[go: up one dir, main page]

CL2010000281A1 - Formulacion oral en forma de tableta de 9-[(2,2-dimetil-propilamino)-metil]-minociclina; metodo de preparacion; formulacion inyectable del mismo; utiles en el tratamiento de una infeccion. - Google Patents

Formulacion oral en forma de tableta de 9-[(2,2-dimetil-propilamino)-metil]-minociclina; metodo de preparacion; formulacion inyectable del mismo; utiles en el tratamiento de una infeccion.

Info

Publication number
CL2010000281A1
CL2010000281A1 CL2010000281A CL2010000281A CL2010000281A1 CL 2010000281 A1 CL2010000281 A1 CL 2010000281A1 CL 2010000281 A CL2010000281 A CL 2010000281A CL 2010000281 A CL2010000281 A CL 2010000281A CL 2010000281 A1 CL2010000281 A1 CL 2010000281A1
Authority
CL
Chile
Prior art keywords
formulation
infection
dimethyl
useful
preparation
Prior art date
Application number
CL2010000281A
Other languages
English (en)
Inventor
Johnston Sean
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41114256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2010000281(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Publication of CL2010000281A1 publication Critical patent/CL2010000281A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

FORMULACIÓN ORAL EN FORMA DE TABLETA DE 9-[(2,2-DIMETIL-PROPILAMINO)-METIL]-MINOCICLINA; MÉTODO DE PREPARACIÓN; FORMULACIÓN INYECTABLE DEL MISMO; ÚTILES EN EL TRATAMIENTO DE UNA INFECCIÓN.
CL2010000281A 2008-03-28 2010-03-29 Formulacion oral en forma de tableta de 9-[(2,2-dimetil-propilamino)-metil]-minociclina; metodo de preparacion; formulacion inyectable del mismo; utiles en el tratamiento de una infeccion. CL2010000281A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4039808P 2008-03-28 2008-03-28
PCT/US2009/001973 WO2009120389A1 (en) 2008-03-28 2009-03-30 Oral and injectable formulations of tetracycline compounds
US12/414,615 US9314475B2 (en) 2008-03-28 2009-03-30 Oral and injectable formulations of tetracycline compounds

Publications (1)

Publication Number Publication Date
CL2010000281A1 true CL2010000281A1 (es) 2012-03-30

Family

ID=41114256

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2010000281A CL2010000281A1 (es) 2008-03-28 2010-03-29 Formulacion oral en forma de tableta de 9-[(2,2-dimetil-propilamino)-metil]-minociclina; metodo de preparacion; formulacion inyectable del mismo; utiles en el tratamiento de una infeccion.

Country Status (31)

Country Link
US (2) US9314475B2 (es)
EP (3) EP2271348B1 (es)
JP (7) JP2011515473A (es)
KR (3) KR101835574B1 (es)
CN (1) CN102046177B (es)
AU (1) AU2009229174A1 (es)
BR (2) BRPI0909211B8 (es)
CA (2) CA2719751C (es)
CL (1) CL2010000281A1 (es)
CO (1) CO6300935A2 (es)
CY (2) CY1120240T1 (es)
DK (2) DK3348258T3 (es)
EC (1) ECSP10010576A (es)
ES (2) ES2836448T3 (es)
HK (1) HK1257928A1 (es)
HR (2) HRP20180836T1 (es)
HU (2) HUE052201T2 (es)
IL (1) IL208440A0 (es)
LT (2) LT2271348T (es)
MA (1) MA32275B1 (es)
MX (1) MX2010010585A (es)
NO (1) NO2271348T3 (es)
NZ (1) NZ588428A (es)
PL (2) PL3348258T3 (es)
PT (2) PT2271348T (es)
RU (1) RU2010144130A (es)
SI (2) SI2271348T1 (es)
TR (1) TR201806893T4 (es)
UA (2) UA109627C2 (es)
WO (1) WO2009120389A1 (es)
ZA (1) ZA201007013B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010009693A (es) 2008-03-05 2010-12-20 Paratek Pharm Innc Compuestos de monociclina y metodos de uso de la misma.
TWI680117B (zh) 2008-05-19 2019-12-21 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
EP2568987B1 (en) 2010-05-12 2016-11-16 Rempex Pharmaceuticals, Inc. Tetracycline compositions
TW201806604A (zh) * 2016-05-02 2018-03-01 派瑞泰製藥有限公司 ９－胺甲基米諾四環素化合物及其治療尿路感染（ｕｔｉ）之使用方法
US10166912B2 (en) 2016-08-19 2019-01-01 Sl Corporation Automotive LED driving apparatus
CA3042514A1 (en) 2016-11-01 2018-05-11 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
US12161655B2 (en) * 2018-09-04 2024-12-10 Paratek Pharmaceuticals, Inc. Methods of treating mycobacterial infections using tetracycline compounds
PT117254B (pt) 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2699054A (en) * 1953-10-09 1955-01-11 Lloyd H Conover Tetracycline
US2712517A (en) * 1954-03-03 1955-07-05 Bristol Lab Inc Production of tetracycline and substituted tetracyclines
US3019173A (en) * 1956-06-04 1962-01-30 American Cyanamid Co Method for preparing tetracycline
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US3005023A (en) * 1957-04-05 1961-10-17 American Cyanamid Co Production of tetracycline
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US2886595A (en) * 1958-09-30 1959-05-12 Bristol Lab Inc Tetracycline recovery
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3019260A (en) * 1959-05-13 1962-01-30 American Cyanamid Co Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
FR1430859A (es) * 1960-05-23 1966-05-25
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3301899A (en) * 1963-11-27 1967-01-31 Bristol Myers Co Purification of tetracycline
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (es) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds
DE122006000058I1 (de) 1991-10-04 2007-01-18 Wyeth Corp 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US6465431B1 (en) * 1999-11-17 2002-10-15 Boston Life Sciences, Inc. Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
EP1023065A1 (en) 1997-08-29 2000-08-02 Dsm N.V. Granules free of excipients
KR100252699B1 (ko) * 1998-03-17 2000-12-01 강재헌 치주염 치료용 미노사이클린 조성물
PT1137410E (pt) 1998-11-18 2007-01-31 Collagenex Pharm Inc Novos derivados da tetraciclina 4-dedimetilamina
US6448323B1 (en) 1999-07-09 2002-09-10 Bpsi Holdings, Inc. Film coatings and film coating compositions based on polyvinyl alcohol
AU2228901A (en) * 1999-12-28 2001-07-09 Chugai Seiyaku Kabushiki Kaisha Stable antibody compositions and injection preparations
ES2271070T3 (es) * 2000-07-07 2007-04-16 Trustees Of Tufts College Compuestos de minociclina 9-sustituidos.
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1368305B1 (en) 2001-03-13 2008-08-13 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
US7045507B2 (en) * 2001-03-14 2006-05-16 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
EP2311440A1 (en) 2001-04-05 2011-04-20 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2332549A1 (en) * 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Novel tetracyclines and their use in medicine
EP2311451A1 (en) * 2002-03-08 2011-04-20 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
CN1390550A (zh) * 2002-07-25 2003-01-15 于航 盐酸米诺环素冻干粉针剂及其制备方法
EP2277504A1 (en) * 2002-10-24 2011-01-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
JP4686189B2 (ja) * 2002-10-24 2011-05-18 パラテック ファーマシューティカルズ インコーポレイテッド Ｒｎａを調節するための置換テトラサイクリン化合物の使用方法
US20040121003A1 (en) 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy
JP4711947B2 (ja) * 2003-02-03 2011-06-29 ネオファーム、インコーポレイティッド 安定な濾過滅菌性リポソームに被包化されたタキサン及び他の抗腫瘍剤
WO2004078111A2 (en) * 2003-03-06 2004-09-16 Ranbaxy Laboratories Limited Extended release minocycline compositions and processes for their preparation
WO2004091513A2 (en) * 2003-04-10 2004-10-28 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP2319828A3 (en) * 2003-07-09 2011-07-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2004259661B2 (en) * 2003-07-09 2011-11-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
GB2414668B (en) * 2004-06-03 2009-07-29 Dexcel Ltd Tetracycline modified release delivery system
CA2602089C (en) * 2005-03-14 2013-04-30 Wyeth Tigecycline compositions and methods of preparation
EP1991236A2 (en) * 2006-01-24 2008-11-19 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
US20090246276A1 (en) * 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
MX2010009693A (es) * 2008-03-05 2010-12-20 Paratek Pharm Innc Compuestos de monociclina y metodos de uso de la misma.

Also Published As

Publication number Publication date
UA109627C2 (uk) 2015-09-25
CN102046177B (zh) 2012-12-19
CA2719751C (en) 2018-01-02
PT2271348T (pt) 2018-04-16
JP2016145260A (ja) 2016-08-12
BRPI0909211B8 (pt) 2021-05-25
ES2836448T3 (es) 2021-06-25
JP6577645B2 (ja) 2019-09-18
MA32275B1 (fr) 2011-05-02
EP2271348A1 (en) 2011-01-12
CY1123382T1 (el) 2021-12-31
US20160279151A1 (en) 2016-09-29
IL208440A0 (en) 2010-12-30
HK1257928A1 (zh) 2019-11-01
PT3348258T (pt) 2020-11-25
PL2271348T3 (pl) 2018-08-31
EP3348258A1 (en) 2018-07-18
DK3348258T3 (da) 2020-12-07
CY1120240T1 (el) 2019-07-10
HRP20180836T1 (hr) 2018-07-27
MX2010010585A (es) 2010-11-09
NZ588428A (en) 2012-08-31
CN102046177A (zh) 2011-05-04
JP2014221820A (ja) 2014-11-27
CA2984301C (en) 2020-10-27
BRPI0909211B1 (pt) 2020-08-25
EP2271348A4 (en) 2011-05-25
JP2018203778A (ja) 2018-12-27
KR20110008057A (ko) 2011-01-25
SI3348258T1 (sl) 2020-12-31
JP2021167355A (ja) 2021-10-21
JP2023144043A (ja) 2023-10-06
US9314475B2 (en) 2016-04-19
KR20160105532A (ko) 2016-09-06
PL3348258T3 (pl) 2021-03-08
NO2271348T3 (es) 2018-08-25
HUE052201T2 (hu) 2021-04-28
EP3789030A1 (en) 2021-03-10
EP2271348B1 (en) 2018-03-28
KR101893740B1 (ko) 2018-08-30
UA122762C2 (uk) 2021-01-06
BRPI0909211A2 (pt) 2016-11-29
LT2271348T (lt) 2018-06-25
BR122020011180B8 (pt) 2021-07-27
CO6300935A2 (es) 2011-07-21
JP2019196408A (ja) 2019-11-14
JP5940119B2 (ja) 2016-06-29
KR20180026799A (ko) 2018-03-13
HUE038257T2 (hu) 2018-10-29
BR122020011180B1 (pt) 2021-03-23
SI2271348T1 (en) 2018-08-31
ECSP10010576A (es) 2010-12-30
RU2010144130A (ru) 2012-05-10
DK2271348T3 (en) 2018-06-14
US20100056638A1 (en) 2010-03-04
JP6412521B2 (ja) 2018-10-24
WO2009120389A1 (en) 2009-10-01
CA2719751A1 (en) 2009-10-01
HRP20201883T1 (hr) 2021-01-22
WO2009120389A8 (en) 2009-12-30
JP2011515473A (ja) 2011-05-19
EP3348258B1 (en) 2020-09-09
ES2674708T3 (es) 2018-07-03
AU2009229174A1 (en) 2009-10-01
CA2984301A1 (en) 2009-10-01
TR201806893T4 (tr) 2018-06-21
KR101746228B1 (ko) 2017-06-12
ZA201007013B (en) 2013-11-27
KR101835574B1 (ko) 2018-03-08
LT3348258T (lt) 2020-12-10

Similar Documents

Publication Publication Date Title
CL2010000281A1 (es) Formulacion oral en forma de tableta de 9-[(2,2-dimetil-propilamino)-metil]-minociclina; metodo de preparacion; formulacion inyectable del mismo; utiles en el tratamiento de una infeccion.
CL2008000418A1 (es) Uso de un antagonista de la il-23 para el tratamiento de una infeccion fungica.
CL2016002589A1 (es) Uso del compuesto genz-112638 (eliglustat), inhibidor de glucosilceramida sintasa, en el tratamiento de la enfermedad de gaucher y enfermedad de fabry (divisional de solicitud 201201348).
CL2008001855A1 (es) Compuestos ciclicos condensados derivados del boro; composicion farmaceutica; y uso en el tratamiento y/o prevencion de una enfermedad infecciosa.
RS53124B (en) USE OF BETANECOL FOR THE TREATMENT OF XEROSOMOMY
CL2012001080A1 (es) Dispersión sólida de rifaximina y un portador farmacéuticamente aceptable; composición farmacéutica; uso en el tratarmiento y/o prevención de una infecciíon microbiana que comprende la administración de la dipersión sólida.
CL2008002540A1 (es) Compuestos derivados aza-indol-2,3-sustituidos; composicion farmaceutica; y uso ene l tratamiento de una infeccion viral.
CL2010000188A1 (es) Metodo para el tratamiento de una infeccion en un sujeto que comprende la administracion de 9-[(2,2-dimetil-propilamino)-metil]-minociclina o de una sal de la misma; composicion farmaceutica que comprende dicho compuesto; y su uso.
EA201170465A1 (ru) Способы лечения прогрессирующего множественного склероза
CL2008001157A1 (es) Compuestos derivados de quinolina-carboxamida, antagonistas de p2y12; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; composicion de una combinacion de dichos compuestos; y uso del compuesto en el tratamiento de trastornos cardiovasculares, tromboembolismo, infarto agudo al miocardio.
CL2013000018A1 (es) Compuestos derivados de indolizina , su procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento del cancer, entre otros.
CR20110596A (es) Composiciones sublinguales de dexmedetomidina y métodos de uso de ellas
DOP2012000312A (es) Triazolopiridinas sustituidas
CY1114190T1 (el) Νεα μορφη χορηγησης της ρασεκαδοτριλης
CL2008001373A1 (es) Compuestos derivados de fenilamino-benceno sustituidos; metodo de preparacion; composicion farmaceutica; kit farmceuticos; y uso de dichos compuestos en el tratamiento del cancer.
PE20140255A1 (es) Tableta dispersable en forma oral
CL2015002755A1 (es) Composiciones antibióticas de ceftolozano.
CO6491060A2 (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
CL2012003340A1 (es) Composicion farmaceutica de administracion oral de bendamustina y su uso en el tratamiento oral de una condicion medica seleccionada de leucemia linfocitica cronica, cancer de mama, entre otras.
CL2008003537A1 (es) Compuestos derivados de 2-amino-pirimidina, antagonistas de receptores h4; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de una enfermedad alergica, inmunologica o inflamatoria o dolor.
MX2011011109A (es) Formulaciones orales de bendamustina.
DOP2011000093A (es) Inhibidores de la integrasa del vih
DOP2009000285A (es) (oxazolidinon-5-il-metil)-2-tiofen-carboxamidas sustituidas y su uso en el campo de la coagulacion sanguinea.
UY33993A (es) Análogo macrocíclico de la sangliferina y su método de producción
GEP201606595B (en) (r) -nifuratel, its use for the treatment of infections and synthesis of (r) and (s) –nifuratel