CN101549078A - Pharmaceutical composition for treating intractable insomnia and preparation method thereof - Google Patents
Pharmaceutical composition for treating intractable insomnia and preparation method thereof Download PDFInfo
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- CN101549078A CN101549078A CNA2008101034067A CN200810103406A CN101549078A CN 101549078 A CN101549078 A CN 101549078A CN A2008101034067 A CNA2008101034067 A CN A2008101034067A CN 200810103406 A CN200810103406 A CN 200810103406A CN 101549078 A CN101549078 A CN 101549078A
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Abstract
The invention discloses a pharmaceutical composition for treating intractable insomnia and a preparation method thereof, and the active ingredients of the composition are prepared by extracting more than ten medicinal materials of barbary wolfberry fruit, radix rehmanniae preparata, radix salviae miltiorrhizae, common macrocarpium fruit, fossilizid, common yam rhizome, oriental waterplantain rhizome, tree peony bark, Indian buead, peach seed, safflower, Chinese thorowax root, date seed, platycladi seed and the like. The unique medicinal active ingredients in the pharmaceutical composition have the efficacies of invigorating kidney, nourishing essence, nourishing liver and improving eyesight, thereby having better efficacies for treating the refractory insomnia.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen that is used for the treatment of intractable insomnia and preparation method thereof.
Technical background
Insomnia is called again on the traditional Chinese medical science is insomnia, and is called neurasthenia on the doctor trained in Western medicine, and very common in the sleep disorder is exactly insomnia.
The main performance of insomnia is exactly a difficulty falling asleep, easily wake up and early awakening in the middle of the sleep, sleep quality is low, obviously reduce the length of one's sleep, and serious patient also lies awake all night, and long-term insomnia causes upsets, fatigue and weak, even headache, dreaminess, spontaneous perspiration, hypomnesis, also can cause a series of clinical symptoms, and bring out some psychosomatic diseasies.In loneliness noiseless late into the night, have only you people to toss about in bed, be difficult to fall asleep, and it is just anxious more and uneasy to can't fall asleep more, is again that you more have difficulty in going to sleep conversely, and various ways are used up and still do not gathered effect, have to one hour one hour in the past, still do not sleep, work study in the 2nd day does not have energy, dizziness, dim eyesight, dispirited, sleepy weak, at the thought of so going down to influence the health of oneself, family, work and future, a kind of hardship of feeling embarrassed to mention has caused anxiety, depression, Mental Subnormality.
It is reported, China has 300,000,000 adults tormented by sleep disorder in various degree at present, owing to lack cognitive, only one one-tenth insomniac seeks medical advice, most patients fail to take correct Therapeutic Method, even blindly medication, the addiction problem to medicine occurred, the formation vicious cycle that goes round and begins again has not only stopped over the state of an illness, has also increased the weight of insomnia.The expert reminds, and does not have enough sleep or poor sleeping quality can recognize that to do be the insomnia.
Insomnia is not the performance that Mental Health suffers damage, also is to bring out depressed important risk factor.For another example, headache can hinder sleep, and insomnia also can cause headache.In addition, the people that those, table was upset lengths of one's sleep, the easier problem that the cardiovascular aspect occurs.The orthobiosis that insomnia simultaneously can damage people in many aspects, as: the people of insomnia normal occur absent minded, work quality is poor, memory, logical reasoning and aprosexia, tired, irritability or forgetful etc., influence work and study, and then cause the anxiety of pressure and inter personal contact.
Chinese medicine thinks that the reason of insomnia is a lot, ponders over overstrain, interior sad spleen, and negative and positive are not handed over, disarmony between the heart and kidney, hyperactivity of fire caused by deficiency of YIN, factors such as insufficiency of heart-QI and disorder of the stomach influence the mind and have a sleepless night.The generation of insomnia is always relevant with heart spleen Liver and kidney and deficiency of YIN-blood, and men outnumbered women for the total genus of its pathological change, and negative and positive are not handed over.Treatment is worked as with reinforce insufficiency and reduce excessiveness, and coordinating YIN and YANG is a principle, its deficiency of nourishing for deficiency, benefiting QI and nourishing blood, nourishing the liver and kidney; Reality person's reducing for the excess syndrome, promoting digestion and regulating the middle JIAO.
The theory that " being insomnia " all arranged according to the traditional Chinese medical science " brain master gods; liver master feelings will; heart governing blood and vessels " and the five internal organs, should start with from the kidney invigorating nourishing the liver theory, adopt Chinese medicine Fructus Lycii, Radix Rehmanniae Preparata, Fructus Corni etc. for the raw material prescription forms, have the effect of good nourishing the liver and kidney, can be widely used in the old and feeble insufficiency of function that is caused, be particularly useful for the liver deficiency that occurs in all chronic disease processes, the disease of damage of kidney-YIN, can receive curative effect preferably for the treatment intractable insomnia.
Summary of the invention:
One of purpose of the present invention provides a kind of drug regimen that is used for the treatment of intractable insomnia.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Fructus Lycii 150-450 part Radix Rehmanniae Preparata 100-300 part Radix Salviae Miltiorrhizae 150-450 part
Fructus Corni 100-300 part Os Draconis 50-150 part Rhizoma Dioscoreae 100-300 part
Rhizoma Alismatis 100-300 part Cortex Moutan 100-300 part Poria 100-300 part
Semen Persicae 50-150 part Flos Carthami 50-150 part Radix Bupleuri 50-150 part
Semen Ziziphi Spinosae 100-300 part Semen Platycladi 50-150 part
The active component that preferred following raw materials according is made, curative effect is better:
300 parts of 150 parts of Radix Salviae Miltiorrhizaes of 300 parts of Radix Rehmanniae Preparata of Fructus Lycii
150 parts of 100 portions of Rhizoma Dioscoreaes of 150 parts of Os Draconis of Fructus Corni
150 parts in 150 parts of Poria of 150 parts of Cortex Moutans of Rhizoma Alismatis
100 parts of 100 parts of Radix Bupleuri of 100 parts of Flos Carthamis of Semen Persicae
100 parts of 150 parts of Semen Platycladi of Semen Ziziphi Spinosae
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Salviae Miltiorrhizae adds 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) Fructus Lycii, Radix Rehmanniae Preparata, Fructus Corni, Os Draconis, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria, Semen Persicae, Flos Carthami, Radix Bupleuri, Semen Ziziphi Spinosae, Semen Platycladi decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds acceptable accessories and makes different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has the kidney invigorating and essence nourishing, and the effect of nourishing the liver to improve visual acuity can be received curative effect preferably for the treatment intractable insomnia.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
300 parts of 150 parts of Radix Salviae Miltiorrhizaes of 300 parts of Radix Rehmanniae Preparata of Fructus Lycii
150 parts of 100 portions of Rhizoma Dioscoreaes of 150 parts of Os Draconis of Fructus Corni
150 parts in 150 parts of Poria of 150 parts of Cortex Moutans of Rhizoma Alismatis
100 parts of 100 parts of Radix Bupleuri of 100 parts of Flos Carthamis of Semen Persicae
100 parts of 150 parts of Semen Platycladi of Semen Ziziphi Spinosae
2. preparation technology
(1) Radix Salviae Miltiorrhizae adds 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) Fructus Lycii, Radix Rehmanniae Preparata, Fructus Corni, Os Draconis, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria, Semen Persicae, Flos Carthami, Radix Bupleuri, Semen Ziziphi Spinosae, Semen Platycladi decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds cane sugar powder, and mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
300 parts of 150 parts of Radix Salviae Miltiorrhizaes of 300 parts of Radix Rehmanniae Preparata of Fructus Lycii
150 parts of 100 portions of Rhizoma Dioscoreaes of 150 parts of Os Draconis of Fructus Corni
150 parts in 150 parts of Poria of 150 parts of Cortex Moutans of Rhizoma Alismatis
100 parts of 100 parts of Radix Bupleuri of 100 parts of Flos Carthamis of Semen Persicae
100 parts of 150 parts of Semen Platycladi of Semen Ziziphi Spinosae
2. preparation technology
(1) Radix Salviae Miltiorrhizae adds 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) Fructus Lycii, Radix Rehmanniae Preparata, Fructus Corni, Os Draconis, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria, Semen Persicae, Flos Carthami, Radix Bupleuri, Semen Ziziphi Spinosae, Semen Platycladi decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
300 parts of 150 parts of Radix Salviae Miltiorrhizaes of 300 parts of Radix Rehmanniae Preparata of Fructus Lycii
150 parts of 100 portions of Rhizoma Dioscoreaes of 150 parts of Os Draconis of Fructus Corni
150 parts in 150 parts of Poria of 150 parts of Cortex Moutans of Rhizoma Alismatis
100 parts of 100 parts of Radix Bupleuri of 100 parts of Flos Carthamis of Semen Persicae
100 parts of 150 parts of Semen Platycladi of Semen Ziziphi Spinosae
2. preparation technology
(1) Radix Salviae Miltiorrhizae adds 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) Fructus Lycii, Radix Rehmanniae Preparata, Fructus Corni, Os Draconis, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria, Semen Persicae, Flos Carthami, Radix Bupleuri, Semen Ziziphi Spinosae, Semen Platycladi decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, sieves, and adds starch, and mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of drug regimen that is used for the treatment of intractable insomnia is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Fructus Lycii 150-450 part Radix Rehmanniae Preparata 100-300 part Radix Salviae Miltiorrhizae 150-450 part
Fructus Corni 100-300 part Os Draconis 50-150 part Rhizoma Dioscoreae 100-300 part
Rhizoma Alismatis 100-300 part Cortex Moutan 100-300 part Poria 100-300 part
Semen Persicae 50-150 part Flos Carthami 50-150 part Radix Bupleuri 50-150 part
Semen Ziziphi Spinosae 100-300 part Semen Platycladi 50-150 part.
2, a kind of drug regimen that is used for the treatment of intractable insomnia according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
300 parts of 150 parts of Radix Salviae Miltiorrhizaes of 300 parts of Radix Rehmanniae Preparata of Fructus Lycii
150 parts of 100 portions of Rhizoma Dioscoreaes of 150 parts of Os Draconis of Fructus Corni
150 parts in 150 parts of Poria of 150 parts of Cortex Moutans of Rhizoma Alismatis
100 parts of 100 parts of Radix Bupleuri of 100 parts of Flos Carthamis of Semen Persicae
100 parts of 150 parts of Semen Platycladi of Semen Ziziphi Spinosae.
3, according to the described a kind of drug regimen that is used for the treatment of intractable insomnia of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Salviae Miltiorrhizae adds 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) Fructus Lycii, Radix Rehmanniae Preparata, Fructus Corni, Os Draconis, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria, Semen Persicae, Flos Carthami, Radix Bupleuri, Semen Ziziphi Spinosae, Semen Platycladi decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds acceptable accessories and makes different preparations such as granule, sheet, capsule.
4, according to any one described a kind of drug regimen that is used for the treatment of intractable insomnia among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen that is used for the treatment of intractable insomnia of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101034067A CN101549078A (en) | 2008-04-03 | 2008-04-03 | Pharmaceutical composition for treating intractable insomnia and preparation method thereof |
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| CNA2008101034067A CN101549078A (en) | 2008-04-03 | 2008-04-03 | Pharmaceutical composition for treating intractable insomnia and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991774A (en) * | 2010-11-23 | 2011-03-30 | 张秀兰 | Medicine for treating insomnia and preparation method thereof |
| CN103127472A (en) * | 2013-03-23 | 2013-06-05 | 郭玮 | Traditional Chinese medicine compound for refractory insomnia |
| CN103710195A (en) * | 2014-01-13 | 2014-04-09 | 唐赢 | Wine for improving sleeping depth |
| WO2014126486A1 (en) * | 2013-02-15 | 2014-08-21 | Leano Milagros B | Pharmacological indications and uses of preparations from dioscorea hispida |
| CN104825932A (en) * | 2015-05-20 | 2015-08-12 | 南京华宽信息咨询中心 | Traditional Chinese medicine for treating insomnia |
-
2008
- 2008-04-03 CN CNA2008101034067A patent/CN101549078A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991774A (en) * | 2010-11-23 | 2011-03-30 | 张秀兰 | Medicine for treating insomnia and preparation method thereof |
| WO2014126486A1 (en) * | 2013-02-15 | 2014-08-21 | Leano Milagros B | Pharmacological indications and uses of preparations from dioscorea hispida |
| CN103127472A (en) * | 2013-03-23 | 2013-06-05 | 郭玮 | Traditional Chinese medicine compound for refractory insomnia |
| CN103710195A (en) * | 2014-01-13 | 2014-04-09 | 唐赢 | Wine for improving sleeping depth |
| CN104825932A (en) * | 2015-05-20 | 2015-08-12 | 南京华宽信息咨询中心 | Traditional Chinese medicine for treating insomnia |
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Open date: 20091007 |