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CL2021000163A1 - Anticuerpos anti-htra1 y metodos de usos de los mismos. (divisional de solicitud 201801139) - Google Patents

Anticuerpos anti-htra1 y metodos de usos de los mismos. (divisional de solicitud 201801139)

Info

Publication number
CL2021000163A1
CL2021000163A1 CL2021000163A CL2021000163A CL2021000163A1 CL 2021000163 A1 CL2021000163 A1 CL 2021000163A1 CL 2021000163 A CL2021000163 A CL 2021000163A CL 2021000163 A CL2021000163 A CL 2021000163A CL 2021000163 A1 CL2021000163 A1 CL 2021000163A1
Authority
CL
Chile
Prior art keywords
methods
htra1
antibodies
application divisional
htra1 antibodies
Prior art date
Application number
CL2021000163A
Other languages
English (en)
Inventor
Wei-Ching Liang
Yan Wu
Robert F Kelley
Germaine Fuh
Daniel K Kirchhofer
Joyce Lai
Chingwei V Lee
Kelly M Loyet
Tao Sai
Lookeren Campagne Menno Van
Michael T Lipari
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CL2021000163A1 publication Critical patent/CL2021000163A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención proporciona anticuerpos anti-HtrA1 (que incluyen anticuerpos antiHtrA1 anti- Factor D biespecíficos) y métodos para elaborarlos y usarlos, por ejemplo, métodos para tratar trastornos asociados a HtrA1, trastornos oculares y/o trastornos asociados al complemento.
CL2021000163A 2015-10-30 2021-01-20 Anticuerpos anti-htra1 y metodos de usos de los mismos. (divisional de solicitud 201801139) CL2021000163A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562248871P 2015-10-30 2015-10-30
US201662345669P 2016-06-03 2016-06-03
US201662411113P 2016-10-21 2016-10-21

Publications (1)

Publication Number Publication Date
CL2021000163A1 true CL2021000163A1 (es) 2021-08-06

Family

ID=57256463

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2018001139A CL2018001139A1 (es) 2015-10-30 2018-04-27 Anticuerpos anti-htra1 y métodos de uso de los mismos.
CL2020002103A CL2020002103A1 (es) 2015-10-30 2020-08-14 Anticuerpos anti-htra1 y metodos de uso de los mismos. (divisional solicitud 201801139)
CL2021000163A CL2021000163A1 (es) 2015-10-30 2021-01-20 Anticuerpos anti-htra1 y metodos de usos de los mismos. (divisional de solicitud 201801139)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CL2018001139A CL2018001139A1 (es) 2015-10-30 2018-04-27 Anticuerpos anti-htra1 y métodos de uso de los mismos.
CL2020002103A CL2020002103A1 (es) 2015-10-30 2020-08-14 Anticuerpos anti-htra1 y metodos de uso de los mismos. (divisional solicitud 201801139)

Country Status (34)

Country Link
US (5) US10421821B2 (es)
EP (2) EP3922649B1 (es)
JP (2) JP6750010B2 (es)
KR (2) KR102440160B1 (es)
CN (2) CN108290957B (es)
AU (2) AU2016344399B2 (es)
BR (1) BR112018007703A2 (es)
CA (2) CA3088612C (es)
CL (3) CL2018001139A1 (es)
CO (1) CO2018005393A2 (es)
CR (1) CR20180296A (es)
DK (1) DK3368578T3 (es)
ES (1) ES2870141T3 (es)
HK (1) HK1256094A1 (es)
HR (1) HRP20210736T1 (es)
HU (1) HUE054093T2 (es)
IL (3) IL295097A (es)
LT (1) LT3368578T (es)
MA (1) MA43113B1 (es)
MX (2) MX395572B (es)
MY (1) MY196448A (es)
NZ (1) NZ741780A (es)
PE (1) PE20181009A1 (es)
PH (2) PH12022550450A1 (es)
PL (1) PL3368578T3 (es)
PT (1) PT3368578T (es)
RS (1) RS61871B1 (es)
RU (2) RU2021117293A (es)
SG (2) SG11201803356SA (es)
SI (1) SI3368578T1 (es)
TW (2) TW202229360A (es)
UA (1) UA123773C2 (es)
WO (1) WO2017075212A1 (es)
ZA (2) ZA201802382B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108290957B (zh) 2015-10-30 2022-06-17 豪夫迈·罗氏有限公司 抗-HtrA1抗体及其使用方法
CN115925962A (zh) * 2015-10-30 2023-04-07 豪夫迈·罗氏有限公司 铰链修饰的抗体片段和其制备方法
AU2016344133A1 (en) * 2015-10-30 2018-05-17 Genentech, Inc. Anti-Factor D antibody formulations
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
CN114685453A (zh) 2016-06-21 2022-07-01 奥瑞恩眼科有限责任公司 杂环脯氨酰胺衍生物
JP7060525B2 (ja) 2016-07-01 2022-04-26 エフ．ホフマン－ラ ロシュ アーゲー Ｈｔｒａ１の発現を調節するためのアンチセンスオリゴヌクレオチド
AU2018390167A1 (en) 2017-12-21 2020-06-11 F. Hoffmann-La Roche Ag Companion diagnostic for HTRA1 RNA antagonists
TW202039585A (zh) * 2018-11-16 2020-11-01 美商雙子治療公司 靶向htra1之基於抗體之療法及使用方法
JP2022538222A (ja) * 2019-06-26 2022-09-01 アムニクス ファーマシューティカルズ， インコーポレイテッド Ｅｇｆｒ抗原結合断片およびそれを含む組成物
WO2021183849A1 (en) 2020-03-13 2021-09-16 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
CN118339187A (zh) * 2021-12-31 2024-07-12 上海宏成药业有限公司 抗pd-1抗体及其用途
WO2024182318A2 (en) * 2023-02-28 2024-09-06 Kodiak Sciences Inc. Antibodies to htra1 and conjugates thereof

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AU2019204537A1 (en) 2019-07-18
IL258627B (en) 2022-06-01
RU2018119014A3 (es) 2019-12-02
KR102440160B1 (ko) 2022-09-02
PE20181009A1 (es) 2018-06-26
KR102162324B1 (ko) 2020-10-07
WO2017075212A1 (en) 2017-05-04
PH12018500887A1 (en) 2018-10-29
NZ741780A (en) 2019-11-29
CN115160439A (zh) 2022-10-11
JP2020099329A (ja) 2020-07-02
AU2016344399B2 (en) 2019-03-28
EP3922649B1 (en) 2024-01-17
PL3368578T3 (pl) 2021-07-26
SG11201803356SA (en) 2018-05-30
US20190375856A1 (en) 2019-12-12

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