CN101502482B - Toothpaste containing coenzyme Q10 and preparation method thereof - Google Patents
Toothpaste containing coenzyme Q10 and preparation method thereof Download PDFInfo
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- CN101502482B CN101502482B CN2009100942609A CN200910094260A CN101502482B CN 101502482 B CN101502482 B CN 101502482B CN 2009100942609 A CN2009100942609 A CN 2009100942609A CN 200910094260 A CN200910094260 A CN 200910094260A CN 101502482 B CN101502482 B CN 101502482B
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- 229940034610 toothpaste Drugs 0.000 title claims abstract description 61
- 239000000606 toothpaste Substances 0.000 title claims abstract description 61
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims abstract description 41
- 235000017471 coenzyme Q10 Nutrition 0.000 title claims abstract description 36
- 229940110767 coenzyme Q10 Drugs 0.000 title claims abstract description 36
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title abstract description 4
- 239000000284 extract Substances 0.000 claims abstract description 43
- 241000411851 herbal medicine Species 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000008367 deionised water Substances 0.000 claims abstract description 14
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 14
- 239000004088 foaming agent Substances 0.000 claims abstract description 12
- 239000000080 wetting agent Substances 0.000 claims abstract description 12
- 230000002708 enhancing effect Effects 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 claims description 12
- 239000011230 binding agent Substances 0.000 claims description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 230000023597 hemostasis Effects 0.000 claims description 10
- 241000180649 Panax notoginseng Species 0.000 claims description 9
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 9
- 230000036592 analgesia Effects 0.000 claims description 9
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 9
- 229930182494 ginsenoside Natural products 0.000 claims description 9
- 229940089161 ginsenoside Drugs 0.000 claims description 9
- RLQYRXCUPVKSAW-UHFFFAOYSA-M 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride Chemical compound [Cl-].COC1=C(OC)C=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=C1 RLQYRXCUPVKSAW-UHFFFAOYSA-M 0.000 claims description 8
- 241001533947 Psammosilene Species 0.000 claims description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims description 8
- RIDQRIPSFYHEGL-UHFFFAOYSA-N fibrauretin Natural products CC12CC=C3C(=O)OC(CC3(C)C1C(=O)C=CC2=O)c4cocc4 RIDQRIPSFYHEGL-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
- 244000246386 Mentha pulegium Species 0.000 claims description 7
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 7
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 7
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
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- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 7
- 229930182478 glucoside Natural products 0.000 claims description 7
- 150000008131 glucosides Chemical class 0.000 claims description 7
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- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 6
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- 239000009609 fructus phyllanthi Substances 0.000 claims description 6
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 6
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 6
- 229930182490 saponin Natural products 0.000 claims description 6
- 150000007949 saponins Chemical class 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- RBNWAMSGVWEHFP-UHFFFAOYSA-N trans-p-Menthane-1,8-diol Chemical compound CC(C)(O)C1CCC(C)(O)CC1 RBNWAMSGVWEHFP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000811 xylitol Substances 0.000 claims description 6
- 235000010447 xylitol Nutrition 0.000 claims description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
- 235000005979 Citrus limon Nutrition 0.000 claims description 5
- 244000131522 Citrus pyriformis Species 0.000 claims description 5
- 241001264174 Cordyceps militaris Species 0.000 claims description 5
- 241000233866 Fungi Species 0.000 claims description 5
- 240000001307 Myosotis scorpioides Species 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 5
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 5
- 229940109275 cyclamate Drugs 0.000 claims description 5
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 5
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 5
- 238000000855 fermentation Methods 0.000 claims description 5
- 230000004151 fermentation Effects 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 235000011803 sesame oil Nutrition 0.000 claims description 5
- 239000008159 sesame oil Substances 0.000 claims description 5
- 239000000377 silicon dioxide Substances 0.000 claims description 5
- 235000012239 silicon dioxide Nutrition 0.000 claims description 5
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 244000299461 Theobroma cacao Species 0.000 claims description 4
- 235000009470 Theobroma cacao Nutrition 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 4
- 125000004185 ester group Chemical group 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 235000015424 sodium Nutrition 0.000 claims description 4
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- 244000261559 Smilax china Species 0.000 claims description 3
- 235000000485 Smilax china Nutrition 0.000 claims description 3
- 240000009022 Smilax rotundifolia Species 0.000 claims description 3
- 235000003205 Smilax rotundifolia Nutrition 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 235000020710 ginseng extract Nutrition 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 229930006948 p-menthane-3,8-diol Natural products 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 235000010356 sorbitol Nutrition 0.000 claims description 3
- RBNWAMSGVWEHFP-WAAGHKOSSA-N terpin Chemical compound CC(C)(O)[C@H]1CC[C@@](C)(O)CC1 RBNWAMSGVWEHFP-WAAGHKOSSA-N 0.000 claims description 3
- 229950010257 terpin Drugs 0.000 claims description 3
- 241000208340 Araliaceae Species 0.000 claims description 2
- 241000207199 Citrus Species 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 108010016626 Dipeptides Proteins 0.000 claims description 2
- 244000166124 Eucalyptus globulus Species 0.000 claims description 2
- 235000004692 Eucalyptus globulus Nutrition 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 235000019502 Orange oil Nutrition 0.000 claims description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 2
- 244000061456 Solanum tuberosum Species 0.000 claims description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 229940105329 carboxymethylcellulose Drugs 0.000 claims description 2
- 239000000679 carrageenan Substances 0.000 claims description 2
- 235000010418 carrageenan Nutrition 0.000 claims description 2
- 229920001525 carrageenan Polymers 0.000 claims description 2
- 229940113118 carrageenan Drugs 0.000 claims description 2
- 235000020971 citrus fruits Nutrition 0.000 claims description 2
- 239000000084 colloidal system Substances 0.000 claims description 2
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 2
- 238000002481 ethanol extraction Methods 0.000 claims description 2
- 235000008434 ginseng Nutrition 0.000 claims description 2
- -1 glucide Chemical compound 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 239000012633 leachable Substances 0.000 claims description 2
- 235000013923 monosodium glutamate Nutrition 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 235000019198 oils Nutrition 0.000 claims description 2
- 239000010502 orange oil Substances 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 2
- 229940083542 sodium Drugs 0.000 claims description 2
- 229940073490 sodium glutamate Drugs 0.000 claims description 2
- 229920005992 thermoplastic resin Polymers 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000000341 volatile oil Substances 0.000 claims description 2
- 239000002023 wood Substances 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 2
- 241001248610 Ophiocordyceps sinensis Species 0.000 claims 1
- 230000036541 health Effects 0.000 abstract description 11
- 208000007565 gingivitis Diseases 0.000 abstract description 6
- 206010018275 Gingival atrophy Diseases 0.000 abstract description 5
- 210000004027 cell Anatomy 0.000 abstract description 5
- 201000001245 periodontitis Diseases 0.000 abstract description 5
- 208000007117 Oral Ulcer Diseases 0.000 abstract description 2
- 208000002399 aphthous stomatitis Diseases 0.000 abstract description 2
- 210000000170 cell membrane Anatomy 0.000 abstract description 2
- 230000035876 healing Effects 0.000 abstract description 2
- 238000005728 strengthening Methods 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 238000005282 brightening Methods 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
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- 241000245665 Taraxacum Species 0.000 description 4
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- 238000013019 agitation Methods 0.000 description 3
- 238000009924 canning Methods 0.000 description 3
- 210000004195 gingiva Anatomy 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 206010018276 Gingival bleeding Diseases 0.000 description 2
- 208000024283 Gingival haemorrhages Diseases 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 208000012239 Developmental disease Diseases 0.000 description 1
- 206010018286 Gingival pain Diseases 0.000 description 1
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- 206010061218 Inflammation Diseases 0.000 description 1
- 208000010641 Tooth disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
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- 238000004140 cleaning Methods 0.000 description 1
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- 210000000214 mouth Anatomy 0.000 description 1
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- 235000013772 propylene glycol Nutrition 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to a toothpaste containing coenzyme Q10 and a preparation method thereof, in particular to a toothpaste composition. Belongs to the field of oral health care products. The toothpaste contains 1-2 wt% of coenzyme Q10, 0.5-2 wt% of Chinese herbal medicine extract and the balance of supplementary material. The dosage of the formula is preferably that the proportion of the coenzyme Q10 mixture in the toothpaste is 2%, the proportion of the Chinese herbal medicine extract is 0.7%, the abrasive is 35%, the adhesive is 1.5%, the wetting agent is 35%, the flavoring agent is 0.2%, the foaming agent is 2.5%, the essence is 1.5%, and the deionized water is 21.6%. The toothpaste containing coenzyme Q10 has the health care functions of brightening and whitening teeth, stopping bleeding of gum and healing oral ulcer, and also has the functions of enabling coenzyme Q10 and Chinese herbal medicine extracts to penetrate through gum cell membranes to enable gum cells to obtain energy, enhancing tissue vitality, essentially protecting gum, preventing and treating periodontitis, gingivitis and gum atrophy, thereby achieving the purposes of strengthening gum and strengthening teeth.
Description
Technical field
The present invention relates to the compositions of a kind of toothpaste that contains coenzyme Q10 and preparation method thereof, particularly toothpaste.Belong to the oral health care product field.
Background technology
Coenzyme Q10 is that human body newly becomes the indispensable material of metabolism, is present in the human body cell " mitochondrion ", participates in energy ATP and synthesizes; Have antioxidation and cell membrane repair; Along with the growth at human body age, human body coenzyme Q10 synthesis capability descends after 20 years old, and concentration is lower than when a certain amount of; Can cause Developmental and Metabolic Disorder, bring out tooth diseases such as periodontitis, gingivitis, gingival atrophy.
Toothpaste is one of people's articles for daily use, can cleaning oral cavity tooth and antiplaque effect with it.Toothpaste in the market is of a great variety, differs from one another, and is liked and acceptance by consumers in general with its abnormal smells from the patient and effect uniqueness.Along with people's improves the understanding of health care gradually; Existing toothpaste can not satisfy the different demands of consumer far away; The most of people that particularly cause gingival hemorrhage to oral inflammation; Resistance of human body is descended, be prone to grow other diseases, functional medical toothpaste has irreplaceable effect to improving human health.
People more and more paid attention to the health and medical function of toothpaste to various products in recent years, and people grow with each passing day to interest, the demand of toothpaste with health care usefulness.
Summary of the invention
The objective of the invention is to invent a kind of health-care toothpaste that contains coenzyme Q10, particularly a kind of health-care toothpaste that contains reduced coenzyme Q 10, it has effects such as hemostasis, analgesia, detumescence, antibacterial, antiinflammatory, antioxygen, resisting fatigue, enhancing immunity; Its drug effect is wide, effective without any side effects; This health-care toothpaste can effectively be prevented and treated gingivitis, gingival hemorrhage, periodontitis; Gingival swelling and pain, health care usefulness toothpaste.
The present invention also aims to adopt coenzyme Q10; Particularly reduced coenzyme Q 10 and Chinese herbal medicine extract see through the gingival cell film; Make gingival cell obtain energy, organizational vitality strengthens, from maintenance gingiva in essence; Control periodontitis, gingivitis, gingival atrophy reach the health care purpose of being good for the gum teeth consolidating.
Zhou Yan, gingivitis, gingival atrophy reach the health care purpose of being good for the gum teeth consolidating.
The present invention contains the toothpaste of coenzyme Q10 and the purpose of method for preparing is to accomplish like this: it is characterized in that by weight percentage coenzyme Q10 is 1%-2% in the toothpaste, Chinese herbal medicine extract is 0.5%-2%, and all the other adjuvants are the conventional material of preparing toothpaste.
The prescription consumption preferably; By described percentage by weight; Coenzyme Q10 mixture shared ratio in toothpaste is 2%; The shared ratio of Chinese herbal medicine extract is 0.7%, and abrasive 35%, binding agent 1.5%, wetting agent 35%, correctives 0.2%, foaming agent 2.5%, essence 1.5%, deionized water are 21.6%..
Contained coenzyme Q10 is a reduced coenzyme Q 10, and wherein percent of reduced coenzyme Q 10 and oxidized coenzyme Q10 is 95-100%: 0-5%, and oxidized coenzyme Q10 is 2005 editions standards of Chinese Pharmacopoeia, and reduced coenzyme Q 10 is applicant's company standard; Structural formula is:
(reduced coenzyme Q 10 structural formula) (oxidized coenzyme Q10 structural formula)
In the said Chinese herbal medicine extract, hemostasis, analgesia, a detumescence type Chinese herbal medicine extract are 40%, and antibacterial, anti-inflammatory type Chinese herbal medicine extract is 30%, and antioxygen, resisting fatigue, enhancing immunity class Chinese herbal medicine extract are 30%.
Said interpolation has hemostasis, analgesia, repercussive Chinese herbal medicine extract: Folium Ginseng extracts ginsenoside (ginsenoside Rg+ginseng saponin Re >=2.25%), Radix Psammosilenes (45% alcohol extract >=40%), Rhizoma Paridis (opaque and colloid); Pull out chinaroot greenbrier (60% ethanol leachable >=15%; The preparatory saponin of potato >=0.04%), Radix Notoginseng total glucosides (ginsenoside Rg+ginsenoside Rb+ Panax Notoginseng saponin R, sum total >=5%); Preferred Radix Psammosilenes, Rhizoma Paridis, Radix Notoginseng total glucosides, more preferably Radix Psammosilenes, Radix Notoginseng total glucosides in the prescription.
Said interpolation has, and Chinese herbal medicine extract antibacterial, antiinflammatory is: Taraxacum (water containing ethanol extraction extractum); Terpinol (terpin tetraol >=3%); Herba Houttuyniae (cold-water-soluble extractum >=10%) fibrauretin (fibrauretin >=90%), preferred Taraxacum, fibrauretin, more preferably Taraxacum in the prescription.
Said interpolation has antioxygen, resisting fatigue; The Chinese herbal medicine extract of enhancing immunity is: Radix Rhodiolae (rhodioside content >=0.5%); Cordyceps militaris (L.) Link. (opaque), artificial fermentation Chinese caterpillar fungus extract (opaque), Semen Vignae Cylindricae bandit (volatile oil >=5%ml/g, Folium eucalypti globueli (Eucalyptus globulus Labill.) essence >=3%), Fructus Phyllanthi (cold-water-soluble extractum >=30%); Preferred Radix Rhodiolae, Cordyceps militaris (L.) Link., Fructus Phyllanthi, more preferably artificial fermentation Chinese caterpillar fungus extract in the prescription.
The conventional adjuvant of said toothpaste is: abrasivus 15%-35%, wetting agent 15%-35%, binding agent 0.6%-2.7%; Foaming agent 0.6%-2.7%; Correctives 0.05%-0.25%; Essence 1%-2%; Deionized water 20%-25%.
Reduced coenzyme Q 10 is mixed with Chinese herbal medicine extract; Add wetting agent and deionized water and stirring, process the deionized water suspension; Mix with abrasivus, binding agent, foaming agent, correctives again, stir, grind and vacuum outgas; Add essence at last and stir, grind and vacuum outgas, obtain lotion of toothpaste.
The abrasivus that toothpaste adds is: calcium carbonate, calcium hydrogen phosphate, silicon dioxide, aluminium hydroxide, Alumina hydrate, thermoplastic resin, preferred silicon dioxide, aluminium hydroxide, more preferably calcium hydrogen phosphate in the prescription;
The wetting agent that toothpaste adds is: sorbitol, glycerol, propylene glycol, xylitol, Polyethylene Glycol (400-600), preferably glycerine, xylitol, Polyethylene Glycol, more preferably xylitol in the prescription;
The binding agent that toothpaste adds is: extra large bath acid sodium, carboxymethyl cellulose, xanthan gum, hydroxyethyl-cellulose, guar gum, carrageenan, preferred extra large bath acid sodium, carboxymethyl cellulose, hydroxyethyl-cellulose, more preferably carboxymethyl cellulose in the prescription;
The correctives that toothpaste adds is: sucrose, glucide, cyclamate, dipeptide sodium, preferably sucrose, glucide, more preferably cyclamate in the prescription;
The essence that toothpaste adds is: peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, citrus seed oil, winter wood oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Borneolum Syntheticum; Preferred peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, Borneolum Syntheticum, more preferably Oleum Menthae Rotundifoliae, peppermint in the prescription;
The foaming agent that toothpaste adds is: sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, phenolic group sodium glutamate; Preferred N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, more preferably sodium lauryl sulphate in the prescription;
The present invention contains the toothpaste of coenzyme Q10, and general toothpaste brilliant white cleans the teeth except that having, the gingiva hemostasis, oral ulcer healing health care; Also have coenzyme Q10 and Chinese herbal medicine extract and see through the gingival cell film; Make gingival cell obtain energy, organizational vitality strengthens, from maintenance gingiva in essence; Control periodontitis, gingivitis, gingival atrophy, thus reach the purpose of being good for the gum teeth consolidating.
The specific embodiment:
The coenzyme Q10 that has gross weight 1%-2% in the toothpaste of the present invention; The Chinese herbal medicine extract that also adds the effect such as hemostasis, antiinflammatory, analgesia of 0.5%-1%; Other component also has abrasivus 30%-35%; Wetting agent 30%-35%; Binding agent 0.6%-2.7%; Foaming agent 0.6%-2.7%; Correctives 0.05%-0.25%; Essence 1%-2%; Deionized water is 20%-25%.
(reduced coenzyme Q 10 structural formula) (oxidized coenzyme Q10 structural formula)
Method for preparing is: with reduced form or oxidized coenzyme Q10 and Chinese herbal medicine extract with effects such as hemostasis, antiinflammatory, analgesia, antibacterial, antioxidation, resisting fatigue; Adding wetting agent or deionized water and stirring are processed the deionized water suspension and are mixed with abrasivus, binding agent, foaming agent, correctives, stir, grind and vacuum outgas; Add essence at last and stir, grind and vacuum outgas, obtain lotion of toothpaste.
Embodiment 1: take by weighing reduced coenzyme Q 10 200g, Chinese herbal medicine extract arasaponin 28g, Taraxacum extractum 21g, Fructus Phyllanthi extractum 21g; Add glycerol 3500g, add deionized water 2160ml again and stir into suspension, add calcium hydrogen phosphate 3500g, carboxymethyl cellulose 150g, sodium lauryl sulphate 250g; Cyclamate 20g stirring, grinding, vacuum outgas; Add Oleum Menthae Rotundifoliae 150g agitation grinding, vacuum outgas at last, get the coenzyme Q10 lotion of toothpaste, through aseptic canning; Pack 100, every 100g.
Embodiment 2: take by weighing reduced coenzyme Q 10 240g; Chinese herbal medicine extract Radix Psammosilenes 33.6g, terpin tetraol 25.2g, artificial fermentation Chinese caterpillar fungus extract 25.2g, adding Polyethylene Glycol (400) 4200g add deionized water 2592ml again and stir into suspension, add calcium carbonate 4200g, hydroxyethyl-cellulose 180g, sodium lauryl sulphate 300g; Glucide 24g stirring, grinding, vacuum outgas; Add peppermint 180g agitation grinding, vacuum outgas at last, get the coenzyme Q10 lotion of toothpaste, through aseptic canning; Pack 100, every 120g.
Embodiment 3: take by weighing reduced coenzyme Q 10 120g, Chinese herbal medicine extract Rhizoma Paridis 16.8g, fibrauretin 12.6g, Radix Rhodiolae 12.6g; Add sorbitol (400) 2100g, add deionized water 1296ml again and stir into suspension, add silicon dioxide 2100g, hydroxyethyl-cellulose 90g, sodium lauryl sulphate 150g; Glucide 12g stirring, grinding, vacuum outgas; Add lemon sesame oil 90g agitation grinding, vacuum outgas at last, get the coenzyme Q10 lotion of toothpaste, through aseptic canning; Pack 100, every 60g.
Claims (12)
1. a toothpaste that contains coenzyme Q10 is characterized in that by weight percentage, and coenzyme Q10 is 1%-2% in the toothpaste, and Chinese herbal medicine extract is 0.5%-2%, and all the other adjuvants are the conventional material of preparing toothpaste;
In the said Chinese herbal medicine extract, hemostasis, analgesia, a detumescence type Chinese herbal medicine extract are 40%, and antibacterial, anti-inflammatory type Chinese herbal medicine extract is 30%, and antioxygen, resisting fatigue, enhancing immunity class Chinese herbal medicine extract are 30%;
Said interpolation has hemostasis, analgesia, repercussive Chinese herbal medicine extract: Folium Ginseng extracts ginsenoside, Radix Psammosilenes, Rhizoma Paridis, pulls out chinaroot greenbrier, Radix Notoginseng total glucosides; Wherein said Folium Ginseng extracts the ginsenoside and is ginsenoside Rg+ ginseng saponin Re >=2.25%; Said Radix Psammosilenes is 45% alcohol extract >=40%; Said Rhizoma Paridis is opaque and colloid, and the said chinaroot greenbrier that pulls out is 60% ethanol leachable >=15%, the preparatory saponin of potato >=0.04%; Said Radix Notoginseng total glucosides is a ginsenoside Rg+ ginsenoside Rb+ Panax Notoginseng saponin R, sum total >=5%;
Said interpolation has, and Chinese herbal medicine extract antibacterial, antiinflammatory is: Herba Taraxaci, terpinol, Herba Houttuyniae, fibrauretin; Wherein said Herba Taraxaci is a water containing ethanol extraction extractum; Said terpinol is terpin tetraol >=3%; Said Herba Houttuyniae is cold-water-soluble extractum >=10%; Said fibrauretin is fibrauretin >=90%;
Said interpolation has antioxygen, resisting fatigue, and the Chinese herbal medicine extract of enhancing immunity is: Radix Rhodiolae, Cordyceps militaris (L.) Link., artificial fermentation Chinese caterpillar fungus extract, Semen Vignae Cylindricae bandit, Fructus Phyllanthi; Wherein said Radix Rhodiolae is rhodioside content >=0.5%; Said Cordyceps militaris (L.) Link. is an opaque; Said artificial fermentation Chinese caterpillar fungus extract is an opaque; Said Semen Vignae Cylindricae bandit is volatile oil >=5%ml/g, Folium eucalypti globueli (Eucalyptus globulus Labill.) essence >=3%; Said Fructus Phyllanthi is cold-water-soluble extractum >=30%.
2. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that the conventional adjuvant of said toothpaste is: abrasivus 15%-35%, wetting agent 15%-35%, binding agent 0.6%-2.7%; Foaming agent 0.6%-2.7%; Correctives 0.05%-0.25%; Essence 1%-2%; Deionized water 20%-25%, the conventional adjuvant component of coenzyme Q10, Chinese herbal medicine extract and each toothpaste sum is 100%.
3. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that it is Radix Psammosilenes, Rhizoma Paridis, Radix Notoginseng total glucosides that said interpolation has hemostasis, analgesia, repercussive Chinese herbal medicine extract.
4. the toothpaste that contains coenzyme Q10 according to claim 3 is characterized in that it is Radix Psammosilenes, Radix Notoginseng total glucosides that said interpolation has hemostasis, analgesia, repercussive Chinese herbal medicine extract.
5. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that it is Herba Taraxaci, fibrauretin that said interpolation has Chinese herbal medicine extract antibacterial, antiinflammatory.
6. the toothpaste that contains coenzyme Q10 according to claim 5 is characterized in that it is Herba Taraxaci that said interpolation has Chinese herbal medicine extract antibacterial, antiinflammatory.
7. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that said interpolation has antioxygen, resisting fatigue, and the Chinese herbal medicine extract of enhancing immunity is Radix Rhodiolae, Cordyceps militaris (L.) Link., Fructus Phyllanthi.
8. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that said interpolation has antioxygen, resisting fatigue, and the Chinese herbal medicine extract of enhancing immunity is that artificial ferment cordyceps sinensis is smart.
9. the method for preparing that contains coenzyme Q10 toothpaste according to claim 1 and 2; It is characterized in that: reduced coenzyme Q 10 is mixed with Chinese herbal medicine extract; Add wetting agent and deionized water and stirring, process the deionized water suspension; Mix with abrasivus, binding agent, foaming agent, correctives again, stir, grind and vacuum outgas, add essence at last and stir, grind and vacuum outgas, obtain lotion of toothpaste.
10. the method for preparing that contains coenzyme Q10 toothpaste according to claim 9 is characterized in that the abrasivus that toothpaste adds is: calcium carbonate, calcium hydrogen phosphate, silicon dioxide, aluminium hydroxide, Alumina hydrate, thermoplastic resin;
The wetting agent that toothpaste adds is: sorbitol, glycerol, propylene glycol, xylitol, molecular weight are the Polyethylene Glycol of 400-600;
The binding agent that toothpaste adds is: extra large bath acid sodium, carboxymethyl cellulose, xanthan gum, hydroxyethyl-cellulose, guar gum, carrageenan;
The correctives that toothpaste adds is: sucrose, glucide, cyclamate, dipeptide sodium;
The essence that toothpaste adds is: peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, citrus seed oil, winter wood oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Borneolum Syntheticum;
The foaming agent that toothpaste adds is: sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, phenolic group sodium glutamate.
11. the method for preparing that contains coenzyme Q10 toothpaste according to claim 10 is characterized in that abrasivus is silicon dioxide, aluminium hydroxide; Wetting agent is glycerol, xylitol, Polyethylene Glycol; Binding agent is extra large bath acid sodium, carboxymethyl cellulose, hydroxyethyl-cellulose; Correctives is sucrose, glucide; Essence is peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, Borneolum Syntheticum; Foaming agent is N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate.
12. the method for preparing that contains coenzyme Q10 toothpaste according to claim 10 is characterized in that abrasivus is a calcium hydrogen phosphate; Wetting agent is an xylitol; Binding agent is a carboxymethyl cellulose; Correctives is a cyclamate; Essence is Oleum Menthae Rotundifoliae, peppermint; Foaming agent is a sodium lauryl sulphate.
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