CN101099714A - Antibiotic hand-care liquid compound and preparing method - Google Patents

Abstract

The present invention discloses a formula of antiseptic hand-protecting liquor and its preparation method. It is made up by using benzalkonium bromide cationic active group as main active component and adding other surfactant, conditioner and adjuvant as auxiliary components through a certain preparation process. Said antiseptic hand-protecting liquor has three functions of killing bacterial, cleaning skin and moistening skin.

Description

A kind of antibiotic hand-care liquid compound and preparation method

One, technical field:

The present invention relates to a kind of disposable foam type antibiotic hand-care liquid and preparation method thereof with sterilization, cleaning and the three-in-one function of skin moistening.

Two, background technology:

Along with reform deeply and the developing by leaps and bounds of national economy, people's economic activity contacts are frequent, the frequency of amusement and travel is also more and more higher, and is bright from the medical science data sheet, a lot of its routes of transmission of pathogenic bacterium mainly contact with pathogen with air and on infected.Thereby at first to avoid colliding the article that polluted in outdoor activity, contacts and the amusement and travel process, priorly to accomplish the duty sterilization of washing one's hands, stop because of the hands contact infected.The kind of the handwashing liquid of the usefulness of washing one's hands, handguard liquid is many, but this series products on the market mainly is based on decontamination, and some bottle sticks and indicates antibiotic, bacteriostasis, and being actually does not have or effect seldom.To the quality testing of Shanghai commercial anti (pressing down) bacterium lotion, the antibacterial qualification rate is 53.1% as a result according to Chinese Disinfection magazine (2006.1 phase) report,, antibacterial class lotion 46.9%.Report from existing patent documentation, some liquid handwashing liquid of having developed have defective in various degree.

The CN1112157A skin care hand cleaning liquid is with the handwashing liquid of alkylol polyoxyethylene ether, betanin, its polyoxyethylenated alcohol sulfuric acid ester potassium of alkane, glycerol, ethanol preparation, with 1-3 times of double as leave of 10-90% ethanol dilution handwashing liquid, contain so many alcohols handwashing liquid, can cause stimulation skin and mucosa; This antibacterial of patent of invention ZL02126050.8 is formulated by chlorhexidine acetate, benzalkonium bromide, glycerol etc., although the obvious sterilization effect is arranged, but contain glycerol, skin had stimulation, the product that other enterprise produced, example, the patent EP0843002 of Japanese Kao company is the foam type desinfactant detergent, it is to be main active ingredient by benzalkonium chloride, hibitane; The patent JP11263995 of Japan Shiseido company is the good detergent of clean skin bactericidal effect, and it is to be main active ingredient by benzalkonium chloride, trichlorine to hexichol, hibitane, and shown production cost is higher relatively.

Three, summary of the invention:

The objective of the invention is to overcome above-mentioned defective, what a kind of alcohol-free composition was provided is main active ingredient with benzalkonium bromide, and sterilizing rate moment can reach more than 99.9%, has the leave antibiotic hand-care liquid of sterilization, cleaning and skin moistening three big functions.The present invention is achieved by following technical proposals: it is characterized in that: its prescription (by weight percentage) is to form with following component:

Benzalkonium bromide 0.1-0.2%,

Surfactant 1-10%,

Conditioner 0.1-1%,

Auxiliary agent 0.5-5%,

Adjuvant 0.5-2%,

All the other be deionized water,

Above raw material is commercially available;

Its preparation method: take by weighing each component: benzalkonium bromide is water-soluble by prescription, stir, add successively again surfactant, conditioner, again add water and stir after, after adding the stirring of PCMX antiseptic and allantoin again, solution is heated to 70-80 ℃ is stirred to dissolving fully, cool off Yi Bian place.Get and be dissolved in water again after another container takes by weighing citric acid and HPMC mixing, get a container again and add low amounts of water dissolving triethanolamine, the water-soluble remittance of another container is poured in the container of benzalkonium bromide and go, ceaselessly stir until complete mix homogeneously, survey pH value, add triethanolamine solution levelling PH=5.5-6.5 then as one feels fit, solution is cooled to add below 35 ℃ flavouring agent and coloring agent in the container, cool to room temperature gets final product fill; Described conditioner is two or more in dimethyl dodecyl amine oxide, cocamidopropyl propyl amide amine oxide, the CH3-(CH2)13N(CH3)2-O; Described auxiliary agent is an allantoin; Described auxiliary agent also comprises triethanolamine and hydroxypropyl emthylcellulose (HPMC); Described adjuvant is PCMX (4-chloro-3,5-xylenol) efficient antiseptic and compound preservative GMP-1 (by diazonium alkyl imidazoline urine, the mixture aqueous solution of third fat, propylene glycol preparation); Described adjuvant also comprises citric acid, flavouring agent and food coloring; Described surfactant be in dodecyldimethylammonium hydroxide inner salt, hexadecyltrimethylammonium chloride, month Fructus Citri tangerinae base imidazolinium betaine, the cocamido propyl betaine more than three kinds or three kinds;

Foam type antibiotic hand-care liquid of the present invention has sterilization, cleaning, skin protection three big functions, mainly is to be given by surfactant, conditioner, auxiliary agent and main active ingredient in the prescription, is summarized as follows:

From being situated between into the cation activity group, this product has sterilization and detergent power concurrently to benzalkonium bromide in aqueous solution, and effect is strong and fast.Be widely used in aspects such as sterilization, sterilization, anticorrosion, de-sludging, stable in properties is easy to preserve, free from environmental pollution.

Surfactant in the prescription mainly is two property ionic surface active agents, good with other surfactant compatibility, stable in wider PH scope, little and have washing, detergency ability, antistatic and a bactericidal action to the zest of eyes, skin, flexibility is good, foaminess is good, and safety non-toxic, biological degradability are also fine.

The dimethyl dodecyl amine oxides that conditioner in the prescription is selected for use etc. belong to weak ionic surface active agent, and scourability is good, and foam is many and stablize; the gentle zest of character is low; and having good flexibility, can be used as foam enhancing and move infusion, is effective skin smoothing, emollient; nontoxic, biological degradability good; need not the water flushing after the use, safe in utilization, convenient, nontoxic, nonirritant (soft composition) has protection skin; the feel exquisiteness, sterilization and detergency are strong.And effect is fast, and moment is removed antibacterial rate 〉=99.9%, it is behind people ante cibum, the lavatory, at home tourism carry, cheap a kind of new product.

Four, the specific embodiment:

Be example below, the present invention be further described with 2 embodiment:

Its prescription (by weight percentage) is to form with following component:

Benzalkonium bromide 0.15%,

Dimethyl dodecyl amine oxide 1%

Dodecyldimethylammonium hydroxide inner salt 0.6%

The basic imidazolinium betaine 0.4% of moon Fructus Citri tangerinae,

Cocamidopropyl propyl amide amine oxide 0.1%,

Dimethyl dodecyl amine oxide 0.1%,

PCMX antiseptic 1% or alternative with compound preservative GMP-1;

Allantoin 0.1%

Citric acid 0.05%

Hydroxypropyl emthylcellulose (HPMC) 0.05%

Deionized water 96.45%

Embodiment 1:

Take by weighing each component by formula ratio, at first with in the molten deionized water in the A container of benzalkonium bromide, after stirring, add dodecyldimethylammonium hydroxide inner salt, hexadecyltrimethylammonium chloride, month Fructus Citri tangerinae base imidazolinium betaine, dimethyl dodecyl amine oxide, cocamidopropyl propyl amide amine oxide successively, a kind of component of every adding all will ceaselessly stir, and adds the PCMX antiseptic again, and the back that stirs adds allantoin, then this container is warmed to 70-80 ℃, stirs the back and place cooling.

Get second container and take by weighing citric acid and HPMC, behind the two mix homogeneously, add the small amount of deionized water dissolving again, be stirred to dissolving fully.

Get the 3rd container and take by weighing triethanolamine, add a small amount of water-soluble Jie, stir.With merging in the A container in second container, strengthen being stirred to and fully evenly survey pH value, adding triethanolamine solution levelling pH value then as one feels fit is 5.5-6.5.Cool off while stirring,, add flavouring agent and coloring agent, stir when solution is cooled to below 35 ℃, cool to room temperature, fill gets final product.

Embodiment 2:

The benzalkonium bromide of formula ratio is dissolved in the aqueous solution of compound preservative GMP-1 and allantoin, be stirred to dissolving fully, add dodecyldimethylammonium hydroxide inner salt more successively, cocamido propyl betaine, the basic imidazolinium betaine of moon Fructus Citri tangerinae, dimethyl dodecyl amine oxide, CH3-(CH2)13N(CH3)2-O, when adding each component, need constantly stir until evenly, add another kind of component again, the low amounts of water dissolving will be added behind HPMC and the citric acid mix homogeneously, stir the back fully evenly, pour into then in the above-mentioned solution, mix, add triethanolamine aqueous solution levelling PH=5.5-6.5 again.Add flavouring agent and food coloring, after stirring, after static a few hours, fill gets final product.

Claims (8)

1, a kind of antibiotic hand-care liquid compound and preparation method is characterized in that:

Its prescription (by weight percentage) is to form with following component:

Benzalkonium bromide 0.1-0.2%,

Surfactant 1-10%,

Conditioner 0.1-1%,

Auxiliary agent 0.5-5%,

Adjuvant 0.5-2%,

All the other be deionized water,

Above raw material is commercially available.

2, a kind of antibiotic hand-care liquid according to claim 1 and preparation method: it is characterized in that comprising the following steps: to take by weighing each component: benzalkonium bromide is water-soluble by prescription, stir, add successively again surfactant, conditioner, again add water and stir after, after adding the stirring of PCMX antiseptic and allantoin again, solution is heated to 70-80 ℃ is stirred to complete molten Jie, cool off Yi Bian place.Get and be dissolved in water again after another container takes by weighing citric acid and HPMC mixing, get a container again and add a small amount of water-soluble Jie's triethanolamine, the water-soluble remittance of another container is poured in the container of benzalkonium bromide and go, ceaselessly stir until complete mix homogeneously, survey pH value, add triethanolamine solution levelling PH=5.5-6.5 then as one feels fit, solution is cooled to add below 35 ℃ flavouring agent and coloring agent in the container, cool to room temperature gets final product fill.

3, a kind of antibiotic hand-care liquid compound according to claim 1 and preparation method is characterized in that: described conditioner is two or more in dimethyl dodecyl amine oxide, cocamidopropyl propyl amide amine oxide, the CH3-(CH2)13N(CH3)2-O.

4, a kind of antibiotic hand-care liquid compound according to claim 1 and preparation method is characterized in that: described auxiliary agent is an allantoin.

5, a kind of antibiotic hand-care liquid compound according to claim 4 and preparation method is characterized in that: described auxiliary agent also comprises triethanolamine and hydroxypropyl emthylcellulose (HPMC).

6, a kind of antibiotic hand-care liquid compound according to claim 1 and preparation method, it is characterized in that: described adjuvant is a PCMX (4-chloro-3, the 5-xylenol) efficient antiseptic and compound preservative GMP-1 (by diazonium alkyl imidazoline urine, the mixture aqueous solution of third fat, propylene glycol preparation).

7, a kind of antibiotic hand-care liquid compound according to claim 6 and preparation method, it is characterized in that: described adjuvant also comprises citric acid, flavouring agent and food coloring.

8, a kind of antibiotic hand-care liquid compound according to claim 1 and preparation method is characterized in that: described surfactant be in dodecyldimethylammonium hydroxide inner salt, hexadecyltrimethylammonium chloride, month Fructus Citri tangerinae base imidazolinium betaine, the cocamido propyl betaine more than three kinds or three kinds.