CN101474270B - Cough-relieving tablet - Google Patents

Abstract

The invention discloses cough-relieving tablets which comprise dry extract powder extracted from medicinal materials, sucrose powder, medicinal talcum powder, medicinal silicon dioxide, medicinal magnesium stearate and 20-95% medicinal alcohol. The preparation method comprises the steps of uniformly mixing sucrose powder with 20-95% of medicinal alcohol, uniformly mixing the sucrose powder with medicinal material extracted dry extract powder, preparing into small granules which take wet sucrose granules as crystal nuclei and externally wrap the medicinal material extracted dry extract powder, uniformly mixing the small granules with medicinal talcum powder, medicinal silicon dioxide, magnesium stearate and other raw materials according to a certain weight ratio, and tabletting to form the cough-relieving tablet. The invention effectively improves the hardness and stability of the Keke tablet, greatly reduces the phenomena of incapability of coating films, poor stability, unqualified detection and the like caused by insufficient hardness, splintering, loose tablets and rough surface of the Keke tablet in the production, transportation and storage processes of the preparation, ensures the operability of the Keke tablet in production and the performance stability of the product in the effective period, and has simple and feasible preparation process and low production cost.

Description

a cough tablet

【Technical field】

The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a Keke tablet for treating cough and shortness of breath and a preparation method thereof. the

【Background technique】

Keke Tablets is a Chinese patent medicine with the functions of relieving cough, relieving asthma and eliminating phlegm. It is used for the treatment of cough and shortness of breath. Composition of traditional Chinese medicine. The existing Keke tablet preparation method is to take ephedra and poppy shells and crush them into fine powder, sieve, and keep 45.8% fine powder for later use; add acidic aqueous solution (use 10% hydrochloric acid solution to adjust the pH to about 5) and decoct the remaining coarse powder Second time, add water 10 times for the first time, add water 8 times for the second time, 2 hours each time, filter, adjust the pH value of the filtrate to 7 with 10% sodium hydroxide solution, and prepare the liquid medicine for later use; For the first time, add 10 times of water for the first time, add 8 times of water for the second time, each time for 1 hour, filter, combine the filtrate with the above solution, concentrate to a thick paste with a relative density of 1.20-1.25 (measured at 60°C), add ephedra and poppy Shell fine powder, mixed evenly, dried at 60-70°C, crushed into coarse powder, passed through a 40-mesh sieve, to obtain dry cream powder extracted from medicinal materials; then add appropriate amount of powdered sugar and magnesium stearate, mix well, and press into 1000 tablets, Film-coated, that is. The drug has been widely used in the treatment of cough and shortness of breath due to its good curative effect and convenient administration. The proportion in every Keke Tablet is 61.1%. The obtained plain tablet (the plain tablet is the tablet before the film coating) is very prone to poor hardness, easy to split, loose Problems such as unresolved, unable to be film-coated or surface rough after film-coating, so that the existing Keke tablets often have problems such as splits, poor stability, and unqualified testing within the validity period, which are difficult to be accepted by manufacturers and consumers . the

【Content of invention】

The purpose of the present invention is to address the above existing problems, to provide a Keke tablet that can effectively improve the hardness and stability of the Keke tablet, prevent its splits and loose tablets, and make the prepared plain tablet meet the requirements of the film coating and the Keke tablet. its preparation method. the

Technical scheme of the present invention is as follows:

The Keke Tablets of the present invention, its components include medicinal material extraction dry paste powder, sucrose powder, medicinal talcum powder, medicinal silicon dioxide, medicinal magnesium stearate, and is characterized in that it also includes a concentration of 20-95 % medicinal alcohol;

Wherein, the weight ratio of the above-mentioned components for every 1000 above-mentioned Keke tablets prepared is:

Medicinal extract dry paste powder 192～498g Sucrose powder 9.5～315.8g

Medicinal talcum powder 13.3～18g  Medicinal silica 13.3～18g

Medicinal magnesium stearate 0.89～1.21g 20-95% medicinal alcohol 4.7～156.6g;

The optimum weight ratio of each of the above components is:

Medicinal extract dry cream powder 437g Sucrose powder 70.2g

Medicinal talcum powder 15.7g Medicinal silica 15.7g

Medicinal magnesium stearate 1.05g 70% medicinal alcohol 34.8g;

The preparation method of Keke tablet of the present invention comprises the following steps:

(1), put a certain weight of sucrose powder in the high-efficiency mixing granulator, add a certain weight of 20-95% medicinal alcohol, and start the machine to mix evenly. the

(2), add a certain weight of medicinal material extraction dry paste powder into the above-mentioned high-efficiency mixing granulator and mix with the mixture of sucrose and 20-95% medicinal alcohol, and simultaneously start the machine and the granulation cutter for granulation ( granules (i.e. made into granules), so that all the materials form small granules that use sucrose containing 20-95% medicinal alcohol as the crystal nucleus to extract dry cream powder from outsourcing medicinal materials. the

(3), the above-mentioned granulated material is taken out, and passed through a 18-mesh steel screen by a swinging granulator. the

(4), the above-mentioned material passing through the 18-mesh steel screen is moved into the three-dimensional mixer, and a certain weight of medicinal talcum powder, medicinal silicon dioxide, and medicinal magnesium stearate are added to the three-dimensional mixer with the above-mentioned materials Mix evenly, and press into tablets with a tablet machine to obtain Keke Tablets Tablets. the

Wherein, the sucrose powder used in the above step (1) needs to be pulverized and passed through a 100-mesh sieve before feeding. the

In the present invention, because a certain weight of sucrose powder is placed in a high-efficiency mixing granulator, a certain weight of 20-95% medicinal alcohol is added and mixed evenly, so that the sucrose powder is in a wet state and contains the 20-95% alcohol. A small amount of water, when adding the dry paste powder of medicinal material extraction to the high-efficiency mixing granulator to start the machine to mix and open the granulation cutter, countless small particles of the dry paste powder of the outsourced medicinal material extraction can be formed with moist sucrose particles as crystal nuclei. Because the sucrose crystal nuclei inside the granules contain a small amount of water, the granules are dry on the outside and wet on the inside. When the granules enter the mold of the tablet machine for tableting, the granules are pressed by the upper punch and the lower punch of the tablet machine in the mold. Under the action of pressure, the sucrose crystal nuclei in the granules release a small amount of water, which causes the dry paste powder on the outer layer of the granules to be wetted by water, thereby causing the viscosity of the dry paste powder extracted from medicinal materials, making the compressed granules and granules The water bridge formed by this viscosity and the water released between the particles (the water bridge is a bridge-like structure formed by the water released between the particles and the particles, including certain substances passing through Bonding effect of water) tightly bonded together, so that the plain tablets obtained by tableting have high hardness, smooth and delicate surface, not easy to split and loose, and fully meet the requirements of film coating, thus effectively improving the stability of Keke Tablets It greatly reduces the occurrence of phenomena such as incapability of film coating, poor stability, and unqualified testing caused by factors such as insufficient tablet hardness, splits, loose tablets, and rough surfaces during production, transportation, and storage of the preparation, ensuring that the present invention The operability of the Keke Tablet during production and the performance stability of the product within the valid period, and its preparation process is simple, easy to implement and low in production cost. the

【Detailed ways】

Below in conjunction with specific embodiment the present invention is described in further detail:

The Keke Tablets of the present invention, its components include medicinal material extraction dry cream powder, sucrose powder, medicinal talcum powder, medicinal silicon dioxide, medicinal magnesium stearate, and medicinal alcohol. the

The concentration of medicinal alcohol is 20-95%, that is, the volume percentage of alcohol in medicinal alcohol is 20-95%. the

Wherein, the weight ratio of each component in every 1000 above-mentioned Keke Tablets is:

Medicinal extract dry cream powder 192～498g Sucrose powder 9.5～315.8g

Medicinal talcum powder 13.3～18g Medicinal silicon dioxide 13.3～18g

Medicinal magnesium stearate 0.89～1.21g 20-95% medicinal alcohol 4.7～156.6g

The optimum weight ratio of each of the above components is:

Medicinal extract dry cream powder 437g Sucrose powder 70.2g

Medicinal talcum powder 15.7g Medicinal silicon dioxide 15.7g

Medicinal magnesium stearate 1.05g 70% medicinal alcohol 34.8g

The preparation method of Keke tablet of the present invention comprises the following steps:

(1), put a certain weight of sucrose powder in the high-efficiency mixing granulator, add a certain weight of 20-95% medicinal alcohol, and start the machine to mix evenly. the

(2), add a certain weight of medicinal material extraction dry paste powder into the above-mentioned high-efficiency mixing granulator and mix with the mixture of sucrose and 20-95% medicinal alcohol, and simultaneously start the machine and the granulation cutter for granulation ( (i.e., granules are made into granules), so that all the materials form numerous small granules that use sucrose containing 20-95% medicinal alcohol as the crystal nucleus to extract dry cream powder from outsourcing medicinal materials. the

(3), the above-mentioned granulated material is taken out, and passed through a 18-mesh steel screen by a swinging granulator. the

(4), the above-mentioned material passing through the 18-mesh steel screen is moved into the three-dimensional mixer, and a certain weight of medicinal talcum powder, medicinal silicon dioxide, and medicinal magnesium stearate are added to the three-dimensional mixer with the above-mentioned materials Mix evenly, and press into tablets with a tablet machine to obtain Keke Tablets Tablets. the

Wherein, the sucrose powder used in the above step (1) needs to be pulverized and passed through a 100-mesh sieve before feeding. the

Example 1: First put 315.8g of sucrose powder in the high-efficiency mixing granulator, add 156.6g of 95% medicinal alcohol, start the machine and mix evenly; add 192g of medicinal material extraction dry paste powder into the above-mentioned high-efficiency mixing granulator Mix with a mixture of sucrose and 95% medicinal alcohol, and at the same time start the machine and granulation cutter to granulate (i.e. make granules), so that all materials are formed and the sucrose containing 95% medicinal alcohol is used as the crystal nucleus to extract medicinal materials outsourced Small particles of dry paste powder; take out the above-mentioned granulated material, and pass through a 18-mesh steel screen through a swing granulator; move the above-mentioned material that has passed through the 18-mesh steel screen into a three-dimensional mixer, and mix 15.7g of the medicine Add talcum powder, 15.7g of medicinal silicon dioxide, and 1.05g of medicinal magnesium stearate into a three-dimensional mixer and mix with the above-mentioned materials evenly, and press into tablets with a tablet machine to obtain 1000 grams of cough tablets. the

Example 2: First put 70.2g of sucrose powder in the high-efficiency mixing granulator, add 34.8g of 70% medicinal alcohol, start the machine and mix evenly; add 437g of medicinal material extraction dry paste powder into the above-mentioned high-efficiency mixing granulator Mix with a mixture of sucrose and 70% medicinal alcohol, and at the same time start the machine and granulating cutter to granulate, so that all materials form small particles of dry cream powder extracted from outsourcing medicinal materials with 70% medicinal alcohol as the crystal nucleus The above-mentioned material through granulation is taken out, and crosses 18 mesh steel screens by a swinging granulator; the above-mentioned material passing through 18 mesh steel screens is moved to a three-dimensional mixer, and 15.7g of medicinal talcum powder, 15.7g The medicinal silica of 1.05g and the medicinal magnesium stearate of 1.05g are added in the three-dimensional mixer and mixed evenly with the above-mentioned materials, and are pressed into tablets with a tablet machine to obtain 1000 grams of cough tablets. the

Example 3: first put 9.5g of sucrose powder in the high-efficiency mixing granulator, add 4.7g of 25% medicinal alcohol, start the machine and mix evenly; add 498g of medicinal material extraction dry paste powder into the above-mentioned high-efficiency mixing granulator Mix with a mixture of sucrose and 25% medicinal alcohol, and at the same time start the machine and granulating cutter to granulate, so that all the materials form small particles of dry paste powder extracted from outsourcing medicinal materials with 25% medicinal alcohol as the crystal nucleus. The above-mentioned material through granulation is taken out, and crosses 18 mesh steel screens by a swinging granulator; the above-mentioned material passing through 18 mesh steel screens is moved to a three-dimensional mixer, and 15.7g of medicinal talcum powder, 15.7g The medicinal silica of 1.05g and the medicinal magnesium stearate of 1.05g are added in the three-dimensional mixer and mixed evenly with the above-mentioned materials, and are pressed into tablets with a tablet machine to obtain 1000 grams of cough tablets. the

In order to demonstrate the hardness and stability of the Keke Tablets of the present invention, the Keke Tablets prepared in Example 1, Example 2, and Example 3 were respectively compared with the Keke Tablets produced by the prior art. Hardness test, friability test, film coating test, constant temperature acceleration test, destructive test, the results show that compared with the existing Keke Tablets, Keke Tablets of the present invention exhibit higher hardness and considerable stability, The effect after film coating is very ideal, the surface is smooth, delicate and beautiful. the

Wherein, the result of hardness test is as follows: the technology production hardness of prior art:＜5Kgf; Adopt the technology production hardness of the present invention:＞12Kgf (Kgf is the kilogram force, is equivalent to such a large force of the suffered gravity of a kilogram , that is, a force of 9.8N); the results of the friability test are as follows: the friability produced by the process of the prior art: > 3%; the friability produced by the process of the present invention: <0.3%. the

Claims (3)

1. cough-relieving tablets, prescription is made up of Herba Ephedrae, Pericarpium Papaveris, Radix Glycyrrhizae, Semen Armeniacae Amarum, Radix Platycodonis, Semen Raphani, Gypsum Fibrosum seven flavor Chinese medicines, its component comprises medicinal material extract dried cream powder, cane sugar powder, medicinal Pulvis Talci, medicinal silicon dioxide, medicinal magnesium stearate, and it is characterized in that also including concentration is the 20-95% medicinal alcohol; The weight proportion of above-mentioned each component in per 1000 tablets of tablets is:

Medicinal material extract dried cream powder 192～498g cane sugar powder 9.5～315.8g

The medicinal silica 1 3.3～18g of medicinal Pulvis Talci 13.3～18g

Medicinal magnesium stearate 0.89～1.21g 20-95% medicinal alcohol 4.7～156.6g;

The preparation method of described cough-relieving tablets may further comprise the steps:

(1), the cane sugar powder of constant weight is put in the high efficient mixed granulator 20-95% medicinal alcohol of adding constant weight, the mix homogeneously of machining;

(2), the medicinal material extract dried cream powder of constant weight is joined in the above-mentioned high efficient mixed granulator mix with the mixture of sucrose, 20-95% medicinal alcohol, machine simultaneously and the cutting knife of granulating is granulated, it is the granule of nucleus outsourcing medicinal material extract dried cream powder that whole materials are formed with the sucrose that contains the 20-95% medicinal alcohol;

(3), take out through the material of granulating, cross 18 order steel screen clothes by oscillating granulator with above-mentioned;

(4), above-mentioned material by 18 order steel screen clothes is moved in the three-dimensional mixer, with even in the medicinal Pulvis Talci of constant weight, medicinal silicon dioxide, the medicinal magnesium stearate adding three-dimensional mixer, promptly get the plain sheet of cough-relieving tablets with the tablet machine tabletting with above-mentioned mixing of materials.

2. cough-relieving tablets according to claim 1 is characterized in that the weight proportion optimum of above-mentioned each component is:

Medicinal material extract dried cream powder 437g cane sugar powder 70.2g

The medicinal silica 1 5.7g of medicinal Pulvis Talci 15.7g

Medicinal magnesium stearate 1.05g 70% medicinal alcohol 34.8g.

3. cough-relieving tablets according to claim 1 is characterized in that need pulverizing 100 mesh sieves before used cane sugar powder feeds intake in the above-mentioned steps (1).