％-约2.0％重量。
包含在本发明洁齿剂组合物中的抗微生物和抗菌剂可包括但不限于三氯生(5-氯-2-(2，4-二氯苯氧基)-苯酚)；氯己定；二葡萄糖酸氯己定(CHX)；阿来西定、海克替啶(HEX)；血根碱(SNG)；苯扎氯铵；水杨酰苯胺；度米芬；氯化十六烷基吡啶鎓(CPC)；氯化十四烷基吡啶鎓(TPC)；氯化N-十四烷基-4-乙基吡啶鎓(TDEPC)；奥替尼啶；地莫匹醇；辛哌醇及其他哌啶子基衍生物；nicin制剂；锌/亚锡离子试剂；抗生素例如奥格门汀、阿莫西林、四环素、多西环素(deoxycycline)、米诺环素和甲硝唑；过氧化物例如cylium过氧化物、过氧化氢和单过氧邻苯二甲酸镁(magnesium monoperthalate)及其类似物；及上面所列举的抗微生物剂的类似物和盐。
在某些示例性的实施方案中，抗真菌性质可通过广谱抗微生物剂即CHX和CPC之一，及特异性抗真菌感染的抗微生物剂例如制霉菌素、两性霉素B和那他霉素提供。在某些实施方案中，这些组合物治疗与口干病症相关的细菌感染。
基于总组合物计，抗微生物或抗菌剂可以约0.1％-约5.0％的量，在另一个实施方案中以约0.3％-约3.0％的量，在另一个实施方案中以约0.5％-约2.0％重量的量存在于本发明的组合物中。
为了提供水分保持性质，其他表面涂覆/水分保持聚合物也可掺入到所述组合物中。这些聚合物包括但不限于下列化合物家族：硅油(例如二甲聚硅氧烷，已知在皮肤护理中提供表面涂覆和水分保持性质)，及多糖(例如CMC、黄原胶和卡波普)、透明质酸、硫酸皮肤素、硫酸软骨素(chondrotin)、肝素、硫酸类肝素和硫酸角蛋白。
为了帮助将抗微生物剂例如CHX和CPC释放到口腔表面，在配制在最终组合物中之前，通过封囊化或预乳化，将这两种化合物在空间上固定在糖胺聚糖(GAG)分子基质之一或其组合中。它们可通过电荷-电荷相互作用与GAG形成络合物。GAG-CHX或GAG-CPC络合物可随后通过GAG的高度表面粘着性质沉积并保留在口腔表面上。所沉积的络合物将缓慢地释放CPC或CHX，以提供抗微生物作用。
基于总组合物计，多糖可以约0.1％-约5.0％的量存在于本发明的组合物中，在另一个实施方案中为约0.3％-约3.0％，在另一个实施方案中为约0.5％-约2.0％重量。
本发明洁齿剂组合物中的其他组分是亲水性液体溶媒，包括但不限于甘油、丙二醇、聚乙二醇，和疏水性液体溶媒例如甘油三酸酯、甘油二酸酯，及有机油类包括矿物油、精油和脂肪植物油。如本文中使用，精油是通过从各植物的微小分子囊中蒸馏提取的天然物质，是植物免疫系统的一部分，并且还是由植物产生的独立物质。蒸馏法从植物部位中提取挥发油。此类精油是含激素、维生素和在许多水平上起作用的消毒剂的高度浓缩的提取物。这些亲水性和疏水性液体溶媒可单独或组合使用，并且可以基于整个组合物计约2-约50wt.％(在包含液体溶媒的组合物的情况中)，尤其是约10-约35wt.％的比例加入。
使用一种或多种这些液体溶媒，本发明的口腔用组合物可以配制成使用形式例如凝胶剂、液体或糊剂。
本发明的洁齿剂组合物也含有香料组分，通常为天然香料或芳香油和/或草药提取物和油的形式。这些香料组分不仅可以用于给洁齿剂组合物赋予可口的香味，而且可以同时用作天然抗菌剂和防腐剂。适合用于本发明的油包括但不限于柠檬油(citric oil)、柠檬油、梨莓油、柠檬草油、橙油、甜橙油、葡萄柚油、石榴油、杏油提取物、橘子提取物、桔柚油、欧薄荷油、绿薄荷油、鼠尾草油、迷迭香油、肉桂油、冬青油、丁香油、桉树油、姜油、黄樟油、薄荷醇、arvensis薄荷油、合成薄荷香料和油、香芹酮、丁香酚、丁子香酚甲醚、水杨酸甲酯、甲基丁香酚、百里酚、茴香脑、蓍草(millefolium)提取物、洋甘菊、熏衣草油、没药、丁香酚、茶树油、鼠尾草油、锦葵、柠檬烯、罗勒烯、正癸醇、香茅醇、α-萜品醇、里哪醇、乙基里哪醇、百里香、杏仁油、肉豆蔻和香草醛。这些香料中的任一种或者这些香料中的两种或多种的混合物可用于洁齿剂组合物中。本发明的洁齿剂组合物也可任选含有甜味剂例如糖精钠、丁磺氨钾、甘草甜素、紫苏亭、祝马丁、天冬氨酰苯基丙氨酰甲酯和木糖醇。基于总组合物计，其含量可以是约3％-约20％重量，或约4％-约15％重量的量。
所述洁齿剂组合物可包括一种或多种可用于本发明实践中的研磨剂，包括但不限于二氧化硅研磨剂，例如具有最大到约20微米的平均粒度的沉淀二氧化硅，例如由J.M.Huber销售的
研磨剂材料应该是一种这样的材料，该材料能与有关组合物相容，但不过度地磨损牙质。合适的研磨剂包括例如二氧化硅包括凝胶和沉淀物；不溶性聚偏磷酸盐(酯)、水合氧化铝、树脂研磨剂例如聚合树脂(例如尿素类、三聚氰胺类、交联环氧化物类、酚醛树脂类等)及其混合物。
有用的研磨剂也包括偏磷酸钠、偏磷酸钾、磷酸三钙、二水合磷酸二钙、硅酸铝、煅烧氧化铝、膨润土或其他含硅物质或其组合。本文中可使用的二氧化硅研磨剂抛光材料以及其他研磨剂，通常具有范围在约0.1-30微米之间，在5-15微米之间的平均粒度。二氧化硅研磨剂可来自沉淀二氧化硅或硅胶，例如Pader等的美国专利号3,538,230和Digiulio的美国专利号3,862,307中描述的二氧化硅干凝胶，这两个专利通过引用结合到本文中。特殊的二氧化硅干凝胶由W.R.Grace &Co.，Davison Chemical Division以商品名
销售。沉淀二氧化硅材料包括由J.M.Huber Corp.以商品名
销售的那些，包括带有Zeodent 115和119名称的二氧化硅。这些二氧化硅研磨剂在Wason的美国专利号4,340,583中有描述，该专利通过引用结合到本文中。
适用于本发明使用的另外的二氧化硅研磨剂包括但不限于硅胶、沉淀二氧化硅、硅酸盐和水合二氧化硅。适用于本发明使用的硅胶有水凝胶、水合凝胶(hydrous gel)、干凝胶和气凝胶，例如本领域已知的那些和美国专利号6,440,397中描述的那些，该专利通过引用结合到本文中。沉淀二氧化硅是本领域已知的那些，例如美国专利号5,589,160中描述的合适的洁齿剂类型的沉淀二氧化硅，该专利的内容通过引用结合到本文中。合适的硅酸盐是适用于洁齿剂组合物使用的那些天然存在或合成的硅酸盐中的任何硅酸盐。这些二氧化硅研磨剂可单独使用或组合使用。在某些实施方案中，本发明使用的二氧化硅研磨剂包括硅胶。二氧化硅研磨剂可与钙盐一起使用或代替钙盐组分使用。
水可任选掺入到本发明的牙膏组合物中。用于商业上合适的牙膏的制剂中的水应该是去离子水并且无有机杂质。本文中，水通常可占组合物重量的约0％-约40％。
本发明的洁齿剂组合物也可任选包括防龋剂。防龋剂是水溶性氟化物离子源。此类氟化物离子源的数目是大的并且对本领域技术人员而言是众所周知的，并包括美国专利号3,535,421中公开的那些，该专利通过引用结合到本文中。氟化物离子源物质包括氟化钠、氟化钾、一氟磷酸钠及其混合物。各种产生氟化物离子的物质可用作本发明组合物中可溶性氟化物的来源。合适的产生氟化物离子的物质的实例可在Briner等的美国专利号3,535,421、Parran，Jr.等的美国专利号4,885,155和Widder等的美国专利号3,678,154中发现，这些专利通过引用结合到本文中。
代表性的氟化物离子源包括但不限于氟化亚锡、氟化钠、氟化钾、一氟磷酸钠、氟硅酸钠、一氟磷酸钠(MFP)、氟硅酸铵，以及氟化锡例如氟化亚锡和氯化亚锡及其组合。某些特定的实施方案包括氟化亚锡或氟化钠及其混合物。
在某些实施方案中，本发明的口腔护理条状物或带状口腔用组合物也可含有足够提供约25ppm-5,000ppm氟化物离子的量的氟化物离子源或提供氟的成分。
氟化物离子源在一个实施方案中可以该组合物重量的约0.01％-3.0％的水平，或者在另一个实施方案中以约0.03％-1.0％的水平加入到本发明的组合物中。单个条或带的剂量(即单剂量)为约0.0001-0.003％(重量)，0.0005-0.003％(重量)，在另一个实施方案中为约0.001-0.02％(重量)。
本发明的洁齿剂组合物也可任选包括一种或多种防结石(防牙垢)剂。可用于本发明的洁齿剂组合物中的防结石剂包括抗微生物剂例如氯己定、尼达霉素和三氯生，金属和金属盐例如柠檬酸锌，维生素C、二膦酸盐、焦磷酸三氯生、焦磷酸盐、多磷酸盐、聚丙烯酸盐和其他聚羧酸盐、聚环氧琥珀酸盐、乙二胺四乙酸(EDTA)、次氮基三乙酸及相关化合物、聚膦酸盐和聚焦磷酸盐例如六偏磷酸钠，以及本领域技术人员已知的其他防结石剂，例如K.J.Fairbrother等，″防结石剂″Journal of Clinical Periodontology Vol.27，pp.285 301(2000)中描述的那些。
营养素和维生素也可任选加入到本发明的洁齿剂组合物中。此类物质可包括叶酸、类维生素A(维生素A)、维生素B(B1-thyamin、B2-核黄素、B3-烟酸、B5-泛酸、B6-吡哆醇、B7-生物素、B8/B9/Bc-叶酸、B12-氰钴维生素)、维生素C(抗坏血酸、抗坏血酸钠)、维生素E、维生素E类似物(dl-α-醋酸生育酚、琥珀酸生育酚、烟酸生育酚)和锌。
各种其他添加剂也可任选配制到本发明的洁齿剂中，例如牙齿脱敏剂(例如钾盐和锶盐)、缩合的防牙垢剂例如四焦磷酸钠和钾、增白剂例如氧化铝和过氧化钙、清除剂例如碳酸氢钠、颜料和染料，例如蓝15-C174160、绿7-C174260、红4-CI12085和40 CI16035、黄115CI47005:1和5 CI19140，及洋红5 CI16035)，以及添加剂例如云母和闪光物(sparkles)。如同其他任选的洁齿剂添加剂一样，可以适用于洁齿剂组合物的量使用这些成分中任何一种或这些成分中两种或多种的混合物。
除了上述组分外，本发明的洁齿剂组合物还可含各种任选的成分和通常用于口腔用制剂例如洁齿剂的溶媒。这些任选的组分包括但不限于此类组分如研磨剂、表面活性剂、增稠剂、缓冲剂、湿润剂、防腐剂和抗生素及防龋剂。下面进一步详细描述的所有这些添加剂一般是常用的，并且为本领域技术人员所熟知。
本发明的洁齿剂组合物中另一种任选的组分是湿润剂。湿润剂起避免组合物例如牙膏组合物在暴露于空气中时变硬的作用，并起赋予口腔洗液和牙膏组合物口腔湿润感的作用。某些湿润剂也可赋予牙膏和口腔洗液组合物期望的香料甜味。用于本发明的组合物中的合适的湿润剂包括可食用多元醇例如甘油、山梨醇、木糖醇、聚乙二醇和丙二醇。
缓冲剂是本发明的洁齿剂组合物中另一种任选的组分。缓冲剂起使组合物的pH保持在一定范围内的作用。用于本发明的洁齿剂组合物中的合适的缓冲剂包括可溶性磷酸盐。
本发明的洁齿剂组合物中其他任选的组分是防腐剂，例如防止洁齿剂组合物中微生物生长的那些。合适的防腐剂包括但不限于尼泊金甲酯、尼泊金丙酯、苯甲酸盐和醇例如乙醇。
粘合剂和增稠剂也可任选用于本发明的洁齿剂组合物中，特别是用于牙膏组合物中。在某些实施方案中，粘合剂和增稠剂包括但不限于角叉菜胶(例如Viscarin、角叉菜等)、纤维素衍生物例如羟乙基纤维素、羧甲基纤维素钠，及羧甲基羟丙基纤维素钠、羧基乙烯基聚合物、天然胶例如刺梧桐胶、阿拉伯胶和黄芪胶、多糖胶例如黄原胶、热解法二氧化硅和胶体硅酸镁铝。
意外地发现，本发明的洁齿剂组合物具有减少、治疗或预防口干的能力。根据本发明的组合物可通过将其涂覆到口腔中并刷牙齿和/或牙龈使用。为了这样的刷牙，使用牙刷，该牙刷提供有去除牙斑的刷毛并与牙龈按摩部分组合，虽然也可使用常规牙刷，即具有去除牙斑的刷毛的牙刷或具有按摩部分的牙刷。
实施例
实施例1
示例性实施例1提供了牙膏制剂的非限定性实例。下列成分以下面描述的比例混合：
| 成分 | ％Wt./Wt. |
| 水 | 3.78 |
| 氟化钠 | 0.26 |
| 糖精钠 | 0.37 |
| 山梨醇 | 67.1 |
| 甘油 | 7.46 |
| PEG 600 | 1.5 |
| 焦磷酸四钠 | 0.53 |
| 黄原胶 | 0.23 |
| 羧甲基纤维素 | 0.8 |
| 二氧化硅 | 12.5 |
| 透明质酸 | 0.5 |
| 普卢兰尼克 | 1 |
| 甜菜碱表面活性剂 | 0.37 |
| 成分 | ％Wt./Wt. |
| 香料 | 1.1 |
| 羧甲基纤维素 | 0.5 |
| 二甲聚硅氧烷 | 2 |
实施例2
示例性实施例2提供了口腔漱洗液制剂的非限定性实例。下列成分以下面给出的比例混合：
| 成分 | ％Wt./Wt. |
| 水 | 84.41 |
| 糖精钠 | 0.01 |
| 甘油 | 15 |
| 透明质酸 | 0.05 |
| 羧甲基纤维素 | 0.08 |
| 普卢兰尼克 | 0.1 |
| 香料 | 0.1 |
| 氯化十六烷基吡啶鎓 | 0.05 |
| 二甲聚硅氧烷 | 0.2 |
Claims (22)
1.一种治疗和/或预防口干及至少一种相关病症的方法，所述方法包括给予有需要的受试者有效量的组合物，该组合物包含至少一种表面活性剂；至少一种抗微生物剂；和至少一种粘合剂。
2.权利要求1的方法，其中所述组合物适用于经口给予。
3.权利要求1的方法，其中组合物是牙膏。
4.权利要求1的方法，其中组合物是口腔洗液。
5.权利要求1的方法，其中组合物是口腔喷雾剂。
6.权利要求1的方法，其中所述至少一种相关病症选自细菌感染、真菌感染和原生动物感染。
7.权利要求1的方法，其中所述组合物对口腔具有低刺激性。
8.权利要求1的方法，其中所述至少一种表面活性剂是非离子表面活性剂。
9.权利要求1的方法，其中所述至少一种表面活性剂为椰油酰胺丙基甜菜碱。
10.权利要求1的方法，其中所述至少一种抗微生物剂选自三氯生(5-氯-2-(2，4-二氯苯氧基)-苯酚)；氯己定；二葡萄糖酸氯己定；阿来西定、海克替啶；血根碱；苯扎氯铵；水杨酰苯胺；度米芬；氯化十六烷基吡啶鎓；氯化十四烷基吡啶鎓；氯化N-十四烷基-4-乙基吡啶鎓；奥替尼啶；地莫匹醇；辛哌醇及其他哌啶子基衍生物；nicin制剂；锌/亚锡离子试剂；抗生素例如奥格门汀、阿莫西林、四环素、多西环素、米诺环素和甲硝唑；过氧化物例如cylium过氧化物、过氧化氢，和单过氧邻苯二甲酸镁及上面所列举的抗微生物剂的类似物和盐。
11.权利要求1的方法，其中所述至少一种粘合剂选自硅油、多糖、CMC、黄原胶、卡波普、透明质酸、硫酸皮肤素、硫酸软骨素、肝素、硫酸类肝素和硫酸角蛋白。
12.权利要求1的方法，其中所述组合物还包含至少一种表面涂覆/水分保持聚合物。
13.权利要求1的方法，其中所述组合物还包含至少一种氟离子源。
14.权利要求12的方法，其中所述至少一种相关病症是龋齿。
15.权利要求1的方法，其中所述组合物还包含至少一种研磨剂。
16.权利要求1的方法，其中所述至少一种抗微生物剂占所述组合物的约0.1-约5wt.％。
17.权利要求1的方法，其中所述至少一种表面活性剂占所述组合物的约0.1-约3wt.％。
18.权利要求1的方法，其中所述至少一种粘合剂占所述组合物的约0.1-约3wt.％。
19.一种治疗和/或预防口干及至少一种相关病症的方法，所述方法包括给予有需要的受试者有效量的组合物，该组合物包含至少一种表面活性剂；至少一种抗微生物剂；和至少一种粘合剂，其中所述至少一种抗微生物剂选自苯扎氯铵；水杨酰苯胺；度米芬；氯化十六烷基吡啶鎓；氯化十四烷基吡啶鎓；氯化N-十四烷基-4-乙基吡啶鎓；奥替尼啶；地莫匹醇；辛哌醇及哌啶子基衍生物。
20.权利要求19的方法，其中所述至少一种相关病症是细菌感染。
21.权利要求19的方法，其中所述至少一种相关病症是真菌感染。
22.权利要求19的方法，其中所述至少一种抗微生物剂是氯化十六烷基吡啶鎓。
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| US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
| WO2016172553A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
| US10370403B2 (en) | 2015-04-22 | 2019-08-06 | Brigham Young University | Methods for the synthesis of ceragenins |
| CZ28634U1 (cs) | 2015-05-05 | 2015-09-14 | Contipro Pharma A.S. | Dentální přípravek na bázi hyaluronanu a oktenidin dihydrochloridu |
| US9434759B1 (en) | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
| US12318404B2 (en) | 2016-01-19 | 2025-06-03 | Reoxcyn LLC | Hypochlorite formulations for wound healing |
| US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
| US11857674B2 (en) | 2016-05-18 | 2024-01-02 | Reoxcyn, Llc | Lubricant formulations |
| US9474768B1 (en) | 2016-05-18 | 2016-10-25 | Reoxcyn Discoveries Group, Inc. | Lubricant formulations |
| KR102677610B1 (ko) | 2016-07-11 | 2024-06-20 | 삼성전자주식회사 | 피리디늄계 복합체, 및 이를 포함하는 성형품 |
| US9833471B1 (en) | 2016-09-15 | 2017-12-05 | Reoxcyn Discoveries Group, Inc. | Hypochlorous acid-based hand sanitizer |
| US20180200165A1 (en) | 2017-01-16 | 2018-07-19 | Reoxcyn Innovation Group, Llc | Dentifrice formulations and methods of oral care |
| EP3366272B1 (en) * | 2017-02-28 | 2019-10-30 | Unilever PLC | Oral care compositions |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
| JP7455317B2 (ja) * | 2017-06-30 | 2024-03-26 | 小林製薬株式会社 | 口腔用組成物 |
| WO2019126703A1 (en) | 2017-12-22 | 2019-06-27 | Ecolab Usa Inc. | Antimicrobial compositions with enhanced efficacy |
| JP7140636B2 (ja) * | 2018-11-02 | 2022-09-21 | アース製薬株式会社 | 口腔用薬液噴霧製品 |
| EP3902523A1 (en) * | 2018-12-29 | 2021-11-03 | 3M Innovative Properties Company | Oral articles and methods of use |
| EP3941422A4 (en) * | 2019-03-18 | 2023-04-19 | Sunstar Americas, Inc. | ORAL CARE COMPOSITION |
| ES3028342T3 (en) * | 2019-04-10 | 2025-06-18 | Black Tulip Man Inc | Oral rinse compositions for reducing pathogens underlying and for treating periodontal disease and oral malodor in the canine |
| US11191709B2 (en) | 2019-04-26 | 2021-12-07 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
| US12186328B2 (en) | 2019-05-23 | 2025-01-07 | Brigham Young University | Use of CSA compounds to stimulate stem cells and hair growth |
| BR112021024274A2 (pt) | 2019-06-14 | 2022-01-11 | Procter & Gamble | Composições para tratamento bucal sem enxágue |
| MX2021015131A (es) | 2019-06-14 | 2022-01-24 | Procter & Gamble | Composiciones para el cuidado bucal para usar y no enjuagar. |
| JP2022538521A (ja) | 2019-06-14 | 2022-09-05 | ザ プロクター アンド ギャンブル カンパニー | 洗い流さない口腔ケア組成物 |
| EP4106716A4 (en) | 2020-02-18 | 2024-03-13 | Sunstar Americas, Inc. | ORAL CARE COMPOSITION |
| RU2761303C1 (ru) * | 2021-03-15 | 2021-12-07 | Общество с ограниченной ответственностью "Дубна-Биофарм". | Способ получения фармацевтической композиции и фармацевтическая композиция для лечения и профилактики заболеваний пародонта |
| DE102021108264A1 (de) | 2021-03-31 | 2022-10-06 | G. Pohl-Boskamp Gmbh & Co. Kg | Zusammensetzung zur topischen Anwendung an einem Subjekt |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3678154A (en) * | 1968-07-01 | 1972-07-18 | Procter & Gamble | Oral compositions for calculus retardation |
| US3535421A (en) * | 1968-07-11 | 1970-10-20 | Procter & Gamble | Oral compositions for calculus retardation |
| US3959458A (en) * | 1973-02-09 | 1976-05-25 | The Procter & Gamble Company | Oral compositions for calculus retardation |
| US3937807A (en) * | 1973-03-06 | 1976-02-10 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
| US3862307A (en) * | 1973-04-09 | 1975-01-21 | Procter & Gamble | Dentifrices containing a cationic therapeutic agent and improved silica abrasive |
| US4051234A (en) * | 1975-06-06 | 1977-09-27 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
| US4233288A (en) * | 1979-03-12 | 1980-11-11 | Cornell John A | Gum emulsified liquid package for delivering and preserving liquid content in the mouth |
| US4340583A (en) * | 1979-05-23 | 1982-07-20 | J. M. Huber Corporation | High fluoride compatibility dentifrice abrasives and compositions |
| US4885155A (en) * | 1982-06-22 | 1989-12-05 | The Procter & Gamble Company | Anticalculus compositions using pyrophosphate salt |
| IT1229075B (it) * | 1985-04-05 | 1991-07-17 | Fidia Farmaceutici | Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico |
| US4945087A (en) * | 1988-03-31 | 1990-07-31 | Warner-Lambert Company | Taste masking of thymol |
| SE9101076L (sv) * | 1991-04-10 | 1992-10-11 | Camurus Ab | Saliversaettningsmedel |
| US5541165A (en) * | 1994-09-27 | 1996-07-30 | Turgeon; Jean A. | Saliva substitute |
| US6159459A (en) * | 1995-05-01 | 2000-12-12 | Colgate Palmolive Company | Oral lubricating composition |
| US5589160A (en) * | 1995-05-02 | 1996-12-31 | The Procter & Gamble Company | Dentifrice compositions |
| US5658554A (en) * | 1995-06-01 | 1997-08-19 | Colgate-Palmolive Company | Mouth moistener for the relief of dry mouth condition |
| US6294155B1 (en) * | 1998-04-08 | 2001-09-25 | W. R. Grace & Co. -Conn. | Abrasive silica compositions and dentifrice compositions prepared therefrom |
| US6113629A (en) * | 1998-05-01 | 2000-09-05 | Micrus Corporation | Hydrogel for the therapeutic treatment of aneurysms |
| EP1123695A3 (en) * | 2000-01-28 | 2001-09-26 | Unilever N.V. | Oral composition comprising capsules containing keratin |
| ES2186569B1 (es) * | 2001-09-28 | 2004-09-16 | Lacer, S.A. | Composiciones para el alivio de la xerostomia y el tratamiento de los trastornos asociados con la misma. |
| US6579513B1 (en) * | 2002-01-03 | 2003-06-17 | Playtex Products, Inc. | Hygiene mouthspray composition |
| RU2220729C2 (ru) * | 2002-01-31 | 2004-01-10 | Общество с ограниченной ответственностью "Научный Центр системных исследований и технологий 2000" | Гелевая композиция, используемая в стоматологии |
| CA2491054A1 (en) * | 2002-07-03 | 2004-01-15 | Pericor Science, Inc. | Compositions of hyaluronic acid and methods of use |
| EP2263644A2 (en) * | 2004-08-02 | 2010-12-22 | Glaxo Group Limited | Novel composition for treating xerostomia |
| JP4836227B2 (ja) * | 2005-03-30 | 2011-12-14 | Ｎｓファーファ・ジャパン株式会社 | 口腔内乾燥防止および口腔内刺激緩和用組成物 |
| ITBO20050388A1 (it) * | 2005-06-06 | 2006-12-07 | Alfa Wassermann Spa | Formulazione mucoadesive utili in dispositivi medici in preparazioni farmaceutiche |
| RU2286764C1 (ru) * | 2005-06-16 | 2006-11-10 | Георгий Георгиевич Ростиашвили | Средство "гиалудент" пролонгированного действия для лечения воспалительных заболеваний полости рта |
-
2007
- 2007-09-06 US US11/850,955 patent/US20090068122A1/en not_active Abandoned
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2008
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- 2008-07-17 MX MX2009012775A patent/MX2009012775A/es not_active Application Discontinuation
- 2008-07-17 JP JP2010524069A patent/JP2010538074A/ja active Pending
- 2008-07-17 AU AU2008296757A patent/AU2008296757C1/en not_active Ceased
- 2008-07-17 EP EP08781951A patent/EP2187885A1/en not_active Withdrawn
- 2008-07-17 RU RU2010112987/15A patent/RU2452465C2/ru active
- 2008-07-17 MY MYPI20094907 patent/MY151338A/en unknown
- 2008-07-17 WO PCT/US2008/070285 patent/WO2009032406A1/en active Application Filing
- 2008-07-17 CA CA2690011A patent/CA2690011C/en not_active Expired - Fee Related
- 2008-07-17 BR BRPI0813970-9A2A patent/BRPI0813970A2/pt not_active IP Right Cessation
- 2008-09-05 TW TW097133998A patent/TWI477269B/zh not_active IP Right Cessation
- 2008-09-05 AR ARP080103882A patent/AR068379A1/es unknown
-
2009
- 2009-12-14 ZA ZA2009/08898A patent/ZA200908898B/en unknown
- 2009-12-23 CO CO09147466A patent/CO6321137A2/es not_active Application Discontinuation
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102085369B (zh) * | 2011-01-28 | 2012-07-04 | 武汉耦合医学科技有限责任公司 | 一种口腔干燥症凝胶医疗用品及其制备方法 |
| CN102085369A (zh) * | 2011-01-28 | 2011-06-08 | 武汉耦合医学科技有限责任公司 | 一种口腔干燥症凝胶医疗用品及其制备方法 |
| CN105748507A (zh) * | 2016-02-26 | 2016-07-13 | 陕西恒远生物科技有限公司 | 一种缓解口腔干燥的凝胶剂 |
| CN105748507B (zh) * | 2016-02-26 | 2018-04-17 | 陕西恒远生物科技有限公司 | 一种缓解口腔干燥的凝胶剂 |
| CN109803728A (zh) * | 2016-10-17 | 2019-05-24 | 高露洁-棕榄公司 | 具有增强的外观和形式的口腔护理组合物 |
| CN110996891A (zh) * | 2017-08-04 | 2020-04-10 | 实验室金公司 | 包含氯己定的凝胶 |
| CN110996891B (zh) * | 2017-08-04 | 2023-02-28 | 实验室金公司 | 包含氯己定的凝胶 |
| CN109381364A (zh) * | 2017-08-09 | 2019-02-26 | 杭州孚乐西生物技术有限公司 | 一种含血根碱的牙膏 |
| CN110787078A (zh) * | 2018-08-20 | 2020-02-14 | 惠州市九惠制药股份有限公司 | 一种含有甘草黄酮的牙膏及其制备方法和应用 |
| WO2020248239A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| WO2020248232A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| CN110840312A (zh) * | 2019-11-27 | 2020-02-28 | 铜陵麟安生物科技有限公司 | 一种抗菌杀毒的超柔地板湿巾及其制备方法 |
| CN111662616A (zh) * | 2020-07-09 | 2020-09-15 | 周红岩 | 一种热固性树脂组合物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| MY151338A (en) | 2014-05-15 |
| EP2187885A1 (en) | 2010-05-26 |
| MX2009012775A (es) | 2009-12-10 |
| TWI477269B (zh) | 2015-03-21 |
| JP2010538074A (ja) | 2010-12-09 |
| AR068379A1 (es) | 2009-11-11 |
| CA2690011C (en) | 2015-03-31 |
| RU2010112987A (ru) | 2011-10-20 |
| AU2008296757A1 (en) | 2009-03-12 |
| BRPI0813970A2 (pt) | 2015-01-06 |
| WO2009032406A1 (en) | 2009-03-12 |
| CA2690011A1 (en) | 2009-03-12 |
| RU2452465C2 (ru) | 2012-06-10 |
| AU2008296757B2 (en) | 2011-06-23 |
| AU2008296757C1 (en) | 2012-02-02 |
| TW200927183A (en) | 2009-07-01 |
| ZA200908898B (en) | 2014-11-26 |
| CO6321137A2 (es) | 2011-09-20 |
| US20090068122A1 (en) | 2009-03-12 |
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