CN104147518A - Traditional Chinese medicinal capsule for treating depression and preparation method thereof - Google Patents
Traditional Chinese medicinal capsule for treating depression and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal capsule, and in particular to a traditional Chinese medicinal capsule for treating depression and a preparation method thereof. The traditional Chinese medicinal capsule for treating depression is prepared from the following traditional Chinese medicinal materials by weight: 10-15 parts of Hypericum perforatum, 10-15 parts of acanthopanax, 10-15 parts of turmeric, 2-5 parts of Ganoderma lucidum, 5-7 parts of Poria cocos, 2-5 parts of bambusae caulis im taeniam, 2-5 parts of dried orange peel, 5-7 parts of flower of silktree albizzia, 2-5 parts of lily and 2-5 parts of Herba Rhodiolae. The preparation method comprises the following steps: 1) weighing the raw materials according to the weight ratio, adding water and decocting two times, wherein 8 times amount of water is added each time, decocting 2 h for the first time, decocting 1 h for the second time, merging the filtrates, filtering, and drying into a fine powder; 2) adding anhydrous glucose powder into the fine powder obtained in step 1) and mixing evenly; and 3) filling the mixed powder into a capsule filling machine, so as to obtain capsules of 0.5-0.6 g per capsule. The capsule has the advantages of high safety, no toxic or side effect, no dependence, stable and controllable quality, convenience for carrying and administration, and simple preparation process.
Description
Technical field
The present invention relates to a kind of Chinese medicinal capsule, be specifically related to Chinese medicinal capsule of a kind of Cure of depression and preparation method thereof.
Background technology
Depression is a kind of common emotion and mental disorder disease, and along with the quickening of social life rhythm, depression has become the disease occurred frequently of society.In current life, be full of big and small setback and failure, a lot of people can experience unemployment, divorce, lose darling, or other various miseries.The thing that usually we dream of most, it has not again existed, the people of our favorite usually, then can not come back to us.When these arrive constantly, we can experience sadness, misery, even desperate.Conventionally, what by these clear and definite actual events, caused is depressed and sad, is normal, of short duration, and what have is even conducive to individual growth.But some people's depressive symptom is very clear and definite, rational outside inducement not; The others, although in their life, there are some negative life events,, their depressive symptom continues for a long time, considerably beyond the emotional responses of common people to these events, and depressive symptom worsens increasingly, seriously affected work, living and studying.If so, so probably, their first mental illness in the Huan Liao world today---depression.
Depression just, in our life, just, around us, all may occur whenever and wherever possible.Up to the present, the definite cause of disease of depression is not clear.Along with medical model is converted to present biology, psychology, social medicine pattern from the biomedicine in past, depression is the same with other diseases, should from these three angles, go to analyze the cause of disease, i.e. biological factor, psychological factor and social factor.
People lives in society, and its life-span, health and disease are invariably closely bound up with it, people's worry, happiness, grief, happy, anxiety etc., and everything maintains or the emotion of destroying people's normal physiological function is all closely connected with society.Living condition comprises the variation of society, culture and objective environment, the variation of marriage, family, individual health and inter personal contact, the variation of economic condition, individual school work success or failure etc.Allly in life can cause powerful stress, the conditions such as serious psychic trauma or depression experience all can become psychological factor.
The biological etiology of relevant depression was familiar with before more than 30 years, development along with investigative technique, make great progress, the cause of disease to depression, physiopathologic understanding have been deepened, more outstanding understanding is, unstrung variation due to Cucumber in body, as (1) noradrenaline theory (NE): thought at that time depression be the shortage of catecholamine, especially NE in brain or relatively lack due to.From clinical treatment, can obtain some checking, yet still there are many problems in this single theory.(2) serotonin theory (5-HT): more and more deep to the research of this hypothesis in the last few years, it is relevant with affective activity that to be embodied blood hypotype also a lot, different receptor subtype functions is different again, from the angle for the treatment of, supports depression and the handicapped relevant theory of 5-HT.
A lot of endocrinopathyes, as hyperthyroidism or low, Addison disease, cushing's disease etc. can be with emotion symptoms, and various hormones can cause that mental state is surging or low, make people expect may there be relation between neuroendocrine and depression, also accumulated a large amount of research datas.In recent years, development due to biotechnology, the clinical practice of electronic computer scanning (CT), nuclear magnetic resonance, NMR (MRI), positron emission tomography (PET) and single photon emission computed scanning (SPECT), people also find that the brain function of depressive patients or brain structure may change.Also there are people and inherited genetic factors, characteristics of personality relevant.In a word, the cause of disease of depression is complicated, and countries in the world are still among constantly studying at present.Therefore, the drug research of reinforcement Cure of depression has important society and economic implications.
Summary of the invention
According to above the deficiencies in the prior art, the invention provides a kind of Chinese medicine that is used for the treatment of depression, its effective substance is substantially clear and definite, quality controllable, and can dispersing the stagnated live-QI to relieve the stagnation of QI, mind tranquilizing and the heart calming, produce synergism, raising evident in efficacy.The present invention aims to provide a kind of better efficacy clinically, Chinese medicinal capsule more easily.
The Chinese medicinal capsule of a kind of Cure of depression of the present invention, according to parts by weight meter, formulated by following raw material of Chinese medicine: Herba Hyperici Monogyni 10-15 part, Radix Et Caulis Acanthopanacis Senticosi 10-15 part, Radix Curcumae 10-15 part, Ganoderma 2-5 part, Poria 5-7 part, Caulis Bambusae In Taenia 2-5 part, Pericarpium Citri Reticulatae 2-5 part, Flos Albiziae 5-7 part, Flos Lilii viriduli 2-5 part, Radix Rhodiolae 2-5 part.
A Chinese medicinal capsule for Cure of depression, according to parts by weight meter, formulated by following preferred raw material of Chinese medicine: 13 parts of Herba Hyperici Monogynis, 13 parts of Radix Et Caulis Acanthopanacis Senticosis, 13 parts of Radix Curcumaes, 3 parts of Ganodermas, 6 parts, Poria, 3 parts of Caulis Bambusae In Taenia, 3 parts of Pericarpium Citri Reticulataes, 6 parts of Flos Albiziaes, 3 parts of Flos Lilii viridulies, 3 parts of Radix Rhodiolaes.
A preparation method for the Chinese medicinal capsule of Cure of depression, comprises the following steps:
1) by above-mentioned weight ratio weighting raw materials, decoct with water twice, add 8 times of water gagings at every turn, decoct for the first time 2 hours, decoct for the second time 1 hour, merging filtrate, after filtration, is dried to fine powder;
2) by step 1) in fine powder add anhydrous grape Icing Sugar mix homogeneously;
3) above-mentioned mixed-powder is put into capsule filling machine and carry out filling, obtain the capsule of every 0.5-0.6 gram.
Pharmacology analysis:
Herba Hyperici Monogyni: main component is that hypericin, pseudohypericin etc. have the multiple effects such as antidepressant, antiviral, treatment wound.Three grades are xeothermic, mildly bitter flavor, and raw dry heat-dissipating, stimulates the menstrual flow, logical urine, logical retardance, the pain that relieves the pain, except necrotic tissue and promoting muscle growing.
Radix Et Caulis Acanthopanacis Senticosi: effect feature and the Radix Ginseng of Radix Et Caulis Acanthopanacis Senticosi are basic identical, has the body of adjusting disorderly, makes it to be tending towards normal function.There is good antifatigue effect, remarkable compared with Radix Ginseng, and can significantly improve hypoxia-bearing capability.The functions such as invigorating middle warmer, benefit essence, strong will, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, stomach invigorating diuresis.Take for a long time " make light of one's life by commiting suicide and endure hardships ".Radix Et Caulis Acanthopanacis Senticosi contains noticeable composition---eleutheroside, and it can stimulate mind & body vigor, can resisting fatigue, strengthen endurance and ability, and increase alertness and learning capacity.Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, for deficiency of spleen-YANG and kidneyYANG, soreness of the waist and knees, body void is weak, insomnia and dreamful sleep, inappetence, blood vessel dilating, blood pressure lowering, rises hemocyte in addition, antitumor, the effect of resisting fatigue.
Radix Curcumae: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, removing heat from blood clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice, for obnubilation, blood stasis internal resistance etc.
Ganoderma: calm the nerves, protect god, enter the heart being responsible for production of blood, help the heart to fill arteries and veins, the liver benefiting, lung, spleen, anti-cancer antitumor, anti-radiation, prevents hepatitis, heart tonifying, coordinates human body metabolism, and clothes of a specified duration are made light of one's life by commiting suicide not old, and life lengthening, containing several amino acids.
Poria: slightly sweet flavor is flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.
Caulis Bambusae In Taenia: cold nature, sweet in the mouth.Cure mainly removing heat-phlegm, relieve restlessness and prevent vomiting.For phlegm-heat cough, gallbladder fire, hold expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm.
Pericarpium Citri Reticulatae: acrid in the mouth and micro-hardship, temperature, enters spleen, lung meridian.Cure mainly in reasonable controlled atmosphere, drying dampness to eliminate phlegm effect, can be used for treating stagnation of QI in spleen and stomach, distension and fullness in the abdomen, vomiting, or uncomfortable in chest due to turbid damp obstructing in middle-JIAO, indigestion and loss of appetite, loose stool.
Flos Albiziae: sweet in the mouth, property is flat, have remove depressed, settling five organs, the effect of improving eyesight, can treat the depressed insomnia causing and binocular dim, the resolving depression of calming the nerves, promoting blood circulation and detumescence, the indignation of hindering for feelings will is melancholy, fidgets due to deficiency is uneasy.
Flos Lilii viriduli: bitter in the mouth, cold nature.Enter the heart, lung meridian.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.There is nourishing YIN and moistening the lung cough-relieving effect, for the cough caused by dryness-heat of deficiency of lung-YIN, as all sorts of flowers cream.Control chronic cough of deficiency lung, chronic cough spitting of blood, as baihe gujin decoction.There is clearing away heart-fire for tranquillization effect, unclear for calentura waste heat, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep etc.
Radix Rhodiolae: can QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae is nourished heart, and sweetness and bitterness is flat.Return lung heart channel.Benefiting QI for activating blood circulation, promotes blood circulation and relievings asthma.For blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.
The invention has the advantages that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, pure Chinese medicine combination capsule in the present invention is upset to regulate function of human body to reach to improve, or cardiopalmus, and then it is weighed down with anxieties to reach treatment, upset, the effect of cardiopalmus depression.That Chinese medicine composition of the present invention has is safe, have no side effect, no dependence, stable and controllable for quality, be easy to carry and take, the advantage such as preparation technology is simple.
Efficacy evaluation:
Cure: clinical symptom disappearance, does not affect working and learning, with examining 2 months without recurrence;
Effective: symptom and sign disappear substantially, only under a few cases, there is mild, do not affect work and life;
Take a turn for the better: symptom alleviates, sign is improved, but has recurrence, and people's life and work is had to impact;
Invalid: symptom and sign is not improved or increases the weight of.
Collect 120 routine patients with depression, be divided at random treatment group 1, treatment group 2, treatment group 3, matched group, every group of 30 examples; Man's 60 examples, female's 60 examples; Age 18-45 year, average 30 years old; The course of disease is the longest 1 year, the shortest 2 weeks, average approximately 2 months.Each is organized patient age symptom and forms without significant difference; Treatment group patient takes preparation of the present invention and treats, and once-a-day, serve on 2 months.
Statistical result is as follows:
| ? | Cure | Effective | Take a turn for the better | Invalid | Effective percentage |
| Contrast | 0 | 0 | 0 | 30 | 0 |
| Treatment group 1 | 13 | 10 | 7 | 2 | 95％ |
| Treatment group 2 | 10 | 8 | 9 | 3 | 92％ |
| Treatment group 3 | 12 | 11 | 5 | 2 | 96％ |
Result: in treatment group, in 90 routine patients, effective and healing accounts for 64 examples, accounts for 71%; 21 examples that take a turn for the better, account for 23%.Statistics total effective rate is 100%.
Below enumerate several model cases:
Case one: Dong, man, 40 years old, peasant, made a definite diagnosis depression, after drinking, emotion is particularly out of control, migratory pain is eaten for many years depressedly, eats multiple medicines effect not good, takes pharmaceutical capsules of the present invention, March transference cure;
Case two: Luo, female, 41 years old, secondary school teachers.Depressed, can't be happy, during sad melancholy, wish is cryyed, job enthusiasm interest declines, companion is insomnia impatiently, fatigue and weak, time have thoughts of suicide more than 1 year.Locality is taken antidepressant drug and is taken a turn for the better, and drug withdrawal recurs, and repeatedly shows effect 4 times.This takes antidepressant drug and within 2 weeks, has no improvement before examining.Take the embodiment of the present invention one formula, every day 2 times, each 30g, after one month, symptom alleviates, and continues to take 3 months symptoms and obviously improves, then take 2 months symptoms and disappear completely, and energy recovers, and is engaged in normal work.Follow up a case by regular visits to and within 4 months, have no recurrence.
Case three: grandson, female, 18 years old, student.Because of parental separation, mental pressure is excessive, makes a definite diagnosis depression, absentminded, and malaise, being happy and angry uncertainly, spiritlessness and weakness, eats depressedly, and multi-treatment effect is not good, carrys out my institute's diagnosis and treatment, takes pharmaceutical capsules of the present invention, thoroughly cures;
Case four; Lee, man is 27 years old, unemployed.After patient once suffered from the treatment of " depression " other places before 3 years, symptom took a turn for the better, and finished school smoothly.After graduating from university, never find regard work.Then engender depressedly, like sulkyly, occupied with nothing all day, short-tempered, accompany vexed bitter taste, inappetence, fatigue and weak, more than the February such as bradyphrenia, for several times, attempted suicide (taking poison) is once examined in autotomy.This takes the embodiment of the present invention four formulas, every day 2 times, and each 30g, after one month, symptom is improved, and emotion takes a turn for the better, and continues to take 4 months symptoms and thoroughly disappears.Follow up a case by regular visits to and have no recurrence half a year.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
A Chinese medicinal capsule for Cure of depression, according to parts by weight meter, formulated by following raw material of Chinese medicine: 10 parts of Herba Hyperici Monogynis, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 10 parts of Radix Curcumaes, 2 parts of Ganodermas, 5 parts, Poria, 2 parts of Caulis Bambusae In Taenia, 2 parts of Pericarpium Citri Reticulataes, 5 parts of Flos Albiziaes, 2 parts of Flos Lilii viridulies, 2 parts of Radix Rhodiolaes.
Embodiment 2:
A Chinese medicinal capsule for Cure of depression, according to parts by weight meter, formulated by following raw material of Chinese medicine: 15 parts of Herba Hyperici Monogynis, 15 parts of Radix Et Caulis Acanthopanacis Senticosis, 15 parts of Radix Curcumaes, 5 parts of Ganodermas, 7 parts, Poria, 5 parts of Caulis Bambusae In Taenia, 5 parts of Pericarpium Citri Reticulataes, 7 parts of Flos Albiziaes, 5 parts of Flos Lilii viridulies, 5 parts of Radix Rhodiolaes.
Embodiment 3:
A Chinese medicinal capsule for Cure of depression, according to parts by weight meter, formulated by following preferred raw material of Chinese medicine: 13 parts of Herba Hyperici Monogynis, 13 parts of Radix Et Caulis Acanthopanacis Senticosis, 13 parts of Radix Curcumaes, 3 parts of Ganodermas, 6 parts, Poria, 3 parts of Caulis Bambusae In Taenia, 3 parts of Pericarpium Citri Reticulataes, 6 parts of Flos Albiziaes, 3 parts of Flos Lilii viridulies, 3 parts of Radix Rhodiolaes.
Embodiment 4:
A preparation method for the Chinese medicinal capsule of Cure of depression, comprises the following steps:
1) by weighting raw materials in above-described embodiment 1, decoct with water twice, add 8 times of water gagings at every turn, decoct for the first time 2 hours, decoct for the second time 1 hour, merging filtrate, after filtration, is dried to fine powder;
2) by step 1) in fine powder add anhydrous grape Icing Sugar mix homogeneously;
3) above-mentioned mixed-powder is put into capsule filling machine and carry out filling, obtain the capsule of every 0.5-0.6 gram.
Claims (3)
1. the Chinese medicinal capsule of a Cure of depression, it is characterized in that according to parts by weight meter, formulated by following raw material of Chinese medicine: Herba Hyperici Monogyni 10-15 part, Radix Et Caulis Acanthopanacis Senticosi 10-15 part, Radix Curcumae 10-15 part, Ganoderma 2-5 part, Poria 5-7 part, Caulis Bambusae In Taenia 2-5 part, Pericarpium Citri Reticulatae 2-5 part, Flos Albiziae 5-7 part, Flos Lilii viriduli 2-5 part, Radix Rhodiolae 2-5 part.
2. the Chinese medicinal capsule of a kind of Cure of depression according to claim 1, it is characterized in that according to parts by weight meter, formulated by following raw material of Chinese medicine: 13 parts of Herba Hyperici Monogynis, 13 parts of Radix Et Caulis Acanthopanacis Senticosis, 13 parts of Radix Curcumaes, 3 parts of Ganodermas, 6 parts, Poria, 3 parts of Caulis Bambusae In Taenia, 3 parts of Pericarpium Citri Reticulataes, 6 parts of Flos Albiziaes, 3 parts of Flos Lilii viridulies, 3 parts of Radix Rhodiolaes.
3. a preparation method for the Chinese medicinal capsule of Cure of depression claimed in claim 1, is characterized in that comprising the following steps:
1) by above-mentioned weight ratio weighting raw materials, decoct with water twice, add 8 times of water gagings at every turn, decoct for the first time 2 hours, decoct for the second time 1 hour, merging filtrate, after filtration, is dried to fine powder;
2) by step 1) in fine powder add anhydrous grape Icing Sugar mix homogeneously;
3) above-mentioned mixed-powder is put into capsule filling machine and carry out filling, obtain the capsule of every 0.5-0.6 gram.
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| CN201410398203.0A CN104147518A (en) | 2014-08-13 | 2014-08-13 | Traditional Chinese medicinal capsule for treating depression and preparation method thereof |
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| CN104491687A (en) * | 2014-11-28 | 2015-04-08 | 李海鹰 | Traditional Chinese medicine capsules for treating depression and preparation method thereof |
| CN104587179A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Traditional Chinese medicine capsules for treating gingivitis and preparation method thereof |
| CN104587254A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Capsule for treating wind-heat type common cold and preparation method of capsule |
| CN110279797A (en) * | 2019-07-30 | 2019-09-27 | 济宁市中医院 | A kind of depression prevention and treatment Chinese medicine tea-drinking |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491687A (en) * | 2014-11-28 | 2015-04-08 | 李海鹰 | Traditional Chinese medicine capsules for treating depression and preparation method thereof |
| CN104587179A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Traditional Chinese medicine capsules for treating gingivitis and preparation method thereof |
| CN104587254A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Capsule for treating wind-heat type common cold and preparation method of capsule |
| CN110279797A (en) * | 2019-07-30 | 2019-09-27 | 济宁市中医院 | A kind of depression prevention and treatment Chinese medicine tea-drinking |
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Application publication date: 20141119 |