CN101653131B - Bactericidal composition containing azoxystrobin - Google Patents
Bactericidal composition containing azoxystrobin Download PDFInfo
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- CN101653131B CN101653131B CN 200910161492 CN200910161492A CN101653131B CN 101653131 B CN101653131 B CN 101653131B CN 200910161492 CN200910161492 CN 200910161492 CN 200910161492 A CN200910161492 A CN 200910161492A CN 101653131 B CN101653131 B CN 101653131B
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- fluoxastrobin
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- bactericidal composition
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- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 16
- 239000005730 Azoxystrobin Substances 0.000 title abstract description 4
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition which contains effective ingredients of azoxystrobin and zhongshengmycin, wherein the mass ratio of the azoxystrobin to the zhongshengmycin is 50:1-1:5, and the weight percentage content of the two active ingredients in the composition is 1-80%. The composition can be used for preventing and treating diseases of cereal crops, fruit trees and vegetables, and has wide application range, low cost and good effect.
Description
Technical field
The present invention relates to a kind of bactericidal composition, relate in particular to a kind of combination sterilization composition that contains Fluoxastrobin.
Background technology
Fluoxastrobin (Azoxystrobin) is a kind of methoxy acrylic bactericide, and tool is protected, treated and root out triple function, has good crop safety and very outstanding Environmental compatibility.It is a kind of mitochondrial respiratory inhibitor.At present, Fluoxastrobin related preparations product mainly contains 25% Fluoxastrobin suspending agent, 325 grams per liter Difenoconazole Fluoxastrobin suspending agents, 500 grams per liter Fluoxastrobin tpn suspending agents etc., is mainly used in control vegetables, fruit diseases.The independent application of Fluoxastrobin makes germ produce serious resistance easily, carries out compositely through different cultivars, is the effective way of preventing and treating the pesticide resistance germ.Composite dose of present Fluoxastrobin is of less types, can not satisfy and produce the needs of going up control of crop disease.
Summary of the invention
The objective of the invention is for fear of the agent of long-term use Fluoxastrobin list, cause germ to be prone to produce resistance, the defective that use cost improves provides a kind of the control to compose wide, low, the effective combination sterilization composition of cost.
In view of single agent is difficult to satisfy on the agricultural severe diseases control needs day by day, the combination of active principles of different agricultural chemicals is carried out composite, be solve some problems in the agricultural chemicals list agent application process at present a kind of effectively with mode efficiently.
In order to realize the object of the invention, utilize existing pesticide species resource better, the inventor has carried out the test of a large amount of compound screenings, unexpectedly finds Fluoxastrobin and middle living rhzomorph is composite that fruit white rot of grape, anthracnose are had outstanding curative effect.
The middle rhzomorph of giving birth to is a kind of novel agricultural antibiotic that the Chinese Academy of Agricultural Sciences biological control research institute develops; Belong to N-glucosides class alkaline water soluble substance; Be the wider protective fungicide of a kind of fungicidal spectrum, have tag, osmosis, bacterial disease and the fungal disease of crops had very high activity; Have certain production-increasing function simultaneously, safe in utilization.The middle rhzomorph of giving birth to can suppress the synthetic of pathogen bacterium protein, and can make the filamentous fungi deformity, suppresses spore germination and killing spores.Fluoxastrobin can suppress mitochondrial respiratory, and both mechanisms of action are different fully, and both are composite can to root out the resistance germ more easily to the effect of germ multidigit point, delays the generation of germ resistance, also can doublely control bacterial disease simultaneously, enlarges fungicidal spectrum, and the fungi bacterium is logical to be killed.
The technical scheme of invention is:
A kind of bactericidal composition; It is characterized in that active component is Fluoxastrobin and middle living rhzomorph; Wherein the weight ratio of Fluoxastrobin and middle living rhzomorph is 50: 1～1: 5, and the total weight percentage of active component is 1～80% in the composition, and all the other are to allow in the agricultural chemicals to use and the acceptable composition.Pesticide sterilizing composite of the present invention can use known method preparation to be fit to any one formulation that agricultural is used, and reasonable formulation is wetting powder, suspending agent, aqueous emulsion, microemulsion, water dispersible granules.
The auxiliary agent that uses in the composition of the present invention comprises that solvent, dispersant, emulsifier, stabilizing agent, antifreezing agent, thickener etc. and other are of value to the known substance that active ingredient is stablized and drug effect is brought into play in preparation; All be the various compositions of using or allow use in the pesticidal preparations always; Do not have special qualification, concrete composition and consumption require to confirm through simple experiment according to prescription.
As a kind of improvement of bactericidal composition of the present invention, the weight ratio of active component Fluoxastrobin and middle living rhzomorph is preferably 20: 1～and 1: 1, the total weight percentage of active component is preferably 1～60% in the composition.
Bactericidal composition of the present invention is applicable to control cereal class, each planting fruit-trees, vegetable crop disease; Like wheat powdery mildew, rice blast and banded sclerotial blight, sclerotinia rot of colza, pepper anthracnose, balsam pear scab, fruit white rot of grape, bitter rot or anthracnose of grape, sigatoka, mango anthracnose, oranges and tangerines penicilliosis, powdery mildew of cucumber, early blight of tomato and late blight, particularly prevent and treat diseases such as fruit white rot of grape, bitter rot or anthracnose of grape.
Compared with prior art, beneficial effect of the present invention is: 1. being mixed has obvious synergistic effect, has improved control efficiency, compares with single agent, and the consumption of active ingredient obviously reduces in the compound drug, thereby has reduced cost and alleviated the pollution to environment; 2. composition is become to be grouped into by two kinds of mechanism of action different effective, helps overcoming and delaying the pesticide resistance of germ; 3. middle living rhzomorph has fungi, the effect of bacterium double play, and both are mixed and have enlarged fungicidal spectrum.
Embodiment
In order to make the object of the invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.The following stated is merely the present invention embodiment preferably, only in order to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of within spirit of the present invention and principle, being made, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with accompanying claims.
1, wetting powder embodiment
Pesticide activity component Fluoxastrobin and middle living rhzomorph, auxiliary agent, filler are mixed the mixed again wetting powder that gets behind comminution by gas stream in proportion.Capital equipment: mixer, airslide disintegrating mill.
Give birth to the rhzomorph wetting powder in the embodiment 1:51% Fluoxastrobin
93% Fluoxastrobin (active component) 53.76g
Give birth to rhzomorph (active component) 10g in 10%
Sodium lignin sulfonate (dispersant) 5g
The withered powder of tea (dispersant) 5g
Draw back powder (dispersant) 1g
White carbon (filler) 1g
Attapulgite (filler) 24.24g
Give birth to the rhzomorph wetting powder in the embodiment 2:28% Fluoxastrobin
93% Fluoxastrobin (active component) 26.88g
Give birth to rhzomorph (active component) 30g in 10%
Sodium lignin sulfonate (dispersant) 5g
The withered powder of tea (dispersant) 5g
Draw back powder (dispersant) 1g
White carbon (filler) 1g
Attapulgite (filler) 31.12g
2, suspending agent embodiment
Press formula rate, after Fluoxastrobin and middle living rhzomorph active component, surfactant, thickener, carrier or filler and the mixing of part water, through high speed shear, the wet method sand milling is processed semi-finished product, and moisturizing mixes filtration and promptly obtains finished product after analyzing.
Give birth to the rhzomorph suspending agent in the embodiment 3:6% Fluoxastrobin
93% Fluoxastrobin (active component) 1.08g
Give birth to rhzomorph (active component) 50g in 10%
Sodium lignin sulfonate (dispersant) 5g
Magnesiumaluminumsilicate (auxiliary material) 1g
Ethylene glycol (solvent) 5g
White carbon (filler) 1g
Water (filler) 31.12g
Give birth to the rhzomorph suspending agent in the embodiment 4:21% Fluoxastrobin
93% Fluoxastrobin (active component) 21.51g
Give birth to rhzomorph (active component) 10g in 10%
Sodium lignin sulfonate (dispersant) 5g
Magnesiumaluminumsilicate (auxiliary material) 1g
Ethylene glycol (solvent) 5g
White carbon (filler) 1g
Water (filler) 56.49g
3, the processing of microemulsion, aqueous emulsion and embodiment
By each set of dispense ratio, Fluoxastrobin is dissolved in the solvent, add surfactant, mix and make oil phase; With middle living rhzomorph and the mixed water that gets of water; Oil phase is added in aqueous phase or the water adding oil phase, the limit edged stirs, and makes microemulsion or aqueous emulsion again.
Give birth to the rhzomorph microemulsion in the embodiment 5:2% Fluoxastrobin
93% Fluoxastrobin (active component) 1.08g
Give birth to rhzomorph (active component) 10g in 10%
DMF (solvent) 10g
Xylol (solvent) 10g
Propane diols (antifreezing agent) 5g
Castor oil polyoxyethylene ether (emulsifier) 8g
Calcium dodecyl benzene sulfonate (wetting agent) 3g
Water 52.92g
Give birth to the rhzomorph aqueous emulsion in the embodiment 6:10% Fluoxastrobin
93% Fluoxastrobin (active component) 9.68g
Give birth to rhzomorph (active component) 10g in 10%
DMF (solvent) 5g
Xylol (solvent) 10g
Glycerine (antifreezing agent) 5g
Castor oil polyoxyethylene ether (emulsifier) 8g
Calcium dodecyl benzene sulfonate (wetting agent) 5g
Water 47.32g
4, water dispersible granules embodiment
Pesticide activity component Fluoxastrobin and middle living rhzomorph, auxiliary agent and filler are mixed in proportion,, add the water of 15-20% then, make the water dispersible granules product through kneading, granulation, drying, screening through comminution by gas stream.Capital equipment: mixer, airslide disintegrating mill, kneader, Squeezinggranulator, drying equipment (drying room or fluid bed).
Give birth to the rhzomorph water dispersible granules in the embodiment 7:31% Fluoxastrobin
93% Fluoxastrobin (active component) 32.26g
Give birth to rhzomorph (active component) 10g in 10%
Sodium lignin sulfonate (dispersant) 5g
Methyl naphthalene sulfonate formaldehyde condensate (diffusant) 15g
Lauryl sodium sulfate (wetting agent) 5g
Sodium alginate (adhesive) 5g
Potter's clay (filler) 27.74g
Biological activity determination embodiment: Fluoxastrobin and middle living rhzomorph are to the fruit white rot of grape Toxicity Determination
Subjects: the fruit white rot of grape bacterium (Coniothyrium diplodiella) of picking up from the field
Test method: adopt the mycelial growth rate method.The fruit white rot of grape bacterium is used the PDA medium culture, when treating that bacterium colony has just covered with culture dish, use internal diameter to punch from the edge as the card punch of 7mm, the mycelia piece that breaks into is as inoculum.Get the soup 5mL for preparing and quantitative 75mL sterilising medium respectively and mix, process 4 pastille flat boards, be mixed into contrast with equivalent sterile water and medium.The inversion of mycelia piece is connected to dull and stereotyped central authorities, and in 28 ℃ of incubators, cultivates.Measure colony diameter with the right-angled intersection method behind the 7d, calculate and respectively handle the clean amount of growth of mycelia, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-7
Mycelial growth inhibition rate (%)=[(the clean amount of growth of the clean amount of growth-processed group of control group)/clean amount of growth of control group] * 100
Mycelial growth inhibition rate is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, concentration EC in calculating the virulence equation and suppress with method of least squares
50, according to the toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ confession reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC>=120, then the composition performance is synergistic effect.
Result's (table 1) shows that Fluoxastrobin and middle living rhzomorph are between proportioning 50: 1～1: 5, and therefore co-toxicity coefficient has synergistic effect to fruit white rot of grape more than 120.
Table (1) Fluoxastrobin and the composite Toxicity Determination result of middle living rhzomorph to fruit white rot of grape
| Handle | EC 50(μg/mL) | ATI | TTI | Co-toxicity coefficient CTC |
| Fluoxastrobin | 16.27 | 100 | - | - |
| The middle rhzomorph of giving birth to | 58.74 | 27.70 | - | - |
| Fluoxastrobin 1: middle living rhzomorph 5 | 28.43 | 57.23 | 39.75 | 143.97 |
| Fluoxastrobin 1: middle living rhzomorph 1 | 16.32 | 99.69 | 63.85 | 156.14 |
| Fluoxastrobin 10: middle living rhzomorph 1 | 7.65 | 212.68 | 93.43 | 227.64 |
| Fluoxastrobin 20: middle living rhzomorph 1 | 8.21 | 198.17 | 96.56 | 205.24 |
| Fluoxastrobin 30: middle living rhzomorph 1 | 12.84 | 126.71 | 97.67 | 129.74 |
| Fluoxastrobin 50: middle living rhzomorph 1 | 12.63 | 128.82 | 98.58 | 130.67 |
Field efficacy application implementation example:
Fluoxastrobin and middle living rhzomorph series proportioning are prevented and treated fruit white rot of grape, anthracnose (Colletortrichumgloeosporiodes) field control effectiveness test.
1, test processing: this test medicine dosage is according to table (2), and the contrast medicament is respectively to give birth to rhzomorph wetting powder and 25% Fluoxastrobin suspending agent (Amici reaches) in the commercially available agricultural chemicals 3%, and blank is tested with clear water.
2, test method: the test region was total to dispenser 12 times in 10 days at grape the time of infertility at interval, promptly before blooming May 7, began to spray grape maturity on medicine to August 27.
3, investigation method: in test region and blank (CK) check plot, picked at random different parts fruit ear writes down total fruit grain number of each fruit ear and sick fruit grain number more than 50.
4, drug effect computational methods
5, result of the test
Table (2) Fluoxastrobin and middle living rhzomorph bactericidal composition are to the field trial of grape white rot, anthracnose
Can be seen by field control effectiveness test: Fluoxastrobin and the agent of middle living rhzomorph list are preventing and treating on fruit white rot of grape and the anthracnose, and preventive effect is the highest has only 73.39%, and minimum 41.83%; Bactericidal composition of the present invention increases significantly on preventive effect, and from above embodiment, minimum preventive effect is 89.47%; Be up to 95.96%; When particularly Fluoxastrobin and middle living rhzomorph ratio of quality and the number of copies were 20: 1～1: 1 (embodiment 2,4,5,6), preventive effect promoted particularly evident, has reached 93.83%～95.96% to fruit white rot of grape and anthracnose preventive effect; Therefore from field control effectiveness test, Fluoxastrobin and middle living rhzomorph be composite to have synergistic function.
Claims (5)
1. bactericidal composition, it is characterized in that: active component is Fluoxastrobin and middle living rhzomorph in the composition, and wherein the weight ratio of Fluoxastrobin and middle living rhzomorph is 50: 1～1: 5, and the weight percentage of two kinds of active components is 1～80% in the composition.
2. bactericidal composition according to claim 1 is characterized in that: the mass ratio of Fluoxastrobin and middle living rhzomorph is 20: 1～1: 1 in the composition, and the weight percentage of two kinds of active components is 1～60% in the composition.
3. bactericidal composition according to claim 1 and 2 is characterized in that: the formulation of said bactericidal composition is a kind of in wetting powder, suspending agent, aqueous emulsion, microemulsion, the water dispersible granules.
4. according to right 1 application of described bactericidal composition on control of crop disease.
5. the application of 4 described bactericidal compositions as requested is characterized in that: the multiple diseases that control cereal class, fruit tree and vegetables are taken place.
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| CN102067851B (en) * | 2011-01-20 | 2014-03-05 | 陕西美邦农药有限公司 | Antibacterial composition containing polyoxin and methoxyacrylate compound |
| CN105076241A (en) * | 2015-08-10 | 2015-11-25 | 谢绪叶 | A fungicide containing azoxystrobin and baicalin |
| CN106577705A (en) * | 2016-11-22 | 2017-04-26 | 恒大园林集团有限公司 | Compounded ecological pesticide and preparing method thereof |
| CN106665259A (en) * | 2017-01-12 | 2017-05-17 | 恒大园林集团有限公司 | Real estate garden maintenance and management method |
| CN106967656B (en) * | 2017-05-31 | 2020-04-28 | 衡水学院 | Bacillus licheniformis and application thereof |
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| CN1930991A (en) * | 2006-10-01 | 2007-03-21 | 黄高 | Re-compounded germicide containing Bucillus licheniformis |
| CN101176452A (en) * | 2007-12-19 | 2008-05-14 | 深圳诺普信农化股份有限公司 | Composition with building action containing middle living bacterium element and phenylate cyclazo |
| CN101176458A (en) * | 2007-12-19 | 2008-05-14 | 深圳诺普信农化股份有限公司 | Composition with building action and containing middle living bacterium element as well as cardendazim |
| CN101176455A (en) * | 2007-12-17 | 2008-05-14 | 东莞市瑞德丰生物科技有限公司 | Composition with building action containing middle living bacterium element and alkene morpholine |
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| CN1930991A (en) * | 2006-10-01 | 2007-03-21 | 黄高 | Re-compounded germicide containing Bucillus licheniformis |
| CN101176455A (en) * | 2007-12-17 | 2008-05-14 | 东莞市瑞德丰生物科技有限公司 | Composition with building action containing middle living bacterium element and alkene morpholine |
| CN101176452A (en) * | 2007-12-19 | 2008-05-14 | 深圳诺普信农化股份有限公司 | Composition with building action containing middle living bacterium element and phenylate cyclazo |
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