CN109674766A - A kind of slow-release beta-carotin microcapsule powder and preparation method thereof - Google Patents
A kind of slow-release beta-carotin microcapsule powder and preparation method thereof Download PDFInfo
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- CN109674766A CN109674766A CN201910032309.1A CN201910032309A CN109674766A CN 109674766 A CN109674766 A CN 109674766A CN 201910032309 A CN201910032309 A CN 201910032309A CN 109674766 A CN109674766 A CN 109674766A
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- microcapsule powder
- beta
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- lotion
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- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 title claims abstract description 66
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 title claims abstract description 66
- 239000003094 microcapsule Substances 0.000 title claims abstract description 43
- 239000000843 powder Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 235000013734 beta-carotene Nutrition 0.000 claims abstract description 39
- 239000011648 beta-carotene Substances 0.000 claims abstract description 39
- 239000001814 pectin Substances 0.000 claims abstract description 39
- 235000010987 pectin Nutrition 0.000 claims abstract description 39
- 229920001277 pectin Polymers 0.000 claims abstract description 39
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims abstract description 38
- 229960002747 betacarotene Drugs 0.000 claims abstract description 38
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 36
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 36
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 36
- 239000013078 crystal Substances 0.000 claims abstract description 16
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims abstract description 12
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 9
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 8
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 8
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 8
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 8
- 239000008158 vegetable oil Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000006210 lotion Substances 0.000 claims description 75
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 75
- 239000004816 latex Substances 0.000 claims description 36
- 229920000126 latex Polymers 0.000 claims description 36
- 239000012153 distilled water Substances 0.000 claims description 34
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 28
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical group C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 claims description 24
- 239000007864 aqueous solution Substances 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 19
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 14
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 claims description 12
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 claims description 12
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 claims description 12
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- 235000019486 Sunflower oil Nutrition 0.000 claims description 10
- 239000002600 sunflower oil Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 102000007544 Whey Proteins Human genes 0.000 claims description 7
- 108010046377 Whey Proteins Proteins 0.000 claims description 7
- 239000005018 casein Substances 0.000 claims description 7
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 7
- 235000021240 caseins Nutrition 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 235000021119 whey protein Nutrition 0.000 claims description 7
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 239000011709 vitamin E Substances 0.000 claims description 5
- 235000019165 vitamin E Nutrition 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 102000008192 Lactoglobulins Human genes 0.000 claims description 4
- 108010060630 Lactoglobulins Proteins 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 claims description 3
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 3
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 3
- 244000269722 Thea sinensis Species 0.000 claims description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 3
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 3
- UKGRTCZMPQERFQ-UHFFFAOYSA-N octadecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)C(C)O UKGRTCZMPQERFQ-UHFFFAOYSA-N 0.000 claims description 3
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 3
- 235000013824 polyphenols Nutrition 0.000 claims description 3
- 235000019155 vitamin A Nutrition 0.000 claims description 3
- 239000011719 vitamin A Substances 0.000 claims description 3
- 229940045997 vitamin a Drugs 0.000 claims description 3
- 239000002285 corn oil Substances 0.000 claims description 2
- 235000005687 corn oil Nutrition 0.000 claims description 2
- 239000007789 gas Substances 0.000 claims description 2
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 230000009471 action Effects 0.000 abstract description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 239000001301 oxygen Substances 0.000 abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 abstract description 3
- 239000002699 waste material Substances 0.000 abstract description 3
- 238000001879 gelation Methods 0.000 abstract description 2
- 239000003960 organic solvent Substances 0.000 abstract description 2
- 230000001681 protective effect Effects 0.000 abstract description 2
- 210000002784 stomach Anatomy 0.000 abstract description 2
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- 239000012530 fluid Substances 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- 230000000968 intestinal effect Effects 0.000 description 7
- 230000007775 late Effects 0.000 description 6
- 235000013305 food Nutrition 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 210000004051 gastric juice Anatomy 0.000 description 4
- -1 starch Chemical compound 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 235000013373 food additive Nutrition 0.000 description 3
- 239000002778 food additive Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000008351 acetate buffer Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 150000002460 imidazoles Chemical class 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical class CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 241000206575 Chondrus crispus Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 150000001579 beta-carotenes Chemical class 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
The invention discloses a kind of slow-release beta-carotin microcapsule powder and preparation method thereof, the percent mass proportioning of the microcapsule powder is formed are as follows: beta carotene crystal 0.5%~20%, antioxidant 0.01%~5%, emulsifier 0.01%~2%, vegetable oil 5%~50%, albumen 2%~20%, dipotassium hydrogen phosphate 0.2%~2%, pectin 1%~10%, maltodextrin add to 100%.The present invention passes through albumen and pectin double-layer embedment technique, pass through gelation and crosslinked action, achieve the purpose that hinder beta carotene release, discharge it hardly in stomach, after reaching enteron aisle, just the beta carotene being wrapped in wall material is slowly released, obtained beta-carotin microcapsule powder slow release effect is significant.The beta-carotin microcapsule powder that the present invention obtains is heat-resisting, light, oxygen, and embedding rate is high, and shelf life is long.The preparation process of beta-carotin microcapsule powder of the present invention does not use any organic solvent, and does not generate any waste in production process, belongs to environmentally protective production technology.
Description
Technical field
The present invention relates to a kind of slow-release beta-carotin microcapsule powders and preparation method thereof.
Background technique
Beta carotene is the Typical Representative in carotenoid family, is not only the important sources of internal vitamin A, and
And itself also has important physiological function to human body, it can prevent, delay and treat certain diseases, especially cancer,
The immune function of body can be also improved simultaneously.United States drug and food control office (FDA) confirmation this product safety, approval are used as food
The immediate constituent of product, cosmetics and drug.The United States Pharmacopeia of nineteen ninety formally records beta carotene.Beta carotene also conduct
Food additives and nutritional supplement are combined by FAO (Food and Agriculture Organization of the United Nation) (FAO) and the World Health Organization's (WHO) food additives
The Committee of Experts is recommended, and is considered that A class is outstanding and nourishing food additive.Beta carotene increasingly causes people at home
Concern and interest, it is studied very active.
Beta carotene is a kind of fat-soluble natural pigment, not soluble in water, fat and oil is slightly soluble in, in molecular structure
Polyene systems are easily degraded under the action of light, oxygen, heat, it also occur that isomerization.Therefore, beta carotene in actual production and
It is very restricted in, and the carrotene of crystal form is difficult to decompose and absorb in human body, to affect
Its bioavailability causes greatly to waste.
It mainly uses microcapsule embedded technology both at home and abroad at present, fat-soluble beta carotene is wrapped up, water is prepared into
Dissolubility beta-carotin microcapsule powder.The committed step of embedding techniques is to select emulsification and the preferable wall material of film-forming quality, at present
There is lot of documents to report the wall material for embedding beta carotene, including starch, protide (whey protein isolate, junket egg
White, beta lactoglobulin, gelatin etc.), carbohydrate (trehalose, pectin, carragheen, chitosan, Arabic gum etc.).The persons such as Hu little Ming
It is wall material with gelatin and sucrose, spray drying microencapsulation is carried out to beta carotene, beta-carotin microcapsule powder obtained is water-soluble
Property, dispersibility and stability are preferable.Xu Bo et al. selects converted starch and maltodextrin is wall material, and discovery is brilliant with beta carotene
Body is compared, and the beta carotene stability after microencapsulation is greatly improved.But only limitation improves β-Hu Luo for existing research
The water solubility and dispersibility of Bu Su, does not study the slow release effect of beta carotene.
Summary of the invention
The object of the present invention is to provide slow-release beta carotenes a kind of water-soluble and that dispersibility is high to delay microcapsule powder, and
The preparation method of the microcapsule powder.
For above-mentioned purpose, slow-release beta carotene of the present invention delays microcapsule powder by following percent mass proportionings
Raw material be made:
Slow-release beta-carotin microcapsule powder of the present invention is preferably made of the raw material of following percent mass proportionings:
Above-mentioned antioxidant is Rosmarinic acid, appoints in vitamin E, vitamin A, ascorbyl palmitate, tea polyphenols
The mixture of any one in the mixture for one or more of anticipating, preferably Rosmarinic acid, vitamin E or both.
Above-mentioned emulsifier is single bi-tristearin, diacetyl tartarate monoglyceride, stearyl lactate, food
Any one in grade tween or two or more mixtures, preferably single bi-tristearin.
Above-mentioned albumen is whey protein isolate, casein sodium, beta lactoglobulin, any one in gelatin.
Above-mentioned vegetable oil is miglyol 812, sunflower oil, any one in corn oil or two or more mixtures.
The preparation method of slow-release beta-carotin microcapsule powder of the present invention is made of following step:
1, oily phase is prepared
Beta carotene crystal, antioxidant and emulsifier are added in vegetable oil, stirred under nitrogen protection to solid
Body is completely dissolved, and obtains oily phase.
2, water phase is prepared
Albumen and dipotassium hydrogen phosphate are added in distilled water, in 50~70 DEG C of 2~12h of aquation, obtaining protein content is
The water phase of 0.01~0.5g/mL.
3, initial latex is prepared
It is mutually mixed oily with water phase, high speed shear, then homogeneous 2~3 times at 300~500MPa obtain initial latex.
4, two layers of lotion are prepared
Pectin is dissolved in distilled water, 2~4h is stirred at 50~70 DEG C, obtains the fruit that concentration is 0.02~0.2g/mL
Then aqueous pectin solution is mixed with initial latex, 1~8h is stirred at room temperature by glue solution, obtain two layers of lotion.
5, whole lotion is prepared
Maltodextrin is dissolved in distilled water, the maltodextrin aqueous solution that concentration is 0.2~3g/mL is obtained, then by wheat
Bud dextrin in aqueous solution is mixed with two layers of lotion, and 1~8h is stirred at room temperature, and obtains whole lotion；
6 spray drying
Whole lotion is spray-dried, 130~180 DEG C of inlet temperature, 90~120 DEG C of outlet temperature, obtains slow-release
Beta-carotin microcapsule powder.
In above-mentioned steps 1, beta carotene crystal, antioxidant and emulsifier are added in vegetable oil, preferably in nitrogen
50~200 DEG C of stirrings are completely dissolved to solid under gas shielded, obtain oily phase.
In above-mentioned steps 6, whole lotion is spray-dried, 150~160 DEG C of preferred inlet temperatures, outlet temperature 100~
110℃。
Beneficial effects of the present invention are as follows:
1, for the present invention by albumen and pectin double-layer embedment technique, selections pectin is second layer wall material, by gelation with
Crosslinked action achievees the purpose that hinder drug release, hardly discharge in stomach, after reaching enteron aisle, passes through the degradation of pectase
Effect, just releases the beta carotene being wrapped in wall material, obtained beta-carotin microcapsule powder slow release effect is significant.
2, the present invention uses albumen and pectin double-layer embedment technique, and the two is combined into three-dimensional network by electrostatic attraction, increases
The compactness of big film promotes heat-resisting beta-carotin microcapsule powder, light, oxygen, and embedding rate is high, and the physical chemistry for improving product is stablized
Property and shelf life.
3, the preparation process of beta-carotin microcapsule powder of the present invention does not use any organic solvent, and in production process not
Any waste is generated, environmentally protective production technology is belonged to.
Specific embodiment
Below with reference to embodiment, the present invention is described in more detail, but protection scope of the present invention is not limited only to these realities
Apply example.
Embodiment 1
1, oily phase is prepared
2g beta carotene crystal, 0.5g Rosmarinic acid, the mono- bi-tristearin of 1g are added to 20g sunflower oil
In, 60 DEG C of stirring 1h, obtain oily phase under nitrogen protection.
2, water phase is prepared
10g casein sodium, 1g dipotassium hydrogen phosphate are added in 100mL distilled water, in 60 DEG C of aquation 2h, obtain albumen
Content is the water phase of 0.1g/mL.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 500MPa.
4, two layers of lotion are prepared
4g pectin is added in 50mL distilled water, stirs 2h at 60 DEG C, it is water-soluble to obtain the pectin that concentration is 0.08g/mL
Liquid；Then the aqueous pectin solution is mixed with the initial latex of step 3,2h is stirred at room temperature, obtain two layers of lotion.
5, whole lotion is prepared
61.5g maltodextrin is dissolved in 50mL distilled water, obtains the maltodextrin aqueous solution that concentration is 1.23g/mL, so
The maltodextrin aqueous solution is mixed with two layers of lotion of step 4 afterwards, 1h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 160 DEG C of inlet temperature, 100 DEG C of outlet temperature, obtains slow-release beta carotene
Microcapsule powder.
Embodiment 2
1, oily phase is prepared
1g beta carotene crystal, 1g Rosmarinic acid, the mono- bi-tristearin of 0.5g are added to 10g sunflower oil
In, 160 DEG C of stirring 5min, obtain oily phase under nitrogen protection.
2, water phase is prepared
5g whey protein isolate, 0.5g dipotassium hydrogen phosphate are added in 100mL distilled water, in 60 DEG C of aquation 2h, obtained
Protein content is the water phase of 0.05g/mL.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 450MPa.
4, two layers of lotion are prepared
3g pectin is added in 50mL distilled water, stirs 2h at 60 DEG C, it is water-soluble to obtain the pectin that concentration is 0.06g/mL
Liquid；Then the aqueous pectin solution is mixed with the initial latex of step 3,2h is stirred at room temperature, obtain two layers of lotion.
5, whole lotion is prepared
79g maltodextrin is dissolved in 50mL distilled water, obtains the maltodextrin aqueous solution that concentration is 1.58g/mL, then
The maltodextrin aqueous solution is mixed with two layers of lotion of step 4,2h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 150 DEG C of inlet temperature, 90 DEG C of outlet temperature, obtains slow-release beta carotene
Microcapsule powder.
Embodiment 3
1, oily phase is prepared
By 5g beta carotene crystal, 0.3g Rosmarinic acid, 0.3g ascorbyl palmitate, the mono- double glycerol stearates of 1g
Ester is added in 30g sunflower oil, and 150 DEG C of stirring 10min, obtain oily phase under nitrogen protection.
2, water phase is prepared
10g beta lactoglobulin, 0.2g dipotassium hydrogen phosphate are added in 100mL distilled water, in 60 DEG C of aquation 4h, obtain egg
Bai Hanliang is the water phase of 0.1g/mL.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 400MPa.
4, two layers of lotion are prepared
5g pectin is added in 50mL distilled water, stirs 2h at 60 DEG C, it is water-soluble to obtain the pectin that concentration is 0.1g/mL
Liquid；Then the aqueous pectin solution is mixed with the initial latex of step 3,2h is stirred at room temperature, obtain two layers of lotion.
5, whole lotion is prepared
48.2g maltodextrin is dissolved in 50mL distilled water, the maltodextrin aqueous solution that concentration is 0.964g/mL is obtained,
Then the maltodextrin aqueous solution is mixed with two layers of lotion of step 4,1h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 160 DEG C of inlet temperature, 100 DEG C of outlet temperature, obtains slow-release beta carotene
Microcapsule powder.
Embodiment 4
1, oily phase is prepared
1g beta carotene crystal, 0.05g tea polyphenols, 0.5g diacetyl tartarate monoglyceride are added to 5g sunflower seeds
In oil, 160 DEG C of stirring 5min, obtain oily phase under nitrogen protection.
2, water phase is prepared
5g whey protein isolate, 0.5g dipotassium hydrogen phosphate are added in 100mL distilled water, in 60 DEG C of aquation 2h, obtained
Protein content is the water phase of 0.05g/mL.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 450MPa.
4, two layers of lotion are prepared
3g pectin is added in 50mL distilled water, stirs 2h at 60 DEG C, it is water-soluble to obtain the pectin that concentration is 0.06g/mL
Liquid；Then the aqueous pectin solution is mixed with the initial latex of step 3,2h is stirred at room temperature, obtain two layers of lotion.
5, whole lotion is prepared
84.95g maltodextrin is dissolved in 50mL distilled water, the maltodextrin aqueous solution that concentration is 1.699g/mL is obtained,
Then the maltodextrin aqueous solution is mixed with two layers of lotion of step 4,2h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 150 DEG C of inlet temperature, 90 DEG C of outlet temperature, obtains slow-release beta carotene
Microcapsule powder.
Embodiment 5
1, oily phase is prepared
1g beta carotene crystal, 0.1g Rosmarinic acid, 0.6g stearyl lactate are added in 5g sunflower oil,
The lower 160 DEG C of stirrings 5min of nitrogen protection, obtains oily phase.
2, water phase is prepared
5g whey protein isolate, 0.5g dipotassium hydrogen phosphate are added in 100mL distilled water, in 60 DEG C of aquation 2h, obtained
Protein content is the water phase of 0.05g/mL.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 450MPa.
4, two layers of lotion are prepared
3g pectin is added in 50mL distilled water, stirs 2h at 60 DEG C, it is water-soluble to obtain the pectin that concentration is 0.06g/mL
Liquid；Then the aqueous pectin solution is mixed with the initial latex of step 3,2h is stirred at room temperature, obtain two layers of lotion.
5, whole lotion is prepared
84.8g maltodextrin is dissolved in 50mL distilled water, the maltodextrin aqueous solution that concentration is 1.696g/mL is obtained,
Then the maltodextrin aqueous solution is mixed with two layers of lotion of step 4,2h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 150 DEG C of inlet temperature, 90 DEG C of outlet temperature, obtains slow-release beta carotene
Microcapsule powder.
Embodiment 6
1, oily phase is prepared
1g beta carotene crystal, 0.01g vitamin C, 0.005g vitamin E, 1g food-grade tween are added to 10g certain herbaceous plants with big flowers
In flower seed oil, 160 DEG C of stirring 5min, obtain oily phase under nitrogen protection.
2, water phase is prepared
5g whey protein isolate, 0.5g dipotassium hydrogen phosphate are added in 100mL distilled water, in 60 DEG C of aquation 2h, obtained
Protein content is the water phase of 0.05g/mL.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 450MPa.
4, two layers of lotion are prepared
3g pectin is added in 50mL distilled water, stirs 2h at 60 DEG C, it is water-soluble to obtain the pectin that concentration is 0.06g/mL
Liquid；Then the aqueous pectin solution is mixed with the initial latex of step 3,2h is stirred at room temperature, obtain two layers of lotion.
5, whole lotion is prepared
79.485g maltodextrin is dissolved in 50mL distilled water, the maltodextrin aqueous solution that concentration is 1.59g/mL is obtained,
Then the maltodextrin aqueous solution is mixed with two layers of lotion of step 4,2h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 150 DEG C of inlet temperature, 90 DEG C of outlet temperature, obtains slow-release beta carotene
Microcapsule powder.
Comparative example 1
1, oily phase is prepared
2g beta carotene crystal, 0.5g Rosmarinic acid, the mono- bi-tristearin of 1g are added to 20g sunflower oil
In, under nitrogen protection, 1h is stirred at 60 DEG C, obtains oily phase.
2, water phase is prepared
10g casein sodium is added in 100mL distilled water, in 60 DEG C of aquation 2h, obtaining protein content is 0.1g/mL
Water phase.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 500MPa.
4, two layers of lotion are prepared
4g pectin is added in 50mL distilled water, stirs 2h at 60 DEG C, it is water-soluble to obtain the pectin that concentration is 0.08g/mL
Liquid；Then the aqueous pectin solution is mixed with the initial latex of step 3,2h is stirred at room temperature, obtain two layers of lotion.
5, whole lotion is prepared
62.5g maltodextrin is dissolved in 50mL distilled water, obtains the maltodextrin aqueous solution that concentration is 1.25g/mL, so
The maltodextrin aqueous solution is mixed with two layers of lotion of step 4 afterwards, 1h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 160 DEG C of inlet temperature, 100 DEG C of outlet temperature, obtains beta-carotin microcapsule
Powder.
Comparative example 2
1, oily phase is prepared
2g beta carotene crystal, 0.5g Rosmarinic acid, the mono- bi-tristearin of 1g are added to 20g sunflower oil
In, 60 DEG C of stirring 1h, obtain oily phase under nitrogen protection.
2, water phase is prepared
10g casein sodium, 1g dipotassium hydrogen phosphate are added in 100mL distilled water, in 60 DEG C of aquation 2h, obtain albumen
Content is the water phase of 0.1g/mL.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 500MPa.
4, two layers of lotion are prepared
50mL distilled water is preheating to 60 DEG C, is then mixed with the initial latex with step 3,2h is stirred at room temperature, obtained
To two layers of lotion.
5, whole lotion is prepared
65.5g maltodextrin is dissolved in 50mL distilled water, obtains the maltodextrin aqueous solution that concentration is 1.31g/mL, so
The maltodextrin aqueous solution is mixed with two layers of lotion of step 4 afterwards, 1h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 160 DEG C of inlet temperature, 100 DEG C of outlet temperature, obtains beta-carotin microcapsule
Powder.
Comparative example 3
1, oily phase is prepared
2g beta carotene crystal, 0.5g Rosmarinic acid, 1g sucrose ester are added in 20g sunflower oil, protected in nitrogen
Lower 60 DEG C of stirrings 1h is protected, oily phase is obtained.
2, water phase is prepared
10g casein sodium, 1g dipotassium hydrogen phosphate are added in 100mL distilled water, in 60 DEG C of aquation 2h, obtain albumen
Content is the water phase of 0.1g/mL.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 500MPa.
4, two layers of lotion are prepared
4g pectin is added in 50mL distilled water, stirs 2h at 60 DEG C, it is water-soluble to obtain the pectin that concentration is 0.08g/mL
Liquid；Then the aqueous pectin solution is mixed with the initial latex of step 3,2h is stirred at room temperature, obtain two layers of lotion.
5, whole lotion is prepared
61.5g maltodextrin is dissolved in 50mL distilled water, obtains the maltodextrin aqueous solution that concentration is 1.23g/mL, so
The maltodextrin aqueous solution is mixed with two layers of lotion of step 4 afterwards, 1h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 160 DEG C of inlet temperature, 100 DEG C of outlet temperature, obtains beta-carotin microcapsule
Powder.
Comparative example 4
1, oily phase is prepared
2g beta carotene crystal, 0.5g Rosmarinic acid are added in 20g sunflower oil, stirred for 60 DEG C under nitrogen protection
1h is mixed, oily phase is obtained.
2, water phase is prepared
10g casein sodium is added in the imidazoles acetate buffer that 100mL pH is 2.4, in 60 DEG C of aquation 2h,
Obtain the water phase that protein content is 0.1g/mL.
3, initial latex is prepared
The oil of step 1 is mutually mixed with the water phase of step 2, the high speed shear 3min under 20 × 1000r/min revolving speed, then
Homogeneous 3 times, obtain initial latex at 500MPa.
4, two layers of lotion are prepared
4g pectin is added in the imidazoles acetate buffer that 50mL pH is 2.4, stirs 2h at 60 DEG C, obtain concentration
For the aqueous pectin solution of 0.08g/mL；Then the aqueous pectin solution is mixed with the initial latex of step 3, is stirred at room temperature
2h obtains two layers of lotion.
5, whole lotion is prepared
62.5g maltodextrin is dissolved in 50mL distilled water, obtains the maltodextrin aqueous solution that concentration is 1.25g/mL, so
The maltodextrin aqueous solution is mixed with two layers of lotion of step 4 afterwards, 1h is stirred at room temperature, obtains whole lotion.
6, it is spray-dried
Whole lotion is spray-dried, 160 DEG C of inlet temperature, 100 DEG C of outlet temperature, obtains beta-carotin microcapsule
Powder.
In order to prove beneficial effects of the present invention, β-Hu that inventor prepares above-described embodiment 1~6 and comparative example 1~4
Radish element microcapsule powder carried out embedding rate, the loss late of beta carotene, the shelf-life (by accelerated stability test, 40 DEG C,
75% relative humidity, vacuumizes lower test at no light), performance tests, the test result such as release rate be shown in Table 1.
Table 1
Seen from table 1, the beta-carotin microcapsule powder embedding rate that prepared by the embodiment of the present invention 1~6 is all larger than 98%；In room
Temperature, illumination, in exposure air under conditions of, 3 months loss lates are respectively less than 25%；Accelerated stability test (condition: 40 DEG C,
75% relative humidity, vacuumizes no light) to measure shelf life of products be 24 months；1h is in the release rate of simulated gastric fluid
15%~31%；3h is 17%~29% in the release rate of simulated intestinal fluid, reaches 98.4%~99.5% for 24 hours.With 1 phase of embodiment
Than comparative example 1 is not added with dipotassium hydrogen phosphate, and obtained product embedding rate reduces by 11.8%, and 3 months loss lates increase
19%, simulated intestinal fluid and gastric juice slow release effect are poor；Comparative example 2 is not added with pectin, and obtained product embedding rate reduces by 0.88%,
2 weeks loss lates are 56%, and simulated intestinal fluid and gastric juice slow release effect are worst, and the release rate of 3h simulated gastric fluid is that 78%, 3h is artificial
The release rate of intestinal juice is 63%；It is emulsifier that comparative example 3, which is added to sucrose ester, and obtained product embedding rate reduces by 11.22%, 2
The loss late in week is 38%, and simulated intestinal fluid and gastric juice slow release effect are poor, and the release rate of 3h simulated gastric fluid is the artificial intestines of 35%, 3h
The release rate of liquid is 76%；It is 2.4 that comparative example 4, which prepares water phase and the pH of two layers of lotion, and obtained product embedding rate reduces
6.92%, 2 weeks loss lates are 61%, and simulated intestinal fluid and gastric juice slow release effect are poor, and the release rate of 3h simulated gastric fluid is 35%,
The release rate of 3h simulated intestinal fluid is 53%.
Claims (8)
1. a kind of slow-release beta-carotin microcapsule powder, it is characterised in that the microcapsule powder by following percent mass proportionings raw material
It is made:
Above-mentioned antioxidant is Rosmarinic acid, vitamin E, vitamin A, ascorbyl palmitate, any one in tea polyphenols
Kind or two or more mixtures；
Above-mentioned emulsifier is spat for single bi-tristearin, diacetyl tartarate monoglyceride, stearyl lactate, food-grade
Middle benefit gas any one or two or more mixtures；
Above-mentioned albumen is whey protein isolate, casein sodium, beta lactoglobulin, any one in gelatin.
2. slow-release beta-carotin microcapsule powder according to claim 1, it is characterised in that the microcapsule powder is by following matter
The raw material of amount per distribution ratio is made:
3. slow-release beta-carotin microcapsule powder according to claim 1 or 2, it is characterised in that: the vegetable oil is
Miglyol 812, sunflower oil, any one in corn oil or two or more mixtures.
4. slow-release beta-carotin microcapsule powder according to claim 1 or 2, it is characterised in that: the emulsifier is
Single bi-tristearin.
5. slow-release beta-carotin microcapsule powder according to claim 1 or 2, it is characterised in that: the antioxidant
For the mixture of any one in Rosmarinic acid, vitamin E or both.
6. a kind of preparation method of slow-release beta-carotin microcapsule powder described in claim 1, it is characterised in that this method by
Following step composition:
(1) oily phase is prepared
Beta carotene crystal, antioxidant and emulsifier are added in vegetable oil, stirred under nitrogen protection complete to solid
Fully dissolved obtains oily phase；
(2) water phase is prepared
Albumen and dipotassium hydrogen phosphate are added in distilled water, in 50~70 DEG C of 2~12h of aquation, obtaining protein content is 0.01
The water phase of~0.5g/mL；
(3) initial latex is prepared
It is mutually mixed oily with water phase, high speed shear, then homogeneous 2~3 times at 300~500MPa obtain initial latex；
(4) two layers of lotion are prepared
Pectin is dissolved in distilled water, 2~4h is stirred at 50~70 DEG C, obtains the pectin water that concentration is 0.02~0.2g/mL
Then aqueous pectin solution is mixed with initial latex, 1~8h is stirred at room temperature by solution, obtain two layers of lotion；
(5) whole lotion is prepared
Maltodextrin is dissolved in distilled water, the maltodextrin aqueous solution that concentration is 0.2~3g/mL is obtained, then pastes malt
Smart aqueous solution is mixed with two layers of lotion, and 1~8h is stirred at room temperature, and obtains whole lotion；
(6) it is spray-dried
Whole lotion is spray-dried, 130~180 DEG C of inlet temperature, 90~120 DEG C of outlet temperature, obtains slow-release β-Hu
Radish element microcapsule powder.
7. the preparation method of slow-release beta-carotin microcapsule powder according to claim 6, it is characterised in that: step (1)
In, beta carotene crystal, antioxidant and emulsifier are added in vegetable oil, under nitrogen protection 50~200 DEG C of stirrings
It is completely dissolved to solid, obtains oily phase.
8. the preparation method of slow-release beta-carotin microcapsule powder according to claim 6, it is characterised in that: step (6)
In, whole lotion is spray-dried, 150~160 DEG C of inlet temperature, 100~110 DEG C of outlet temperature.
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| CN114868907A (en) * | 2022-05-30 | 2022-08-09 | 合肥工业大学 | Double-encapsulated β-carotene-based starch-based nanoparticles and their preparation and application |
| CN114868907B (en) * | 2022-05-30 | 2023-07-21 | 合肥工业大学 | Double-embedded β-carotene starch-based nanoparticles and its preparation and application |
| CN115868583A (en) * | 2022-10-09 | 2023-03-31 | 东北农业大学 | Composition for promoting intestinal development, feed additive, feed and preparation method and application thereof |
| CN116831263A (en) * | 2023-07-19 | 2023-10-03 | 上海统益生物科技有限公司 | Compound colorant β-carotene powder, preparation method and application |
| CN117243929A (en) * | 2023-10-17 | 2023-12-19 | 大连医诺生物股份有限公司 | Composition of carotenoid preparation and preparation method thereof |
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