CN101184518A - Radiopharmaceutical pigs and portable powered injectors - Google Patents
Radiopharmaceutical pigs and portable powered injectors Download PDFInfo
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- CN101184518A CN101184518A CNA2006800170542A CN200680017054A CN101184518A CN 101184518 A CN101184518 A CN 101184518A CN A2006800170542 A CNA2006800170542 A CN A2006800170542A CN 200680017054 A CN200680017054 A CN 200680017054A CN 101184518 A CN101184518 A CN 101184518A
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Abstract
Certain embodiments of the invention relate to a radiopharmaceutical system having a shielded cordless injector and various radiopharmaceutical pig and syringe structures that permit the syringe to remain in the pig during transportation and use of the syringe. In some embodiments, the shielded cordless injector may include an injector, a radiation shield disposed at least partially about the injector, a drive coupled to the injector, and an energy storage device coupled to the drive. The pig may have a computer with a display screen that displays a radioactivity level of a radiopharmaceutical and/or a desired (e.g., correct) unit dose volume of a radiopharmaceutical to be administered to a patient.
Description
The application related to and requirement, submitted serial number No.60/681,330, the U.S. Provisional Patent Application of RADIOPHARMACEUTICAL PIG by name on May 16th, 2005; Submit serial number No.60/681,254, the U.S. Provisional Patent Application of RADIOPHARMACEUTICALSYRINGE AND PIG COMBINATION by name on May 16th, 2005; Submit serial number No.60/681,253, the priority of the U.S. Provisional Patent Application of RADIOPHARMACEUTICALFILLING AND DELIVERY SYSTEM by name on May 16th, 2005.
Technical field
A kind of electronic medical fluid infusion device of relate generally to of the present invention, and more specifically, relate to a kind of power injector and/or energy storing device that has such as the radiation shield characteristic.
Background technology
The purpose of this part be will be relevant with the various aspects of the present invention of following introduction and/or requirement various technology introductions give the reader.Believe that thereby this introduction helps to be convenient to understand better various aspects of the present invention for the reader provides background information.Therefore, should be understood that these statements will read by this angle, rather than for the approval of prior art.
Provide treatment technology person to run into on-the-spot problem of filling needle tubing with radiopharmaceutical usually.Correctly using radiation shield by the technician during syringe absorption and calibration process is a series of challenge.The radial spine tube shield is often heavier and use trouble and can hinder during with radiopharmaceutical suction syringe and observe for the technician.Under certain conditions, the use of syringe radiation shield can hinder radiopharmaceutic processing and increase and be used for drawing and dosage calibration process institute's time spent.
Power injector is often used in the armarium of patient infusion liquid.For example, during some processing and diagnostic procedure, utilize power injector to the patient infusion medicine.Similarly, power injector can be to patient infusion contrast agent or labelled reagent.Usually, power injector comprises the electro-motor of needle tubing and driven syringe.Generally speaking, electro-motor attracts power by power line.Unfortunately, power line can hinder moving of power injector, makes potentially that thus power injector is not easy to use more.
Summary of the invention
To be illustrated in below on the scope and the corresponding particular aspects of claim of the present invention.Should be understood that these aspects only are to propose for the simple and clear summary that the particular form that can adopt the present invention is provided to the reader, and these aspects are not intended to and limit the scope of the invention.In fact, the present invention can comprise the many aspects of not introducing below.
A first aspect of the present invention relates to a kind of radiopharmaceutical pigs, and it is convenient to extract from container the radiopharmaceutical of expectation (for example, correct) unit dose volume.Radiopharmaceutical pigs electrically demonstration is contained in the radiopharmaceutic real-time radioactive level in the container in the jar.Therefore, if there is identical radiopharmaceutic several vessels, the clinician can determine that by the simple display of observing on the jar which container also should at first use at most apace.
Some radiopharmaceutical pigs of the present invention can be determined exact unit's dose volume simply by the clinician, reduces the requirement of the clinician being inquired about chart, electrical form and the program that uses a computer thus.The expectation prescribed dose of some radiopharmaceutical pigs of the present invention response clinician input electrically calculates and shows correct unit dose volume.Special characteristic of the present invention is to help especially to extract radiopharmaceutical from container in needle tubing by hand.
A second aspect of the present invention can provide a kind of radiopharmaceutical needle tubing and jar combination, and it has reduced the people potentially for from radiopharmaceutic radiating exposure (for example, during radiopharmaceutical injection is in the patient).The radiopharmaceutical needle tubing of this aspect and a jar combination can protect potentially the people one of in electronic and manual injection radiopharmaceutical or both the time avoid radiation.Thus, radiopharmaceutical needle tubing of some this aspect and jar combination can be particularly useful for during slow long injection of radioactive substances process and providing radiating protection at least.
In the third aspect, the present invention is devoted to a kind of equipment that is used for fixing with injection of radioactive substances.This equipment comprises jar, cover and syringe.Jar has main body, and it comprises the radiation shielding material (for example, lead, tungsten, tungstenic plastics etc.) that one or more are fit to.This main body of jar generally has the socket that is defined in wherein, thereby holds at least a portion of syringe.In addition, this main body generally includes the exit opening that is limited to the one end.Thereby the cover design of this equipment for connection releasedly and main body can cover the user as required or unlimited main body one end on exit opening.This equipment is designed to support needle tubing in main body.As a result, needle tubing is retained in the main body of equipment at injection of radioactive substances (from syringe) during the patient.
For fourth aspect, the present invention can provide a kind of multiple dose radiopharmaceutical to fill and induction system, and it allows needle tubing to go up at the scene by disposal person and effectively fills (for example, with enough little cost and/or enough little radioactive exposure risk).To a certain extent, filling of the present invention and induction system are tended to be reduced in and are filled needle tubing and injection of radioactive substances one of in the patient time or both radioactive exposure risks.One of in when to a certain extent, filling of the present invention and induction system can reduce electronic and manual injection radiopharmaceutical or both radioactive exposure risks.Therefore, some embodiment of filling of the present invention and induction system can be particularly useful for during slow long injection of radioactive substances process provides radiating protection.
Aspect the 5th, the present invention is devoted to a kind of being used for and fills the equipment of needle tubing from holding radiopharmaceutic medicine bottle.This equipment generally include have pedestal, medicated cap and the container that is suitable for holding the radiation shield of radiopharmaceutic medicine bottle except pedestal split shed zone base closed.This equipment also comprises fills and injection device, and it comprises main body and mounting structure.The opening that the main body of filling and injection device generally includes sidewall and extends by sidewall.The mounting structure of filling and injection device is suitable for supporting syringe usually, and the syringe needle of syringe is arranged in the opening of main body.Container and filling and injection device are typically designed to and make the sidewall of main body to make the opening in the pedestal to locate near the opening in the main body by storage container.This is arranged so that the radiopharmaceutical in the medicine bottle can be communicated with needle tubing syringe needle fluid.At least from an angle, of the present invention being characterised in that in this respect is used for radiopharmaceutic power injector and shielding harness, the radioactive exposure during it has promoted accurate filling and has reduced filling and injection process.
For the 6th aspect, the present invention relates to a kind of being used for to shift the equipment of radiopharmaceutical to syringe from having the membranous medicine bottle of being convenient to radiopharmaceutical is sealed in wherein.This equipment comprises filling and injection device and container.Container be typically designed to by orientation fixedly medicine bottle make the opening of container be close to the barrier film of medicine bottle.The radiation shield of container is typically designed to be substantially disposed in and holds radiopharmaceutic medicine bottle except around the diaphragm area.The filling of this equipment and injection device comprise main body and are suitable for supporting the mounting structure of syringe that the syringe needle of syringe is arranged in body openings.Fill and the body design of injection device is acceptance (or holding) part of container at least, its mode makes opening in the apparatus main body near the opening of container.In addition, container and device preferably are arranged so that the needle pierces barrier film of needle tubing, make that thus the radiopharmaceutical in the medicine bottle is communicated with syringe fluid.
Aspect the 7th, the present invention is devoted to a kind of equipment, is used for filling needle tubing from holding radiopharmaceutic medicine bottle.This equipment comprises container, and it is suitable for fixedly holding radiopharmaceutic medicine bottle and it comprises radiation shield.In addition, this equipment comprises fills and injection device, and it comprises the mounting structure that is suitable for supporting needle tubing, and the syringe needle of needle tubing is arranged in the opening of apparatus main body.Apparatus main body is designed to be arranged on around at least a portion of medicine bottle, and is suitable for making the radiopharmaceutical in the medicine bottle to be communicated with the syringe needle fluid of needle tubing usually.The electromechanical device of this equipment can be suitable for bias voltage (for example, push away forward and/or regain) thereby the push rod of needle tubing utilizes the radiopharmaceutical in the medicine bottle to fill needle tubing.
A eighth aspect of the present invention is devoted to a kind of from having the method that the membranous medicine bottle of contained radioactivity medicine medicine bottle filled needle tubing.In the method, provide the container of radiation shield with sealing medicine bottle major part.Thereby this container almost fixed medicine bottle at least makes the barrier film adjacent vessel opening of medicine bottle.Needle tubing can be arranged in filling and the injection device, thereby makes the needle tubing syringe needle be arranged in the opening of filling and injection device.Container can be positioned at the top of filling and injection device, fills and injection device opening top thereby the medicine bottle barrier film is positioned at.In container and filling and the injection device at least one can move relative to each other, thereby thereby makes the barrier film of the needle pierces medicine bottle of needle tubing make the radiopharmaceutical in the medicine bottle be communicated with the needle tubing fluid.
A ninth aspect of the present invention is devoted to a kind of shielding, and the cordless injector assembly comprises syringe, the radiation shield that is provided with at least in part, the energy storing device that is coupled to the driver of needle tubing and is coupled to driver around syringe.
A tenth aspect of the present invention is devoted to a kind of powered injector systems, has needle tubing, is coupled to the actuated syringes device of needle tubing and the electric capacity that is coupled to the actuated syringes device.
A eleventh aspect of the present invention is devoted to a kind of method, and wherein power storage and shields the radiopharmaceutical of environment from cordless injector in cordless injector.In addition, the mobile electric energy that utilizes of active material drives.
Existence is to the various improvement of the top feature that proposes about various aspects of the present invention.Further feature also can be introduced these various aspects.These improve and extra feature can independence or the existence of combination in any.For example, below can be alone about each features of the one or more introductions in the illustrated embodiment or combination in any ground introduce the aspect of any one the invention described above.In addition, top brief overview only is intended to be convenient to the reader and is familiar with particular aspects of the present invention and content, and the claim main body is not construed as limiting.
Description of drawings
To make when below the reference accompanying drawing is read, introducing in detail these and other feature of the present invention, aspect and advantage obtain better to understand, Reference numeral identical in the accompanying drawing is represented identical parts in the accompanying drawings all the time, wherein:
Fig. 1 illustrates the sketch map of an embodiment that is used for holding at the life period of improvement jar the improvement jar of radiopharmaceutic container;
Fig. 2 is the perspective view of improvement jar shown in Figure 1;
Fig. 3 is the schematic block diagram of the circuit that adopts in the improvement jar shown in Figure 1;
Fig. 4 illustrates the sketch map that is used at another embodiment of the improvement jar that holds radiopharmaceutic container and control, the more accurate device of dosage;
Fig. 4 A is the sketch map of improvement jar end view drawing shown in Figure 4;
Fig. 5 illustrates the sketch map that uses needle tubing and jar combination;
Fig. 6 A to 6C is the perspective view of an embodiment of needle tubing and jar combination;
Fig. 7 A is the schematic section of another needle tubing and jar combination;
Fig. 7 B is the needle tubing of Fig. 6 A and the perspective view of jar combination;
Fig. 7 C is the schematic section of another needle tubing and jar combination;
Fig. 8 is the sketch map that the exemplary embodiments of filling of multiple dose radiopharmaceutical and induction system is shown;
Fig. 9 is medicine bottle and is installed in and the filling that the multiple dose radiopharmaceutical is filled and induction system is together used of Fig. 8 and the sectional view of the bottle container on the injection device;
Figure 10 is and the filling that the multiple dose radiopharmaceutical is filled and induction system is together used of Fig. 8 and the anterior elevational view of injection device;
Figure 11 is installed in and the filling that the multiple dose radiopharmaceutical is filled and induction system is together used of Fig. 8 and the perspective view of the bottle container on the injection device;
Figure 12 for the schematic block diagram of the control system of the multiple dose radiopharmaceutical of Fig. 8 is filled and induction system is together used filling and injection device;
Figure 13 is the schematic block diagram of the exemplary embodiments of wireless filling and injection device;
Figure 14 is the schematic block diagram of the exemplary embodiments of battery powered filling and injection device;
Figure 15 is the schematic block diagram of the exemplary embodiments of capacitances to supply power filling and injection device;
Figure 16 is the diagram of the exemplary embodiments of wireless filling and injection device and base;
Figure 17 is the diagram with exemplary embodiments of the wireless filling of crosspointer pipe and injection device;
Figure 18 is the diagram with exemplary embodiments of the wireless filling of typical syringe and injection device;
Figure 19 is the flow chart that the exemplary embodiments of using the one or more nuclear medicine procedure in Fig. 1 to 18 illustrated embodiment is shown;
Figure 20 is the block diagram that the exemplary embodiments of using the one or more radiopharmaceutical production system in Fig. 1 to 18 illustrated embodiment is shown; And
Figure 21 is the block diagram that the exemplary embodiments of using the one or more nuclear imaging system in Fig. 1 to 18 illustrated embodiment is shown.
The specific embodiment
To introduce one or more specific embodiment of the present invention below.For the succinct introduction to these embodiment is provided, can in description, all not be introduced the used unit in the practical application.Should understand, in the exploitation of any this practical application, as in any engineering and design, thereby must make decision to multiple concrete application and realize developer's objectives, such as the relevant and commercial relevant constraint of the system that submits to, and these can be different for a kind of application and another kind of application.In addition, it should be understood that this development effort can be complexity and consuming time, but to those skilled in the art,, but be the normal work to do of design, processing and making by help of the present disclosure.
A typical life cycle of radiopharmaceutical container and associated tank is shown radiopharmaceutical biosystem 18 in Fig. 1.With reference to Fig. 1, container 20 can be filled and encapsulation in supply factory 24, and it can be with wherein radiopharmaceutic facility to be used 42 is far away or near.In supply factory 24, container 20 can filled station 28 filling radiopharmaceutical.Radiopharmaceutic quality control checking can be at the quality control station 31 be carried out; Thereafter, container 20 can be placed in the jar 33.The jar 33 of powder charge can encapsulate and transportation/receiving department 38 can temporarily be arranged and be stored in to canister 34 separately or as a collection of in the canister that is fit at canning station 36 subsequently.
Order to radiopharmaceutical container 20 can receive from various sources, for example, the purchasing office 25 of medical facilities 42, perhaps as facility 42 parts or with its doctor's office 27 independently.In addition, order can or the patient with specific is not relevant.Based on order, canister 34 can enter the channel of distribution 40, can be transported to facility 42 by it, for example hospital or other medical facilities.In the example of Fig. 1, facility 42 is a hospital, and it has the transportation/receiving area 44 that is used to receive the canister 34 that holds the jar 33 that is filled with radiopharmaceutic container 20.Usually (but not always), canister 34 are stored in the nuclear medicine portion 29 in the hospital 42, and it generally includes radiopharmaceutical chamber 48 and/or office treatment 26.As required, container 20 can take out from jar 33; In the more accurate process 49 of dosage, radiopharmaceutical can be drawn into from container 20 in the needle tubing 69, prepares to be expelled among the patient 52.
The radiopharmaceutical that extracts exact unit's dose volume in needle tubing 69 need be known radiopharmaceutic plan radioactive level when disposing usually.For making judgement, radioactive level, filling time and the date when knowing such as the filling needle tubing usually, the information that time and date and radiopharmaceutic radioactive decay speed are disposed in plan are very helpful.Use the gentle radiopharmaceutic prescribed dose of plan radioactive water when disposing, then can determine exact unit's dose volume.Thus, as previously mentioned, for the clinician who has given current available instrument, determining of exact unit's dose volume is very difficult and consuming time.
In described embodiment, fill the cleaning of station 28, quality control checking station 31, container disposal and jar and finish in supply factory 24 away from hospital 42.In optional embodiment, one or more can the finishing other position inside and outside radiopharmaceutical chamber or hospital in these processes.
Fig. 2 shows radiopharmaceutical pigs 33, determines radiopharmaceutic exact unit dosage easily thereby it can be used by the clinician.Be used for fixing the jar 33 that holds radiopharmaceutic container and have main body 101 and lid 103, it is fixed in main body according to well-known way (for example, bayonet type connects).Main body 101 and lid 103 can present any suitable jar design, shape and structure, and shown in being not limited to.In other words, principle of the present invention can be applied to comprise one or more radiation shielding materials and be used for fixing the needle tubing known or any radiopharmaceutical pigs of medicine bottle.
With reference to Fig. 1, in supply factory 24, part as the preparation of radiopharmaceutical prescription, jar computer processor 113 can utilize data programing, for example, one or more of time and date, radiopharmaceutic prescribed dose etc. are disposed in radiopharmaceutic identification and rate of decay, radiopharmaceutic time and date, patient's name, the plan that records radioactive level, measurement.Data can be stored in the memorizer 114, and can be through can being that the communication link 117 of wired or wireless link is input in the digital processing unit 113.In addition, data manually or automatically one or many (for example, between the warming up period of radiopharmaceutical prescription) be input in jar computer processor 113.
Known the gentle radioactive decay speed of radioactive water when filling, a jar computer processor 113 is designed to automatic renewal (for example, substantially in real time) jar 33 interior radiopharmaceutic radioactive levels.In some embodiment of jar 33, inner radiopharmaceutical radioactive level at that time can (for example, mCi/mL) will represent that the numerical value of radioactive level at that time is presented on first character display 119 in the display screen 107 according to the unit that is fit to.Thus, during storage or transfer cask 33, jar computer processor 113 can continuously change the numerical value of display 119 expressions, thereby reflects radiopharmaceutic radioactive level in the container 20 substantially in real time.The jar computer processor 113 of some embodiment can also show the numerical value of the radiopharmaceutical prescribed dose that (in second character display 121 in display screen 107) expression is stored.Known the gentle prescribed dose of real-time radioactive water, the digital processing unit 113 of those embodiment just can show (in the 3rd character display 123 in display screen 107) expression radiopharmaceutical exact unit dose volume numerical value (for example, by clinician's suction syringe or from being prefilled within syringe the jar penetrates).
Just before injection of radioactive substances in patient 52, the clinician can observe second character display 121 of the radiopharmaceutical prescribed dose that expression early enrolls.If the prescribed dose of this prescribed dose and clinician expectation mates, then the clinician can read the 3rd character display 123 simply and determines radiopharmaceutic exact unit dose volume.If prescribed dose since the requirement of prescription change, thereby the clinician can operate the numerical value that switch 109 and/or time switch 111 change second character display 121, thereby be complementary with new prescribed dose.
Can also wish to change prescribed dose because the time and date of disposing with the change of when assigning prescription, being planned to some extent.In this case, radiopharmaceutic prescribed dose (for example, volume injected) can be just calculates based on radiopharmaceutic radioactive level at that time before disposal.In the radiopharmaceutical chamber 48 of hospital 42, the new value of radiopharmaceutical radioactive level and rate of decay and/or prescribed dose can be through switch 109,111 or communication link 117 manually or automatically, for example use the computer in the truing tool, be input in jar computer processor 113.
After the use, container 20 can be placed in the jar 33 once more, and turns back to supply factory 24.At post processing station 51, radiopharmaceutical container 20 can be disposed, and jars 33 can clean and re-use (for example, in the known manner).
With reference to Fig. 4, it shows the jar of the microprocessor that comprises the input/output device with certain type.Jar 33a is designed to fix, stores and/or transports and holds radiopharmaceutic medicine bottle; Jar 33b is designed to fix, stores and/or transports and holds radiopharmaceutic needle tubing.Jar 33a and 33b have corresponding main body 101a and 101b and corresponding lid 103a and 103b, and it can be pulled down in known manner from the main body 101a and the 101b of correspondence, in order to carry out the loading and unloading of radiopharmaceutical medicine bottle or needle tubing.
Yet, in the embodiment of Fig. 3 and 4, dose calibrator 296, control unit 292, base unit 291, jar processor 113 and input/output unit 284a, 284b, 286a, 286b have formed a system, and it can provide greater amount or the more accurate information relevant with radiopharmaceutic dosage for processor, technician or caregiver.In this example, jar computer processor 113 transmissions that control unit 292 can be in being arranged on medicine bottle 33a or syringe 33b and radiopharmaceutical, isotope type, be placed in medicine bottle or the needle tubing relevant data such as at that time radioactive activity level, patient's name.In addition, jar computer processor 113 prescription time that can calculate and will be stored among medicine bottle 33a or the syringe 33b offers corresponding output device 284a, 284b.Other data also can determine and show, for example, real-time activity level at that time, recommend consumption etc. at that time.Input equipment 282a, 282b can be used to give for change the data and the input new data of storage, and display screen 107 can be used to clinician's video data.For example, simultaneously in depressed state a period of time, jar computer processor 113 can the follow procedure output that radiopharmaceutical is discerned in display screen 107 provides the expression container by maintained switch 109,111.In other was used, switch 109,111 can be used for providing different Show Options by known way.For example, thereby display screen 107 can be closed energy savings by follow procedure over time, and display screen 107 can be by starting in depressed state a period of time one of in the maintained switch 109,111.Can increase other switch provides other Show Options, for example, restarts the operation that switch 125 can be used for digital processing unit 113 and resets.
Utilize each embodiment that introduces herein, the people of process tank 33a, 33b has obtained the up-to-date information relevant with radiopharmaceutical, with and age and activity level and need not open jar and physics touch medicine bottle or jar.Thus, reduced the processor to radiopharmaceutic potential exposure.In addition, often will keep the catalogue of various radioactivity medicines, output device 284a, 284b allow the processor to determine to select usually the earliest jar 33a, the 33b of use easily.
In the embodiment of Fig. 4, jar 33a, a 33b are electrically connected at base unit 291 by electric connector 288,289.In the first optional embodiment, base unit 291 and electric connector 289 can functionally be integrated in the control unit 292.For example, electric connector 289 can be installed on the control unit 292 by machinery, and/or is integrated into wherein.Thus, lead-in wire 293 will be in control unit 292, perhaps then can cancel if adapter 289 is directly installed on printed circuit board (PCB) in the control unit 292 or other substrate.In other embodiments, electric connector 288 can be installed on the end face of the sub-103a of cover, 103b.In another embodiment, can be installed in corresponding jar of end face 286a together with adapter 288 one of among I/O device 286a, the 286b, 286b is last or the end face of corresponding lid 103a, 103b on.In another embodiment, can use wireless connections, for example, by using rfid device (" RF-ID ").The RF-ID system is loaded with data in being commonly referred to tag transponder, these data are fetched by machine readable means.Thus, have for example the RF-ID label or the responder of chip, relational storage and at least one communication antenna of programmable processor, can be connected in a jar 33a, 33b.The information that data in RF-ID chip and the relational storage can provide various forms of and radiopharmaceutical and relevant medicine bottle or needle tubing to be correlated with jar.
The RF-ID system also requires to read data and will write the device of data to label in some applications from label, and is used for the device with computer or information management system communication data.Thus, data by machine readable means the when and where that is fit to from the RF-ID label read or if can be then to wherein writing, thereby satisfy specific application need.This machine readable means can be associated with base unit 291, perhaps can be associated with control unit 292, and in this embodiment, base unit 291 can be removed.Thus, the RF-ID system has the motility that allows data to write and read from label at different time and diverse location.
The typical life cycle of radiopharmaceutical needle tubing and jar combination 130 is shown in Figure 5.A radiopharmaceutical needle tubing and a jar combination 130 comprise needle tubing 132, are surrounded by jar 134 at least substantially.Radiopharmaceutical can be drawn in the needle tubing 132 and encapsulation in supply factory 24, supply factory 24 can with wherein to use radiopharmaceutic be provided with 42 far away or near.In supply factory 24, needle tubing 132 can extract station 28 fillings with radiopharmaceutical.During this filled, jar 134 can or can not be placed on around the needle tubing 132.Radiopharmaceutic quality control inspection can be at the quality control station 31 carries out.Thereafter, thereby port of export lid or sealing cap 140 and band can be additional to needle tubing and jar combination 130 along end cap 152 and provide and can effectively be characterized as a product that covers needle tubing and jar combination 131 fully, as shown in Figure 6A, it can provide radiopharmaceutic radiation shield in needle tubing.The needle tubing of block and jar combination 131 are subsequently can be at canning station 36 single or as a collection of encapsulation that is fit in the canister 34, transportation/receiving department 38 can temporarily be arranged or be stored in to canister 34.According to introducing similar mode with reference Fig. 1, based on instruction, canister 34 can enter and distribute passage 40, they can be transported to facility 42 and offer nuclear medicine portion 29 subsequently by it, and it can comprise radiopharmaceutical chamber 48 and/or office treatment 26.
With reference to Fig. 6 B, radiopharmaceutical needle tubing and jar combination 130 are made of needle tubing 132 and jar 134.Can body 136 is installed in syringe barrel or main body 138 all or on the major part, and can be completely or partially can be exposed to from radiopharmaceutic radiating any other material in the needle tubing 132 by plumbous, tungsten and/or protection people and constitute.The parts that can body 136 and cannula body 138 can be fabricated to a single body component or separate.Can body 136 can utilize binding agent, mechanical connection to be permanently fixed to cannula body 138, perhaps can simply slide on the cannula body 138 by interference engagement.Also can suitably adopt the alternate manner that jar is set around injecting body.
With reference to Fig. 6 B, a jar outlet end cap 140 can be used for covering connector 144 on the needle tubing port of export 142.The size and dimension of adapter 144 can be defined as to hold pipe.Jar outlet end cap 140 can be through interference engagement, be threaded, fastener or other provide the port of export 142 that the known way that wherein suppresses or eliminate the connection 153 (Fig. 6 A) of radiation leakage substantially was installed on and/or was contacted with cannula body 138 or can body 136 1 ends 145 in one of or both.The radiopharmaceutic radiating material that jar outlet end cap 140 can be avoided being exposed to from the needle tubing 132 by lead, tungsten and/or any other protection people whole or in part form.
The jar and the combinations of syringe 131 (Fig. 6 A) of capping can be used for craft or utilize the power injector injection of radioactive substances fully.For the manual injection shown in Fig. 6 B, provide the not jar of capping and needle tubing combination 135 fully thereby can take off jar end cap 140 and 152.Pipe (or other delivery conduit that is fit to) can be connected in adapter 144.Thereby the clinician subsequently can plunger depressed 146 injection of radioactive substances.In order together to use, can only take off end cap 140 with power injector; And, shown in Fig. 6 C, thereby can connect needle tubing and jar combination 133 that provides part to cover along end cap 152 by leave strip.Band can be designed as along end cap 152 and allows a needle tubing and a jar combination 130 to be installed in the power injector 158.By name " Injector " and transfer shown in assignee of the present invention's the U.S. Patent Application Publication No.US2004/0024361 A1 and introduce to know clearly and go for and the syringe and jar 133 typical power injectors that use of part capping.The full text of U.S. Patent Application Publication No.US 2004/0024361 A1 is herein incorporated by reference.
Manual or when together using with power injector, the people that the existence of the radiation shield that is provided along end cap (if use) by can body 136, plunger layer 150 (if use) and band can suppress to carry out the radiopharmaceutical administration at least substantially is exposed to radiation.After radiopharmaceutical penetrated from needle tubing 132, end cap 140 can be connected as shown in Figure 6A with 152, and the needle tubing of capping fully can return supply factory 24 with a jar combination 131.At post processing station 51, can handle needle tubing and jars 134 and end cap 140,152 can clean and re-use.
With reference to Fig. 7 A, another embodiment 130a of syringe jar combination comprises the needle tubing 160 that is installed in the jar 162.Jar 162 has the outer housing 164 and the liner 166 of lead, tungsten and/or other radiation shielding material.In this embodiment, syringe is for having the two-stage injec device of first and second plungers 163,165 respectively.Needle tubing 160 has with first chamber 167 of first port of export 184 with second chamber 169 of second port of export 186.Most advanced and sophisticated 188 removably are installed in the port of export 184,186 tops.First chamber 167 can be filled with radiopharmaceutical, and second chamber 169 can be filled with saline solution and/or other bio-compatible fluid that is fit to (for example, heparin solution, sterilization water, glucose solution etc.).Needle tubing 160 can be fixed on by the device that is fit in the jar 162 (for example, by recoverable clip 170, it is partial to the outer surface of needle tubing 160).Clip can unclamp by the release-push 172 that startup is installed on jar 162 outer surfaces 174.
Shown in Fig. 7 B, jar 162 can have printed label 173.In addition, jars 162 can have rfid device (" RF-ID ") 175, and it can be the part of label 173 or independent with it.The data relevant with radiopharmaceutical, needle tubing 160 and jars 162 can read and/or to wherein writing from RF-ID in each stage of the corresponding life cycle of those parts.In addition, jars 162 can have and comprise the display screen 179 that is installed on the outer surface 174 and/or such as the user interface 177 of the input equipment 181 of switch.Display screen 179 and/or switch 181 can be connected in the digital processing unit (not shown) with memorizer, and it can be used to store and radiopharmaceutical, data that its radioactive water equality is relevant.
The continued presence of the radiation shield that is provided by jar 162 and plunger layer 171 (if use) during the patient infusion radiopharmaceutical can suppress radioactive exposure at least substantially in the people who handles needle tubing and jar combination 130a and carry out the radiopharmaceutical administration.
In the optional embodiment shown in Fig. 7 C, needle tubing 160 can be fixed in the jar 162 by annular (or other is fit to design) outstanding 168, and it provides the interference engagement of jar 162 inner needle tubes 160.In another embodiment, according to radiopharmaceutic radiation level, can cancel the radiation shield protection of plunger.In addition, according to radiopharmaceutic radiation level, band can be made by the material that the anti-radiation protection shielding is not provided along end cap 152.
Each parts of radiopharmaceutical filling of typical case's multiple dose and induction system 200 are shown in Figure 8.This fills and induction system 200 can be suitable for locating to use disposal person.Filling and induction system 200 generally include shielding radiopharmaceutical container 206 and filling and injection device 220.Subsidiary saying, the radiation shield of container 206 can be any suitable shielding material (for example, lead, tungstenic plastics and/or tungsten).As described below, syringe is placed on fill and injection device 220 in after, radiopharmaceutical container 206 can be installed in as shown in figure 11 fills and injection device 220 pushes up.Thereby the power filling that provides with the radiopharmaceutical needle tubing of prescription dosage unit volume can be provided subsequently for filling and injection device 220.The power filling process of some embodiment is characterised in that fast, accurately and/or show the exposure lower than known system.Thereafter, container 206 can be thrown off from installing 220, thereby and filling and injection device 220 can operate and provide to patient's power injection of radioactive substances.Perhaps, thus needle tubing can from fill and injection device 220 takes off and manual use to the patient infusion radiopharmaceutical.
Disposal person buys the radiopharmaceutical multiple dose medicine bottle 202 (Fig. 8) from the radiopharmaceutical chamber, medicine bottle 202 can take out and be placed in the medicine bottle holder 204 of container 206 from its shipment jar.Medicine bottle holder 204 can be fixed in container base 210, and container cap 208 can be fixed on container base 210 tops.As shown in Figure 9, screw thread plug 216 can be installed in the medicated cap 208, and thus, medicated cap 208 can stably be fixed in pedestal 216 by the female thread on screw-threaded engagement screw thread plug 216 and the holder 204.Mechanical connection between medicated cap 208 and the pedestal 210 can be any suitable interconnecting, such as fast rotational screw thread (for example, steep-pitch thread, snap-type screw thread etc.).Any suitable radiation shielding material (for example, lead, tungstenic plastics and/or tungsten) that can provide from the radiopharmaceutic radiation shield in the medicine bottle 202 can be provided for medicine bottle holder 208 and plug 216.
Filling and induction system 200 also comprise filling shown in Figure 10 and injection device 220, and it provides from needle tubing 222 power that are supported in wherein and has filled or the dispense radioactive medicine.Before in being installed in filling and injection device 220, needle tubing 222 can be inserted in the needle tubing radiation shield 224.Radiation shield 224 can have one or more inner projection and/or other device that is fit to, help fixedly needle tubing 222 in shielding 224 thereby have at least, make shielding 224 and needle tubing 222 during normal process, can not separate, but needle tubing 222 can be from shielding 224 separately when expectation.Thereby in manual operations, handle and/or directly use needle tubing 222 with radiopharmaceutical injection in the patient time, radiation shield 224 be we can say the radiation shield that first level is provided.Needle tubing radiation shield 224 can be showed the external dimensions and/or the shape of standard, thus be convenient to according to suitable orientation fixedly needle tubing 222 fill and injection device 220 in.Thus, the needle tubing of different size can shield with the coupling syringe that all has general or similar external dimensions and/or shape and keep.The needle tubing holder 224 of shielding can be provided for the material of radiopharmaceutic radiation shield by tungsten, tungstenic plastics, lead and/or any other to be made.In addition, the shape and size of the needle tubing holder 224 of shielding can change (for example, thus satisfy the functional, ergonomics of different application and/or the shielding needs).
In the exemplary embodiments of Figure 10, filling and injection device 220 have band at the position of expectation and the dismountable sidewall 226 of the pair of U-shaped Flexible clamp 228 of orientation locking pin tube shield 224.Behind the needle tubing holder 224 that suitably location shields in clip 228, sidewall 226 can be located against the main body 230 of filling and injection device 220 subsequently again.Injection needle 234 can move by the slit 232 (Fig. 8) in the upper wall 248 of filling and injection device 220, and can be positioned in the centre bore 250.Injection needle 234 is preferred by upper wall also shown in Figure 9 248 and extension above it.
As shown in figure 12, needle tubing 222 can have the push rod 236 of band along end 238.Band is interconnected with the power translation electromechanical actuators 239 that is contained in filling and the injection device 220 along the size and dimension of end 238.Electromechanical actuators 239 is shown and comprises the plunger drive ram 241 that is connected with syringe driver 243 such as electro-motor.The work of syringe driver 243 can be by microprocessor 245 controls with memorizer 247.Microprocessor 245 can be connected to power interface 249, and it then is connected in power supply 251.Microprocessor 245 can also be connected to user interface 254 (Fig. 8), and user interface 254 can include but not limited to display screen 256 and/or input equipment 258, for example switch.Memorizer 247 can be used to store the relevant data of work with filling and injection device 220, it can include but not limited to be used to control the program of filling and/or injection work, the information relevant with radiopharmaceutical, information on other program or the non-program, patient information provides communication of getting back to the pharmacy etc.Long-distance Control 253 can be used to help to provide and the communicating by letter of pharmacy and manufacturer etc.Thereby display screen 256 can be introduced letter and/or pictorial display and show the data that include but not limited to fill with injection parameters, state, mounted component, radiopharmaceutical information, instruction, caution etc.The Long-distance Control 253 that is connected in power supply 251 can be used to replace user interface 254 alternatively, is used for that Long-distance Control is filled and the work of injection device 220.
Shown in Figure 12 and go for filling with the control of the type of injection device 220 and electromechanical actuators at " Injector " by name and transfer shown in assignee of the present invention's U.S. Patent Application Publication No.US 2004/0024361 A1 and introduce, U.S. Patent Application Publication No.US2004/0024361 A1 at this in full as with reference to introducing.
As shown in figure 11, container 206 can put from base wad 212, and is placed on 235 tops, upper end of injection and filling device 220.As shown in Figure 9, the container base 210 with radioactive shield 204 is positioned at chamber 240.Can be by screw thread 240 and 242 pairs on screw thread be rotated relative to one another together and subsequently, thus screw thread 240 and 242 engagements are got up, thereby container 206 and filling and injection device 220 engagements are got up.Screw thread 240 and 242 engagement make container 206 with respect to filling and injection device 220 translations, and the barrier film 244 on medicine bottle 202 lower ends is pierced through by the syringe needle 234 that passes wall opening 250 extensions.Thus, syringe needle 234 can be communicated with radiopharmaceutical 252 fluids in the medicine bottle 202.After container 206 and filling and injection device 220 were completely fixed together, barrier film 244 roughly was positioned at and is being close to upper wall 248.
In optional embodiment, container 206 can be that any fast rotational screw thread or any the quick of other are connected and disengaging gear with mechanical connection between filling and the injection device 220.In another embodiment, can cancel mechanical connection, for example, screw thread 240 and 242 makes container 206 be placed on simply on filling and injection device 220 upper ends 235.In the variation of this embodiment, can there be interference engagement between the wall in container 206 and chamber 246.
Filling and injection device 220 have preferably been introduced complete radiation shield around its sidewall and one or more end wall, it is provided for the material from radiopharmaceutic anti-radiation protection by tungsten, tungstenic plastics, lead and/or any other and makes.In addition, the needle tubing radiation shield 244 of encirclement needle tubing 222 provides another level to the radiating shielding of radiopharmaceutical.Thus, filling with radiopharmaceutical power in the process of needle tubing 222, or in the process of power injection of radioactive substances, dispose to fill and the people of injection device 220 has obtained for from the radiating shielding of radiopharmaceutical, only radioactivity leakage is potential may to be by centre bore 250.As previously mentioned, the personnel of nuclear medicine portion obey the regulation that " opening of living " is somebody's turn to do in processing, so this should not cause tangible radioactive exposure risk.
As shown in Figure 8, filling and injection device 220 can have printed label 260.In addition, filling and injection device 220 can have rfid device (" RF-ID ") label 262, and it can be the part of label 260 or independent with it.As shown in figure 12, microprocessor 245 can have and is used for reading data and/or writing the RF-ID interface 263 of data to it from RF-ID label 262.Medicine bottle 202 can have RF-ID label 259, and/or needle tubing 222 can have RF-ID label 261.The read/write device 255 that is fit to that can be connected in computer can be used for reading or to wherein writing data from one or more of RF-ID label 259,261,262.Computer 257 can be positioned at any suitable position, and is shown as the position (for example, medical facilities or pharmacy) that is positioned at filling and injection device 220 users.Thus, the data relevant with injection operation with radiopharmaceutical, needle tubing 222, container 206 and/or filling can be in fact being filled and each job step (if expectation) of injection device 220 reads or to wherein writing from RF-ID label 262, and these data can be by filling and microprocessor 245 acquisitions of injection device 220.In addition, one or more in RF-ID label 259,260,261 writes or can comprise remote computer according to the mode (as be known in the art) that is fit to and other compunication (for example, machine 257 as calculated) from the data that wherein read.
Thus, after determining to use specific radiopharmaceutical, by craft (for example, through user interface 254) and automatically (for example, in use read/write device 255 and the RF-ID label 259,262 one or more) one or both modes in, data from bottle label can be loaded in the microprocessor memory 247, and data can use read/write device 255 to be loaded in the syringe RF-ID label 261.These data can include, but not limited to following:
---prescription data.
---radiopharmaceutical, its brand, its supplier's etc. identification.
---by every milliliter of radioactive level of pharmacy measurement.
---radioactive decay rate.
---the time and date of calibration.
---medicine bottle uses historical record.
---the expection residual volume.
---effect duration.
Thereby the user can operate user interface 254 selects the part of these data to show.Thus, before padding, fill and the control of injection device 220 is checked automatically or optionally and included but not limited to data thereby can programme
---the effectiveness of effect duration and time.
---call back message.
---syringe installation and removal information, thus prevent to re-use syringe.
---whether in the past medicine bottle use and medicine bottle are fit to use at present.
---the to-fill procedure of the expectation residual volume by checking medicine bottle is renderd a service.
---measure activity level, rate of decay data, alignment time and date and prescribed dose and inject time and date based on the pharmacy, calculate and show and recommend packing volume.
---from radiopharmaceutical supplier's merchandising.
---information is inserted in drug packaging.
Can utilize user interface 254 manual programmings and/or be written to RF-ID label 262 (for example), thereby use the data that control is at least substantially filled and injection device 220 is worked can include, but not limited to following with the little processing 245 of cause through read/write device 255:
---each packing volume of filling.
---from using the historical medicine bottle residual volume that calculates.
---each date and time of filling.
---for each filling and radioactive level.
---any other treated to include but not limited to following by the information of user's input: patient's relevant information, and unit state, for example, service needs, and uses history etc.
Filling/injection device 220 can be filled needle tubing with very high-precision exact unit dose volume always in single padding.This can eliminate the time-consuming and multiple manual process of dose titration, and/or can reduce the user and be exposed to radiating risk.Thus, can reduce or eliminate substantially the waste and the very big excessive filling of loss of needle tubing, and/or disposal person can experience the more effectively use that the pharmacy is provided medicine bottle.
Filling and injection device 220 can be monitored the counter-pressure that produces during the power injection, and can suspend or end to have the injection of unusual high or low pressure.Low pressure can be represented empty needle tubing or leakage, and high pressure can be represented to block or possible overflowing.
Fill and injection device 220 by the pharmacy but not disposal person make and be used for filling the unit dose needle tubing, and needle tubing has been adopted in the application of RF-ID label, filled and injection device can be used for above-mentioned medicine bottle and needle tubing filling information that some or all arrives needle tubing RF-ID label.
In the exemplary embodiments of Fig. 9, needle tubing mounting structure 228 can pivot from the main body of filling and injection device 220 and open.In optional embodiment, the needle tubing mounting structure can separate from filling and injection device fully.In addition, shown in and in the exemplary embodiments introduced, needle tubing 222 has syringe needle 234.Yet, fill and injection device 220 can be used to fill and/or from the needle tubing dispense radioactive medicine of unequipped syringe needle.In this embodiment, can utilize intermediate connector with medicine bottle 202 interfaces and provide with its fluid and be communicated with.An example of the intermediate connector that is fit to can comprise the pin that is used on the membranous end of penetration of vials, and can be connected on the opposite end with no pintle-type nozzle be the joint (for example, through suitable luer joint) of the needle tubing of feature.In addition, among Figure 12, filling and injection device can be that rope or wireless (for example, battery power) are arranged.
Shown in and in the exemplary embodiments introduced, fill and injection device 220 is a hand-held device.Yet filling and injection device 220 can perhaps can be installed on support for what hand when the power injection of radioactive substances.Supporting mounting of syringe can be through accessory cables or control station remote activation, stop and/or working automatically after start-up by hand.
For illustrated embodiment, the radiation shield 204,216 that is used for container 206 is introduced to being installed in medicated cap 208 and pedestal 210 respectively.Other embodiment can comprise and can be contained in wholly or in part in medicated cap 208 and/or the pedestal 210, perhaps can for be connected in dividually medicated cap 208 and pedestal 210 separately and individual components, or other is fit to radiation shield of structure.
Figure 13 to 15 shows typical wireless filling and injection device 220.In the embodiment of Figure 13, wireless filling and injection device 220 can have energy storing device 302, Connection Block 300 and power controller 303.Advantageously, energy storing device 302 can support to fill the wireless work with injection device 220 some embodiment, introduces as following.Energy storing device 302 can comprise battery shown in Figure 14 304, or electric capacity 305 shown in Figure 15.Battery 304 can comprise for example lead-acid battery, lithium ion battery, lithium ion polymer battery, nickel-cadmium cell, nickel metal hydride battery or alkaline battery etc.Electric capacity 305 can comprise for example electrochemical capacitor, tantalum electric capacity, super capacitor, polyester film electric capacity, polypropylene capactive, polystyrene electric capacity, metallized polyester membrane capacitance, epoxy electric capacity, ceramic condenser, multi-layer ceramic capacitance, silver-mica capacitor, variable capacitance and/or air-core electric capacity.In other embodiments, energy storing device 302 can comprise the energy storage of other form, such as inductance; The mechanical energy memorizer, such as pressurized stream body cavity, flywheel or other kinetic energy storage device, spring, and/or some other elastomeric element; And/or the chemical energy memorizer, for example, resemble fuel cell.In near some embodiment that is suitable for nuclear magnetic resonance (MRI) machine using, energy storing device 302 can be substantially or iron content not fully.
By assembling, Connection Block 300 can be connected in fills and injection device 220 and energy storing device 302.Power controller 303 can partly or entirely be integrated in the microprocessor 245, and perhaps power controller 303 can be independent mutually with microcontroller 245.Power controller 303 can be communicated with energy storing device 302 through power interface 245.Power controller 303 can receive from energy storing device 302 with the relevant signal of various energy stored parameters, such as energy storage levels, temperature, charging rate or energy rate of release.For example, adopt the embodiment of electric capacity 304 can also comprise holding circuit, come the speed of limiting capacitance charging and/or discharge, limit other parts thus and bear big electric current.In certain embodiments, holding circuit can partly or entirely be integrated in the power controller 303.
In the work, power controller 303 can be monitored and control energy storage device 302.For example, power controller 303 can be monitored and/or the charging rate and/or the level of control energy storage device 302.Similarly, in certain embodiments, power controller 303 can be monitored and/or the velocity of discharge and/or the level of control energy storage device 302.For example, power controller 303 can determine whether that energy storing device 302 charges to predeterminated level, such as abundant charge or discharge, and transmits a signal to display 256 and/or Connection Block 300 is indicated this level.
In certain embodiments, power controller 303 and/or microprocessor 245 can determine whether energy storing device 302 has the energy level of the injection or the padding that are enough to drive requirement.If energy storing device 302 has enough energy levels and comes driving work, power controller 303 and/or microprocessor 245 can allow work.On the other hand, if energy storing device 302 has the energy level that is not enough to drive required work, power controller 302 and/or microprocessor 245 can send alarm signal, for example arrive display 256, and/or prevent that required work from carrying out.
Memorizer in memorizer 247 and/or energy storing device 302, power controller 303 or filling and injection device 220 other parts can write down the life cycle of energy storing device 302.For example, energy storing device 302 has filled and/or the number of times that discharges can write down and kept by memorizer.In certain embodiments, microprocessor 245 and/or power controller 303 can send a signal to display 256, the life-span of indication energy storing device 302.For example, inefficacy alarm signal and/or charge counting can send to and show by display 256.In certain embodiments, energy storing device 302 can comprise the information that is used to store its life cycle of indication, such as, for example build date, follow the tracks of number, charge counting, energy storing device type, manufacturer's identifying information, effect duration and/or remain the memorizer of memory capacity etc.In addition, in certain embodiments, energy storing device 302 can comprise and is used for the RFID circuit of communicating by letter with other device.
In certain embodiments, Connection Block 300 can be energy storing device 302 chargings.Optional or extraly, energy storing device 302 can receive from the energy of Connection Block 300 with external power, such as from the electrooptical device that is connected with injection device 220, hand-operated device or other manual powered device, and/or with the energy of filling the energy re-use device.
Figure 16 shows typical wireless filling and the injection device 306 that has energy storing device 302 and can be connected in Connection Block 300.Typical case wireless filling and injection device 306 can comprise the filling introduced previously and the feature of injection device.This wireless filling and injection device are characterised in that needle tubing assembly 308, shielding 310, actuated syringes 312, Connection Block electrical interface 314 and the Connection Block mechanical interface 315 of shielding.Connection Block electrical interface 314 can comprise many wires 332,333,334,335.In the present embodiment, needle tubing assembly 308 can comprise needle tubing 316 and shielding 318.The plunger rod 326 that shown needle tubing 316 can have pin 320, syringe 322, plunger 324 and have outer end 328.One or more fluids 330 can be arranged in the syringe 322 of needle tubing 316.For example, fluid 330 can comprise, for example radiopharmaceutical, contrast agent, saline solution, sign agent or other medicines.In certain embodiments, needle tubing 316 can be the single-stage needle tubing, have two-stage needle tubing, the spininess tube needle tubing of different fluid or have more than two-stage with more than two kinds of fluidic needle tubings in every grade.
Shielding 310,318 can comprise electromagnetic shielding, radiation shield, heat shielding or its combination.In certain embodiments, shielding 310,318 is characterised in that radiation shielding material, such as lead, depleted nuclear fuel, tungsten, tungstenic plastics etc.Optional or extraly, shielding 310,318 can comprise electromagnetic shielding material, such as copper, steel, conductive plastics or other conductive material of layer, net or other form.In a particular embodiment, the substantially or complete iron content not of shielding 310,318.Shielding 310 can encase needle tubing 316, actuated syringes 312 and/or energy storing device 302 fully; Substantially encase one or more in the parts 316,312,310; Perhaps part encases one or more in the parts 316,312,310.Similarly, shielding 318 can be all, substantially or partly encase needle tubing 316.It shall yet further be noted that some embodiment can not comprise shielding 310 and/or 318, this is not to say that any further feature of introducing also cannot omit herein.
Actuated syringes 312 can comprise that Piezoelectric Driving, linear motor, marmem, rack pinion system, worm gear and wheel assembly, planetary gear set, belt drives, gear drive, hand drive and/or air pressure drive.For example, among the embodiment of the Figure 18 of Jie Shaoing, actuated syringes 312 can comprise electro-motor and screw drive below.In certain embodiments, actuated syringes 312 can be fully, basic or iron content not partly.
At work, wireless filling and injection device 306 can cooperate with Connection Block 300.Specifically, Connection Block mechanical interface 315 can cooperate with complementary mechanical interface 338, and Connection Block electrical interface 314 can cooperate with complementary electric interface 336.The power supply power line 340 of can flowing through is through female connector 342,343,344,345, in male adapter 332,333,334,335.Power supply can flow into energy storing device 302.In certain embodiments, energy storing device 302 can charging when filling needle tubing 316.For example, when being energy storing device 302 chargings, actuated syringes 312 can apply power 331, and it moves down plunger 324 in needle tubing 322, thus with in the fluid suction needle tubing 322.During filling, in the original place or non-original place feedforward or feedback control can control filling speed and/or packing volume.
After energy storing device 302 charging or activating, wireless filling and injection device 306 can take off and are used for injection of radioactive substances 330, sign agent or other material from Connection Block 300, and disturb this process without any power line.Injection can filled with wireless filling and injection device 306 and carry out in the identical place of charging, and perhaps wireless filling and injection device 306 can be carried under charging and the state of filling and be used for using in other position.During injecting, energy can flow to actuated syringes 312 from energy storing device 302, and it can apply power 331 to the outer end 328 of push rod 326.Plunger 326 can actuation plunger 324 pass through syringe 332 and injecting fluid 330.During injecting, in the original place or non-original place feedover or feedback control, with the speed and/or the volume of control injection.
Figure 17 shows typical wireless filling and the injection device 348 with crosspointer pipe.This wireless filling and injection device 348 can comprise time needle tubing 350 and time actuated syringes 352.Inferior needle tubing 350 can shield and can comprise fluid 354, and it can be one or more fluids that list previously 330.In the present embodiment, this needle tubing 350 can shield in 310, but in other embodiments, inferior needle tubing 350 can be partially or completely outside shielding 310.In addition, crosspointer pipe 348 can be independently of one another or integrated or be unified into spininess tube needle tubing.
In the work, actuated syringes 352 can apply power 354 and drive fluid 354 outside inferior needle tubing 350 or in inferior needle tubing 350 to inferior needle tubing 350.In certain embodiments, actuated syringes 312 and time actuated syringes 352 can partly or entirely be integrated in the single actuated syringes.Perhaps, actuated syringes 312 and time actuated syringes 352 can be actuated syringes independently.During injection and/or filling, independently, in original place and non-original place, can be to by the flow velocity of wireless filling and injection device 348 injections or the fluid 330 of filling and/or 354 and/or volume feedovers and feedback control.
Figure 18 shows the typical actuated syringes 312 in wireless filling and the injection device 306.Shown actuated syringes 312 can comprise electro-motor 356, driver 358 and Linear actuator 360.Electro-motor 356 can be DC electro-motor or AC electro-motor, such as stepper motor.Shown driver 358 can comprise drivewheel 362, driven pulley 364 and belt 366.This Linear actuator 360 can have external thread rod, worm screw or screw rod 368, sleeve pipe 370, outer bar 372 and needle tubing interface 374.Driver 358 can be a deceleration transmission.For example, the diameter of driven pulley 364 can be greater than 1.5: 1,2: 1,3: 1,4: 1,5: 1,8: 1,12: 1 or bigger to the ratio of the diameter of drivewheel 362.Needle tubing interface 374 can comprise wideer outer end socket 376 and bar groove 378.In certain embodiments, some or all of these parts 356,358,360 can be substantially or iron content not fully.In addition, some or all of these parts 356,358,360 can partly, substantially or all be lived by shielding 310 shieldings.
In the work, electro-motor 356 can drive drivewheel 362.Along with drivewheel 362 rotations, belt 366 can rotate driven pulley 364.The rotation of driven pulley 364 can drive screw 368, and it can rotate in sleeve pipe 370.Sleeve pipe 370 can be a screw thread, makes the rotation of screw rod 368 to apply linear force to sleeve pipe 370.Linear slide mechanism can prevent sleeve pipe 370 rotations, allows sleeve pipe 370 in screw rod translation about in the of 368 simultaneously.Along with screw rod 368 rotations, outer bar 374 can be by the downward lead-screw 368 of sleeve pipe or the lead-screw 368 that makes progress.Outer bar 372 can move and through needle tubing interface 374 driven syringe 316 with respect to screw rod is linear.
Figure 19 is for adopting the flow chart referring to figs. 1 through the typical nuclear medicine procedures of one or more needle tubings shown in 18.As shown in the figure, process 380 is begun by the radiosiotope that is provided for nuclear medicine at square frame 382 places.For example, square frame 382 can comprise elution Tc 99m 99Tc from the radiosiotope emitter.At square frame 384 places, process 380 is by providing the concrete part that is suitable for to the patient, and for example organ is the radiosiotope sign agent (for example, antigen or other biology that is fit to guiding enzyme) of target and carrying out.At square frame 386 places, thereby process 380 is carried out for nuclear medicine provides radiopharmaceutical by combination radiosiotope and sign agent subsequently.In certain embodiments, radiosiotope can have the conatus of concentrating towards special organ or tissue, and radiosiotope can show the feature that need not to increase any additional sign agent thus.At square frame 388, process 380 can be carried out in needle tubing or other container by the radiopharmaceutical that extracts one or more dosage, and this other container is such as the container that is suitable in nuclear medicine facility or hospital radiopharmaceutical being administered into the patient.At square frame 390 places, process 380 is by injection or radiopharmaceutical and one or more fluid replacement of administration doses are carried out in the patient usually.Behind preselected time, process 380 is carried out (square frame 392) by the radiopharmaceutical of detection/imaging labelling patient organ or tissue.For example, square frame 392 can comprise and use gamma camera or other radiography imaging device, thus detect on brain, heart, liver, tumor, cancerous tissue or various other organ or pathological tissues, in or the radiopharmaceutical of boundary.
Figure 20 is used to provide wherein to be provided with the block diagram that radiopharmaceutical is used for the canonical system 394 of the needle tubing that uses in nuclear medicine application.For example, needle tubing can be referring to figs. 1 through one of in 18 needle tubings that illustrate and introduce.As shown in the figure, system 394 can comprise radioisotope elution system 396, and it has radioisotope generator 398, eluant supply container 400 and eluant and exports molten device or dose container 402.In a particular embodiment, eluant is exported molten device 402 can be in vacuum state, make the pressure difference between eluant supply container 400 and the eluant out-put container 402 be convenient to eluant (for example, saline) by radioisotope generator 398 with outwards by the circulation of eluate conduit to eluant out-put container 402.As eluant, for example saline solution circulates by radioactivity generator 398, and the circulation eluant cleans or radioisotope usually, for example, and Tc 99m 99Tc.For example, an embodiment of radioisotope generator 398 can comprise radiation shield shell (for example, plumbous cover), and it surrounds radioactive parent, such as molybdenum 99, absorbs the surface of the pearl of aluminum or resin-column.In radioisotope generator 398, parent molybdenum 99 is converted into metastable Tc 99m 99Tc through 67 hours half-life.The product isotope, Tc 99m 99Tc for example, the ratio parent radioisotope of maintenance radioisotope generator 398 in usually, for example molybdenum 99, and is not tight more.Therefore, the product radiosiotope, for example Tc 99m 99Tc can utilize the suitable eluant such as the anaerobic normal saline to extract or wash out.The eluant that outputs to eluant out-put container 402 from radioisotope generator 398 generally comprises eluant and washes out in the radioisotope generator 398 or radiosiotope that elution goes out.After in eluant generator 402, receiving the eluant of desired amount, can valve-off, and stop the output of eluant circulation and eluant.Introduce more in detail as following, thereby the product radiosiotope of extraction can make up diagnosis and the disposal of being convenient to the patient (for example, at the nuclear medicine facility) with the sign agent subsequently as required.
As shown in figure 20, system 394 can also comprise radiopharmaceutical production system 404, and its function is to make up radiosiotope 406 (for example, the use by radioisotope elution system 396 obtain Tc 99m 99Tc solution) and sign agent 408.In certain embodiments, this radiopharmaceutical production system 404 can be called or comprise " tool kit " alleged in the prior art (for example, be used for preparation diagnosis with radiopharmaceutic Technescan tool kit).Once more, the sign agent can comprise the various materials that are attracted to or indicate patient's specific part (for example, organ, tissue, tumor, cancerous cell etc.).As a result, radiopharmaceutical production system 404 produces and maybe can be used to produce the radiopharmaceutical that comprises radiosiotope 406 and sign agent 408, shown in square frame 410.Shown in system 394 can also comprise radiopharmaceutical distribution system 412, it is convenient to use with in medicine bottle shown in radiopharmaceutical suction Fig. 1 to 18 or the needle tubing 414.In a particular embodiment, each parts of this system 814 and function can be arranged in the pharmacy, and its preparation is used for the radiopharmaceutic needle tubing 414 that nuclear medicine application is used.For example, needle tubing 414 can prepare and be transported to medical facilities, is used for using in patient's diagnosis and disposal.
The block diagram of the typical nuclear medicine imaging system 416 of the radiopharmaceutic needle tubing 414 that Figure 21 provides for the system 394 that adopt to use Figure 20.As shown in the figure, nuclear medicine imaging system 416 comprises radioactive detector 418, and it has flasher 420 and photodetector 422.The sign organ radiation emitted 428 of response in the patient 426, flasher 420 emissions can and be converted into the light of the signal of telecommunication by photodetector 422 inductions.Though not shown, imaging system 416 can also comprise collimator, its collimation is towards the radiation 424 of radiation detector 418.Shown in imaging system 416 can also comprise detector acquisition circuitry 428 and image processing circuit 430.Detector acquisition circuitry 428 is controlled obtaining from the signal of telecommunication of radiation detector 418 usually.Image processing circuit 430 can be used to handle the signal of telecommunication, carries out and checks agreement etc.Shown in imaging system 416 can also comprise user interface 432, thereby be convenient to other parts that the user handles image processing circuit 430 and imaging system 416.As a result, imaging system 416 produces the image 434 of patient's 426 internal labeling organs.
When introducing the element of each embodiment of the present invention, " one ", " one " " being somebody's turn to do " and " described " are intended to expression one or more elements.Are intended to term " formation ", " comprising " and " having " to comprise and represent to have the extra element that lists beyond the element.In addition, use " top ", " end ", " on ", the variation of D score and these terms is for convenience, but do not require parts carried out any specific orientation.
Though the present invention can allow various changes and optional form, by example mode is introduced and is described specific embodiment in detail at this in the accompanying drawings.Yet, should understand the present invention and should not be limited to particular forms disclosed.On the contrary, the present invention should cover that institute in the spirit and scope of the invention that limited by following claims changes, equivalent and substitute.
Claims (81)
1. radiopharmaceutical equipment comprises:
First computer;
Has first electric connector with the wired connection of first computer; And
Radiopharmaceutical pigs comprises radiation shielding material and comprises:
Second computer; And
Be installed on the radiopharmaceutical pigs and be electrically connected at second electric connector of second computer, wherein first electric connector can be connected in second electric connector, thereby electrically connects first computer and second computer of radiopharmaceutical pigs.
2. equipment as claimed in claim 1 also comprises the base unit that supports first electric connector.
3. equipment as claimed in claim 1 also comprises the control unit that supports first computer.
4. equipment as claimed in claim 3, wherein control unit also supports first electric connector.
5. equipment as claimed in claim 3 also comprises being electrically connected at control unit and by the dose calibrator of its control.
6. radiopharmaceutical equipment comprises:
Radiopharmaceutical pigs comprises radiation shielding material and comprises:
First computer; And
Be electrically connected at first electric connector of first computer;
Be configured to the base unit of mechanical support radiopharmaceutical pigs;
Second computer; And
On base unit and have with second of the wireless connections of second computer and electrically connect, thereby second electric connector can be connected in second computer and first computer that first electric connector electrically connects radiopharmaceutical pigs.
7. equipment as claimed in claim 6 also comprises the control unit that supports second computer.
8. equipment as claimed in claim 7 also comprises the dose calibrator that is electrically connected at control unit and is subjected to its control.
9. radiopharmaceutical pigs comprises:
Comprise at least a radioactive shielding material and have the main body that is applicable to the tank that holds radiopharmaceutical container;
The lid that comprises at least a radioactive shielding material, thus lid be connected in releasedly main body with container closure in jar; And
The computer that comprises memorizer and input/output device, computer one of are installed in main body and the lid.
10. radiopharmaceutical pigs as claimed in claim 9, also comprise be electrically connected at computer and be installed in main body and lid in one of outer surface on first electric connector, wherein first electric connector is installed on the end face of main body.
11. radiopharmaceutical pigs as claimed in claim 9, also comprise be electrically connected at computer and be installed in main body and lid in one of outer surface on first electric connector, wherein first electric connector is installed on the end face of lid.
12. radiopharmaceutical pigs as claimed in claim 9, also comprise be electrically connected at computer and be installed in main body and lid in one of outer surface on first electric connector, wherein first electric connector is installed on the end face of main body, and input/output device is installed on the main body.
13. radiopharmaceutical pigs as claimed in claim 9, also comprise base unit, be electrically connected at computer and be installed in main body and lid in one of outer surface on first electric connector, and second electric connector that supports by base unit, second electric connector can be connected with first electric connector.
14. an equipment that is used to preserve with injection of radioactive substances comprises:
Needle tubing comprises the plunger and the port of export;
Jar, comprising:
Be used to hold needle tubing and comprise the main body that radioactive shielding material is provided, and the exit opening that is used to accept the port of export of needle tubing on main body one end, and
The tank clip, it can be operated the contact needle tubing and needle tubing is remained in the jar; And
The lid of cover outlet opening, thus lid can the movable port of export that opens wide exit opening and needle tubing.
15. the described equipment of claim 14, wherein lid comprises the material that radiation shield is provided.
16. the described equipment of claim 14, wherein plunger comprises the material that radiation shield is provided.
17. the described equipment of claim 14, wherein lid is slidably mounted on the end of main body.
18. the described equipment of claim 14, wherein lid is pivotably mounted on the end of main body.
19. the described equipment of claim 14, wherein lid utilization activity fastener is installed on the end of main body.
20. the described equipment of claim 14, wherein the lid activity is coupling on the end of main body.
21. the described equipment of claim 14, wherein lid comprises that activity is coupled to the end cap of needle tubing one end.
22. the described equipment of claim 14, wherein jar comprises that also the band that extends from the opposite end of main body is along end.
23. the described equipment of claim 22 can be operated from the power injector of needle tubing dispense radioactive medicine thereby band wherein jar is adapted to fit into along end.
24. the described equipment of claim 14, thereby wherein jar is adapted to fit into and can operates from the hand-held power injector of needle tubing dispense radioactive medicine.
25. an equipment that is used to preserve with injection of radioactive substances comprises:
Needle tubing comprises the plunger and the port of export; And
Jar, comprising:
Tubular body is used to hold needle tubing and comprises:
The material of radiation shield is provided, and
Be used to accept the exit opening on tubular body one end of the port of export of needle tubing,
Make and cover the lid of exit opening by the material that radiation shield is provided, thereby lid can the movable port of export that opens wide exit opening and needle tubing; And
The hand-held power injector that supports jar, thus hand-held power injector can be operated mobile plunger and from needle tubing dispense radioactive medicine.
26. an equipment that is used to preserve with injection of radioactive substances comprises:
Needle tubing comprises:
Have first port of export and be suitable for holding radiopharmaceutic first chamber;
Be positioned at first plunger of first intracavity;
Have second port of export and be used to hold and the biocompatible liquid of radiopharmaceutical, and
Be arranged in second plunger in second chamber; And
Jar, comprising:
Tubular body is used to hold needle tubing and comprises:
The material of radiation shield is provided, and
Near first and second ports of export of needle tubing exit opening; And
Cover the lid of first and second ports of export, thereby lid can the movable port of export that opens wide exit opening and needle tubing.
27. equipment as claimed in claim 26, wherein lid comprises the material that radiation shield is provided.
28. equipment as claimed in claim 26, wherein needle tubing can be supported in the tubular body by retractable clip.
29. equipment as claimed in claim 26, wherein needle tubing can be supported in the tubular body by the interference engagement with the part of tubular body.
30. one kind is used for filling the equipment of needle tubing from holding radiopharmaceutic medicine bottle, comprises:
Container comprises:
Comprise pedestal by the opening of its extension,
Block, and
Be suitable for the radiation shield that regional base closed except the pedestal split shed holds radiopharmaceutic medicine bottle; And
Hand-held power is filled and injection device, comprising:
The main body of the opening that comprises sidewall and extend by sidewall; And
Be suitable for supporting the mounting structure of needle tubing, the syringe needle of needle tubing is positioned at the opening of main body, and the opening in sidewall storage container and the positioning pedestal is right after the opening in the main body, thereby makes the radiopharmaceutical in the medicine bottle be communicated with the syringe needle fluid of needle tubing.
31. equipment as claimed in claim 30, thereby also comprise the discharged coupling that to operate attachment cap and pedestal.
32. equipment as claimed in claim 30, thereby also comprising operating connects the discharged coupling of container to filling and injection device.
33. equipment as claimed in claim 30 also comprises being used for the base supports holding pedestal and comprise the radiation shield of the opening that covers pedestal.
34. equipment as claimed in claim 30 also comprises the radiation shield that can be positioned in the mounting structure and be suitable for centering on substantially needle tubing.
35. equipment as claimed in claim 30, wherein main body also comprises except the basic radiation shield around main body fully in main body split shed zone.
36. one kind is used for from having radiopharmaceutical being sealed in the equipment that wherein membranous medicine bottle is filled the needle tubing with syringe needle, this equipment comprises:
Container comprises:
Vessel port, this container are suitable for fixedly that medicine bottle makes vessel port near the barrier film of medicine bottle, and
Be suitable for holding the radiation shield of radiopharmaceutic medicine bottle except the diaphragm area complete closed; And
Hand-held power is filled and injection device, comprising:
The main body that comprises opening; And
Be suitable for supporting the mounting structure of needle tubing with syringe needle, the syringe needle of needle tubing is positioned at the opening of main body, thereby the opening in the main body of main body receiving vessel location is right after vessel port, and makes and the needle pierces barrier film of needle tubing the radiopharmaceutical in the medicine bottle is communicated with the needle tubing fluid.
37. equipment as claimed in claim 36, wherein container also comprises:
Pedestal; And
The medicated cap that can be connected with pedestal.
38. equipment as claimed in claim 36, wherein mounting structure can be with respect to subject activity.
39. equipment as claimed in claim 36 also comprises the support that is used for storage container and comprises the radiation shield of covering container opening.
40. equipment as claimed in claim 36 also comprises the radiation shield that can be positioned in the mounting structure and be suitable for centering on substantially needle tubing.
41. equipment as claimed in claim 36, wherein main body also comprises the radiation shield that centers on Subject Extension except main body split shed zone substantially fully.
42. one kind is used for filling the equipment of needle tubing from holding radiopharmaceutic medicine bottle, this needle tubing has syringe needle and push rod, and this equipment comprises:
Comprise radiation shield and be suitable for fixedly holding the container of radiopharmaceutic medicine bottle; And
Hand-held power is filled and injection device, comprising:
The main body that comprises the opening that extends through sidewall;
Be suitable for supporting the mounting structure of needle tubing, the syringe needle of needle tubing is arranged in the opening of main body,
This main body storage container also is suitable for making the radiopharmaceutical in the medicine bottle to be communicated with needle tubing syringe needle fluid, and
Thereby be suitable for operating the electromechanical device that the needle tubing push rod utilizes the radiopharmaceutical filling needle tubing in the medicine bottle.
43. equipment as claimed in claim 42 also comprises:
Can be operatively connected controller to electromechanical device; And
Comprise that being connected in controller is used to import and the input equipment of video data and the user interface of display.
44. equipment as claimed in claim 42, also comprise be installed in fill and injection device on and with the RF-ID label of controller electrical communication.
45. equipment as claimed in claim 42 also comprises being used to hold the base supports of pedestal and comprising the radiation shield that covers the pedestal split shed.
46. equipment as claimed in claim 45 also comprises the radiation shield that can locate and be suitable for to center on substantially needle tubing in mounting structure.
47. equipment as claimed in claim 45, wherein main body also comprises the radiation shield that centers on Subject Extension except main body split shed zone substantially fully.
48. one kind from having the method for radiopharmaceutical sealing membranous medicine bottle within it being filled needle tubing, this method comprises:
Provide to have the container that surrounds the radiation shield of medicine bottle except diaphragm area, thus container fixedly medicine bottle locate the barrier film adjacent vessel opening of medicine bottle;
Thereby the syringe needle that loads needle tubing location needle tubing in hand-held power filling and injection device is in the opening of filling and injection device;
Thereby with container be positioned at fill and the injection device top is positioned at the barrier film of medicine bottle to fill and the injection device opening above; And
Move relative to each other container and filling and injection device, thus make needle tubing the needle pierces medicine bottle barrier film and the radiopharmaceutical in the medicine bottle is communicated with the needle tubing fluid.
49. method as claimed in claim 48, wherein before loading needle tubing, this method also comprises needle tubing is placed into except syringe needle and needle tubing push rod and centers on substantially in the radiation shield of needle tubing.
50. method as claimed in claim 49 is wherein loaded needle tubing and is also comprised:
Electromechanical actuators in needle tubing push rod and filling and the injection device is operably connected; And
Thereby the mobile needle tubing push rod of operating motor tool driver also is used to fill needle tubing from the radiopharmaceutical of medicine bottle.
51. method as claimed in claim 50 also comprises:
From filling and injection device take off container thereafter;
Connect the needle tubing syringe needle to the pipe that is connected with the patient; And
Thereby thereby the mobile needle tubing push rod of operating motor tool driver is injected into the patient with radiopharmaceutical from needle tubing.
52. method as claimed in claim 51 also comprises:
From filling and injection device take off container thereafter; And
Thereby the manual operations needle tubing injects the patient with radiopharmaceutical.
53. a shielding cordless injector assembly comprises:
Syringe;
Be at least partially disposed on syringe radiation shield on every side;
Be connected in the driver of syringe; And
Be connected in the energy storing device of driver.
54. assembly as claimed in claim 53, wherein energy storing device comprises battery.
55. assembly as claimed in claim 54, wherein battery comprises lithium.
56. assembly as claimed in claim 54, wherein battery comprises nickel.
57. assembly as claimed in claim 53, wherein energy storing device comprises electric capacity.
58. assembly as claimed in claim 57, wherein electric capacity comprises super capacitor.
59. assembly as claimed in claim 53 comprises the energy controller that is connected with energy storing device.
60. assembly as claimed in claim 53, wherein radiation shield comprises the tungstenic plastics.
61. assembly as claimed in claim 53 comprises the radiopharmaceutical that is arranged in the syringe.
62. assembly as claimed in claim 53 comprises Connection Block.
63. assembly as claimed in claim 62 wherein shields cordless injector and comprises first electric connector, and Connection Block is included in second electric connector that cooperates with first electric connector of bonding station of shielding cordless injector.
64. assembly as claimed in claim 62, wherein Connection Block comprises independent current source.
65. assembly as claimed in claim 62, wherein Connection Block is coupled to movable stand, spiral arm, sick bed, imaging device or its combination.
66. a power medical fluid injecting systems comprises:
Needle tubing;
Be connected in the actuated syringes device of needle tubing; And
Be connected in the electric capacity of actuated syringes device.
67. as the described system of claim 66, electric capacity or actuated syringes device or both iron content not roughly wherein.
68. as the described system of claim 66, wherein container comprises super capacitor.
69. as the described system of claim 66, wherein the actuated syringes device comprises screw drive.
70. as the described system of claim 66, wherein the actuated syringes device comprises Piezoelectric Driving.
71., comprise the energy controller that is connected in electric capacity as the described system of claim 66.
72., comprise being arranged on radiation shield or electromagnetic shielding or its combination on every side of needle tubing major part as the described system of claim 66.
73., comprise Connection Block with the electrical and mechanical connector that matches with the portable syringe unit that comprises actuated syringes device and electric capacity as the described system of claim 66.
74. as the described system of claim 73, wherein Connection Block is coupled to movable stand, spiral arm, sick bed, imaging device or its combination.
75., comprise the radiopharmaceutical, contrast agent, medical fluid or its combination that are arranged in the needle tubing as the described system of claim 66.
76. an operational approach that is used for the medical fluid needle tubing, this method comprises:
Storage of electrical energy in cordless injector;
Environment is shielded from the active material in the cordless injector; And
Utilize electric energy to drive active material stream.
77. as the described method of claim 76, wherein storage of electrical energy comprises that through Connection Block be battery charge in the cordless injector.
78. as the described method of claim 76, wherein storage of electrical energy is included as the electric capacity charging in the cordless injector.
79., wherein shield environment and comprise that utilization comprises that the shielding of tungsten and plastics shields environment as the described method of claim 76.
80., wherein drive radiopharmaceutical stream and comprise flow velocity and the flow of controlling active material as the described method of claim 76.
81., comprise detection, handle or produce and the relevant view data of injection active material in object as the described method of claim 76.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68125305P | 2005-05-16 | 2005-05-16 | |
| US60/681,253 | 2005-05-16 | ||
| US60/681,330 | 2005-05-16 | ||
| US60/681,254 | 2005-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101184518A true CN101184518A (en) | 2008-05-21 |
Family
ID=39449433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800170542A Pending CN101184518A (en) | 2005-05-16 | 2006-05-16 | Radiopharmaceutical pigs and portable powered injectors |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101184518A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102256642A (en) * | 2008-12-16 | 2011-11-23 | 松下电器产业株式会社 | Medication administering device |
| CN104093359A (en) * | 2011-11-23 | 2014-10-08 | 通用电气公司 | Systems and methods for communicating dose calibration information |
| CN105025975A (en) * | 2013-03-07 | 2015-11-04 | 拜耳医疗保健股份有限公司 | Modality work list system |
| CN105209931A (en) * | 2013-03-13 | 2015-12-30 | 马林克罗特有限公司 | Systems and methods for assaying an eluate for technetium and molybdenum content |
| CN105582592A (en) * | 2009-04-09 | 2016-05-18 | 利贝尔-弗拉施姆有限公司 | Medical fluid delivery system with RFID-equipped wand |
| CN105682705A (en) * | 2013-10-30 | 2016-06-15 | 北极星医疗放射性同位素有限责任公司 | Product cartridge for radionuclide |
| CN106110518A (en) * | 2010-06-04 | 2016-11-16 | 拜耳医药保健有限责任公司 | The system and method that multiple dose radiopharmaceutical in radiopharmaceutical syringe uses for planning and monitoring |
| CN111386136A (en) * | 2017-10-31 | 2020-07-07 | 益首药物治疗股份公司 | Monitoring of disposable injection devices |
| CN111615409A (en) * | 2017-11-17 | 2020-09-01 | 科斯卡家族有限公司 | System and method for fluid delivery manifold |
| US11324892B2 (en) | 2013-01-29 | 2022-05-10 | Sanofi-Aventis Deutschland Gmbh | Electronic module and drug delivery device |
| CN114983818A (en) * | 2022-05-31 | 2022-09-02 | 四川先通原子医药科技有限公司 | Radiopharmaceutical injection system and uses thereof |
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- 2006-05-16 CN CNA2006800170542A patent/CN101184518A/en active Pending
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| US8771233B2 (en) | 2008-12-16 | 2014-07-08 | Atsushi Watanabe | Medication administering device |
| CN102256642A (en) * | 2008-12-16 | 2011-11-23 | 松下电器产业株式会社 | Medication administering device |
| CN105582592B (en) * | 2009-04-09 | 2019-05-31 | 利贝尔-弗拉施姆有限公司 | Medical fluid delivery system with the stick equipped with radio frequency identification |
| CN105582592A (en) * | 2009-04-09 | 2016-05-18 | 利贝尔-弗拉施姆有限公司 | Medical fluid delivery system with RFID-equipped wand |
| CN106110518A (en) * | 2010-06-04 | 2016-11-16 | 拜耳医药保健有限责任公司 | The system and method that multiple dose radiopharmaceutical in radiopharmaceutical syringe uses for planning and monitoring |
| CN104093359A (en) * | 2011-11-23 | 2014-10-08 | 通用电气公司 | Systems and methods for communicating dose calibration information |
| US11324892B2 (en) | 2013-01-29 | 2022-05-10 | Sanofi-Aventis Deutschland Gmbh | Electronic module and drug delivery device |
| US11707573B2 (en) | 2013-01-29 | 2023-07-25 | Sanofi-Aventis Deutschland Gmbh | Electronic module and drug delivery device |
| CN105025975A (en) * | 2013-03-07 | 2015-11-04 | 拜耳医疗保健股份有限公司 | Modality work list system |
| CN105209931A (en) * | 2013-03-13 | 2015-12-30 | 马林克罗特有限公司 | Systems and methods for assaying an eluate for technetium and molybdenum content |
| CN105682705A (en) * | 2013-10-30 | 2016-06-15 | 北极星医疗放射性同位素有限责任公司 | Product cartridge for radionuclide |
| CN105682705B (en) * | 2013-10-30 | 2019-07-19 | 北极星医疗放射性同位素有限责任公司 | Product box for radionuclides |
| CN111386136A (en) * | 2017-10-31 | 2020-07-07 | 益首药物治疗股份公司 | Monitoring of disposable injection devices |
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Open date: 20080521 |