CN101379964B - Hexythiazox suspending agent and preparation method thereof - Google Patents
Hexythiazox suspending agent and preparation method thereof Download PDFInfo
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- CN101379964B CN101379964B CN2008101325838A CN200810132583A CN101379964B CN 101379964 B CN101379964 B CN 101379964B CN 2008101325838 A CN2008101325838 A CN 2008101325838A CN 200810132583 A CN200810132583 A CN 200810132583A CN 101379964 B CN101379964 B CN 101379964B
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- Prior art keywords
- hexythiazox
- agent
- suspension
- dispersant
- sodium
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- XGWIJUOSCAQSSV-XHDPSFHLSA-N (S,S)-hexythiazox Chemical compound S([C@H]([C@@H]1C)C=2C=CC(Cl)=CC=2)C(=O)N1C(=O)NC1CCCCC1 XGWIJUOSCAQSSV-XHDPSFHLSA-N 0.000 title claims abstract description 42
- 239000005661 Hexythiazox Substances 0.000 title claims abstract description 42
- 239000000375 suspending agent Substances 0.000 title claims description 24
- 238000002360 preparation method Methods 0.000 title abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000002270 dispersing agent Substances 0.000 claims abstract description 11
- 239000003381 stabilizer Substances 0.000 claims abstract description 10
- 239000002562 thickening agent Substances 0.000 claims abstract description 10
- 230000002528 anti-freeze Effects 0.000 claims abstract description 3
- 239000000725 suspension Substances 0.000 claims abstract 5
- 239000013530 defoamer Substances 0.000 claims abstract 3
- 239000003795 chemical substances by application Substances 0.000 claims description 26
- -1 ester sodium salt Chemical class 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 8
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims description 6
- SZHOJFHSIKHZHA-UHFFFAOYSA-N tridecanoic acid Chemical compound CCCCCCCCCCCCC(O)=O SZHOJFHSIKHZHA-UHFFFAOYSA-N 0.000 claims description 6
- 229920002545 silicone oil Polymers 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 239000004283 Sodium sorbate Substances 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 claims description 3
- 235000019250 sodium sorbate Nutrition 0.000 claims description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 239000004633 polyglycolic acid Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229920005552 sodium lignosulfonate Polymers 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000428 dust Substances 0.000 abstract description 4
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 239000002917 insecticide Substances 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 238000003860 storage Methods 0.000 abstract description 2
- 238000002485 combustion reaction Methods 0.000 abstract 1
- 238000004880 explosion Methods 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 13
- 239000003814 drug Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 230000000740 bleeding effect Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241000488581 Panonychus citri Species 0.000 description 7
- 239000002518 antifoaming agent Substances 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 239000002689 soil Substances 0.000 description 6
- 241000207199 Citrus Species 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 238000000498 ball milling Methods 0.000 description 5
- 235000020971 citrus fruits Nutrition 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 238000011835 investigation Methods 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 239000004495 emulsifiable concentrate Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- 239000003905 agrochemical Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 235000011152 sodium sulphate Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000009736 wetting Methods 0.000 description 3
- 239000005663 Pyridaben Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical group [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000005416 organic matter Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000000361 pesticidal effect Effects 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- DWFZBUWUXWZWKD-UHFFFAOYSA-N pyridaben Chemical compound C1=CC(C(C)(C)C)=CC=C1CSC1=C(Cl)C(=O)N(C(C)(C)C)N=C1 DWFZBUWUXWZWKD-UHFFFAOYSA-N 0.000 description 2
- 235000021003 saturated fats Nutrition 0.000 description 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- YSUQLAYJZDEMOT-UHFFFAOYSA-N 2-(butoxymethyl)oxirane Chemical compound CCCCOCC1CO1 YSUQLAYJZDEMOT-UHFFFAOYSA-N 0.000 description 1
- CUFXMPWHOWYNSO-UHFFFAOYSA-N 2-[(4-methylphenoxy)methyl]oxirane Chemical compound C1=CC(C)=CC=C1OCC1OC1 CUFXMPWHOWYNSO-UHFFFAOYSA-N 0.000 description 1
- AOBIOSPNXBMOAT-UHFFFAOYSA-N 2-[2-(oxiran-2-ylmethoxy)ethoxymethyl]oxirane Chemical compound C1OC1COCCOCC1CO1 AOBIOSPNXBMOAT-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- RZXLPPRPEOUENN-UHFFFAOYSA-N Chlorfenson Chemical compound C1=CC(Cl)=CC=C1OS(=O)(=O)C1=CC=C(Cl)C=C1 RZXLPPRPEOUENN-UHFFFAOYSA-N 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 241000555678 Citrus unshiu Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- FQYUMYWMJTYZTK-UHFFFAOYSA-N Phenyl glycidyl ether Chemical compound C1OC1COC1=CC=CC=C1 FQYUMYWMJTYZTK-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241001454293 Tetranychus urticae Species 0.000 description 1
- 241001630065 Unaspis yanonensis Species 0.000 description 1
- ABUGVBRDFWGJRD-CHOYNLESSA-N [9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-methyloxolan-2-yl]-2-(2,4-dinitrophenyl)sulfanylpurin-6-yl] [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C2=NC(SC=3C(=CC(=CC=3)[N+]([O-])=O)[N+]([O-])=O)=NC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)=C2N=C1 ABUGVBRDFWGJRD-CHOYNLESSA-N 0.000 description 1
- JNVCSEDACVAATK-UHFFFAOYSA-L [Ca+2].[S-]SSS[S-] Chemical compound [Ca+2].[S-]SSS[S-] JNVCSEDACVAATK-UHFFFAOYSA-L 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 239000000642 acaricide Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 229920006184 cellulose methylcellulose Polymers 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- YAQXGBBDJYBXKL-UHFFFAOYSA-N iron(2+);1,10-phenanthroline;dicyanide Chemical compound [Fe+2].N#[C-].N#[C-].C1=CN=C2C3=NC=CC=C3C=CC2=C1.C1=CN=C2C3=NC=CC=C3C=CC2=C1 YAQXGBBDJYBXKL-UHFFFAOYSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000005405 multipole Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229940096992 potassium oleate Drugs 0.000 description 1
- MLICVSDCCDDWMD-KVVVOXFISA-M potassium;(z)-octadec-9-enoate Chemical compound [K+].CCCCCCCC\C=C/CCCCCCCC([O-])=O MLICVSDCCDDWMD-KVVVOXFISA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
本发明公开了一种噻螨酮悬浮剂，这种悬浮剂由以下重量百分比的组分组成：噻螨酮1％～50％，消泡剂0.1％～1％，分散剂0.5％～10％，防冻剂1％～10％，增稠剂0.1％～5％，稳定剂0.01％～20％，渗透剂0～10％，水10％～80％。本发明还公开了上述噻螨酮悬浮剂的制备方法。本发明的噻螨酮悬浮剂具有闪点高，不燃烧不爆炸，生产、储存、使用安全，粉尘少，环境污染小，产品成本低，容易包装，杀虫效果好等优点。The invention discloses a hexythiazox suspension, which is composed of the following components in weight percentage: 1% to 50% of hexythiazox, 0.1% to 1% of defoamer, 0.5% to 10% of dispersant, 1% to 10% of antifreeze, 0.1% to 5% of thickener, 0.01% to 20% of stabilizer, 0% to 10% of penetrant, and 10% to 80% of water. The invention also discloses a preparation method of the hexythiazox suspension. The hexythiazox suspension has the advantages of high flash point, no combustion and no explosion, safe production, storage and use, less dust, less environmental pollution, low product cost, easy packaging, good insecticide effect, etc.
Description
Technical field
The invention belongs to the agricultural chemicals preparation field, be specifically related to a kind of hexythiazox suspension agent and preparation method thereof.
Background technology
Hexythiazox, (hexythiazox), chemical name: (4RS, 5RS)-5-(4-chlorphenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazoles alkane-3 carboxylic acid amides.It is novel thiazolidine ketone miticide.The evil mite is had and tags by force and stomach poison function; The crop epidermis is had stronger osmosis, can infiltrate in the blade and be penetrated into the harmful mite that blade back kills blade back, but do not have systemic action; To the mite ovum, if mite and young mite are all effective; To becoming the mite virulence very little; Yet, touch incubation rate that the female one-tenth mite of medicament laid eggs and be at half very much behind the medicine and arrived drug effect peak, lasting period 40-50 days in 7-10 days; The effect of using when high temperature or low temperature does not have significant difference, at present domestic-developed Hexythiazox wetting powder and missible oil.
This year, the friendly insecticidal/acaricidal agent of national requirements exploitation, the acute exploitation of agricultural chemicals is to water baseization, ultramicronising, no dust and the development of sustained release aspect.Wherein water baseization is exactly one of main direction of agricultural chemicals development.Water can reduce the consumption of organic solvent as the suspending agent of solvent, does not have the dust pollution that wetting powder, pulvis bring and the smell of missible oil to pollute again, and has reduced the pesticide producing cost, has become the very important formulation in the pesticidal preparations.
Summary of the invention
The objective of the invention is Hexythiazox to be dispersed in the deionized water with small solid state, thereby a kind of suspending agent that can reduce the consumption of the organic solvent in the pesticidal preparations is provided by the effect of dispersant and the physics peptizaiton of ball mill.
Another object of the present invention provides a kind of preparation method of above-mentioned suspending agent
The object of the invention can reach through following measure:
A kind of hexythiazox suspension agent, form by following components in weight percentage:
Hexythiazox 1%～50% antifoaming agent 1%～15%
Dispersant 0.5%～50% antifreezing agent 0.1%～10%
Thickener 0.3%～10% stabilizing agent 0.01%～20%
Bleeding agent 0～10% water 10%～80%
Dispersant is selected from sodium lignin sulfonate, calcium lignosulfonate, lauryl alcohol polyethylene glycol oxide base ether sodium sulfate, alkyl naphthalene formaldehyde condensate sulfonates, neopelex, lauryl sodium sulfate, potassium oleate, enuatrol, alkyl polyoxyethylene ether sulfonate, alkylphenol-polyethenoxy base ether formaldehyde condensation products, alkylphenol-polyethenoxy base ether Nonyl pheno base ether, polyoxyethylene polyoxypropylene base ether block copolymers, draw back powder, gather in the second carboxylic esters sodium salt one or more.
Thickener is selected from one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate or the polyvinyl alcohol.
Stabilizing agent is selected from one or more in catechol, butyl glycidyl ether, phenyl glycidyl ether, cresyl glycidyl ether, polyethylene glycol diglycidyl ether, chloropropylene oxide, sodium sorbate, Sodium Benzoate, epoxidised soybean oil, linseed oil, quinhydrones, anthraquinone, citric acid, hydroxy benzoate or the propylparaben.
Antifoaming agent is selected from one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.Wherein silicone compound such as organosilicon etc., C10-20 saturated fat acid compounds such as hendecanoic acid, tridecanoic acid, pentadecanoic acid etc., C8-10 aliphatic alcohols compound such as certain herbaceous plants with big flowers alcohol, ten alkanols etc.
Antifreezing agent is selected from one or more in ethylene glycol, glycerine, propane diols, polyethylene glycol, the sorbierite.
Bleeding agent is organosilicon, azone, AEO etc.
A kind of method for preparing hexythiazox suspension agent; It is characterized in that Hexythiazox and dispersant, thickener, stabilizing agent, antifoaming agent, antifreezing agent, bleeding agent and water even by the described mixed of claim 1; With ball milling in the ball mill 2～3 hours, make particle diameter all below 5 μ m.
In the formulations of pesticide, conventional dosage forms is main with EC (emulsifiable concentrate), WP (wetting powder), and water baseization formulation came into the market successively in nearly 2 years, and suspending agent (SC) then is representative wherein.Having in it is matrix with water, and particle diameter is generally 1～35 μ m, average 90% particle diameter≤5 μ m, and suspensibility>=90%, high the opening up and tackness of performance on the crop blade face, it uses drug effect to compare with WP, and very big difference is arranged.
The present invention is scattered in the particle of Hexythiazox with miniaturization in the water, thereby has:
1) flash-point is high, and nonflammable difficult blast is safer to production, storage and user;
2) dust is few, and environmental pollution is little, to the producer and user and Environmental security;
3) with water be matrix, aboundresources, product cost is low, easily packing;
4) Hexythiazox is killed mite active ingredient and have protective effect;
5) after the said preparation spraying, be distributed in crop surface, so " instantaneous " concentration of insect's food-taking is high, good disinsection effect with fine particle;
6) preventive effect is better behind the adding bleeding agent.
Embodiment
Embodiment 1 5% hexythiazox suspension agent
Each constituent content (by weight) is the former powder 5g of Hexythiazox, dispersant sodium lignin sulfonate 10g, and thickener xanthans 2g, stabilizing agent catechol 2g, antifoaming agent silicone oil 1g, bleeding agent organosilicon 2g, antifreeze glycol 3g adds deionized water to 100g.Mix back ball milling 2～3 hours in ball mill, make particle diameter all below 5 μ m.
Embodiment 2 10% hexythiazox suspension agents
Each constituent content (by weight) is the former powder 10g of Hexythiazox, dispersant lauryl alcohol polyethylene glycol oxide base ether sodium sulfate 10g, thickener CMC 3g; Stabilizing agent butyl glycidyl 2.5g, antifoaming agent silicone oil 1g, bleeding agent organosilicon 2g; Antifreezing agent glycerine 3g adds deionized water to 100g.Mix back ball milling 2～3 hours in ball mill, make particle diameter all below 5 μ m.
Embodiment 3 15% hexythiazox suspension agents
Each constituent content (by weight) is the former powder 15g of Hexythiazox, dispersant lauryl alcohol polyethylene glycol oxide base ether sodium sulfate 8g, thickener CMC 3g; Stabilizing agent butyl glycidyl 2.5g, antifoaming agent silicone oil 1%, bleeding agent organosilicon 2g; Antifreezing agent glycerine 3g adds deionized water to 100g.Mix back ball milling 2～3 hours in ball mill, make particle diameter all below 5 μ m.
Embodiment 4 20% hexythiazox suspension agents
Each constituent content (by weight) is the former powder 20g of Hexythiazox, and dispersant gathers second carboxylic esters sodium salt 10g, thickener xanthans 2g, and stabilizing agent sodium sorbate 2g, antifoaming agent tridecanoic acid 2g, bleeding agent organosilicon 2g, antifreezing agent glycerine 3g adds deionized water to 100g.Mix back ball milling 2～3 hours in ball mill, make particle diameter all below 5 μ m.
5% hexythiazox suspension agent agent control citrus red mite field control effectiveness test
1, test objective
Exploration supplies best field using dosage, concentration and the spraying time of reagent agent 5% hexythiazox suspension agent control citrus red mite, and tentatively estimating test medicine influences trial crops, for the evaluating drug effect and the safety of agriculture chemical registration, reasonable operation technique provide foundation.2 experimental conditions
2, subjects, crop and breed selection
Citrus red mite (Panonychus citri).Citrus, kind are emerging Tianjin of series, Wenzhou kind.
Environmental condition: 13 mu of test tangerine garden areas, ground, north orientation sun gentle slope by east, kind is the Xing Jin of satsuma mandarin series, the age of tree 9 years; 1.5 * 3 meters of seeding row spacings, density 148 strain/mus, soil are yellow mud crust soil, the content of organic matter 1.54%; PH value 6.5, the poor ridge of fertility, irrigation conditions is relatively poor.Winter in 2006, mu was executed 100 kilograms of carbon ammoniums, 50 kilograms of general calcium, 500 kilograms of farmyard manures.
3, experimental scheme and arrangement
3.1 medicament
3.1.1 test medicine 5% hexythiazox suspension agent, autogamy.
3.1.2 contrast medicament
5% Hexythiazox missible oil; Kesheng Group Co., Ltd., Jiangsu Prov. produces.Commercial
15% pyridaben missible oil; The Hubei sand swell reaches limited company and produces.Commercial
3.1.3 dosing and numbering
Table 1 supplies reagent agent experimental scheme
| Handle numbering | Medicament | Dispenser dosage (amount of formulation) | Formulation rate (active ingredient amount mg/kg) |
| 1 | 5% Hexythiazox SC | ?3000 | 166.7 |
| 2 | 5% Hexythiazox SC | 3500 | 142.8 |
| 3 | 5% Hexythiazox SC | 4000 | 125.0 |
| 4 | 5% Hexythiazox EC | 2000 | 125.0 |
| 5 | 15% pyridaben EC | 2000 | 75.0 |
| 6 | The CK clear water | / | / |
3.2.2 sub-district area and repetition
Sub-district area: two fruit trees in every sub-district.
Number of repetition: 4 times.
3.3 application method
3.3.1 the method for using hand spray squirts whole blade desires with soup and does not drip degree of being.
3.3.2 spraying equipment.
Singapore produces Jacto board HD-400 type knapsack hand sprayer, operating pressure 8Kgf/cm2, injection diameter 1.33mm.
3.3.3 a spraying time and a number of times dispenser on June 24.
3.3.4 the capacity of use administration of medical fluid amount is 2220 liters/hectare (citrus density 148 strain/mus).
3.3.5 prevent and treat the medicament data of other damage by disease and insect
On December 12nd, 2006 was killed the citrus germ that survives the winter with 28 times of liquid of 20% lime sulfur;
4, investigation, record and measuring method
4.1 meteorology and soil information
4.1.1 meteorological data is fine June 24,26.3 ℃ of mean temperature of air, relative air humidity 70%.
4.1.2 soil information
Soil is yellow mud crust soil, the content of organic matter 1.54%, and pH value 6.5, fertility is barren, and irrigation conditions is relatively poor.
4.2 investigation method, time and number of times
4.2.1 control time and number of times
Investigation radix (June 24) before the dispenser is done investigation in 1 day, 3 days, 10 days, 15 days, 20 days, 30 days behind the medicine respectively on June 25, June 27, July 4, July 9, July 14, July 24.
4.2.2 investigation method
Every sub-district 2 strains tree, east, south, west, north, the tender tip of middle five positions mark of every strain tree are investigated 25 movable mite quantity on the blade altogether.
4.2.3 drug effect computational methods
4.3 direct influence to crop
Supply each processing of reagent agent 5% hexythiazox suspension agent that citrus is not had the poisoning phenomenon.
4.4 the quality of product and output
Supply reagent agent 5% hexythiazox suspension agent can improve the output of product.
4.5 other biological is influenced
4.5.1 influence to other damage by disease and insect
Supply reagent agent 5% hexythiazox suspension agent that the citrus arrowhead scales is had certain inhibitory action.
4.5.2 influence to other non-target organisms
Supply reagent agent 55% hexythiazox suspension agent that the nothing of other non-target organism is obviously influenced.
5, result and analysis
Table 2 5% hexythiazox suspension agent control citrus red mite field control effectiveness test result
Adopt the new multipole of Deng Kenshi poor (DMRT) method to carry out statistical analysis, utilize the DPS analysis software to analyze.
Supply reagent agent 5% hexythiazox suspension agent that citrus red mite is had the better prevention effect, its 3000 times of liquid are handled and the preventive effect and the two contrast chemicals treatment of 3500 times of liquid processing relatively have clear superiority.
Recommending using dosage is 166.7～142.8 (ai) mg/kg, and dispenser when two spotted spider mite is taken place in a large number should be noted during use being used alternatingly with other insecticide, to prevent drug-fast generation.
Table 3-1 5% hexythiazox suspension agent control citrus red mite field control effectiveness test result's statistics (2007)
Table 3-2
Table 4 dispenser same day is weather conditions table (2007) experimental field
| The dispenser date | Weather conditions | Wind direction and wind-force | Temperature (℃) | Relative moisture (%) | Other climatic factors |
| June 24 | Fine | Gentle breeze | 26.3 | 70 |
Table 5 duration of test meteorological data table (2007)
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| CN101642099B (en) * | 2009-08-31 | 2012-10-17 | 桂林集琦生化有限公司 | Pesticide suspension concentrate with organosilicon surfactant and preparation method thereof |
| CN102293214A (en) * | 2011-09-27 | 2011-12-28 | 江苏省绿盾植保农药实验有限公司 | Acaricide composition containing hexythiazox and amitraz |
| CN104920423A (en) * | 2015-06-12 | 2015-09-23 | 福建省德盛生物工程有限责任公司 | Low-volume spray with hexythiazox |
| CN111406754B (en) * | 2020-04-28 | 2021-06-15 | 浙江禾本科技股份有限公司 | Hexythiazox water suspending agent and preparation method thereof |
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