CN101444495B - A kind of preparation method of vitamin E microcapsule - Google Patents
A kind of preparation method of vitamin E microcapsule Download PDFInfo
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- CN101444495B CN101444495B CN2008102426713A CN200810242671A CN101444495B CN 101444495 B CN101444495 B CN 101444495B CN 2008102426713 A CN2008102426713 A CN 2008102426713A CN 200810242671 A CN200810242671 A CN 200810242671A CN 101444495 B CN101444495 B CN 101444495B
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract description 134
- 229930003427 Vitamin E Natural products 0.000 title claims abstract description 66
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title claims abstract description 66
- 239000011709 vitamin E Substances 0.000 title claims abstract description 66
- 235000019165 vitamin E Nutrition 0.000 title claims abstract description 66
- 229940046009 vitamin E Drugs 0.000 title claims abstract description 66
- 239000003094 microcapsule Substances 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 27
- 229920001661 Chitosan Polymers 0.000 claims abstract description 23
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 21
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 21
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 15
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims abstract description 12
- 239000002131 composite material Substances 0.000 claims abstract description 12
- 229940083466 soybean lecithin Drugs 0.000 claims abstract description 12
- 238000001694 spray drying Methods 0.000 claims abstract description 11
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 35
- 239000000839 emulsion Substances 0.000 claims description 34
- 238000003756 stirring Methods 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 14
- 238000005516 engineering process Methods 0.000 claims description 12
- 239000007974 sodium acetate buffer Substances 0.000 claims description 12
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 claims description 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- 238000004945 emulsification Methods 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 230000006196 deacetylation Effects 0.000 claims description 2
- 238000003381 deacetylation reaction Methods 0.000 claims description 2
- 229930003799 tocopherol Natural products 0.000 claims description 2
- 229960001295 tocopherol Drugs 0.000 claims description 2
- 239000011732 tocopherol Substances 0.000 claims description 2
- 235000010384 tocopherol Nutrition 0.000 claims description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 2
- 239000011162 core material Substances 0.000 claims 3
- 238000000034 method Methods 0.000 abstract description 19
- 239000000126 substance Substances 0.000 abstract description 6
- 230000014759 maintenance of location Effects 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 4
- 235000013361 beverage Nutrition 0.000 abstract description 3
- 235000015895 biscuits Nutrition 0.000 abstract description 3
- 235000008429 bread Nutrition 0.000 abstract description 3
- 230000007613 environmental effect Effects 0.000 abstract description 3
- 235000013402 health food Nutrition 0.000 abstract description 3
- 235000011888 snacks Nutrition 0.000 abstract description 3
- 230000000975 bioactive effect Effects 0.000 abstract description 2
- 235000013373 food additive Nutrition 0.000 abstract description 2
- 239000002778 food additive Substances 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 2
- 238000013270 controlled release Methods 0.000 abstract 1
- 235000014106 fortified food Nutrition 0.000 abstract 1
- 238000005303 weighing Methods 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 10
- 235000013305 food Nutrition 0.000 description 9
- 230000001804 emulsifying effect Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000872 buffer Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 239000002932 luster Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- GUOCOOQWZHQBJI-UHFFFAOYSA-N 4-oct-7-enoxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)OCCCCCCC=C GUOCOOQWZHQBJI-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicinal Preparation (AREA)
Abstract
一种维生素E微胶囊的制备方法，属于食品添加剂和生物活性物质控制释放的微胶囊制备技术领域。本发明的目的在于提供一种维生素E微胶囊的制备方法，提高维生素E的稳定性，扩大其应用范围。本方法以壳聚糖和麦芽糊精为壁材，以大豆卵磷脂(P粉)和Tween-80为复合乳化剂，通过喷雾干燥的方法制备维生素E微胶囊，所得的维生素E微胶囊产品的包埋率可达到92.45％、保留率可达到91.73％，水分在3％以下，可用于面包或点心制品、饮料、饼干类、保健食品以及营养强化食品等方面，具有广泛的应用前景。本方法成本低廉、工艺简单、符合环保和实用要求。The invention discloses a method for preparing vitamin E microcapsules, belonging to the technical field of microcapsule preparations for controlled release of food additives and bioactive substances. The purpose of the present invention is to provide a preparation method of vitamin E microcapsules, improve the stability of vitamin E, and expand its application range. In this method, chitosan and maltodextrin are used as wall materials, soybean lecithin (P powder) and Tween-80 are used as composite emulsifiers, and vitamin E microcapsules are prepared by spray drying. The embedding rate can reach 92.45%, the retention rate can reach 91.73%, and the water content is below 3%. It can be used in bread or snack products, beverages, biscuits, health food and nutritionally fortified food, etc., and has a wide application prospect. The method has the advantages of low cost, simple process, and meets environmental protection and practical requirements.
Description
Technical field
A kind of preparation method of Vitamin E contained micro capsule belongs to the microcapsule preparing technical field of food additive and bioactive substance sustained release.
Background technology
Vitamin E is a class nutritional labeling of needed by human; it is a kind of strong effectively free radical scavenger; can protect body cell film and life macromolecule to exempt from the attack of free radical; be the Natural antioxidant of a class highly effective and safe, at slow down aging, prevent and treat cardiovascular disease, anti-tumor aspect has good effect.No matter natural Vitamin E still on safety all is better than synthesising complex E at nutrition, physiologically active.Along with going deep into of threpsology and pathological research, the how new function of vitamin E is found constantly and is confirmed that people are increasing to the demand of vitamin E, and its effect more and more is subject to people's attention.
Vitamin E belongs to oil-soluble heat-sensitive materials, be difficult to water-soluble substances miscible, make it be difficult to add to uniformly in the water solublity food product, and ultraviolet, alkali and oxygen etc. can both destroy vitamin E, so will seal usually, keep in Dark Place, limit the application of vitamin E so greatly in food industry.Microcapsule technology is to protect core to avoid adverse environmental factors such as influences such as light, oxygen with filmogen embedding solid, liquid or gas; improve the stability and the shelf life of product with this; the range of application of expansion core, and a kind of technology of control core release.It can change physical form, protect sensitive composition, isolate active substance, reduce volatility, make immiscible composition mix and reduce the toxicity of some chemical addition agent, the application of having succeeded in many fields such as food, chemical industry, medicine, biotechnology.In food industry, manyly, technology barrier is achieved by microcapsule technology owing to can not get development product, and make the quality of traditional product be greatly improved, for the exploitation of food industry new and high technology has represented good prospect.Vitamin E is made the micro encapsulation vitamin E with methods such as spray dryinges, can keep the intrinsic property of vitamin E, can overcome its easy oxidation and water-fast shortcoming again.The Vitamin E contained micro capsule product can be used for bread or aspects such as snack food product, beverage, Biscuits, health food and nourishing reinforced food, has broad application prospects.
A lot of researchs about Vitamin E contained micro capsule have been arranged both at home and abroad.Patent publication No. is CN1927188A, invent a kind of preparation method of voltage endurance vitamin E microcapsule, percentage by weight between its component and the component is: vitamin E oil 50%～70%, capsule material 1%～25%, auxiliary capsule material 5%～30%, octenyl succinate starch 10%～30%, fluidizer 0.5%～2%, the mechanical strength of gained microcapsule is enough to satisfy the tabletting requirement, and fuel load can be up to 70%.Patent publication No. is CN1568969A, invent a kind of preparation method and purposes of vitamin E clathrate, by cyclodextrin or cyclodextrin derivative vitamin E is carried out enclose, preferred HP-, the content of vitamin E of the enclose material of gained is below 10%.The above patent of comparing, the present invention with wide material sources, chitosan with low cost and maltodextrin as the wall material, do not add auxiliary capsule material, adopt biphase emulsion process, prepare the Vitamin E contained micro capsule product by spray-dired method, technology is simple, helps large-scale industrial production, and the vitamin E carrying capacity is greater than 30%.Complex coacervation also is a kind of means of Vitamin E contained micro capsuleization in addition, but the used common cost of wall material is higher, the complexity that technology also compares, and used cross-linking agent is also often toxic.Cross-linking method also is a kind of method of Vitamin E contained micro capsuleization, and at present, external having much prepares fatsoluble vitamin microcapsule patent with cross-linking method, but the method technology is comparatively complicated, and cross-linking process needs Consideration more, and this method is also being updated.Along with microcapsule research deepens continuously, it is also more and more to can be used for the Vitamin E contained micro capsule method, but spray drying method is still most popular method at present.
Summary of the invention
The object of the present invention is to provide the preparation method of a kind of process safety Vitamin E contained micro capsule simple, with low cost, improve the stability of vitamin E, control its dispose procedure, enlarge the scope of its application.
Technical scheme of the present invention: with the vitamin E is core, with chitosan and maltodextrin is the wall material, is compound emulsifying agent with soybean lecithin and Tween-80, by high-pressure emulsification and centrifugal spray drying technology, prepare pulverous Vitamin E contained micro capsule product, preparation process is as follows:
(1) chitosan is dissolved in the acetic acid-sodium acetate buffer of 0.1mol/L, pH3.0～4.0, the formation mass fraction is 1.5%～2.25% clear solution;
(2) maltodextrin is dissolved in the acetic acid-sodium acetate buffer of 0.1mol/L, pH3.0～4.0, the formation mass fraction is 37.5%～50% solution;
(3) soybean lecithin and Tween-80 are dissolved in the acetic acid-sodium acetate buffer of 0.1mol/L, pH3.0～4.0 according to 4: 2 mass ratio as compound emulsifying agent, forming mass fraction is 1.5%～1.75% composite emulsifying agent solution;
(4) vitamin E is added in the composite emulsifying agent solution that step (3) obtains according to the mass ratio with compound emulsifying agent 1: 0.25～0.35, stirring (700～1000rpm) time uniform core emulsions of formation;
(5) with the chitosan solution of step (1), be added to while stirring in the core emulsion that step (4) obtains, high speed shear emulsifying again (10000～13000rpm, 3～5min) obtain the elementary emulsion of microcapsule;
(6) maltodextrin solution of step (2) is added to while stirring in the elementary emulsion of microcapsule that step (5) obtains, and high speed shear emulsifying again (10000～13000rpm, 3～5min) obtain final microcapsule emulsion; Control that the related component mass percent is in the final microcapsule emulsion: vitamin E 5%～6.5%, chitosan 0.4%～0.6%, maltodextrin 15%～20% and compound emulsifying agent 1.5%～1.75%;
(7) with the microcapsule emulsion of step (6) gained, through 40～50MPa, homogenizing 3 times carries out spray drying then, promptly gets the Vitamin E contained micro capsule powder.The spray drying parameter is: 180 ℃ of intake air temperatures, and 80 ℃ of air outlet temperature, charging under the room temperature, flow velocity is 1～2L/h.
The deacetylation of used chitosan is 80%～85%.
The DE value of used maltodextrin is between 15 to 20.
Used soybean lecithin is Powdered, and acetone insoluble matter wherein is 97%, and HLB is 7.
Used vitamin E is a natural Vitamin E, its total tocopherol content 〉=90%.
Beneficial effect of the present invention: the Vitamin E contained micro capsule that adopts said method to make, its characteristics are: vitamin E is added in the compound emulsion agent solution, after high-speed stirred, emulsifying agent can be distributed on the surface of vitamin E rapidly, when adding chitosan solution, because under acid condition, the chitosan molecule surface has a large amount of positive charges, under electrostatic effect, chitosan molecule can be adsorbed the surface that is dispersed in vitamin E, when adding maltodextrin solution again, be equivalent to vitamin E oil has been carried out secondary embedding, play the effect of wrapping up and filling out envelope, and in whole embedding process, because it is more stable that vitamin E is under the acid condition, the loss of vitamin E seldom in therefore producing.
The preparation method of Vitamin E contained micro capsule provided by the invention is with low cost, technology simple, meet environmental protection and practical requirement.Used chitosan, wide material sources and cheap, it has unique physiology and chemical characteristic simultaneously, nontoxic, excellent biological compatibility, biodegradability arranged, it is a kind of good biomaterial, having good film property again, is a kind of ideal microcapsule wall material, and same used maltodextrin also is cost-effective wall material.Used emulsifying agent soybean lecithin and Tween-80 do not have toxicity to human body, and soybean lecithin has very high nutritive value, and wide material sources, cheap.Vitamin E behind the micro encapsulation can keep the intrinsic property of vitamin E, can overcome its easy oxidation and water-fast shortcoming again.The Vitamin E contained micro capsule of gained of the present invention, embedding rate can reach more than 90%, retention rate also can reach more than 90% and the moisture of product below 3%, it can be used for bread or aspects such as snack food product, beverage, Biscuits, health food and nourishing reinforced food, has broad application prospects.
Specific embodiments
Embodiment 1: the preparation method of Vitamin E contained micro capsule, it comprises the steps:
(1) take by weighing the 2.4g chitosan and be dissolved in the acetic acid-sodium acetate buffer of 0.1mol/L, pH3.0～4.0, the formation mass fraction is 1.5% clear solution;
(2) take by weighing the 120g maltodextrin and be dissolved in acetic acid-sodium acetate buffer, the formation mass fraction is 50% solution;
(3) take by weighing the 6g soybean lecithin and 3g Tween-80 is dissolved in buffer as compound emulsifying agent, forming mass fraction is 1.5% composite emulsifying agent solution;
(4) take by weighing the 30g vitamin E oil and add in the composite emulsifying agent solution that step (3) obtains, the mass ratio of compound emulsifying agent and vitamin E oil is 0.3: 1, is stirring (700～1000rpm) time uniform core emulsions of formation;
(5) with 1.5% chitosan solution of step (1), be added to while stirring in the core emulsion that step (4) obtains, high speed shear emulsifying again (10000～13000rpm, 3～5min) obtain the elementary emulsion of microcapsule;
(6) 50% maltodextrin solution of step (2) is added to while stirring in the elementary emulsion of microcapsule that step (5) obtains, and high speed shear emulsifying again (10000～13000rpm, 3～5min) obtain final microcapsule emulsion;
(7) with the microcapsule emulsion of step (6) gained, through 40～50MPa, homogenizing 3 times carries out spray drying then, and the inlet temperature of spray dryer is that 180 ℃, outlet temperature are 80 ℃, charging under the room temperature, and the feed liquid flow velocity is 1～2L/h.
The microcapsule product of gained is creamy white, and has color and luster preferably, and embedding rate is 92.45%, and retention rate is 85.88%, and moisture is 2.34%.
Embodiment 2: the preparation method of vitamin E oil microcapsule, it comprises the steps:
(1) take by weighing the 3.6g chitosan and be dissolved in the acetic acid-sodium acetate buffer of 0.1mol/L, pH3.0～4.0, the formation mass fraction is 2.25% clear solution.
(2) take by weighing the 90g maltodextrin and be dissolved in acetic acid-sodium acetate buffer, the formation mass fraction is 37.5% solution.
(3) take by weighing the 7g soybean lecithin and 3.5g Tween-80 is dissolved in buffer as compound emulsifying agent, forming mass fraction is 1.75% composite emulsifying agent solution.
(4) take by weighing the 30g vitamin E oil and add in the composite emulsifying agent solution that step (3) obtains, the mass ratio of compound emulsifying agent and vitamin E oil is 0.35: 1, and (700～1000rpm) form uniform core emulsion stirring.
(5) with 2.25% chitosan solution of step (1), be added to while stirring in the core emulsion that step (4) obtains, (10000～13000rpm, 3～5min) obtain the elementary emulsion of microcapsule in high speed shear emulsifying again.
(6) 37.5% maltodextrin solution of step (2) is added to while stirring in the elementary emulsion of microcapsule that step (5) obtains, (10000～13000rpm, 3～5min) obtain final microcapsule emulsion in high speed shear emulsifying again.
(7) with the microcapsule emulsion of step (6) gained, through 40～50MPa, homogenizing 3 times carries out spray drying then, and the inlet temperature of spray dryer is that 180 ℃, outlet temperature are 80 ℃, charging under the room temperature, and the feed liquid flow velocity is 1～2L/h.
The microcapsule product of gained is creamy white, and has color and luster preferably, and embedding rate is 79.64%, and is expected to surpass 80%, and retention rate is 89.90%, and moisture is 2.38%.
Embodiment 3: the preparation method of vitamin E oil microcapsule, it comprises the steps:
(1) take by weighing the 3.6g chitosan and be dissolved in the acetic acid-sodium acetate buffer of 0.1mol/L, pH3.0～4.0, the formation mass fraction is 2.25% clear solution.
(2) take by weighing the 120g maltodextrin and be dissolved in acetic acid-sodium acetate buffer, the formation mass fraction is 50% solution.
(3) take by weighing 6.5g soybean lecithin and 3.25gTween-80 and be dissolved in buffer as compound emulsifying agent, forming mass fraction is 1.625% composite emulsifying agent solution.
(4) take by weighing the 39g vitamin E oil and add in the composite emulsifying agent solution that step (3) obtains, the mass ratio of compound emulsifying agent and vitamin E oil is 0.25: I, (700～1000rpm) form uniform core emulsion stirring.
(5) with 2.25% chitosan solution of step (1), be added to while stirring in the core emulsion that step (4) obtains, (10000～13000rpm, 3～5min) obtain the elementary emulsion of microcapsule in high speed shear emulsifying again.
(6) 50% maltodextrin solution of step (2) is added to while stirring in the elementary emulsion of microcapsule that step (5) obtains, (10000～13000rpm, 3～5min) obtain final microcapsule emulsion in high speed shear emulsifying again.
(7) with the microcapsule emulsion of step (6) gained, through 40～50MPa, homogenizing 3 times carries out spray drying then, and the inlet temperature of spray dryer is that 180 ℃, outlet temperature are 80 ℃, charging under the room temperature, and the feed liquid flow velocity is 1～2L/h.
The microcapsule product of gained is creamy white, and has color and luster preferably, and embedding rate is 89.02%, and is expected to surpass 90%, and retention rate is 91.73%, and moisture is 2.67%.
Claims (6)
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101972619A (en) * | 2010-09-01 | 2011-02-16 | 浙江中烟工业有限责任公司 | Preparation method of menthol microcapsules |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2364600A1 (en) * | 2010-02-18 | 2011-09-14 | Nestec S.A. | Liquid-filled chitosan-anionic liposoluble capsule dispsersions |
| CN102106480B (en) * | 2011-01-26 | 2012-07-11 | 广东省农业科学院畜牧研究所 | B family crystalline vitamin microcapsules and method for preparing the microcapsules by spray-drying method |
| CN102953269B (en) * | 2011-08-30 | 2014-10-15 | 杨建� | Wax ester microcapsules and spinning waxing method thereof |
| CN103520005B (en) * | 2013-10-17 | 2015-09-02 | 天津郁美净集团有限公司 | A kind of mosquito repellent composition microcapsule and preparation method thereof and application |
| CN103549157B (en) * | 2013-11-14 | 2015-09-02 | 厦门金达威集团股份有限公司 | Scold the preparation method of water type vitamin microcapsule |
| CN103735468B (en) * | 2014-01-22 | 2015-10-14 | 天津郁美净集团有限公司 | A kind of cosmetics containing mosquito repellent composition microcapsule |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879609A (en) * | 2006-05-10 | 2006-12-20 | 浙江大学 | A method for preparing silk fibroin Vitamin E contained micro capsule |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879609A (en) * | 2006-05-10 | 2006-12-20 | 浙江大学 | A method for preparing silk fibroin Vitamin E contained micro capsule |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972619A (en) * | 2010-09-01 | 2011-02-16 | 浙江中烟工业有限责任公司 | Preparation method of menthol microcapsules |
| CN101972619B (en) * | 2010-09-01 | 2012-05-23 | 浙江中烟工业有限责任公司 | Preparation method of menthol microcapsules |
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| CN101444495A (en) | 2009-06-03 |
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