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CL2019002464A1 - Formas cristalinas del derivado de 4-pirimidinsulfamida de aprocitentán. - Google Patents

Formas cristalinas del derivado de 4-pirimidinsulfamida de aprocitentán.

Info

Publication number
CL2019002464A1
CL2019002464A1 CL2019002464A CL2019002464A CL2019002464A1 CL 2019002464 A1 CL2019002464 A1 CL 2019002464A1 CL 2019002464 A CL2019002464 A CL 2019002464A CL 2019002464 A CL2019002464 A CL 2019002464A CL 2019002464 A1 CL2019002464 A1 CL 2019002464A1
Authority
CL
Chile
Prior art keywords
crystalline forms
pyrimidin
bromo
procytentan
iloxi
Prior art date
Application number
CL2019002464A
Other languages
English (en)
Inventor
Martin Bolli
Philipp Kohler
Ivan Schindelholz
Raumer Markus Von
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of CL2019002464A1 publication Critical patent/CL2019002464A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physiology (AREA)
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Abstract

LA PRESENTE INVENCIÓN SE REFIERE A FORMAS CRISTALINAS NOVEDOSAS DE {5-(4-BROMO-FENIL)-6-[2-(5- BROMO-PIRIMIDIN-2-ILOXI)-ETOXI]-PIRIMIDIN-4-IL}-SULFAMIDA, PROCEDIMIENTOS PARA LA PREPARACIÓN DE LAS MISMAS, COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHAS FORMAS CRISTALINAS, COMPOSICIONES FARMACÉUTICAS PREPARADAS A PARTIR DE TALES FORMAS CRISTALINAS Y SU USO COMO ANTAGONISTAS DEL RECEPTOR DE ENDOTELINA. TAMBIÉN SE REFIERE A USOS NUEVOS DE LA {5-(4-BROMO-FENIL)-6-[2-(5-BROMOPIRIMIDIN-2-ILOXI)-ETOXI]-PIRIMIDIN-4-IL}-SULFAMIDA, YA SEA SOLA O EN COMBINACIÓN CON OTROS INGREDIENTES ACTIVOS O AGENTES TERAPÉUTICOS.
CL2019002464A 2017-02-27 2019-08-27 Formas cristalinas del derivado de 4-pirimidinsulfamida de aprocitentán. CL2019002464A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017054489 2017-02-27
EP2017061487 2017-05-12

Publications (1)

Publication Number Publication Date
CL2019002464A1 true CL2019002464A1 (es) 2020-01-31

Family

ID=60268369

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2019002464A CL2019002464A1 (es) 2017-02-27 2019-08-27 Formas cristalinas del derivado de 4-pirimidinsulfamida de aprocitentán.
CL2019002470A CL2019002470A1 (es) 2017-02-27 2019-08-27 Combinaciones de un derivado de 4-pirimidinsulfamida con ingredientes activos para el tratamiento de enfermedades relacionadas con endotelina.
CL2020001762A CL2020001762A1 (es) 2017-02-27 2020-06-30 Formas cristalinas del derivado de 4-pirimidinsulfamida de aprocitentán. (divisional solicitud 201902464)

Family Applications After (2)

Application Number Title Priority Date Filing Date
CL2019002470A CL2019002470A1 (es) 2017-02-27 2019-08-27 Combinaciones de un derivado de 4-pirimidinsulfamida con ingredientes activos para el tratamiento de enfermedades relacionadas con endotelina.
CL2020001762A CL2020001762A1 (es) 2017-02-27 2020-06-30 Formas cristalinas del derivado de 4-pirimidinsulfamida de aprocitentán. (divisional solicitud 201902464)

Country Status (28)

Country Link
US (5) US11174247B2 (es)
EP (3) EP3658140A1 (es)
JP (3) JP7223701B2 (es)
KR (3) KR102568472B1 (es)
CN (3) CN110325186A (es)
AU (2) AU2017400276B2 (es)
BR (2) BR112019017658A2 (es)
CA (2) CA3053991A1 (es)
CL (3) CL2019002464A1 (es)
DK (1) DK4014976T3 (es)
ES (1) ES3006308T3 (es)
FI (1) FI4014976T3 (es)
HR (1) HRP20241461T1 (es)
HU (1) HUE069231T2 (es)
IL (4) IL268850B2 (es)
LT (1) LT4014976T (es)
MA (2) MA49664A (es)
MX (3) MX2019010222A (es)
MY (1) MY199557A (es)
PH (2) PH12019501938A1 (es)
PL (1) PL4014976T3 (es)
PT (1) PT4014976T (es)
RS (1) RS66200B1 (es)
SG (3) SG11201907435PA (es)
SI (1) SI4014976T1 (es)
TW (2) TWI786089B (es)
UA (1) UA126122C2 (es)
WO (2) WO2018153513A1 (es)

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EP4153574A1 (en) 2020-05-21 2023-03-29 Teva Pharmaceuticals International GmbH Solid state forms of aprocitentan and process for preparation thereof
BR112023000406A2 (pt) 2020-07-10 2023-01-31 Astrazeneca Ab Combinação de zibotentan e dapagliflozina
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IL317076A (en) 2022-05-22 2025-01-01 Idorsia Pharmaceuticals Ltd Aprociten for the treatment of hypertension
CN119255985A (zh) 2022-05-25 2025-01-03 爱杜西亚药品有限公司 (5-(4-溴苯基)-6-(2-((5-溴嘧啶-2-基)氧基)乙氧基)嘧啶-4-基)(氨磺酰基)酰胺钠的结晶形式
WO2024140425A1 (zh) * 2022-12-30 2024-07-04 苏州科睿思制药有限公司 一种阿普昔腾坦晶型及其制备方法和用途

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