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CL2020001062A1 - Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos. - Google Patents

Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos.

Info

Publication number
CL2020001062A1
CL2020001062A1 CL2020001062A CL2020001062A CL2020001062A1 CL 2020001062 A1 CL2020001062 A1 CL 2020001062A1 CL 2020001062 A CL2020001062 A CL 2020001062A CL 2020001062 A CL2020001062 A CL 2020001062A CL 2020001062 A1 CL2020001062 A1 CL 2020001062A1
Authority
CL
Chile
Prior art keywords
methods
sulfoxides
compounds
sulfones
bicyclic
Prior art date
Application number
CL2020001062A
Other languages
English (en)
Inventor
Huifen Chen
Snahel Patel
Gregory Hamilton
Craig Stivala
Blake Daniels
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2020001062A1 publication Critical patent/CL2020001062A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PROPORCIONAN COMPUESTOS QUE TIENEN LA FÓRMULA GENERAL I: EN LA QUE R1, R B1, RB2, N, P, Q, EL ANILLO A Y EL ANILLO B SON COMO SE DESCRIBEN EN EL PRESENTE DOCUMENTO, COMPOSICIONES FARMACÉUTICAS QUE INCLUYEN LOS COMPUESTOS Y MÉTODOS PARA USAR LOS COMPUESTOS. LOS COMPUESTOS DE FÓRMULA (I) SON INHIBIDORES DE LA QUINASA RIP1 Y, POR LO TANTO, SON ÚTILES EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS, NEURODEGENERATIVOS Y DE OTRO TIPO.
CL2020001062A 2017-10-31 2020-04-20 Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos. CL2020001062A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762579392P 2017-10-31 2017-10-31

Publications (1)

Publication Number Publication Date
CL2020001062A1 true CL2020001062A1 (es) 2020-08-21

Family

ID=64051580

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020001062A CL2020001062A1 (es) 2017-10-31 2020-04-20 Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos.

Country Status (21)

Country Link
US (2) US11072617B2 (es)
EP (1) EP3704097B1 (es)
JP (1) JP2021501183A (es)
KR (1) KR20200083515A (es)
CN (1) CN111278809B (es)
AR (1) AR113811A1 (es)
AU (1) AU2018360270A1 (es)
BR (1) BR112020008446A2 (es)
CA (1) CA3078688A1 (es)
CL (1) CL2020001062A1 (es)
CO (1) CO2020003475A2 (es)
CR (1) CR20200168A (es)
IL (1) IL273847A (es)
MA (1) MA50503A (es)
MX (1) MX2020003451A (es)
PE (1) PE20211247A1 (es)
PH (1) PH12020550537A1 (es)
RU (1) RU2020115915A (es)
SG (1) SG11202002877RA (es)
TW (1) TW201922748A (es)
WO (1) WO2019086494A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201831478A (zh) 2016-12-02 2018-09-01 瑞士商赫孚孟拉羅股份公司 雙環醯胺化合物及其使用方法
FI3652178T3 (fi) 2017-07-14 2024-03-19 Hoffmann La Roche Bisyklisiä ketoniyhdisteitä ja niiden käyttömenetelmiä
PE20211247A1 (es) 2017-10-31 2021-07-13 Hoffmann La Roche Sulfonas y sulfoxidos biciclicos y metodos de usos de los mismos
CN113302193A (zh) 2019-01-11 2021-08-24 豪夫迈·罗氏有限公司 双环吡咯并三唑酮化合物及其使用方法
TW202214617A (zh) 2020-06-02 2022-04-16 法商賽諾菲公司 作為ｒｉｐｋ１抑制劑之異㗁唑啶及其用途
US11897876B2 (en) 2021-11-11 2024-02-13 Genzyme Corporation Isoxazolidines as RIPK1 inhibitors and use thereof

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620508A1 (de) * 1965-07-23 1969-09-18 Thomae Gmbh Dr K Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3948903A (en) 1972-12-15 1976-04-06 Parke, Davis & Company Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
GB8610530D0 (en) * 1986-04-30 1986-06-04 Fbc Ltd Herbicides
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
US5112596A (en) 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
DE69328430T2 (de) 1992-07-27 2001-01-25 The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer Zielgerichte liposome zur blut-hirne schranke
US6080772A (en) 1995-06-07 2000-06-27 Sugen, Inc. Thiazole compounds and methods of modulating signal transduction
EP1007042A4 (en) * 1997-06-13 2001-07-04 Sugen Inc NEW HETEROCYCLIC COMPOUNDS FOR MODULATING THE PROTEIN-TYROSIN-ENZYME-RELATED CELLULAR SIGNAL TRANSDUCTION
JP2004502642A (ja) 2000-02-11 2004-01-29 ブリストル−マイヤーズ　スクイブ　カンパニー カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用
US6514221B2 (en) 2000-07-27 2003-02-04 Brigham And Women's Hospital, Inc. Blood-brain barrier opening
AU2001286930A1 (en) 2000-08-30 2002-03-13 The Board Of Trustees Of The Leland Stanford Junior University Glucocorticoid blocking agents for increasing blood-brain barrier permeability
US7034036B2 (en) 2000-10-30 2006-04-25 Pain Therapeutics, Inc. Inhibitors of ABC drug transporters at the blood-brain barrier
DE10121982B4 (de) 2001-05-05 2008-01-24 Lts Lohmann Therapie-Systeme Ag Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US20030162695A1 (en) 2002-02-27 2003-08-28 Schatzberg Alan F. Glucocorticoid blocking agents for increasing blood-brain barrier permeability
JP4494205B2 (ja) 2002-08-26 2010-06-30 武田薬品工業株式会社 カルシウム受容体調節化合物およびその用途
JP4995423B2 (ja) 2002-12-03 2012-08-08 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート 物質を血液−脳関門を渡って輸送するための人工低密度リポタンパク質キャリア
DE602004016992D1 (de) 2003-05-02 2008-11-20 Elan Pharm Inc 4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3-carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen
JP2007505142A (ja) 2003-09-10 2007-03-08 セダーズ−シナイ メディカル センター 血液脳関門を通過する薬剤のカリウムチャネル媒介性送達
EP2083009A1 (de) * 2008-01-22 2009-07-29 Grünenthal GmbH Substituierte Tethrahydroimidazopyridin-Verbindungen und deren Verwendung in Arzneimitteln
US8299077B2 (en) 2009-03-02 2012-10-30 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
CN101824036A (zh) 2009-03-05 2010-09-08 上海恒瑞医药有限公司 四氢咪唑并[1，5-a]吡嗪衍生物的盐,其制备方法及其在医药上的应用
BR112014010391A2 (pt) 2011-11-03 2017-04-18 Hoffmann La Roche composto, composição farmacêutica, processo de produção de uma composição farmacêutica, método de tratamento, kit e uso de uma composição farmacêutica
RU2014148732A (ru) 2012-05-22 2016-07-20 Ф. Хоффманн-Ля Рош Аг Замещенные дипиридиламины и их применение
KR101701663B1 (ko) 2013-01-18 2017-02-01 에프. 호프만-라 로슈 아게 3-치환된 피라졸 및 dlk 억제제로서의 용도
TWI648274B (zh) 2013-02-15 2019-01-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類 （二）
BR112015027381A8 (pt) 2013-05-01 2018-01-30 Hoffmann La Roche pirimidinas substituídas por heterocicloalquila ligadas ao c e seus usos
EA033084B1 (ru) 2013-05-01 2019-08-30 Ф.Хоффманн-Ля Рош Аг Бигетероарильные соединения и их применения
MX368728B (es) 2013-07-10 2019-10-14 Vertex Pharma Amidas de piperidina fusionadas como moduladores de canales de iones.
MX2016008110A (es) 2013-12-20 2016-08-19 Hoffmann La Roche Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos.
CA2935612A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
US20170266199A1 (en) 2014-08-21 2017-09-21 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as rip1 kinase inhibitors as medicaments
CN107406462B (zh) 2015-03-09 2020-11-10 豪夫迈·罗氏有限公司 三环dlk抑制剂及其用途
UY36680A (es) 2015-05-19 2016-12-30 Glaxosmithkline Ip Dev Ltd Amidas heterocíclicas como inhibidores de quinasa
MY192762A (en) 2015-07-02 2022-09-07 Hoffmann La Roche Bicyclic lactams and methods of use thereof
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CN108602809B (zh) 2015-12-04 2022-09-30 戴纳立制药公司 异噁唑烷衍生的受体相互作用蛋白激酶1(ripk 1)的抑制剂
US10961258B2 (en) 2015-12-21 2021-03-30 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
MA44007A (fr) * 2016-02-05 2018-12-19 Denali Therapeutics Inc Inhibiteurs du récepteur interagissant avec protéine kinase 1
IL266372B2 (en) 2016-11-08 2023-11-01 Cyclerion Therapeutics Inc Running SGC
TW201831478A (zh) 2016-12-02 2018-09-01 瑞士商赫孚孟拉羅股份公司 雙環醯胺化合物及其使用方法
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
FI3652178T3 (fi) 2017-07-14 2024-03-19 Hoffmann La Roche Bisyklisiä ketoniyhdisteitä ja niiden käyttömenetelmiä
KR20200070297A (ko) 2017-10-11 2020-06-17 에프. 호프만-라 로슈 아게 Rip1 키나아제 억제제로서 사용하기 위한 이환형 화합물
PE20211247A1 (es) 2017-10-31 2021-07-13 Hoffmann La Roche Sulfonas y sulfoxidos biciclicos y metodos de usos de los mismos

Also Published As

Publication number Publication date
RU2020115915A3 (es) 2022-05-06
AU2018360270A1 (en) 2020-03-26
BR112020008446A2 (pt) 2020-12-29
SG11202002877RA (en) 2020-04-29
JP2021501183A (ja) 2021-01-14
CN111278809A (zh) 2020-06-12
KR20200083515A (ko) 2020-07-08
US12338241B2 (en) 2025-06-24
CR20200168A (es) 2020-07-12
PE20211247A1 (es) 2021-07-13
TW201922748A (zh) 2019-06-16
PH12020550537A1 (en) 2021-03-22
US20230002391A1 (en) 2023-01-05
AR113811A1 (es) 2020-06-10
MA50503A (fr) 2020-09-09
EP3704097B1 (en) 2023-10-25
IL273847A (en) 2020-05-31
CO2020003475A2 (es) 2020-04-24
US20190127382A1 (en) 2019-05-02
RU2020115915A (ru) 2021-12-01
CN111278809B (zh) 2024-06-25
EP3704097C0 (en) 2023-10-25
US11072617B2 (en) 2021-07-27
EP3704097A1 (en) 2020-09-09
MX2020003451A (es) 2020-08-03
CA3078688A1 (en) 2019-05-09
WO2019086494A1 (en) 2019-05-09

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