CL2015000255A1 - Compuestos heterociclicos derivados de alcoxipirazoles, activadores de guanilato ciclasa soluble; composicion farmaceutica que los comprende; uso para tratar enfermedad cardiovascular, enfermedad renal, hiperplasia benigna de prostata, disfuncion erectil, enfermedad de alzheimer, enfermedad de parkinson, entre otras. - Google Patents
Compuestos heterociclicos derivados de alcoxipirazoles, activadores de guanilato ciclasa soluble; composicion farmaceutica que los comprende; uso para tratar enfermedad cardiovascular, enfermedad renal, hiperplasia benigna de prostata, disfuncion erectil, enfermedad de alzheimer, enfermedad de parkinson, entre otras.Info
- Publication number
- CL2015000255A1 CL2015000255A1 CL2015000255A CL2015000255A CL2015000255A1 CL 2015000255 A1 CL2015000255 A1 CL 2015000255A1 CL 2015000255 A CL2015000255 A CL 2015000255A CL 2015000255 A CL2015000255 A CL 2015000255A CL 2015000255 A1 CL2015000255 A1 CL 2015000255A1
- Authority
- CL
- Chile
- Prior art keywords
- disease
- alkoxypyrazoles
- parkinson
- alzheimer
- pharmaceutical composition
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 208000010228 Erectile Dysfunction Diseases 0.000 title 1
- 208000018737 Parkinson disease Diseases 0.000 title 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 title 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 title 1
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 title 1
- 239000003119 guanylate cyclase activator Substances 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 201000001881 impotence Diseases 0.000 title 1
- 208000017169 kidney disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
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- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261697899P | 2012-09-07 | 2012-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2015000255A1 true CL2015000255A1 (es) | 2015-05-29 |
Family
ID=49170904
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015000255A CL2015000255A1 (es) | 2012-09-07 | 2015-02-03 | Compuestos heterociclicos derivados de alcoxipirazoles, activadores de guanilato ciclasa soluble; composicion farmaceutica que los comprende; uso para tratar enfermedad cardiovascular, enfermedad renal, hiperplasia benigna de prostata, disfuncion erectil, enfermedad de alzheimer, enfermedad de parkinson, entre otras. |
| CL2015000562A CL2015000562A1 (es) | 2012-09-07 | 2015-03-06 | Método para generar planta que contiene un polinucléotido de interés a partir de un protoplasto, que comprende aislar de una población de protoplastos, al menos uno que contiene el polinucleótido de interés y un marcador fluorescente, utilizando citometría de flujo activada por fluorescencia (facs); método de producción de semilla; y planta. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| CL2015000562A CL2015000562A1 (es) | 2012-09-07 | 2015-03-06 | Método para generar planta que contiene un polinucléotido de interés a partir de un protoplasto, que comprende aislar de una población de protoplastos, al menos uno que contiene el polinucleótido de interés y un marcador fluorescente, utilizando citometría de flujo activada por fluorescencia (facs); método de producción de semilla; y planta. |
Country Status (38)
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| EP (1) | EP2892891B1 (es) |
| JP (1) | JP5970134B2 (es) |
| KR (1) | KR101692707B1 (es) |
| CN (1) | CN104619695B (es) |
| AP (1) | AP2015008231A0 (es) |
| AR (1) | AR092869A1 (es) |
| AU (1) | AU2013312931B2 (es) |
| BR (1) | BR112015004529B1 (es) |
| CA (1) | CA2880494C (es) |
| CL (2) | CL2015000255A1 (es) |
| CY (1) | CY1122610T1 (es) |
| DK (1) | DK2892891T3 (es) |
| EA (1) | EA027244B1 (es) |
| EC (1) | ECSP15012804A (es) |
| ES (1) | ES2748798T3 (es) |
| GE (1) | GEP20176631B (es) |
| HK (1) | HK1210164A1 (es) |
| HR (1) | HRP20191755T1 (es) |
| HU (1) | HUE046996T2 (es) |
| IL (1) | IL236987A (es) |
| LT (1) | LT2892891T (es) |
| MA (1) | MA37891B1 (es) |
| MD (1) | MD4425C1 (es) |
| MX (1) | MX338887B (es) |
| NZ (1) | NZ703989A (es) |
| PE (1) | PE20151001A1 (es) |
| PH (1) | PH12015500457B1 (es) |
| PL (1) | PL2892891T3 (es) |
| PT (1) | PT2892891T (es) |
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| SG (2) | SG11201500861QA (es) |
| SI (1) | SI2892891T1 (es) |
| TN (1) | TN2015000054A1 (es) |
| TW (1) | TWI586661B (es) |
| UA (1) | UA115881C2 (es) |
| UY (1) | UY35012A (es) |
| WO (1) | WO2014039434A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| SG11201500861QA (en) * | 2012-09-07 | 2015-04-29 | Boehringer Ingelheim Int | Alkoxy pyrazoles as soluble guanylate cyclase activators |
| TW201625584A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
| US9353090B2 (en) * | 2014-07-22 | 2016-05-31 | Boehringer Ingelheim International Gmbh | Heterocyclic carboxylic acids as activators of soluble guanylate cyclase |
| JP2018537488A (ja) | 2015-12-18 | 2018-12-20 | ノバルティス アーゲー | インダン誘導体、ならびに可溶性グアニル酸シクラーゼ活性化剤としてのその使用 |
| WO2018069148A1 (de) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
| WO2019211081A1 (en) | 2018-04-30 | 2019-11-07 | Bayer Aktiengesellschaft | The use of sgc activators and sgc stimulators for the treatment of cognitive impairment |
| EA202092680A1 (ru) | 2018-05-15 | 2021-04-13 | Байер Акциенгезельшафт | 1,3-тиазол-2-ил-замещенные бензамиды для лечения заболеваний, ассоциированных с сенситизацией нервных волокон |
| US11508483B2 (en) | 2018-05-30 | 2022-11-22 | Adverio Pharma Gmbh | Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group |
| EA202190193A1 (ru) | 2018-07-12 | 2021-06-16 | Бёрингер Ингельхайм Интернациональ Гмбх | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы |
| US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
| CN112079712B (zh) * | 2020-09-18 | 2022-12-13 | 江苏美迪克化学品有限公司 | 一种对乙烯基水杨酸的制备方法 |
| EP4011873A1 (en) | 2020-12-10 | 2022-06-15 | Bayer Aktiengesellschaft | Substituted pyrazolo piperidine carboxylic acids |
| GB202102895D0 (en) | 2021-03-01 | 2021-04-14 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| CN118900690A (zh) * | 2022-03-21 | 2024-11-05 | 勃林格殷格翰国际有限公司 | 用于治疗门脉高压的可溶性鸟苷酸环化酶活化剂 |
| TW202412753A (zh) | 2022-06-09 | 2024-04-01 | 德商拜耳廠股份有限公司 | 用於治療女性心臟衰竭合併保留射出分率的可溶性鳥苷酸環化酶活化劑 |
| US20240174653A1 (en) | 2022-11-04 | 2024-05-30 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclate activators for treating systemic sclerosis |
| WO2024123847A1 (en) | 2022-12-09 | 2024-06-13 | Boehringer Ingelheim International Gmbh | Solid forms of a sgc activator |
| WO2025036839A1 (en) | 2023-08-16 | 2025-02-20 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators for treating clinically significant portal hypertension and decompensated cirrhosis |
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| GB9824310D0 (en) * | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
| WO2002026712A2 (en) | 2000-09-29 | 2002-04-04 | Millennium Pharmaceuticals, Inc. | Quaternary amines and related inhibitors of factor xa |
| CA2428989A1 (en) | 2000-11-22 | 2002-05-30 | Visx Incorporated | Temperature actuated positioning device for non-linear optical elements |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| GB0212785D0 (en) * | 2002-05-31 | 2002-07-10 | Glaxo Group Ltd | Compounds |
| JP2006511583A (ja) * | 2002-12-20 | 2006-04-06 | ファルマシア・コーポレーション | マイトジェン活性化プロテインキナーゼ−活性化プロテインキナーゼ−２を阻害するための非環式ピラゾール化合物 |
| WO2007009607A1 (en) | 2005-07-18 | 2007-01-25 | Bayer Healthcare Ag | Novel use of activators and stimulators of soluble guanylate cyclase for the prevention or treatment of renal disorders |
| WO2008021339A2 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Pyrrolidine and related derivatives useful as pr modulators |
| MX2009011387A (es) * | 2007-05-12 | 2009-11-09 | Bayer Schering Pharma Ag | Estimulantes de la gcs, activadores de la gcs y combinaciones para el tratamiento de trastornos urologicos. |
| CA2698332C (en) | 2007-09-06 | 2012-08-21 | Merck Sharp & Dohme Corp. | Pyrazole derivatives as soluble guanylate cyclase activators |
| WO2009043495A1 (en) * | 2007-10-05 | 2009-04-09 | Sanofi-Aventis Deutschland Gmbh | Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid n-phenylamides in the treatment of pain |
| WO2009068652A1 (en) | 2007-11-30 | 2009-06-04 | Smithkline Beecham Corporation | 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines as soluble guanylate cyclase activators |
| UY31507A1 (es) * | 2007-12-03 | 2009-07-17 | Derivados de piridina activadores de guanilato ciclasa soluble | |
| CA2720343A1 (en) | 2008-04-04 | 2009-10-08 | Takeda Pharmaceutical Company Limited | Heterocyclic derivative and use thereof |
| WO2010015653A1 (en) * | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Pyrimidine derivatives as activators of soluble guanylate cyclase |
| WO2010015652A2 (en) * | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Thiazole compounds as activators of soluble guanylate cyclase |
| CA2743864A1 (en) | 2008-11-25 | 2010-06-10 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| WO2010081647A2 (en) * | 2009-01-17 | 2010-07-22 | Bayer Schering Pharma Aktiengesellschaft | Sgc stimulators of sgc activators in combination with pde5 inhbitors for the treatment of erectile dysfunction |
| KR20110133034A (ko) | 2009-02-26 | 2011-12-09 | 머크 샤프 앤드 돔 코포레이션 | 가용성 구아닐레이트 시클라제 활성화제 |
| WO2011095553A1 (en) | 2010-02-05 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft | Sgc stimulators or sgc activators in combination with pde5 inhbitors for the treatment of erectile dysfunction |
| BR112012019666A2 (pt) * | 2010-02-05 | 2017-06-20 | Bayer Ip Gmbh | estimuladores da sgc ou ativadores da sgc individualmente e em combinação com inibidores da pde5 para o tratamento de fibrose cística |
| JP5883852B2 (ja) * | 2010-05-26 | 2016-03-15 | アドヴェリオ・ファーマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 全身性強皮症（ＳＳｃ）を処置するためのｓＧＣ刺激剤、ｓＧＣアクチベーター単独およびＰＤＥ５阻害剤との組み合わせ剤の使用 |
| WO2011161099A1 (de) | 2010-06-25 | 2011-12-29 | Bayer Pharma Aktiengesellschaft | Verwendung von stimulatoren und aktivatoren der löslichen guanylatzyklase zur behandlung von sichelzellanämie und konservierung von blutersatzstoffen |
| US8895583B2 (en) | 2010-10-28 | 2014-11-25 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| US8569339B2 (en) | 2011-03-10 | 2013-10-29 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators |
| EP2766360B1 (en) | 2011-08-12 | 2017-07-12 | Boehringer Ingelheim International GmbH | Soluble guanylate cyclase activators |
| EP2594270A3 (en) | 2011-11-18 | 2013-07-31 | BIP Patents | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) |
| SG11201500861QA (en) * | 2012-09-07 | 2015-04-29 | Boehringer Ingelheim Int | Alkoxy pyrazoles as soluble guanylate cyclase activators |
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