CN101066317A - 治疗附睾炎性不育症的中药制剂 - Google Patents
治疗附睾炎性不育症的中药制剂 Download PDFInfo
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Abstract
本发明涉及治疗附睾炎性不育症的中药制剂，它是以荔枝核、夏枯草、桃仁和红花等10多味中草药为原料。具有益气散寒，理气活络的功效。本发明是在传统的中医辨证治疗的基础上结合现代最新科研成果研制而成的。本发明的目的是提供治疗附睾炎性不育症的中药制剂。具有疗效确切、安全方便、无毒副作用、价格低廉的特点。
Description
技术领域
本发明涉及治疗附睾炎性不育症的中药制剂，是治疗附睾炎性不育症以中草药为原料的中药制剂。属于中药领域。
背景技术
附睾炎是指非特异性细菌引起的局部感染，其致病菌以大肠杆菌、葡萄球菌多见，链球菌次之，常累及睾丸。据Melekos和Asbach报道(1987年)一组附睾炎病例的细菌学资料表明，40岁以上的患者56％的致菌为沙眼衣原体，而普通的泌尿科感染占22％；40岁以上的患者沙眼衣原体感染仅18％，而泌尿道细菌感染占68％。本病临床分急性附睾炎和慢性附睾炎两类。急性附睾炎发生于急性细菌及衣原体的感染。慢性附睾炎多继发于急性期的失治误治，或与慢性前列腺炎同时存在。发病年龄以青、中年多见。可单侧或双侧同时发病，双侧发病者因附睾管腔的闭塞，可造成继发性不育症。本病属于中医“子痈”的范畴。中医学认为，附睾炎多因外感寒湿，阻塞脉络，肝经气滞；或感受湿热之邪，蕴结下焦，肝失疏泄；或久病不愈，气滞血瘀而形成。中医在临床上分为虚寒夹湿，湿热下注，气血凝滞等症型辨证治疗，取得很好效果。发明一种既安全又有效的中药制剂，具有重大意义。
发明内容
本发明是在传统的中医辨证治疗的基础上结合现代最新科研成果研制而成的。本发明的目的是提供治疗附睾炎性不育症的中药制剂。具有疗效确切、安全方便、无毒副作用、价格低廉的特点。
本发明是由下述重量配比的原料制成的：
橘核1.5～6份 荔枝核1.5～6份 桃仁1.0～4份
红花1.0～4份 夏枯草1.0～4份 厚朴1.0～4份
昆布1.0～4份 生黄芪1.0～4份 海藻1.0～4份
王不留行0.1～2份 小茴香0.1～2份 柴胡0.1～2份。
本发明的优选配方各原料的重量配比是：
橘核2.5～3.5份 荔枝核2.5～3.5份 桃仁1.5～2.5份
红花1.5～2.5份 夏枯草1.5～2.5份 厚朴1.5～2.5份
昆布1.5～2.5份 生黄芪1.5～2.5份 海藻1.5～2.5份
王不留行0.5～1.5份 小茴香0.5～1.5份 柴胡0.5～1.5份。
本发明的最佳配方各原料的重量配比是：
橘核3份 荔枝核3份 桃仁2份
红花2份 夏枯草2份 厚朴2份
昆布2份 生黄芪2份 海藻2份
王不留行1份 小茴香1份 柴胡1份。
本发明中的药物机理如下：
橘核 药性 苦，平。归肝、肾经。具有理气，散结，止痛的功效。可治疗疝气，睾丸肿痛，乳痈，腰痛等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第3745页)。
荔枝核 药性 甘、微苦，温。归肝、肾、胃经。具有理气止痛，祛寒散滞的功效。可治疗疝气痛，睾丸肿痛，胃脘痛，痛经及产后腹痛等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第2196页)
桃仁 药性 苦、甘，小毒。归心、肝、大肠经。具有活血祛瘀，润肠通便的功效。可治疗痛经，血滞经闭，产后瘀滞腹痛，癥瘕结块，跌打损伤，瘀血肿痛，肺痈，肠痈，肠燥便秘等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第2542页)。
红花药 性 辛，温。归心、肝经。具有活血通经，祛瘀止痛的功效。可治疗血瘀经闭，痛经，产后瘀阻腹痛，胸痹心痛，癥瘕结聚，跌打损伤，关节疼痛，中风偏瘫，斑疹等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第2763页)。
夏枯草 药性 苦、辛，寒。归肝、胆经。具有清肝明目，散结解毒的功效。可治疗目赤羞明，目珠疼痛，头痛眩晕，耳鸣，瘰疬瘿瘤，乳痈痄腮，痈疖肿毒，急、慢性肝炎，高血压病等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第2562页)。
厚朴 药性 苦、辛，温。归胃、大肠经。具有行气导滞，燥湿，降逆平喘的功效。可治疗食积气滞，腹胀便秘，湿阻中焦，脘痞吐泻，痰壅气逆，胸满喘咳等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第2284页)。
昆布 药性 咸，寒。归肝、胃、肾经。具有软坚化痰，利水消肿的功效。可治疗瘿瘤、瘰疠，噎膈，脚气水肿等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第1887页)。
生黄芪 药性 甘、温。归肺、脾经。具有益气升阳，固表止汗，利水消肿，托毒生肌的功效。可治疗一切气虚血亏之证，如脾虚泄泻，肺虚咳嗽，脱肛，子宫下垂，自汗，盗汗，水肿，血痹，痈疽难溃或久溃不敛等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第2813页)。
海藻 药性 咸，寒。归肝、胃、肾经。具有消痰软坚，利水退肿的功效。可治疗瘿瘤，瘰疬，脚气浮肿等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第2737页)。
王不留行 药性 苦，平。归肝、胃经。具有活血通经，下乳消痈的功效。可治疗妇女经行腹痛，经闭，乳汁不通，乳痈，痈肿等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第426页)。
小茴香 药性辛，温。归肝、肾、膀胱、胃经。具有温肾暖肝，行气止痛，和胃的功效。可治疗寒疝腹痛，睾丸偏坠，脘腹冷痛，食少吐泻，胁痛，肾虚腰痛，痛经等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版 第348页)。
柴胡 性味苦、微寒。归肝、胆经。具有和解表里、疏肝、升阳的功效。可治疗寒热往来、胸满胁痛、耳聋、头痛目眩、疟疾、下痢脱肛、月经不调、子宫下垂、感冒、上呼吸道感染、肝炎、胆囊炎等。(季宇彬主编《抗癌中药药理与应用》黑龙江科学技术出版社1999年版 第1004页)。
本发明遵循中医“君臣佐使”的组方原则，用橘核和荔枝核为君药，用桃仁、红花、夏枯草、厚朴、昆布、生黄芪和海藻为臣药；用王不留行、小茴香和柴胡为佐使药。诸药相合，共具益气散寒，理气活络的功效。治疗附睾炎性不育症具有疗效确切，无毒副作用，服用方便，价格低廉的特点。
本发明药物临床使用结果表明，有如下优点：
1、本发明选用的中草药各组份符合中华人民共和国药品管理法的规定，利用各味中药的综合作用治疗附睾炎性不育症，对人体无毒无害。经动物急、慢性毒性实验表明被实验的动物未见任何毒性反应，其主要脏器也无明显的改变，药物安全可靠。
2、本发明药中富含蛋白质，葡萄糖，葡萄糖醛酸，挥发油，果胶，果糖，有机酸，卵磷脂，维生素，氨基酸，还含皂甙，植物甾醇和钙等多种微量元素，利于人体吸收，增强体质。
3、本发明不仅可有效的治疗附睾炎性不育症，对附睾炎性不育症的预防也有很好的作用，治疗附睾炎性不育症具有疗效确切，无毒副作用，服用方便，价格低廉的特点。
为表明本发明药物对治疗附睾炎性不育症的治疗效果，经临床试验结果如下；治疗附睾炎性不育症患者18例。服用实施例汤剂，每次1袋，一日二至三次，饭前半小时服用。三个月为一个疗程，连续服用三个疗程观察疗效。痊愈9例占50％，好转7例占38.89％，未愈2例占11.11％，总有效率达88.89％。经三个疗程治疗后，病人无任何不良反应，三大常规化验及肝肾功能检测未发现异常。
具体实施方式
实施例 汤剂 按下述重量称取原料：
橘核3份 荔枝核3份 桃仁2份
红花2份 夏枯草2份 厚朴2份
昆布2份 生黄芪2份 海藻2份
王不留行1份 小茴香1份 柴胡1份。
制备方法是取上述原料洗净去杂，晾干，粉碎成颗粒，加水浸泡1小时，置多功能提取罐中加水煎煮二次，第一次加总药材10倍量的水，煎煮1.5～2小时，取煎液，滤过。第二次加总药材7倍量的水，煎煮1～1.2小时，取两次煎液，滤过，热封袋中，105℃高温灭菌，包装即得。本发明制成的治疗附睾炎性不育症的汤剂为塑封袋装，每袋210ml，口服，一次一袋，每日二至三次。三个月为一个疗程。
Claims (3)
1、治疗附睾炎性不育症的中药制剂，其特征在于它是由下述重量配比的原料制成的：
橘核 1.5～6份 荔枝核 1.5～6份 桃仁 1.0～4份
红花 1.0～4份 夏枯草 1.0～4份 厚朴 1.0～4份
昆布 1.0～4份 生黄芪 1.0～4份 海藻 1.0～4份
王不留行 0.1～2份 小茴香 0.1～2份 柴胡 0.1～2份。
2、根据权利要求1所述的治疗附睾炎性不育症的中药制剂，其中各原料的重量配比是：
橘核 2.5～3.5份 荔枝核 2.5～3.5份 桃仁 1.5～2.5份
红花 1.5～2.5份 夏枯草 1.5～2.5份 厚朴 1.5～2.5份
昆布 1.5～2.5份 生黄芪 1.5～2.5份 海藻 1.5～2.5份
王不留行 0.5～1.5份 小茴香 0.5～1.5份 柴胡 0.5～1.5份。
3、根据权利要求1所述的治疗附睾炎性不育症的中药制剂，其中各原料的重量配比是：
橘核 3份 荔枝核 3份 桃仁 2份
红花 2份 夏枯草 2份 厚朴 2份
昆布 2份 生黄芪 2份 海藻 2份
王不留行 1份 小茴香 1份 柴胡 1份。
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656123A (zh) * | 2013-12-17 | 2014-03-26 | 青岛中科菲力工程技术研发有限公司 | 一种治疗附睾炎的中药组合物 |
| CN105250742A (zh) * | 2015-08-31 | 2016-01-20 | 菏泽海诺知识产权服务有限公司 | 一种用于治疗慢性附睾炎的中药汤剂 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103656123A (zh) * | 2013-12-17 | 2014-03-26 | 青岛中科菲力工程技术研发有限公司 | 一种治疗附睾炎的中药组合物 |
| CN105250742A (zh) * | 2015-08-31 | 2016-01-20 | 菏泽海诺知识产权服务有限公司 | 一种用于治疗慢性附睾炎的中药汤剂 |
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