[go: up one dir, main page]

CL2017001459A1 - Biarilo compuestos útiles para el tratamiento de enfermedades humanas en oncología, neurología e inmunología - Google Patents

Biarilo compuestos útiles para el tratamiento de enfermedades humanas en oncología, neurología e inmunología

Info

Publication number
CL2017001459A1
CL2017001459A1 CL2017001459A CL2017001459A CL2017001459A1 CL 2017001459 A1 CL2017001459 A1 CL 2017001459A1 CL 2017001459 A CL2017001459 A CL 2017001459A CL 2017001459 A CL2017001459 A CL 2017001459A CL 2017001459 A1 CL2017001459 A1 CL 2017001459A1
Authority
CL
Chile
Prior art keywords
neurology
oncology
immunology
treatment
compounds useful
Prior art date
Application number
CL2017001459A
Other languages
English (en)
Inventor
T Hopkins Brian
Ma Bin
Raymond Chan Timothy
Sun Lihong
Zhang Lei
Kumaravel Gnanasambandam
P Lyssikatos Joseph
Koch Kevin
Miao Hua
Original Assignee
Sunesis Pharmaceuticals Inc
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc, Biogen Ma Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of CL2017001459A1 publication Critical patent/CL2017001459A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

<p>La presente invención proporciona compuestos y composiciones de estos que son útiles como inhibidores de Ia tirosina cinasa de Bruton y que presentan caracterIsticas deseables para estos.</p>
CL2017001459A 2013-12-11 2017-06-08 Biarilo compuestos útiles para el tratamiento de enfermedades humanas en oncología, neurología e inmunología CL2017001459A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361914886P 2013-12-11 2013-12-11

Publications (1)

Publication Number Publication Date
CL2017001459A1 true CL2017001459A1 (es) 2018-03-23

Family

ID=52302344

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2016001435A CL2016001435A1 (es) 2013-12-11 2016-06-10 Biarilo compuestos útiles para el tratamiento de enfermedades humanas en oncologia, neurología e inmunología
CL2017001459A CL2017001459A1 (es) 2013-12-11 2017-06-08 Biarilo compuestos útiles para el tratamiento de enfermedades humanas en oncología, neurología e inmunología

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2016001435A CL2016001435A1 (es) 2013-12-11 2016-06-10 Biarilo compuestos útiles para el tratamiento de enfermedades humanas en oncologia, neurología e inmunología

Country Status (32)

Country Link
US (4) US9809577B2 (es)
EP (3) EP3872075A1 (es)
JP (4) JP6431914B2 (es)
KR (1) KR102413253B1 (es)
CN (3) CN108947913A (es)
AR (2) AR098721A1 (es)
AU (2) AU2014362231B2 (es)
BR (1) BR112016012860A2 (es)
CA (1) CA2932608C (es)
CL (2) CL2016001435A1 (es)
CY (1) CY1120517T1 (es)
DK (1) DK3080103T3 (es)
EA (2) EA030538B1 (es)
ES (1) ES2678021T3 (es)
HR (1) HRP20181109T1 (es)
HU (1) HUE040346T2 (es)
IL (2) IL246031B (es)
LT (1) LT3080103T (es)
MX (2) MX370103B (es)
MY (1) MY179781A (es)
NZ (1) NZ721217A (es)
PH (1) PH12016501107B1 (es)
PL (1) PL3080103T3 (es)
PT (1) PT3080103T (es)
RS (1) RS57662B1 (es)
SA (1) SA518391170B1 (es)
SG (2) SG10201908558WA (es)
SI (1) SI3080103T1 (es)
SM (1) SMT201800373T1 (es)
TW (3) TWI675833B (es)
WO (1) WO2015089337A1 (es)
ZA (1) ZA201706244B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102711473B (zh) * 2009-09-04 2016-11-09 比奥根Ma公司 布鲁顿酪氨酸激酶抑制剂
AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
RS57662B1 (sr) 2013-12-11 2018-11-30 Biogen Ma Inc Biaril jedinjenja korisna za lečenje humanih bolesti u onkologiji, neurologiji i imunologiji
EP3307731A1 (en) * 2015-06-10 2018-04-18 Biogen MA Inc. Adipate forms and compositions of biaryl inhibitors of bruton's tyrosine kinase
WO2016201280A1 (en) 2015-06-10 2016-12-15 Biogen Ma Inc. Forms and compositions of biaryl inhibitors of bruton's tyrosine kinase
KR102214225B1 (ko) * 2015-12-07 2021-02-10 쑤저우 시노벤트 파마슈티칼즈 씨오., 엘티디. 5원 헤테로시클릭 아미드계 wnt 경로 억제제
JO3794B1 (ar) * 2015-12-10 2021-01-31 Janssen Pharmaceutica Nv المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون
JO3793B1 (ar) * 2015-12-10 2021-01-31 Janssen Pharmaceutica Nv مثبطات تيروزين كاينيز بروتون وأساليب استخدامها
EP3436572A4 (en) * 2016-03-31 2019-11-20 Lion TCR Pte. Ltd. EXOGENOUS VIRUS-SPECIFIC T-CELL RECEPTOR (TCR) EXPRESSIVE UNACTIVATED T-CELLS
JP2019520382A (ja) 2016-06-27 2019-07-18 杭州雷索薬業有限公司Ｈａｎｇｚｈｏｕ Ｒｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ ベンゾフランピラゾールアミン類プロテインキナーゼ阻害薬
BR112019001158A2 (pt) 2016-07-21 2019-04-30 Biogen Ma, Inc. formas de succinato e composições de inibidores da tirosina quinase de bruton
JP7076741B2 (ja) 2016-12-27 2022-05-30 国立研究開発法人理化学研究所 Ｂｍｐシグナル阻害化合物
JOP20190233A1 (ar) * 2017-04-14 2019-10-02 Biogen Ma Inc نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون
CN112262137A (zh) 2018-01-10 2021-01-22 阿林齐生物制药公司 四氢异喹啉化合物
EP3740481B9 (en) 2018-01-19 2024-10-23 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
US20190330226A1 (en) * 2018-04-26 2019-10-31 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1
AR115085A1 (es) * 2018-05-14 2020-11-25 Biogen Ma Inc DERIVADOS DE 3-AMINO-2,4,6-TRIAZINA COMO INHIBIDORES DE LA TIROSINA CINASA DE BRUTON (Btk)
WO2020005888A1 (en) 2018-06-26 2020-01-02 Cytokinetics, Inc. Cardiac sarcomere inhibitors
EP3814342B1 (en) 2018-06-26 2022-07-27 Cytokinetics, Inc. Cardiac sarcomere inhibitors
KR102653681B1 (ko) 2018-07-31 2024-04-03 록쏘 온콜로지, 인코포레이티드 (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제
MA53914A (fr) * 2018-10-15 2021-08-25 Biogen Ma Inc Polymorphes cristallins d'inhibiteurs de la tyrosine kinase de bruton
WO2020118683A1 (en) * 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
JP2022532235A (ja) 2019-05-15 2022-07-13 バイオジェン・エムエイ・インコーポレイテッド ブルトン型チロシンキナーゼの阻害剤
CN110627775A (zh) * 2019-10-24 2019-12-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
WO2021133894A1 (en) 2019-12-23 2021-07-01 Biogen Ma Inc. Btk inhibitors
JP2023537065A (ja) 2020-08-07 2023-08-30 バイオジェン・エムエイ・インコーポレイテッド Ｂｔｋ阻害剤
US20240216330A1 (en) 2021-04-02 2024-07-04 Biogen Ma Inc. Combination treatment methods of multiple sclerosis
JP2024525181A (ja) * 2021-06-21 2024-07-10 ベイジーン スウィッツァーランド ゲーエムベーハー （ｒ）－グルタルイミドｃｒｂｎリガンド及び使用方法
JP2025501082A (ja) * 2021-12-30 2025-01-17 ベイジーン スウィッツァーランド ゲーエムベーハー ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤をｅ３リガーゼリガンドにコンジュゲートすることによるｂｔｋの分解及び使用方法
WO2024146923A1 (en) 2023-01-04 2024-07-11 Ab Science Tubulin polymerization inhibitors
CN117088851A (zh) * 2023-07-13 2023-11-21 特科罗生物科技(成都)有限公司 一种嘧啶胺类nuak抑制剂及其制备方法和用途

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US833429A (en) * 1902-07-31 1906-10-16 Anthony Van Wagenen Automatic system of intercommunication.
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
ATE141502T1 (de) 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
GB9924862D0 (en) * 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
EP1313713B1 (en) * 2000-08-08 2008-06-11 Ortho-McNeil Pharmaceutical, Inc. 4-pyrimidinamine derivatives, pharmaceutical compositions and related methods
US20050014753A1 (en) 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
GB0325031D0 (en) * 2003-10-27 2003-12-03 Novartis Ag Organic compounds
JP2007519754A (ja) * 2004-01-30 2007-07-19 スミスクライン ビーチャム コーポレーション 化合物
US20060178388A1 (en) * 2005-02-04 2006-08-10 Wrobleski Stephen T Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
UA109411C2 (uk) * 2005-11-01 2015-08-25 N-трет-бутил-3-(2-хлор-5-метилпіримідин-4-іламіно)бензолсульфонамід та його застосування в способі одержання сполуки
MX362412B (es) * 2005-11-01 2019-01-15 Targegen Inc Inhibidores de biaril meta-pirimidina de cinasas.
EP1979329A2 (en) * 2006-01-30 2008-10-15 Exelixis, Inc. 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and methods of use
AR063946A1 (es) * 2006-09-11 2009-03-04 Cgi Pharmaceuticals Inc Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
NZ576705A (en) * 2006-11-01 2011-12-22 Chroma Therapeutics Ltd IKK-Beta SERINE-THREONINE PROTEIN KINASE INHIBITORS
CN101730699A (zh) * 2007-03-21 2010-06-09 百时美施贵宝公司 可用于治疗增殖性、变应性、自身免疫性和炎症性疾病的稠合杂环化合物
US8809273B2 (en) * 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
CN101889015B (zh) * 2007-10-05 2014-06-04 维拉斯通股份有限公司 嘧啶取代的嘌呤衍生物
ES2548141T3 (es) * 2008-11-20 2015-10-14 Glaxosmithkline Llc Compuestos químicos
CN102711473B (zh) * 2009-09-04 2016-11-09 比奥根Ma公司 布鲁顿酪氨酸激酶抑制剂
EP2485589A4 (en) * 2009-09-04 2013-02-06 Biogen Idec Inc HETEROARYL-BTK INHIBITORS
US8334292B1 (en) * 2010-06-14 2012-12-18 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
EP2638018A1 (en) 2010-11-09 2013-09-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
EP2548622B1 (en) 2011-03-31 2015-06-17 Mizuno Corporation Iron golf club head and iron golf club
EP2696683A4 (en) 2011-04-12 2014-08-13 Alzheimer S Inst Of America Inc COMPOSITIONS AND THERAPEUTIC APPLICATIONS OF IKK-MEDIATED KINASE EPSILON AND TANK BINDING KINASE-1 HEMMER
AR091273A1 (es) * 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
EP3444251B1 (en) 2013-12-11 2023-06-07 Biogen MA Inc. Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
RS57662B1 (sr) 2013-12-11 2018-11-30 Biogen Ma Inc Biaril jedinjenja korisna za lečenje humanih bolesti u onkologiji, neurologiji i imunologiji
AU2015268962A1 (en) * 2014-06-04 2017-01-12 Thomas Helledays Stiftelse For Medicinsk Forskning MTH1 inhibitors for treatment of inflammatory and autoimmune conditions
AR102177A1 (es) * 2014-10-06 2017-02-08 Merck Patent Gmbh Compuestos de heteroarilo como inhibidores de btk y usos de los mismos
WO2016201280A1 (en) 2015-06-10 2016-12-15 Biogen Ma Inc. Forms and compositions of biaryl inhibitors of bruton's tyrosine kinase
JOP20190233A1 (ar) 2017-04-14 2019-10-02 Biogen Ma Inc نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون

Also Published As

Publication number Publication date
MX2019014228A (es) 2020-01-23
US10081619B2 (en) 2018-09-25
JP2016539996A (ja) 2016-12-22
TWI675833B (zh) 2019-11-01
IL246031A0 (en) 2016-08-02
AU2019201997B2 (en) 2020-09-17
AU2014362231B2 (en) 2019-04-04
JP2021091733A (ja) 2021-06-17
EP3357921A2 (en) 2018-08-08
JP6526167B2 (ja) 2019-06-05
JP2019163280A (ja) 2019-09-26
CN109096274B (zh) 2022-07-01
CY1120517T1 (el) 2019-07-10
SMT201800373T1 (it) 2018-09-13
TW201811772A (zh) 2018-04-01
CN106459002B (zh) 2018-08-21
LT3080103T (lt) 2018-08-10
TWI608002B (zh) 2017-12-11
IL269569B (en) 2021-03-25
TW202017931A (zh) 2020-05-16
SI3080103T1 (sl) 2018-11-30
NZ721217A (en) 2021-12-24
PH12016501107A1 (en) 2016-07-11
EA201691114A1 (ru) 2016-11-30
CA2932608C (en) 2023-02-14
SG10201908558WA (en) 2019-10-30
JP2018035201A (ja) 2018-03-08
EP3080103A1 (en) 2016-10-19
EP3872075A1 (en) 2021-09-01
PH12016501107B1 (en) 2021-07-21
TW201536765A (zh) 2015-10-01
CN109096274A (zh) 2018-12-28
RS57662B1 (sr) 2018-11-30
US10759783B2 (en) 2020-09-01
ES2678021T3 (es) 2018-08-08
SA518391170B1 (ar) 2022-08-25
MY179781A (en) 2020-11-13
EP3080103B1 (en) 2018-04-18
AR098721A1 (es) 2016-06-08
AU2019201997C1 (en) 2021-03-18
SG11201604595VA (en) 2016-07-28
TWI744672B (zh) 2021-11-01
US20220332705A1 (en) 2022-10-20
AU2014362231A1 (en) 2016-07-07
US9809577B2 (en) 2017-11-07
MX370103B (es) 2019-12-02
CL2016001435A1 (es) 2017-06-09
EA030538B1 (ru) 2018-08-31
US20180093973A1 (en) 2018-04-05
US20190218204A1 (en) 2019-07-18
MX388978B (es) 2025-03-20
AU2019201997A1 (en) 2019-04-18
KR102413253B1 (ko) 2022-06-27
EP3357921A3 (en) 2018-09-12
MX2016007611A (es) 2016-09-09
JP7076022B2 (ja) 2022-05-26
JP6431914B2 (ja) 2018-11-28
ZA201706244B (en) 2019-04-24
DK3080103T3 (en) 2018-07-30
CN108947913A (zh) 2018-12-07
BR112016012860A2 (pt) 2017-08-08
WO2015089337A1 (en) 2015-06-18
US11572356B2 (en) 2023-02-07
EA037942B1 (ru) 2021-06-10
HUE040346T2 (hu) 2019-03-28
IL246031B (en) 2019-10-31
AR110381A2 (es) 2019-03-20
US20160311802A1 (en) 2016-10-27
KR20160106072A (ko) 2016-09-09
EP3080103B9 (en) 2018-09-19
CN106459002A (zh) 2017-02-22
HRP20181109T1 (hr) 2018-11-02
PT3080103T (pt) 2018-07-23
CA2932608A1 (en) 2015-06-18
PL3080103T3 (pl) 2018-10-31
IL269569A (en) 2019-11-28
EA201792348A1 (ru) 2018-09-28

Similar Documents

Publication Publication Date Title
CL2017001459A1 (es) Biarilo compuestos útiles para el tratamiento de enfermedades humanas en oncología, neurología e inmunología
JOP20200192A1 (ar) أجسام مضادة لـ tigit
UY37134A (es) Compuestos heteroarilos y composiciones que los contienen útiles como inhibidores de pad4
MX2022009148A (es) Composiciones y metodos para el tratamiento de hemoglobinopatias.
CL2017002122A1 (es) Heterociclos bicíclicos como inhibidores de fgfr4
CY1120035T1 (el) Πυριμιδοπυριμιδινονες χρησιμες ως αναστολεις της wee-1 κινασης
UY37018A (es) Inhibidores bicíclicos de pad4
CL2017001204A1 (es) Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa
ECSP17064695A (es) Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8
UY35500A (es) Indazoles sustituidos con heteroarilo
PT3119762T (pt) Derivados de benzimidazole como inibidores de tirosina quinase erbb para o tratamento do cancro
PH12016500330B1 (en) Certain chemical entities, compositions, and methods
CR20150255A (es) Derivados triciclicos fusionados de tiofeno como inhibidores de jak
NI201600071A (es) Compuestos de inhibidor de autotaxina
MX384490B (es) Agentes que inducen apoptosis para el tratamiento de cancer y enfermedades inmunitarias y autoinmunitarias.
EA201790273A1 (ru) Флагеллиновые композиции и их применение
UY37017A (es) Inhibidores aza-bencimidazol de pad4
UY36175A (es) 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas
CO2017007121A2 (es) Compuestos bicíclicos fusionados para el tratamiento de enfermedades
UY35499A (es) Indazoles sustituidos con diaminoheteroarilo
BR112015023074A2 (pt) agentes de ligação-met e uso dos mesmos
UY37980A (es) Compuestos novedosos para tratar enfermedades parasitarias
NI201600070A (es) Inhibidores tetracíclicos de autotaxina
CO2018008249A2 (es) Composiciones terapéuticas y métodos para el tratamiento de la hepatitis b
MX2015009277A (es) Formas de dosificacion y usos terapauticos de l-4-cloro quinurenina.