CN101773130A - Bactericidal composition containing cyazofamid and propineb - Google Patents
Bactericidal composition containing cyazofamid and propineb Download PDFInfo
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- CN101773130A CN101773130A CN201010002689A CN201010002689A CN101773130A CN 101773130 A CN101773130 A CN 101773130A CN 201010002689 A CN201010002689 A CN 201010002689A CN 201010002689 A CN201010002689 A CN 201010002689A CN 101773130 A CN101773130 A CN 101773130A
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- CN
- China
- Prior art keywords
- propineb
- frost azoles
- cyanogen frost
- bactericidal composition
- cyanogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000005823 Propineb Substances 0.000 title claims abstract description 79
- KKMLIVYBGSAJPM-UHFFFAOYSA-L propineb Chemical compound [Zn+2].[S-]C(=S)NC(C)CNC([S-])=S KKMLIVYBGSAJPM-UHFFFAOYSA-L 0.000 title claims abstract description 79
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 31
- 239000005754 Cyazofamid Substances 0.000 title abstract description 6
- YXKMMRDKEKCERS-UHFFFAOYSA-N cyazofamid Chemical compound CN(C)S(=O)(=O)N1C(C#N)=NC(Cl)=C1C1=CC=C(C)C=C1 YXKMMRDKEKCERS-UHFFFAOYSA-N 0.000 title abstract description 6
- 201000010099 disease Diseases 0.000 claims abstract description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 21
- 241000233866 Fungi Species 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 claims description 136
- 150000003851 azoles Chemical class 0.000 claims description 68
- 239000004562 water dispersible granule Substances 0.000 claims description 21
- 238000009472 formulation Methods 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 19
- 238000009736 wetting Methods 0.000 claims description 14
- 235000013399 edible fruits Nutrition 0.000 claims description 4
- 235000013311 vegetables Nutrition 0.000 claims description 4
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 claims description 3
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims description 3
- 239000012752 auxiliary agent Substances 0.000 claims description 3
- 239000003905 agrochemical Substances 0.000 claims description 2
- 241000219112 Cucumis Species 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000002195 synergetic effect Effects 0.000 abstract description 7
- 238000012360 testing method Methods 0.000 abstract description 7
- 238000002156 mixing Methods 0.000 abstract description 4
- 230000002265 prevention Effects 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000000575 pesticide Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 23
- 239000000945 filler Substances 0.000 description 20
- 239000002270 dispersing agent Substances 0.000 description 19
- 239000000080 wetting agent Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 15
- 241000233679 Peronosporaceae Species 0.000 description 13
- 206010039509 Scab Diseases 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 12
- 240000008067 Cucumis sativus Species 0.000 description 11
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 11
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 10
- 240000003768 Solanum lycopersicum Species 0.000 description 10
- 239000007884 disintegrant Substances 0.000 description 10
- 238000009700 powder processing Methods 0.000 description 7
- 238000003672 processing method Methods 0.000 description 7
- 238000011835 investigation Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241000233614 Phytophthora Species 0.000 description 5
- 239000003899 bactericide agent Substances 0.000 description 5
- 239000000417 fungicide Substances 0.000 description 5
- 231100000572 poisoning Toxicity 0.000 description 5
- 230000000607 poisoning effect Effects 0.000 description 5
- 230000003449 preventive effect Effects 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- -1 sulphaguanidine azoles Chemical class 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- JHXVRRJXCDAINK-UHFFFAOYSA-N NC(=O)N.N#CC#N Chemical compound NC(=O)N.N#CC#N JHXVRRJXCDAINK-UHFFFAOYSA-N 0.000 description 4
- 244000183278 Nephelium litchi Species 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000000855 fungicidal effect Effects 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 244000241257 Cucumis melo Species 0.000 description 3
- 102100025287 Cytochrome b Human genes 0.000 description 3
- 108010075028 Cytochromes b Proteins 0.000 description 3
- 241000233654 Oomycetes Species 0.000 description 3
- 241000233622 Phytophthora infestans Species 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000002438 mitochondrial effect Effects 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000008635 plant growth Effects 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- AMHNZOICSMBGDH-UHFFFAOYSA-L zineb Chemical compound [Zn+2].[S-]C(=S)NCCNC([S-])=S AMHNZOICSMBGDH-UHFFFAOYSA-L 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 241001465180 Botrytis Species 0.000 description 1
- 235000011331 Brassica Nutrition 0.000 description 1
- 241000219198 Brassica Species 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 235000009847 Cucumis melo var cantalupensis Nutrition 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 239000005807 Metalaxyl Substances 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 241001503464 Plasmodiophora Species 0.000 description 1
- 241001503460 Plasmodiophorida Species 0.000 description 1
- 241000233639 Pythium Species 0.000 description 1
- 240000003377 Shepherdia canadensis Species 0.000 description 1
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 231100000605 Toxicity Class Toxicity 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- ZQEIXNIJLIKNTD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate Chemical compound COCC(=O)N(C(C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-UHFFFAOYSA-N 0.000 description 1
- BSDQITJYKQHXQR-UHFFFAOYSA-N methyl prop-2-eneperoxoate Chemical compound COOC(=O)C=C BSDQITJYKQHXQR-UHFFFAOYSA-N 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960004257 sulfaguanidine Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing cyazofamid and propineb, a preparation method and application thereof. The bactericidal composition is characterized by containing the cyazofamid, the propineb and other assistants, wherein the weight ratio of the cyazofamid to the propineb is 1 to 50:1 to 80. The bactericidal composition can be applied to the prevention and the treatment of diseases caused by the lower fungi of various crops. The composition has high safety, environmental protection, low cost and good effect. Indoor and field test of pesticide effectiveness proves that the composition has an obvious synergistic action. Moreover, the report relevant to the mixing and the matching of the cyazofamid and the propineb never occurs at home and abroad, so the invention is provided.
Description
Technical field
The invention belongs to the agriculture chemical compounding field, relate to a kind of bactericidal composition and application thereof, especially a kind of is the bactericidal composition and the application thereof of main active with cyanogen frost azoles and Propineb.
Background technology
Cyanogen frost azoles:
Belong to therapeutic sulphaguanidine azoles fungicide, the plasmodiophora brassica bacteria of Oomycete fungi such as phytophthora, downy mildew, false downy mildew, pythium spp and Plasmodiophoromycetes is had very high biologically active.A kind of in the mitochondrial respiratory inhibitor, the electronics transmission that can block mitochondrial cytochrome b c1 complex in the Oomycete germ body comes the supply of interfering energy, its binding site is the Q1 center of enzyme, is different from methoxy acrylate (being Q0 inhibitor among the cytochrome b c1).There is not cross tolerance with other bactericide.Use in the field has good control efficiency to late blight and downy mildew, and using dosage as handling potato late blight with the concentration of 50～100mg/L outstanding control efficiency is arranged, and the medication phase is flexible, the lasting period is long than low 2～38 times of other bactericide.Downy mildew with the chemicals treatment grape of same concentration, cucumber, muskmelon also has fabulous control efficiency.
Cyanogen frost azoles is a Q1 inhibitor among the cytochrome b c1, and all vegetative stages of oomycetes are all had effect, and the germ that metalaxyl is produced resistance or sensitivity all has activity.But its therapeutic action is strong, and protectiveness is relatively poor.
Propineb: acrylic bisdithiocarbamic zinc
Propineb is a kind of wide spectrum, quick-acting protective fungicide.The safe and sound life of other titles.Preparation has 70% Wettable propineb powder.Physicochemical property: 70% Wettable propineb powder is a cream-coloured powder.Have special smell, density 0.28, pH5.2, suspension stability are greater than 75%, and the moistening time, water content was less than 2.5% less than 120 seconds, and storage at normal temperature stability is more than 2 years.Toxicity: by Chinese pesticide toxicity grading criteria, Propineb belongs to the low toxicity bactericide.Nontoxic to honeybee.Mechanism of action: the bactericidal mechanism of Propineb is for suppressing the oxidation of pyruvic acid in the cause of disease thalline.Propineb is the protective fungicide of long, wide spectrum of a kind of quick-acting, longevity of residure; downy mildew of crops such as vegetables, tobacco, lupulus and morning, the late blight of tomato and potato all there are good protective action, and the germ disease of powdery mildew, rust and Botrytis is also had certain inhibitory action.But its therapeutic action to disease is relatively poor, and composite with the curative fungicide agent is to select preferably.
Summary of the invention
The present invention be directed to the problems referred to above a bactericidal composition that contains cyanogen frost azoles and Propineb applied widely, that cost is low, effective is provided.
A further object of the invention provides the purposes of this bactericidal composition.
A kind of bactericidal composition, it contains cyanogen frost azoles and Propineb, and wherein the weight ratio of cyanogen frost azoles and Propineb is 1～50: 1～80.
Described bactericidal composition, wherein the more excellent weight ratio of cyanogen frost azoles and Propineb is 1～50: 10～80.
Described bactericidal composition, wherein to account for the weight fraction ratio of preparation be 11～80% to active ingredient.
Described bactericidal composition, cyanogen frost azoles and Propineb and auxiliary agent, carrier etc. are processed into any one formulation that allows on the agricultural chemicals.
Described bactericidal composition is characterized in that the formulation that can be processed into is wetting powder, water dispersible granules.
Application aspect the disease that described bactericidal composition causes the multiple lower funguses of control fruit tree, melon and vegetables etc.
Microbicide compositions with synergistic effect takes following measure to realize:
Contain cyanogen frost azoles and two kinds of active components of Propineb in the composition, wherein the weight ratio of cyanogen frost azoles and Propineb is 1～50: 1～80, more excellent weight ratio is 1～50: 10～80, and the active ingredient of composition adds auxiliary agent and filler can be processed into wetting powder, water dispersible granules.
When said composition was made wetting powder, constituent content was:
Cyanogen frost azoles 1～50g
Propineb 1～80g
Dispersant 3～20g
Wetting agent 3～10g
Filler 10～70g
The concrete procedure of processing of this bactericidal composition wetting powder is: press above-mentioned prescription with cyanogen frost azoles and Propineb and dispersant, wetting agent and filler mixing, in stirred tank, evenly stir, behind airslide disintegrating mill, mixing, promptly can be made into the wetting powder of the present composition.
When said composition was made water dispersible granules, constituent content was:
Cyanogen frost azoles 1～50g
Propineb 1～80g
Dispersant 3～20g
Wetting agent 3～10g
Disintegrant 2～5g
Filler 10～70g
The concrete procedure of processing of this bactericidal composition water dispersible granules is: by above-mentioned prescription cyanogen frost azoles, Propineb and dispersant, wetting agent, disintegrant and filler are mixed, pulverize with micro jet, through mediating, add then and carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis makes the water dispersible granules that contains the bactericidal composition of cyanogen frost azoles of the present invention.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, the fatty acid glyceride APEO.
The choosing of described wetting agent is white: lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX., among the wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene triphenylethylene phosphenylic acid salt, spaonin powder, silkworm excrement, soapberry powder one or more.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
The invention has the beneficial effects as follows:
1, the used cyanogen frost azoles of the present invention is the triazole bactericidal agent of strong interior absorption, has very strong therapeutic action and has the certain protection effect concurrently, and Propineb is a gloomy class protective fungicide of generation, and phase spray medicine must or start before disease takes place.Cyanogen frost azoles and Propineb are mixed mutually and can produce conflict, but Synergistic reduces dosage, reduces cost.
2, this composition scope of application increases, and is applicable to the disease that the multiple lower funguses of fruit tree, melon and vegetables etc. causes, as downy mildew, eqpidemic disease etc.
3, composite two kinds of bactericide double action mechanism delay the drug-fast generation of germ.
4, the pathogen that produces resistance there is good preventive effect.
Application Example
Example of formulations
Example of formulations 1:
Cyanogen frost azoles 1g, Propineb 80g, dispersant 3g, wetting agent 5g, the filler surplus according to above-mentioned wetting powder processing method, makes 81% cyanogen frost azoles Wettable propineb powder.
Example of formulations 2:
Cyanogen frost azoles 5g, Propineb 70g, dispersant 8g, wetting agent 5g, the filler surplus according to above-mentioned wetting powder processing method, makes 75% cyanogen frost azoles Wettable propineb powder.
Example of formulations 3:
Cyanogen frost azoles 15g, Propineb 50g dispersant 10g, wetting agent 10g, the filler surplus according to above-mentioned wetting powder processing method, makes 65% cyanogen frost azoles Wettable propineb powder.
Example of formulations 4:
Cyanogen frost azoles 15g, Propineb 35g, dispersant 10g, wetting agent 10g, the filler surplus according to above-mentioned wetting powder processing method, makes 50% cyanogen frost azoles Wettable propineb powder.
Example of formulations 5:
Cyanogen frost azoles 30g, Propineb 25g, dispersant 10g, wetting agent 10g, the filler surplus according to above-mentioned wetting powder processing method, makes 55% cyanogen frost azoles Wettable propineb powder.
Example of formulations 6:
Cyanogen frost azoles 40g, Propineb 15g, dispersant 10g, wetting agent 10g, the filler surplus according to above-mentioned wetting powder processing method, makes 55% cyanogen frost azoles Wettable propineb powder.
Example of formulations 7:
Cyanogen frost azoles 50g, Propineb 2g, dispersant 10g, wetting agent 10g, the filler surplus according to above-mentioned wetting powder processing method, makes 52% cyanogen frost azoles Wettable propineb powder.
Example of formulations 8:
Cyanogen frost azoles 1g, Propineb 80g dispersant 3g, wetting agent 3g, disintegrant 2g, the filler surplus according to above-mentioned water dispersible granules processing method, makes 81% cyanogen frost azoles Propineb water dispersible granules.
Example of formulations 9:
Cyanogen frost azoles 5g, Propineb 70g, dispersant 5g, wetting agent 5g, disintegrant 3g, the filler surplus according to above-mentioned water dispersible granules processing method, makes 75% cyanogen frost azoles Propineb water dispersible granules.
Example of formulations 10:
Cyanogen frost azoles 15g, Propineb 50g dispersant 10g, wetting agent 8g, disintegrant 2g, the filler surplus according to above-mentioned water dispersible granules processing method, makes 65% cyanogen frost azoles Propineb water dispersible granules.
Example of formulations 11:
Cyanogen frost azoles 15g, Propineb 35g, dispersant 10g, wetting agent 10g, disintegrant 2g, the filler surplus according to above-mentioned water dispersible granules processing method, makes 50% cyanogen frost azoles Propineb water dispersible granules.
Example of formulations 12:
Cyanogen frost azoles 30g, Propineb 25g, dispersant 10g, wetting agent 10g, disintegrant 2g, the filler surplus according to above-mentioned water dispersible granules processing method, makes 55% cyanogen frost azoles Propineb water dispersible granules.
Example of formulations 13:
Cyanogen frost azoles 40g, Propineb 15g, dispersant 10g, wetting agent 10g, disintegrant 2g, the filler surplus according to above-mentioned water dispersible granules processing method, makes 55% cyanogen frost azoles Propineb water dispersible granules.
Example of formulations 14:
Cyanogen frost azoles 50g, Propineb 2g, dispersant 10g, wetting agent 8g, disintegrant 2g, the filler surplus according to above-mentioned water dispersible granules processing method, makes 52% cyanogen frost azoles Propineb water dispersible granules.
Specific embodiment
The different proportioning co-toxicities of cyanogen frost azoles with Propineb
1 materials and methods
The design 1.1 material and medicament are mixed
1.1.1 is peronophythora litchi (P.litchic) for examination bacterium source for the examination pathogen.
1.1.2 reagent agent 93.5% cyanogen frost azoles water dispersible granules, 98% Wettable propineb powder.
1.2 the toxicity test of single agent
Adopt the mycelial growth rate determination method.Reagent agent cyanogen frost azoles and Propineb are mixed with the mother liquor of high concentration respectively, dilute the solution of 5 variable concentrations respectively, join in the quantitative PDA medium.Every concentration is handled and is all established 4 repetitions.The peronophythora litchi bacterium piece of cultivating in advance (d=4mm) is placed the dull and stereotyped central authorities of pastille PDA, and constant temperature (24 ℃) dark culturing is measured colony diameter behind the 9d.Compare with blank, calculate the fungistatic effect of each processing, utilize the DPS data handling system that result of the test is carried out significance of difference analysis and calculated the toxicity test result of reagent agent to peronophythora litchi mycelial growth.
2.1 the evaluation of synergistic effect:
Method with (1985) such as Gisi has been carried out synergy mensuration.Gisi etc. are with the EC of each single agent
50The mixing ratio of value and medicament is calculated as follows the theoretical EC of mixture
50Value (th) is again with the EC of this theoretical value and actual measurement
50Value is compared (R value=EC
50Theoretical value/EC
50Measured value), greater than 1.5 o'clock, then can think the tool synergistic effect as the result.
EC
50(th)＝(a+b)/【a/EC
(A)，+b/EC
(B)】
EC
(A), (the EC of A agent
50, measured value)
EC
(B), (the EC of B agent
50, measured value)
2.1.1 examination is made as the white azoles of 60% cyanogen according to cyanogen frost azoles and Propineb total active constituent content that is mixed: Propineb was established 1: 3,1: 4,1: 5,1: 6,1: 7 by former medicine mass ratio, and promptly 5 ratios such as 15%+45%, 12%+48%, 10%+50%, 8.57%+51.43%, 7.5%+52.5% are mixed.The combination that is mixed of 5 cyanogen frost azoles Propinebs, fully vibrating in the sterilization triangular flask that adds 3mL watery hydrochloric acid in advance makes its dissolving, and adding an amount of sterile water, to make 500 each 50mL of μ g/mL mother liquor standby.5 concentration gradients are established in the combination that respectively is mixed of cyanogen frost azoles Propineb, and make blank with the watery hydrochloric acid of same concentrations, each is handled and repeats 4 times.Carry out according to 1.2 test methods, and the classification investigation state of an illness condition of getting a haircut everywhere, disease index and control efficiency calculated.Adopt DPS 2000 data processing softwares to calculate virulence regression equation formula, EC
50Equivalent.Data see Table 1.
The cyanogen frost azoles Propineb mixture of the different proportionings of table 1 suppresses virulence and synergistic effect to peronophythora litchi
2 results and analysis
Each mixture synergism coefficient that cyanogen frost azoles and Propineb are mixed is all greater than 1, but cyanogen frost azoles: 1: 5 combination S R value that is mixed of Propineb is up to 1.77, greater than 1.5, shows as synergistic function, remaining 4 be mixed combination S R value all less than 1.5 greater than 1, show as summation action.
3 field trials are surveyed cucumber downy mildew and tomato late blight
3.1 test method
3.1.1 application method
Test is total to dispenser three times, check plot spray equivalent clear water.When making up a prescription, after with low amounts of water medicament fully being dissolved earlier, add suitable quantity of water again and carry out complete stool spraying processing, even spraying.With WF-16 type knapsack hand sprayer spray medicine, shower nozzle is single fan nozzle, water outlet aperture 1mm, and operating pressure is 0.2-0.4Mpa, spray amount is 0.36-0.48L/min.The sub-district spouting liquid is used by 675 liters/hectare, with the following droplet degree of being not of soup on moistening blade of soup and the branch.
3.1.2 investigation method
Cucumber downy mildew: every sub-district is got 4 points at random, whole blades of every some investigation 2 strains, and every leaf accounts for the percentage classification of leaf area by scab, write down total number of sheets, the sick number of sheets at different levels, calculate the blade incidence of disease, disease index, refer to comparison, calculate relative control effect with the contrast disease.
State of an illness grade scale (is unit with the blade)
0 grade: no scab;
1 grade: the sick area of scab accounts for whole leaf area below 5%;
3 grades: the sick area of scab accounts for whole leaf area 6%～10%;
5 grades: the sick area of scab accounts for whole leaf area 11%～25%;
7 grades: the sick area of scab accounts for whole leaf area 26%～50%;
9 grades: the sick area of scab accounts for whole leaf area more than 50%.
Tomato late blight: every sub-district is 5 samplings at random, whenever click two strains, every strain divides the upper, middle and lower investigation 10 leaves, the percentage that accounts for whole leaf area with the lesion area on the every leaf comes classification to write down total number of sheets, the sick number of sheets at different levels, calculate the blade incidence of disease, disease index, refer to comparison with the contrast disease, calculate relative control effect.
State of an illness grade scale (is unit with the blade)
0 grade: no scab;
1 grade: the sick area of scab accounts for whole leaf area below 5%;
3 grades: the sick area of scab accounts for whole leaf area 6%～10%;
5 grades: the sick area of scab accounts for whole leaf area 11%～20%;
7 grades: the sick area of scab accounts for whole leaf area 21%～50%;
9 grades: the sick area of scab accounts for whole leaf area more than 50%.
3.1.3 control time and number of times
Test is investigated 5 times altogether, radix investigation before the medicine, behind the medicine 7 days for the first time, for the second time behind the medicine 7 days, investigated in 10 days behind 7 days and the 4th medicine behind the medicine for the third time.
3.1.4 drug effect computational methods
Sick leaf rate (the %)=sick number of sheets/investigate total number of sheets * 100
Disease index=∑ (the sick numbers of sheets at different levels * relative level numerical value)/(investigating total number of sheets * 9) * 100
Control efficiency (%)=(1-(disease index behind disease index before the blank district medicine * treatment region medicine)/(disease index before disease index behind the blank district medicine * treatment region medicine)) * 100
3.1.5 poisoning investigation method
Whether continuous 7d range estimation medicament has poisoning to crop after the dispenser.
3.2 result of the test and analysis
3.2.1 each handles the effect (seeing Table 2) of control cucumber downy mildew
Each handles the effect of control cucumber downy mildew table 2
As can be seen from Table 2,60% cyanogen frost azoles: Propineb can be good at controlling the generation of cucumber downy mildew with 1: 5 the combination that is mixed, the effect of 7 days control cucumber downy mildews is better than 60% white urea cyanogen Propineb WP behind its 1 medicine, also be better than two kinds of single agent of 70% Propineb and 10% cyanogen frost azoles, have good quick-acting; 10 days the highest preventive effect can reach 88.96% behind its 4 medicines, is higher than the preventive effect of two kinds of single agent of 60% white urea cyanogen Propineb WP and 50% Carbatene and 50% cyanogen frost azoles far away, has fine continuation.According to field range estimation, in the test dose scope, plant growth is normal, and each is handled medicament and poisoning phenomenon to cucumber all do not occur, illustrates that it is safe to cucumber.
3.2.1 each handles the effect (seeing Table 3) of control tomato late blight
Each handles the effect of control tomato late blight table 3
As can be seen from Table 3,60% cyanogen frost azoles: Propineb with 1: 5 its 1 medicine of combination control tomato late blight that is mixed after 7 days control efficiency be better than 60% white urea cyanogen Propineb WP, also be better than two kinds of single agent of 70% Propineb and 10% cyanogen frost azoles, have good quick-acting; 10 days preventive effect can reach 81.62%-84.21% behind its 4 medicines, is higher than the preventive effect of two kinds of single agent of 60% white urea cyanogen Propineb WP and 50% Carbatene and 50% cyanogen frost azoles far away, has fine continuation; 60% cyanogen frost azoles: Propineb has good control efficiency with 1: 5 the combination that is mixed to tomato late blight, can be good at controlling the generation of tomato late blight.According to field range estimation, in the test dose scope, plant growth is normal, and each is handled medicament and poisoning phenomenon to tomato all do not occur, illustrates that it is safe to tomato.
In sum, the present invention contains the bactericidal composition of cyazofamid and Propineb, cucumber downy mildew, cucumber early blight, tomato late blight and Apple little leaf etc. are all had better prevention and result for the treatment of, and it is to the target crop safety, compares with single dose, bactericidal composition of the present invention has the advantage that quick-acting is good, the lasting period long, do not pollute the fruit face, be easy to transportation and use, environmental pollution is few, is difficult for producing poisoning, so research and development of the present invention and popularization are of great significance social tool.
Claims (6)
1. bactericidal composition is characterized in that: contain cyanogen frost azoles and two kinds of active components of Propineb, wherein the weight ratio of cyanogen frost azoles and Propineb is 1～50: 1～80;
2. bactericidal composition according to claim 1 is characterized in that: the more excellent weight ratio of cyanogen frost azoles and Propineb is 1～50: 10～80;
3. bactericidal composition according to claim 1 is characterized in that: the percentage by weight that cyanogen frost azoles and Propineb are accumulated shared preparation is 11～80%;
4. bactericidal composition according to claim 1 is characterized in that: cyanogen frost azoles and Propineb and auxiliary agent and cosolvent are re-dubbed any one formulation that allows on the agricultural chemicals;
5. bactericidal composition according to claim 1 is characterized in that: the formulation that can be processed into is formulations such as wetting powder and water dispersible granules;
6. bactericidal composition according to claim 1 is characterized in that: can be used for preventing and treating the multiple diseases that various crop lower funguses such as fruit tree, melon and vegetables cause.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103562158A (en) * | 2010-12-31 | 2014-02-05 | 拜耳知识产权股份有限公司 | Method for improving plant quality |
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|---|---|---|---|---|
| CN1288663A (en) * | 2000-06-22 | 2001-03-28 | 张长兴 | Germicide for preventing and controlling grey mold of vegetable |
| CN101444217A (en) * | 2008-12-27 | 2009-06-03 | 深圳诺普信农化股份有限公司 | Composite with tericidal action containing prochloraz-manganese chloride complex and mancozeb |
| CN101658179A (en) * | 2009-07-22 | 2010-03-03 | 深圳诺普信农化股份有限公司 | Complex bactericidal composition containing cyazofamid |
| CN101700014A (en) * | 2009-11-30 | 2010-05-05 | 青岛星牌作物科学有限公司 | A kind of bactericidal composition and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1288663A (en) * | 2000-06-22 | 2001-03-28 | 张长兴 | Germicide for preventing and controlling grey mold of vegetable |
| CN101444217A (en) * | 2008-12-27 | 2009-06-03 | 深圳诺普信农化股份有限公司 | Composite with tericidal action containing prochloraz-manganese chloride complex and mancozeb |
| CN101658179A (en) * | 2009-07-22 | 2010-03-03 | 深圳诺普信农化股份有限公司 | Complex bactericidal composition containing cyazofamid |
| CN101700014A (en) * | 2009-11-30 | 2010-05-05 | 青岛星牌作物科学有限公司 | A kind of bactericidal composition and application |
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| CN103562158A (en) * | 2010-12-31 | 2014-02-05 | 拜耳知识产权股份有限公司 | Method for improving plant quality |
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