CN101530553A - Pharmaceutical composition with effects of tranquilizing and allaying excitement and preparation method thereof - Google Patents
Pharmaceutical composition with effects of tranquilizing and allaying excitement and preparation method thereof Download PDFInfo
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- CN101530553A CN101530553A CN200810101873A CN200810101873A CN101530553A CN 101530553 A CN101530553 A CN 101530553A CN 200810101873 A CN200810101873 A CN 200810101873A CN 200810101873 A CN200810101873 A CN 200810101873A CN 101530553 A CN101530553 A CN 101530553A
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- 230000000694 effects Effects 0.000 title claims abstract description 13
- 230000002936 tranquilizing effect Effects 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title abstract description 15
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 241001522129 Pinellia Species 0.000 claims abstract description 8
- 239000008187 granular material Substances 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 4
- 238000009472 formulation Methods 0.000 claims abstract 2
- 239000003826 tablet Substances 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 35
- 239000000843 powder Substances 0.000 claims description 20
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 8
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 2
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- 239000004615 ingredient Substances 0.000 claims description 2
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- 238000000605 extraction Methods 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 239000001645 levisticum officinale Substances 0.000 abstract 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a pharmaceutical composition with the effects of tranquilizing and allaying excitement and a preparation method thereof, the traditional Chinese medicine composition is prepared by the following pharmaceutical raw materials according to the mix ratio by weight: 100-300 parts of heterophylly falsestarwort root, 100-300 parts of prepared thinleaf milkwort root-bark[honey-fried radix polygalae], 100-300 parts of Chinese magnoliavine fruit, 100-300 parts of spina date seed, 100-300 parts of Szechuan lovage rhizome, 100-300 parts of eucommia bark, 100-200 parts of Chinese angelica, 100-200 parts of Indian buead, 100-200 parts of caulis polygoni multiflori, 100-200 parts of liquoric[liquorice] root, 100-200 parts of dwarf lilyturf tuber, 100-200 parts of cochinchnese asparagus root and 100-150 parts of pinellia tuber, and the traditional Chinese medicine composition is processed into any one formulation of clinically acceptable tablets, capsules, granules and the like by extraction, refining and other processes. The traditional Chinese medicine composition has the effects of tranquilizing, allaying excitement, benefiting essence and energy and strengthening bones and muscles, thereby being applicable to the symptoms of palpitation, insomnia, forgetfulness, dizziness, mental fatigue, loss of appetite and so on. The traditional Chinese medicine composition is currently mostly used for treating neurasthenia and other symptoms.
Description
Technical field:
The invention belongs to Chinese medicine capsule preparation technique field, be specifically related to treat a kind of drug regimen and preparation method thereof with effects of tranquilizing and allaying excitement.
Technical background
The insomnia refers to dyskoimesis, is modal sleep disorder, symptom as feel fatigue, agitation, emotional maladjustment, absent minded and poor memory etc., usually show as and can not fall asleep, the shakiness of sleeping, early awakening and wake up after can not refresh.Insomnia's the cause of disease is varied, can be caused by spirit, psychology and body illness, and difficulty falling asleep or initial aypnia are past habitually in the past with dysthymic disorders such as anxiety, fear or depressions.
Time of about in life 1/3 of people is spent in sleep, and sleep is with physically and mentally healthy closely related.Along with the quickening of social life rhythm, the increase of work, survival pressure, insomnia has become the No.1 formidable enemy who influences health.According to statistics, the puzzlement that the whole world has nearly 1/4 people to be had a sleepless night, according to the result of whole world sleep investigation, the incidence rate of China's insomnia is up to 45.4%, and recognizes and ownly suffer from the crowd who has a sleepless night and have only 25.9%.
Insomnia comprises mainly that too short, the difficulty falling asleep length of one's sleep, sleep degree are shallow, early awakening, frequent nightmare etc.Clinically insomnia is divided into acute and chronic two kinds, being less than for 3 weeks is acute insomnia, and surpassing for 3 weeks is chronic insomnia.Insomnia can cause have a dizzy spell, shortness of breath and palpitation, fatigue and asthenia, anorexia, multiple symptom such as absent minded, forgetful; If long-time insomnia causes easily that then immunity of organisms descends, the neuroendocrine imbalance; Prolongation along with the insomnia process also easily causes diseases such as heart disease, gastrointestinal disease, hypertension, depression, anxiety neurosis, more can cause hallucination and mind confusion etc. when serious.
Patients with chronic insomnia is called the chronicity insomnia again, and patient's classical symptom is tossed about exactly and had difficulty in going to sleep, dreaming often and waking easily, be difficult to after waking up once more sleeping, and daytime lassitude, dizziness headache, forgetful, when these symptoms continue just to have suffered from patients with chronic insomnia certainly more than one month at least.Part chronic insomnia patient is by transient insomnia continuity, and other are because due to the somatization anxiety state, as worried, uneasy, excessively watch out for, consider repeatedly etc.Patients with chronic insomnia is healthy formidable enemy, and high-quality sleep is most important to our physical and mental health, and chronic insomnia person's ability to work and work efficiency often reduce, and quality of life descends thereupon.Simultaneously, patient's sleepy more just has difficulty in going to sleep more, becomes all the more to the undue care and worried of having a sleepless night, so increase the weight of its symptom, forms vicious cycle.
Mostly the Western medicine of Cure for insomnia is some calmness, the spiritual class medicine of sleeping peacefully at present, if some untoward reaction can appear in improper use, takes for a long time also and can produce dependency and drug resistance.This disease of Chinese traditional treatment is taked determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, organic conception, has overcome above-mentioned drawback, has obtained excellent curative.Chinese medicine thinks that insomnia i.e. " being insomnia ", how by damaged by excess of seven emotions, ponders over due to overstrain or the being terrified suddenly, also has due to innate deficiency, the body deficiency due to old age.Its pathogenesis is that negative and positive of qi and blood is become estranged, visceral dysfunction, so that the mind disturbed, mental derangement and must not sleeping.The traditional Chinese medical science is in line with the principle of " treatment of disease must aim at its pathogenesis ", dispeling on the basis of the cause of disease, and according to patient's individual variation, diagnosis and prescription, conditioning viscera function in all directions reaches the purpose of thorough recovery from illness.
Summary of the invention:
One of purpose of the present invention provides a kind of drug regimen with effects of tranquilizing and allaying excitement and preparation method thereof.
Another purpose of the present invention provides the preparation method of this Chinese medicine composition.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription (in weight portion)
100-300 parts of 100-300 parts of Fructus Schisandrae Chinensis of 100-300 parts of Cortex et Radix Polygalae (processed) of Radix Pseudostellariae
100-300 parts of 100-300 parts of Cortexs Eucommiae of 100-300 parts of Rhizoma Chuanxiongs of Semen Ziziphi Spinosae
100-200 parts of 100-200 parts of Caulis Polygoni Multiflori of 100-200 parts of Poria of Radix Angelicae Sinensis
100-200 parts of 100-200 parts of Radix Asparagi of 100-200 parts of Radix Ophiopogonis of Radix Glycyrrhizae
100-150 parts of the Rhizoma Pinelliaes
The active component that preferred following raw materials according is made, curative effect is better:
200 parts of 200 parts of Fructus Schisandrae Chinensis of 200 parts of Cortex et Radix Polygalae (processed) of Radix Pseudostellariae
200 parts of 180 parts of Cortexs Eucommiae of 180 parts of Rhizoma Chuanxiongs of Semen Ziziphi Spinosae
120 parts of 150 parts of Caulis Polygoni Multiflori of 100 parts of Poria of Radix Angelicae Sinensis
100 parts of 100 parts of Radix Asparagi of 100 parts of Radix Ophiopogonis of Radix Glycyrrhizae
100 parts of the Rhizoma Pinelliaes
2. preparation technology
(1) getting Radix Angelicae Sinensis powder, to be broken into fine powder standby;
(2) Radix Pseudostellariae, Cortex et Radix Polygalae (processed), Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, the Cortex Eucommiae, Poria, Caulis Polygoni Multiflori, Radix Glycyrrhizae, Radix Ophiopogonis, Radix Asparagi, the Rhizoma Pinelliae are added 8 times of water gagings and decoct 2 times, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is condensed into clear paste; Add ethanol and make and contain alcohol amount and reach 70% (V/V) in clear paste, cold preservation 12 hours filters the filtered solution decompression recycling ethanol; To be concentrated into relative density under the temperature 60 be 1.12-1.20 clear paste with reclaiming concentrated solution behind the ethanol;
(3) with step (2) gained clear paste and step (1) gained fine powder mixing, drying is ground into dry powder, mixes with the conventional adjunct ingredient of medicine acceptable, can obtain corresponding different concrete dosage form.
Adopt above-mentioned Chinese medicine and preparation method thereof, distinctive active constituents of medicine among the present invention, full side has tranquillizing and allaying excitement, and the effect of beneficial vital essence, bone and muscle strengthening is applicable to diseases such as palpitation and insomnia, forgetful dizziness, spiritlessness and weakness, inappetence.Now be used for the treatment of the neurasthenia more and wait disease.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
200 parts of 200 parts of Fructus Schisandrae Chinensis of 200 parts of Cortex et Radix Polygalae (processed) of Radix Pseudostellariae
200 parts of 180 parts of Cortexs Eucommiae of 180 parts of Rhizoma Chuanxiongs of Semen Ziziphi Spinosae
120 parts of 150 parts of Caulis Polygoni Multiflori of 100 parts of Poria of Radix Angelicae Sinensis
100 parts of 100 parts of Radix Asparagi of 100 parts of Radix Ophiopogonis of Radix Glycyrrhizae
100 parts of the Rhizoma Pinelliaes
2. preparation technology
(1) getting Radix Angelicae Sinensis powder, to be broken into fine powder standby;
(2) Radix Pseudostellariae, Cortex et Radix Polygalae (processed), Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, the Cortex Eucommiae, Poria, Caulis Polygoni Multiflori, Radix Glycyrrhizae, Radix Ophiopogonis, Radix Asparagi, the Rhizoma Pinelliae are added 8 times of water gagings and decoct 2 times, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is condensed into clear paste; Add ethanol and make and contain alcohol amount and reach 70% (V/V) in clear paste, cold preservation 12 hours filters the filtered solution decompression recycling ethanol; To be concentrated into relative density under the temperature 60 be 1.12-1.20 clear paste with reclaiming concentrated solution behind the ethanol;
(3) with step (2) gained clear paste and step (1) gained fine powder mixing, drying is ground into dry powder, adds acceptable accessories, granulates, promptly.
Embodiment 2: the preparation method of tablet
200 parts of 200 parts of Fructus Schisandrae Chinensis of 200 parts of Cortex et Radix Polygalae (processed) of Radix Pseudostellariae
200 parts of 180 parts of Cortexs Eucommiae of 180 parts of Rhizoma Chuanxiongs of Semen Ziziphi Spinosae
120 parts of 150 parts of Caulis Polygoni Multiflori of 100 parts of Poria of Radix Angelicae Sinensis
100 parts of 100 parts of Radix Asparagi of 100 parts of Radix Ophiopogonis of Radix Glycyrrhizae
100 parts of the Rhizoma Pinelliaes
2. preparation technology
(1) getting Radix Angelicae Sinensis powder, to be broken into fine powder standby;
(2) Radix Pseudostellariae, Cortex et Radix Polygalae (processed), Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, the Cortex Eucommiae, Poria, Caulis Polygoni Multiflori, Radix Glycyrrhizae, Radix Ophiopogonis, Radix Asparagi, the Rhizoma Pinelliae are added 8 times of water gagings and decoct 2 times, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is condensed into clear paste; Add ethanol and make and contain alcohol amount and reach 70% (V/V) in clear paste, cold preservation 12 hours filters the filtered solution decompression recycling ethanol; To be concentrated into relative density under the temperature 60 be 1.12-1.20 clear paste with reclaiming concentrated solution behind the ethanol;
(3) with step (2) gained clear paste and step (1) gained fine powder mixing, drying is ground into dry powder, adds acceptable accessories, mixing, and tabletting, promptly.
Embodiment 3: the preparation method of capsule
200 parts of 200 parts of Fructus Schisandrae Chinensis of 200 parts of Cortex et Radix Polygalae (processed) of Radix Pseudostellariae
200 parts of 180 parts of Cortexs Eucommiae of 180 parts of Rhizoma Chuanxiongs of Semen Ziziphi Spinosae
120 parts of 150 parts of Caulis Polygoni Multiflori of 100 parts of Poria of Radix Angelicae Sinensis
100 parts of 100 parts of Radix Asparagi of 100 parts of Radix Ophiopogonis of Radix Glycyrrhizae
100 parts of the Rhizoma Pinelliaes
2. preparation technology
(1) getting Radix Angelicae Sinensis powder, to be broken into fine powder standby;
(2) Radix Pseudostellariae, Cortex et Radix Polygalae (processed), Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, the Cortex Eucommiae, Poria, Caulis Polygoni Multiflori, Radix Glycyrrhizae, Radix Ophiopogonis, Radix Asparagi, the Rhizoma Pinelliae are added 8 times of water gagings and decoct 2 times, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is condensed into clear paste; Add ethanol and make and contain alcohol amount and reach 70% (V/V) in clear paste, cold preservation 12 hours filters the filtered solution decompression recycling ethanol; To be concentrated into relative density under the temperature 60 be 1.12-1.20 clear paste with reclaiming concentrated solution behind the ethanol;
(3) with step (2) gained clear paste and step (1) gained fine powder mixing, drying is ground into dry powder, makes granule, incapsulates, promptly.
Claims (5)
1, a kind of drug regimen with effects of tranquilizing and allaying excitement is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
100-300 parts of 100-300 parts of Fructus Schisandrae Chinensis of 100-300 parts of Cortex et Radix Polygalae (processed) of Radix Pseudostellariae
100-300 parts of 100-300 parts of Cortexs Eucommiae of 100-300 parts of Rhizoma Chuanxiongs of Semen Ziziphi Spinosae
100-200 parts of 100-200 parts of Caulis Polygoni Multiflori of 100-200 parts of Poria of Radix Angelicae Sinensis
100-200 parts of 100-200 parts of Radix Asparagi of 100-200 parts of Radix Ophiopogonis of Radix Glycyrrhizae
100-150 parts of the Rhizoma Pinelliaes.
2, a kind of drug regimen with effects of tranquilizing and allaying excitement according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
200 parts of 200 parts of Fructus Schisandrae Chinensis of 200 parts of Cortex et Radix Polygalae (processed) of Radix Pseudostellariae
200 parts of 180 parts of Cortexs Eucommiae of 180 parts of Rhizoma Chuanxiongs of Semen Ziziphi Spinosae
120 parts of 150 parts of Caulis Polygoni Multiflori of 100 parts of Poria of Radix Angelicae Sinensis
100 parts of 100 parts of Radix Asparagi of 100 parts of Radix Ophiopogonis of Radix Glycyrrhizae
100 parts of the Rhizoma Pinelliaes.
3, according to the described a kind of drug regimen of claim 1-2, it is characterized in that adopting following method to make with effects of tranquilizing and allaying excitement:
(1) getting Radix Angelicae Sinensis powder, to be broken into fine powder standby;
(2) Radix Pseudostellariae, Cortex et Radix Polygalae (processed), Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, the Cortex Eucommiae, Poria, Caulis Polygoni Multiflori, Radix Glycyrrhizae, Radix Ophiopogonis, Radix Asparagi, the Rhizoma Pinelliae are added 8 times of water gagings and decoct 2 times, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is condensed into clear paste; Add ethanol and make and contain alcohol amount and reach 70% (V/V) in clear paste, cold preservation 12 hours filters the filtered solution decompression recycling ethanol; To be concentrated into relative density under the temperature 60 be 1.12-1.20 clear paste with reclaiming concentrated solution behind the ethanol;
(3) with step (2) gained clear paste and step (1) gained fine powder mixing, drying is ground into dry powder, mixes with the conventional adjunct ingredient of medicine acceptable, can obtain corresponding different concrete dosage form.
4, according to any one described a kind of drug regimen among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations with effects of tranquilizing and allaying excitement.
5, according to the described a kind of drug regimen of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet with effects of tranquilizing and allaying excitement.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600355A (en) * | 2012-04-07 | 2012-07-25 | 周国生 | Traditional Chinese medicine for treatment of syndrome of tension in examination |
| CN103479991A (en) * | 2013-10-14 | 2014-01-01 | 张桂赫 | Traditional Chinese medicine pill for treating dysphoria and sleeplessness and preparation method of pill |
| CN104547365A (en) * | 2014-12-24 | 2015-04-29 | 武海波 | Nerve-soothing traditional Chinese medicinal composition |
| CN105148232A (en) * | 2015-09-24 | 2015-12-16 | 张秀婵 | Traditional Chinese medicine composition used for treating amnesia |
| CN107362272A (en) * | 2017-08-31 | 2017-11-21 | 江西金顶药业有限公司 | A kind of Yangxue Anshen Syrup |
-
2008
- 2008-03-13 CN CN200810101873A patent/CN101530553A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600355A (en) * | 2012-04-07 | 2012-07-25 | 周国生 | Traditional Chinese medicine for treatment of syndrome of tension in examination |
| CN103479991A (en) * | 2013-10-14 | 2014-01-01 | 张桂赫 | Traditional Chinese medicine pill for treating dysphoria and sleeplessness and preparation method of pill |
| CN104547365A (en) * | 2014-12-24 | 2015-04-29 | 武海波 | Nerve-soothing traditional Chinese medicinal composition |
| CN105148232A (en) * | 2015-09-24 | 2015-12-16 | 张秀婵 | Traditional Chinese medicine composition used for treating amnesia |
| CN105148232B (en) * | 2015-09-24 | 2019-05-10 | 袁增强 | A kind of Chinese medicine composition for treating amnesia |
| CN107362272A (en) * | 2017-08-31 | 2017-11-21 | 江西金顶药业有限公司 | A kind of Yangxue Anshen Syrup |
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