CN101317949A - Method for preparing capsule for nourishing blood, regulating menstruation and nourishing blood and liver - Google Patents
Method for preparing capsule for nourishing blood, regulating menstruation and nourishing blood and liver Download PDFInfo
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- CN101317949A CN101317949A CNA2008101406106A CN200810140610A CN101317949A CN 101317949 A CN101317949 A CN 101317949A CN A2008101406106 A CNA2008101406106 A CN A2008101406106A CN 200810140610 A CN200810140610 A CN 200810140610A CN 101317949 A CN101317949 A CN 101317949A
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- Prior art keywords
- nourishing blood
- radix
- liver
- capsule
- regulating menstruation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008280 blood Substances 0.000 title claims abstract description 38
- 210000004369 blood Anatomy 0.000 title claims abstract description 38
- 239000002775 capsule Substances 0.000 title claims abstract description 21
- 230000005906 menstruation Effects 0.000 title claims abstract description 20
- 210000004185 liver Anatomy 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title claims abstract description 10
- 230000001105 regulatory effect Effects 0.000 title claims description 18
- 239000000843 powder Substances 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 5
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 3
- -1 filter Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 8
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 239000002552 dosage form Substances 0.000 abstract description 2
- 238000001035 drying Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 244000189799 Asimina triloba Species 0.000 abstract 1
- 235000006264 Asimina triloba Nutrition 0.000 abstract 1
- 235000009467 Carica papaya Nutrition 0.000 abstract 1
- 241000510667 Conioselinum Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 240000002948 Ophiopogon intermedius Species 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 abstract 1
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
- 238000007670 refining Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 239000000047 product Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 208000019838 Blood disease Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000244155 Taenia Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 239000008361 herbal raw material Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a method for producing a capsule for enriching blood, normalizing menstruation and nourishing the liver. The present invention includes the following procedures: refining eight medicinal materials of prepared radix rehmanniae, angelica, white peony, hemlock parsley, spine date seed, pawpaw, dwarf lilyturf and baked liquorice; preparing the medicinal materials into dry powder and proportionally mixing the dry powder with stearic acid magnesium; taking ethanol as the moisturizing agent and preparing mixture into particles; drying and capsulizing. The present invention has the characteristics of simple and clear composition, advanced technique, easy quality control, high technological content, convenient use for patients, good taste, difficult moist absorption and good stability; the capsule is characterized by high biological utilization and equal curative effect with other dosage forms. The preparation with reasonable design, convenient use and convenient carry has the unique curative effect of enriching blood, normalizing menstruation and nourishing the liver.
Description
Technical field
The present invention relates to a kind of medicine of capsule for nourishing blood, regulating menstruation and nourishing blood and liver.Especially a kind of Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba etc. eight flavor Chinese crude drugs are made into the manufacture method that capsule is used for nourishing blood, regulating menstruation and nourishing blood and liver.
Background technology
Treating at present nourishing blood, regulating menstruation and nourishing blood and liver disease Chinese patent medicine commonly used clinically has a lot, and they differ from one another, and goodish effect is all arranged; But the medicine of controlling nourishing blood, regulating menstruation and nourishing blood and liver is still based on Western medicine, and the Western medicine effect is often too single again.Someone once designed Chinese crude drugs such as Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae was made into tablet, and adjuvant is soluble starch, Pulvis Talci, magnesium stearate, but this product stability is poor, and the moisture absorption is rotten easily, and additive is many in the tablet, and active substance content is lower, and dose is big.
Summary of the invention
The objective of the invention is to Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Semen Ziziphi Spinosae, Fructus Chaenomelis, Radix Ophiopogonis, Radix Glycyrrhizae Preparata eight flavor Chinese crude drugs are made into a kind of capsule after extracting effective ingredient, this capsule can overcome the deficiency that existing product exists, and for nourishing blood, regulating menstruation and nourishing blood and liver unique curative effect is arranged.
The present invention is achieved in that
The selected herbal raw material of the present invention is eight, and it is made up of the proportioning of following parts by weight: 0.3 part in Radix Rehmanniae Preparata, 0.35 part of Radix Angelicae Sinensis, 0.3 part of the Radix Paeoniae Alba, 0.2 part of Rhizoma Chuanxiong, 10 parts of Semen Ziziphi Spinosaes, 20 parts of Fructus Chaenomeliss, 0.5 part of Radix Ophiopogonis, 0.2 part of Radix Glycyrrhizae Preparata.The manufacture method of capsule for nourishing blood, regulating menstruation and nourishing blood and liver: Os Draconis, Concha Ostreae, give birth to Radix Paeoniae Alba, Radix Cynanchi Atrati, Radix Ophiopogonis, Radix Cyathulae, the Radix Rehmanniae, Radix Scrophulariae, Fructus Gardeniae, Caulis Bambusae In Taenia, blue or green Folium Citri tangerinae, Fructus Aurantii (parched), the Radix Glycyrrhizae pulverize separately becomes fine powder, cross 100 mesh sieves, decocting boils secondary, the decocting that adds for the first time 8 times boiled 1.5 hours, the decocting that adds for the second time 8 times of amounts boiled 1.5 hours, merging filtrate, filter, filtrate is concentrated into the clear paste that relative density is 1.10 (70 ℃), spray drying, make dried cream powder, with above-mentioned fine powder mixing, must do medicated powder, calculate: get dried medicated powder with composition by weight, magnesium stearate is made wet granular with the ethanol of simmer down to 70%～90% as wetting agent in 1: 0.05～0.1 ratio mixing.Drying is made dried granule, and is encapsulated, promptly.
Capsule for nourishing blood, regulating menstruation and nourishing blood and liver of the present invention is that it constitutes simple, clear and definite, quality and is easy to control with Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Semen Ziziphi Spinosae, Fructus Chaenomelis, Radix Ophiopogonis, the Radix Glycyrrhizae Preparata eight flavor Chinese crude drugs medicine that to be raw material make by advanced person's preparation method, the capsule of making is the Sugarless type preparation, can increase the crowd of being suitable for, capsule is Chinese medicine advanced person's a dosage form, with high content of technology, patient's taking convenience, mouthfeel is good, be difficult for the moisture absorption, good stability; It is few that this product and tablet have been compared dose, and curative effect has the characteristics of equivalence with it.This capsule has definite curative effect to nourishing blood, regulating menstruation and nourishing blood and liver, especially nourishing blood, regulating menstruation and nourishing blood and liver is had unique curative effect.Its volume is little, and is easy to carry, the standing medication that is fit to family and travels away from home.
Embodiment 1
Calculate with composition by weight: get dried medicated powder 500g, magnesium stearate 50g mixing in 1: 0.1 ratio, edible ethanol 6ml with simmer down to 90% makes wet granular as wetting agent, dry about 70 ℃, make capsule, be up to the standards, powdery promptly gets and is applicable to the capsule for nourishing blood, regulating menstruation and nourishing blood and liver finished product.
The specific embodiment:
Radix Rehmanniae Preparata 0.3g, Radix Angelicae Sinensis 0.35g, Radix Paeoniae Alba 0.3g, Rhizoma Chuanxiong 0.2g, Semen Ziziphi Spinosae 10g, Fructus Chaenomelis 20g, Radix Ophiopogonis 0.5g, Radix Glycyrrhizae Preparata 0.2g.Be ground into fine powder, cross 100 mesh sieves.Amount to the 1720g medical material, decoct with water secondary, the decocting that adds 13.76kg for the first time boiled 1.5 hours, and the decocting that adds 13.76kg for the second time boiled 1.5 hours, merging filtrate, filter, filtrate is concentrated into the clear paste that relative density is 1.10 (70 ℃), spray drying, baking temperature is about 120 ℃, make dried cream powder,, must do medicated powder with above-mentioned fine powder mixing.Two components calculate in one: take by weighing dried medicated powder 500g, magnesium stearate 25g mixing in 1: 0.05 ratio, edible ethanol 4ml with simmer down to 70% makes wet granular as wetting agent, dry about 50 ℃, make capsule, be up to the standards, powdery promptly gets and is applicable to the capsule for nourishing blood, regulating menstruation and nourishing blood and liver finished product.
The function of this product cures mainly: nourishing blood, regulating menstruation and nourishing blood and liver.
Claims (4)
1, a kind of manufacture method of capsule for nourishing blood, regulating menstruation and nourishing blood and liver is characterized in that it is to have the raw material of following parts by weight to make; 0.3 part in Radix Rehmanniae Preparata, 0.35 part of Radix Angelicae Sinensis, 0.3 part of the Radix Paeoniae Alba, 0.2 part of Rhizoma Chuanxiong, 10 parts of Semen Ziziphi Spinosaes, 20 parts of Fructus Chaenomeliss, 0.5 part of Radix Ophiopogonis, 0.2 part of Radix Glycyrrhizae Preparata.
2, a kind of manufacture method of capsule for nourishing blood, regulating menstruation and nourishing blood and liver.It is characterized in that; Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Semen Ziziphi Spinosae, Fructus Chaenomelis, Radix Ophiopogonis, Radix Glycyrrhizae Preparata pulverize separately become fine powder, cross 100 mesh sieves; Decoct with water the secondary merging filtrate, filter, filtrate is concentrated into the clear paste that relative density is 1.10 (70 ℃), and spray drying is made dried cream powder, with above-mentioned fine powder mixing, must do medicated powder; Calculate with composition by weight: get dried medicated powder, make wet granular as wetting agent with the ethanol of simmer down to 70%～90%, dry, make dried granule, encapsulated, promptly.
3, the manufacture method of a kind of capsule for nourishing blood, regulating menstruation and nourishing blood and liver according to claim 2 is characterized in that: the temperature of spray drying chamber is 100 ℃～120 ℃.
4, the manufacture method of a kind of capsule for nourishing blood, regulating menstruation and nourishing blood and liver according to claim 2 is characterized in that; The baking temperature temperature is 50 ℃～70 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101406106A CN101317949A (en) | 2008-07-15 | 2008-07-15 | Method for preparing capsule for nourishing blood, regulating menstruation and nourishing blood and liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101406106A CN101317949A (en) | 2008-07-15 | 2008-07-15 | Method for preparing capsule for nourishing blood, regulating menstruation and nourishing blood and liver |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101317949A true CN101317949A (en) | 2008-12-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101406106A Pending CN101317949A (en) | 2008-07-15 | 2008-07-15 | Method for preparing capsule for nourishing blood, regulating menstruation and nourishing blood and liver |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101317949A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614371A (en) * | 2012-04-08 | 2012-08-01 | 申志恩 | Drug for treatment of female impotence and production method thereof |
| CN103025326A (en) * | 2010-06-30 | 2013-04-03 | 爱思开生物制药株式会社 | Methods of treating restless legs syndrome |
-
2008
- 2008-07-15 CN CNA2008101406106A patent/CN101317949A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103025326A (en) * | 2010-06-30 | 2013-04-03 | 爱思开生物制药株式会社 | Methods of treating restless legs syndrome |
| CN103025326B (en) * | 2010-06-30 | 2015-07-29 | 爱思开生物制药株式会社 | The method for the treatment of restless legs syndrome |
| CN102614371A (en) * | 2012-04-08 | 2012-08-01 | 申志恩 | Drug for treatment of female impotence and production method thereof |
| CN102614371B (en) * | 2012-04-08 | 2013-09-04 | 申志恩 | Drug for treatment of female impotence and production method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20081210 |