CN101020047B - A kind of health food containing calcium fortifier - Google Patents
A kind of health food containing calcium fortifier Download PDFInfo
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- CN101020047B CN101020047B CN200710027066XA CN200710027066A CN101020047B CN 101020047 B CN101020047 B CN 101020047B CN 200710027066X A CN200710027066X A CN 200710027066XA CN 200710027066 A CN200710027066 A CN 200710027066A CN 101020047 B CN101020047 B CN 101020047B
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- calcium
- vitamin
- health food
- nattokinase
- natto
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 29
- 235000013402 health food Nutrition 0.000 title claims abstract description 17
- 229940086319 nattokinase Drugs 0.000 claims abstract description 29
- 108010073682 nattokinase Proteins 0.000 claims abstract description 28
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- 235000005282 vitamin D3 Nutrition 0.000 claims abstract description 10
- 239000011647 vitamin D3 Substances 0.000 claims abstract description 10
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims abstract description 10
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- 230000000694 effects Effects 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 14
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- PFRQBZFETXBLTP-RCIYGOBDSA-N 2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-RCIYGOBDSA-N 0.000 description 2
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- 230000032683 aging Effects 0.000 description 2
- 150000001669 calcium Chemical class 0.000 description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 2
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- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 2
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- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
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- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
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- 235000012716 cod liver oil Nutrition 0.000 description 1
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- 235000013345 egg yolk Nutrition 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention discloses one kind of health food containing calcium reinforcing agent. The health food connects natto kinase or fermented soybean streptokinase in 100-5000 U/g and calcium reinforcing agent in 40-80 wt%. The health food of the present invention has the raised health effects of promoting calcium absorption with vitamin D3, promoting the chelating between bone and calcium with vitamin K2, lowering blood sugar, blood fat and blood pressure, preventing thrombus, etc. The present invention is suitable for all people, especially middle-aged people and old people.
Description
Technical field
The present invention relates to a kind of health food, specifically, relate to and a kind ofly have the antithrombotic effect and prevent the osteoporotic health food that contains Creta Preparata.
Background technology
Along with human sciences's development of technology, the human life-span is prolonged, and the absolute quantity of middle-aged and elderly people and relative populations are all in sustainable growth, and the mankind progress into aging society.Cardiovascular disease and osteoporosis are two kinds of main common and multiple diseases of the health and lives of serious harm middle-aged and elderly people.Now, cardiovascular disease patient's mortality rate comes first of human mortality rate, and according to estimates, there are about 1,500 ten thousand people of cardiovascular patient in the whole world, has more than 100 ten thousand people to die from cardiovascular disease every year in China.
The another kind of disease that influences the middle-aged and elderly people Health and Living quality of aging society is an osteoporosis.About 200,000,000 people in the whole world suffer from osteoporosis at present, and its sickness rate has leapt to commonly encountered diseases, frequently-occurring disease the 7th.Present Chinese patients with osteoporosis has surpassed 9,000 ten thousand people, causes millions of people's fracture.Osteoporosis is a kind ofly to subtract with gradual osseous tissue that to lose be the disease of feature, can cause bone crisp, increases the danger of fracture.Along with the increase at age, people osteoporosis can occur inevitably.Prevention and treatment how to replenish the calcium, to prevent calcium are lost.
Natto is a kind of popular fermented soybean goods that are subjected to deeply in Japan, and is edible historical in existing nearly 2000 of Japan, among the peoplely also natto used as medicine." present dynasty food mirror " be record just: natto is not only nutritious, and has preventing cold, eliminates effects such as shoulder is ached, improved liver function, treatment tuberculosis syndrome, angular cheilitis, suffers from diarrhoea and sobers up, beauty treatment.1987, Japan must see and finds a kind of protease-nattokinase with fibrinolytic in people's natto such as the professor of foreign firm.Nattokinase derives from food, is a kind of safe, cheap and orally active enzyme preparation.Studies show that oral nattokinase preparation, not only can activate the plasmin activity, also can directly dissolve fibrin, its cellulolytic activity is about 4 times of plasmin, its cellulolytic activity continuous action time in blood reached more than 4～12 hours, was better than urokinase.Studies show that in recent years, natto has unique effect for prophylaxis of hypertension (Hypertention), hypercholesterolemia (Hypercholesteromia), arteriolonecrosis diseases such as (Arteriolosclerosis).
Experiment showed, that the high calcium absorption person incidence rate of fracturing obviously reduces.The skeletal diseases of not only we being known such as osteoporosis of replenishing the calcium have preventive and therapeutic effect, and all influential to each system of whole body.Replenishing the calcium can blood sugar lowering, blood fat reducing, blood pressure lowering, fat-reducing, prevention urinary system calculus, resist lead loss wound etc.From the angle of nutrition, the enough absorption calcium of middle-aged and elderly people is the important measures of prevention of osteoporosis.In people's the diet structure, the source of general calcium mainly contains: milk, beans, fish and shrimp, Semen arachidis hypogaeae, Thallus Laminariae (Thallus Eckloniae), Auricularia, Lentinus Edodes, sesame paste and many green vegetables etc.Animal food calcium easily absorbs than plant food calcium, and the phytic acid in the plant food (as beans, fruit and vegerable etc.), the oxalic acid in the vegetable etc. can form insoluble calcium phosphate with calcium, reduce the absorption of calcium.At present, taking in the calcium recommended amounts every day of the U.S., Canadian two countries is 1000mg, and China, Australia are 800mg.But whole nation investigation in 2002 shows that China resident dietary calcium every day intake is 390.6mg, accounts for 48.8% of recommended amounts.If be deficient in vitamin D, also can influence the absorption of calcium.The D that supports one's family can regulate alcium and phosphor metabolization, promotes the absorption of small intestinal to calcium, and calcium is deposited in the skeleton.Therefore in diet structure, should increase animality milk or the shared ratio of milk product, increase the intake of calcium, available egg yolk, animal livers and cod-liver oil etc. replenish the food intake of vitamin D simultaneously, and also available ca condensed food or calcium preparation and Vitamin D preparation directly replenish needed by human body.
The Boot doctor in United States Department of Agriculture (USDA) human nutrition research center finds that the K that is deficient in vitamin may be a key factor that causes the senile fracture, thereby raising vitamin K intake can effectively prevent osteoporosis and fracture.Vitamin k is the coenzyme of glutamic acid gamma-carboxylase, and the γ position that can participate in glutamic acid in the Bone Gla protein is carboxylated, thereby promotes the bone mineral content deposition, and finally promotes bone formation.Japan has approved that vitamin K is the osteoporosis therapy medicine as far back as nineteen ninety-five.The FDA trophic level of U.S.'s utilization at present is decided to be male's 80 micrograms and women's 65 micrograms with the daily requirement amount of vitamin K.If consider the health of skeleton, this is a certain amount of to improve 2 to 3 times possibly, considers that from this point the vitamin K intake of most middle-aged and elderly people is wretched insufficiency also.But Bacillus natto equal metabolism in the fermented soybean process or in animal intestinal produces vitamin k.(γ-PGA) can be in the presence of vitamin k 2 and Ca for the γ-polyglutamic acid that produces in the Bacillus natto sweat
2+Coupling improves the absorption of human body to calcium.
Summary of the invention
The object of the present invention is to provide a kind of can the prevention or the health food that contains Creta Preparata of auxiliary treatment middle-aged and elderly people cardiovascular disease or osteoporosis.
In order to achieve the above object, the health food that contains Creta Preparata of the present invention contains nattokinase or Douchi Fibrinolytic Enzyme DFE and Creta Preparata, the addition of nattokinase or Douchi Fibrinolytic Enzyme DFE is that 100～5000U is added in every restraint agent, and Creta Preparata is 40～80% of a gross weight.
In the above-mentioned health food that contains Creta Preparata, also contain the food adjuvant, the food adjuvant can be used for promoting the absorption of calcium.
In the above-mentioned health food that contains Creta Preparata, described nattokinase can be for the natto dry powder that contains nattokinase, contain the Bacillus natto tunning lyophilized powder of nattokinase or contain the natto extract of nattokinase; Described Douchi Fibrinolytic Enzyme DFE can be the Semen Sojae Preparatum dry powder that contains Douchi Fibrinolytic Enzyme DFE, the Semen Sojae Preparatum bacterium tunning lyophilized powder that contains Douchi Fibrinolytic Enzyme DFE or the touchi extract that contains Douchi Fibrinolytic Enzyme DFE.
In the above-mentioned health food that contains Creta Preparata, described Creta Preparata is one or more the mixture in calcium carbonate, calcium acetate, calcium citrate, the activated calcium.
In the above-mentioned health food that contains Creta Preparata, described food adjuvant is one or both the mixture in K vitamin, the D vitamin.K vitamin preferred vitamin K2; D vitamin preferred vitamin D3.
In the above-mentioned health food that contains Creta Preparata, described health food can be made into tablet or powder or the like regular dosage form.
Compared with prior art, the present invention has following beneficial effect:
The health food that contains Creta Preparata of the present invention improves health-care effect by cooperatively interacting and acting between multicomponent, can promote the absorption of calcium as (1) vitamin D3; (2) Menaquinone K6 can promote sclerotin and the effect of calcium sequestration; (3) effective absorption of calcium can blood sugar lowering, blood fat reducing, blood pressure lowering and is prevented the generation of thrombotic disease, with the potentiation that has of nattokinase and Douchi Fibrinolytic Enzyme DFE.Said preparation all has health-care effect for the crowd of various age levels, especially has health-care effect preferably aspect middle-aged and elderly people health status and quality of life improving.
Description of drawings
Fig. 1 is the influence of treatment of different temperature to the nattokinase preparation;
Fig. 2 is the influences of different holding conditions to the nattokinase preparation;
Fig. 3 measures remnant enzyme activity figure to the flat band method of nattokinase preparation under the different holding conditions (A is-18 ℃/30 days, and B is-18 ℃/180 days, and C is 4 ℃/30 big, and D is 4 ℃/180 days, and E is room temperature/30 day, and F is room temperature/180 day.)
The specific embodiment
Embodiment 1 selects fresh natto for use, pulverizes after-50 ℃ of following cryogenic vacuum lyophilizations, measures natto kinase activity and Bacillus natto number of viable behind 80 mesh sieves excessively; Get natto powder 10～40g, the nattokinase gross activity is reached more than the 20000U, calcium carbonate 60g, carboxymethyl cellulose 10g, white sugar 10g, vitamin D3 10000U, fully behind the mix homogeneously, compacting is in flakes.
Embodiment 2 selects fresh natto for use, pulverizes after-50 ℃ of following cryogenic vacuum lyophilizations, measures natto kinase activity and Bacillus natto number of viable behind 80 mesh sieves excessively; Get natto powder 5～20g, the nattokinase gross activity is reached more than the 13000U, calcium citrate 105g, vitamin D3 10000U, Menaquinone K6 2000ug fully behind the mix homogeneously, records capsule.
Embodiment 3 adds the skimmed milk of 20% (w/v) in bacillus natto to ferment liquid, pulverize after-50 ℃ of following cryogenic vacuum lyophilizations, measures natto kinase activity and Bacillus natto number of viable behind 80 mesh sieves excessively; Get natto powder 2～10g, the nattokinase gross activity is reached more than the 15000U, calcium acetate 100g, carboxymethyl cellulose 9g, white sugar 9g, vitamin D3 10000U, fully behind the mix homogeneously, compacting is in flakes.
Embodiment 4 gets nattokinase 200000U, calcium carbonate 100g, and starch 20g, vitamin D3 10000U fully behind the mix homogeneously, records capsule.
Embodiment 5 gets douchi fibrinolytic enzyme 300000U, activated calcium 100g, and starch 20g, vitamin D3 10000U fully behind the mix homogeneously, records capsule.
Activity experiment 1: in bacillus natto to ferment liquid, add the skimmed milk of 20% (w/v), pulverize after-50 ℃ of following cryogenic vacuum lyophilizations, measure natto kinase activity and viable count behind 80 mesh sieves excessively; Getting lyophilized powder and calcium carbonate in proportion makes the 100g mixture contain nattokinase 250000U, Ca
2+30000mg, vitamin D3 10000U and amount of starch, fully mix homogeneously is standby.After getting mixed dust formulation and press 1:5 and dilute with phosphate buffer (pH7.8), respectively behind processing 5,10 and 20min under 30 ℃, 50 ℃, 70 ℃, 90 ℃, adopt the fiber flat band method to measure the mixture natto kinase activity, repeat 3 experiments, to understand the influence of different temperatures to the preparation natto kinase activity.Experiment shows that preparation is insensitive to the Temperature Treatment below 50 ℃, but temperature rises to 70 ℃, and natto kinase activity significantly reduces, and can not measure enzymatic activity (referring to accompanying drawing 1) in the time of 90 ℃.
Activity experiment 2: the mix preparation that adopts experiment 1 to make, with being positioned over (about 4 ℃) and refrigerating chamber between room temperature, refrigerator cold-storage (-18 ℃ approximately) after the packing of ground reagent bottle respectively, timing sampling adopts the fiber flat band method to measure the nattokinase remnant enzyme activity, repeats 3 tests.The result shows, preserves after 180 days, and the sample remnant enzyme activity under the room temperature still has nearly 80% residual enzyme activity, and the sample enzyme of preserving in refrigerator is lived and reduced not significantly (referring to accompanying drawing 2,3).
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| CN101570747A (en) * | 2008-04-28 | 2009-11-04 | 郑党恩 | Super-active nattokinase (NK) powder and preparation method thereof |
| CN109769947A (en) * | 2017-11-15 | 2019-05-21 | 内蒙古伊利实业集团股份有限公司 | A kind of improvement bone health functional composition and products thereof and application |
| CN108175096A (en) * | 2018-02-26 | 2018-06-19 | 广东正当年生物科技有限公司 | A kind of strong bone food |
| CN118078876A (en) * | 2024-03-13 | 2024-05-28 | 武汉真福创新生物制药有限公司 | Composition, preparation method and application thereof |
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Assignee: Shenzhen agriculture and animal husbandry industry Co., Ltd. Assignor: South China Agricultural University Contract record no.: 2011440000937 Denomination of invention: Health food containing calcium reinforcing agent Granted publication date: 20110622 License type: Exclusive License Open date: 20070822 Record date: 20110811 |
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