CN101786961A - Chromium threonine, preparation method and application thereof - Google Patents
Chromium threonine, preparation method and application thereof Download PDFInfo
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- CN101786961A CN101786961A CN201010108148A CN201010108148A CN101786961A CN 101786961 A CN101786961 A CN 101786961A CN 201010108148 A CN201010108148 A CN 201010108148A CN 201010108148 A CN201010108148 A CN 201010108148A CN 101786961 A CN101786961 A CN 101786961A
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- chromium
- threonine
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- 239000011651 chromium Substances 0.000 title claims abstract description 96
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 title claims abstract description 93
- 229910052804 chromium Inorganic materials 0.000 title claims abstract description 87
- 239000004473 Threonine Substances 0.000 title claims abstract description 86
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 title claims abstract description 86
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 241001465754 Metazoa Species 0.000 claims abstract description 25
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 24
- 238000006243 chemical reaction Methods 0.000 claims abstract description 20
- 239000000047 product Substances 0.000 claims abstract description 19
- 238000001035 drying Methods 0.000 claims abstract description 10
- 239000011259 mixed solution Substances 0.000 claims abstract description 8
- 239000012065 filter cake Substances 0.000 claims abstract description 7
- 238000005406 washing Methods 0.000 claims abstract description 7
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 6
- 239000007864 aqueous solution Substances 0.000 claims abstract description 3
- 238000001816 cooling Methods 0.000 claims abstract description 3
- 239000000654 additive Substances 0.000 claims description 18
- 244000144977 poultry Species 0.000 claims description 12
- 238000000967 suction filtration Methods 0.000 claims description 12
- 230000000996 additive effect Effects 0.000 claims description 9
- 244000144987 brood Species 0.000 claims description 6
- PHFQLYPOURZARY-UHFFFAOYSA-N chromium trinitrate Chemical compound [Cr+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O PHFQLYPOURZARY-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 239000007858 starting material Substances 0.000 claims description 5
- QSWDMMVNRMROPK-UHFFFAOYSA-K chromium(3+) trichloride Chemical compound [Cl-].[Cl-].[Cl-].[Cr+3] QSWDMMVNRMROPK-UHFFFAOYSA-K 0.000 claims description 4
- 241000270666 Testudines Species 0.000 claims description 3
- GRWVQDDAKZFPFI-UHFFFAOYSA-H chromium(III) sulfate Chemical compound [Cr+3].[Cr+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRWVQDDAKZFPFI-UHFFFAOYSA-H 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- 229910021555 Chromium Chloride Inorganic materials 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 abstract description 6
- 239000011573 trace mineral Substances 0.000 abstract description 6
- 235000013619 trace mineral Nutrition 0.000 abstract description 6
- 239000013522 chelant Substances 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 2
- 238000005086 pumping Methods 0.000 abstract 2
- 235000019730 animal feed additive Nutrition 0.000 abstract 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 23
- 235000001014 amino acid Nutrition 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 10
- 235000013601 eggs Nutrition 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
- 206010013786 Dry skin Diseases 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229940046374 chromium picolinate Drugs 0.000 description 4
- GJYSUGXFENSLOO-UHFFFAOYSA-N chromium;pyridine-2-carboxylic acid Chemical compound [Cr].OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1 GJYSUGXFENSLOO-UHFFFAOYSA-N 0.000 description 4
- 230000001143 conditioned effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 244000144972 livestock Species 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 238000010792 warming Methods 0.000 description 4
- 241000287828 Gallus gallus Species 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000000050 nutritive effect Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000001850 reproductive effect Effects 0.000 description 3
- WSZOLRPXRPIUPK-WCCKRBBISA-N (2s)-2-amino-4-methylsulfanylbutanoic acid;chromium Chemical compound [Cr].CSCC[C@H](N)C(O)=O WSZOLRPXRPIUPK-WCCKRBBISA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 229910021556 Chromium(III) chloride Inorganic materials 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 230000002180 anti-stress Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229960000359 chromic chloride Drugs 0.000 description 2
- HPCCGRCEBFBZQP-UHFFFAOYSA-N chromium;pyridine-3-carboxylic acid Chemical compound [Cr].OC(=O)C1=CC=CN=C1 HPCCGRCEBFBZQP-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 229940029985 mineral supplement Drugs 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 229960004839 potassium iodide Drugs 0.000 description 2
- 235000007715 potassium iodide Nutrition 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- PODWXQQNRWNDGD-UHFFFAOYSA-L sodium thiosulfate pentahydrate Chemical compound O.O.O.O.O.[Na+].[Na+].[O-]S([S-])(=O)=O PODWXQQNRWNDGD-UHFFFAOYSA-L 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- QLOKJRIVRGCVIM-UHFFFAOYSA-N 1-[(4-methylsulfanylphenyl)methyl]piperazine Chemical compound C1=CC(SC)=CC=C1CN1CCNCC1 QLOKJRIVRGCVIM-UHFFFAOYSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 241001071864 Lethrinus laticaudis Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 239000006035 Tryptophane Substances 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- SJKRCWUQJZIWQB-UHFFFAOYSA-N azane;chromium Chemical compound N.[Cr] SJKRCWUQJZIWQB-UHFFFAOYSA-N 0.000 description 1
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 1
- 229960003644 aztreonam Drugs 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical class [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 description 1
- 229910001430 chromium ion Inorganic materials 0.000 description 1
- 229940117975 chromium trioxide Drugs 0.000 description 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N chromium trioxide Inorganic materials O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
- GAMDZJFZMJECOS-UHFFFAOYSA-N chromium(6+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Cr+6] GAMDZJFZMJECOS-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 235000021112 essential micronutrients Nutrition 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000006377 glucose transport Effects 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 238000003359 percent control normalization Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- KMUONIBRACKNSN-UHFFFAOYSA-N potassium dichromate Chemical compound [K+].[K+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O KMUONIBRACKNSN-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
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- 229960004799 tryptophan Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Landscapes
- Fodder In General (AREA)
Abstract
The invention belongs to feed additives and the field of preparation thereof and in particular discloses a threonine chelate named chromium threonine of which the molecular formula is Cr(C4H8NO3)3 and the molecular structural formula is represented below. The preparation method for the chromium threonine comprises the following steps: mixing trivalent inorganic chromium and aqueous solution of threonine, wherein the molar ratio of chromium element in the trivalent inorganic chromium to the threonine is (0.9-1.1):3, adding sodium hydroxide to control the pH value of the mixed solution to be between 6.5 and 7.5, controlling a reaction temperature to be between 60 and 100 DEG C and fully reacting the mixed solution to obtain a reaction product; and cooling, filtering and pumping the reaction product, adding ethanol into a filter cake, filtering the mixture, washing the mixture with the ethanol, and pumping and drying the mixture to obtain the finished product. The chromium threonine of the invention can be used as an animal feed additive, and can promote synchrotron absorption of the threonine and a trace element, namely the chromium, of animals, effectively promote growth of the animals, enhance immunity of the animals and increase utilization rate of the feed.
Description
Technical field
The present invention relates to a kind of fodder additives and preparation method thereof, relate in particular to a kind of amino acid chelate thing and its production and application.
Background technology
Threonine is a kind of important nutrition-fortifying agent, can play the nutritional fortification effect to cereal, cake, milk-product etc.Threonine is the same with tryptophane, also has to recover human-body fatigue, promote the function of growing.Pharmaceutically,, human body skin is had the water holding effect, after oligonucleotide chain combines, can play an important role the protection cytolemma owing to contain hydroxyl in the structure of Threonine; Threonine can also promote the synthetic and Fatty Acid Oxidation of phosphatide in vivo, and its preparation has medicinal efficacies such as the human development of promotion, anti-fatty liveranti-fatty liver, is commonly used for a moiety in the aminoacids complex transfusion.Simultaneously, Threonine is still made efficient low microbiotic hypersensitive---the basic raw material of monobactam.Along with the raising of people's living standard and the continuous development of aquaculture, Threonine has been widely used in and has added pig starter feed, kind pig feed, broiler fodder, prawn feed and eel feed etc. as feed amino acid.Threonine has following characteristics as animal feedstuff additive: can adjust amino acid whose balance in the feed, promote growth of animal; Can improve meat; Can improve the nutritive value of the low animal-feed raw material of amino acid digestibility; Can be used for producing low proteic feed, help to save protein resource; Can reduce the animal-feed raw materials cost; Can reduce ammonia concentration and release rate in nitrogen content in feces of livestock and poultry and the urine, the livestock and poultry house.Threonine is as the common a kind of limiting amino acid of animal, and its content and proportioning directly affect the nutritive value of daily ration and the production performance of livestock and poultry, adds limiting amino acid and can improve efficiency of feed utilization to greatest extent in the animal daily ration.
Chromic salts is divided into inorganic chromium and organic chromium two big classes, and the branch of trivalent, sexavalence is arranged.Sexavalent chrome (Cr
6+) poisonous, with what the sexavalent chrome form existed chromium trioxide, potassiumchromate and potassium bichromate arranged; Inorganic trivalent chromium (Cr
3+) chromium trichloride etc. arranged; Organic trivalent chromium has chromium methionine, nicotinic acid chromium, yeast chromium, chromium picolinate etc.Wherein, inorganic chromium does not allow to add in feed.
Chromium (Cr
3+) be essential micronutrient element in the humans and animals body.Chromium can improve the bonding force of Regular Insulin and special acceptor, promotes the synthetic of glucose transport and liver glycogen; Regulate lipid metabolism, improve the blood fat situation; Keep nucleic acid construct integrity and stability, help the storages of amino acid in tissue such as glycine, Serine, methionine(Met), and strengthen proteic Synthesis; Enhancing body immunologic function and anti-stress ability, and can stimulate the hemopoietic function of body; Can improve the production performance of stressed animal, endocrine regulation.In addition, it all has good effect at aspects such as improving carcass quality and raising reproductive performance.
What use was more at present is chromium picolinate, nicotinic acid chromium, chromium methionine, yeast chromium etc., although wherein the chromium picolinate specific absorption is much higher than inorganic chromium, but after chromium picolinate enters in the animal body, chromium element and pyridine ring are combined closely, keeping original form for a long time, chromium ion is difficult to be utilized, and life-time service also can cause dna break, and mutagenesis is arranged.Simultaneously, pyridine ring also has certain detrimental effect to animal body, poisons liver; The effective constituent less stable of yeast chromium, bad quantification.
How better in conjunction with the advantage of above-mentioned nutritive ingredient and trace element, the complementarity of two kinds of materials can be found full expression in feed, and better promote the synchronous absorption of animal body to above-mentioned two kinds of materials, just become the technical problem that those skilled in the art need to be resolved hurrily.
Summary of the invention
The technical problem to be solved in the present invention is to overcome the deficiencies in the prior art, a kind of fodder additives chromium threonine that can promote that animal absorbs synchronously to Threonine and trace element chromium is provided, and provide the preparation method of a kind of technology chromium threonine simple, with low cost at this novel substance chromium threonine, also provide a kind of chromium threonine to be applied to method in the animal feedstuff additive simultaneously, to reach effective promotion growth of animal, strengthen the animal resistibility and to improve the purpose of food utilization efficiency.
For solving the problems of the technologies described above, the present invention proposes a kind of Threonine huge legendary turtle compound, it is characterized in that: the name of described Threonine huge legendary turtle compound is called chromium threonine (III), and its molecular formula is Cr (C
4H
8NO
3)
3, molecular structural formula is
Chromium threonine of the present invention is the light violet magenta powder, is slightly soluble in water, is insoluble to alcohols.As the important composition composition of glucose tolerance factor, the glucose normal level plays an important role with the trans-utilization that promotes body to sugar in the animal blood to keeping; Can impel Regular Insulin to activate and, quicken amino acid and enter in the cell and receptors bind, thereby promote protein synthesis, improve the fattening pig lean ratio, reduce fryer abdomen fat rate, improve carcass quality attached on the cell; Increase the avidity of tissue, regulate the secretion and the release of gonad-stimulating hormone, improve sow reproductive performance, increase sow ovulation and litter size Regular Insulin; Animal stress, be activated and promotion function of immune system aspect plays an important role to alleviating.
The present invention also provides a kind of preparation method of above-mentioned chromium threonine, may further comprise the steps:
(1) with trivalent inorganic chromium (the perhaps crystalline hydrate of inorganic chromium) and mass concentration is 10%～60% Threonine aqueous solution, the mol ratio of chromium element and Threonine is (0.9～1.1) in the described trivalent inorganic chromium: 3, the pH value of adding sodium hydroxide control mixed solution again is 6.5～7.5 (the general mass concentration of sodium hydroxide in reaction solution is 5%～45%), temperature of reaction is controlled at 60 ℃～100 ℃, fully obtains reaction product after the reaction;
(2) with described reaction product cooling, suction filtration, drain, in filter cake, add ethanol then, suction filtration again, at last with washing with alcohol, drain, obtain finished product after the drying.
Use the hydrogen peroxide oxidation trivalent chromium, add potassiumiodide again and be oxidized into iodine, the iodimetry,iodometry of Sulfothiorine titration iodine is surveyed trivalent chromium, measures threonine content with the method for deciding nitrogen; Can determine finally that by XRD and infrared spectra finished product is a chromium threonine.
Above-mentioned preparation method's main reaction formula is:
CrCl
3·6H
2O+3C
4H
9NO
3+3NaOH＝Cr(C
4H
8NO
3)
3+3NaCl+9H
2O。
Among the above-mentioned preparation method, described trivalent inorganic chromium preferably includes chromium chloride (CrCl
3), water miscible trivalent inorganic chromate salt such as chromium nitrate or chromium sulphate.
Among the above-mentioned preparation method, described exsiccant method is preferably and at room temperature is dried to earlier no ethanol smell, thorough drying under 80 ℃～150 ℃ temperature again.This preferred drying mode mainly is for security consideration, and the too high meeting of temperature makes product decompose.
The present invention also provides the application of above-mentioned chromium threonine in the preparation animal feedstuff additive.Described chromium threonine is preferred for preparing the fodder additives of pig feed, poultry feed, and described pig feed comprises brood sow feed, pig starter feed or grow-finish pig feed, and described poultry feed comprises poultry feed or egg fowl feed.
With the additive of above-mentioned chromium threonine as the brood sow feed, in feed per ton, add under the optimum condition of 150～250g, can obviously shorten the breeding cycle of sow, increase to produce and live young number and produce parity per year, reduce the equal death toll of nest.
With the additive of above-mentioned chromium threonine as pig starter feed, in feed per ton, add under the optimum condition of 150～200g, can improve the speed of growth of suckling piglet, strengthen its resistance against diseases.
With the additive of above-mentioned chromium threonine as the grow-finish pig feed, in feed per ton, add under the optimum condition of 100～250g, can improve day weight gain, the reduction material anharmonic ratio of fattening pig, help to improve the bodily form simultaneously, improve carcass quality, reduce the fat thickness degree, reduce fat ratio.
With the additive of above-mentioned chromium threonine as the poultry feed, in feed per ton, add under the condition of 100～250g, the speed of growth, reduction feedstuff-meat ratio, increase trunk protein, the reduction fat ratio of broiler chicken be can improve, and anti-stress ability, reduction mortality ratio improved.
With the additive of above-mentioned chromium threonine as egg fowl feed, in feed per ton, add under the situation of 150～300g, can improve the laying rate of laying hen, improve eggs ' quality, reduce cholesterol level in the yolk, Hough unit increases.
The addition manner of above-mentioned fodder additives preferably adds with solid form, will make other composition in the feed can the oxidation because of the moisture absorption because add with solid form.
Compared with prior art, the invention has the advantages that: chromium threonine of the present invention is to absorb by the amino acid approach in livestock and poultry alimentary tract, and its absorption rate is fast, and specific absorption improves greatly, the biological value height.Chromium threonine of the present invention also has good promoter action to the micro-element nutrition of improving animal.Chromium threonine of the present invention also can provide the nutrition of Threonine except that satisfying the needs of animal to trace element chromium, so can promote growth of animal, significantly improve the utilization ratio of feed.Chromium threonine of the present invention has stable chemical structure as trace mineral supplement, safety non-toxic, nonirritant, and the output of inorganic chromium is little in the animal excrement, therefore can protect environment, reduce and pollute.Trace mineral supplement chromium threonine of the present invention can be widely used in (as pig, fowl etc.) in the various animal-feeds, can significantly improve the growth performance of animal, improves the utilization ratio of feed.The preparation method who the present invention is directed to above-mentioned chromium threonine proposition also has advantages such as technology is simple, easy to operate, reaction is quick, equipment cost is cheap, energy-conserving and environment-protective.
Embodiment
Embodiment 1:
A kind of chromium threonine finished product of the present invention is to prepare by following steps: at first drop into 150g water in reactor, get the 35.8g Threonine then, put in the reaction vessel and fully stir, drop into the CrCl of 26.6g again
36H
2O, heating for dissolving also is warming up to 70 ℃, uses the pH value to 6.8 of 14g sodium hydroxide conditioned reaction mixed solution then, react 0.5h under the condition of normal pressure, postcooling to 30 ℃, suction filtration are finished in reaction, drain, filter cake after draining is placed the ethanol of 50ml, continue suction filtration, drain, use 95% washing with alcohol again, drain, prior to being dried to no ethanol smell under the room temperature,, prepare the finished product of light violet magenta after the pulverizing again 110 ℃ of following thorough dryings.
Finished product hydrogen peroxide oxidation trivalent chromium adds potassiumiodide again and is oxidized into iodine, and the iodimetry,iodometry of Sulfothiorine titration iodine is surveyed trivalent chromium, measures threonine content with the method for deciding nitrogen; According to measurement result, chromium content is 12.5% in the finished product, and threonine content is 85.5%, and moisture content is 1.5%, and surplus is an impurity.With XRD diffracting spectrum and infrared spectra can qualitative product be chromium threonine.
The above-mentioned fodder additives chromium threonine finished product that makes is used for the store pig feeding experiment.Select body weight 75kg, same cross combination, store pig 20 hurdles that body weight is close, every hurdle pig is weighed by head, with excessive pig, cross piggy, cad pig is chosen respectively, 6～12 of every circle pigs according to every group 5 hurdle, are divided into 4 groups at random, be every group of 5 repetitions, every hurdle is a repetition.Control group feed per ton adds chromium trichloride 250g, tests one group of feed per ton and adds chromium threonine 100g, tests two groups of feeds per ton and adds chromium threonine 175g, tests three groups of feeds per ton and adds chromium threonine 250g.Test-results sees Table 1.
Table 1: chromium threonine is to the influence of store pig production performance
| Group | Average initial weight kg | The heavy kg in average end | Average daily ingestion amount kg | Average daily gain g | Feedstuff-meat ratio |
| Control group | ??75.92±1.57 a | ??99.71±4.68 a | ??2.45±0.11 a | ??665.33±36.72 a | ??3.68±0.021 a |
| Test one group | ??76.03±1.32 a | ??101.67±3.07 b | ??2.48±0.15 a | ??710.11±41.26 b | ??3.49±0.034 b |
| Test two groups | ??75.42±1.49 a | ??103.48±4.17 b | ??2.52±0.09 a | ??728.83±23.26 b | ??3.46±0.019 b |
| Test three groups | ??76.10±1.63 a | ??105.54±3.89 b | ??2.51±0.12 a | ??732.56±39.74 b | ??3.43±0.082 b |
Annotate: same column shoulder marking-up parent phase expression difference together is remarkable (p＞0.05) not; The female expression significant difference (p＜0.05) inequality of same column shoulder marking-up.
As can be seen from Table 1, control group and test group be difference not significantly (p＞0.05) on average initial weight, average daily ingestion amount index, but the difference (p＜0.05) of significance is arranged on, average daily gain heavy at average end and the feedstuff-meat ratio; Along with the raising of chromium threonine addition, day weight gain has the trend of rising, feedstuff-meat ratio to have a declining tendency, but test group differences not significantly (p＞0.05).This test-results shows, chromium threonine has remarkable advantages improving the fattening pig speed of growth and improve on the price of deed.
Embodiment 2:
At first in reactor, drop into 300g water, get the 285g Threonine then, put in the reaction vessel and fully stir, drop into the Cr (NO of 325g again
3)
39H
2O, heating for dissolving also is warming up to 95 ℃, slowly drops into the pH value to 6.9 of the about 106g conditioned reaction of sodium hydroxide mixed solution then, react 2h under the condition of normal pressure, postcooling to 25 ℃, suction filtration are finished in reaction, drain, filter cake after draining is dropped in 95% ethanol of 180ml, stir the back of loosing and continue suction filtration, use 95% washing with alcohol again, drain, prior to being dried to no ethanol smell under the room temperature,, prepare the finished product of light violet magenta after the pulverizing again 95 ℃ of following thorough dryings.Adopt the detection method of embodiment 1 and means can record that chromium content is 12.6% in the finished product, threonine content is 85.0%, and moisture content is 1.9%, and surplus is an impurity.
The fodder additives that present embodiment is made makes an addition in the brood sow daily ration.Select the Du Luoke multiparity sow of same parity, be divided into four groups, 10 every group, breed with 2～3 Du Luoke boars for every group, require in a rutting sedson, to finish breeding.Wherein interpolation chromium nitrate 250g in the feed per ton of control group tests one group of feed per ton and adds chromium threonine 150g, two groups of feeds interpolation chromium threonine 175g per ton of test, three groups of feeds interpolation chromium threonine 250g per ton of test, and test-results sees Table 2.
Table 2: chromium threonine is to the influence of sow reproductive performance
Annotate: same column shoulder marking-up parent phase expression difference together is remarkable (p＞0.05) not; The female expression significant difference (p＜0.05) inequality of same column shoulder marking-up.
As can be seen from Table 2, for young number of nascent work and nascent litter weight, control group and test group difference is remarkable (p＞0.05) not; But along with the variation of feeding time, young number of the work of its 21 age in days and litter weight also change thereupon, and survival rate also shows the difference (p＜0.05) of significance; During 42 ages in days, the performance of the young number of living is similar to 21 ages in days, and incubation rate also reaches significant difference (p＜0.05).Above result shows: add the test group of chromium threonine, though not remarkable at the young number of the work of nascent brood sow and litter weight and control group difference, the survival rate in its later stage and incubation rate all reach significant difference, and litter weight also has raising trend.
Embodiment 3:
At first in reactor, drop into 35g water, get the 35.8g Threonine then, put in the reaction vessel and fully stir, drop into the Cr of 25g again
2(SO
4)
36H
2O, heating for dissolving also is warming up to 95 ℃, slowly drops into the pH value to 6.7 of the about 13.5g conditioned reaction of sodium hydroxide mixed solution then, react 2h under the condition of normal pressure, postcooling to 10 ℃, suction filtration are finished in reaction, drain, filter cake after draining is dropped in 95% ethanol of 20ml, stir the back of loosing and continue suction filtration, use 95% washing with alcohol again, drain, prior to being dried to no ethanol smell under the room temperature,, prepare the finished product of light violet magenta after the pulverizing again 95 ℃ of following thorough dryings.Adopt the detection method of embodiment 1 and means can record that chromium content is 12.6% in the finished product, threonine content is 84.9%, and moisture content is 1.7%, and surplus is an impurity.
The above-mentioned fodder additives that makes is used to the feeding experiment of feeding laying hen.Select 360 of the consistent blue commodity eggs in 39 seas in age in week of health, body weight for use, be divided into 4 groups at random, every group of 3 repetitions, each repeats 30.Test one group of interpolation ammonia chromium 150g of Soviet Union per ton, test two groups of interpolation chromium threonine 225g per ton, test three groups of chromium threonine 300g per ton; Control group interpolation chromium sulphate per ton 300g.Test-results sees Table 3.
Table 3: chromium threonine is to the influence of production performance of layer chicken
| Group | Laying rate % | Egg productivity g/ day/only | Food consumption g/ day/only | Feedstuff-egg ratio | Breakage rate % | Death rate % |
| Control group | ??81.27±1.62 a | ??48.69±0.98 a | ??94.92±1.34 a | ??1.95±0.03 a | ??0.50±0.09 a | ??1.32±0.35 a |
| Test one group | ??84.43±0.93 b | ??50.16±0.56 b | ??94.68±1.18 a | ??1.89±0.03 b | ??0.38±0.09 b | ??0.75±0.24 b |
| Test two groups | ??85.01±1.01 b | ??50.71±0.66 b | ??94.40±1.70 a | ??1.86±0.03 b | ??0.31±0.04 bc | ??0.66±0.25 b |
| Test three groups | ??85.76±1.10 b | ??51.44±0.06 b | ??94.59±0.94 a | ??1.84±0.05 b | ??0.28±0.04 c | ??0.35±0.20 c |
Annotate: same column shoulder marking-up parent phase expression difference together is remarkable (p＞0.05) not; The female expression significant difference (p＜0.05) inequality of same column shoulder marking-up.
As can be seen from Table 3, each test group is compared with control group on laying rate, egg productivity, feedstuff-egg ratio index and is improved, difference reaches conspicuous level (p＜0.05), the egg product matter of test group is better than control group, its breakage rate has been compared tangible minimizing with control group, difference reaches conspicuous level (p＜0.05); Test group is compared the death rate fall with control group all bigger, all significantly is lower than control group (p＜0.05); And the difference between the test group on indexs such as breakage rate, death rate has significance.Above test-results shows that chromium threonine can significantly improve the laying rate of laying hen and lay eggs heavily, can effectively improve feedstuff-egg ratio, reduce breakage rate and death rate, and not influence the daily ration palatability.
Embodiment 4:
At first in reactor, drop into 450Kg water, get the 335kg Threonine then, put in the reaction vessel and fully stir, drop into the CrCl of 233kg again
36H
2O, heating for dissolving also is warming up to 80 ℃, slowly drops into the pH value to 7.4 of the about 115kg conditioned reaction of sodium hydroxide mixed solution then, react 1h under the condition of normal pressure, postcooling to 20 ℃, suction filtration are finished in reaction, drain, filter cake after draining is dropped in the ethanol of 200L95%, stir the back of loosing and continue suction filtration, use 95% washing with alcohol again, drain, prior to being dried to no ethanol smell under the room temperature,, prepare the finished product of light violet magenta after the pulverizing again 95 ℃ of following thorough dryings.Adopt the detection method of embodiment 1 and means can record that chromium content is 11.8% in the finished product, threonine content is 86.5%, and moisture content is 1.3%, and surplus is an impurity.
Claims (7)
1. a name is called the Threonine huge legendary turtle compound of chromium threonine, and it is characterized in that: the molecular formula of described chromium threonine is Cr (C
4H
8NO
3)
3, molecular structural formula is as follows:
2. the preparation method of a chromium threonine as claimed in claim 1 may further comprise the steps:
(1) with trivalent inorganic chromium and mass concentration is 10%～60% Threonine aqueous solution, the mol ratio of chromium element and Threonine is (0.9～1.1) in the described trivalent inorganic chromium: 3, the pH value of adding sodium hydroxide control mixed solution again is 6.5～7.5, temperature of reaction is controlled at 60 ℃～100 ℃, fully obtains reaction product after the reaction;
(2) with described reaction product cooling, suction filtration, drain, in filter cake, add ethanol then, suction filtration again, at last with washing with alcohol, drain, obtain finished product after the drying.
3. preparation method according to claim 2 is characterized in that: described trivalent inorganic chromium comprises chromium chloride, chromium nitrate or chromium sulphate.
4. according to claim 2 or 3 described preparation methods, it is characterized in that: described exsiccant method is at room temperature being dried to earlier no ethanol smell, thorough drying under 80 ℃～150 ℃ temperature again.
One kind as claimed in claim 1 or as the application in the preparation animal feedstuff additive of each prepares in the claim 2～4 chromium threonine.
6. application according to claim 5 is characterized in that: described chromium threonine is the fodder additives that is used to prepare pig feed, and described pig feed comprises brood sow feed, pig starter feed or grow-finish pig feed; Wherein, brood sow feed per ton adds described chromium threonine 150～250g; Pig starter feed per ton adds described chromium threonine 150～200g; Grow-finish pig feed per ton adds described chromium threonine 100～250g.
7. application according to claim 5 is characterized in that: described chromium threonine is the fodder additives that is used to prepare poultry feed, and described poultry feed comprises poultry feed or egg fowl feed; Wherein, poultry feed per ton adds described chromium threonine 100～250g; Egg fowl feed per ton adds described chromium threonine 150～300g.
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| CN115053937A (en) * | 2022-06-20 | 2022-09-16 | 浙江惠嘉生物科技股份有限公司 | Preparation method of chromium nicotinate nano dispersion preparation |
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| CN102550830B (en) * | 2012-02-17 | 2015-01-14 | 长沙兴嘉生物工程股份有限公司 | Method for applying and preparing gamma-aminobutyric acid complex compound |
| CN102718803A (en) * | 2012-06-01 | 2012-10-10 | 广州九益生物技术有限公司 | Preparation method and application of N-carbamoyl-L-chromium glutamate complex |
| CN103030584A (en) * | 2012-12-04 | 2013-04-10 | 山东省化工研究院 | Method for preparing feed additive tryptophan chromium complex |
| CN103739509A (en) * | 2014-01-09 | 2014-04-23 | 山东祥维斯生物科技有限公司 | Industrial production and preparation process of glycine chelated manganese |
| CN109362997A (en) * | 2018-10-15 | 2019-02-22 | 浙江省海洋水产研究所 | A kind of feed additive for improving the quality of mariculture fish and preparation method thereof |
| CN112209821A (en) * | 2020-11-05 | 2021-01-12 | 建明(中国)科技有限公司 | Preparation method of chromium propionate |
| CN115053937A (en) * | 2022-06-20 | 2022-09-16 | 浙江惠嘉生物科技股份有限公司 | Preparation method of chromium nicotinate nano dispersion preparation |
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