IT1229075B - Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico - Google Patents

Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico

Info

Publication number: IT1229075B
Authority: IT; Italy
Prior art keywords: hyaluronic acid; contg; vehicle; compsn; acid deriv
Prior art date: 1985-04-05

Application number

IT8547924A

Other languages

English (en)

Other versions

IT8547924A0 (it

Inventor

Della Valle Francesco

Romeo Aurelio

Lorenzi Silvana

Original Assignee

Fidia Farmaceutici

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-05

Filing date

1985-04-05

Publication date

1991-07-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36694284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1229075(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-04-05 Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici

1985-04-05 Priority to IT8547924A priority Critical patent/IT1229075B/it

1985-04-05 Publication of IT8547924A0 publication Critical patent/IT8547924A0/it

1985-04-09 Priority to CN85102921A priority patent/CN85102921B/zh

1985-12-23 Priority claimed from IT48980/85A external-priority patent/IT1184675B/it

1986-03-25 Priority to IL78263A priority patent/IL78263A0/xx

1986-03-27 Priority to AT86302291T priority patent/ATE98495T1/de

1986-03-27 Priority to EP86302291A priority patent/EP0197718B2/en

1986-03-27 Priority to EP19930200175 priority patent/EP0555898A3/en

1986-03-27 Priority to IE84786A priority patent/IE64440B1/en

1986-03-27 Priority to IN248/CAL/86A priority patent/IN165867B/en

1986-03-27 Priority to DE3689384T priority patent/DE3689384T3/de

1986-03-31 Priority to PH33597A priority patent/PH29979A/en

1986-04-01 Priority to FI861395A priority patent/FI83966C/fi

1986-04-01 Priority to FR868604601A priority patent/FR2579895B1/fr

1986-04-02 Priority to DK149886A priority patent/DK149886A/da

1986-04-03 Priority to BE1/011467A priority patent/BE904547A/fr

1986-04-03 Priority to ZA862463A priority patent/ZA862463B/xx

1986-04-03 Priority to HU861402A priority patent/HU204202B/hu

1986-04-03 Priority to LU86386A priority patent/LU86386A1/fr

1986-04-03 Priority to US06/847,632 priority patent/US4736024A/en

1986-04-03 Priority to AR86303552A priority patent/AR245369A1/es

1986-04-04 Priority to CA000617112A priority patent/CA1341418C/en

1986-04-04 Priority to KR1019860002595A priority patent/KR910006810B1/ko

1986-04-04 Priority to CH1340/86A priority patent/CH672886A5/fr

1986-04-04 Priority to ES553714A priority patent/ES8800055A1/es

1986-04-04 Priority to JP61079060A priority patent/JP2585216B2/ja

1986-04-04 Priority to NO861331A priority patent/NO174277C/no

1986-04-04 Priority to PT82342A priority patent/PT82342B/pt

1986-04-04 Priority to AU55662/86A priority patent/AU592077B2/en

1986-04-04 Priority to CA000505909A priority patent/CA1340825C/en

1986-04-04 Priority to CA000617080A priority patent/CA1341087C/en

1988-04-02 Priority to NZ215676A priority patent/NZ215676A/xx

1989-02-23 Priority to IN155/CAL/89A priority patent/IN169540B/en

1989-12-19 Priority to US07/452,681 priority patent/US5166331A/en

1991-07-17 Publication of IT1229075B publication Critical patent/IT1229075B/it

1991-07-17 Application granted granted Critical

1992-08-19 Priority to US07/931,949 priority patent/US5442053A/en

1993-06-22 Priority to IL106094A priority patent/IL106094A0/xx

1995-04-21 Priority to US08/426,905 priority patent/US5631241A/en

1996-06-12 Priority to JP8151346A priority patent/JP2677778B2/ja

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Inorganic Chemistry (AREA)
Communicable Diseases (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Virology (AREA)
Biotechnology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

IT8547924A 1982-09-28 1985-04-05 Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico IT1229075B (it)

Priority Applications (36)

Application Number	Priority Date	Filing Date	Title
IT8547924A IT1229075B (it)	1985-04-05	1985-04-05	Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
CN85102921A CN85102921B (zh)	1985-04-05	1985-04-09	制备具有药物作用的透明质酸组份及含该组份的药物的方法
IL78263A IL78263A0 (en)	1985-04-05	1986-03-25	New medicaments for topical use comprising hyaluronic acid and its derivatives
DE3689384T DE3689384T3 (de)	1985-04-05	1986-03-27	Arzneimittel zur örtlichen Anwendung
IN248/CAL/86A IN165867B (it)	1985-04-05	1986-03-27
EP86302291A EP0197718B2 (en)	1985-04-05	1986-03-27	New medicaments for topical use
AT86302291T ATE98495T1 (de)	1985-04-05	1986-03-27	Arzneimittel zur topischen anwendung.
EP19930200175 EP0555898A3 (en)	1985-04-05	1986-03-27	Medicaments for non-topical use
IE84786A IE64440B1 (en)	1985-04-05	1986-03-27	New medicaments for topical use
PH33597A PH29979A (en)	1985-04-05	1986-03-31	New medicaments for topical use
FI861395A FI83966C (fi)	1985-04-05	1986-04-01	Foerfarande foer framstaellning av farmaceutiskt aktiva hyaluronsyrasalter.
FR868604601A FR2579895B1 (it)	1985-04-05	1986-04-01
DK149886A DK149886A (da)	1985-04-05	1986-04-02	Topiske medikamenter
US06/847,632 US4736024A (en)	1985-04-05	1986-04-03	Process for preparing salt of hyaluronic acid with a pharmaceutically active substance
AR86303552A AR245369A1 (es)	1985-04-05	1986-04-03	Procedimiento para la fabricacion de una sal del acido hialuronico.
LU86386A LU86386A1 (fr)	1985-04-05	1986-04-03	Nouveaux medicaments a usage topique
ZA862463A ZA862463B (en)	1985-04-05	1986-04-03	New medicaments for topical use
HU861402A HU204202B (en)	1985-04-05	1986-04-03	Process for producing new, local pharmaceutical compositions
BE1/011467A BE904547A (fr)	1985-04-05	1986-04-03	Nouveaux medicaments a usage topique.
CA000617080A CA1341087C (en)	1983-07-13	1986-04-04	Medicaments including hyaluronic acid as a drug delivery system
KR1019860002595A KR910006810B1 (ko)	1985-04-05	1986-04-04	신규한 히알루론산염의 제조방법
AU55662/86A AU592077B2 (en)	1985-04-05	1986-04-04	Hydralonic acid compositions
CA000505909A CA1340825C (en)	1985-04-05	1986-04-04	Hyaluronic acid fraction for use as a drug delivery system for medicaments
CH1340/86A CH672886A5 (it)	1985-04-05	1986-04-04
ES553714A ES8800055A1 (es)	1985-04-05	1986-04-04	Procedimiento para la preparacion de una composicion que contiene una sal de acido hialuronico.
JP61079060A JP2585216B2 (ja)	1985-04-05	1986-04-04	新規医薬組成物
NO861331A NO174277C (no)	1985-04-05	1986-04-04	Fremgangsmåte for fremstilling av et hyaluronsyresalt
PT82342A PT82342B (pt)	1985-04-05	1986-04-04	Processo para a preparacao de derivados do acido hialuronico
CA000617112A CA1341418C (en)	1985-04-05	1986-04-04	Substantially-pure non-inflammatory hyaluronic acid
NZ215676A NZ215676A (en)	1985-04-05	1988-04-02	Topical pharmaceutical compositions with vehicle containing hyaluronic acid derivatives; preparation or hyaluronic acid salts
IN155/CAL/89A IN169540B (it)	1985-04-05	1989-02-23
US07/452,681 US5166331A (en)	1983-10-10	1989-12-19	Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US07/931,949 US5442053A (en)	1982-09-28	1992-08-19	Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions
IL106094A IL106094A0 (en)	1985-04-05	1993-06-22	Salts of hyaluronic acid
US08/426,905 US5631241A (en)	1983-10-10	1995-04-21	Pharmaceutical compositions containing hyaluronic acid fractions
JP8151346A JP2677778B2 (ja)	1985-04-05	1996-06-12	新規医薬組成物

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT8547924A IT1229075B (it)	1985-04-05	1985-04-05	Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
CN85102921A CN85102921B (zh)	1985-04-05	1985-04-09	制备具有药物作用的透明质酸组份及含该组份的药物的方法
IT48980/85A IT1184675B (it)	1985-12-23	1985-12-23	Procedimento per la preparazione di sali dell'acido ialuronico

Publications (2)

Publication Number	Publication Date
IT8547924A0 IT8547924A0 (it)	1985-04-05
IT1229075B true IT1229075B (it)	1991-07-17

Family

ID=36694284

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8547924A IT1229075B (it)	1982-09-28	1985-04-05	Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico

Country Status (27)

Country	Link
US (1)	US4736024A (it)
EP (2)	EP0555898A3 (it)
JP (2)	JP2585216B2 (it)
KR (1)	KR910006810B1 (it)
CN (1)	CN85102921B (it)
AR (1)	AR245369A1 (it)
AT (1)	ATE98495T1 (it)
AU (1)	AU592077B2 (it)
BE (1)	BE904547A (it)
CA (2)	CA1340825C (it)
CH (1)	CH672886A5 (it)
DE (1)	DE3689384T3 (it)
DK (1)	DK149886A (it)
ES (1)	ES8800055A1 (it)
FI (1)	FI83966C (it)
FR (1)	FR2579895B1 (it)
HU (1)	HU204202B (it)
IE (1)	IE64440B1 (it)
IL (1)	IL78263A0 (it)
IN (1)	IN165867B (it)
IT (1)	IT1229075B (it)
LU (1)	LU86386A1 (it)
NO (1)	NO174277C (it)
NZ (1)	NZ215676A (it)
PH (1)	PH29979A (it)
PT (1)	PT82342B (it)
ZA (1)	ZA862463B (it)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1186772B (it) *	1985-10-10	1987-12-16	Crinos Industria Farmaco	Composto ad attivita' pilostimolante
WO1987005517A1 (en) *	1986-03-14	1987-09-24	Bio-Technology General Corp.	Heavy metal salts of hyaluronic acid useful as antimicrobial agents
US5668116A (en) *	1987-03-19	1997-09-16	Anthropharm Pty. Limited	Anti-inflammatory compounds and compositions
JP2511829B2 (ja) *	1987-03-19	1996-07-03	アースロファームピーティーワイ．リミティッド	抗炎症作用のある化合物および組成物
DE3864188D1 (de) *	1987-05-20	1991-09-19	Ueno Seiyaku Oyo Kenkyujo Kk	Kondom.
JP2756131B2 (ja) *	1987-07-01	1998-05-25	ジェネンテク，インコーポレイテッド	フィブリンの沈着または癒着の予防のための方法および治療学的組成物
US5055298A (en) *	1987-12-01	1991-10-08	Chemisches Laboratorium Dr. Kurt Richter Gmbh	Cosmetic composition comprising an extracellular connective tissue matrix
JPH01213227A (ja) *	1988-02-23	1989-08-28	Tadashi Koyake	軟膏剤及び液剤
IT1219587B (it) *	1988-05-13	1990-05-18	Fidia Farmaceutici	Polisaccaridi carbossiilici autoreticolati
US4981955A (en) *	1988-06-28	1991-01-01	Lopez Lorenzo L	Depolymerization method of heparin
JPH0232013A (ja) *	1988-07-20	1990-02-01	Denki Kagaku Kogyo Kk	点鼻剤
JPH02200624A (ja) *	1989-01-30	1990-08-08	Nippon Kayaku Co Ltd	歯科用包帯剤
HU203372B (en) *	1989-02-24	1991-07-29	Richter Gedeon Vegyeszet	Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
US5472950A (en) *	1989-02-24	1995-12-05	Richter Gedeon Vegyeszeti Gyar Rt.	Compositions containing cobalt hyaluronic acid complex
US6458774B1 (en) *	1989-02-24	2002-10-01	Richter Gedeon Vegyeszeti Gyar Rt.	Compositions containing hyaluronic acid associates and a process for preparing same
CA1340994C (en) *	1989-09-21	2000-05-16	Rudolf Edgar Dr. Falk	Treatment of conditions and disease
JP2945993B2 (ja) *	1989-12-05	1999-09-06	武田薬品工業株式会社	外用剤
US5141928B1 (en) *	1989-12-20	1995-11-14	Brujo Inc	Ophthalmic medication
NL8903155A (nl) *	1989-12-23	1991-07-16	Stamicarbon	Harssamenstelling op basis van een polyesterhars, een aminohars en een epoxyhars.
WO1991011992A1 (en) *	1990-02-13	1991-08-22	Zerega Gere S Di	Peritoneal induced medicaments
IT1240316B (it) *	1990-02-21	1993-12-07	Ricerca Di Schiena Del Dr. Michele G. Di Schiema & C.	Composizioni a base di acido ialuronico ad alto peso molecolare somministrabili per via topica per il trattamento di infiammazioni del cavo orale ,per la cosmetica e l'igiene del cavo orale
US5910489A (en) *	1990-09-18	1999-06-08	Hyal Pharmaceutical Corporation	Topical composition containing hyaluronic acid and NSAIDS
US5639738A (en) *	1992-02-20	1997-06-17	Hyal Pharmaceutical Corporation	Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
US5990096A (en) *	1990-09-18	1999-11-23	Hyal Pharmaceutical Corporation	Formulations containing hyaluronic acid
CA2061703C (en) *	1992-02-20	2002-07-02	Rudolf E. Falk	Formulations containing hyaluronic acid
CA2061566C (en) *	1992-02-20	2002-07-09	Rudolf E. Falk	Treatment of disease employing hyaluronic acid and nsaids
US5824658A (en) *	1990-09-18	1998-10-20	Hyal Pharmaceutical Corporation	Topical composition containing hyaluronic acid and NSAIDS
IT1243435B (it) *	1990-10-05	1994-06-10	Altergon Sa	Composizioni farmaceutiche per uso topico comprendenti acido ialuronico sale sodico e sostanze disinfettanti
US5492936A (en) *	1990-11-30	1996-02-20	Allergan, Inc.	Bimodal molecular weight hyaluronate formulations and methods for using same
US5234914A (en) *	1991-06-11	1993-08-10	Patent Biopharmaceutics, Inc.	Methods of treating hemorrhoids and anorecial disease
US5977088A (en) *	1991-07-03	1999-11-02	Hyal Pharmaceutical Corporation	Formulations containing hyaluronic acid
US6103704A (en) *	1991-07-03	2000-08-15	Hyal Pharmaceutical Corporation	Therapeutic methods using hyaluronic acid
US5834444A (en) *	1991-07-03	1998-11-10	Hyal Pharmaceutical Corporation	Hyaluronic acid and salts thereof inhibit arterial restenosis
US6022866A (en) *	1991-07-03	2000-02-08	Hyal Pharmaceutical Corporation	Use of hyaluronic acid and forms to prevent arterial restenosis
US5792753A (en) *	1991-07-03	1998-08-11	Hyal Pharmaceutical Corporation	Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US5817644A (en) *	1991-07-03	1998-10-06	Hyal Pharmaceutical Corporation	Targeting of dosages of medicine and therapeutic agents
US5990095A (en) *	1991-07-03	1999-11-23	Hyal Pharmaceutical Corporation	Use of hyaluronic acid and forms to prevent arterial restenosis
WO1994007505A1 (en) *	1991-07-03	1994-04-14	Norpharmco Inc.	Use of hyaluronic acid and forms to prevent arterial restenosis
DE69333005T2 (de) *	1992-02-10	2004-04-01	Advanced Medical Optics, Inc., Santa Ana	Zusammensetzungen von hyaluronat mit bimodalem molekulargewicht und verfahren zu deren verwendung
US6136793A (en) *	1992-02-20	2000-10-24	Hyal Pharmaceutical Corporation	Formulations containing hyaluronic acid
CA2061567C (en) *	1992-02-20	1998-02-03	Rudolf E. Falk	Use of hyaluronic acid to repair ischemia reperfusion damage
US6218373B1 (en)	1992-02-20	2001-04-17	Hyal Pharmaceutical Corporation	Formulations containing hyaluronic acid
US5767106A (en) *	1992-02-21	1998-06-16	Hyal Pharmaceutical Corporation	Treatment of disease and conditions associated with macrophage infiltration
CA2130762C (en) *	1994-08-24	1999-07-06	Eva Anne Turley	Treatment of disease and conditions associated with macrophage infiltration
US6114314A (en) *	1992-02-21	2000-09-05	Hyal Pharmaceutical Corp.	Formulations containing hyaluronic acid
ES2079994B1 (es) *	1992-10-07	1996-08-01	Cusi Lab	Formulacion farmaceutica a base de polimixina-trimetoprim y un agente antiinflamatorio para su utilizacion topica oftalmica y otica.
IT1263144B (it) *	1993-02-04	1996-08-01	Lanfranco Callegaro	Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive
AU5643994A (en) *	1993-03-04	1994-09-08	Genzyme Limited	Controlled molecular weight reduction of polymers
US5616568A (en) *	1993-11-30	1997-04-01	The Research Foundation Of State University Of New York	Functionalized derivatives of hyaluronic acid
JP4010574B2 (ja) *	1994-12-05	2007-11-21	電気化学工業株式会社	皮膚外用剤
US5972326A (en) *	1995-04-18	1999-10-26	Galin; Miles A.	Controlled release of pharmaceuticals in the anterior chamber of the eye
CA2154103C (en) *	1995-07-18	1998-02-24	Samuel Simon Asculai	Treatment of mucous membrane disease, trauma or condition and for the relief of pain
ZA966579B (en) *	1995-08-04	1998-02-02	Wakamoto Pharma Co Ltd	O/W emulsion composition for eye drops.
IT1287227B1 (it) *	1996-04-04	1998-08-04	Fidia Spa In Amministrazione S	Acido ialuronico quale componente del liquido di conservazione della cornea
US5939047A (en) *	1996-04-16	1999-08-17	Jernberg; Gary R.	Local delivery of chemotherapeutic agents for treatment of periodontal disease
US6451326B2 (en)	1996-05-02	2002-09-17	Burt D. Ensley	Cosmetic compositions
HU225991B1 (en) *	1997-04-29	2008-02-28	Richter Gedeon Nyrt	Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer
IT1287967B1 (it) *	1996-10-17	1998-09-10	Fidia Spa In Amministrazione S	Preparazioni farmaceutiche per uso anestetico locale
US5843186A (en) *	1996-12-20	1998-12-01	Implemed, Inc.	Intraocular lens with antimicrobial activity
US20050090662A1 (en) *	1997-01-15	2005-04-28	Beavers Ellington M.	Method of making free acids from polysaccharide salts
US5789571A (en) *	1997-01-15	1998-08-04	Biocoat Incorporated	Method of making free acids from polysaccharide salts
US6294170B1 (en)	1997-08-08	2001-09-25	Amgen Inc.	Composition and method for treating inflammatory diseases
WO1998045335A1 (en) *	1997-04-04	1998-10-15	Fidia Advanced Biopolymers, S.R.L.	N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation
US6123957A (en) *	1997-07-16	2000-09-26	Jernberg; Gary R.	Delivery of agents and method for regeneration of periodontal tissues
CA2300049C (en)	1997-08-08	2009-03-10	Duke University	Compositions, apparatus and methods for facilitating surgical procedures
US6711436B1 (en)	1997-08-08	2004-03-23	Duke University	Compositions, apparatus and methods for facilitating surgical procedures
US6197785B1 (en)	1997-09-03	2001-03-06	Guilford Pharmaceuticals Inc.	Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6514983B1 (en)	1997-09-03	2003-02-04	Guilford Pharmaceuticals Inc.	Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6346536B1 (en)	1997-09-03	2002-02-12	Guilford Pharmaceuticals Inc.	Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6291425B1 (en)	1999-09-01	2001-09-18	Guilford Pharmaceuticals Inc.	Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6426415B1 (en)	1997-09-03	2002-07-30	Guilford Pharmaceuticals Inc.	Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6635642B1 (en)	1997-09-03	2003-10-21	Guilford Pharmaceuticals Inc.	PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6391336B1 (en)	1997-09-22	2002-05-21	Royer Biomedical, Inc.	Inorganic-polymer complexes for the controlled release of compounds including medicinals
US6395749B1 (en)	1998-05-15	2002-05-28	Guilford Pharmaceuticals Inc.	Carboxamide compounds, methods, and compositions for inhibiting PARP activity
JP2002193830A (ja) *	1998-10-19	2002-07-10	High Chem Co Ltd	経鼻投与用医薬製剤
DK172900B1 (da) *	1998-12-18	1999-09-27	Per Julius Nielsen	Præparat samt kit til brug ved intraoculære operationer
US6387902B1 (en)	1998-12-31	2002-05-14	Guilford Pharmaceuticals, Inc.	Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
ATE376824T1 (de)	1999-01-13	2007-11-15	Alchemia Oncology Pty Ltd	Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
AU2745700A (en) *	1999-02-01	2000-08-18	Dermal Research Laboratories, Inc.	A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US6723733B2 (en)	2000-05-19	2004-04-20	Guilford Pharmaceuticals, Inc.	Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
WO2001091796A2 (en)	2000-06-01	2001-12-06	Guilford Pharmaceuticals Inc.	Methods, compounds and compositions for treating gout
US6726918B1 (en)	2000-07-05	2004-04-27	Oculex Pharmaceuticals, Inc.	Methods for treating inflammation-mediated conditions of the eye
AUPQ879500A0 (en) *	2000-07-14	2000-08-10	Meditech Research Limited	Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) *	2000-07-14	2015-06-30	Alchemia Oncology Pty Limited	Hyaluronan as a chemo-sensitizer in the treatment of cancer
US6828308B2 (en) *	2000-07-28	2004-12-07	Sinclair Pharmaceuticals, Ltd.	Compositions and methods for the treatment or prevention of inflammation
US7879824B2 (en) *	2001-07-31	2011-02-01	Dermal Research Laboratories, Inc.	Methods of preventing or treating diseases and conditions using complex carbohydrates
US6726898B2 (en)	2000-11-17	2004-04-27	Gary R. Jernberg	Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6576226B1 (en)	2000-11-17	2003-06-10	Gary R. Jernberg	Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
WO2002043785A2 (en)	2000-11-29	2002-06-06	Oculex Pharmaceuticals, Inc.	Intraocular implants for preventing transplant rejection in the eye
ITMI20010708A1 (it) *	2001-04-03	2002-10-03	Alessandro Randazzo	Trattamento farmacologico degli aloni notturni e delle immagini fantasma con parasimpaticomimetici diluiti aceclidina/pilocarpina dopo inter
AR034371A1 (es) *	2001-06-08	2004-02-18	Novartis Ag	Composiciones farmaceuticas
CN1578677A (zh) *	2001-08-27	2005-02-09	美迪泰克研究有限公司	改良的治疗方案
DE60218497T2 (de) *	2001-09-19	2007-11-08	Nycomed Gmbh	Kombination eines nsaids und eines pde-4 inhibitors
ITMI20021666A1 (it) *	2002-07-26	2004-01-26	Jasper Ltd Liability Co	Derivati dell'acido ialuronico
US20050048099A1 (en)	2003-01-09	2005-03-03	Allergan, Inc.	Ocular implant made by a double extrusion process
WO2005016386A1 (en) *	2003-08-19	2005-02-24	Meditech Research Limited	Improved therapeutic protocols
US20050043251A1 (en) *	2003-08-20	2005-02-24	Fairfield Clinical Trials, Llc	Method of treatment of otitis externa
US20050101582A1 (en)	2003-11-12	2005-05-12	Allergan, Inc.	Compositions and methods for treating a posterior segment of an eye
US20070224278A1 (en)	2003-11-12	2007-09-27	Lyons Robert T	Low immunogenicity corticosteroid compositions
US7625581B2 (en) *	2003-12-19	2009-12-01	Ethicon, Inc.	Tissue scaffolds for use in muscoloskeletal repairs
US20050147570A1 (en) *	2004-01-06	2005-07-07	Nordsiek Michael T.	Methods of administering diclofenac compositions for treating photodamaged skin, rosacea and/or acne
WO2005072701A1 (en)	2004-01-20	2005-08-11	Allergan, Inc.	Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
FR2865651B1 (fr)	2004-01-29	2007-09-28	Fabre Pierre Dermo Cosmetique	Compositions topiques associant des fragments de hyaluronate de sodium et un retinoide utiles en dermatologie cosmetique et medicale
US8119154B2 (en)	2004-04-30	2012-02-21	Allergan, Inc.	Sustained release intraocular implants and related methods
US20050244469A1 (en)	2004-04-30	2005-11-03	Allergan, Inc.	Extended therapeutic effect ocular implant treatments
US8147865B2 (en)	2004-04-30	2012-04-03	Allergan, Inc.	Steroid-containing sustained release intraocular implants and related methods
GB0416397D0 (en) *	2004-07-22	2004-08-25	Glaxo Group Ltd	Pharmaceutical formulations
EP1791523B1 (en) *	2004-09-21	2013-10-23	AMO Groningen B.V.	Method for the preparation of a viscoelastic solution
SE0402272D0 (sv)	2004-09-21	2004-09-21	Amo Groningen Bv	Methods of treating a body site with a viscoelastic preparation
EP1721602A1 (en) *	2005-05-11	2006-11-15	The Jordanian Pharmaceutical Manufacturing Co.	Controlled release oral drug delivery system
FR2888752B1 (fr) *	2005-07-22	2007-10-05	Fabre Pierre Dermo Cosmetique	Complexe d'association intermoleculaire d'un transporteur et d'un principe actif
JP5465431B2 (ja) *	2005-07-27	2014-04-09	アルケミアオンコロジーピーティーワイリミテッド	ヒアルロナンを用いる治療プロトコル
BRPI0615619A2 (pt) *	2005-09-07	2011-05-24	Alchemia Oncology Pty Ltd	composições terapêuticas que compreendem hialuronana e anticorpos terapêuticos bem como métodos de tratamento
US20070065515A1 (en) *	2005-09-22	2007-03-22	Key Douglas J	Methods and compositions for treating skin lines and wrinkles and improving skin quality
JP4555232B2 (ja) *	2006-01-25	2010-09-29	Ｈｏｙａ株式会社	組織の蛍光染色方法
US8668676B2 (en)	2006-06-19	2014-03-11	Allergan, Inc.	Apparatus and methods for implanting particulate ocular implants
US8802128B2 (en)	2006-06-23	2014-08-12	Allergan, Inc.	Steroid-containing sustained release intraocular implants and related methods
CA2654255A1 (en) *	2006-06-28	2008-01-03	Novozymes Biopolymer A/S	Compositions with several hyaluronic acid fractions for cosmetic and medical uses
WO2008003321A2 (en) *	2006-07-07	2008-01-10	Novozymes Biopolymer A/S	Compositions with several hyaluronic acid fractions for cosmetic use
US9039761B2 (en)	2006-08-04	2015-05-26	Allergan, Inc.	Ocular implant delivery assemblies with distal caps
AU2007295894B2 (en)	2006-09-13	2013-10-17	Enhance Skin Products, Inc.	Cosmetic composition for the treatment of skin and methods thereof
US8466128B2 (en) *	2007-01-30	2013-06-18	Cypress Pharmaceuticals, Inc.	Hyaluronate compositions
US20090068122A1 (en) *	2007-09-06	2009-03-12	Shira Pilch	Dentifrice Compositions for Treating Xerostomia
CN101896204B (zh)	2007-11-16	2015-05-20	爱力根有限公司	用于治疗紫癜的组合物及方法
EP2288355A1 (en) *	2008-05-30	2011-03-02	Fairfield Clinical Trials LLC	Method and composition for skin inflammation and discoloration
WO2010003797A1 (en) *	2008-07-09	2010-01-14	Novozymes Biopharma Dk A/S	Hyaluronic acid for corneal wound healing
KR101789337B1 (ko)	2008-10-02	2017-10-23	엘.알.알.앤드 디 리미티드	계면층 상처 드레싱
CN101385874B (zh) *	2008-10-23	2012-11-28	武汉大学	一种含有高分子透明质酸的生物滑液的制备方法
US8545554B2 (en)	2009-01-16	2013-10-01	Allergan, Inc.	Intraocular injector
AU2010247814B2 (en) *	2009-05-11	2015-08-13	Celsus Therapeutics Plc	Lipid-polymer conjugates, their preparation and uses thereof
TWI516269B (zh)	2009-08-14	2016-01-11	禾伸堂生技股份有限公司	使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物
TWI383796B (zh)	2009-08-14	2013-02-01	Holy Stone Healthcare Co Ltd	Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer
US8575130B2 (en)	2010-01-04	2013-11-05	Holy Stone Healthcare Co., Ltd.	Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease
US8722644B2 (en)	2010-01-04	2014-05-13	Holy Stone Healthcare Co., Ltd.	Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer
US9114188B2 (en)	2010-01-13	2015-08-25	Allergan, Industrie, S.A.S.	Stable hydrogel compositions including additives
US20110172180A1 (en)	2010-01-13	2011-07-14	Allergan Industrie. Sas	Heat stable hyaluronic acid compositions for dermatological use
US9029347B2 (en)	2010-08-05	2015-05-12	Holy Stone Healthcare Co., Ltd.	Method and mixture for treating and preventing inflammatory bowel disease
IT1407283B1 (it) *	2010-12-06	2014-04-04	Paoli Ambrosi De	Nuovo composto di carnosina
CZ303548B6 (cs)	2011-01-05	2012-11-28	Contipro Pharma A.S.	Zdravotní prípravek tvorící jód, zpusob jeho prípravy a bandáž, která jej obsahuje
CZ22394U1 (cs)	2011-03-11	2011-06-20	Contipro C, A.S.	Antimikrobiální smes a kryt pro podporu hojení ran s antimikrobiálním úcinkem
HUE037474T2 (hu)	2011-07-07	2018-08-28	Holy Stone Healthcare Co Ltd	Készítmény gyulladással kapcsolatban rendellenesség kezelésében és megelõzésében történõ alkalmazásra
ES2665254T3 (es)	2011-07-12	2018-04-25	Holy Stone Healthcare Co., Ltd.	Composiciones que comprenden ácido hialurónico para tratamiento y prevención de enfermedades relacionadas con las mucosas
ITMI20111747A1 (it)	2011-09-28	2013-03-29	Fidia Farmaceutici	Composizioni farmaceutiche topiche comprendenti aciclovir
ITPD20120173A1 (it)	2012-05-31	2013-12-01	Fidia Farmaceutici	"nuovo sistema di rilascio di proteine idrofobiche"
JP2014141475A (ja) *	2012-12-27	2014-08-07	Daiichi Sankyo Co Ltd	新規美白剤
KR101412776B1 (ko)	2013-03-11	2014-07-01	가톨릭대학교 산학협력단	각결막염 치료용 점안제 조성물 및 이의 제조 방법
CN103319627A (zh) *	2013-07-10	2013-09-25	南宁中诺生物工程有限责任公司	一种对透明质酸钠进行分子量分级的方法
US9089562B2 (en) *	2013-08-28	2015-07-28	Presbyopia Therapies Llc	Compositions and methods for the treatment of presbyopia
WO2015122853A1 (en) *	2014-02-11	2015-08-20	Vid D.O.O.	Pharmacological ophthalmic composition for use in the correction of presbyopia and its administration
EP2910255A1 (en) *	2014-02-19	2015-08-26	MedSkin Solutions Dr. Suwelack AG	Methods for the production of biopolymers with defined average molecular weight
US9603867B2 (en) *	2015-03-03	2017-03-28	Yung Shin Pharm. Ind. Co., Ltd.	Pharmaceutical composition for improving wound healing or prophylactically preventing or inhibiting scar formation
ITUB20152542A1 (it) *	2015-07-28	2017-01-28	Altergon Sa	Formulati oftalmici a base di complessi cooperativi di acido ialuronico a basso e alto peso molecolare
EP3415586B1 (en)	2016-02-12	2022-11-30	Laimu Corporation	Wound treatment agent and method for producing same
US9867810B1 (en)	2016-08-19	2018-01-16	Orasis Pharmaceuticals Ltd.	Ophthalmic pharmaceutical compositions and uses relating thereto
CN106727246A (zh) *	2017-02-08	2017-05-31	上海元茵生物科技有限公司	小牛血清细胞营养液
CN107802597B (zh) *	2017-12-08	2020-07-31	北京诺康达医药科技股份有限公司	一种玻璃酸钠组合物及其制备方法和应用
MX2020007692A (es) *	2018-01-18	2020-09-14	Faes Farma Sa	Composiciones oftalmicas que comprenden bilastina, una beta-ciclodextrina y al menos un agente de gelificacion.
FR3086865B1 (fr) *	2018-10-04	2023-04-28	Matthieu Leconte	Preparation ophtalmique et lentille d'orthokeratologie pour l'inhibition, la prevention et/ou la limitation de la progression de la myopie
US20210251970A1 (en)	2018-10-10	2021-08-19	Presbyopia Therapies Inc	Compositions and methods for storage stable ophthalmic drugs
US12180206B2 (en)	2021-11-17	2024-12-31	Lenz Therapeutics Operations, Inc.	Aceclidine derivatives, compositions thereof and methods of use thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2583096A (en) *	1949-01-15	1952-01-22	Searle & Co	Process for the production of high viscosity hyaluronic acid
DE1047380B (de) *	1954-08-18	1958-12-24	American Home Prod	Verfahren zur Herstellung einer hyaluronidasefreien, teilweise depolymerisierte Hyaluronsaeure enthaltenden waessrigen Traegerloesung fuer Arzneimittel
GB818336A (en) *	1956-06-22	1959-08-12	Erba Carlo Spa	A new acid aminopolysaccharide and a process for the production thereof
FR1425265A (fr) *	1962-05-14	1966-01-24	Parke Davis & Co	Procédé de préparation d'un nouveau polysaccharide et de ses sels
FR3715M (fr) *	1964-06-11	1965-11-29	Lucien Nouvel	Antithermiques et antirhumatismaux améliorés.
US3887703A (en) *	1967-03-24	1975-06-03	Oreal	Mucopolysaccharides, their preparation and use in cosmetic and pharmaceutical compositions
US3792164A (en) *	1970-03-31	1974-02-12	Chemway Corp	Ophthalmic composition comprising water-soluble alkaloid salts of polyuronic acids
GB1283892A (en) *	1970-06-08	1972-08-02	Irwin Irville Lubowe	Improvements in and relating to medicinal compositions for application to the skin and/or hair
DE2364373A1 (de) *	1973-12-22	1975-07-10	Hahn Carl Dr Gmbh	Pharmazeutische und kosmetische praeparate zur aeusserlichen anwendung
US3936081A (en) *	1974-02-27	1976-02-03	R & G Sloane Manufacturing Co., Inc.	Pipe joint and method of making same
US4141973A (en) *	1975-10-17	1979-02-27	Biotrics, Inc.	Ultrapure hyaluronic acid and the use thereof
HU172937B (hu) *	1975-12-18	1979-01-28	Chinoin Gyogyszer Es Vegyeszet	Sposob poluchenija novykh proizvodnykh khondroitin-sernoj kisloty s mestno anestezirujuhhim ehffektom
SE7901565L (sv) *	1979-02-21	1980-08-22	Pharmacia Ab	Medel for immunisering
JPS55153711A (en) *	1979-05-19	1980-11-29	Pola Chem Ind Inc	Cosmetic lotion
HU185926B (en) *	1979-09-27	1985-04-28	Agostne Kahan	Process for preparing water soluble derivatives of non-steroid antiinflammatory compositions and pharmaceutical compositins containing such derivatives
US4272522A (en) *	1979-10-15	1981-06-09	Balazs Endre A	Method for stimulating phagocytic activity and synergistic compositions therefor
US4303676A (en) *	1980-03-21	1981-12-01	Balazs Endre A	Hyaluronate based compositions and cosmetic formulations containing same
JPS5885813A (ja) *	1981-11-17	1983-05-23	Toyo Jozo Co Ltd	吸収性良好な製剤
JPS57183707A (en) *	1981-05-02	1982-11-12	Shiseido Co Ltd	Cosmetic
US4359458A (en) *	1981-09-28	1982-11-16	American Cyanamid Company	O-β. -D (and O-α.. -D) Multigalactopyranosyl, xylopyranosyl and glucopyranosyl sulfate salts
JPS591405A (ja) *	1982-06-28	1984-01-06	Shiseido Co Ltd	乳化組成物
JPS597106A (ja) *	1982-07-06	1984-01-14	Shiseido Co Ltd	乳化組成物
JPS5920212A (ja) *	1982-07-27	1984-02-01	Shiseido Co Ltd	乳化組成物
JPS5939338A (ja) *	1982-08-30	1984-03-03	Shiseido Co Ltd	乳化組成物
IT1212892B (it) *	1983-10-11	1989-11-30	Della Valle Francesco	Acido ialuronico ottenuto per mezzodi filtrazione molecolare sprovvisto di attivita' infiammatoria e sua utilizzazione terapeutica
JPS59219209A (ja) *	1983-05-28	1984-12-10	Kanebo Ltd	皮膚化粧料
AU555747B2 (en) *	1983-08-09	1986-10-09	Cilco Inc.	Chondroitin sulfate and sodium hyaluronate composition
DE3461292D1 (en) *	1983-08-12	1987-01-02	Ciba Geigy Ag	Monoclinic lead chromate pigments
DE3334595A1 (de) *	1983-09-24	1985-04-18	B. Braun Melsungen Ag, 3508 Melsungen	Wirkstoffdepot
DE3482812D1 (de) *	1983-10-11	1990-08-30	Fidia Spa	Fraktionen von hyaluronsaeure mit pharmazeutischer aktivitaet, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
JPS61180723A (ja) *	1985-02-06	1986-08-13	Sanwa Kagaku Kenkyusho:Kk	易吸収性カリジノゲナ−ゼ製剤用組成物
US5095037B1 (en) *	1989-12-21	1995-12-19	Nissho Kk	Combined anti-inflammatory agent
WO1991011992A1 (en) *	1990-02-13	1991-08-22	Zerega Gere S Di	Peritoneal induced medicaments

1985
- 1985-04-05 IT IT8547924A patent/IT1229075B/it active
- 1985-04-09 CN CN85102921A patent/CN85102921B/zh not_active Expired
1986
- 1986-03-25 IL IL78263A patent/IL78263A0/xx active IP Right Review Request
- 1986-03-27 IN IN248/CAL/86A patent/IN165867B/en unknown
- 1986-03-27 IE IE84786A patent/IE64440B1/en not_active IP Right Cessation
- 1986-03-27 AT AT86302291T patent/ATE98495T1/de not_active IP Right Cessation
- 1986-03-27 EP EP19930200175 patent/EP0555898A3/en not_active Withdrawn
- 1986-03-27 EP EP86302291A patent/EP0197718B2/en not_active Expired - Lifetime
- 1986-03-27 DE DE3689384T patent/DE3689384T3/de not_active Expired - Lifetime
- 1986-03-31 PH PH33597A patent/PH29979A/en unknown
- 1986-04-01 FR FR868604601A patent/FR2579895B1/fr not_active Expired - Lifetime
- 1986-04-01 FI FI861395A patent/FI83966C/fi not_active IP Right Cessation
- 1986-04-02 DK DK149886A patent/DK149886A/da not_active Application Discontinuation
- 1986-04-03 LU LU86386A patent/LU86386A1/fr unknown
- 1986-04-03 HU HU861402A patent/HU204202B/hu unknown
- 1986-04-03 AR AR86303552A patent/AR245369A1/es active
- 1986-04-03 US US06/847,632 patent/US4736024A/en not_active Expired - Lifetime
- 1986-04-03 BE BE1/011467A patent/BE904547A/fr not_active IP Right Cessation
- 1986-04-03 ZA ZA862463A patent/ZA862463B/xx unknown
- 1986-04-04 AU AU55662/86A patent/AU592077B2/en not_active Expired
- 1986-04-04 ES ES553714A patent/ES8800055A1/es not_active Expired
- 1986-04-04 KR KR1019860002595A patent/KR910006810B1/ko not_active IP Right Cessation
- 1986-04-04 CH CH1340/86A patent/CH672886A5/fr not_active IP Right Cessation
- 1986-04-04 CA CA000505909A patent/CA1340825C/en not_active Expired - Lifetime
- 1986-04-04 CA CA000617112A patent/CA1341418C/en not_active Expired - Lifetime
- 1986-04-04 NO NO861331A patent/NO174277C/no unknown
- 1986-04-04 PT PT82342A patent/PT82342B/pt unknown
- 1986-04-04 JP JP61079060A patent/JP2585216B2/ja not_active Expired - Lifetime
1988
- 1988-04-02 NZ NZ215676A patent/NZ215676A/xx unknown
1996
- 1996-06-12 JP JP8151346A patent/JP2677778B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU592077B2 (en)	1990-01-04
EP0197718B2 (en)	2001-07-25
DK149886A (da)	1986-10-06
CA1341418C (en)	2003-01-21
HUT40579A (en)	1987-01-28
FI83966C (fi)	1991-09-25
DE3689384T3 (de)	2003-05-15
ZA862463B (en)	1987-12-30
AR245369A1 (es)	1994-01-31
IN165867B (it)	1990-02-03
IL78263A0 (en)	1986-07-31
KR860008202A (ko)	1986-11-12
PH29979A (en)	1996-10-29
IE64440B1 (en)	1995-08-09
NZ215676A (en)	1989-08-29
BE904547A (fr)	1986-10-03
CA1340825C (en)	1999-11-23
HU204202B (en)	1991-12-30
US4736024A (en)	1988-04-05
DE3689384D1 (de)	1994-01-27
JPS61236732A (ja)	1986-10-22
JP2585216B2 (ja)	1997-02-26
LU86386A1 (fr)	1986-09-02
NO174277B (no)	1994-01-03
CN85102921B (zh)	1988-06-08
DE3689384T2 (de)	1994-07-07
FI861395A (fi)	1986-10-06
AU5566286A (en)	1986-10-16
ES553714A0 (es)	1987-11-16
EP0555898A2 (en)	1993-08-18
CH672886A5 (it)	1990-01-15
EP0555898A3 (en)	1993-10-20
DK149886D0 (da)	1986-04-02
NO861331L (no)	1986-10-06
JPH09169667A (ja)	1997-06-30
KR910006810B1 (ko)	1991-09-02
PT82342B (pt)	1988-03-03
NO174277C (no)	1994-04-13
CN85102921A (zh)	1986-10-08
EP0197718A3 (en)	1987-09-09
IT8547924A0 (it)	1985-04-05
PT82342A (en)	1986-05-01
ATE98495T1 (de)	1994-01-15
FR2579895B1 (it)	1990-11-23
EP0197718B1 (en)	1993-12-15
FR2579895A1 (it)	1986-10-10
JP2677778B2 (ja)	1997-11-17
FI861395A0 (fi)	1986-04-01
EP0197718A2 (en)	1986-10-15
FI83966B (fi)	1991-06-14
ES8800055A1 (es)	1987-11-16
IE860847L (en)	1986-10-05

Publication	Publication Date	Title
IT1229075B (it)	1991-07-17	Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
HUT74270A (en)	1996-11-28	Aqueous pharmaceutical preparations of g-csf with a long shelf life and process to prepare them
EP0259485A4 (en)	1988-07-29	HEAVY METAL SALTS OF HYALURONIC ACID FOR USE AS AN ANTIMICROBIAL AGENT.
RU93047799A (ru)	1996-03-20	Композиции, содержащие ретиноевые кислоты и токоферол
ES8603271A1 (es)	1985-12-16	Un metodo de producir una composicion de interleuquina-2
ES2005852A6 (es)	1989-04-01	Metodo para fabricar composiciones farmaceuticas a base de oligosacaridos sulfatados sinteticos.
NZ233102A (en)	1991-08-27	Aqueous ibuprofen compositions containing suspension stabilisers, taste masking ingredients and buffer acids to give a ph between 1.5 and 3.5
DE3271532D1 (en)	1986-07-10	Salts of n-substituted-2-pyrrolidone-4-carboxylic acids as humectants
ES2026133T3 (es)	1992-04-16	Una composicion detergente granular.
ZA856905B (en)	1986-06-25	Expectorant
MY101750A (en)	1992-01-17	Improvements in or relating to calcium salts.
ES8307491A1 (es)	1983-07-01	Un metodo para preparar una composicion de gel acuoso semi- solido para alimentacion de heridos
MY103079A (en)	1993-04-30	New ophtalmological composition of matter
IL78431A0 (en)	1986-08-31	Substituted 2,3,4,9-tetrahydro-1h-carbazole-1-acetic acid and salts thereof,their production and pharmaceutical compositions containing them
ES8608542A1 (es)	1986-06-16	Un metodo para producir una composicion de gamma-interferon de ser humano.
IT1184675B (it)	1987-10-28	Procedimento per la preparazione di sali dell'acido ialuronico
ES2009569A6 (es)	1989-10-01	Procedimiento de preparacion de una composicion farmaceutica a base de algas que contengan selenio que actua sobre el corazon y el sistema cardiovascular.
AU3232784A (en)	1985-02-28	Compositions containing s-adenosyl-l methionine
AU554891B1 (en)	1986-09-04	Painkilling composition comprising calcium gluconate, pantothenic acid, vitamins b6 and c and magnesium hydroxide
IE34386L (en)	1971-02-07	Acetylsalicylic acid-containing composition
ES2010559A6 (es)	1989-11-16	Procedimiento de preparacion de composiciones farmaceuticas antivirales de aplicacion externa que se acumulan en la piel.
GB1437010A (en)	1976-05-26	Structural unit
JPS5448711A (en)	1979-04-17	Racemization of optical active nnacyllamino acid in the atate of aqueous solution
CA710830A (en)	1965-06-01	Disodium and calcium salt of the calcium complex of 2-aminocyclohexyl 2'-aminoethyl ether-n,n,n',n'-tetraacetic acid
IT1260996B (it)	1996-04-29	Fiala a soluzione per infusione di acido tiottico in forma di sale idrosolubile dell'acido tiottico.

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19990210