CN101584721A - Chinese traditional medicine antibiotic hemostatic plaster - Google Patents
Chinese traditional medicine antibiotic hemostatic plaster Download PDFInfo
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- CN101584721A CN101584721A CNA2009100319463A CN200910031946A CN101584721A CN 101584721 A CN101584721 A CN 101584721A CN A2009100319463 A CNA2009100319463 A CN A2009100319463A CN 200910031946 A CN200910031946 A CN 200910031946A CN 101584721 A CN101584721 A CN 101584721A
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- 230000000694 effects Effects 0.000 claims abstract description 24
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- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a chinese traditional medicine antibiotic hemostatic patch principally composed by a back lining layer, a medicine layer and a antisticking layer, the medicine layer is composed of medicine and substrate, wherein the medicine is composed of plant essential oil having antibacterial activity and chinese traditional medicine having hemostasia activity. The invention provided patch uses plant essential oil and hemostasia chinese traditional medicine as activity component, the plant essential oil has strong antibiotic action and simultaneity can conquer problem of multidrug resistance caused by western medicine antibacterial; the hemostasia chinese traditional medicine can exert the whole action advantage of multi-approach, multi-target, multi-link of chinese traditional medicine, and simultaneity avoides toxic side effect caused by western haemostatic medicine; the plant essential oil is natural percutaneous absorption enhancer that can promote percutaneous absorption of hemostasia chinese traditional medicine and enhance hemostasia activity; matching the plant essential oil and the hemostasia chinese traditional medicine reasonably, possessing advantages of fast effect, antibiotic, good hemostasia effect, small toxic side effect, and source of the raw material is wide which can be obtained cheaply, and the preparation method is simple.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation, particularly a kind of Chinese medicine antibiotic hemostatic plaster.
Background technology
Adhesive bandage is the external dressing that is used for the open surgical wound of small size; effect with quick-acting haemostatic powder, protection wound surface, prevention infection, promotion healing; have advantages such as easy to carry, that use is simple simultaneously, become a kind of surgical medicine the most frequently used in people's daily life.
At present, the adhesive bandage on the market is of a great variety, and characteristics are respectively arranged.Common have Flexibi fabric bandages, a Wound plaster of yannan Baiyao etc.Contain cationic surfactant class wide-spectrum bactericide benzalkonium chloride in the Flexibi fabric bandages, do not contain hemorrhage, only rely on the elastic fabric hemostasis by compression, antibacterial effect better and haemostatic effect is relatively poor.And contain YUNNAN BAIYAO in the Wound plaster of yannan Baiyao, and having the effect of removing stasis to stop bleeding, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling, haemostatic effect is better and antibacterial effect is relatively poor.
Therefore, develop a kind of have good antibiotic, haemostatic effect, safety non-toxic, adhesive bandage cheap and easy to get has good market prospect.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Chinese medicine antibiotic hemostatic plaster, have good antibiotic, haemostatic effect, and safety non-toxic, cheap and easy to get.
For reaching this purpose, the invention provides a kind of Chinese medicine antibiotic hemostatic plaster, mainly be made up of backing layer, drug storehouse layer and adherent layer, drug storehouse layer is made up of medicine and substrate, and described medicine is made up of plants essential oil with antibacterial activity and the Chinese medicine with styptic activity.
Further, described plants essential oil with antibacterial activity is the quintessence oil of one or more plants in Compositae, Rutaceae, Umbelliferae, Labiatae, Lauraceae, Magnoliaceae, Zingiberaceae, Myrtaceae, grass family and the Dipterocarpaceae;
Further, described Chinese medicine with styptic activity is YUNNAN BAIYAO or is in following medical material or its extract one or more: Radix Cirsii Japonici, Herba Cirsii, Radix Sanguisorbae, Rhizoma Imperatae, Flos Sophorae, Cacumen Platycladi, Radix Boehmeriae, Radix Notoginseng, Radix Rubiae, Pollen Typhae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Agrimoniae, Petiolus Trachycarpi, Folium Callicarpae Formosanae, Nodus Nelumbinis Rhizomatis, Folium Artemisiae Argyi, Rhizoma Zingiberis Preparatum, Crinis Carbonisatus and Herba Artemisiae Annuae;
Further, described plants essential oil with antibacterial activity is the Herba Artemisiae Annuae quintessence oil;
Further, described Chinese medicine with styptic activity is YUNNAN BAIYAO;
Further, the weight proportion of described YUNNAN BAIYAO and Herba Artemisiae Annuae quintessence oil is 1: 1～1: 10;
Further, described substrate comprises pressure sensitive adhesive.
Beneficial effect of the present invention is: Chinese medicine antibiotic hemostatic plaster of the present invention is an active component with plants essential oil with antibacterial activity and the Chinese medicine with styptic activity, the plants essential oil antibacterial action is strong, can overcome the problem that Western medicine antimicrobial drug such as antibiotic etc. easily produce multidrug resistance simultaneously; Hemostatic of traditional herb medicine can be brought into play the mass action advantage of Chinese medicine multipath, many target spots, too many levels, the toxic and side effects of avoiding the Western medicine hemorrhage to cause simultaneously; Plants essential oil has the Transdermal absorption facilitation, is natural percutaneous absorption promoter, can promote the Transdermal absorption of Hemostatic of traditional herb medicine, strengthens styptic activity; With plants essential oil and Hemostatic of traditional herb medicine reasonable compatibility, have characteristics such as rapid-action, antibiotic, that haemostatic effect is good, and side effect is little, and raw material sources are extensive, cheap and easy to get, preparation method is simple, and therefore, patch of the present invention has good market prospect.
The specific embodiment
Quintessence oil claims volatile oil again, be the class extracted flower, leaf, stem, root or the fruit from plant have aromatic odor, at normal temperatures can evaporable oily liquids general name.Quintessence oil distributes very wide in plant kingdom, and wherein the higher plant of essential oil content mainly concentrates on: Compositae is (as Flos Chrysanthemi, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Herba Artemisiae Scopariae, Folium Artemisiae Argyi, Herba Artemisiae Annuae etc.), Rutaceae is (as Pericarpium Citri Reticulatae, Pericarpium Citri junoris, Fructus Aurantii Immaturus, Pericarpium Zanthoxyli, Fructus Evodiae, Fructus Citri etc.), Umbelliferae is (as Radix Angelicae Sinensis, Fructus Foeniculi, Rhizoma Chuanxiong, GAOMU, Fructus Cnidii, Resina Ferulae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae etc.), Labiatae is (as Herba Menthae, Herba Menthae Rotundifoliae, Folium Perillae, Herba Pogostemonis, Herba Schizonepetae, Herba Moslae etc.), Lauraceae is (as Cortex Cinnamomi, Ramulus Cinnamomi, Lignum cinnamomi camphorae, Fructus Litseae, Cinnamomum japonica etc.), Magnoliaceae is (as Cortex Magnoliae Officinalis, Flos Magnoliae, Fructus Schisandrae Chinensis, Fructus Anisi Stellati etc.), Zingiberaceae is (as Fructus Amomi, Fructus Amomi Rotundus, Semen Alpiniae Katsumadai, Fructus Tsaoko, Rhizoma Curcumae, Rhizoma Zingiberis Recens, Rhizoma Curcumae Longae, Rhizoma Alpiniae Officinarum, Fructus Alpiniae Oxyphyllae etc.), Myrtaceae is (as Folium eucalypti globueli (Eucalyptus globulus Labill.), Flos Caryophylli etc.), grass family is (as Herba Cymbopogonis Citrari, Herba Cymbopogonis etc.) and Dipterocarpaceae.Quintessence oil is the mixture that is grouped into by multiple one-tenth, is mainly terpenoid and aromatic compound and their containing oxygen derivative as alcohol, aldehyde, ketone, phenol, ether, lactone etc., comprises nitrogenous and sulfur-containing compound in addition.Modern study shows: quintessence oil has significant biological activity, as antibiotic, antiviral, antiinflammatory, reinforcement skin to the resistance of foreign aggression, promote cell metabolism and cell regeneration, help wound healing and cicatrix reparation, promote toxin discharge etc.; Simultaneously, the molecule of quintessence oil is little, and the penetration height has the Transdermal absorption facilitation, is natural Percutaneous absorption enhancer.Extracts essential oil can adopt steam distillation and organic solvent extractionprocess etc.
Hemostatic of traditional herb medicine is different according to the property of medicine and effect, is divided into blood-cooling hemostatic, stasis-resolving hemostatic, astringent hemostatic and meridian-warming hemostatic four classes, when using, can select suitable medicine according to hemorrhage reason and different pattern of syndrome.Hemostatic of traditional herb medicine commonly used has Radix Cirsii Japonici, Herba Cirsii, Radix Sanguisorbae, Rhizoma Imperatae, Flos Sophorae, Cacumen Platycladi, Radix Boehmeriae, Radix Notoginseng, Radix Rubiae, Pollen Typhae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Agrimoniae, Petiolus Trachycarpi, Folium Callicarpae Formosanae, Nodus Nelumbinis Rhizomatis, Folium Artemisiae Argyi, Rhizoma Zingiberis Preparatum, Crinis Carbonisatus and Herba Artemisiae Annuae etc.
In order to make the purpose, technical solutions and advantages of the present invention clearer, below the preferred embodiments of the present invention are described in detail.
Embodiment 1, Chinese medicine antibiotic hemostatic plaster
The Chinese medicine antibiotic hemostatic plaster of present embodiment, its preparation method may further comprise the steps:
The preparation of a, Herba Artemisiae Annuae quintessence oil: Herba Artemisiae Annuae is cut into the segment that length is 3～5cm, extracts quintessence oil with steam distillation, add the water of 8 times of amounts of medical material, heating decocted 3 hours, collect quintessence oil, use anhydrous sodium sulfate drying, filter, collect filtrate, get the Herba Artemisiae Annuae quintessence oil, standby;
The preparation of b, YUNNAN BAIYAO solution: YUNNAN BAIYAOFEN is made solution with deionized water dissolving, standby;
The preparation of c, substrate: with polyvinyl alcohol and polyvinylpyrrolidone respectively water swelling post-heating make dissolving, mix homogeneously adds polyacrylate pressure-sensitive, heated and stirred makes dissolving fully, substrate, standby;
The preparation of d, patch: substrate is heated above 10～15 ℃ of its fusing points, and adding YUNNAN BAIYAO solution to final concentration is 5mg/mL, stirs, be cooled to 60 ℃, adding Herba Artemisiae Annuae quintessence oil to final concentration is 50mg/mL, stirs, ultrasonic eliminating bubble, on coating machine it is coated adherent layer routinely then, the limit is coated with selvedge oven dry (60 ℃ of oven dry of temperature), and the reuse backing layer covers and be transferred to backing layer, promptly get the Chinese medicine antibiotic hemostatic plaster, cut into single dose by area, packing, promptly.
The preparation of embodiment 2, Chinese medicine antibiotic hemostatic plaster
The Chinese medicine antibiotic hemostatic plaster of present embodiment, its preparation method may further comprise the steps:
The preparation of a, Herba Artemisiae Annuae quintessence oil: Herba Artemisiae Annuae is cut into the segment that length is 3～5cm, extracts quintessence oil with steam distillation, add the water of 8 times of amounts of medical material, heating decocted 180 minutes, collect quintessence oil, use anhydrous sodium sulfate drying, filter, collect filtrate, get the Herba Artemisiae Annuae quintessence oil, standby;
The preparation of b, YUNNAN BAIYAO solution: YUNNAN BAIYAOFEN is made solution with deionized water dissolving, standby;
The preparation of c, substrate: carbomer water swelling post-heating is made dissolving, as the A phase; Sodium polyacrylate and Kaolin are dissolved in an amount of glycerol, as the B phase; Aluminum chloride and citric acid are dissolved in the suitable quantity of water, as the C phase; With B mutually and C mix homogeneously mutually, add the A phase again, fully stir, must substrate, standby;
The preparation of d, patch: substrate is heated above 10～15 ℃ of its fusing points, and adding YUNNAN BAIYAO solution to final concentration is 50mg/mL, stirs, be cooled to 60 ℃, adding Herba Artemisiae Annuae quintessence oil to final concentration is 50mg/mL, stirs, ultrasonic eliminating bubble, on coating machine it is coated adherent layer routinely then, the limit is coated with selvedge oven dry (60 ℃ of oven dry of temperature), and the reuse backing layer covers and be transferred to backing layer, promptly get the Chinese medicine antibiotic hemostatic plaster, cut into single dose by area, packing, promptly.
Antibiotic, haemostatic effect to Chinese medicine antibiotic hemostatic plaster of the present invention is described in detail below.
Get mouse part skin, keratodermatitis is made progress, sprawl on improvement Franz diffusion cell, be affixed on the mouse skin behind the Chinese medicine antibiotic hemostatic plaster removal adherent layer with the embodiment of the invention 1 or 2 preparations, fixture, in receiving chamber, add and receive liquid (mass percentage concentration is 10% aqueous acetone solution) and liquid level is just contacted with skin inner layer, regulating bath temperature is 37 ℃, mixing speed is 100r/min, collect after 24 hours and receive liquid, with the aperture is the filtering with microporous membrane of 0.45 μ m, and filtrate is concentrated into certain volume, standby; Positive controls (Wound plaster of yannan Baiyao) and blank group (mass percentage concentration is 10% aqueous acetone solution) are set simultaneously.
1, antibacterial activity detects (paper disk method)
Cut-off directly is the sterilization filter paper of 6.00mm, soaks 40 minutes in the concentrated filtrate of patch of the present invention, positive controls or blank group, gets drug sensitive test paper, and is standby; With cell density is 10
5The bacterium liquid of cfu/mL evenly is applied on the agar plate, treat that bacterium liquid is done after, 3 of overlapping thereon placement drug sensitive test papers, temperature is cultivated the sizes of measuring inhibition zone after 24 hours for 37 ℃.
The results are shown in Table 1, patch of the present invention has good bacteriostatic activity to escherichia coli, staphylococcus aureus and pseudomonas aeruginosa.
Table 1, antibacterial activity testing result
2, styptic activity detects
Japan large ear rabbit venous blood and sodium citrate anticoagulant were mixed in 9: 1 by volume, and centrifugal 15 minutes of 3000r/min gets blood plasma to be measured; Get blood plasma 0.1mL to be measured, add the concentrated filtrate 0.1mL of patch of the present invention, positive controls or blank group and the calcium chloride solution 0.1mL that concentration is 0.25M, measure blood plasma recalcification time (PRT).
The results are shown in Table 2, compare with positive controls, the styptic activity of patch of the present invention is stronger, shows that plants essential oil can promote the Transdermal absorption of Hemostatic of traditional herb medicine, strengthens styptic activity.
Table 2, styptic activity testing result
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although by invention has been described with reference to the preferred embodiments of the present invention, but those of ordinary skill in the art is to be understood that, can make various changes to it in the form and details, and the spirit and scope of the present invention that do not depart from appended claims and limited.
Claims (7)
1, Chinese medicine antibiotic hemostatic plaster mainly is made up of backing layer, drug storehouse layer and adherent layer, and drug storehouse layer is made up of medicine and substrate, it is characterized in that: described medicine is made up of plants essential oil with antibacterial activity and the Chinese medicine with styptic activity.
2, Chinese medicine antibiotic hemostatic plaster according to claim 1 is characterized in that: described plants essential oil with antibacterial activity is the quintessence oil of one or more plants in Compositae, Rutaceae, Umbelliferae, Labiatae, Lauraceae, Magnoliaceae, Zingiberaceae, Myrtaceae, grass family and the Dipterocarpaceae.
3, Chinese medicine antibiotic hemostatic plaster according to claim 1 is characterized in that: described Chinese medicine with styptic activity is YUNNAN BAIYAO or is in following medical material or its extract one or more: Radix Cirsii Japonici, Herba Cirsii, Radix Sanguisorbae, Rhizoma Imperatae, Flos Sophorae, Cacumen Platycladi, Radix Boehmeriae, Radix Notoginseng, Radix Rubiae, Pollen Typhae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Agrimoniae, Petiolus Trachycarpi, Folium Callicarpae Formosanae, Nodus Nelumbinis Rhizomatis, Folium Artemisiae Argyi, Rhizoma Zingiberis Preparatum, Crinis Carbonisatus and Herba Artemisiae Annuae.
4, according to the described Chinese medicine antibiotic hemostatic plaster of the arbitrary claim of claim 1 to 3, it is characterized in that: described plants essential oil with antibacterial activity is the Herba Artemisiae Annuae quintessence oil.
5, Chinese medicine antibiotic hemostatic plaster according to claim 4 is characterized in that: described Chinese medicine with styptic activity is YUNNAN BAIYAO.
6, Chinese medicine antibiotic hemostatic plaster according to claim 5 is characterized in that: the weight proportion of described YUNNAN BAIYAO and Herba Artemisiae Annuae quintessence oil is 1: 1～1: 10.
7, Chinese medicine antibiotic hemostatic plaster according to claim 6, it is characterized in that: described substrate comprises pressure sensitive adhesive.
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| CNA2009100319463A CN101584721A (en) | 2009-07-06 | 2009-07-06 | Chinese traditional medicine antibiotic hemostatic plaster |
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| CNA2009100319463A CN101584721A (en) | 2009-07-06 | 2009-07-06 | Chinese traditional medicine antibiotic hemostatic plaster |
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| CNA2009100319463A Pending CN101584721A (en) | 2009-07-06 | 2009-07-06 | Chinese traditional medicine antibiotic hemostatic plaster |
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| CN106943537B (en) * | 2017-02-28 | 2021-01-26 | 上海清轩生物科技有限公司 | Antibacterial composition and moisturizing repair composition containing camellia seed oil |
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