CN100336486C - Synchronous analyzer for detecting signal of blood stream from nystagmus image and ear ending - Google Patents

Abstract

The invention discloses a synchronous detection analyzer for nystagmus and ear peripheral blood flow signals, which can simultaneously acquire and analyze the signals of nystagmus and ear peripheral blood flow changes related to vertigo or not caused by vertigo. It is composed of a light shielding goggle (8), a low light source (11), a CCD sensor (9), a grating (10), an infrared emitting light source (4), an infrared light detector (2), a signal acquisition card, a computer, a display, Printer composition. The signals collected by the ear peripheral blood flow signal acquisition device and the nystagmus signal acquisition device are input to the computer through the signal acquisition card, and the output signals processed by the computer can be transmitted and exchanged with the upper computer, or displayed and printed. The invention can be used for non-invasive detection and synchronous collection of nystagmus and ear peripheral blood flow signals, thereby improving reliable judgment basis for clinical diagnosis and pharmacological analysis.

Description

Synchronous detection analyzer for nystagmus and ear peripheral blood flow signal

technical field

The invention relates to a synchronous detection analyzer for a nystagmus graph and an ear peripheral blood flow signal, capable of synchronously detecting the nystagmus graph and the ear peripheral blood flow signal.

Background technique

Usually, nystagmus is associated with various physiological changes, such as vertebrobasilar insufficiency, motion sickness, psychiatric disease, especially vertigo disease. Vertigo can not only cause nystagmus, but also cause autonomic dysfunction. Nervous dysfunction can cause peripheral ear blood vessels to constrict, resulting in pale complexion. Since the peripheral blood of the ear is transported by the blood vessels of the face, the pale face during vertigo is caused by insufficient blood supply to the peripheral ear, and the degree of insufficient blood supply to the peripheral ear is necessarily related to the degree of vertigo. Therefore, the degree of vertigo and the cause of vertigo can be analyzed by obtaining the information of the nystagmus and the change information of the peripheral blood flow of the ear.

Mechanism of vertigo: The normal spatial relationship means that all parts of the body are in the best balance against gravity, and it means that the body posture, stability and correct "balance triplet" play an important role in the balance adjustment of the body. Balanced Triad: Consists of static-dynamic system (vestibular-labyrinthine system), vision and proprioception (tactile and deep senses). Vision, proprioception, and vestibular sensory system are the basic organs for orientation perception. Visual experience can recognize the orientation of surrounding objects, as well as the relationship between itself and external objects. Due to the transmission of proprioception, people can always understand their own posture , position, and range and amplitude of movement; due to the sense of the vestibular organ, people can distinguish the direction of movement of the limbs, and judge that once the center of gravity of the body shifts and the movement of the limbs occurs, the balance will immediately change, so visual proprioception and vestibular balance The sensory organs of the senses immediately transmit the signals to the central nervous system, and integrate them in the brainstem reticular structure, so that the sensory impulses of the three are coordinated without conflict, and a normal orientation experience is produced. The sensory functions of the three parts have changed, which may cause vertigo.

The mechanism of vertigo: Under normal circumstances, the activity of the vestibular system is rarely perceived by people. When it is greatly stimulated and damaged, the vestibular organ and the proprioceptor from the muscles and joints respond inconsistently to the spatially oriented impulse, resulting in motion illusions, that is, vertigo. . The second situation is that when one side of the vestibular nerve is damaged, the afferent impulses on both sides are unbalanced and produce vertigo sensation in the cerebral cortex. In the third condition, vestibular-ocular reflex disorder, the vestibular nucleus communicates with the oculomotor, trochlear, and abducens nuclei via the medial longitudinal tract, and damage to this pathway results in nystagmus. The fourth situation is that the vestibulospinal nucleus connects with the cerebellum, red nucleus, and anterior horn cells of the spinal cord through the vestibulospinal tract to form a vestibulospinal pathway, and abnormal vestibular spinal cord reflexes cause balance disorders and ataxia. The fifth case is when the connection between the vestibular nucleus and the vasomotor center and vagus nucleus of the brainstem reticular structure is abnormal, and the vestibular nerve is dysfunctional. The sixth situation is that the vestibular semicircular canal is sensitive, and the afferent impulse causes a strong reaction during linear motion and rotational variable speed motion, resulting in postural adjustment disorders and dizziness. The seventh situation is that the fibers of the sympathetic nerves wound on the wall of the labyrinth are related to the movement of the blood vessels so as to affect the blood supply of the labyrinth (a syndrome of mental stress and anxiety).

The cause of vertigo: According to statistics, there are more than 80 kinds of causes of vertigo, some of which are clear, but 30% to 40% are still difficult to determine [Chen Xuetao, The cause of vertigo, clinical manifestations and classification, Chinese Journal of Rural Medicine, 2003, 10(3)]. Diagnosis of vertigo and differential diagnosis of symptoms The commonly used methods for medical examination of vertigo mainly include the following.

Fundus examination: check for papilledema, fundus blood vessels, and retina.

Neurootology examination: Examination of hearing, Eustachian tubes, semicircular canals, and otolith function.

Check biochemical indicators: hematocrit, blood viscosity, fibrinogen, red blood cell rigidity, platelet count, adhesion and aggregation, etc.

Imaging and physical examination: Inner ear labyrinth, ultra-high electron beam scan, color ultrasound scan, and Doppler flow analyzer to check intracranial arterial blood flow.

Electrophysiological examination: check audiometry, auditory evoked potential, electronystagmogram, etc. [Li Yingxi, Explanation of the clinical diagnosis and treatment process recommendations for vertigo, Chinese Journal of Neuropsychiatric Diseases, 2003, 29(4)].

The occurrence rate of nystagmus measured by nystagmography for vertigo due to vertebrobasilar insufficiency was 87% [Zhang Yongzhu et al., Significance of electronystagmography in diagnosing vertigo due to vertebrobasilar insufficiency, Chinese Clinical Rehabilitation, 2002, 21 (6) ].

There is also an inner ear temperature stimulation test: the inner ear temperature stimulation test is due to the uneven heating of the lymph fluid in the semicircular canals, which can cause dizziness and nystagmus.

Rotation experiment: It can cause the semicircular canal to produce a sense of rotation and nystagmus under the influence of inertia.

Position test: dizziness and nystagmus due to instantaneous dynamic changes of semicircular canal lymph fluid caused by different positions of the subject's head [Shi Jin, General diagnostic sequence of vertigo, Chinese Journal of Rural Medicine, 2003, 10(3)].

Guo Chunmiao and others used TCD to analyze 70 cases of vertigo, which provided a diagnostic basis for 57 cases of vertebral artery insufficiency. The French explorer-cvs detector was used to detect the anterior, middle and posterior cerebral arteries on the same side through the left and right temporal windows at different depths. And the basal bilateral vertebral artery and posterior inferior cerebellar artery were detected at different depths through the large occipital window, and the average blood flow velocity and vascular pulsation index of blood vessel contraction and relaxation were measured, and the blood flow velocity of vertigo was slowed down [Guo Chunmiao et al. People, TCD (Color Doppler) detection of VBI (vertebrobasilar insufficiency) vertigo diagnostic value, Chinese New Medicine, 2002, 3 (1)].

Through the analysis of the characteristics of nystagmus, it is also possible to distinguish the causes of different axial amplitudes of nystagmus. Meniere's disease nystagmus is a horizontal movement, and nystagmus in mental illness and other diseases has its own characteristics [Huang Wenjing et al., nystagmus Significance of observation in the care of patients with vertigo, Journal of Nursing Advancement, 2003, 18(3)].

The above studies have shown that nystagmus is closely related to vertigo. Nystagmus is also caused by a variety of diseases. Different nystagmus characteristics are caused by different reasons. Some nystagmus is not directly related to vertigo. Correct diagnosis is very important for treatment. The autonomic nerve dysfunction caused by vertigo causes peripheral vasoconstriction, which leads to peripheral ear vascular ischemia. It is a certain type of disease. The cause is not all nystagmus syndrome. The characteristics of nystagmus are combined with changes in ear peripheral vascular ischemia. It is of great significance to analyze the etiology of nystagmus and vertigo.

Although there are multiple methods for vertigo in the existing medical examinations, the causes of vertigo are usually analyzed clinically by various inspection methods to achieve the purpose of correct diagnosis. However, there is no report on a diagnostic instrument that obtains a mutually corroborated basis in one analytical instrument. Using one instrument can simultaneously detect the information of nystagmus and ear peripheral blood vessel ischemia changes at the same time and at the same place, which can avoid the time difference and environmental changes. interference.

Contents of the invention

In order to overcome the inadequacy of existing technologies that cannot simultaneously detect nystagmus and ischemic changes in peripheral ear vessels, the present invention provides a synchronous detection analyzer for nystagmus and peripheral ear blood flow signals, which can simultaneously detect nystagmus patterns and peripheral ear blood flow signals. blood flow signal.

The technical solution adopted by the present invention to solve the technical problem is: a synchronous detection and analysis instrument for nystagmus and peripheral blood flow signal of the ear, including a peripheral blood flow signal acquisition device, a nystagmus signal acquisition device, a signal acquisition card, a computer, The display and the printer are characterized in that the signals collected by the ear peripheral blood flow signal acquisition device and the nystagmus signal acquisition device are input to the computer through the signal acquisition card.

The ear peripheral blood flow signal acquisition device includes an infrared emitting light source 4 and an infrared light detector 2, and the infrared emitting light source 4 and the infrared light detector 2 are placed at a distance from the ear tissue 1 and face each other.

The nystagmus signal acquisition device includes a CCD sensor 9 , a grating 10 and a micro-light source 11 , the micro-light source 11 is installed at the bottom of the light shield 8 , and the grating 10 is installed between the micro-light source 11 and the CCD sensor 9 .

The grating 10 is installed horizontally.

The beneficial effects of the present invention are: since the ear peripheral blood flow signal acquisition device and the nystagmus signal acquisition device are electrically connected together with the signal acquisition card, non-invasive detection can be performed, and the nystagmus pattern and the ear peripheral blood flow signal can be detected synchronously , to improve a reliable judgment basis for clinical diagnosis and pharmacological analysis.

The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

Description of drawings

Fig. 1 is a front view of the usage mode of the ear peripheral blood flow signal acquisition device of the present invention;

Fig. 2 is a back view of the usage mode of the ear peripheral blood flow signal acquisition device of the present invention;

Fig. 3 is a positional view of the infrared emitter and the infrared light detector of the ear peripheral blood flow signal acquisition device of the present invention;

Fig. 4 is a view of the nystagmus signal acquisition device of the present invention;

Fig. 5 is a structural block diagram of the present invention;

Fig. 6 is a schematic diagram of grating positions of the nystagmus signal acquisition device of the present invention.

Detailed ways

According to the clinical symptoms of nystagmus caused by vertigo, and vegetative nerve dysfunction caused by vertigo, which leads to spasm of peripheral blood vessels on the face, insufficient blood supply to the end of the face, and insufficient blood supply to the end of the ear. The surface of the nystagmus forms a spot - when the nystagmus spot forms a jumping spot, the jumping spot uses a camera (CCD) to capture the image of the nystagmus, and uses a grating device to distinguish the horizontal amplitude of the nystagmus from the axis of the nystagmus. Vertical amplitude, or For disordered tremor, the grating device is a horizontal grid. When the nystagmus has a horizontal amplitude, the light spot jumps into a horizontal continuous wave map. When the nystagmus has a vertical amplitude, because the grating device is a horizontal grid, the spot jumping continuity is divided into horizontal grids. Breakpoint wave diagram, through CCD signal collection, computer processing to calculate the frequency and amplitude, to identify whether the nystagmus is a vertical amplitude or a horizontal amplitude. Peripheral blood filling is different from ear peripheral ischemia in the amount of infrared light absorption. Infrared detectors obtain change information, which is input to the computer, and the computer processes and calculates the change value of ear peripheral blood flow velocity and flow.

Refer to Figures 1-6. The 3600Hz modulation circuit composed of infrared emitting light source 4, infrared light detector 2 and wire 3 constitutes the ear peripheral blood flow signal acquisition device. The infrared emitting light is detected by the infrared detector through the ear tissue, and the infrared emitting light source 4 is modulated at 3600Hz. The ear tissue 1 is received by the infrared light detector 2. Since the blood flow of the peripheral blood vessels distributed in the ear tissue 1 is different, the light source absorbed by the ear tissue 1 is also different, and the light signal received by the infrared light detector 2 is absorbed by the light source. The signal output by the infrared light detector 2 also changes with the amount of absorption of the light source. The signal output by the infrared light detector 2 is output to the acquisition card through the wire 3 and then input to the computer. After computer processing, the output is displayed or printed. .

A nystagmus signal acquisition device is composed of a light shield 8, a microlight source 11, a CCD9 and a grating 10. The light shield 8 covers the eyeball 7 to avoid interfering with the light source. The bottom of the light shield 8 is equipped with a microlight source 11. A grating 10 is installed between the micro light source 11 and the CCD9, and the grating 10 is installed horizontally. When the light-shielding goggles 8 cover the eyeball 7, the eyeball 7 displays micro-spots. The eyeball 7 is coaxial with the optical path of the CCD9, and the micro-spots are captured by the CCD9. The captured micro-spot signals are collected by the signal acquisition card and input to the computer, and then processed and output by the computer. Display or print output.

The nystagmus ear peripheral blood flow signal is acquired at the same time and at the same place, avoiding the interference of time difference and location environment change. The signal obtained by synchronous detection of the nystagmus ear peripheral blood flow is of great significance for disease diagnosis and pharmacological experiment analysis.

Claims (4)

1. A synchronous detection analyzer for nystagmus and ear peripheral blood flow signals, comprising an ear peripheral blood flow signal acquisition device, a nystagmus signal acquisition device, a signal acquisition card, a computer, a display and a printer, characterized in that: ear peripheral blood The signals collected by the stream signal acquisition device and the nystagmus signal acquisition device are input to the computer through the signal acquisition card. 2. The nystagmus and ear peripheral blood flow signal synchronous detection analyzer according to claim 1, characterized in that: said ear peripheral blood flow signal acquisition device includes an infrared emitting light source (4) and an infrared light detector ( 2), the infrared emitting light source (4) and the infrared light detector (2) are spaced apart from the ear tissue (1) and face each other. 3. The nystagmus and ear peripheral blood flow signal synchronous detection analyzer according to claim 1, characterized in that: said nystagmus signal acquisition device includes a CCD sensor (9), a grating (10) and a microlight source ( 11), the micro-light source (11) is installed at the bottom of the light shielding goggle (8), and a grating (10) is installed between the micro-light source (11) and the CCD sensor (9). 4. The instrument for synchronous detection and analysis of nystagmus and ear peripheral blood flow signals according to claim 3, characterized in that the grating (10) is installed horizontally.

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