CN100350925C - Novel snuff aerosol - Google Patents
Novel snuff aerosol Download PDFInfo
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- CN100350925C CN100350925C CNB2005101360575A CN200510136057A CN100350925C CN 100350925 C CN100350925 C CN 100350925C CN B2005101360575 A CNB2005101360575 A CN B2005101360575A CN 200510136057 A CN200510136057 A CN 200510136057A CN 100350925 C CN100350925 C CN 100350925C
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- snuff
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- camphora
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- 239000003814 drug Substances 0.000 claims abstract description 37
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a novel Chinese medicinal snuff without tobaccos, an aerosol which comprises the Chinese medicinal snuff and a preparation method of the Chinese medicinal snuff. The Chinese medicinal snuff has the formula that astragalus, angelica, longan aril, tangerine peel, white atractylodes rhizome and tuckahoe each has the proportion from 5 to 35 percents; panax ginseng, liquorice root, aucklandia root, dahurian angelica, curcuma aromatica, patchouli or/and centipeda, dried ginger, magnolia flower and Chinese honeylocust abnormal fruit or honeylocust each has the proportion from 1 to 20 percents, and mentha camphor, musk, camphol, benzoin and camphor each has the proportion from 0.1 to 10 percents. The aerosol of Chinese medicinal snuff of the present invention is filled with medicinal micro powder which has the particle diameter below 30 mu meters, and then the cell walls of medicinal materials are broken to reduce the digestion process of medicinal effect components. The Chinese medicinal snuff is brought into nasal cavities by spraying and absorbed by mucous membrane in nasal cavities to apply medicine in deep parts so as to attain the purposes of inducing reuscitation, refreshing, improving and treating fatigue, tire, spirit lassitude and dizziness, which has the function of wakening brain and refreshing mind quickly. Clinical experiments proves that the Chinese medicinal snuff has no obvious stimulation and sensitization on complete and damaged skin mucous membranes and no any toxic reaction on the inhalation of respiratory tracts, and can alleviate fatigue and refresh brains.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to the pure Chinese medicine Folium Nicotianae preparatum of a kind of novel no Nicotiana tabacum L., and contain aerosol of Chinese medicine Folium Nicotianae preparatum and preparation method thereof.
Background technology
Chinese medicine is thought, between each internal organs of human body, and between human body and the external environment, be in corresponding, unified process, to keep relative dynamic equilibrium, keeping the normal physiological activity of human body, causing that the reason of disease is exactly the cause of disease and destroy this relative balance state of human body.The cause of disease is diversified, mainly contains six climate exopathogens, epidemic miasma, seven emotions, diet, overstrain, and injures insect-animal injury etc. outward.Wherein, six climate exopathogens invasion and attack human body is gone into from skin, mouth and nose, all sees Table disease at the beginning of the morbidity; And seven emotions, overstrain directly influence corresponding internal organs, make its mechanism of qi disorderly contrary, and disorder of QI and blood produces sufferer.Impaired owing to healthy energy simultaneously, and exopathogen is had an opportunity to take advantage of, the invasion and attack human body.The modern is busy with one's work, psychentonia, life stress are big, through regular meeting occur working overtime, study in the late into the night, long-distance driving or the like situation, be in a tax on one's mind state of high-pressure for a long time, physical sport again relatively seldom simultaneously.If things go on like this, will certainly damage the body normal physiological state in the course of time.
Theory of Chinese medical science is thought: heart person, the viscus likened to the monarch in the body, here gods go out, and are the big master of the vital organs of the human body, spirit give up also.The traditional Chinese medical science theory of visceral outward manifestation belongs to the heart to people's spirit and consciousness and thinking activities system, and the five internal organs are brought into play its not same-action under the commander of the heart: heart storing spirit, main happiness; Liver storing soul, main angry; Idea stored in the spleen, main think of; Lung storing inferior spirit, main sad; Kidney storing will, probably main.Anger move in the heart then liver should, think to move in the heart then spleen should, compassion move in the heart then lung should, move probably that then kidney should in the heart.The physiological function of taking care main gods is normal, then shows in high spiritsly, and mind is clear, and thinking is quick, and normal phenomenon is quick on the draw.If ponder over excessive thinking and anxiety, or by feelings will hindered, five excessive emotions converting into internal fire, the consume painstaking effort, blood deficiency can not be moistened nourishing the heart to keep a sound mind, lack of preservation of spirit, restlessness confusing mind will occur refreshing knowing weakly, are difficult to concentrate single-minded, insomnia, dreaminess, mind are not peaceful, even delirium, lost in a reverie.Deficiency of heart-blood also can cause deficiency of heart-YANG, and the mind that the heart is led can not agitate, rouse oneself for yang-energy, so that spirit, will and thinking weaken, occur forgetful, spirit tired tired, the state of mind is weak, bradykinesia, mist is slept more, lazy speech low voice, very then stupor, syncope.Simultaneously, think then the heart and deposit to some extent, god returns to some extent, and healthy energy is stayed and is not all right, so the stagnation of QI, depressed.The stagnation of QI tie in, the dysfunction of the spleen can not the lucid yang sending up, the QI and blood literization is passive, QI of the upper portion of the body being insufficient, then brain is discontented.Then spiritlessness and weakness, the vertigo.Physical sport is very few, easily makes energy and blood of human body not smooth, and lack of appetite is weak, lassitude, moving then cardiopalmus.Moreover internal damage by the excessive seven emotions causes healthy energy impaired, human body susceptible exopathogen.Exopathogen " six climate exopathogens " is the general designation of six kinds of diseases caused by exogenous pathogenic factor pathogenic factor such as wind, cold, summer-heat, wet, dry, fire.Wherein, ailment said due to cold or exposure is apt to moving and is not occupied, and sends out because of it rises, and it is outside to be good at making progress, so often injure human body women's head-ornaments, yang channel, flesh table, makes fur space between skin and muscles using pungent drugs for dispersion and bitter drugs for purgation, more is subject to other exopathogen invasion and attack.Summer-heat being a kind of YANG pathogen, its property liter looses, and the normal disturbance mind is then vexed vexed random and not peaceful; Manyly again directly go into edema caused by disorder of QI, cause the space between skin and muscles using pungent drugs for dispersion and bitter drugs for purgation and hyperhidrosis then consumes impairment of body fluid liquid, right gas causes the deficiency of vital energy eventually with body fluid outflowing, shortness of breath and fatigue then, sudden faint very then, syncope.Because of heat is steamed wet moving, so summer-heat often mixed with damp.Moist heavy, clear YANG failing to ascend, disharmony of nutrient QI with defensive QI, so dizzy and heavy as bundle cloth and silk, it is heavy that the whole body is stranded, extremity are listless and aching heavy.Wet is YIN pathogen again, and the moon is held back mechanism of qi, the damage yang-energy.Burning hot YANG pathogen on its property inflammation, upsets gods, then vexed insomnia, unconsciousness and delirium; Burning hot property, burning burns burns flame, the cloudy liquid that burns that disappears, leak in urgent Tianjin, and Tianjin of general, weakness of QI are taken off, and is most damage healthy energy.Burning hot corresponding with the heart, and heart governing blood and vessels, house mind, pathogenic fire is disturbed the heart, mind uneasiness then, and agitation, or delirium goes mad, or go into a coma.As seen, overwork brings suitable severe impairment can for people's health.Therefore, in line with the principle of " prevention of diseae, preventing exacerbation after being taken ill ", the health product of developing effective fatigue alleviating, the every physiological function of enhancement human body is very necessary.
The invention of former traditional Folium Nicotianae preparatum is in Italy, and China is imported into 29 years Wanli year in the Ming Dynasty, and the main component of traditional Folium Nicotianae preparatum is a Nicotiana tabacum L., is aided with Chinese crude drug such as Moschus and adds some plant perfumes again, and various Folium Nicotianae preparatum prescriptions are identical substantially, all is to be major ingredient with first-class suncured tabacco.The shortcoming of existing Folium Nicotianae preparatum is: major ingredient is a Nicotiana tabacum L., has habit-forming property.Because technology falls behind, the former abrasive lapping of Folium Nicotianae preparatum can only reach 200 purpose levels, and the cell wall of medicine is not broken, and bioavailability is extremely low.The tradition method of getting it filled is that hands is twisted with the fingers, and sucks, and dosage is inaccurate, and extremely unhygienic.
Summary of the invention
One object of the present invention is to provide a kind of vigorate qi and replenish the blood, and refreshment does not have the pure Chinese medicinal preparation of Nicotiana tabacum L..
Another object of the present invention is to provide a kind of novel pure Chinese medicine snuff aerosol that does not have Nicotiana tabacum L..
Novel snuff aerosol of the present invention (Xi Lema Folium Nicotianae preparatum) comprises micro powder type and two kinds of aerosols of quintessence oil type.
Snuff aerosol of the present invention is achieved by following technology:
A kind of micro powder type snuff aerosol is characterized in that: its raw material comprises the composition of following portions by weight ratio:
Moschus 0.1 ~ 10 Borneolum Syntheticum 0.1 ~ 10 Benzoinum 0.1 ~ 10 Camphora 0.1 ~ 10 Mentholum 0.1 ~ 10
Fructus Gleditsiae Abnormalis 1 ~ 20 Radix Angelicae Dahuricae 1 ~ 20 Flos Magnoliae 1 ~ 20 Herba Pogostemonis 1 ~ 20.
A kind of quintessence oil type snuff aerosol, it is characterized in that: its raw material comprises the composition of following portions by weight ratio:
Moschus 0.1 ~ 10 Borneolum Syntheticum 0.1 ~ 10 Benzoinum 0.1 ~ 10 Camphora 0.1 ~ 10 Mentholum 0.1 ~ 10
Fructus Gleditsiae Abnormalis 1 ~ 10 Radix Angelicae Dahuricae 5 ~ 20 Flos Magnoliaes 5 ~ 20 Herba Pogostemonis 5 ~ 20.
According to patient's different situations, on the basic recipe basis of above-mentioned fine powder type and two kinds of aerosols of quintessence oil type, can also add the raw material of ratio of weight and number:
The Radix Astragali 5～35 Radix Angelicae Sinensis 5～35 Arillus Longans 5～35 Pericarpium Citri Reticulataes 5～35 Rhizoma Atractylodis Macrocephalaes 5～35 Poria 5～35
Radix Ginseng 1～20 Radix Glycyrrhizae 1～20 Radix Aucklandiae 1～20 Radix Curcumae 1～20 Rhizoma Zingiberis 1～20.Can carry out suitable adjustment as required.Wherein said Herba Pogostemonis can substitute with Herba Centipedae; Fructus Gleditsiae Abnormalis can substitute with Fructus Gleditsia.
Two kinds of aerosols of fine powder type of the present invention and quintessence oil type, walk to scurry with Moschus, Borneolum Syntheticum, Benzoinum, Camphora, the hot perfume (or spice) of Mentholum, the refreshment of having one's ideas straightened out, the clear sharp head is monarch drug altogether, reduce phlegm wet with Fructus Gleditsiae Abnormalis, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Pogostemonis, clearing the nasal passage is warded off and is disliked the dirty ministerial drug that is altogether, strengthens have one's ideas straightened out refreshment, the clear sharp head's effect of monarch drug.
The preparation method of micro powder type snuff aerosol of the present invention is characterized in that carrying out as follows:
(1) by a certain percentage with pulverizing such as Fructus Gleditsiae Abnormalis, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Pogostemonis, sieve and make particle diameter and be generally 1～100 μ m, preferred 1～30 μ m, more preferably the following powder of 30 μ m is standby.
(2) by a certain percentage Moschus, Borneolum Syntheticum, Benzoinum, Camphora, Mentholum are ground, mixing is made homogenate;
(3) standby (1) gradation is added in the homogenate, sieve, spray into edible essence, sealing is placed and is spent the night;
(4) utilize the instant sterilizer sterilization, fill is made finished product in the container that has aerosol apparatus (valve or pump) then.
The preparation method of quintessence oil type snuff aerosol of the present invention is characterized in that carrying out as follows:
(1) by a certain percentage Fructus Gleditsiae Abnormalis, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Pogostemonis, Benzoinum etc. are mixed with 40～100% ethanol extractions 1～3 time, filter standby;
(2) take by weighing the extracting solution that a certain amount of refined plant oil content extracts (1) gained for 1～3 time in addition, fully stir, breakdown of emulsion leaves standstill, and it is standby to separate oil reservoir;
(3) by a certain percentage Moschus, Borneolum Syntheticum, Camphora, Mentholum are ground, mixing is made homogenate, adds extraction oil, the edible essence of (2) gained, and mixing is standby;
(4) utilize the instant sterilizer sterilization, add fill then in the container that has aerosol apparatus (valve or pump), make finished product.
The present invention in aerosol mode (promptly being power and drug administration carrier) with the propellant with drug powder (particle diameter is 1～100 μ m) or/and extract is brought nasal cavity into, absorb by bronchia mucosal, the purpose of symptoms such as reaching has one's ideas straightened out refreshes oneself, and improvement and treatment spiritlessness and weakness, tired mind, dizziness, memory weaken, spirit can not be concentrated.
The medical material Radix Astragali tonifying Qi and lifting yang that the present invention is used in order to enriching spleen-QI, rises heart-yang.Chinese angelica blood supplementing is invigorated blood circulation, in order to the painstaking effort of tonification consume.Arillus Longan reinforcing the heart spleen, replenishing QI and blood is in order to invigorating the heart and spleen two void, insufficiency of vital energy and blood.During Pericarpium Citri Reticulatae is regulated the flow of vital energy and is transferred, in order to dredge temper, tonify without causing stagnation.Rhizoma Atractylodis Macrocephalae air making-up and spleen enlivening, the dampness diuretic in order to strong activating the spleen gas, rises digesting and absorbing the essence of foodstuff.Poria spleen invigorating eliminating dampness by diuresis, in order to fortune a little less than improving spleen late, water is wet to stop holding.The Radix Ginseng strongly invigorating primordial QI, invigorating the spleen to benefit the lung, multiple arteries and veins promotes the production of body fluid, in order to warmly invigorating heart-YANG.The Radix Glycyrrhizae invigorating the spleen and replenishing QI relaxes the property of medicine, in order to be in harmonious proportion the property of medicine.During Radix Aucklandiae circulation of qi promoting is transferred, in order to dredge temper, tonify without causing stagnation.The diffusing wind of the Radix Angelicae Dahuricae is sensible, in order to reach on the fragrance, is open to the custom and has one's ideas straightened out.The Radix Curcumae regulating qi to disperse stagnation clears away heart-fire in order to removing heat from blood, activating QI to alleviate the depression.The Herba Pogostemonis eliminating turbid pathogen with aromatics looses burnt turbid damp in the change in order to fragrance is capable.The Rhizoma Zingiberis warming middle-JIAO, recuperating depleted YANG is promoted blood circulation, and is supporing yang in order to the logical heart, helps the taste yang-energy again.Magnoliae Powder wind is sensible, in order to up women's head-ornaments, clearing the nasal passage.The Mentholum dispelling wind and heat pathogens, the clear sharp head, floating in order to the liter that lightly floats, the clear sharp head.Fructus Gleditsia is eliminated the phlegm and has one's ideas straightened out, and it is turbid to reduce phlegm in order to dispel, logical the closing of having one's ideas straightened out.The Moschus refreshment of having one's ideas straightened out, promoting blood circulation to remove obstruction in the collateral is walked to scurry in order to Xin Xiang, logical the closing of having one's ideas straightened out.The Borneolum Syntheticum refreshment clearing away heat to alleviate pain of having one's ideas straightened out, hot in order to fragrance, open hole powder is strongly fragrant.Benzoinum is had one's ideas straightened out and is warded off dirtyly, and it is turbid to dispel in order to dissipating depression of QI.Camphora is had one's ideas straightened out and is warded off dirtyly, walks to scurry in order to Xin Xiang, logical the closing of having one's ideas straightened out.Camphora is had one's ideas straightened out and is warded off dirtyly, walks to scurry in order to Xin Xiang, logical the closing of having one's ideas straightened out.Above-mentioned medical material is through extracting each effective ingredient, mixing the back walks to scurry with Moschus, Borneolum Syntheticum, Benzoinum, Camphora, the hot perfume (or spice) of Mentholum, the refreshment of having one's ideas straightened out, the clear sharp head is monarch drug altogether, reduce phlegm wet with Fructus Gleditsiae Abnormalis, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Pogostemonis, clearing the nasal passage is warded off and is disliked the dirty ministerial drug that is altogether, strengthens have one's ideas straightened out refreshment, the clear sharp head's effect of monarch drug.
In development, the inventor has at first done a large amount of screening operations on prescription and matrix formulations, formulated the prescription of science.In order to guarantee product quality, formulated to comprise sense indexs such as color and luster, outward appearance, abnormal smells from the patient, impurity; Physical and chemical indexs such as volatile oil content; The comprehensive quality standard of sanitary indexs such as hydrargyrum, arsenic, lead, microorganism.Also security of products is done a lot of work simultaneously, carried out a series of pharmacological toxicology experimentatioies such as respiratory tract suction acute toxicity test, skin (mucosa) irritant test, skin (mucosa) hypersensitive test according to " cosmetics health standard " relevant technological guidance's principle of version in 2002 that Ministry of Public Health issues.
The result shows that " Xi Lema board Folium Nicotianae preparatum " (micro powder type, quintessence oil type) all do not have obvious stimulation, sensitization to complete and damaged skin (mucosa), and respiratory tract is sucked more without any toxic reaction.In order to investigate the effectiveness of product, 64 routine clinical verifications have been carried out in Tianjin National Hospital, the result prove " Xi Lema board Folium Nicotianae preparatum " (micro powder type, quintessence oil type) to spiritlessness and weakness, tired mind, dizziness, memory weaken, spirit can not concentrate specially good effect, and onset is rapid, easy to use, welcome by the patient.
" Xi Lema board Folium Nicotianae preparatum " (micro powder type, quintessence oil type) clinical observation on the therapeutic effect:
The 64 examples volunteers that know the inside story: 38～60 years old age suffer from symptoms such as in various degree spiritlessness and weakness, tired mind, dizziness, memory weakens, spirit can not be concentrated, accept 1～7 day continuous treatment of aerosol of the present invention.
As a result, in 50 routine spiritlessness and weakness patients, that uses remission at once behind this medicine has 47 examples (94%), medication after 1 day remission 2 examples (4%) are arranged, continuous use did not take effect in 3 days 1 example (2%).1 example that does not take effect through inquiry, is regular insomniac, does not belong to this product and is suitable for the crowd.
In 54 routine tired mind patients, that uses remission at once behind this medicine has 52 examples (96%), medication after 1 day remission 1 example (2%) arranged, continuous use did not take effect in 3 days 1 example (2%, reason is the same).
In 58 routine dizzy patients, that uses remission at once behind this medicine has 57 examples (98%), medication after 1 day remission 1 example (2%) arranged.
Weaken among the patient in 60 routine memory, that uses remission at once behind this medicine has 38 examples (63%), medication after 3 days remission 12 examples (20%) are arranged, continuous use did not take effect in 7 days 10 examples (17%).
Can not concentrate among the patient in 57 routine spirit, that uses remission at once behind this medicine has 42 examples (74%), medication after 3 days remission 10 examples (17%) are arranged, continuous use did not take effect in 7 days 5 examples (9%).
Above result shows suction micro powder type, quintessence oil type snuff aerosol, can obviously improve the mental status (seeing Table 1).
Each sick curative effect of planting is (table 1) relatively
| Symptom * | The example number | Invalid | Effectively | Produce effects | Effective percentage |
| The dizzy memory of spiritlessness and weakness tired mind weakens spirit and can not concentrate | 50 54 58 60 57 | 1 1 0 10 5 | 2 1 1 12 10 | 47 52 57 38 42 | 98％ 98％ 100％ 83％ 91％ |
*Annotate: above five kinds of symptoms occur multiple situation on one's body same patient.
Snuff aerosol of the present invention (Xi Lema Folium Nicotianae preparatum) is with the good effect of traditional Folium Nicotianae preparatum:
1, is major ingredient with the Chinese herbal medicine, avoided the injury of nicotine, overcome addiction human body.Chinese herbal medicine has been selected vigorate qi and replenish the blood, and spleen invigorating is regulated the flow of vital energy, and the raw material of refreshment reaches logical hundred arteries and veins after the people is sucked, reaches nine orifices, accent maincenter, keeps away the effect of pestilence.
2, traditional Folium Nicotianae preparatum is based on Nicotiana tabacum L., the effect of a sense of taste is only played in the adding of Chinese herbal medicine, and the effect of refreshing oneself is mainly by nicotine, and long-term the suction damages human body, snuff aerosol of the present invention does not contain the useful composition that Nicotiana tabacum L. is all extracted with natural drug, enters human body by bronchia mucosal.With the general particle diameter of drug powder is 1～100 μ m, preferred 1～30 μ m, more preferably can reach below the 30 μ m, the Chinese herbal medicine cell wall of this moment is broken, reduced the process in leaching of active ingredient, bring nasal cavity into by Sprayable, absorb by bronchia mucosal, the depths administration, medicine becomes fine mist to spread in nasal mucosa, and bioavailability of drugs is greatly improved, and reaching has one's ideas straightened out refreshes oneself, the purpose of symptoms such as improvement and treatment spiritlessness and weakness, tired mind, dizziness, memory weaken, spirit can not be concentrated plays the effect of quick refreshment.
The specific embodiment
The present invention will be further described below in conjunction with embodiment:
Embodiment 1
Micro powder type Xi Lema board snuff aerosol
1, prescription:
Radix Astragali 10g, Radix Angelicae Sinensis 10g, Arillus Longan 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Radix Ginseng 5g, Radix Glycyrrhizae 5g, Radix Aucklandiae 5g, Radix Angelicae Dahuricae 4g, Radix Curcumae 4g, Herba Pogostemonis 4g, Rhizoma Zingiberis 4g, Flos Magnoliae 2g, Fructus Gleditsiae Abnormalis 1.5g, Mentholum 1.6g, Moschus 1g, Borneolum Syntheticum 1g, Benzoinum 1g, Camphora 0.4g, edible essence 0.5g make 100g altogether.
2, preparation technology:
With ten five tastes such as the Radix Astragali, Radix Angelicae Sinensis, Arillus Longan, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Ginseng, Radix Glycyrrhizae, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Radix Curcumae, Herba Pogostemonis, Rhizoma Zingiberis, Flos Magnoliae, Fructus Gleditsiae Abnormalis, mix pulverizing or pulverize separately and become 60 order to 100 purpose fine powders, mixing, micronizing is micropowder (particle diameter is 1～100 μ m), and is standby.In addition, the five tastes such as Mentholum, Moschus, Borneolum Syntheticum, Benzoinum, Camphora, facing-up is after grinding well, above-mentioned micropowder is slowly added, continue to grind, until evenly, utilize the instant sterilizer sterilization, fill is made finished product in the container that has aerosol apparatus (valve or pump) then.
Embodiment 2
Quintessence oil type Xi Lema board snuff aerosol
1, prescription:
Radix Astragali 10g, Radix Angelicae Sinensis 10g, Arillus Longan 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Radix Ginseng 5g, Radix Glycyrrhizae 5g, Radix Aucklandiae 5g, Radix Angelicae Dahuricae 4g, Radix Curcumae 4g, Herba Pogostemonis 4g, Rhizoma Zingiberis 4g, Flos Magnoliae 2g, Fructus Gleditsiae Abnormalis 1.5g, Mentholum 1.6g, Moschus 1g, Borneolum Syntheticum 1g, Benzoinum 1g, Camphora 0.4g, edible essence 0.5g make 100g altogether.
2, preparation technology:
Ten Six-elements such as the Radix Astragali, Radix Angelicae Sinensis, Arillus Longan, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Ginseng, Radix Glycyrrhizae, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Radix Curcumae, Herba Pogostemonis, Rhizoma Zingiberis, Flos Magnoliae, Fructus Gleditsiae Abnormalis, Benzoinum are mixed with 90% ethanol extraction secondary, merge extracted twice liquid, filter standby; Other takes by weighing 1 ~ 3 ethanol extraction extracting solution of a certain amount of refined plant oil content, fully stirs, and breakdown of emulsion leaves standstill, and it is standby to separate oil reservoir; Then four flavors such as Moschus, Borneolum Syntheticum, Mentholum, Camphora are ground, mixing is made homogenate; Add above-mentioned extraction oil, edible essence, mixing utilizes the instant sterilizer sterilization, and fill is made finished product in the container that has aerosol apparatus (valve or pump) then.
Embodiment 3
Prescription: Herba Pogostemonis g, Radix Angelicae Dahuricae 4g, Flos Magnoliae 2g, Fructus Gleditsiae Abnormalis 1.5g, Camphora 0.7g, Mentholum 2g, Moschus 0.5g, Borneolum Syntheticum 1.2g, Benzoinum 2g, Camphora 0.4g, edible essence 0.5g.Preparation method is with embodiment 1.
Embodiment 4
Prescription: Herba Pogostemonis 5g, Radix Angelicae Dahuricae 4.5g, Flos Magnoliae 2.2g, Fructus Gleditsiae Abnormalis 2g, Camphora 1.7g, Mentholum 0.7g, Moschus 1g, Borneolum Syntheticum 1.7g, Benzoinum 21g, Camphora 0.4g, edible oil 2.5g.Preparation method is with embodiment 2.
Embodiment 5
Prescription: Radix Angelicae Sinensis 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Ginseng 10g, Radix Aucklandiae 5g, Radix Angelicae Dahuricae 14g, Radix Curcumae 4g, Herba Pogostemonis 14g, Rhizoma Zingiberis 4g, Flos Magnoliae 12g, Fructus Gleditsiae Abnormalis 1.5g, Mentholum 1.6g, Moschus 1g, Borneolum Syntheticum 1g, Benzoinum 1g, Camphora 0.4g, edible essence 0.5g.Preparation method is with embodiment 2.
Claims (7)
1, a kind of micro powder type snuff aerosol is characterized in that it comprises the crude drug of following portions by weight ratio:
Moschus 0.1 ~ 10 Borneolum Syntheticum 0.1 ~ 10 Benzoinum 0.1 ~ 10 Camphora 0.1 ~ 10 Mentholum 0.1 ~ 10
Fructus Gleditsiae Abnormalis 1 ~ 20 Radix Angelicae Dahuricae 1 ~ 20 Flos Magnoliae 1 ~ 20 Herba Pogostemonis 1 ~ 20.
2, a kind of quintessence oil type snuff aerosol is characterized in that it comprises the crude drug of following portions by weight ratio:
Moschus 0.1 ~ 10 Borneolum Syntheticum 0.1 ~ 10 Benzoinum 0.1 ~ 10 Camphora 0.1 ~ 10 Mentholum 0.1 ~ 10
Fructus Gleditsiae Abnormalis 1 ~ 10 Radix Angelicae Dahuricae 5 ~ 20 Flos Magnoliaes 5 ~ 20 Herba Pogostemonis 5 ~ 20.
3, snuff aerosol as claimed in claim 1 or 2 is characterized in that also comprising the crude drug of following portions by weight ratio:
The Radix Astragali 5 ~ 35 Radix Angelicae Sinensis 5 ~ 35 Arillus Longans 5 ~ 35 Pericarpium Citri Reticulataes 5 ~ 35 Rhizoma Atractylodis Macrocephalaes 5 ~ 35 Poria 5 ~ 35
Radix Ginseng 1 ~ 20 Radix Glycyrrhizae 1 ~ 20 Radix Aucklandiae 1 ~ 20 Radix Curcumae 1 ~ 20 Rhizoma Zingiberis 1 ~ 20.
4, snuff aerosol as claimed in claim 1 or 2, Herba Pogostemonis wherein substitutes with Herba Centipedae; Fructus Gleditsiae Abnormalis substitutes with Fructus Gleditsia.
5, the preparation method of the defined micro powder type snuff aerosol of a kind of claim 1 is characterized in that carrying out as follows:
(1) Fructus Gleditsiae Abnormalis, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Pogostemonis are pulverized, sieving, it is standby to make powder;
(2) Moschus, Borneolum Syntheticum, Benzoinum, Camphora, Mentholum are ground, mixing is made homogenate;
(3) standby (1) gradation is added in the homogenate, sieve, spray into edible essence, sealing is placed and is spent the night;
(4) utilize the instant sterilizer sterilization, fill is made finished product in the container that has valve aerosol apparatus or pump sprayer then.
6, the preparation method of the defined quintessence oil type of a kind of claim 2 snuff aerosol is characterized in that carrying out as follows:
(1) Fructus Gleditsiae Abnormalis, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Pogostemonis, Benzoinum etc. are mixed with 40 ~ 100% ethanol extractions 1 ~ 3 time, filter standby;
(2) take by weighing the extracting solution that the refined plant oil content extracts (1) gained for 1 ~ 3 time in addition, fully stir, breakdown of emulsion leaves standstill, and it is standby to separate oil reservoir;
(3) Moschus, Borneolum Syntheticum, Camphora, Mentholum are ground, mixing is made homogenate, adds extraction oil, the edible essence of (2) gained, and mixing is standby;
(4) utilize the instant sterilizer sterilization, fill is made finished product in the container that has valve aerosol apparatus or pump sprayer then.
7, the preparation method of micro powder type snuff aerosol as claimed in claim 5 is characterized in that, described powder diameter is 1～100 μ m.
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| CNB2005101360575A CN100350925C (en) | 2005-12-30 | 2005-12-30 | Novel snuff aerosol |
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| CNB2005101360575A CN100350925C (en) | 2005-12-30 | 2005-12-30 | Novel snuff aerosol |
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| CN100350925C true CN100350925C (en) | 2007-11-28 |
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| CNB2005101360575A Expired - Fee Related CN100350925C (en) | 2005-12-30 | 2005-12-30 | Novel snuff aerosol |
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