CN101228876B - Mixed Pesticide Preparation of Rotenone and Pyrimiden - Google Patents

Abstract

The invention discloses a pesticide preparation with rotenone and fluacrypyrim as the main raw materials, which is mixed prepared by 0.05 to 70 percent of rotenone, 1 to 70 percent of fluacrypyrim and a promoter of the left percentage. The invention makes use of the synergism action of rotenone and fluacrypyrim to realize the aims of overcoming the insecticide resistance of evil mites, enlarging the using range of the medicament and prolonging the effect period, which can greatly reduce the poisoning effect to various natural enemies and is favorable for reducing the pesticide effect to the ecological environment.

Description

Mixed Pesticide Preparation of Rotenone and Pyrimiden

technical field

The invention belongs to the technical field of pesticides. In particular, it relates to a pesticide preparation mixed with rotenone and pyrimaben.

Background technique

At present, chemical acaricides are mostly used in the prevention and control of agricultural pest mites, which can easily lead to the development of resistance of pest mites, and at the same time kill a large number of beneficial natural enemies, resulting in rampant damage of pest mites, polluting the environment, and easily causing human and animal poisoning. Therefore, the development of environmentally friendly acaricides is an urgent need for agricultural production.

Rotenone is a compound derived from the root of plant Rotenone and the leaves of edamame. It has excellent acaricidal activity, degrades quickly in the environment, and does not harm natural enemies and other non-target organisms. Its disadvantage is that it is unstable and has fewer processed dosage forms.

Fluacrypyrim, the first methoxyacrylate acaricide, is highly effective against resistant pest mites currently in agriculture.

The research on the mixing of the above two insecticides is expected to obtain a rotenone mixed acaricide that can overcome the resistance of pest mites, expand the control spectrum, reduce the dosage, delay the duration of the drug, and have various dosage forms.

Contents of the invention

The purpose of the present invention is to fill up the gap in the prior art and provide an efficient and safe rotenone-pyrimiden acaricide compounded acaricide. Through the reasonable mixing of rotenone and pyrimidaben, the control spectrum is expanded, the efficacy of the drug is improved, the dosage of the drug is reduced, and the pollution to the environment is reduced.

The technical solution of the present invention is to provide a pesticide preparation mixed with rotenone and pyrimaben, which is prepared by mixing 0.05-70% by weight of rotenone, 1-70% by weight of pyrimidate and the balance of auxiliary agents.

As a preferred solution of the present invention, the mixed pesticide preparation is prepared by mixing 0.5-50% by weight of rotenone, 2-55% by weight of pyrimidin and the balance of auxiliary agents.

The rotenone can be one or more of the original medicine, the plant extract containing rotenone or the rotenone preparation, and when using multiple kinds, the total usage amount cannot be greater than the maximum value of the portion.

The pyrimidone can be the original drug and/or preparation, and when using multiple kinds, the total usage amount cannot be greater than the maximum value of the part.

The beneficial effects of the present invention are:

1. After mixing rotenone and pyrimidaben, it can not only overcome the shortcoming of pyrimidaben that is easy to produce resistance, but also maintain the advantages of the mixture as a biological pesticide, and can broaden the application range of the pesticide, extend the duration of efficacy, and improve the efficacy of the drug , plays an important role in the control of pest mite resistance.

2. After mixing rotenone and pyrimaben, the dosage of the mixture is reduced, and the production cost is reduced under the premise of improving the efficacy.

3. Due to the reasonable compatibility and ratio of the various substances required for the preparation of this type of acaricide, it can greatly reduce the toxic effect on various natural enemies, and is conducive to reducing the impact on the ecological environment.

Detailed ways

The technical content of the invention will be further described in detail below in conjunction with specific embodiments, but the content of the present invention is not limited thereto.

Embodiment 1: the preparation of 2.5% rotenone+pyrimiden emulsifiable concentrate, the weight ratio of each component is:

Rotenone is 0.05%;

Pyrimiden is 2.45%;

Surfactant: dodecylphenol polyoxyethylene ether is 15%;

Co-solvent: methanol is 15%;

Anti-photolysis agent: castor oil is 1%;

Stabilizer: epoxidized soybean oil is 17%;

Penetrant: Laurocaprazine is 12%;

Organic solvent: make up to 100% xylene.

Put each component into the preparation kettle and mix thoroughly to obtain the product.

Embodiment 2: the preparation of 3% rotenone+pyrimiden emulsifiable concentrate, the weight ratio of each component is:

Rotenone is 2%;

Pyrimiden is 1%;

Surfactant: dodecylphenol polyoxyethylene ether is 15%;

Co-solvent: methanol is 15%;

Anti-photolysis agent: castor oil is 1%;

Stabilizer: epoxidized soybean oil is 17%;

Penetrant: Laurocaprazine is 12%;

Organic solvent: make up to 100% xylene.

Put each component into the preparation kettle and mix thoroughly to obtain the product.

Embodiment 3: the preparation of 3% rotenone+pyrimiden emulsifiable concentrate, the weight ratio of each component is:

Rotenone is 0.3%;

Pyrimiden is 2.7%;

Surfactant: dodecylphenol polyoxyethylene ether is 15%;

Co-solvent: methanol is 15%;

Anti-photolysis agent: castor oil is 1%;

Stabilizer: epoxidized soybean oil is 17%;

Penetrant: Laurocaprazine is 12%;

Organic solvent: make up to 100% xylene.

Put each component into the preparation kettle and mix thoroughly to obtain the product.

Embodiment 4: the preparation of 75% rotenone+pyrimiden wettable powder, the weight ratio of each component is:

Rotenone is 70%;

Pyrimiden is 5%;

Wetting agent: sodium lauryl sulfate is 5%;

Dispersant: 10% of alkyl sulfonate;

Carrier: kaolin supplemented to 100%;

The components are dried, cooled, mixed and ground to obtain the product.

Embodiment 5: the preparation of 75% rotenone+pyrimiden wettable powder, the weight ratio of each component is:

Rotenone is 5%;

Pyrimiden is 70%;

Wetting agent: sodium lauryl sulfate is 5%;

Dispersant: 10% of alkyl sulfonate;

Carrier: Kaolin supplemented to 100%.

The components are dried, cooled, mixed and ground to obtain the product.

Embodiment 6: the preparation of 10% rotenone+pyrimiden wettable powder, the weight ratio of each component is:

Rotenone is 0.5%;

Pyrimiden is 9.5%;

Wetting agent: sodium lauryl sulfate is 25%;

Dispersant: 22% of alkyl sulfonate;

Carrier: Kaolin supplemented to 100%.

The components are dried, cooled, mixed and ground to obtain the product.

Embodiment 7: the preparation of 30% rotenone+pyrimidin oil suspension concentrate, the weight ratio of each component is:

Rotenone is 10%;

Pyrimiden is 20%;

Dispersant: sodium lignosulfonate is 10%;

Viscosifier: bentonite is 3%;

Stabilizer: xanthan gum is 2%;

Defoamer: organic silicone is 5%;

Solvent: castor oil to 100%.

Put each component into a sand mill and grind it, then put it into a homogeneous mixer and mix it evenly to get the product.

Embodiment 8: the preparation of 15% rotenone+pyrimiden microemulsion, the weight ratio of each component is:

Rotenone is 5%;

Pyrimiden is 10%;

Emulsifier: calcium salt of alkylbenzenesulfonate is 20%;

Stabilizer: cresyl glycidyl ether is 13%;

Solvent: butanone is 20%;

Antifreeze: 8% sorbitol;

Make up to 100% with deionized water.

Stir the mixture in a stirrer, heat and invert the phase to obtain the product.

Embodiment 9: the preparation of 60% rotenone+pyrimidin water-dispersible granules, the weight ratio of each component is:

Rotenone is 10%;

Pyrimiden is 50%;

Wetting agent: sodium lignosulfonate is 5%;

Binder: 5% polyvinyl acetate;

Disintegrant: 10% urea;

Carrier: Activated white clay supplemented to 100%;

Example 10: Preparation of 40% rotenone+pyrimidin water-dispersible granules, the weight ratio of each component is:

Rotenone is 20%;

Pyrimiden is 20%;

Wetting agent: sodium lignosulfonate is 8%;

Binder: 9% polyvinyl acetate;

Disintegrant: urea is 15%;

Carrier: Activated white clay supplemented to 100%;

Example 11: Preparation of 40% rotenone+pyrimidin water-dispersible granules, the weight ratio of each component is:

Rotenone is 10%;

Pyrimiden is 30%;

Wetting agent: sodium lignosulfonate is 8%;

Binder: 9% polyvinyl acetate;

Disintegrant: urea is 15%;

Carrier: Activated white clay supplemented to 100%;

The mixture is ultrafinely pulverized, then granulated, dried and sieved to obtain the product.

Example 12: The preparation of 30% rotenone+pyrimidin microcapsules, the weight ratio of each component is:

Rotenone is 9%;

Pyrimiden is 21%;

Dispersant: 10% polyvinyl alcohol;

Capsule wall material: gelatin supplemented to 100%.

The components are mixed and stirred at high speed for 2 hours, the polymer is separated by salting out, heated to form microcapsules, and then freeze-dried to obtain the product.

The mixed pesticide preparations prepared in the above examples are shown in Table 1 according to the comparison results of conventional laboratory toxicity tests and single-dose pesticides.

Table 1 Indoor toxicity test results of various mixed agents against citrus spider mite

Pharmacy Dilution factor Mortality 2.5% Rotenone EC 1000 52.2% 30% pyrimaben gel suspension 5000 76.4% 0.05% Rotenone + 2.45% Pyrimiden EC 2000 78.1% 2% Rotenone + 1% Pyrimiden EC 2000 79.3% 0.3% rotenone + 2.7% pyrimaben EC 2000 88.2% 70% rotenone + 5% pyrimaben wettable powder 10000 100% 5% rotenone + 70% pyrimaben wettable powder 10000 100%

0.5% rotenone + 9.5% pyrimaben wettable powder 5000 85.8% 10% rotenone + 20% pyrimaben oil suspension concentrate 8000 92.5% 5% rotenone + 10% pyrimaben microemulsion 5000 91.4% 10% rotenone + 50% pyrimaben water dispersible granules 10000 100% 20% rotenone + 20% pyrimaben water dispersible granules 8000 100% 10% rotenone + 30% pyrimaben water dispersible granules 8000 100% 9% rotenone + 21% pyrimaben microcapsules 6000 100%

Screening experiment of synergistic effect of mixture of rotenone and pyrimaben: Single agent and mixed agent were prepared into different concentration liquids to treat citrus red spider mite, and clear water was used as control. Calculate the LC50 and co-toxicity coefficient of the drug. For example, if the co-toxicity coefficient is close to 100, it indicates an additive effect, if it is greater than 100, it indicates a synergistic effect, and if it is less than 100, it indicates an antagonistic effect. The test results are shown in Table 2.

Table 2 Results of synergistic screening test on citrus spider mite mixed with rotenone and pyrimidin

Pharmacy ratio LC₅₀(μg/ml) 95% Confidence Limits Co-toxicity coefficient Rotenone 5.22 3.50-7.79 0 pyrimifen 0.20 0.14-0.29 0 Rotenone: Pyrimiden (1:100) 0.16 0.11-0.22 131.38 Rotenone: Pyrimiden (1:50) 0.12 0.08-0.18 176.56 Rotenone: Pyrimiden (100:1) 4.00 2.86-5.58 105.05 Rotenone: Pyrimiden (50:1) 2.20 1.49-3.25 160.15 Rotenone: Pyrimiden (1:1) 0.22 0.16-0.31 176.64 Rotenone: Pyrimiden (1:4) 0.21 0.15-0.29 120.23 Rotenone: Pyrimidin (1:10) 0.18 0.11-0.28 127.17 Rotenone: Pyrimiden (1:30) 0.17 0.11-0.27 121.49

It can be seen from Table 2 that the co-toxicity coefficient of the mixture of rotenone and pyrimaben is greater than 100, which indicates that the reasonable mixture of rotenone and pyrimaben has a synergistic effect.

Example 13 Experiment on the effect of the mixed pesticide preparation of rotenone and pyrimidin:

Experiment 1: After diluting 3% rotenone and pyrimaben EC, 2.5% rotenone EC and 30% pyrimaben gel suspension respectively 1500 times, 500 times, and 2000 times, the citrus Panonychus was sprayed, and then after the treatment Investigate and calculate the control effect on the 1st, 3rd, 7th, and 14th day.

1500 times of 3% rotenone·pyrimidin EC against Panonychus citrus on the 1st, 3rd, 7th, and 14th days after treatment were 80.9%, 89.3%, 98.9%, 95.8% respectively; 500 times of 2.5% rotenone EC The control effects against Panonychus citrus on the 1st, 3rd, 7th, and 14th days were 25.7%, 35.4%, 76.3%, and 81.2% respectively; The control effects on the 1st, 3rd, 7th, and 14th day after administration were 83.4%, 90.5%, 93.2%, and 71.8%, respectively.

Experiment 2: After diluting 15% rotenone and pyrimaben microemulsion, 2.5% rotenone emulsifiable concentrate and 30% pyrimaben gel suspension respectively 4,000 times, 500 times, and 2,000 times, the cotton spider mite was treated by spraying. 1, 3, 7, 14 days to investigate and calculate the control effect.

4000 times of 15% rotenone and pyrimaben microemulsions were 81.3%, 90.2%, 99.1%, and 93.6% respectively on the 1st, 3rd, 7th, and 14th day after medication of cotton spider mites; 500 times of 2.5% rotenone EC The 1st, 3rd, 7th, and 14th days after the cotton red spider medication, the control effects were 45.1%, 55.2%, 68.3%, and 83.2% respectively; The control effects of 3, 7, and 14 days were 75.4%, 90.2%, 94.6%, and 81.5%, respectively.

Compared with the original pesticides, the compounded pesticides of the present invention have significant control effect and long lasting effect on the control of pests from the above efficacy tests.

Claims (2)

1. A mixed pesticide preparation of rotenone and pyrimidin, characterized in that it is formed by mixing 0.5-50% by weight of rotenone, 2-55% by weight of pyrimidin and the balance of auxiliary agents. 2. according to claim 1 described rotenone and pyrimidin mixed pesticide preparation, it is characterized in that being mixed by each component of following percentage by weight: Rotenone 20%; Pyrimiden 20%; Wetting agent sodium lignosulfonate 8%; Binder polyvinyl acetate 9%; Disintegrant urea 15%; Carrier activated clay The balance.