CN100361705C - A traditional Chinese medicine composition for treating chronic atrophic gastritis - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating chronic atrophic gastritis. The composition and weight percentage of the traditional Chinese medicine composition are: 3.5%-4% of Pinellia chinensis, 18%-19% of Coptis chinensis, 18%-19% of dried ginger, 9%-9.5% of ginseng, 18%-19% of Scutellaria baicalensis, thick Park 9%-9.5%, frankincense 3.5%-4%, roasted licorice 18%-19%. The medicine can be used for the treatment of chronic atrophic gastritis with mixed cold and heat. The clinical cure rate of the traditional Chinese medicine composition involved in the present invention accounts for 10%; the effective rate accounts for 33%; the effective rate accounts for 43%; and the total effective rate accounts for 87%.

Description

A traditional Chinese medicine composition for treating chronic atrophic gastritis

technical field

The invention belongs to the field of traditional Chinese medicines and relates to a traditional Chinese medicine composition for treating chronic atrophic gastritis.

Background technique

Chronic atrophic gastritis is a common digestive tract disease characterized by atrophy of gastric mucosal glands. WHO lists it as a precancerous state of gastric cancer. Currently, there is no specific drug for chronic atrophic gastritis. Commonly used traditional Chinese medicine prescriptions such as Sini Powder (from "Treatise on Febrile Diseases", contained in "Prescription Science" page 58), Sanren Decoction (from "Warm Disease Tiaobian", contained in "Prescription Science Lecture Notes" page 190), Xiangsha Liu Junzi Decoction (from "Shi Fang Ge Kuo", contained in "Fresh Diseases", page 231), Shashen Maidong Decoction (from "Febrile Diseases", contained in "Prescriptions", page 231) and other treatment principles are different , but none of them can comprehensively treat chronic atrophic gastritis.

Contents of the invention

The object of the invention is to provide a traditional Chinese medicine composition for treating chronic atrophic gastritis. The invention can effectively restrain the atrophy of the gastric mucosa, hinder its development to cancer, and has good curative effect.

A traditional Chinese medicine composition for treating chronic atrophic gastritis of the present invention is formulated according to monarch, minister, and envoy: Pinellia is the monarch drug; Coptidis Rhizome, dried ginger, and ginseng are minister drugs; Scutellaria baicalensis, Magnolia officinalis, and frankincense are adjuvant drugs Radix Glycyrrhiza is used as medicine; and the composition and weight percentage of the traditional Chinese medicine composition are: Pinellia chinensis 3.5%-4%, Coptidis 18%-19%, dried ginger 18%-19%, ginseng 9%-9.5%, Scutellaria baicalensis 18%-19%, Magnolia officinalis 9%-9.5%, frankincense 3.5%-4%, roasted licorice 18%-19%.

A traditional Chinese medicine composition for treating chronic atrophic gastritis of the present invention is based on the theory of traditional Chinese medicine, according to the prescription of monarch, minister, adjuvant and envoy: Pinellia is the monarch drug; Coptis chinensis, dried ginger and ginseng are minister drugs; Pu and frankincense are adjuvant medicines; roasted licorice is an envoy;

Below, according to the theory of traditional Chinese medicine, the compatible components of a kind of Chinese medicine composition for treating chronic atrophic gastritis of the present invention are further described:

Pinellia is the king medicine. Give play to its invigorating the spleen and harmonizing the stomach, dissipating stagnation and eliminating swelling, lowering the adverse effect of removing swelling and relieving pain, and mainly treating weakness of the spleen and stomach, cold and heat mixed spleen syndrome; Coptis chinensis, assisting the monarch drug in dispelling dampness and regulating the middle, exerting its heat-clearing and damp-drying, regulating the stomach and thickening the intestines, strengthening the Yin and stop dysentery; Dried ginger, assisting the monarch drug, exerts its effect of warming and tonifying the spleen and stomach, dispelling cold and reducing adverse reactions; Magnolia officinalis, assists pinellia and dried ginger to warm the middle and reduce adverse events, exerts its function of promoting qi, drying dampness, eliminating swelling and eliminating accumulation; frankincense, assists pinellia and dried ginger, exerts its function of promoting qi, relieving pain and removing blood stasis; Roasted licorice, on the one hand, assists ginseng to invigorate the deficiency in the middle, on the other hand, reconciles various medicines to harmonize the properties of the medicine, which is beneficial to nourishing the stomach.

The preparation method of the present invention comprises: pulverizing 2/5 of the proportioning amount of ginseng into a fine powder and putting it aside for later use. Coptidis Rhizoma Coptidis in proportion is decocted with water, filtered, combined filtrates, concentrated under reduced pressure to a clear paste with a relative density of 1.10-1.15 (25°C), alcohol precipitation (to make the ethanol concentration reach 65%-75%), stirred evenly, and statically Set aside for 24 hours, filter, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.30-1.35 (50°C), dry at 80°C, and pulverize into fine powder; soak the proportioned amount of dried ginger in water, steam distillation to extract volatile oil , dregs and distilled water for later use. The volatile oil is clathrated with β-cyclodextrin, suction filtered, and the sediment is dried for later use; the above-mentioned medicinal residues are mixed with the proportioned amount of Scutellaria baicalensis, Magnolia officinalis officinalis, Zhigancao, Fa Pinellia, and 3/5 of the proportioned amount. Decoct with water, filter, combine the filtrate with the dried ginger after distillation, concentrate under reduced pressure to a clear paste with a relative density of 1.10-1.15 (25°C), precipitate with alcohol (to make the ethanol concentration reach 65%-75%), and stir evenly , stand still for 24 hours, filter, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.30-1.35 (50°C), add the above fine powder, stir evenly, dry at 80°C, crush into fine powder, and mix with Coptis chinensis extract Mix the powder and the clathrate evenly to obtain the traditional Chinese medicine composition of the present invention; the present invention can also continue to use the known techniques of traditional Chinese medicine to make any solid dosage form, including capsules, tablets, powders or pills.

Use the Chinese medicine composition for the treatment of chronic atrophic gastritis of the present invention to treat 60 cases of chronic atrophic gastritis, and the therapeutic effect is as follows:

Treat chronic atrophic gastritis with reference to the Ministry of Health's "Clinical Guidelines for the Treatment of Chronic Atrophic Gastritis with New Drugs of Traditional Chinese Medicine", "Diagnosis and Therapeutics of Modern Traditional Chinese Medicine", "Practical Internal Medicine of Traditional Chinese Medicine", and the textbook "Internal Science" of national medical colleges and universities. 60 cases of gastritis, TCM dialectics belong to mixed syndrome of cold and heat, clinical symptoms include stomach fullness, fullness, pain, loss of appetite, belching, noisy pantothenic acid, loose or dry stool, fatigue, weight loss, eating spicy, cold, greasy food stomach Distending pain and discomfort are mainly aggravated. The tongue is mainly pale or red, with thin white, yellow or greasy fur. The pulse is mainly deep and stringy, thin and slow. Among the 60 patients, 6 cases were clinically cured, accounting for 10%; 20 cases were markedly effective, accounting for 33%; 26 cases were effective, accounting for 43%; 8 cases were ineffective, accounting for 13%, and the total effective rate was 87%.

Detailed ways

Embodiment 1: A kind of Chinese medicine composition for the treatment of chronic atrophic gastritis of the present invention, carries out prescription according to monarch, minister, adjuvant, envoy: Fa Pinellia is monarch medicine; , frankincense is an adjuvant drug; Radix Glycyrrhiza is an envoy; and the composition and weight percentages of the Chinese medicine composition are: Pinellia chinensis 3.7%, Coptidis 18.5%, dried ginger 18.5%, ginseng 9.3%, scutellaria baicalensis 18.5%, thick Pu 9.3%, frankincense 3.7%, roasted licorice 18.5%.

Example 2:

A traditional Chinese medicine composition for treating chronic atrophic gastritis of the present invention is formulated according to monarch, minister, adjuvant and envoy: Fa Pinellia is the monarch drug; Coptidis Rhizoma, Dried Ginger, and Ginseng are minister drugs; Scutellaria baicalensis, Magnolia officinalis, and frankincense are assistants. Radix Glycyrrhiza is used as medicine; and the composition and weight percentage of the Chinese medicine capsule are: Pinellia chinensis 3.5%, Coptidis 19%, dried ginger 18%, ginseng 9.5%, Scutellaria baicalensis 18%, Magnolia officinalis 9.5%, frankincense 4% %, Zhi Licorice 18%.

Example 3:

A traditional Chinese medicine composition for treating chronic atrophic gastritis of the present invention is formulated according to monarch, minister, adjuvant and envoy: Fa Pinellia is the monarch drug; Coptidis Rhizoma, Dried Ginger, and Ginseng are minister drugs; Scutellaria baicalensis, Magnolia officinalis, and frankincense are assistants. Radix Glycyrrhiza is used as medicine; and the composition and weight percentage of the Chinese medicine capsule are: Pinellia 4%, Coptidis 18%, Dried Ginger 19%, Ginseng 9%, Scutellaria baicalensis 19%, Magnolia officinalis 9%, Frankincense 3.5% %, Zhi Licorice 19%.

Preparation method embodiment 1:

Get ginseng 100g (3.7%) and frankincense 100g (3.7%) and grind into fine powder, set aside. Add 500 g (18.5%) of Coptidis Rhizome to decoct with water, filter, combine the filtrates, concentrate under reduced pressure to a clear paste with a relative density of 1.10-1.15 (25°C), precipitate with alcohol (to make the ethanol concentration reach 65%-75%), stir evenly, Stand still for 24 hours, filter, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.30-1.35 (50°C), dry at 80°C, and pulverize into fine powder. Dried ginger 500g (18.5%) is soaked in water, steam distillation extracts volatile oil, medicinal residues and distilled water for later use. The volatile oil was clathrated with β-cyclodextrin, filtered with suction, and the precipitate was dried for later use. Decoct the above medicinal residues with 500g (18.5%) of Scutellaria baicalensis, 150g (5.6%) of ginseng, 250g (9.3%) of Magnolia bark, 500g (18.5%) of roasted licorice, and 100g (3.7%) of Pinellia chinensis, and filter. The filtrate and dried ginger are distilled and the water liquid is combined, concentrated under reduced pressure to a clear paste with a relative density of 1.10-1.15 (25°C), alcohol precipitation (making the ethanol concentration reach 65%-75%), stirring evenly, standing for 24 hours, and filtering After that, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.30-1.35 (50°C), add the above-mentioned fine powder, stir evenly, dry at 80°C, crush into fine powder, and mix evenly with Coptis chinensis extract powder and clathrate That is, the Chinese medicine composition of the present invention is obtained.

Preparation method embodiment 2:

Get ginseng 115g (4%) and frankincense 115g (4%) and grind into fine powder, set aside. Add 545g (19%) of Coptidis Rhizome to decoct with water, filter, combine the filtrates, concentrate under reduced pressure to a clear paste with a relative density of 1.10-1.15 (25°C), precipitate with alcohol (to make the ethanol concentration reach 65%-75%), stir evenly, Stand still for 24 hours, filter, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.30-1.35 (50°C), dry at 80°C, and pulverize into fine powder. Dried ginger 515g (18%) is soaked in water, steam distillation extracts volatile oil, medicinal dregs and water liquid after distillation are set aside. The volatile oil was clathrated with β-cyclodextrin, filtered with suction, and the precipitate was dried for later use. Add water to decoct the above-mentioned medicinal residues, 515g (18%) of Scutellaria baicalensis, 155g (5%) of ginseng, 270 bark officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis Magnolia officinalis officinalis Officinalis Magnolia officinalis Bark 270 (9.5%), Zhi licorice 515g (18%), Pinellia chinensis 100g (3.5%) and decoct in water, filter, The filtrate and dried ginger are distilled and the water liquid is combined, concentrated under reduced pressure to a clear paste with a relative density of 1.10-1.15 (25°C), alcohol precipitation (making the ethanol concentration reach 65%-75%), stirring evenly, standing for 24 hours, and filtering After that, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.30-1.35 (50°C), add the above-mentioned fine powder, stir evenly, dry at 80°C, crush into fine powder, and mix evenly with Coptis chinensis extract powder and clathrate That is, the Chinese medicine composition of the present invention is obtained.

Treatment example 1 of the present invention Yuan, male, 33 years old, from Changchun City. Suffering from bloating, stomach pain, weight loss for 1 year. Stomach pain every time with improper diet, sleepless all night. I usually have a full stomach, no appetite, dry and loose stools, easy to catch colds, and obvious body weight loss. Examined as chronic atrophic gastritis in many hospitals in the city. Look into: red tongue fur, white and greasy fur, deep and slow pulse. Diagnosed by traditional Chinese medicine as lump syndrome, syndrome differentiation is mixed cold and heat, treated with compound Xialian capsule decoction for 1 month, the symptoms were obviously relieved. The original prescription has been taken in a small amount for nearly 3 months, no symptoms at all, and weight gain. Follow up a case by regular visits to after 5 years, do not relapse again.

Treatment Example 2 of the present invention Hao, male, 45 years old, from Changchun City. Pain, fullness in the stomach, noisy for more than 10 years, aggravated for 1 year. Because he is a taxi driver, his diet is irregular, and his hunger and fullness are not adjusted to cause the disease. It was diagnosed as chronic atrophic gastritis by many hospitals in the city, and taking Chinese and Western medicines was ineffective. Ordinary loss of appetite, full stomach, noisy, stomach pain, often with hands against the stomach to relieve pain while driving. Dry and loose stools, easy fatigue, fatigue can not be relieved after sleep, the body is extremely thin, and the stomach feels comfortable when rubbed with hands. Look into pale tongue, thin yellow fur, thready pulse. The TCM syndrome is epigastric pain, and the syndrome is cold and heat mixed. Compound Xialian Capsule Decoction is used for treatment. After 2 weeks, the symptoms were obviously improved, and after 3 months, the symptoms disappeared. After 5 years of follow-up, there was no recurrence and the body was healthy.

Claims (2)

1. Chinese medicine composition for the treatment of chronic atrophic gastritis, according to monarch, minister, help, make and carry out the compatibility component, it is characterized in that: Rhizoma Pinelliae Preparatum is a monarch drug; Rhizoma Coptidis, Rhizoma Zingiberis, Radix Ginseng are ministerial drug; Radix Scutellariae, Cortex Magnoliae Officinalis, Olibanum are adjuvant drug; Radix Glycyrrhizae Preparata is a messenger drug; And the constituent of Chinese medicine composition and percentage by weight are: Rhizoma Pinelliae Preparatum 3.5%-4%, Rhizoma Coptidis 18%-19%, Rhizoma Zingiberis 18%-19%, Radix Ginseng 9%-9.5%, Radix Scutellariae 18%-19%, Cortex Magnoliae Officinalis 9%-9.5%, Olibanum 3.5%-4%, Radix Glycyrrhizae Preparata 18%-19%.

2. a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis according to claim 1, the constituent and the percentage by weight thereof that it is characterized in that this Chinese medicine composition are: Rhizoma Pinelliae Preparatum 3.7%, Rhizoma Coptidis 18.5%, Rhizoma Zingiberis 18.5%, Radix Ginseng 9.3%, Radix Scutellariae 18.5%, Cortex Magnoliae Officinalis 9.3%, Olibanum 3.7%, Radix Glycyrrhizae Preparata 18.5%.