CN100394937C - Medicine for preventing and treating cardiac and cerebral vascular diseases - Google Patents
Medicine for preventing and treating cardiac and cerebral vascular diseases Download PDFInfo
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Abstract
The present invention discloses a medicament for preventing and treating cardiovascular/cerebrovascular diseases. The medicament is prepared from the following natural crude medicines of the portion by weight: 3 to 5 portions of damnacanthus, 3 to 5 portions of caragana sinica, 5 to 8 portions of spanishneedles herbs, 3 to 5 portions of scutellaria roots, 2 to 3 portions of piper hancei maxim and 15 to 30 portions of fructus jujubae. The medicament has the functions for suppressing thrombosis, increasing cerebral blood flow, dissolving thrombus, suppressing platelet aggregation, reducing the area of myocardial infarction, reducing the total peripheral resistance of blood vessels, increasing the coronary blood flow of hearts. The present invention can prevent or treat diseases comprising chest distress, angina pectoris, insomnia, headaches, hemiplegia induced by cardiovascular/cerebrovascular thrombosis, quadriplegia, dribbling, monoanesthesia, dermatorrhexis, sciatica, etc.The medicament has a unique curative effect on the cardiovascular/cerebrovascular diseases comprising apoplexia, coronary heart diseases, cerebral hemorrhage, cerebral thrombosis, etc. The medicament is a preparation prepared from unmixed traditional Chinese medicines, and has the advantages of reasonable prescription, low cost, easy processing and obvious clinic curative effect.
Description
Skill this area:
The present invention relates to a kind of is the medicine of raw material with the natural Chinese medicine, particularly relates to the medicine of a kind of prevention or treatment cardiovascular and cerebrovascular disease, belongs to medical technical field.
Background skill basis:
Cardiovascular and cerebrovascular disease such as coronary heart disease, cerebral thrombosis, hypertension, cerebral infarction etc. are the commonly encountered diseases in the world today, frequently-occurring disease, the sickness rate height, the disability rate height, the mortality rate height, also can cause the heart, brain, the damage of organs such as kidney, cause as brain and die suddenly, heart failure, diseases such as renal failure, it is the disease of a kind of serious harm human health and life, domestic and social life is exerted a certain influence, " the first killer " of the harm humans of being known as life, according to clinical report, sickness rate in recent years has and increases trend year by year, and in, young patient constantly increases.Therefore the medicine of developmental research prevention or treatment cardiovascular and cerebrovascular disease becomes the focus of people's research, and many scholars are in treatment and the prevention of exploring cardiovascular and cerebrovascular disease both at home and abroad.Yet clinical practice shows that the simple western medicine treatment is only cured the symptoms, not the disease, and especially side effects of pharmaceutical drugs make the patient be difficult to accept and take for a long time.Contemporary mankind's the hope that goes back to nature is strong day by day, generally wish the Chinese herb on the prevention or the treatment of natural nuisance-free, thereby for the development of Chinese medicine provides excellent opportunity, be " DANHONG ZHUSHEYE ", " the DANHONG drip liquid " that raw material is made for example by Radix Salviae Miltiorrhizae, two kinds of Chinese herbal medicine of Flos Carthami, rapid, the determined curative effect of onset aspect acute cardiovascular and cerebrovascular disease rescue, be widely used clinically, recorded in National Drug Administration's " national standard for traditional Chinese medicines compilation ".But, need the long-term prescription treatment, thereby the medication of drug administration by injection has been subjected to certain restriction in the use because cardiovascular and cerebrovascular disease is a chronic disease.Therefore press for clinically that steady quality, determined curative effect, dose are little, the prevention of taking convenience or the oral drug preparation of treatment cardiovascular and cerebrovascular disease.
In the upsurge of human " back to nature ", Chinese medicine is little with its good effect, side effect, aboundresources and extremely people's favor, increasing clinical report shows, Chinese medicine is having a good application prospect aspect prevention or the treatment cardiovascular and cerebrovascular disease, and obtain patient's approval day by day, the Chinese patent medicine of treatment cardiovascular and cerebrovascular disease many based on blood fat reducing, cholesterol reducing, blood vessel dilating, adjusting heart joint rate, improve cardiac function.In recent years, people have strengthened the research of Chinese herb on the prevention or treatment cardiovascular and cerebrovascular disease, mainly be from traditional prescription, to screen, obtained certain achievement, (application number is 97105867.9 as Chinese patent CN1200278A, denomination of invention is " a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease ") in a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease is disclosed, its prescription consists of: Herba Taxilli 6~10%, Caulis Spatholobi 6~10%, Pheretima 3~7%, Radix Salviae Miltiorrhizae 8~12%, Flos Carthami 6~10%, the Radix Astragali 6~10%, Herba Cynomorii 8~12%, Rhizoma Chuanxiong 8~12%, Radix Cyathulae 8~12%, Rhizoma Arisaematis 3~7%, Ramulus Uncariae Cum Uncis 2~6%, Bulbus Allii Macrostemonis 3~7%, Radix Rehmanniae 2~6%, Semen Strychni 3~7%.Among the Chinese patent CN1679831A (application number is 200510041653.5, denomination of invention be " a kind of oral drugs and method for making thereof for the treatment of cardiovascular and cerebrovascular disease ") a kind of medicine for the treatment of cardiovascular and cerebrovascular disease is disclosed and for example, it is to be raw material with Radix Salviae Miltiorrhizae, Flos Carthami two flavor Chinese herbal medicine, adopt low-concentration ethanol to ooze rumble method or water retting method technology respectively and extract water soluble ingredient in the two flavor Chinese medicines, again through formulated oral Chinese medicine preparation.From above these aspects as can be seen: there is very abundant pools of traditional Chinese medicine in China, has a lot of very effective Chinese medicinal formulaes, awaits further excavating and utilizing, and benefits the people.
Summary of the invention:
The object of the present invention is to provide the medicine of prevention remarkable, with low cost of a kind of advantages of simple of filling a prescription, clinical effectiveness or treatment cardiovascular and cerebrovascular disease.
The objective of the invention is to be achieved through the following technical solutions:
The medicine of a kind of prevention or treatment cardiovascular and cerebrovascular disease is made 3~5 parts of Herba Damnacanthi, 3~5 parts of caraganas, 5~8 parts of Herba Bidentis Bipinnatae, 3~5 parts of Radix Scutellariaes, 2~3 parts of Caulis et Folium piperiss, 15~30 parts in Fructus Jujubae by the following natural material medicine that with the weight portion is unit.
The medicine of described prevention or treatment cardiovascular and cerebrovascular disease is made 4 parts of Herba Damnacanthi, 3 parts of caraganas, 7 parts of Herba Bidentis Bipinnatae, 4 parts of Radix Scutellariaes, 2 parts of Caulis et Folium piperiss, 20 parts in Fructus Jujubae by the following natural material medicine that with the weight portion is unit.
Take by weighing each component of described weight portion, after grinding together, cross 100~120 mesh sieves,, make required pharmaceutical dosage form by medically conventional processing method.
Described pharmaceutical dosage form is a powder, or is tablet, or is pill, or is granule, or is capsule, or is injection.
Positive beneficial effect of the present invention is:
1. the medicine of prevention of the present invention or treatment cardiovascular and cerebrovascular disease, based on motherland's Chinese medicine and pharmacy theory, in conjunction with clinical practice for many years, from motherland's medicine treasure-house, filter out the medicine that has dredging vascellum, regulates nerve, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, residence is attacked in mending, attacking and just not to be hindered, to mend and do not stop up, and can obviously improve the immunity of human body.In this medicine, Herba Damnacanthi: flat, the sweet in the mouth of property, but expelling wind and removing dampness, dissipating blood stasis for subsidence of swelling; Caragana: warm in nature, sweet in the mouth can expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, preventing phlegm from forming and stopping coughing; Herba Bidentis Bipinnatae: be the herb of feverfew Herba Bidentis Bipinnatae, herb contains main components such as alkaloid, tannin, Saponin and flavonoid glycoside, bitter in the mouth, flat, nontoxic, go into lung, stomach, large intestine, gallbladder four warps, but heat clearing away, detoxifcation, dissipating blood stasis, detumescence, expelling wind and activating blood circulation, prevent the generation of cardiovascular and cerebrovascular diseases such as thrombosis, prevention of arterial sclerosis, cerebral thrombosis, coronary heart disease effectively, improve cardiac function; The Radix Astragali: warm in nature, sweet in the mouth return spleen, lung, but tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, expelling pus and toxin by strengthening QI, inducing diuresis to remove edema is used for diseases such as the deficiency of vital energy is weak, chronic diarrhea proctoptosis, open sore part disunion of a specified duration; Caulis et Folium piperis: property is flat, acrid in the mouth, acid, but expelling wind and removing dampness, activating collaterals to relieve pain; Fructus Jujubae: property is sweet, warm, contains materials such as protein, fat, saccharide, organic acid and calcium, phosphorus, ferrum, carotene and vitamin B, C, P, and Fructus Jujubae is listed in five fruits in Compendium of Material Medica, its medical value is paid attention to by people since ancient times, the essentials of Matea Medica cloud: " spleen soil is grown in the Fructus Jujubae invigorating the spleen and replenishing QI; profit cardiopulmonary; transfer Rong Wei, slow cloudy blood, born fluid; improving healthy complexion; logical nine orifices, helps 12 warps and hundred medicines." Fructus Jujubae can and hundred medicines, help the twelve regular channels, be the good medicine of regulating the spleen and stomach QI invigorating, have that foster spleen stomach function regulating, supplementing QI for promoting the production of body fluid, tonify deficiency are moisturized, blood vessel dilating, enhancing myocardial contraction, improve the effect of myocardial nutrition.More than this Six-element medicine lump together use, but dredging vascellum, regulate neural, play blood circulation promoting and blood stasis dispelling altogether, the effect of heat-clearing and toxic substances removing, have the cerebrovascular permeability of alleviating and brain water content, suppress thrombosis, obvious cerebral blood flow increasing amount, thrombus, anticoagulant, reduce myocardial infarction area, reduce the blood vessel total peripheral resistance, increase the effect of heart coronary flow, can prevent or treat uncomfortable in chest, angina pectoris, insomnia, headache, the hemiplegia that the cardiovascular and cerebrovascular vessel thromboembolism causes, extremity are refused to budge, sialorrhea, mono-anesthesia, Dermatorrhexis, diseases such as sciatica are to cardiovascular and cerebrovascular disease such as apoplexy, coronary heart disease, cerebral hemorrhage, diseases such as cerebral thrombosis have unique curative effect.
2. the medicine of prevention of the present invention or treatment cardiovascular and cerebrovascular disease is Chinese medicine preparation, need not decoct, can carry, and taking convenience, general patients with mild need not be in hospital, and can reduce patient's spending significantly, reduces prevention or medical expense.
3. the medicine of prevention of the present invention or treatment cardiovascular and cerebrovascular disease, prescription is reasonable, and cost is low, and processing is simple, and clinical efficacy is obvious, is applicable to the patient of all kinds of decentraction cerebrovascular disease, is subjected to the favorable comment of patient and family numbers of patients deeply.
4. the medicine of prevention of the present invention or treatment cardiovascular and cerebrovascular disease, its injection can be applied to the first aid aspect, has obtained certain effect clinically, is worthy to be popularized.
5. the medicine of prevention of the present invention or treatment cardiovascular and cerebrovascular disease, effect is also fine aspect treatment epistaxis (claiming epistaxis again).Epistaxis is epistaxis again, its cause of disease has two classes, one class is a constitutional cause, as hypertension, disease in the blood system, avitaminosis etc., hypertension generally is more common in the adult, and the epistaxis that has hypertension history, hypertension to cause mostly occurs in the nasal cavity rear end more, therefore easily from flowing out in the mouth.In the time of epistaxis that disease in the blood system causes, tending to has petechia, ecchymosis on skin and oral mucosa, or situation of haemophilia etc. is arranged; Another kind of is exactly the local cause of nasal cavity: wound (comprising the dry angiorrhexis that causes), tumor, specific infection disease etc.The present invention is aspect the above-mentioned epistaxis symptom of treatment, and effect is also very remarkable.
Clinical efficacy situation statistics:
1. case is selected: the hospital at inventor place accepts patient's 298 examples of national cardiovascular and cerebrovascular disease so far altogether for medical treatment from the nineties in last century, male's 239 examples wherein, women's 59 examples, male, women patient's ratio is about 4: 1, patient 104 examples of age between 20~45 years old, account for 35%, patient 164 examples of age between 45~65 years old account for 55%, patient's 30 examples of other age bracket, account for 10%, the most of patients course of disease is more than half a year.
2. Therapeutic Method: to being diagnosed as the patient of cardiovascular and cerebrovascular disease, give the drug administration of prevention of the present invention or treatment cardiovascular and cerebrovascular disease, twice on the one, one time 6~8 gram, warm boiled water, 10 days is a course of treatment, generally needs to treat 2~5 courses of treatment, and the state of an illness just can be effectively controlled and reach the purpose of healing.
3. points for attention:
Avoid suffering, peppery, greasy food and Folium Camelliae sinensis and tobacco and wine at period in a medicine.
4. curative effect judging standard:
Recovery from illness: clinical symptoms thoroughly disappears, and it is normal that cardiac function recovers, and drug withdrawal was not seen the recidivist more than 1 year;
Produce effects: clinical symptoms disappears substantially, and focus is basicly stable, observes more than half a year;
Effectively: pain and other clinical symptoms are obviously alleviated, and just can fully recover after adding inventor's auxiliary prevention of other medicines or treatment.
Invalid: clinical symptoms does not have obvious improvement.
5. prevent or therapeutic outcome:
Therapeutic outcome | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate |
Number | 157 | 109 | 28 | 4 | |
Percentage ratio | 52.68% | 36.57% | 9.39% | 1.34% | 98.65% |
By above-mentioned clinical efficacy situation statistics as can be known: medicine of the present invention has better curative effect to various types of cardiovascular and cerebrovascular diseases, treating both the principal and secondary aspects of a disease, and total effective rate reaches 98.65%.
Model case:
1. Liu, man, 83 years old, Bei Shankou town, Gongyi City people from mountains and rivers, because of cerebral thrombosis was in hospital two months in the People's Hospital, Gongyi City, the symptom left side can't be movable, general aching, the hospital admission at the inventor place of coming after tin people introduces, the drug administration of treatment cardiovascular and cerebrovascular disease of the present invention is taken in suggestion, twice, one time on the one 6 gram, warm boiled water, 10 days is a course of treatment, treat 2 courses of treatment after, cure, following up a case by regular visits to after 1 year does not have recurrence, now freedom of action such as ordinary person.
2. poplar, man, 65 years old, hilltop village, villages and small towns, west, aphasis takes place suddenly on February 16th, 99, and the right side limb activity is unfavorable, suddenly distortion of commissure after four days, stiff tongue is felt embarrassed to mention, right half body paralysis, and doctor trained in Western medicine is diagnosed as " cerebral thrombosis ", take the medicine of treatment cardiovascular and cerebrovascular disease of the present invention, twice, one time on the one 8 gram, warm boiled water, 10 days is a course of treatment, after treating 1 course of treatment, language is gradually sharp, bicker gradually just, continue to take the medicine of treatment cardiovascular and cerebrovascular disease of the present invention and fully recover after 3 courses of treatment, followed up a case by regular visits to 2 years, blood pressure stabilization, action is normal, does not have recurrence.
The hair certain, the man, 69 years old, the flat-top recluse, suffer from hypertension oneself reach 30 surplus year, be up to 240/130 millimetres of mercury, take FUFANG JIANGYA PIAN all the year round, Bezoar pill for lowering blood pressure, beniol, NAOXINTONG, XUESHUANXINMAINING, multiple anti-sclerosis vessel softening depressor such as DIAOXINXUE KANG, the hospital at inventor place goes to a doctor in March, 1998, take that blood pressure drops is 160/100 millimetres of mercury after 1 course of treatment, electrocardiogram shows normal, checks that blood pressure is reduced to 150/80 millimetres of mercury after the course of treatment of taking medicine again, electrocardiogram is normal, dizzy cardiopalmus disease disappears, and is normal so far, is almost recovered;
4. Wang, woman, 61 years old, people from Dangshan, Anhui, it is nervous to occur cardiopalmus in 2000, symptoms such as sensation of oppression over the chest with shortness of breath, after develop into chest pain, be diagnosed as hypertension by local hospital, coronary heart disease, blood pressure is 150/95 millimetres of mercury, treated with " storax pill for treating coronary heart disease ", alleviated, in JIUYUE, 2002 chest pain increases the weight of, every day 3,5 times, sometimes continue 7, can alleviate in 8 minutes, with headache feeling of fullness in the head phenomenon, the medicine of taking treatment cardiovascular and cerebrovascular disease of the present invention carries out simultaneously, twice on the one, one time 8 gram, warm boiled water, 10 days is a course of treatment, after taking 1 course of treatment, feeling of oppression and pain in the chest disappears, blood pressure 135/85 millimetres of mercury, take 2 courses of treatment again continuously after, blood pressure, it is normal that electrocardiogram recovers, blood fat is also normal, does not have recurrence so far.
5. health, the man, 60 years old, the Bei Shankou of Gongyi City town people from mountains and rivers was in hospital because of the stomach cerebral thrombosis and do not heal in two months, the normal cerebral embolism symptom that takes place in the back of leaving hospital, take a course of treatment after, recovery from illness.
6. journey, the woman, 65 years old, the Puyang people of Hebei province, the sunlight hospital admission was not healed in one month in Gongyi City, had a headache often, symptoms such as insomnia, angina cordis, take a course of treatment after, recovery from illness.
Still certain, woman, 48 years old, Bei Shankou town, Gongyi City people from mountains and rivers has hypertension history, and the epistaxis symptom takes place suddenly in June, 2005, intermittent lasting 20 days, come after listening the people the to introduce hospital admission at inventor place, suggestion is taken medicine of the present invention, twice on the one, a 3-5 gram, warm boiled water after 3 days, is cured.
The specific embodiment:
Embodiment one: the medicine of a kind of prevention or treatment cardiovascular and cerebrovascular disease, and containing with the weight portion is the following natural material medicine of unit, 3 parts of Herba Damnacanthi, 3 parts of caraganas, 5 parts of Herba Bidentis Bipinnatae, 3 parts of Radix Scutellariaes, 2 parts of Caulis et Folium piperiss, 15 parts in Fructus Jujubae takes by weighing each component of described weight portion, after grinding together, cross 100~120 mesh sieves, make required pharmaceutical dosage form, as be powder, or be tablet, or be pill, or be granule, or be capsule, or be injection.To being diagnosed as the patient of cardiovascular and cerebrovascular disease, give the drug administration of above-mentioned treatment cardiovascular and cerebrovascular disease, twice on the one, one time 6~8 gram, warm boiled water, 10 days is a course of treatment, generally need to prevent or treat 2~5 courses of treatment, the state of an illness just can be effectively controlled and reach the purpose of healing.
Patient for preventing takes said medicine, twice, one time on the one 4~6 gram, and warm boiled water, get final product 2 courses of treatment.
Above-mentioned injection dosage form also can be carried out first aid to the patient of sudden cardiovascular and cerebrovascular disease.
Said medicine also can be applicable in the treatment of epistaxis, twice, one time on the one 3~4 gram, and warm boiled water can be cured in 2~5 days.
Avoid suffering, peppery, greasy food and Folium Camelliae sinensis and tobacco and wine at period in a medicine.
Embodiment two: present embodiment medicine processing method, instructions of taking and points for attention are with embodiment one, something in common does not repeat, difference is: the medicine of a kind of prevention or treatment cardiovascular and cerebrovascular disease, containing with the weight portion is the following natural material medicine of unit, 5 parts of Herba Damnacanthi, 5 parts of caraganas, 8 parts of Herba Bidentis Bipinnatae, 5 parts of Radix Scutellariaes, 3 parts of Caulis et Folium piperiss, 30 parts in Fructus Jujubae.
Said medicine also can be applicable in the treatment of epistaxis, twice, one time on the one 3~4 gram, and warm boiled water can be cured in 2~5 days.
Embodiment three: present embodiment medicine processing method, instructions of taking and points for attention are with embodiment one, something in common does not repeat, difference is: the medicine of a kind of prevention or treatment cardiovascular and cerebrovascular disease, containing with the weight portion is the following natural material medicine of unit, 4 parts of Herba Damnacanthi, 3.5 parts of caraganas, 7 parts of Herba Bidentis Bipinnatae, 4.5 parts of Radix Scutellariaes, 2.5 parts of Caulis et Folium piperiss, 20 parts in Fructus Jujubae.
Said medicine also can be applicable in the treatment of epistaxis, twice, one time on the one 3~4 gram, and warm boiled water can be cured in 2~5 days.
Embodiment four: present embodiment medicine processing method, instructions of taking and points for attention are with embodiment one, something in common does not repeat, difference is: the medicine of a kind of prevention or treatment cardiovascular and cerebrovascular disease, containing with the weight portion is the following natural material medicine of unit, 4.5 parts of Herba Damnacanthi, 4 parts of caraganas, 6 parts of Herba Bidentis Bipinnatae, 3.5 parts of Radix Scutellariaes, 2.2 parts of Caulis et Folium piperiss, 19 parts in Fructus Jujubae.
Said medicine also can be applicable in the treatment of epistaxis, twice, one time on the one 3~4 gram, and warm boiled water can be cured in 2~5 days.
Embodiment five: present embodiment medicine processing method, instructions of taking and points for attention are with embodiment one, something in common does not repeat, difference is: the medicine of a kind of prevention or treatment cardiovascular and cerebrovascular disease, containing with the weight portion is the following natural material medicine of unit, 3.8 parts of Herba Damnacanthi, 4.2 parts of caraganas, 6.5 parts of Herba Bidentis Bipinnatae, 4.6 parts of Radix Scutellariaes, 3 parts of Caulis et Folium piperiss, 23 parts in Fructus Jujubae.
Said medicine also can be applicable in the treatment of epistaxis, twice, one time on the one 3~4 gram, and warm boiled water can be cured in 2~5 days.
Embodiment six: present embodiment medicine processing method, instructions of taking and points for attention are with embodiment one, something in common does not repeat, difference is: the medicine of a kind of prevention or treatment cardiovascular and cerebrovascular disease, containing with the weight portion is the following natural material medicine of unit, 4 parts of Herba Damnacanthi, 3 parts of caraganas, 7 parts of Herba Bidentis Bipinnatae, 4 parts of Radix Scutellariaes, 2 parts of Caulis et Folium piperiss, 20 parts in Fructus Jujubae.
Said medicine also can be applicable in the treatment of epistaxis, twice, one time on the one 3~4 gram, and warm boiled water can be cured in 2~5 days.
Claims (4)
1. a medicine that prevents or treat cardiovascular and cerebrovascular disease is characterized in that: made 3~5 parts of Herba Damnacanthi, 3~5 parts of caraganas, 5~8 parts of Herba Bidentis Bipinnatae, 3~5 parts of Radix Scutellariaes, 2~3 parts of Caulis et Folium piperiss, 15~30 parts in Fructus Jujubae by the following natural material medicine that with the weight portion is unit.
2. the medicine of prevention according to claim 1 or treatment cardiovascular and cerebrovascular disease is characterized in that: made 4 parts of Herba Damnacanthi, 3 parts of caraganas, 7 parts of Herba Bidentis Bipinnatae, 4 parts of Radix Scutellariaes, 2 parts of Caulis et Folium piperiss, 20 parts in Fructus Jujubae by the following natural material medicine that with the weight portion is unit.
3. the medicine of prevention according to claim 1 and 2 or treatment cardiovascular and cerebrovascular disease, it is characterized in that: take by weighing each component of described weight portion, after grinding together, cross 100~120 mesh sieves, by medically conventional processing method, make required pharmaceutical dosage form.
4. the medicine of prevention according to claim 3 or treatment cardiovascular and cerebrovascular disease, it is characterized in that: described pharmaceutical dosage form is a powder, or is tablet, or is pill, or is granule, or is capsule, or is injection.
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CN1091381C (en) * | 1999-11-02 | 2002-09-25 | 黄治源 | Medicine composition for curing angiocardiopathy and cerebrovascular disease and its preparation method |
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CN1091381C (en) * | 1999-11-02 | 2002-09-25 | 黄治源 | Medicine composition for curing angiocardiopathy and cerebrovascular disease and its preparation method |
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