CH622286A5 - - Google Patents

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Info

Publication number: CH622286A5
Authority: CH; Switzerland
Prior art keywords: group; hcl; thrombin; substrate; arginine
Prior art date: 1975-06-23

Application number

CH822475A

Other languages

German (de)

English (en)

Inventor

Lars Gundro Svendsen

Original Assignee

Pentapharm Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-06-23

Filing date

1975-06-23

Publication date

1981-03-31

1975-06-23 Application filed by Pentapharm Ag filed Critical Pentapharm Ag

1975-06-23 Priority to CH822475A priority Critical patent/CH622286A5/de

1976-06-11 Priority to IL49774A priority patent/IL49774A/xx

1976-06-14 Priority to IT24281/76A priority patent/IT1070002B/it

1976-06-16 Priority to AU14952/76A priority patent/AU511716B2/en

1976-06-18 Priority to US05/697,550 priority patent/US4070245A/en

1976-06-21 Priority to CA255,304A priority patent/CA1079167A/fr

1976-06-21 Priority to SU762373901A priority patent/SU673165A3/ru

1976-06-22 Priority to SE7607173A priority patent/SE430059B/xx

1976-06-22 Priority to AT453876A priority patent/AT349154B/de

1976-06-22 Priority to NO762163A priority patent/NO147213C/no

1976-06-22 Priority to FR7618995A priority patent/FR2315695A1/fr

1976-06-22 Priority to GB25832/76A priority patent/GB1553272A/en

1976-06-22 Priority to DK278576A priority patent/DK149333C/da

1976-06-22 Priority to DE2661080A priority patent/DE2661080C2/de

1976-06-22 Priority to DE19762627925 priority patent/DE2627925A1/de

1976-06-22 Priority to BE168177A priority patent/BE843245A/fr

1976-06-22 Priority to LU75212A priority patent/LU75212A1/xx

1976-06-22 Priority to NLAANVRAGE7606768,A priority patent/NL183038C/xx

1976-06-23 Priority to JP51074273A priority patent/JPS523494A/ja

1977-01-21 Priority to SU772440347A priority patent/SU1099839A3/ru

1981-03-31 Publication of CH622286A5 publication Critical patent/CH622286A5/de

Links

239000000758 substrate Substances 0.000 claims description 80
229940088598 enzyme Drugs 0.000 claims description 40
102000004190 Enzymes Human genes 0.000 claims description 39
108090000790 Enzymes Proteins 0.000 claims description 39
229960004072 thrombin Drugs 0.000 claims description 37
108090000190 Thrombin Proteins 0.000 claims description 36
-1 aromatic hydrocarbon radical Chemical class 0.000 claims description 26
210000002381 plasma Anatomy 0.000 claims description 26
238000000034 method Methods 0.000 claims description 23
108090000765 processed proteins & peptides Proteins 0.000 claims description 15
238000003776 cleavage reaction Methods 0.000 claims description 13
230000007017 scission Effects 0.000 claims description 13
238000006243 chemical reaction Methods 0.000 claims description 11
125000000217 alkyl group Chemical group 0.000 claims description 8
125000004432 carbon atom Chemical group C* 0.000 claims description 8
230000002345 thrombinlike Effects 0.000 claims description 8
239000004019 antithrombin Substances 0.000 claims description 7
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
108010085662 ecarin Proteins 0.000 claims description 7
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 6
108010094028 Prothrombin Proteins 0.000 claims description 6
102100027378 Prothrombin Human genes 0.000 claims description 6
125000002252 acyl group Chemical group 0.000 claims description 6
125000003277 amino group Chemical group 0.000 claims description 6
210000001124 body fluid Anatomy 0.000 claims description 6
239000010839 body fluid Substances 0.000 claims description 6
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
229940039716 prothrombin Drugs 0.000 claims description 6
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 5
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 5
239000004475 Arginine Substances 0.000 claims description 4
239000004472 Lysine Substances 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
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238000005859 coupling reaction Methods 0.000 claims 1
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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Chemical & Material Sciences (AREA)
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Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

CH822475A 1975-06-23 1975-06-23 CH622286A5 (fr)

Priority Applications (20)

Application Number	Priority Date	Filing Date	Title
CH822475A CH622286A5 (fr)	1975-06-23	1975-06-23
IL49774A IL49774A (en)	1975-06-23	1976-06-11	Substrate for the quantitative determination of enzymes
IT24281/76A IT1070002B (it)	1975-06-23	1976-06-14	Substrato cromogeno o fluorescente impiegabile come reagente per la determinazione quantitativa di enzimi proteolitici del gruppo e.c. 3.4.4.
AU14952/76A AU511716B2 (en)	1975-06-23	1976-06-16	Substrate for quantitative determination of proteolytic enzymes ofthe classe. C. 3. 4. 4
US05/697,550 US4070245A (en)	1975-06-23	1976-06-18	Substrate for the quantitative determination of proteolytic enzymes
CA255,304A CA1079167A (fr)	1975-06-23	1976-06-21	Substrat pour l'analyse quantitative des enzymes
SU762373901A SU673165A3 (ru)	1975-06-23	1976-06-21	Способ получени пептидов
SE7607173A SE430059B (sv)	1975-06-23	1976-06-22	Tripeptidderivat till anvendning som substrat for kvantitativ bestemning av proteolytiska enzymer samt anvendning av nemnda tripeptidderivat
AT453876A AT349154B (de)	1975-06-23	1976-06-22	Verfahren zur bestimmung von proteolytischen enzymen der gruppe e.c. 3.4.4.
NO762163A NO147213C (no)	1975-06-23	1976-06-22	Tripeptider for anvendelse som kromogene h.h.v. fluorescerende substrater ved enzymatiske bestemmelser
FR7618995A FR2315695A1 (fr)	1975-06-23	1976-06-22	Substrat chromogene ou fluorescent
GB25832/76A GB1553272A (en)	1975-06-23	1976-06-22	Substrate for the quantitative determination of enzymes
DK278576A DK149333C (da)	1975-06-23	1976-06-22	Tripeptidderivater samt salte deraf med mineralsyrer eller organiske syrer til anvendelse som substrater til kvantitativ bestemmelse af thrombin og thrombinlignende enzymer, ecarinthrombin, plasmin og plasminlignende enzymer samt proenzymer, proenzymaktivatorer og enzyminhibitorer herfor i legemsvaeskerfra mennesker og pattedyr samt i dyriske celleekstrakter
DE2661080A DE2661080C2 (fr)	1975-06-23	1976-06-22
DE19762627925 DE2627925A1 (de)	1975-06-23	1976-06-22	Chromogenes bzw. fluoreszierendes substrat
BE168177A BE843245A (fr)	1975-06-23	1976-06-22	Substrat chromogene ou fluorescent
LU75212A LU75212A1 (fr)	1975-06-23	1976-06-22
NLAANVRAGE7606768,A NL183038C (nl)	1975-06-23	1976-06-22	Werkwijze voor het bereiden van een substraat voor de kwantitatieve bepaling van proteolytische enzymen uit de groep e.c.3.4.21. en werkwijze voor het kwantitatief bepalen van dergelijke enzymen.
JP51074273A JPS523494A (en)	1975-06-23	1976-06-23	Reagents and method of proteolytic enzyme determination
SU772440347A SU1099839A3 (ru)	1975-06-23	1977-01-21	Способ определени тромбина, плазмина, трипсина и тромбиноподобных ферментов в биологических жидкост х

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH822475A CH622286A5 (fr)	1975-06-23	1975-06-23

Publications (1)

Publication Number	Publication Date
CH622286A5 true CH622286A5 (fr)	1981-03-31

Family

ID=4337046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH822475A CH622286A5 (fr)	1975-06-23	1975-06-23

Country Status (18)

Country	Link
US (1)	US4070245A (fr)
JP (1)	JPS523494A (fr)
AT (1)	AT349154B (fr)
AU (1)	AU511716B2 (fr)
BE (1)	BE843245A (fr)
CA (1)	CA1079167A (fr)
CH (1)	CH622286A5 (fr)
DE (2)	DE2661080C2 (fr)
DK (1)	DK149333C (fr)
FR (1)	FR2315695A1 (fr)
GB (1)	GB1553272A (fr)
IL (1)	IL49774A (fr)
IT (1)	IT1070002B (fr)
LU (1)	LU75212A1 (fr)
NL (1)	NL183038C (fr)
NO (1)	NO147213C (fr)
SE (1)	SE430059B (fr)
SU (2)	SU673165A3 (fr)

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SE407571B (sv) *	1975-07-11	1979-04-02	Kabi Ab	Nya kromogena enzymsubstrat for serinproteaser
US4169015A (en) *	1975-07-11	1979-09-25	Ab Kabi	Novel chromogenic thrombin substrates
US4191808A (en) *	1975-10-30	1980-03-04	Ajinomoto Co., Inc.	Method of measuring dipeptidyl-amino-peptidase activity
US4176009A (en) *	1976-01-24	1979-11-27	Ajinomoto Co., Inc.	Method of measuring collagenase activity
CH634662A5 (de) *	1976-05-28	1983-02-15	Pentapharm Ag	Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
US4167449A (en) *	1976-07-29	1979-09-11	American Hospital Supply Corporation	Composition and method for determining transferase and protease activity
SE437153B (sv) *	1976-12-01	1985-02-11	Kabi Ab	Specifika kromogena enzymsubstrat for serinproteaser
US4191809A (en) *	1977-02-26	1980-03-04	Ajinomoto Co., Inc.	Method of measuring enzymatic activity using novel peptide derivatives
CA1087075A (fr) *	1977-08-05	1980-10-07	Robert J. Gargiulo	Produit et methode de dosage de l'activite de la transferase et de la protease
DE2757992A1 (de) *	1977-12-24	1979-06-28	Boehringer Mannheim Gmbh	Verfahren zur prothrombin-bestimmung
SE7801373L (sv) *	1978-02-07	1979-08-08	Kabi Ab	Lett spjelkbara substrat for kvantifiering av proteaser
DE2812943C3 (de) *	1978-03-23	1981-05-14	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4275153A (en) *	1978-08-03	1981-06-23	American Hospital Supply Corporation	Analytical fluorogenic substrates for proteolytic enzymes
US4336186A (en) *	1978-08-03	1982-06-22	Gargiulo Robert J	Analytical fluorogenic substrates for proteolytic enzymes
US4216142A (en) *	1978-12-18	1980-08-05	Abbott Laboratories	Chromogenic substrates for the proteolytic enzymes
US4217269A (en) *	1979-03-23	1980-08-12	Abbott Laboratories	Dipeptide chromogenic substrates
US4219497A (en) *	1979-04-06	1980-08-26	Abbott Laboratories	Chromogenic substrates
EP0018002B1 (fr) *	1979-04-24	1983-02-09	Marcel Jozefonvicz	Procédé pour la détermination de protéases et d'anti-protéases
US4327178A (en) *	1979-05-01	1982-04-27	University Of Miami	Urinary kallikrein assay: specific substrates and assay method
US4221706A (en) *	1979-06-14	1980-09-09	Abbott Laboratories	Chromogenic substrates
US4244865A (en) *	1979-12-03	1981-01-13	Abbott Laboratories	α hydroxy tripeptide substrates
CA1161432A (fr) *	1980-02-12	1984-01-31	Lars G. Svendsen	Derives de tripeptides et application pour le dosage des enzymes
DE3108322A1 (de)	1980-03-18	1981-12-24	Immuno Aktiengesellschaft für chemisch-medizinische Produkte, 1220 Wien	Chromogenes enzymsubstrat
WO1982000641A1 (fr) *	1980-08-25	1982-03-04	Ab Kabivitrum	Substrats de peptides pour la determination de l'activite de proteases
JPH0258920B2 (fr) *	1980-10-09	1990-12-11	Boehringer Mannheim Gmbh
US4563305A (en) *	1981-01-07	1986-01-07	University Of Miami	Radiolabelled substrates for assaying mammalian enzymes
DE3113350A1 (de) *	1981-04-02	1982-10-21	Boehringer Mannheim Gmbh, 6800 Mannheim	Reagens zur optischen bestimmung des blutgerinnungsverhaltens
US4434096A (en)	1981-06-30	1984-02-28	E. I. Du Pont De Nemours And Company	Substrates for the quantitative determination of proteolytic enzymes
JPS5856695A (ja) *	1981-09-28	1983-04-04	Nitto Boseki Co Ltd	新規なトロンビン測定用基質
JPS5863399A (ja) *	1981-10-14	1983-04-15	Nitto Boseki Co Ltd	新規なプラスミン測定用基質
US4448715A (en) *	1981-11-02	1984-05-15	University Of Miami	Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
DE3211254A1 (de) *	1982-03-26	1983-09-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
DE3244030A1 (de) *	1982-11-27	1984-05-30	Behringwerke Ag, 3550 Marburg	Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
JPS6061557A (ja) *	1983-09-14	1985-04-09	Nitto Boseki Co Ltd	アルギニル−ｐ−ニトロアニリド化合物の製造方法
DE3413311A1 (de) *	1984-04-09	1985-10-17	Behringwerke Ag, 3550 Marburg	Reagenz zur bestimmung der thromboplastinzeit
US4897444A (en) *	1985-05-31	1990-01-30	The Research Foundation Of The State University Of New York	Immobilized fluorogenic substrates for enzymes; and processes for their preparation
JP2516365B2 (ja) *	1987-05-09	1996-07-24	サンスタ−株式会社	歯周疾患検査薬
DE3710937A1 (de) *	1987-04-01	1988-10-13	Boehringer Mannheim Gmbh	Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate
JPH01112157A (ja) *	1987-07-10	1989-04-28	Yamanouchi Pharmaceut Co Ltd	組織プラスミノーゲンアクチベーター活性の測定法，測定具及び測定用キット
FR2689640B1 (fr) *	1992-04-06	1997-08-08	Bio Merieux	Procede pour la determination d'une activite proteine c et/ou proteine s dans un echantillon plasmatique.
DK0638127T3 (da) *	1992-04-27	2000-12-18	Avocet Medical Inc	Testartikel og fremgangsmåde til at udføre blodkoagulationsanalyser
NL1006429C2 (nl) *	1997-06-27	1998-12-29	Univ Maastricht	Werkwijze voor het bepalen van het heparinegehalte.
DE19904674A1 (de)	1999-02-04	2000-08-31	Haemosys Gmbh	Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren
EP1367135A1 (fr) *	2002-05-29	2003-12-03	Pentapharm AG	Procédé amélioré pour l'évaluation de formation de thrombin dans plasma sanguine
EP1802649B1 (fr) *	2004-10-12	2011-01-19	F. Hoffmann-La Roche AG	Synthese de peptides en phase solide

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IL42124A (en) *	1972-05-02	1977-02-28	Kabi Ab	Substrate for the determination of proteolytic enzymes
SE380257B (sv) *	1972-05-02	1975-11-03	Bofors Ab	Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

1975
- 1975-06-23 CH CH822475A patent/CH622286A5/de not_active IP Right Cessation
1976
- 1976-06-11 IL IL49774A patent/IL49774A/xx unknown
- 1976-06-14 IT IT24281/76A patent/IT1070002B/it active
- 1976-06-16 AU AU14952/76A patent/AU511716B2/en not_active Expired
- 1976-06-18 US US05/697,550 patent/US4070245A/en not_active Expired - Lifetime
- 1976-06-21 SU SU762373901A patent/SU673165A3/ru active
- 1976-06-21 CA CA255,304A patent/CA1079167A/fr not_active Expired
- 1976-06-22 NO NO762163A patent/NO147213C/no unknown
- 1976-06-22 DK DK278576A patent/DK149333C/da not_active IP Right Cessation
- 1976-06-22 AT AT453876A patent/AT349154B/de not_active IP Right Cessation
- 1976-06-22 NL NLAANVRAGE7606768,A patent/NL183038C/xx not_active IP Right Cessation
- 1976-06-22 BE BE168177A patent/BE843245A/fr not_active IP Right Cessation
- 1976-06-22 DE DE2661080A patent/DE2661080C2/de not_active Expired - Lifetime
- 1976-06-22 FR FR7618995A patent/FR2315695A1/fr active Granted
- 1976-06-22 DE DE19762627925 patent/DE2627925A1/de active Granted
- 1976-06-22 GB GB25832/76A patent/GB1553272A/en not_active Expired
- 1976-06-22 SE SE7607173A patent/SE430059B/xx not_active IP Right Cessation
- 1976-06-22 LU LU75212A patent/LU75212A1/xx unknown
- 1976-06-23 JP JP51074273A patent/JPS523494A/ja active Granted
1977
- 1977-01-21 SU SU772440347A patent/SU1099839A3/ru active

Also Published As

Publication number	Publication date
AU1495276A (en)	1977-12-22
SU1099839A3 (ru)	1984-06-23
SE7607173L (sv)	1976-12-24
DE2627925C2 (fr)	1987-07-16
SE430059B (sv)	1983-10-17
AT349154B (de)	1979-03-26
IL49774A0 (en)	1976-08-31
DE2627925A1 (de)	1976-12-30
CA1079167A (fr)	1980-06-10
FR2315695B1 (fr)	1980-07-25
JPS5622519B2 (fr)	1981-05-26
IL49774A (en)	1979-11-30
BE843245A (fr)	1976-10-18
DE2661080C2 (fr)	1990-03-22
NL183038C (nl)	1988-07-01
DK278576A (da)	1976-12-24
NL7606768A (nl)	1976-12-27
DK149333B (da)	1986-05-05
DK149333C (da)	1986-10-20
LU75212A1 (fr)	1977-02-17
NO762163L (fr)	1976-12-27
NL183038B (nl)	1988-02-01
FR2315695A1 (fr)	1977-01-21
AU511716B2 (en)	1980-09-04
IT1070002B (it)	1985-03-25
ATA453876A (de)	1978-08-15
JPS523494A (en)	1977-01-11
NO147213B (no)	1982-11-15
GB1553272A (en)	1979-09-26
SU673165A3 (ru)	1979-07-05
US4070245A (en)	1978-01-24
NO147213C (no)	1983-02-23

Publication	Publication Date	Title
CH622286A5 (fr)	1981-03-31
DE2527932C2 (de)	1983-04-21	Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
DE2724211C2 (de)	1987-03-05	Tripeptidderivate und deren Verwendung
WO1981002294A1 (fr)	1981-08-20	Derives tripeptidiques et leur utilisation pour la determination d'enzymes
CH619983A5 (fr)	1980-10-31
EP1157029B1 (fr)	2005-12-28	Derives d'oligopeptides pour la mesure electrochimique de l'activite de proteases
DE2322116A1 (de)	1973-11-22	Substrat mit hoher empfindlichkeit fuer proteolytische enzyme vom typ der peptidpeptidohydrolasen
EP0203509B1 (fr)	1991-04-03	Procédé pour la détermination quantitative de la protéine-C et une préparation activatrice pour sa réalisation
CH622285A5 (fr)	1981-03-31
DE2322115B2 (de)	1980-01-10	Tripeptide und deren Verwendung zur Bestimmung von Peptid-Peptidohydrolasen
EP0025190A2 (fr)	1981-03-18	Composés chromogènes et leur utilisation en tant que substrats enzymatiques
EP0456152A2 (fr)	1991-11-13	Peptide-amides, leur procédé de préparation et les agents contenant ces peptides inhibiteurs de la coagulation de fibrine/thrombine
EP0019589B1 (fr)	1983-11-09	Dérivés de tripeptides et leur utilisation dans un procédé pour déterminer les enzymes
DE2734427C3 (de)	1980-04-17	Verfahren zur Gewinnung von thrombinartigen Enzymen aus Schlangengiften
DE2629195C3 (de)	1983-11-17	Tripeptide und deren Verwendung zur Bestimmung von Thrombin
WO1994027958A1 (fr)	1994-12-08	4-amidinophenylsulfonamides pour le traitement de maladies thromboemboliques
DE102005003145B4 (de)	2006-10-19	Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests
EP0128118A2 (fr)	1984-12-12	Dérivés de peptides et leur utilisation comme substrats pour la détermination quantitative d'enzymes
EP0190299A1 (fr)	1986-08-13	NOUVEAUX PEPTIDES DE p-PHENYLENEDIAMINE ET REACTIFS LES CONTENANT POUR DETERMINER DES PROTEINASES DU SYSTEME DE COAGULATION DU SANG
CH609154A5 (en)	1979-02-15	Method for the quantitative determination of proteolytic enzymes in body fluids from humans and mammals
CH641761A5 (en)	1984-03-15	Tripeptide derivatives for the determination of plasminogen activators and trypsin
DE3202289A1 (de)	1982-09-16	Verfahren zur bestimmung der c(pfeil abwaerts)1(pfeil abwaerts)-esterase-inhibitor-aktivitaet von c(pfeil abwaerts)1(pfeil abwaerts)-esterase-inhibitor-haeltigen proben
DE3685724T2 (de)	1993-01-28	Synthetisches peptid-substrat fuer die bestimmung von trypsin und alpha-1-antitrypsin.
DD279485A5 (de)	1990-06-06	Verfahren zur herstellung chromogener verbindungen und ihre verwendung
DE69017903T2 (de)	1995-11-02	Peptidsubstrate zur identifikation von faktor xa.

Legal Events

Date	Code	Title	Description
1995-08-31	PL	Patent ceased
2024-10-31	PL	Patent ceased