CN101669998B - Corydalis saxicola pill and preparation method thereof - Google Patents

Abstract

The Yanhuanglian dripping pill and a preparation method thereof relate to a Chinese patent medicine which takes the Yanhuanglian medicinal material as a raw material and mainly treats diseases such as the liver, and a preparation method thereof. Yanhuanglian dripping pills are made from 1 part of Yanhuanglian extract and 4-6 parts of polyethylene glycol. Yanhuanglian extract is the dry product obtained by extracting the medicinal material of Yanhuanglian with 50-70% ethanol aqueous solution, which is absorbed by macroporous resin, eluted with 50-70% ethanol aqueous solution, and the eluent is concentrated and dried. The weight contains more than 55 percent of the total alkaloids of the rhizome, and the dehydrocarvetine accounts for more than 10 percent of the weight of the dry product of the rhizome extract. Each gram of Yanhuanglian dripping pills contains 85-135 mg of total alkaloids of Yanhuanglian; 18-45 mg of dehydrocarvetine. The product has the advantages of high bioavailability and is an oral preparation capable of exerting high-efficiency and quick-acting effects; the production process and equipment of the dropping pill preparation are simple, the production cycle is short, the production efficiency is high, and the cost is low.

Description

Yanhuanglian dripping pills and preparation method thereof

technical field

The invention relates to a Chinese patent medicine which takes plants as raw materials and mainly treats diseases such as the liver and a preparation method thereof, in particular to a dripping pill made of rock rhizoma rhizomes as a raw material and a preparation method thereof.

Background technique

Rock yellow is the dry whole plant of the perennial herbaceous plant Corydalis saxicola Bunting in the family Papaveraceae. This product is cool and bitter in taste, has the functions of clearing heat and detoxifying, promoting dampness and relieving pain, dispelling blood stasis and reducing swelling, etc.

At present, the preparations of Yanhuanglian are only available in injection injections, such as Yanhuanglian injection produced by Guangxi Hefeng Pharmaceutical Co., Ltd., Z20046725, specifications: 2mL per tube, containing lithosine Vitin) 0.7mg, administered by intravenous infusion, but Yanhuanglian Injection has been reported to cause individual allergic reactions in clinical use, manifested as itching, palpitation, chills, fever, and occasionally nausea, vomiting etc.

CN1453277A also discloses a total alkaloid of Litectin and its preparation method and application. It also discloses that Litectin is extracted with an organic solvent, then purified by acid-dissolving and alkali-precipitating, and then purified with macroporous resin, and discloses the preparation of the extract Capsules, granules, oral liquids and tablets, but the content of the total alkaloids of Litectin in the extract of the said patent is only 50%, and the content of dehydrocarvetine is only 6.8%. Moreover, the preparation process is complicated, and the bioavailability of the prepared oral preparation is low.

For this reason, it is necessary to develop an oral preparation with high bioavailability, rapid drug release, rapid effect, and small toxic and side effects, and improve the preparation method of the extract of Litectin, make the method easier, and the active ingredients Litectin total alkaloids and dehydrogenation Carvitin is even higher.

Contents of the invention

The object of the present invention is to make up for the deficiencies of the prior art, to provide a kind of Yanhuanglian dripping pills and its preparations with high bioavailability, fast drug release, rapid effect, high active ingredient content of Yanhuanglian in the preparation, and convenient clinical use and portability. Preparation.

To achieve the technical solution adopted for the purpose of the present invention: Yanhuanglian dripping pills are made from the raw materials of the following parts by weight

Litectin extract 1 part

4-6 parts of polyethylene glycol

The extract of Litectin Rhizoma is extracted with 50-70% (V/V) aqueous ethanol solution of Litectin Rhizoma, and the obtained extract is adsorbed by macroporous resin and eluted with 50-70% (V/V) aqueous ethanol , the dry product obtained by concentrating and drying the eluent contains more than 55% (W/W) of total alkaloids of rhizome in the dry product weight, wherein dehydrocarvetine (also known as alkaloids of rhizome) in total alkaloids of rhizomes accounts for More than 10% (W/W) of the dry product weight of Coptis chinensis extract,

The Yanhuanglian dropping pills contain 80-135 mg of total alkaloids of Yanhuanglian per gram of the dropping pills, and 18-45 mg of dehydrocarvetine per gram of the dropping pills.

The polyethylene glycol may preferably have a molecular weight of 4000 or/and a molecular weight of 6000, and the weight ratio of polyethylene glycol 4000: polyethylene glycol 6000 is 5-0: 0-5, and preferably polyethylene glycol The weight ratio of ethylene glycol 4000: polyethylene glycol 6000 is 4:1 or 3:2 or 1:1, especially the weight ratio of polyethylene glycol 4000: polyethylene glycol 6000 is 4:1.

The preparation method of Yanhuanglian dripping pills provided by the present invention is carried out in the following steps:

Step 1: Preparation of Litectin Rhizoma Extract: Take Litectin Rhizoma Radix, reflux 1-3 times with 6-10 times 50-70% (V/V) ethanol aqueous solution each time, 1-2 hours each time, combine extracts, reduce After recovering ethanol, concentrate to a volume that is 5 times of the weight of the Radix Rhizoma medicinal material (that is, feed 1 kilogram of Radix Rhizoma Rhizoma Medicinal Material, and the concentrated solution is 5 liters), filter the solution, and get the filtrate to absorb with macroporous resin. 70% (V/V) ethanol aqueous solution was used for elution, and the eluate was collected, concentrated, and dried to obtain the extract of Litectin Rhizoma;

Step 2 Ingredients: According to the weight ratio of Litectin Rhizoma: Polyethylene glycol weight ratio of 1:4-6, weigh the Litectin Rhizoma extract and polyethylene glycol respectively, first heat the polyethylene glycol to melt, and stir Add the rock rhizome extract, and mix well to obtain a mixed solution;

Step 3 Dropping: Add the mixed liquid into the dripping device of the dropping pill machine, drop it into the condensate through the dropper, adjust the temperature control system of the dropping pill machine, and keep the dropper temperature of the dropping pill machine at 80±10°C , the temperature of the condensate is kept at 0±5°C, and the condensate is liquid paraffin or methyl silicone oil;

Step 4 Wipe the pills: Take out the pills, remove the condensed liquid on the surface, and dry to get the Su dropping pills.

Adopting the method cost of macroporous resin adsorption separation when the extract of Litectin Rhizoma is refined is low; It is HP-20, D101 or D201 macroporous resin, among which D101 type macroporous resin is the best.

In order to meet the clinical needs of the dried and shaped plain dropping pills, the conventional technology can be used to coat the sugar-coated layer or the film-coated layer to make the coated dripping pills.

Beneficial effects Yanhuanglian dripping pills involved in the present invention use polyethylene glycol as a water-soluble matrix, and the drug and the matrix can form a solid dispersion under quenching conditions after co-melting. The drug exists in the state of molecules or amorphous particles, which The water-based matrix polyethylene glycol has a wetting effect on the drug, which can quickly dissolve the drug into particles or solutions, thereby accelerating the dissolution and absorption of insoluble drugs, thereby improving the bioavailability and exerting high-efficiency and quick-acting effects; The production technology of the drop pill preparation, the production equipment are simple, the production cycle is short, the production efficiency is high, and the cost is low; the content of active ingredients in the extract of Litectin Rhizoma is high, and the dry product weight of Radix Rhizoma Rhizoma contains 55% ( W/W) or more, wherein the dehydrocarvetine in the total alkaloids of Litectin Rhizoma accounts for more than 10% (W/W) in dry product weight of Litectin Rhizoma, and the content of active ingredients in the dropping pill preparation is also higher, Each gram of drop pills contains 80-135 mg of total alkaloids of Litectin chinensis; each gram of drop pills contains 18-45 mg of dehydrocarvetine.

Description of drawings

Figure 1 The average drug-time curves of Yanhuanglian dripping pills and tablets in rats (n=6) In the figure, 1 is the drug-time curve of Yanhuanglian dripping pills, and 2 is the drug-time curve of Yanhuanglian tablets

The technical solutions and beneficial effects of the present invention are further described below in conjunction with examples and test examples, but are not limited by the examples.

Detailed ways

The preparation of embodiment 1 dropping pill

Step 1 Preparation of Licorice root extract: Take 1Kg of Licorice root medicinal material, reflux 3 times with 8L of 60% (V/V) ethanol for 1.5 hours each time, combine the extracts, recover ethanol under reduced pressure and concentrate to liquid medicine The volume is 5L, filtered, and the filtrate is used as the D101 macroporous resin sample solution, and then eluted with 3 times the column volume of 60% ethanol, the eluate is collected, concentrated, and dried to obtain 52 g of Litectin Rhizoma extract, which is analyzed by ultraviolet spectrophotometry The content of total alkaloids in Litectin was determined to be 62.5%, and the content of dehydrocarvetine was determined to be 17.8% by high performance liquid chromatography.

Step 2 Ingredients: Weigh 10g of Litectin Rhizoma extract and 50g of Polyethylene Glycol 4000 respectively, heat the Polyethylene Glycol 4000 in a water bath heating method until melted, then add Litectin Rhizoma Extract and stir evenly to obtain a mixture;

Step 3 Dropping: Add the mixed liquid into the dripping device of the dropping pill machine, drop it into the condensate through the dropper, adjust the temperature control system of the dropping pill machine, and keep the dropper temperature of the dropping pill machine at 80±10°C Around, the liquid paraffin is a condensate, and the temperature is kept at about 0±5°C;

Step 4 Wipe the pills: Take out the pills, remove the condensed liquid on the surface, and dry to get the Su dropping pills.

Results: The weight of the pills was 27±1mg, and each pill contained an average of 2.8mg of total alkaloids from Litectinus chinensis; each pill contained 0.80mg of dehydrocarvetine.

Example 2

Step 1 Preparation of Litectin extract: Take 1Kg of Litectin, reflux twice with 6L of 50% ethanol for 2 hours each time, combine the extracts, recover ethanol under reduced pressure and concentrate until the liquid is 5L, filter, Get the filtrate as the HP-20 macroporous resin sample solution, desorb and elute with 50% ethanol of 3 times the column volume, collect the eluate, concentrate, and dry to obtain 49g of Litectin Rhizoma extract, and use UV spectrophotometry to determine the amount of rock. The total alkali content of Coptidis Rhizome is 60.5%, and the content of dehydrocarvetine determined by HPLC is 15.9%.

Step 2 Ingredients: Weigh 10g of Litectinus rhizome extract, 20g of polyethylene glycol 4000 and 20g of polyethylene glycol 6000, and heat the polyethylene glycol 4000 and polyethylene glycol 6000 until melted by heating in a water bath Add the rock berberine extract and stir evenly to obtain a mixed solution;

Step 3 Dropping: Add the mixed liquid into the dripping device of the dropping pill machine, drop it into the condensate through the dropper, adjust the temperature control system of the dropping pill machine, and keep the dropper temperature of the dropping pill machine at 80±10°C Around, the liquid paraffin is a condensate, the temperature is kept at about 0±5°C, and the condensate is dripped;

Step 4 Wipe the pills: Take out the pills, remove the condensed liquid on the surface, and dry to get the Su dropping pills.

Results: The weight of the pills was 27±1mg, and the average content of total alkaloids in each pill was 3.5mg; each pill contained 0.92mg of dehydrocarvetine.

Example 3

Step 1 Preparation of Litectin extract: Take 1Kg of Litectin, reflux twice with 10L of 70% ethanol for 1 hour each time, combine the extracts, recover ethanol under reduced pressure and concentrate until the liquid is 5L, filter and take The supernatant was used as the D201 macroporous resin loading solution, eluted with 70% ethanol of 3 times the column volume, collected the eluate, concentrated, and dried to obtain 59.2g of Litectinum extract, which was determined by UV spectrophotometry for total alkaloids of Litectin The content is 55.5%, and the dehydrocarvetin content is 11.6% as determined by the high performance liquid phase method.

Step 2 Ingredients: Weigh 10g of Litectinus rhizome extract, 40g of polyethylene glycol 4000 and 10g of polyethylene glycol 6000, and heat the polyethylene glycol 4000 and polyethylene glycol 6000 until melted by heating in a water bath Add the rock berberine extract and stir evenly to obtain a mixed solution;

Step 3 Dropping: Add the mixed liquid into the dripping device of the dropping pill machine, drop it into the condensate through the dropper, adjust the temperature control system of the dropping pill machine, and keep the dropper temperature of the dropping pill machine at 80±10°C Around, the liquid paraffin is a condensate, the temperature is kept at about 0±5°C, and the mixture drops into the condensate;

Step 4 Wipe the pills: Take out the pills, remove the condensed liquid on the surface, and dry to get the Su dropping pills.

Results: The weight of the pills was 27±1mg, and each pill contained an average of 2.5mg of total alkaloids from Litectinus chinensis; each pill contained 0.52mg of dehydrocarvetine.

Experimental example 1 Orthogonal test method to optimize the extraction process of Litectin chinensis

Select the L ₉ (3 ⁴ ) orthogonal test table to optimize the extraction process conditions of Litectinus rhizome. The factors and levels are shown in Table 1-1. Weigh 50g of Litectin Rhizoma powder, according to the arrangement of orthogonal experiment, reflux extraction, filter, and measure the content of total alkaloids and dehydrocarvetin in each extract.

Table 1-1 Orthogonal test factor level table

test results

Taking total alkaloids and dehydrocarvetine as evaluation indicators, the method of comprehensive scoring is used for orthogonal process optimization, the yield of total alkaloids (mg/g) accounts for 50% of the weight, and the yield of dehydrocarvetine (mg/g) accounts for 50% of the weight, and the calculation formula is as follows: comprehensive score=yield of total alkaloids×50%+yield of dehydrocarvetin×50%. The results are shown in Table 1-2.

It can be seen from Table 1-2 that the optimal alcohol extraction process condition of Litectinus chinensis should be A ₂ B ₃ C ₂ D ₃ , that is, take the coarse powder of Litectinus rhizome and add 10 times the amount of 60% ethanol to reflux extraction for 3 times, each time 1.5 hours.

Because the amount of ethanol has little effect on the extraction effect, and from the perspective of cost reduction, 8 times the amount is more economical than 10 times the amount.

Table 1-2 Orthogonal experiment results

Conclusion: reflux with 6-10 times 60% ethanol for 1-3 times, each time for 1-2 hours, can obtain good extraction effect, and 8 times 60% ethanol for 3 times, each time for 1.5 hours is the best. good.

Test Example 2 Screening of the refining effect of different types of macroporous resins on the total alkaloids extract of Litectinum Rhizoma

Six types of macroporous resins were screened using the specific adsorption capacity and specific elution capacity as indicators.

Upper column solution: take 100g of Litectinus chinensis medicinal material, reflux 3 times with 800mL of 60% ethanol, each time for 1.5 hours, combine the extracts, recover ethanol under reduced pressure and concentrate until the volume of the medicinal solution is 500mL, take the supernatant after filtration, and use as Column solution.

The macroporous resin refines the total alkaloids extract of Litectinum Rhizoma: wet packing column (inner diameter 1cm × 6.4cm), the upper column solution is loaded with a flow rate of 2BV/h, and then eluted with 60% ethanol, and the eluate is collected. Set the volume to an appropriate volume, measure the content of total alkaloids and dehydrocarvetin in the eluent, calculate the specific adsorption capacity, specific elution capacity and elution rate (elution rate (%) = specific elution capacity/ratio Adsorption capacity × 100%), the results are shown in Table 2.

Table 2 Dynamic adsorption-elution performance of various resins

It can be seen that HP-20, D101, and DA201 resins all have higher specific adsorption capacity and elution rate for total alkaloids and dehydrocarvetin, among which D101 resin has the best comprehensive performance of adsorption and elution. Although HPD-100 has a high specific adsorption capacity, its elution rate is low.

Experimental example 3 Select different dropping pill bases to carry out the experiment of formulating

Experimental design: In order to increase the solubility of total alkaloids of Litectinus chinensis in dripping pills and improve bioavailability, water-soluble substrates were selected. Currently, the water-soluble substrates used in Chinese medicine dripping pills mainly include polyethylene glycol (PEG), polyoxyethylene 40. Sodium stearate, glycerin gelatin, etc. The matrix and the main drug cannot react and are harmless to the human body. In addition, the melting point is relatively low, easy to melt, and can be quickly solidified into a solid when quenched, and this property remains unchanged after adding the drug. Here, PEG with good dispersion and greater cohesion is mainly selected as the matrix.

Polyethylene glycol (Polyethyeneglycol, PEG) is a mixture of ethylene oxide or ethylene oxide and water addition polycondensation, molecular weight ranging from 200-25000. The proposed excipients are mainly PEG4000, PEG6000 or a mixture of the two in different proportions, and a blank matrix dropping pill is prepared for screening. The screening results are shown in Table 3.

Table 3 Dropping Pill Matrix Screening Results

It can be seen from Table 3 that PEG4000: PEG6000 can be used as a drop pill base in the range of 5-0: 0-5 in weight ratio, and the preferred weight ratio of PEG4000: PEG6000 is 4: 1 or 3: 2 or 1: 1 , especially the weight ratio of PEG4000:PEG6000 is 4:1 is the best.

Example 4 Dropping pills coated with sugar

(1) Prescription of sugar coating solution:

65% syrup 1ml

15% gelatin solution 0.2ml

Talc powder 2.4g

Sichuan wax 0.002g

(2) Sugar coating method: mix 1 ml of 65% syrup and 0.2 ml of 15% gelatin solution, and stir evenly to obtain gum syrup. Put the plain dropping pills of rhizoma rhizome obtained in Example 1 in the coating pan, and preheat to 35-40°C. First add 0.06ml of gum syrup, then add 0.24g of talcum powder, dry with hot air, after coating 3-4 layers, add 0.12ml of gum syrup, gradually reduce the talcum powder to a minimum of 0.1g, and only add gum syrup for the last time. Add talcum powder, and wrap 8-10 layers of icing in total. After the dropping pills are dried, stop the rotation of the coating pan, blow the cold wind to reduce the temperature of the dropping pills to room temperature, add 0.002g of Sichuan wax powder, and rotate the wax coating until the dropping pills are bright and smooth, and the wax coating is uniform. Each dropping pill is 29±1mg.

Example 5 Dropping Pills with Film Coating Example

(1) Prescription of film coating solution:

Hydroxypropyl methylcellulose 2g

Talc powder 2g

Titanium dioxide 0.2g

Glycerin 1ml

70% ethanol 100ml

(2) Coating method: add 2 g of hydroxypropyl methylcellulose to 100 mL of 70% ethanol, soak and dissolve, add talcum powder and titanium dioxide passed through a 100-mesh sieve, then add glycerin, stir well, and filter through a 100-mesh sieve , to obtain the coating solution. Shake the coating solution evenly before spraying. Put the plain dripping pills of Litectin chinensis obtained in Example 1 in a coating pan, preheat to 40°C, spray an appropriate amount of coating liquid, and dry them alternately with hot air and cold air at 40°C, and the rotating speed of the coating pan is 25-45 rpm , It can be rotated at low speed when spraying liquid, and high speed can be used when drying. Repeated spray drying until the weight of the dropping pills increases by 2% to 4%. After coating, dry in a desiccator for more than 24 hours to obtain the coated dropping pills.

Test Example 4 Orthogonal test to optimize prescription and dripping process

The preparation of Litectin Rhizoma extract and the process conditions of dropping pills are the same as in Example 1.

On the basis of the single factor investigation test results, an orthogonal design was carried out to screen the best technology and prescription for the preparation of dripping pills. The factors and levels are shown in Table 4-1. Taking the difficulty of dripping, the roundness, hardness, appearance, weight difference and dissolution time limit of the dropping pills as indicators, the scores are scored on a 5-point system, see Table 4-2. The formula for calculating the comprehensive score is: total score = a+b+c+d+e+f.

The results of the orthogonal experiment are shown in Table 4-3. It can be concluded that the optimal preparation process conditions of Yanhuanglian dripping pills should be A ₂ B ₁ C ₂ D ₃ , that is, the ratio of drug to matrix is 1:5, and the holding temperature is 70°C. The condensation temperature is 0°C, and the drop rate is 30 drops/min.

Table 4-1 Orthogonal test factor level table

Table 4-2 Grading Form

Table 4-3 Orthogonal experiment results

Test Example 5 The in vitro dissolution rate comparison of Yanhuanglian dripping pills and tablets

Dropping pill: get the sample of embodiment 1

Tablet: the preparation method is as follows: take the total alkaloids of Litectinus chinensis, starch and powdered sugar, mix and sieve twice with a 60-mesh sieve, add ethanol (45%) as a wetting agent and stir to make a soft material, and then pass through a 16-mesh sieve to granulate , dried at 60°C for 1 hour, the dry granules passed through a 16-mesh sieve, added 5% dry starch as a disintegrant and 0.5% magnesium stearate as a lubricant, mixed thoroughly and then pressed into tablets. The weight of the prepared tablet is 100 mg/tablet, wherein the total alkaloid content is 15 mg, and the dehydrocarvetine content is 4.8 mg.

Test Methods

Refer to the second appendix XC of "Chinese Pharmacopoeia" 2005 edition and choose the small cup method to carry out the experiment. The dissolution medium uses 250mL degassed 0.1N hydrochloric acid, the temperature is controlled at 37°C, and the rotation speed is 50r/min. The time is started as soon as the test product enters the release cell, and 4mL samples are taken at different time points (while adding isothermal and equal volume dissolution medium), Filter immediately with a 0.45 μm microporous membrane, and then measure the absorbance of the filtrate at 346 nm. Substitute into the regression equation to calculate the total alkaloid content of Litectinus chinensis, and calculate the cumulative dissolution percentage.

The test results are shown in Table 5

Table 5 Comparison of the dissolution rates of Yanhuanglian dripping pills and Yanhuanglian tablets

Conclusion: Compared with tablets, Yanhuanglian dripping pills have a faster dissolution rate and a higher cumulative dissolution amount.

Test Example 6 Pharmacokinetic study of Yanhuanglian dripping pills and tablets

Experimental materials: Yanhuanglian dripping pills and Yanhuanglian tablets, same as test example 5,

Yanhuanglian dripping pills and Yanhuanglian tablets were made into suspension aqueous solutions, and given to SD rats by intragastric administration at a dose of 20 mg/kg. At 0, 10, 20, 30, 60, 120, 180, 240, 300, 360, 480, 540 minutes after intragastric administration, blood was taken from the orbit, and after the plasma was separated, the dehydrogenation in the plasma sample was determined by HPLC-MS/MS method The content of Carvetine draws the plasma concentration-time curve (as shown in Figure 1) of dehydrocarvetine after oral administration respectively of drop pill or tablet, calculates pharmacokinetic parameter, the results are shown in Table 6.

The main pharmacokinetic parameters of table 6 Yanhuanglian dripping pills and tablets

Compared with Yanhuanglian tablet, ^* P＜0.05

The results show that the bioavailability of Yanhuanglian dripping pills is significantly improved compared with Yanhuanglian tablets, AUC _0-∞ can be nearly doubled, the highest blood concentration is 3.5 times that of tablets, and the peak time is from the tablet's 75min shortened to 50min.

Conclusion: Yanhuanglian dripping pills prepared by the present invention have the characteristics of high bioavailability and rapid drug release.

Claims (4)

1. a Yanhuanglian dripping pill, characterized in that: it is made from the raw materials of the following parts by weight Litectin extract 1 part 4-6 parts of polyethylene glycol The above-mentioned Litectin Rhizoma extract is obtained by extracting the Litectin Rhizoma medicinal material with 50-60% ethanol aqueous solution, recovering ethanol under reduced pressure, concentrating to a volume 5 times of the weight of the Litectin Rhizoma medicinal material, filtering the solution, Take the filtrate and absorb it with a macroporous resin, elute with 50-70% ethanol aqueous solution, concentrate and dry the eluent to obtain a dry product of the extract of Litectin, which contains more than 55% of the total alkaloids of Litectin, and the total alkaloids of Litectin The dehydrocarvetine accounts for more than 10% of the dry product weight of the rhizoma rhizome extract; The polyethylene glycol is a mixture of molecular weight 4000 and 6000, and the weight ratio of polyethylene glycol 4000: polyethylene glycol 6000 is 4:1 or 3:2 or 1:1; Described macroporous resin is HP-20, D101 or DA201 type macroporous resin; The Yanhuanglian dropping pills contain 80-135 mg of total alkaloids of Yanhuanglian and 18-45 mg of dehydrocarvetine in each gram of the dropping pills. 2. a preparation method of Yanhuanglian dripping pills, characterized in that it is carried out in the following steps: Step 1 Preparation of Litectin Rhizoma Extract: Take Litectin Rhizoma herb, reflux 1-3 times with 6-10 times 50-60% ethanol aqueous solution each time, 1-2 hours each time, combine extracts, recover ethanol under reduced pressure, Concentrate until the volume is 5 times of the weight of the raw material of Litectin Rhizoma, filter the solution, take the filtrate to absorb with macroporous resin, elute with 50-70% ethanol aqueous solution, collect the eluate, concentrate and dry to obtain the Litectin Rhizoma extract, Described macroporous resin is HP-20, D101 or DA201 type macroporous resin; Step 2 Ingredients: According to the weight ratio of Litectin Rhizoma: Polyethylene glycol weight ratio of 1:4-6, weigh the Litectin Rhizoma extract and polyethylene glycol respectively, first heat the polyethylene glycol to melt, and stir Add the extract of Litectin Radix, mix well to obtain a mixed solution, the polyethylene glycol is a mixture of molecular weight 4000 and 6000, and the weight ratio of polyethylene glycol 4000: polyethylene glycol 6000 is 4:1 or 3:2 or 1:1; Step 3 Dropping: Add the mixed liquid into the dripping device of the dropping pill machine, drop it into the condensate through the dripper, adjust the temperature control system of the dropping pill machine, and keep the temperature of the dripper at 80±10°C , the temperature of the condensate is kept at 0±5°C, and the condensate is liquid paraffin or methyl silicone oil; Step 4 Wipe the pills: Take out the pills, remove the condensed liquid on the surface, and dry to get the Su dropping pills. 3. The preparation method of Yanhuanglian dripping pills according to claim 2, characterized in that: the macroporous resin described in step 1 when preparing the Yanhuanglian extract is D101 type macroporous resin. 4. The preparation method of Yanhuanglian dripping pills according to claim 2 is characterized in that: the plain dripping pills after drying and shaping are then coated with sugar-coated or film-coated pills by conventional techniques to make coated dripped pills. the

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