CN101780016B - Chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash and preparation method thereof - Google Patents
Chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash and preparation method thereof Download PDFInfo
- Publication number
- CN101780016B CN101780016B CN2009100454639A CN200910045463A CN101780016B CN 101780016 B CN101780016 B CN 101780016B CN 2009100454639 A CN2009100454639 A CN 2009100454639A CN 200910045463 A CN200910045463 A CN 200910045463A CN 101780016 B CN101780016 B CN 101780016B
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- CN
- China
- Prior art keywords
- chlorine dioxide
- compound formula
- mouth wash
- cetylpyridinium chloride
- formula mouth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 title claims abstract description 68
- 239000004155 Chlorine dioxide Substances 0.000 title claims abstract description 34
- 235000019398 chlorine dioxide Nutrition 0.000 title claims abstract description 34
- 239000002324 mouth wash Substances 0.000 title claims abstract description 30
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 30
- 229960001927 cetylpyridinium chloride Drugs 0.000 title claims abstract description 28
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 title claims abstract description 28
- -1 zinc ion compound Chemical class 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 150000001875 compounds Chemical class 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000012153 distilled water Substances 0.000 claims abstract description 17
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract description 15
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 14
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000004246 zinc acetate Substances 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 5
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 6
- 229940085605 saccharin sodium Drugs 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 4
- 239000002075 main ingredient Substances 0.000 claims description 4
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 2
- 239000011746 zinc citrate Substances 0.000 claims description 2
- 229940068475 zinc citrate Drugs 0.000 claims description 2
- 235000006076 zinc citrate Nutrition 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 abstract description 11
- 238000003756 stirring Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 6
- 239000000843 powder Substances 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract description 2
- 210000002200 mouth mucosa Anatomy 0.000 abstract description 2
- 239000000243 solution Substances 0.000 abstract 2
- 206010006326 Breath odour Diseases 0.000 abstract 1
- 208000032139 Halitosis Diseases 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 description 10
- 239000003814 drug Substances 0.000 description 7
- 238000005303 weighing Methods 0.000 description 6
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 150000003464 sulfur compounds Chemical class 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- 208000002064 Dental Plaque Diseases 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229960000282 metronidazole Drugs 0.000 description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and a preparation method thereof, wherein the main components of the raw materials are chlorine dioxide, cetylpyridinium chloride and zinc ion, wherein the solvent is distilled water, the concentration of the chlorine dioxide is 200-500 ppm, the cetylpyridinium chloride accounts for 0.05-0.2% of the mass fraction of the compound formula mouth wash, and the zinc ion accounts for 0.5-1% of the mass fraction of the compound formula mouth wash; the preparation method comprises dissolving cetylpyridinium chloride and zinc acetate in distilled water, dissolving Mentholum in 95% ethanol, adding Mentholum ethanol solution into water solution, stirring, and adding glycerol; dissolving chlorine dioxide powder in distilled water, adding the chlorine dioxide aqueous solution into the aqueous solution while stirring, uniformly mixing, and adding distilled water to obtain the compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ions. The invention has the advantages that: effectively inhibit halitosis for a long time, has small side effect and no obvious irritation to oral mucosa.
Description
[technical field]
The present invention relates to the collutory technical field, specifically, is a kind of chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash and preparation method thereof.
[background technology]
Implication is a kind of common oral cavity symptom; Series of factors by inside and outside the oral cavity causes, but in most of the cases, implication originates from oral cavity itself; Owing to anaerobe in the oral cavity under anaerobic metabolism aminoacid produce a series of products, main component is a volatile sulfur compounds gas.Medicine to implication mainly contains two types at present, at first is the medicine that can reduce anaerobe quantity in the oral cavity, and commonly used having possesses chlorhexidine, metronidazole, the cetylpyridinium chloride of fungistatic effect, trichlorohydroxyl phenylate etc.; Next is the medicine that can the volatile sulfur compounds gas in the implication be converted into nonvolatile matter, such as chlorine dioxide, zinc ion, hydrogen peroxide etc.Clinical experiment confirms that said medicine all can alleviate implication to a certain extent.Though possess medicine such as chlorhexidine, the metronidazole etc. of fungistatic effect certain curative effect is arranged, prolonged application can be destroyed the ecological balance in oral cavity, and is prone to make antibacterial to produce drug resistance, thereby can not life-time service.And use the medicine that can the volatile sulfur compounds gas in the implication be converted into nonvolatile matter, and such as chlorine dioxide, zinc ion, hydrogen peroxide etc., can only alleviate implication at short notice, stop using back 4 hours and can rebound with interior implication.Therefore, a kind of permanent efficient collutory of removing implication of research becomes one of hot issue of research.
[summary of the invention]
The objective of the invention is to overcome the deficiency of prior art, a kind of chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash and preparation method thereof are provided.
The objective of the invention is to realize through following technical scheme:
A kind of chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash, its raw material Main Ingredients and Appearance is a chlorine dioxide, cetylpyridinium chloride and zinc ion, adjuvant are Mentholum, saccharin sodium, 95% ethanol, glycerol; The mass fraction that cetylpyridinium chloride accounts for compound formula mouth wash is 0.05～0.2%; The mass fraction that zinc ion accounts for compound formula mouth wash is 0.5～1%; The mass fraction that chlorine dioxide accounts for compound formula mouth wash is 200～500mg/L; The mass fraction that Mentholum accounts for compound formula mouth wash is 0.4g/L, and the mass fraction that saccharin sodium accounts for compound formula mouth wash is 0.3g/L, and the volume fraction that ethanol accounts for compound formula mouth wash is 60ml/L; The volume fraction that glycerol accounts for compound formula mouth wash is 80ml/L, and surplus is a distilled water; Zinc ion is selected from a kind of in zinc acetate or the zinc citrate; Chlorine dioxide concentration is 200～500ppm;
The concrete steps of its preparation method do, cetylpyridinium chloride and zinc acetate are dissolved in the distilled water, and Mentholum is dissolved in 95% ethanol, Mentholum ethanol liquid is added in the aqueous solution stir, and add glycerol simultaneously; Other gets the chlorine dioxide powder and is dissolved in the distilled water, and aqueous solution of chlorine dioxide is added in the aqueous solution, and the limit edged stirs, and mixing also adds distilled water, obtains chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash.
Compared with prior art, good effect of the present invention is:
Chlorine dioxide belongs to the peroxide disinfectant; Suppress implication thereby make it to become tasteless product through the volatile sulfur compounds in the direct oxidation implication, the collutory that contains chlorine dioxide can obviously reduce the implication degree behind rinsing the mouth, and cetylpyridinium chloride belongs to cationic surfactant; Can cause that cell membrane is disorderly; Reach the bacteriostatic effect and then alleviate implication,, can make the formation of dental plaque reduce by 30% with gargling for 3～4 times the gargarism every day that contains cetylpyridinium chloride; Zinc ion can reduce the metabolic activity of antibacterial in the dental plaque, reaches the effect that suppresses bacterial plaque, and can through with saliva in calcium ion replace, combines with materials such as carboxyl, phosphate, be able to delay for a long time in the oral cavity, obtain slow persistent release.
Extremely strong good antibacterial effect and the zinc ion of Oxidation, cetylpyridinium chloride of the comprehensive chlorine dioxide of the present invention can be detained in the oral cavity for a long time, and the slowly lasting advantage that discharges with the synthetic compound preparation of above-mentioned three kinds of drug group, reaches the permanent effect that effectively suppresses implication.
Chlorine dioxide, cetylpyridinium chloride and zinc ion do not belong to antibiotic, and life-time service can not destroy the oral cavity flora balance, and side effect is less; Oral mucosa there is not obvious irritation; Clinical trial confirms, after gargling with compound formula mouth wash, the implication value has reduced 93% in 3 hours; And still effective after 8～10 hours, the implication value is controlled at lower level.
[specific embodiment]
The specific embodiment of chlorine dioxide of the present invention, cetylpyridinium chloride and zinc ion compound formula mouth wash and preparation method thereof below is provided.
Embodiment 1
Raw material is that cetylpyridinium chloride, zinc acetate, chlorine dioxide are Main Ingredients and Appearance, and adjuvant is Mentholum, 95% ethanol, glycerol, distilled water, saccharin sodium.
Precision takes by weighing 0.5g cetylpyridinium chloride, 2.5g zinc acetate and 0.15g saccharin sodium, is dissolved in about 300ml distilled water, and other takes by weighing the 0.2g Mentholum and is dissolved in 30ml 95% ethanol, Mentholum ethanol liquid is added in the aqueous solution stir, and adds 40ml glycerol with method; Precision takes by weighing 2.86g chlorine dioxide powder in addition, is dissolved in about 80ml distilled water, and aqueous solution of chlorine dioxide is added in the aqueous solution, and the limit edged stirs, and mixing adds distilled water to 500ml, and mixing promptly obtains compound formula mouth wash.
Embodiment 2
Raw material is that cetylpyridinium chloride, zinc acetate, chlorine dioxide are Main Ingredients and Appearance, and adjuvant is Mentholum, 95% ethanol, glycerol, distilled water.
Precision takes by weighing 0.5g cetylpyridinium chloride and 2.5g zinc acetate, is dissolved in about 300ml distilled water, and other takes by weighing the 0.2g Mentholum and is dissolved in 30ml 95% ethanol, Mentholum ethanol liquid is added in the aqueous solution stir, and adds 40ml glycerol with method; Precision takes by weighing 2.1g chlorine dioxide powder in addition, is dissolved in about 80ml distilled water, and aqueous solution of chlorine dioxide is added in the aqueous solution, and the limit edged stirs, and mixing adds distilled water to 500ml, and mixing promptly obtains compound formula mouth wash.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the present invention's design; Can also make some improvement and retouching, these improvement and retouching also should be regarded as in protection scope of the present invention.
Claims (2)
1. a chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash is characterized in that, its raw material Main Ingredients and Appearance is chlorine dioxide, cetylpyridinium chloride and zinc ion, and adjuvant is Mentholum, saccharin sodium, ethanol, glycerol; The mass fraction that cetylpyridinium chloride accounts for compound formula mouth wash is 0.05～0.2%; The mass fraction that zinc ion accounts for compound formula mouth wash is 0.5～1%; The mass fraction that chlorine dioxide accounts for compound formula mouth wash is 200～500mg/L; The mass fraction that Mentholum accounts for compound formula mouth wash is 0.4g/L, and the mass fraction that saccharin sodium accounts for compound formula mouth wash is 0.3g/L, and the volume fraction that ethanol accounts for compound formula mouth wash is 60ml/L; The volume fraction that glycerol accounts for compound formula mouth wash is 80ml/L, and surplus is a distilled water.
2. chlorine dioxide as claimed in claim 1, cetylpyridinium chloride and zinc ion compound formula mouth wash is characterized in that, described zinc ion is selected from a kind of in zinc acetate or the zinc citrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100454639A CN101780016B (en) | 2009-01-16 | 2009-01-16 | Chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100454639A CN101780016B (en) | 2009-01-16 | 2009-01-16 | Chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101780016A CN101780016A (en) | 2010-07-21 |
| CN101780016B true CN101780016B (en) | 2012-05-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009100454639A Expired - Fee Related CN101780016B (en) | 2009-01-16 | 2009-01-16 | Chlorine dioxide, cetylpyridinium chloride and zinc ion compound formula mouth wash and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN101780016B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9138428B2 (en) * | 2010-08-07 | 2015-09-22 | The Research Foundation For The State University Of New York | Oral compositions comprising a zinc compound and an anti-microbial agent |
| CN102008399B (en) * | 2010-12-22 | 2013-06-12 | 韶关蓝威消毒药业有限公司 | Preparation method of antimicrobial mouthwash |
| CN102441006B (en) * | 2011-12-01 | 2016-06-01 | 刘学武 | A kind of hair-regrowth solution containing chlorine dioxide and preparation and application thereof |
| CN106109366A (en) * | 2016-08-30 | 2016-11-16 | 南京巨鲨显示科技有限公司 | A kind of collutory and preparation method thereof |
| CN107951733A (en) * | 2017-11-16 | 2018-04-24 | 江苏大学 | The preparation and its application of Azulene sodium sulfonate and Cetylpyridinium Chloride compound mouthwash |
| CN107753930A (en) * | 2017-11-16 | 2018-03-06 | 江苏大学 | The preparation and its application of nisin, Cetylpyridinium Chloride and sodium fluoride mouthwash |
| US12053485B2 (en) | 2018-06-25 | 2024-08-06 | Triumph Pharmaceuticals Inc. | Methods of inhibiting microbial infections using zinc-containing compositions |
| CN108743442A (en) * | 2018-07-17 | 2018-11-06 | 天津中鼎生物医学科技有限公司 | Sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash and preparation method |
| CA3164386A1 (en) | 2020-02-18 | 2021-08-26 | Kana Hashimoto | Oral care composition |
| CN116236404A (en) * | 2023-02-03 | 2023-06-09 | 克劳丽化妆品股份有限公司 | A kind of stable oral care product and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1649560A (en) * | 2002-03-04 | 2005-08-03 | 高露洁-棕榄公司 | Anti-microbial breath freshening mouthrinse |
| WO2007110790A1 (en) * | 2006-03-29 | 2007-10-04 | The Procter & Gamble Company | Oral care compositions having improved consumer aesthetics and taste |
| US20080247972A1 (en) * | 2005-06-03 | 2008-10-09 | Mauricio Duarte Da Conceicao | Mouthwash for the Prevention and Treatment of Halitosis |
-
2009
- 2009-01-16 CN CN2009100454639A patent/CN101780016B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1649560A (en) * | 2002-03-04 | 2005-08-03 | 高露洁-棕榄公司 | Anti-microbial breath freshening mouthrinse |
| US20080247972A1 (en) * | 2005-06-03 | 2008-10-09 | Mauricio Duarte Da Conceicao | Mouthwash for the Prevention and Treatment of Halitosis |
| WO2007110790A1 (en) * | 2006-03-29 | 2007-10-04 | The Procter & Gamble Company | Oral care compositions having improved consumer aesthetics and taste |
Non-Patent Citations (1)
| Title |
|---|
| 陈曦 等.口源性口臭的治疗.《国外医学口腔医学分册》.2004,第31卷(第6期), * |
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| CN101780016A (en) | 2010-07-21 |
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